diminazene and pentamidine

diminazene has been researched along with pentamidine in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (19.72)	18.7374
1990's	16 (22.54)	18.2507
2000's	12 (16.90)	29.6817
2010's	24 (33.80)	24.3611
2020's	5 (7.04)	2.80

Authors

Authors	Studies
Clercq, ED; Dann, O	1
Frydman, B; Gasteier, J; Heby, O; Jiang, Y; Marton, LJ; Roberts, SC; Ullman, B	1
Brun, R; de Koning, HP; Gould, M; Kaiser, M; Koomen, GJ; Rodenko, B; van der Burg, AM; Wanner, MJ	1
Changtam, C; de Koning, HP; Gould, MK; Ibrahim, H; Sajid, MS; Suksamrarn, A	1
Maciejewska, D; Zołek, T	1
Avery, VM; Davis, RA; Demirkiran, O; Fechner, GA; Quinn, RJ; Suraweera, L; Sykes, ML	1
Brun, R; Fotie, J; Gershkovich, P; He, S; Liu, Q; Patrick, DA; Premalatha, K; Reid, CS; Tidwell, RR; Wang, MZ; Wasan, KM; Wenzler, T; Werbovetz, KA	1
Avery, VM; Camp, D; Davis, RA; Quinn, RJ; Sykes, M	1
Capes, A; Collie, IT; Fairlamb, AH; Frearson, JA; Gilbert, IH; Hallyburton, I; McCarroll, AJ; Patterson, S; Stevens, MF; Wyatt, PG; Wyllie, S	1
Alkhaldi, AA; Chana, A; Dardonville, C; de Koning, HP; Eze, AA; Flores Pérez, EJ; Healy, A; Herrero García, V; Kaiser, M; Ríos Martínez, C; Taladriz, A	1
Huang, TL; Mayence, A; Vanden Eynde, JJ	1
Alkhaldi, AA; Dardonville, C; De Koning, HP	1
Alkorta, I; Dardonville, C; de Koning, HP; Ebiloma, GU; Nué Martínez, JJ; Ríos Martínez, CH	1
Balogun, EO; Bruggeman, V; Dardonville, C; de Koning, HP; Donachie, A; Ebiloma, GU; Fueyo González, FJ; Harada, S; Inaoka, DK; Izquierdo García, C; Kita, K; Sánchez Villamañán, JM; Shiba, T	1
Ayuga, TD; Balogun, EO; Dardonville, C; de Koning, HP; Donachie, A; Ebiloma, GU; Gil, LA; Harada, S; Herraiz, T; Inaoka, DK; Kaiser, M; Kita, K; Shiba, T	1
Caljon, G; Campagnaro, GD; de Koning, HP; Hulpia, F; Maes, L; Scortichini, M; Van Calenbergh, S; Van Hecke, K	1
Alfayez, IA; Bouton, J; Caljon, G; Campagnaro, GD; de Koning, HP; Hulpia, F; Mabille, D; Maes, L; Van Calenbergh, S	1
Abdel-Megeed, AM; Avery, VM; Baell, JB; Brown, RW; Hyland, CJT; Jones, AJ; Kaiser, M; Keller, PA; Sykes, ML	1
Choongo, K; Ishikawa, Y; Kikuchi, T; Munsimbwe, L; Murata, T; Shirakura, I; Suganuma, K	1
Aldfer, MM; Arai, N; Bernal-Fraile, T; Chevillard, R; Cisneros, D; Cueto-Díaz, EJ; Dardonville, C; de Koning, HP; Ebiloma, GU; Elati, HAA; Kojima, C; López-Sastre, R; Matsushiro, S; Medina-Gil, T; Otani, M; Shiba, T; Ungogo, MA	1
Bacchi, CJ; Chunosoff, L; Hutner, SH; Moreira, R; Nathan, HC; Soto, KV	1
Raether, W; Seidenath, H	1
Junqueira, RG; Mares-Guia, M; Silva, E	1
Libby, PR; Porter, CW	1
Jennings, FW	1
Englund, PT; Shapiro, TA	1
Dann, O; Estler, CJ; Steinmann, U	1
Brun, R; Kunz, C	1
Jefferies, D; Jenni, L	1
Karvonen, E	1
Rathaur, S; Walter, RD; Wittich, RM	1
Balber, AE; Frommel, TO	1
Gupta, S; Shukla, OP; Walter, RD	1
Bitonti, AJ; Dumont, JA; McCann, PP	1
Karvonen, E; Kauppinen, L; Partanen, T; Pösö, H	1
Dukes, P	1
Cobb, CC; Farwell, GE; LeGrand, EK	1
Fang, W; Sandholm, M	1
Bodley, AL; McGarry, MW; Shapiro, TA	1
Milord, F; Pépin, J	1
Alvarez Bujidos, ML; Balaña Fouce, R; Cubria, JC; Ordoñez, D; Reguera, R	1
Alvarez-Bujidos, ML; Balaña Fouce, R; Cubría, JC; Negro, A; Ordóñez, D; Ortiz, AI	1
Brown, DG; Jenkins, TC; Lane, AN; Neidle, S	1
Baltz, T; Barrett, MP; Denise, H; Giroud, C; Zhang, ZQ	1
Fang, W; Koivunen, AL; Maisi, P; Sandholm, M	1
Scott, AG; Tait, A; Turner, CM	1
Coetzer, TH; Jones, R; Lonsdale-Eccles, JD; Morty, RE; Nickel, P; Pike, RN; Troeberg, L	1
Gray, JS; Pudney, M	1
Reinert, KE	1
Asiri, SA; Ogbunude, PO	1
Barrett, MP; Brun, R; Burchmore, RJ; de Koning, HP; Enyaru, JC; Geiser, F; Kaminsky, R; Mäser, P; Matovu, E; Seebeck, T; Stewart, ML; Wallace, LJ	1
Atsriku, C; Grant, MH; Skellern, GG; Watson, DG	1
Rudenko, G; Sheader, K; te Vruchte, D	1
