diltiazem has been researched along with verapamil in 1413 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 670 (47.42) | 18.7374 |
| 1990's | 478 (33.83) | 18.2507 |
| 2000's | 170 (12.03) | 29.6817 |
| 2010's | 86 (6.09) | 24.3611 |
| 2020's | 9 (0.64) | 2.80 |
| Authors | Studies |
|---|---|
| Chatelain, P; Clinet, M; Gubin, J; Lucchetti, J; Mahaux, J; Nisato, D; Polster, P; Rosseels, G | 1 |
| Barrett, RJ; Johnson, CP; Proakis, AG; Shanklin, JR | 1 |
| Fujiwara, I; Hatano, N; Honda, Y; Kurokawa, M; Mastumoto, J; Naruto, S; Sato, F; Uno, H; Yoshida, T | 1 |
| Adams, TC; Carter, JP; Dupont, AC; Farmer, SG; Guzewska, ME; Kachur, JF; Kaiser, C; Noronha-Blob, L; Rzeszotarski, WJ | 1 |
| Fujita, M; Ito, S; Iwao, J; Kato, N; Kawashima, Y; Ota, A; Yamamoto, K; Yamauchi, H | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Dubinsky, B; Moore, JB; Press, JB; Sanfilippo, PJ; Urbanski, M | 1 |
| Almond, HR; Brannan, MD; Carmosin, RJ; Carson, JR; Flaim, SF; Gill, A; Gleason, MM; Keely, SL; Ludovici, DW; Pitis, PM | 1 |
| Fujita, M; Iso, T; Iwao, J; Kato, E; Kawashima, Y; Oya, M; Tabashi, K; Yamamoto, K | 1 |
| Janis, RA; Triggle, DJ | 1 |
| Botta, M; Bruni, G; Budriesi, R; Campiani, G; Chiarini, A; Fiorini, I; Garofalo, A; Nacci, V; Romeo, MR; Tafi, A | 1 |
| Clinet, M; de Vogelaer, H; Gubin, J; Houben, C; Inion, H; Lucchetti, J; Mahaux, J; Peiren, M; Polster, P; Rosseels, G | 1 |
| Botta, M; Bruni, G; Budriesi, R; Campiani, G; Chiarini, A; Ciani, SM; De Filippis, MP; Fiorini, I; Garofalo, A; Giorgi, G; Manzoni, C; Mennini, T; Nacci, V; Romeo, MR; Sega, A | 1 |
| Gubernator, K; Kansy, M; Senner, F | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Batra, S; Bhaduri, AP; Pandey, VC; Roy, K; Srivastava, P | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Keserü, GM | 1 |
| Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
| Cianchetta, G; Cruciani, G; Fravolini, A; Giesing, D; Singleton, RW; Vaz, RJ; Wildgoose, M; Zhang, M | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Ali, N; Palit, P | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Müller, H; Pick, A; Wiese, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Pratim Roy, P; Roy, K | 1 |
| Globisch, C; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Chen, CY; Kuo, SY; Yang, YH | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Balani, SK; Gan, LS; Li, P; Lu, C | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Bills, GF; de Pedro, N; El Aouad, N; Genilloud, O; Goetz, MA; González-Menéndez, V; Martín, J; Ortiz-López, FJ; Pérez-Victoria, I; Platas, G; Reyes, F; Tormo, JR; Vicente, F | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Budriesi, R; Carosati, E; Chiarini, A; Chiu, FC; Cosimelli, B; Frosini, M; Fusi, F; Ioan, P; Katneni, K; Matucci, R; Micucci, M; Saponara, S; Severi, E; Spinelli, D | 1 |
| Suzuki, K; Toyama, S | 1 |
