dinoprost and abacavir

The aim of the study was to investigate the in vivo effect of abacavir (ABC) on platelet oxidative stress.. We performed a randomized pilot study including 39 HIV-1-infected patients, 17 on zidovudine/lamivudine (ZDV/3TC) and 22 on tenofovir/emtricitabine (TDF/FTC). Ten patients on ZDV/3TC and eight patients on TDF/FTC were randomly allocated to switching the nucleoside backbone to ABC/3TC. At baseline and after 6 months, platelet oxidative stress was assessed by platelet NADPH oxidase 2 (NOX2)-derived peptide (sNOX2-dp), a marker of NOX2 activation, and platelet prostaglandin F

Topics: Adolescent; Adult; Anti-HIV Agents; Blood Platelets; CD40 Ligand; Dideoxynucleosides; Dinoprost; Female; HIV Infections; Humans; Male; Membrane Glycoproteins; Middle Aged; NADPH Oxidase 2; NADPH Oxidases; Pilot Projects; Platelet Activation; Young Adult