dimethadione has been researched along with trimethadione in 52 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (59.62) | 18.7374 |
| 1990's | 16 (30.77) | 18.2507 |
| 2000's | 2 (3.85) | 29.6817 |
| 2010's | 3 (5.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Chrysanthopoulos, PK; Dolezal, O; Mujumdar, P; Peat, TS; Poulsen, SA; Ren, B; Woods, LA | 1 |
| Göbel, W; Löscher, W | 1 |
| Buttar, HS; Dupuis, I; Midha, KK; Rowe, M | 1 |
| Boisse, NR; Okamoto, M; Rosenberg, HC | 1 |
| Hayakawa, T; Kamiya, N; Noda, A; Takayama, T | 1 |
| Anderson, RC | 1 |
| Hayakawa, T; Nakajima, S; Noda, A; Suzuki, T; Toda, Y | 1 |
| Aoki, I; Hayakawa, T; Horiguchi, Y; Noda, A; Toda, Y | 1 |
| Diwan, BA; Henneman, JR; Lubet, RA; Nims, RW; Rice, JM; Ward, JM | 1 |
| Misawa, S; Tanaka, E | 2 |
| Abei, M; Adachi, S; Fukao, K; Ishikawa, A; Iwasaki, Y; Osada, A; Takase, Y; Tanaka, E; Tsuji, K; Yamamoto, Y | 1 |
| Akita, H; Hamada, K; Iida, S; Kobayashi, S; Sakai, H; Tanaka, E; Uchida, E; Yasuhara, H | 1 |
| Ibuki, E; Kato, H; Noda, A; Okumura, I; Tamada, M; Watanabe, T | 1 |
| Hotta, S; Ibuki, E; Miyamoto, E; Noda, A; Nomoto, K; Okumura, I; Takeuchi, K; Watanabe, T | 1 |
| Greco, GS; Nagai, MK; Wells, PG | 1 |
| Fukao, K; Ishikawa, A; Iwasaki, Y; Misawa, S; Tanaka, E; Yamamoto, Y | 1 |
| Ishikawa, A; Misawa, S; Okamura, T; Ono, A; Tanaka, E | 2 |
| Ishikawa, A; Kuroiwa, Y; Misawa, S; Tanaka, E | 1 |
| Fukao, K; Ishikawa, A; Iwasaki, Y; Misawa, S; Tanaka, E; Tsuji, K | 1 |
| Nakanishi, Y; Noda, A; Yamamoto, K | 1 |
| Ishikawa, A; Kobayashi, S; Misawa, S; Okamura, T; Ono, A; Tanaka, E; Yasuhara, H | 1 |
| Ishikawa, A; Misawa, S; Okamura, T; Ono, A; Takada, A; Tanaka, E | 1 |
| Kurata, N; Kuroiwa, Y; Misawa, S; Tanaka, E | 1 |
| Kuroiwa, Y; Tanaka, E; Yoshida, T | 1 |
| Kuroiwa, Y; Misawa, S; Tanaka, E | 1 |
| Alderdice, MT; McMillan, JE | 1 |
| Kobayashi, S; Kuroiwa, Y; Oguchi, K; Tanaka, E; Yasuhara, H; Yoshida, T | 1 |
| Kuroiwa, Y; Misawa, S; Nakamura, T; Tanaka, E; Yoshida, T | 1 |
| Frankena, H; Zweens, J | 1 |
| Kinoshita, H; Kuroiwa, Y; Tanaka, E; Yoshida, T | 4 |
| Hagino, S; Kuroiwa, Y; Tanaka, E; Yoshida, T | 1 |
| Kinoshita, H; Kuroiwa, Y; Takabatake, E; Tanaka, E; Yamamoto, T | 1 |
| Abei, M; Ikegami, T; Ishikawa, A; Matsuzaki, Y; Osuga, T; Tanaka, E; Tanaka, N | 1 |
| Inagaki, M; Iwase, M; Kiuchi, Y; Kobayashi, S; Kurata, N; Nishimura, Y; Oguchi, K; Uchida, E; Yamazaki, Y; Yasuhara, H | 1 |
| Kobayashi, S; Kurata, N; Nishimura, Y; Uchida, E; Yasuhara, H | 1 |
| Ishikawa, A; Kobayashi, S; Kuroiwa, Y; Misawa, S; Tanaka, E; Yasuhara, H | 1 |
| Fukao, K; Horie, T; Ishikawa, A; Mikami, T; Momose, Y; Nakamura, T; Osada, A; Tanaka, E | 1 |
| Funae, Y; Tanaka, E | 1 |
| Coulter, DA; Gibbs, JW; Zhang, YF | 1 |
| Abei, M; Ishikawa, A; Kobayashi, S; Tanaka, E | 1 |
| Horie, T; Kitada, M; Ohmori, S; Sawa, Y; Tanaka, E; Taniguchi, T | 1 |
| Iwase, M; Kurata, N; Li, H; Nishimura, Y; Yasuhara, H | 1 |
| Azarbayjani, F; Danielsson, BR | 1 |
| PLUM, CM | 1 |
| Brown, NA; Ozolinš, TR; Weston, AD | 1 |
| Brown, NA; Ozolinš, TR; Perretta, A; Thomson, JJ; Weston, AD | 1 |
2 review(s) available for dimethadione and trimethadione
| Article | Year |
|---|---|
Trimethadione metabolism as a probe drug to estimate hepatic oxidizing capacity in rats.