| Murao, S; Uchida, Y; Yoshimoto, N | 2 |
| Boudot, JP; Cavero, I | 1 |
| Bourassa, MG; Théroux, P | 1 |
| Ikeda, S; Kanazawa, T; Miura, M; Seki, K | 1 |
| Nabata, H | 1 |
| Narimatsu, A; Taira, N | 1 |
| Fleckenstein, A | 1 |
| Camm, AJ; Gill, JS; Ward, DE | 1 |
| Dessy, C; Dion, R; Godfraind, T; Salomone, S; Schoevaerts, JC; Verhelst, B | 1 |
| Schartl, M | 1 |
| Hansen, JF | 3 |
| Lauribe, P; Lévy, S; Malaterre, HR; Paganelli, F; Ramond, B | 1 |
| Li, QP; Liu, TP | 1 |
| Bar Nachum, S; Byk, T; Kleiman, J; Minke, B; Peretz, A; Rom, A; Sahly, I; Selinger, Z; Suss-Toby, E | 1 |
| Brodde, OE; Hundhausen, HJ; Michel, MC; Zerkowski, HR | 1 |
| Araie, E; Miwa, K; Miyagi, Y; Sasayama, S | 1 |
| Crevat, A; Gallice, P; Kovacic, H | 1 |
| Galbani, P; Limbruno, U; Mariani, M; Ronca, G; Ronca-Testoni, S; Yu, G; Zucchi, R | 1 |
| Howlett, SE; Nicholl, PA | 1 |
| Drímal, J | 1 |
| Akaike, N; Kameda, H; Kataoka, M; Takahashi, K; Ueno, S | 1 |
| Lydtin, H; Trenkwalder, P | 1 |
| Arias, IM; Gatmaitan, Z; Hsing, S | 1 |
| Bédard, PJ; Boucher, R; Gomez-Mancilla, B; Latulippe, JF | 1 |
| Montastruc, JL; Senard, JM | 1 |
| Staneva-Stoytcheva, D; Venkova, K | 1 |
| Kamo, N; Komatsubara, M; Miyauchi, S | 1 |
| Eferakeya, AE; Osunkwo, UA | 1 |
| Berga, P; Bou, J; Cardelús, I; Gristwood, RW; Llenas, J | 1 |
| Berga, P; Furman, BL; Gristwood, RW; Jauregui, J; Llenas, J | 1 |
| De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR | 1 |
| Fujiwara, H; Kawai, C; Kawamura, A; Tanaka, M; Uegaito, T | 1 |
| Chopra, H; Fligiel, SE; Hatfield, JS; Honn, KV; Onoda, JM; Rong, X; Taylor, JD; Timar, J | 1 |
| Abiko, Y; Ichihara, K; Nasa, Y; Yoshida, R | 1 |
| Finkel, MS; Oddis, CV; Romeo, RC; Salama, G | 1 |
| Haught, WH; Lawson, DL; Mehta, JL; Yang, BC | 1 |
| Heym, J; McLean, S; Schmidt, AW | 1 |
| Afanas'ev, AIa; Fomichev, VI; Preobrazhenskiĭ, DV | 1 |
| Baeyens, JM; Carlos, R; Del Pozo, E; Ocaña, M | 1 |
| Hayashi, S; Kimura, M; Maeda, K | 1 |
| Bustamante, D; Fernandez, E; Kramer, V; Miranda, HF; Paeile, C; Pelissier, T; Pinardi, G; Saavedra, H | 1 |
| Christ, D; Stillson, T | 1 |
| Grupp, G; Grupp, I; Heikkila, J; Luomanmaki, K; Pesola, MK; Ramo, MP; Schroder, T | 1 |
| Bukovská, A; Edelsteinová, S; Kuzelová, M; Svec, P; Vozár, I | 1 |
| Behrendt, DM; Cobb, SM; Smith, GB; Thompson, SA; Walters, KS | 1 |
| Gu, LM; Xiao, Y; Yuan, F; Zhou, ZN | 1 |
| Guido, S; Joseph, T | 1 |
| Grande, P; Grauholt, AM; Holmvang, L; Lyck, F | 1 |
| Azzarone, A; Borle, AB; Caraceni, P; Fagiuoli, S; Farghali, H; Gasbarrini, A; Starzl, TE; Van Thiel, DH | 1 |
| Achmad, TH; Rao, GS | 1 |
| Nègre-Salvayre, A; Salvayre, R | 1 |
| Alder, VA; Cringle, SJ; Su, EN; Yu, DY | 1 |
| Billman, GE | 1 |
| Fan, SF; Kao, CY | 1 |
| Mason, RP; Moisey, DM; Shajenko, L | 1 |
| Simpson, RU; Taylor, JM | 1 |
| Bertel, O | 1 |
| Tam, IM; Wandres, DL | 1 |
| Lang, F; Waldegger, S; Weiss, H; Wöll, E | 1 |