Coombs, GH; Goyeneche, D; Jean-Moreno, V; Rojas, R; Walker, J	1
Anene, BM; Barrett, MP; Brock, JM; De Koning, HP; Ezeokonkwo, RC; Mmesirionye, TI; Tettey, JN	1
Agama, KK; Antony, S; Fisher, RJ; Marchand, C; Pommier, Y; Stephen, AG; Thibaut, L	1
Akpa, PO; Anene, BM; Eze, CA; Ezeokonkwo, RC	1
Brown, DE; Collyer, CA; Dooley, DM; Elmore, BO; Guss, JM; Hilmer, KM; McGrath, AP; Shepard, EM	1
Avery, VM; Sykes, ML	1
Chen, X; Dürrnagel, S; Li, M; MacDonald, JF; Orser, BA; Qiu, L; Xiong, ZG	1
Arafa, RK; Boykin, DW; Brun, R; Gillingwater, K; Ismail, MA; Kumar, A; Stephens, CE; Tidwell, RR	1
Hwang, SJ; Maede, Y; Murakami, M; Nakamura, K; Ohta, H; Sasaki, N; Takiguchi, M; Wickramasekara Rajapakshage, BK; Yamasaki, M	1
Nagem, RA; Pereira, MT; Perilo, CS; Santoro, MM	1
Al-Salabi, MI; Barrett, MP; de Koning, HP; El-Sabbagh, N; Eze, AA; Kazibwe, AJ; Mäser, P; Matovu, E; Munday, JC; Teka, IA; Ward, CP	1
Allamanda, P; Angeles, JM; Hakimi, H; Inoue, N; Kawazu, S; Suganuma, K; Zhou, M	1
Alkhaldi, AA; Alzahrani, KJ; De Koning, HP; Eze, AA; Krezdorn, JA; McDonald, F; Munday, JC; Rojas López, KE; Settimo, L; Still, J; Tagoe, DN	1
Zsila, F	1
Inoue, N; Molefe, NI; Suganuma, K	1
Herzig, V; King, GF; Kotze, AC; Nixon, SA; Saez, NJ	1
Freza, S; Samsonov, SA; Zsila, F	1
Auma, JE; Chemuliti, JK; Gitonga, PK; Kurgat, RK; Mdachi, RE; Murilla, GA; Ndung'u, K; Ngae, GN; Thuita, JK; Thungu, DK	1

Reviews

2 review(s) available for diminazene and pentamidine

Article	Year
Some non-conventional biomolecular targets for diamidines. A short survey. Bioorganic & medicinal chemistry, 2014, Apr-01, Volume: 22, Issue:7 Topics: Amidines; Animals; Diabetes Mellitus, Type 2; DNA; Enzymes; Humans; Hypertension; Ion Channels; Myotonic Dystrophy; Neoplasms; Neurodegenerative Diseases; Proteins; RNA; Thrombosis	2014
The treatment of human African trypanosomiasis. Advances in parasitology, 1994, Volume: 33 Topics: Animals; Diminazene; Eflornithine; Humans; Melarsoprol; Nifurtimox; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosomiasis, African	1994

Other Studies

69 other study(ies) available for diminazene and pentamidine

Article	Year
Diaryl amidine derivatives as oncornaviral DNA polymerase inhibitors. Journal of medicinal chemistry, 1980, Volume: 23, Issue:7 Topics: Amidines; Animals; Antineoplastic Agents; Kinetics; Leukemia, Experimental; Mice; Moloney murine leukemia virus; Retroviridae; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Tilorone	1980
Leishmania donovani polyamine biosynthetic enzyme overproducers as tools to investigate the mode of action of cytotoxic polyamine analogs. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2 Topics: Adenosylmethionine Decarboxylase; Animals; Antiprotozoal Agents; Butylamines; Deoxyadenosines; Drug Resistance; Eflornithine; Leishmania donovani; Ornithine Decarboxylase; Parasitic Sensitivity Tests; Signal Transduction; Spermidine Synthase; Transfection	2007
2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:11 Topics: Adenosine; Animals; Antimalarials; Dose-Response Relationship, Drug; Molecular Structure; Plasmodium falciparum; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2007
Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Antimalarials; Cell Line; Curcumin; Diarylheptanoids; Humans; Inhibitory Concentration 50; Leishmania; Molecular Structure; Trypanocidal Agents; Trypanosoma	2010
Theoretical models of pentamidine analogs activity based on their DNA minor groove complexes. European journal of medicinal chemistry, 2010, Volume: 45, Issue:5 Topics: Binding Sites; DNA; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Nucleic Acid Denaturation; Pentamidine; Spectrophotometry, Ultraviolet; Stereoisomerism; Temperature	2010