Topics: Animals; Dimethadione; Liver; Oxidation-Reduction; Rats; Rats, Wistar; Trimethadione | 1993 |
Trimethadione as a probe drug to estimate hepatic oxidizing capacity in humans.
Topics: Administration, Oral; Animals; Clinical Trials as Topic; Dimethadione; Humans; Liver Diseases; Microsomes, Liver; Oxidants; Trimethadione | 1996 |
50 other study(ies) available for dimethadione and trimethadione
| Article | Year |
|---|---|
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Identification of a New Zinc Binding Chemotype by Fragment Screening.
Topics: Benzenesulfonamides; Carbonic Anhydrase II; Carbonic Anhydrase Inhibitors; Crystallography, X-Ray; Humans; Molecular Docking Simulation; Oxazolidinones; Structure-Activity Relationship; Sulfonamides; Zinc | 2017 |
Consecutive gas chromatographic determination of phenytoin, phenobarbital, primidone, phenylethylmalondiamide, carbamazepine, trimethadione, dimethadione, ethosuximide, and valproate from the same serum specimen.
Topics: Anticonvulsants; Carbamazepine; Chromatography, Gas; Dimethadione; Ethosuximide; Phenobarbital; Phenylethylmalonamide; Phenytoin; Primidone; Trimethadione; Valproic Acid | 1978 |
Metabolism and disposition of trimethadione in pregnant rats.
Topics: Abnormalities, Drug-Induced; Animals; Dimethadione; Drug Evaluation, Preclinical; Female; Fetus; Oxazoles; Pregnancy; Rats; Teratogens; Trimethadione | 1979 |
Evaluation of anticonvulsants in barbiturate withdrawal.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cats; Dimethadione; Female; Humans; Male; Pentobarbital; Phenobarbital; Phenytoin; Seizures; Substance Withdrawal Syndrome; Time Factors; Trimethadione | 1977 |
Pancreatolithiasis and pancreatic carcinoma. Evaluation of pancreatic excretion test with 5,5-dimethyl-2,4-oxazolidinedione.
Topics: Calculi; Cholecystokinin; Dimethadione; Duodenum; Humans; Oxazoles; Pancreatic Diseases; Pancreatic Neoplasms; Secretin; Trimethadione | 1977 |
Cardiac defects in children of mothers receiving anticonvulsant therapy during pregnancy.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Cleft Lip; Cleft Palate; Dimethadione; Drug Therapy, Combination; Epilepsy; Ethosuximide; Female; Heart Defects, Congenital; Humans; Infant, Newborn; Male; Mephobarbital; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Trimethadione | 1976 |
Pancreatic excretion of 5, 5-dimethyl-2, 4-oxazolidinedione in normal subjects.
Topics: Adult; Aged; Bicarbonates; Bilirubin; Cholecystokinin; Dimethadione; Duodenum; Female; Humans; Intestinal Secretions; Male; Middle Aged; Oxazoles; Pancreas; Secretin; Trimethadione | 1975 |
Pancreatic excretion of 5,5-dimethyl-2,4-oxazolidinedione in patients with chronic pancreatitis.
Topics: Adult; Cholecystokinin; Chronic Disease; Dimethadione; Duodenum; Female; Humans; Intestinal Secretions; Male; Middle Aged; Oxazoles; Pancreas; Pancreatitis; Secretin; Trimethadione | 1975 |
Effects of the oxazolidinedione anticonvulsants trimethadione and dimethadione and the barbiturate homolog 5,5-dimethylbarbituric acid on N-nitrosodiethylamine-initiated renal and hepatic carcinogenesis in the F344/NCr rat.