| Hashimoto, H; Hirano, M; Konishi, K; Utsunomiya, H | 1 |
| Boehme, P; Mak, IT; Weglicki, WB | 1 |
| Abernethy, DR; Andrawis, NS; Craft, N | 1 |
| Danis, M; Dukes, GE; Hak, LJ; Han, YH; Hermann, DJ; Hussey, EK; Krol, TF; Powell, JR | 1 |
| Larochelle, P | 1 |
| Kusniec, J; Rechavia, E; Sclarovsky, S; Strasberg, B | 1 |
| Gürdal, H; Sara, Y; Tulunay, FC | 1 |
| Amobi, NI; Smith, IC | 1 |
| Rao, GH; Smith, CM; White, JG | 1 |
| Findlay, JD; Pullar, IA | 1 |
| Briggs-Tung, C; Cartee, GD; Holloszy, JO | 1 |
| Keith, RA; Mangano, TJ; Patel, J; Salama, AI | 1 |
| Glossmann, H; Knaus, HG; Staudinger, R | 1 |
| Hashimoto, K; Satoh, H | 1 |
| Chandrasekar, B; Korc, M; Siwik, SA | 1 |
| Lepor, H; Rosenthal, E; Shapiro, E; Tang, R | 1 |
| Eckardt, H; Filipovic, I | 1 |
| Grady, DR; Janowsky, DS; Rezvani, AH | 1 |
| Hofmann, F; Regulla, S; Schneider, T | 1 |
| Keith, RA; Moore, WC; Patel, J; Salama, AI | 1 |
| Lipton, SA | 1 |
| Mustafa, AA | 1 |
| Choi, YK; Kim, JW; Kim, KW; Kim, SW; Kim, YS; Yang, IM | 1 |
| Pezzola, A; Popoli, P; Sagratella, S; Scotti de Carolis, A; Zeng, YC | 1 |
| Arai, Y; Inudoh, S; Kizawa, Y; Matsuura, R; Murakami, H; Ohura, M; Tsukimura, T; Uemura, Y | 1 |
| Raij, L; Shultz, PJ | 1 |
| Beech, DJ; Bolton, TB; Christen, MO; MacKenzie, I | 1 |
| Böhm, M; Erdmann, E; Schwinger, RH | 3 |
| Herring, GM; Kennedy, KA; Lazo, JS; Schisselbauer, JC | 1 |
| Cheng, CH; Chow, WH; Fong, PC; Lau, CP; Tai, YT | 1 |
| Fox, R; Markham, A; Morgan, R | 1 |
| Brent, LH; Bubien, JK; Butler, JL; Woods, WT | 1 |
| Naitoh, T; Sugimoto, T; Toyo-Oka, T | 1 |
| Baydoun, AR; Markham, A; Morgan, RM; Sweetman, AJ | 1 |
| Ballesta, JJ; Garcia, AG; Gutierrez, LM; Hidalgo, MJ; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Kimura, T; Mukaiyama, O; Satoh, E; Satoh, S | 1 |
| Högestätt, ED; Skärby, TV | 1 |
| Blanco, I; Rodriguez, J; Rodriguez, R; Sabriá, J; Toledo, A | 1 |
| Hashimoto, H; Nakashima, M | 2 |
| Arita, Y; Kimura, T; Nawata, H; Ogami, Y; Yazu, T | 1 |
| Tan, SY; Tepperman, BL; Whittle, BJ | 1 |
| Löw-Friedrich, I; Schoeppe, W | 1 |
| Dhawan, KN; Gupta, GP; Gurtu, S; Roychowdhary, AK; Sinha, JN | 1 |
| Baeyens, JM; Barrios, M | 2 |
| Ferrari, R; Visioli, O | 1 |
| Persson, S | 1 |
| Rampe, D; Triggle, DJ; Zheng, W | 1 |
| Gambini, F; Gaviraghi, G; Micheli, D; Quartaroli, M; Tarter, G; Trist, DG | 1 |
| Clozel, JP; Hess, P; Véniant, M; Wolfgang, R | 1 |
| Belousov, Y; Kushnaryov, V | 1 |
| Hoberg, E; Kübler, W | 2 |
| Brown, EJ; Rosales, C | 1 |
| Shimizu, M; Yamawaki, S | 1 |
| Abbate, R; Boddi, M; Coppo, M; Gensini, GF; Neri Serneri, GG; Prisco, D; Rostagno, C | 1 |
| Kurihara, K; Shoji, T | 1 |
| Aupetit, JF; Faucon, G; Gerentes-Chassagne, I; Kioueh, I; Larbre, JP; Loufoua-Moundanga, J; Timour, Q | 1 |
| Anfossi, G; Burzacca, S; Cavalot, F; Massucco, P; Mattiello, L; Mularoni, E; Trovati, M | 1 |
