dinoprost and 4-hydroxybenzaldehyde

dinoprost has been researched along with 4-hydroxybenzaldehyde* in 1 studies

Other Studies

1 other study(ies) available for dinoprost and 4-hydroxybenzaldehyde

Article	Year
Structural insight into the stereoselective production of PGF2α by Old Yellow Enzyme from Trypanosoma cruzi. Journal of biochemistry, 2011, Volume: 150, Issue:5 Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2α) by TcOYE. Topics: Benzaldehydes; Catalytic Domain; Crystallography, X-Ray; Dinoprost; Flavin Mononucleotide; NADPH Dehydrogenase; Protozoan Proteins; Trypanosoma cruzi	2011

Article

Year

Structural insight into the stereoselective production of PGF2α by Old Yellow Enzyme from Trypanosoma cruzi.

Journal of biochemistry, 2011, Volume: 150, Issue:5

Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2α) by TcOYE.

Topics: Benzaldehydes; Catalytic Domain; Crystallography, X-Ray; Dinoprost; Flavin Mononucleotide; NADPH Dehydrogenase; Protozoan Proteins; Trypanosoma cruzi

2011