Topics: Animals; Barbiturates; Body Weight; Cocarcinogenesis; Cytochrome P-450 CYP2B1; Cytochrome P-450 Enzyme System; Diethylnitrosamine; Dimethadione; Enzyme Induction; Kidney Neoplasms; Liver Neoplasms, Experimental; Male; Organ Size; Oxidoreductases; Rats; Rats, Inbred F344; Trimethadione | 1992 |
Improved method for the determination of trimethadione and its demethylated metabolite, dimethadione, in human serum by gas chromatography.
Topics: Adult; Chromatography, Gas; Dimethadione; Half-Life; Humans; Male; Middle Aged; Reference Values; Reproducibility of Results; Trimethadione | 1992 |
Trimethadione tolerance test for one-point estimation of the severity of liver damage in cirrhotic patients.
Topics: Dimethadione; Female; Hepatic Encephalopathy; Humans; Indocyanine Green; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Trimethadione | 1991 |
The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates.
Topics: Adult; Antipyrine; Debrisoquin; Diltiazem; Dimethadione; Drug Interactions; Half-Life; Humans; Liver; Male; Mixed Function Oxygenases; Trimethadione | 1991 |
Pancreatic excretion of dimethadione and trimethadione by repeated oral administration of trimethadione in dogs.
Topics: Administration, Oral; Animals; Dimethadione; Dogs; Dose-Response Relationship, Drug; Pancreas; Pancreatic Fistula; Pancreatic Juice; Trimethadione | 1990 |
Effect of dimethadione derived from repeated oral administration of trimethadione on pancreatic secretion in dogs.
Topics: Administration, Oral; Animals; Bicarbonates; Dimethadione; Dogs; Hydrogen-Ion Concentration; Pancreas; Pancreatic Juice; Trimethadione | 1990 |
Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cleft Palate; Dealkylation; Dimethadione; Dose-Response Relationship, Drug; Female; Mice; Oxazoles; Phenytoin; Pregnancy; Trimethadione | 1989 |
The metabolism and excretion of trimethadione in patients with percutaneous transhepatic biliary drainage and renal dysfunction.
Topics: Adult; Aged; Bile; Biliary Tract Diseases; Dimethadione; Female; Half-Life; Humans; Kidney Diseases; Male; Middle Aged; Oxazoles; Trimethadione | 1989 |
Trimethadione metabolism in patients with normal liver and in patients with chronic liver disease.
Topics: Carcinoma, Hepatocellular; Chronic Disease; Dimethadione; Female; Humans; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Oxazoles; Trimethadione | 1987 |
Sex-related differences in hepatic drug-oxidizing capacity of streptozotocin-induced diabetic rats.
Topics: Animals; Antipyrine; Diabetes Mellitus, Experimental; Dimethadione; Female; Insulin; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxazoles; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sex Factors; Trimethadione | 1988 |
Simultaneous determination of serum trimethadione and its metabolite by gas chromatography.
Topics: Animals; Biotransformation; Chromatography, Gas; Dimethadione; Humans; Oxazoles; Rats; Species Specificity; Trimethadione | 1987 |
Age-related changes in trimethadione oxidizing capacity.
Topics: Adult; Aged; Aging; Alanine Transaminase; Aspartate Aminotransferases; Dimethadione; Half-Life; Humans; Kinetics; Male; Middle Aged; Oxazoles; Oxidation-Reduction; Serum Albumin; Trimethadione | 1987 |
[Measurement of microsomal function in hepatectomized rat].
Topics: Animals; Carbon Tetrachloride Poisoning; Dimethadione; Hepatectomy; Liver; Male; Microsomes, Liver; Oxazoles; Rats; Rats, Inbred Strains; Trimethadione | 1987 |
Comparative pharmacokinetic study of trimethadione and dimethadione for lysis of pancreatic stones.
Topics: Administration, Oral; Animals; Dimethadione; Dogs; Metabolic Clearance Rate; Oxazoles; Pancreatic Diseases; Trimethadione | 1986 |
Trimethadione tolerance test for evaluation of functional reserve of the liver in patients with liver cirrhosis and esophageal varices.
Topics: Adult; Dimethadione; Esophageal and Gastric Varices; Female; Humans; Kinetics; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Oxazoles; Trimethadione | 1986 |
Hepatic trimethadione-oxidizing capacity remains normal in patients with extrahepatic cholelithiasis.
Topics: Bilirubin; Cholelithiasis; Dimethadione; Humans; Liver; Middle Aged; Oxazoles; Trimethadione | 1986 |
Influence of short-term water deprivation on kinetics of trimethadione and its metabolite in rats.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cytochrome P-450 Enzyme System; Dimethadione; Food Deprivation; Kinetics; Male; Microsomes, Liver; Oxazoles; Rats; Rats, Inbred Strains; Trimethadione; Water Deprivation | 1986 |
Dose-independent pharmacokinetics of trimethadione and its metabolite in rats.
Topics: Animals; Chromatography, Gas; Dimethadione; Kinetics; Liver; Male; Oxazoles; Rats; Rats, Inbred Strains; Time Factors; Trimethadione | 1985 |
Effects of cimetidine and diethylaminoethyl 2,2-diphenylvalerate HCL (SKF 525-A) on trimethadione metabolism in the rat.
Topics: Animals; Cimetidine; Cytochrome P-450 Enzyme System; Dimethadione; Kinetics; Liver; Male; Oxazoles; Proadifen; Rats; Rats, Inbred Strains; Trimethadione | 1985 |
Comparison of the effects of trimethadione and its primary metabolite dimethadione on neuromuscular function and the effects of altered pH on the actions of dimethadione.
Topics: Animals; Dimethadione; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Motor Endplate; Neuromuscular Junction; Oxazoles; Rana pipiens; Synaptic Transmission; Time Factors; Trimethadione | 1982 |
A method for estimation of hepatic drug-metabolizing capacity: determination of concentration of trimethadione and its metabolite in human serum.
Topics: Adult; Animals; Antipyrine; Dimethadione; Half-Life; Humans; Kinetics; Liver; Male; Middle Aged; Oxazoles; Rats; Trimethadione | 1984 |
Effects of allyl alcohol and bromobenzene on trimethadione metabolism in the rat.
Topics: 1-Propanol; Animals; Bromobenzenes; Chemical and Drug Induced Liver Injury; Dimethadione; Kinetics; Liver; Male; Microsomes, Liver; Oxazoles; Oxidation-Reduction; Propanols; Proteins; Rats; Rats, Inbred Strains; Trimethadione | 1984 |
Simultaneous determination of dimethadione and trimethadione by infrared-spectrometry: application for mean intracellular pH measurement.
Topics: Dimethadione; Humans; Hydrogen-Ion Concentration; Magnesium Sulfate; Oxazoles; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Sulfates; Trimethadione | 1984 |
Relationship between trimethadione metabolism and hepatic drug-oxidizing enzyme activities in different animal species.
Topics: Animals; Antipyrine; Cricetinae; Cytochrome P-450 Enzyme System; Dimethadione; Kinetics; Liver; Male; Mice; Oxazoles; Rabbits; Rats; Species Specificity; Trimethadione | 1983 |
Simultaneous determination of trimethadione and its metabolite in rat and human serum by high-performance liquid chromatography.
Topics: Administration, Oral; Adult; Animals; Chromatography, Gas; Chromatography, High Pressure Liquid; Dimethadione; Half-Life; Humans; Kinetics; Male; Middle Aged; Oxazoles; Rats; Rats, Inbred Strains; Species Specificity; Trimethadione | 1984 |
Determination of trimethadione and its metabolite by gas chromatography with flame-thermionic detection and its application to pharmacokinetic studies of the drug in carbon tetrachloride-treated rats.
Topics: Animals; Carbon Tetrachloride; Chromatography, Gas; Dimethadione; Half-Life; Kinetics; Male; Oxazoles; Rats; Rats, Inbred Strains; Trimethadione | 1983 |
Trimethadione as a model drug for the evaluation of hepatic drug-metabolizing capacity in normal and D-galactosamine intoxicated rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cytochromes; Dimethadione; Galactosamine; Kinetics; Liver; Male; Oxazoles; Rats; Rats, Inbred Strains; Trimethadione | 1982 |
Pharmacokinetic studies of trimethadione and its metabolite in rats with chemical-induced liver injury.
Topics: 1-Naphthylisothiocyanate; Administration, Oral; Animals; Biotransformation; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Dimethadione; Galactosamine; Injections, Intravenous; Kinetics; Male; Oxazoles; Rats; Time Factors; Trimethadione | 1981 |
Determination of plasma trimethadione and its metabolite carbon tetrachloride-intoxicated rat liver: a useful tool for estimation of hepatic drug metabolizing capacity.