| Arakawa, T; Durbin, T; Fukuda, T; Mach, T; Tarnawski, A | 1 |
| Coronel, R; Heijnis, JB; van Zwieten, PA | 1 |
| Hartz, PA; Wilson, PD | 1 |
| Gheorghiade, M | 1 |
| Gustafson, KS; Melemed, A; Sulciner, D; Tolins, JP; Vercellotti, GM | 1 |
| Balaraman, V; Claybaugh, JR; Ichimura, WM; Kullama, LK; Nakamura, KT; Pichoff, BE | 1 |
| Angus, JA; Coe, SA; Kawabata, H; Knight, KR; O'Brien, BM | 1 |
| Jankowska, E; Kostowski, W; Pucilowski, O | 1 |
| Gaggi, R; Gianni, AM | 2 |
| Lenzen, R; Stremmel, W; Strohmeyer, G | 1 |
| Blue, PW; Hallgren, SE; Yavorski, RT | 1 |
| Fabrègues, E; John, GW; Kamal, M; Massingham, R | 1 |
| Akita, S; Fujii, K; Kawahara, M; Morio, M | 1 |
| Rabkin, SW | 1 |
| Crosland, RD | 1 |
| Gambone, LM; Schoffstall, JM; Shaw, RP; Sit, SP; Spivey, WH | 1 |
| Boucher, M; Dubray, C; Duchêne-Marullaz, P | 1 |
| Auch-Schwelk, W; Vanhoutte, PM | 2 |
| Cirillo, R; Franzone, JS; Reboani, MC | 1 |
| Filep, JG; Földes-Filep, E | 1 |
| Toshima, H | 1 |
| Anderson, S | 1 |
| Takabatake, Y | 1 |
| Bahls, FH; Ozuna, J; Ritchie, DE | 1 |
| Christensen, C | 1 |
| al-Humayyd, MS | 1 |
| Pedrinelli, R; Salvetti, A | 1 |
| Fromm-Freeck, S; Hayes, L; Howe, BB; Kau, ST; Kitada, S; Levin, RM; Wein, AJ | 1 |
| Alkan, M; Dana, R; Gold, B; Levy, R; Schlaeffer, F | 1 |
| Calder, LD; Karler, R; Partlow, LM; Turkanis, SA | 1 |
| Seymour, RA | 1 |
| Chugh, Y; Datta, H; Saha, N; Sankaranarayanan, A | 1 |
| Adamantidis, M; Dupuis, B; Honoré, E; Libersa, C; Rouet, E | 1 |
| Furui, H; Furumichi, T; Saito, H; Yamada, Y; Yamauchi, K; Yokota, M | 1 |
| Albessard, F; Belin, A; Breut, C; Grieu, P; Grollier, G; Kleszcz, A; Mabire, JP; Potier, JC; Scanu, P; Sesboué, B | 1 |
| Iso, T; Miyawaki, N; Nishimura, K; Yamauchi, H | 1 |
| Furui, H; Furumichi, T; Hayashi, H; Saito, H; Suzuki, T; Yamada, Y; Yamauchi, K; Yokota, M | 1 |
| Iwata, K; Sasaki, Y | 1 |
| Koleva, M; Stoytchev, T | 2 |
| Rogério, R; Takahashi, RN | 1 |
| Fanburg, BL; Hill, NS; Lee, SL | 1 |
| Beaufort, P; Chatelain, P; Clinet, M; Laruel, R; Meysmans, L; Nokin, P | 1 |
| Campisi, D; Cascio Ingurgio, N; Marsala, BA; Martino, SG; Paterna, S | 1 |
| Raess, BU; Record, DM | 1 |
| Goldhammer, E; Sharma, SK; Silke, B; Taylor, SH; Verma, SP | 1 |
| Köhler, H; Marx, M; Merkel, F; Meyer zum Büschenfelde, KH; Weber, M | 1 |
| Harada, Y; Kimura, R; Nakayama, K; Yamada, S | 1 |
| Gazmuri, RJ; Rackow, EC; Ritz, MA; von Planta, M; Weil, MH | 1 |
| Kaplan, DS; King, RL; Levine, RA; Nandi, J | 1 |
| Andreeva, TN | 1 |
| Endoh, M; Hiramoto, T; Kushida, H | 1 |
| Locher, R; Sachinidis, A; Steiner, A; Vetter, W | 1 |
| Glossmann, H; Knaus, HG; Romanin, C; Scheffauer, F; Schindler, HG | 1 |
| Akaike, N; Kanaide, H; Kuga, T; Nakamura, M; Sadoshima, J; Tomoike, H | 1 |
| Dudkin, SM; Polev, PV; Soldatov, NM | 1 |
| Mironneau, C; Mironneau, J; Rakotoarisoa, L; Sayet, I | 1 |
| Ballard, HS; Haakenson, CM; Johnson, GJ; