dinoprost and droxicam

dinoprost has been researched along with droxicam* in 1 studies

Other Studies

1 other study(ies) available for dinoprost and droxicam

Article	Year
Effects of droxicam on in vivo prostaglandin synthesis and ex vivo platelet aggregation. Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:4 Droxicam, similar to piroxicam, inhibits in vivo renal synthesis of PGF2 alpha. This study was performed in rats; droxicam and piroxicam were administered orally at doses of 0.5, 1.2 and 8 mg/kg. Inhibitory activity of the two compounds was similar (40-60%) but showed no dose-effect relationship. Maximum inhibition was obtained with the 1 mg/kg dosage. In dogs droxicam has shown a clear inhibitory effect on arachidonic acid induced ex vivo platelet aggregation. Droxicam was administered orally at a dose of 2 mg/kg. Maximum inhibition (-40%) was achieved 24 hr post-administration and the effect was sustained up to 72 hr (-23%). Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Dinoprost; Dogs; Kidney; Male; Piroxicam; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins F; Pyridines; Rats; Rats, Inbred Strains	1987

Article

Year

Effects of droxicam on in vivo prostaglandin synthesis and ex vivo platelet aggregation.

Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:4

Droxicam, similar to piroxicam, inhibits in vivo renal synthesis of PGF2 alpha. This study was performed in rats; droxicam and piroxicam were administered orally at doses of 0.5, 1.2 and 8 mg/kg. Inhibitory activity of the two compounds was similar (40-60%) but showed no dose-effect relationship. Maximum inhibition was obtained with the 1 mg/kg dosage. In dogs droxicam has shown a clear inhibitory effect on arachidonic acid induced ex vivo platelet aggregation. Droxicam was administered orally at a dose of 2 mg/kg. Maximum inhibition (-40%) was achieved 24 hr post-administration and the effect was sustained up to 72 hr (-23%).

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Dinoprost; Dogs; Kidney; Male; Piroxicam; Platelet Aggregation; Prostaglandin Antagonists; Prostaglandins F; Pyridines; Rats; Rats, Inbred Strains

1987