7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata. Bioorganic & medicinal chemistry letters, 2010, Jul-15, Volume: 20, Issue:14 Topics: Cell Line, Tumor; Humans; Lactones; Pyrones; Trypanocidal Agents	2010
Synthesis and antitrypanosomal evaluation of derivatives of N-benzyl-1,2-dihydroquinolin-6-ols: Effect of core substitutions and salt formation. Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1 Topics: Animals; Cyclization; Mice; Quinolines; Salts; Structure-Activity Relationship; Trypanocidal Agents	2011
Convolutamines I and J, antitrypanosomal alkaloids from the bryozoan Amathia tortusa. Bioorganic & medicinal chemistry, 2011, Nov-15, Volume: 19, Issue:22 Topics: Animals; Bryozoa; HEK293 Cells; Humans; Indole Alkaloids; Nuclear Magnetic Resonance, Biomolecular; Plasmodium falciparum; Trypanocidal Agents; Trypanosoma brucei brucei	2011
Quinol derivatives as potential trypanocidal agents. Bioorganic & medicinal chemistry, 2012, Feb-15, Volume: 20, Issue:4 Topics: Benzamidines; Cell Line; Drug Delivery Systems; Humans; Hydroquinones; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Triazines; Trypanocidal Agents; Trypanosoma brucei brucei	2012
Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes. Journal of medicinal chemistry, 2012, Mar-22, Volume: 55, Issue:6 Topics: Carrier Proteins; Cell Line; Drug Resistance; Humans; Models, Molecular; Nucleoside Transport Proteins; Organophosphorus Compounds; Pentamidine; Quantitative Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma brucei rhodesiense	2012
SAR Studies of Diphenyl Cationic Trypanocides: Superior Activity of Phosphonium over Ammonium Salts. ACS medicinal chemistry letters, 2015, Feb-12, Volume: 6, Issue:2 Topics:	2015
Lowering the pKa of a bisimidazoline lead with halogen atoms results in improved activity and selectivity against Trypanosoma brucei in vitro. European journal of medicinal chemistry, 2015, Aug-28, Volume: 101 Topics: Cell Survival; Dose-Response Relationship, Drug; Halogens; HEK293 Cells; Humans; Hydrogen-Ion Concentration; Imidazolines; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi	2015
Conjugates of 2,4-Dihydroxybenzoate and Salicylhydroxamate and Lipocations Display Potent Antiparasite Effects by Efficiently Targeting the Trypanosoma brucei and Trypanosoma congolense Mitochondrion. Journal of medicinal chemistry, 2017, 02-23, Volume: 60, Issue:4 Topics: Cell Line; Drug Discovery; Humans; Hydroxybenzoates; Membrane Potential, Mitochondrial; Mitochondria; Salicylamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African	2017
Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. European journal of medicinal chemistry, 2018, Apr-25, Volume: 150 Topics: Benzaldehydes; Cations; Dose-Response Relationship, Drug; Mitochondrial Proteins; Molecular Structure; Oxidoreductases; Parabens; Parasitic Sensitivity Tests; Plant Proteins; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma congolense	2018
Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity. European journal of medicinal chemistry, 2019, Feb-15, Volume: 164 Topics: Animals; Biological Transport; Kinetoplastida; Mice; Nucleoside Transport Proteins; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei; Tubercidin	2019
C6-O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents. European journal of medicinal chemistry, 2020, Feb-15, Volume: 188 Topics: Alkylation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Humans; Inosine; Molecular Structure; Nucleosides; Parasitic Sensitivity Tests; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2020
Investigation of thiazolyl-benzothiophenamides as potential agents for African sleeping sickness. RSC medicinal chemistry, 2020, Dec-17, Volume: 11, Issue:12 Topics:	2020