Topics: Animals; Carbon Tetrachloride Poisoning; Cytochrome P-450 Enzyme System; Dimethadione; In Vitro Techniques; Kinetics; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Oxazoles; Oxidoreductases; Rats; Rats, Inbred Strains; Time Factors; Trimethadione | 1981 |
Clinical significance of the trimethadione tolerance test in chronic hepatitis: a useful indicator of hepatic drug metabolizing capacity.
Topics: Chronic Disease; Dimethadione; Drug Tolerance; Female; Hepatitis; Hepatitis B; Hepatitis C; Hepatitis, Chronic; Humans; Kidney Failure, Chronic; Liver; Male; Middle Aged; Trimethadione | 1995 |
Pharmacokinetic study of trimethadione and its metabolite in blood, liver and brain by microdialysis in conscious, unrestrained rats.
Topics: Animals; Anticonvulsants; Brain; Corpus Striatum; Dimethadione; Frontal Lobe; Liver; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Trimethadione | 1995 |
The effects of inhibitors and substrates of different types of cytochrome P450 isozymes on serum dimethadione/trimethadione ratio in rats in vivo.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Dimethadione; Enzyme Inhibitors; Isoenzymes; Male; Rats; Rats, Sprague-Dawley; Substrate Specificity; Trimethadione | 1995 |
Influence of partial hepatectomy in dogs on trimethadione metabolism and microsomal monooxygenases.
Topics: Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dimethadione; Dogs; Enzyme Induction; Hepatectomy; Isoenzymes; Liver; Liver Regeneration; Male; Microsomes, Liver; Oxidation-Reduction; Oxygenases; Steroid 16-alpha-Hydroxylase; Trimethadione | 1995 |
Trimethadione: metabolism and assessment of hepatic drug-oxidizing capacity.
Topics: Animals; Anticonvulsants; Chromatography, Gas; Dimethadione; Humans; In Vitro Techniques; Liver; Liver Diseases; Male; Microsomes, Liver; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Trimethadione | 1996 |
Anticonvulsant drug effects on spontaneous thalamocortical rhythms in vitro: ethosuximide, trimethadione, and dimethadione.
Topics: Animals; Cerebral Cortex; Dimethadione; Dose-Response Relationship, Drug; Ethosuximide; Mice; Mice, Inbred ICR; Rats; Rats, Sprague-Dawley; Thalamus; Trimethadione | 1996 |
Trimethadione metabolism and microsomal monooxygenases in untreated and phenobarbital-treated rhesus monkeys.
Topics: Aniline Hydroxylase; Animals; Anticonvulsants; Cytochrome P-450 Enzyme System; Dimethadione; Enzyme Induction; Isoenzymes; Macaca mulatta; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Trimethadione | 1998 |
The effects of organic solvents on trimethadione n-demethylation in rats.
Topics: Animals; Anticonvulsants; Cytochrome P-450 CYP2E1; Dimethadione; Injections, Intraperitoneal; Male; Microsomes, Liver; Oxidoreductases, N-Demethylating; Rats; Rats, Sprague-Dawley; Solvents; Trimethadione | 1999 |
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Topics: Abnormalities, Drug-Induced; Age Factors; Animals; Anticonvulsants; Arrhythmias, Cardiac; Cation Transport Proteins; Dimethadione; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Fetal Diseases; Fetal Heart; Fetal Hypoxia; Gestational Age; Heart Rate, Fetal; Maternal-Fetal Exchange; Mice; Myocardial Ischemia; Myocardial Reperfusion Injury; Patch-Clamp Techniques; Phenytoin; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pregnancy; Reactive Oxygen Species; Trans-Activators; Trimethadione | 2002 |
[Effect of tridione and dimethadione on blood picture in the white rat; continued investigation].
Topics: Animals; Blood; Dimethadione; Rats; Trimethadione | 1951 |
Co-variation in frequency and severity of cardiovascular and skeletal defects in Sprague-Dawley rats after maternal administration of dimethadione, the N-demethylated metabolite of trimethadione.
Topics: Animals; Bone and Bones; Cardiovascular Abnormalities; Cesarean Section; Dimethadione; Female; Heart; Maternal Exposure; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Trimethadione | 2011 |
Dimethadione embryotoxicity in the rat is neither correlated with maternal systemic drug concentrations nor embryonic tissue levels.
Topics: Animals; Anticonvulsants; Dimethadione; Dose-Response Relationship, Drug; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; Female; Gestational Age; Pregnancy; Rats; Rats, Sprague-Dawley; Trimethadione | 2015 |