Benzophenone Glucosides and B-Type Proanthocyanidin Dimers from Zambian Journal of natural products, 2022, 01-28, Volume: 85, Issue:1 Topics: Benzophenones; Cassia; Crystallography, X-Ray; Dimerization; Glucosides; Molecular Structure; Proanthocyanidins; Proton Magnetic Resonance Spectroscopy; Trypanocidal Agents; Trypanosoma	2022
Imidazoline- and Benzamidine-Based Trypanosome Alternative Oxidase Inhibitors: Synthesis and Structure-Activity Relationship Studies. ACS medicinal chemistry letters, 2022, Feb-10, Volume: 13, Issue:2 Topics:	2022
Curative effects of the antipiroplasms amicarbalide and imidocarb on Trypanosoma brucei infection in mice. The Journal of protozoology, 1979, Volume: 26, Issue:4 Topics: Amidines; Animals; Carbanilides; Chemical Phenomena; Chemistry; Diminazene; Female; Imidocarb; Male; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1979
Trypanocidal effect of diamidine 98/202 in experimental Trypanosoma rhodesiense infection of the stumptailed macaque (Macaca arctoides). Tropenmedizin und Parasitologie, 1976, Volume: 27, Issue:2 Topics: Amidines; Animals; Blood-Brain Barrier; Cerebrospinal Fluid; Diminazene; Drug Resistance, Microbial; Female; Haplorhini; Macaca; Male; Microbial Sensitivity Tests; Pentamidine; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African	1976
Competitive parabolic inhibition of bovine trypsin by bis-benzamidines. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1992, Volume: 25, Issue:9 Topics: Animals; Cattle; Diminazene; In Vitro Techniques; Kinetics; Organoplatinum Compounds; Pentamidine; Structure-Activity Relationship; Substrate Specificity; Trypsin; Trypsin Inhibitors	1992
Inhibition of enzymes of polyamine back-conversion by pentamidine and berenil. Biochemical pharmacology, 1992, Aug-18, Volume: 44, Issue:4 Topics: Acetyltransferases; Animals; Diminazene; Humans; Kinetics; Leukemia L1210; Melanoma; Mice; Oxidoreductases Acting on CH-NH Group Donors; Pentamidine; Polyamine Oxidase	1992
Chemotherapy of CNS-trypanosomiasis: the combined use of diminazene aceturate or pentamidine with DL-alpha-difluoromethylornithine (DFMO). Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1992, Volume: 43, Issue:2 Topics: Animals; Arsenicals; Central Nervous System Diseases; Diminazene; Drug Administration Schedule; Drug Therapy, Combination; Eflornithine; Female; Mice; Pentamidine; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1992
Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:3 Topics: Animals; Diminazene; DNA Topoisomerases, Type I; DNA, Circular; DNA, Kinetoplast; Ethidium; Molecular Structure; Pentamidine; Phenanthridines; Restriction Mapping; Trypanocidal Agents; Trypanosoma	1990
Plasma histamine levels in rats treated with trypanocidal diamidines. Pharmacology, 1988, Volume: 36, Issue:3 Topics: Amidines; Animals; Diminazene; Histamine; Histamine Release; Male; Pentamidine; Rats; Rats, Inbred Strains; Trypanocidal Agents	1988
In vitro drug sensitivity test for Trypanosoma brucei subgroup bloodstream trypomastigotes. Acta tropica, 1989, Volume: 46, Issue:5-6 Topics: Animals; Arsenicals; Diminazene; Hypoxanthine; Hypoxanthines; Leucine; Pentamidine; Phenanthridines; Suramin; Thymidine; Trypanocidal Agents; Trypanosoma brucei brucei	1989
The effect of trypanocidal drugs on the transmission of Trypanosoma brucei brucei by Glossina morsitans centralis. Acta tropica, 1987, Volume: 44, Issue:1 Topics: Animals; Diminazene; Pentamidine; Phenanthridines; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Tsetse Flies	1987
Inhibition of diamine oxidase of rat small intestine by pentamidine and berenil (diminazene aceturate). Biochemical pharmacology, 1987, Sep-01, Volume: 36, Issue:17 Topics: Amidines; Amine Oxidase (Copper-Containing); Animals; Diminazene; Intestine, Small; Pentamidine; Rats; Structure-Activity Relationship	1987
Ascaris suum and Onchocerca volvulus: S-adenosylmethionine decarboxylase. Experimental parasitology, 1988, Volume: 65, Issue:2 Topics: Adenosylmethionine Decarboxylase; Animals; Ascaris; Carboxy-Lyases; Chromatography, Gel; Diminazene; Enzyme Activation; Female; Magnesium; Male; Mitoguazone; Onchocerca; Pentamidine; Polyethylene Glycols; Putrescine	1988
Flow cytofluorimetric analysis of drug accumulation by multidrug-resistant Trypanosoma brucei brucei and T. b. rhodesiense. Molecular and biochemical parasitology, 1987, Volume: 26, Issue:1-2 Topics: Acriflavine; Animals; Benzimidazoles; Diminazene; Drug Resistance; Ethidium; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; Melarsoprol; Mice; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei	1987
Putrescine-activated S-adenosylmethionine decarboxylase from Acanthamoeba culbertsoni. Molecular and biochemical parasitology, 1987, Volume: 23, Issue:3 Topics: Adenosylmethionine Decarboxylase; Amoeba; Animals; Carboxy-Lyases; Cell-Free System; Diminazene; Enzyme Activation; Kinetics; Metals; Mitoguazone; Molecular Weight; Pentamidine; Putrescine	1987
Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone). The Biochemical journal, 1986, Aug-01, Volume: 237, Issue:3 Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Carboxy-Lyases; Diminazene; Male; Mitoguazone; Pentamidine; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine; Trypanocidal Agents; Trypanosoma brucei brucei	1986
Irreversible inhibition of putrescine-stimulated S-adenosyl-L-methionine decarboxylase by berenil and pentamidine. The Biochemical journal, 1985, Oct-01, Volume: 231, Issue:1 Topics: Adenosylmethionine Decarboxylase; Amidines; Animals; Carboxy-Lyases; Diminazene; Diphenylamine; Liver; Pentamidine; Pseudomonas aeruginosa; Putrescine; Rats; S-Adenosylmethionine; Saccharomyces cerevisiae	1985
Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma brucei. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1984, Volume: 78, Issue:6 Topics: Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Isoenzymes; Male; Melarsoprol; Mice; Pentamidine; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	1984
Clinical observations on Babesia gibsoni and Babesia canis infections in dogs. Journal of the American Veterinary Medical Association, 1982, Mar-01, Volume: 180, Issue:5 Topics: Animals; Babesiosis; Diminazene; Dog Diseases; Dogs; Erythrocytes; Female; Japan; Pentamidine	1982
Inhibition of the proteinase activity in mastitic milk. The Journal of dairy research, 1995, Volume: 62, Issue:1 Topics: Animals; Aprotinin; Cattle; Diminazene; Dithiothreitol; Endopeptidases; Female; Fibrinolysin; Mastitis, Bovine; Mercaptoethanol; Milk; Pentamidine; Protease Inhibitors; Urokinase-Type Plasminogen Activator	1995
Drug cytotoxicity assay for African trypanosomes and Leishmania species. The Journal of infectious diseases, 1995, Volume: 172, Issue:4 Topics: Acid Phosphatase; Amphotericin B; Animals; Camptothecin; Diminazene; Drug Evaluation, Preclinical; Leishmania donovani; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei	1995
Putrescine uptake inhibition by aromatic diamidines in Leishmania infantum promastigotes. Biochemical pharmacology, 1994, May-18, Volume: 47, Issue:10 Topics: Amidines; Animals; Diminazene; Indoles; Kinetics; Leishmania infantum; Pentamidine; Putrescine; Stilbamidines	1994
Aromatic diamidines are reversible inhibitors of porcine kidney diamine oxidase. Biochemical pharmacology, 1993, Mar-24, Volume: 45, Issue:6 Topics: Acquired Immunodeficiency Syndrome; Amine Oxidase (Copper-Containing); Animals; Benzamidines; Binding Sites; Diminazene; Kidney; Kinetics; Pentamidine; Stilbamidines; Swine	1993
NMR and molecular modeling studies of the interaction of berenil and pentamidine with d(CGCAAATTTGCG)2. European journal of biochemistry, 1993, May-01, Volume: 213, Issue:3 Topics: Base Sequence; Binding Sites; Crystallography; Diminazene; DNA; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Oligodeoxyribonucleotides; Pentamidine; Trypanocidal Agents	1993
A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity. Molecular and biochemical parasitology, 1995, Volume: 73, Issue:1-2 Topics: Adenosine; Animals; Arsenicals; Biological Transport, Active; Carrier Proteins; Diminazene; Drug Resistance; Kinetics; Pentamidine; Receptors, Purinergic P2; Trypanocidal Agents; Trypanosoma	1995
Inhibition of the protease activity in tracheobronchial aspirates of horses with chronic obstructive pulmonary disease. American journal of veterinary research, 1996, Volume: 57, Issue:5 Topics: Acetylcysteine; Animals; Cluster Analysis; Diminazene; Endopeptidases; Horse Diseases; Horses; Immunodiffusion; Lung Diseases, Obstructive; Pentamidine; Protease Inhibitors; Suction; Trachea	1996
Trypanosoma brucei: lack of cross-resistance to melarsoprol in vitro by cymelarsan-resistant parasites. Experimental parasitology, 1997, Volume: 86, Issue:3 Topics: Adenine; Adenosine; Animals; Arsenicals; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Female; Inosine; Melarsoprol; Mice; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei	1997
A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin. FEBS letters, 1998, Aug-21, Volume: 433, Issue:3 Topics: Animals; Diminazene; Pentamidine; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship; Suramin; Trypanocidal Agents; Trypanosoma	1998
Activity of atovaquone against Babesia microti in the Mongolian gerbil, Meriones unguiculatus. The Journal of parasitology, 1999, Volume: 85, Issue:4 Topics: Acute Disease; Animals; Antiprotozoal Agents; Atovaquone; Babesiosis; Chronic Disease; Clindamycin; Diminazene; Dose-Response Relationship, Drug; Drug Resistance; Drug Therapy, Combination; Gerbillinae; Humans; Imidocarb; Naphthoquinones; Pentamidine; Recurrence	1999
DNA multimode interaction with berenil and pentamidine; double helix stiffening, unbending and bending. Journal of biomolecular structure & dynamics, 1999, Volume: 17, Issue:2 Topics: Animals; Cattle; Diminazene; DNA; DNA, Complementary; Intercalating Agents; Kinetics; Ligands; Models, Theoretical; Nucleic Acid Conformation; Pentamidine; Temperature; Trypanocidal Agents	1999
In vitro effect of diamidines on intracellular polyamines of Acanthamoeba polyphaga. Drugs under experimental and clinical research, 2001, Volume: 27, Issue:4 Topics: Acanthamoeba; Animals; Antiprotozoal Agents; Benzamidines; Diminazene; Humans; Pentamidine; Polyamines; Pyridines; Robenidine	2001
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei. Eukaryotic cell, 2003, Volume: 2, Issue:5 Topics: Adenine; Adenosine; Animals; Arsenicals; Benzamidines; Cell Death; Cell Division; Diminazene; Drug Resistance; Female; Gene Silencing; Hypoxanthine; Inhibitory Concentration 50; Inosine; Melarsoprol; Mice; Mutation; Nucleoside Transport Proteins; Pentamidine; Stilbamidines; Trypanosoma brucei brucei	2003
The effect of inducing agents on the metabolism of trypanocidal diamidines by isolated rat hepatocytes. Chemico-biological interactions, 2003, Dec-15, Volume: 146, Issue:3 Topics: Animals; Chromatography, Liquid; Cytochrome P-450 Enzyme System; Diminazene; Enzyme Induction; Hepatocytes; Humans; In Vitro Techniques; Male; Methylcholanthrene; Nitriles; Pentamidine; Phenobarbital; Pyrethrins; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Trypanocidal Agents	2003
Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage. The Journal of biological chemistry, 2004, Apr-02, Volume: 279, Issue:14 Topics: Animals; Antiprotozoal Agents; Aphidicolin; Blood; Diminazene; DNA Damage; Enzyme Inhibitors; Gene Silencing; Genes, Reporter; Green Fluorescent Proteins; Luminescent Proteins; Membrane Glycoproteins; Pentamidine; Protozoan Proteins; RNA Polymerase I; S Phase; Suramin; Transcription, Genetic; Trypanocidal Agents; Trypanosoma brucei brucei; Up-Regulation; Variant Surface Glycoproteins, Trypanosoma	2004
Leishmania donovani: differential activities of classical topoisomerase inhibitors and antileishmanials against parasite and host cells at the level of DNA topoisomerase I and in cytotoxicity assays. Experimental parasitology, 2006, Volume: 112, Issue:1 Topics: Acid Phosphatase; Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Benzimidazoles; Berberine Alkaloids; Bisbenzimidazole; Camptothecin; Cell Line; Diminazene; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Leishmania donovani; Luciferases, Firefly; Luminescent Agents; Macrophages; Monocytes; Pentamidine; Quercetin; Topoisomerase I Inhibitors	2006
A diminazene-resistant strain of Trypanosoma brucei brucei isolated from a dog is cross-resistant to pentamidine in experimentally infected albino rats. Parasitology, 2006, Volume: 132, Issue:Pt 1 Topics: Animals; Diminazene; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Resistance; Female; Parasitic Sensitivity Tests; Pentamidine; Random Allocation; Rats; Recurrence; Time Factors; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African	2006
Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1. Nucleic acids research, 2007, Volume: 35, Issue:13 Topics: Antineoplastic Agents; Benzamidines; Diminazene; DNA; DNA, Single-Stranded; Drug Evaluation, Preclinical; Electrochemistry; Humans; Kinetics; Luminescent Measurements; Pentamidine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Thymidine	2007
Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs. Veterinary parasitology, 2008, Feb-14, Volume: 151, Issue:2-4 Topics: Animals; Blood Cell Count; Body Temperature; Diminazene; Dog Diseases; Dogs; Enzymes; Female; Hemoglobins; Male; Pentamidine; Time Factors; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis	2008
Structure and inhibition of human diamine oxidase. Biochemistry, 2009, Oct-20, Volume: 48, Issue:41 Topics: Amine Oxidase (Copper-Containing); Animals; Binding Sites; Calcium; Copper; Crystallography, X-Ray; Dimerization; Diminazene; Drosophila; Humans; Kinetics; Metallothionein; Models, Molecular; Pentamidine; Promoter Regions, Genetic; Protein Conformation; Substrate Specificity; X-Ray Diffraction	2009
Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427. The American journal of tropical medicine and hygiene, 2009, Volume: 81, Issue:4 Topics: Animals; Diminazene; Humans; Indicators and Reagents; Oxazines; Pentamidine; Sensitivity and Specificity; Sphingosine; Staining and Labeling; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Xanthenes	2009
Diarylamidines: high potency inhibitors of acid-sensing ion channels. Neuropharmacology, 2010, Volume: 58, Issue:7 Topics: Acid Sensing Ion Channels; Amidines; Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Diminazene; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Hippocampus; Indoles; Mice; Nerve Tissue Proteins; Neurons; Neurotransmitter Agents; Oocytes; Pentamidine; Sodium Channels; Stilbamidines; Xenopus laevis	2010
In vitro activity and preliminary toxicity of various diamidine compounds against Trypanosoma evansi. Veterinary parasitology, 2010, May-11, Volume: 169, Issue:3-4 Topics: Amidines; Animals; Arsenicals; Cells, Cultured; Diminazene; Drug Resistance; Female; Inhibitory Concentration 50; Mice; Pentamidine; Quinolinium Compounds; Rats; Suramin; Trypanocidal Agents; Trypanosoma; Trypanosomiasis	2010
Development and characterization of a strain of Babesia gibsoni resistant to diminazene aceturate in vitro. The Journal of veterinary medical science, 2010, Volume: 72, Issue:6 Topics: Animals; Antiprotozoal Agents; Babesia; Babesiosis; Cell Division; Clindamycin; Diminazene; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Doxycycline; Drug Resistance; Erythrocytes; Metronidazole; Pentamidine	2010
Structural binding evidence of the trypanocidal drugs berenil and pentacarinate active principles to a serine protease model. International journal of biological macromolecules, 2010, Volume: 46, Issue:5 Topics: Animals; Calorimetry; Cattle; Crystallography, X-Ray; Diminazene; Models, Molecular; Pentamidine; Thermodynamics; Trypanocidal Agents; Trypsin; Trypsin Inhibitors	2010
The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes. Molecular pharmacology, 2011, Volume: 80, Issue:1 Topics: Animals; Carrier Proteins; Diminazene; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei	2011
Establishment of ATP-based luciferase viability assay in 96-well plate for Trypanosoma congolense. The Journal of veterinary medical science, 2014, Volume: 76, Issue:11 Topics: Adenosine Triphosphate; Animals; Cell Division; Dimethyl Sulfoxide; Diminazene; High-Throughput Screening Assays; Inhibitory Concentration 50; Luciferases; Pentamidine; Species Specificity; Time Factors; Trypanosoma congolense; Trypanosomiasis, African	2014
Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein. Molecular microbiology, 2015, Volume: 96, Issue:4 Topics: Alleles; Diminazene; Drug Resistance, Multiple; Kinetics; Melarsoprol; Models, Molecular; Mutation; Nucleoside Transport Proteins; Parasitic Sensitivity Tests; Pentamidine; Polymorphism, Single Nucleotide; Protein Interaction Domains and Motifs; Trypanocidal Agents; Trypanosoma brucei brucei	2015
Glycosaminoglycans are potential pharmacological targets for classic DNA minor groove binder drugs berenil and pentamidine. Physical chemistry chemical physics : PCCP, 2015, Oct-14, Volume: 17, Issue:38 Topics: Antiprotozoal Agents; Chondroitin Sulfates; Circular Dichroism; Diminazene; DNA; Glycosaminoglycans; Pentamidine; Spectrophotometry, Ultraviolet	2015
An ATP-Based Luciferase Viability Assay for Animal African Trypanosomes Using a 96-Well Plate. Methods in molecular biology (Clifton, N.J.), 2017, Volume: 1601 Topics: Adenosine Triphosphate; Animals; Cell Survival; Diminazene; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Luciferases; Pentamidine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma congolense; Trypanosomiasis, African	2017
The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary parasitology, 2019, Volume: 270 Topics: Animals; Anthelmintics; Antiprotozoal Agents; Diminazene; Haemonchus; In Vitro Techniques; Inhibitory Concentration 50; Pentamidine	2019
In silico analysis of heparin and chondroitin sulfate binding mechanisms of the antiprotozoal drug berenil and pentamidine. Carbohydrate research, 2019, Aug-01, Volume: 482 Topics: Antiprotozoal Agents; Chondroitin Sulfates; Computer Simulation; Diminazene; Heparin; Hydrogen Bonding; Molecular Conformation; Molecular Dynamics Simulation; Pentamidine; Quantum Theory; Thermodynamics	2019
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model. PloS one, 2020, Volume: 15, Issue:11 Topics: Animals; Diminazene; Disease Models, Animal; Drug Resistance; Kenya; Male; Melarsoprol; Mice; Pentamidine; Suramin; Treatment Outcome; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosomiasis, African; Uganda; Virulence	2020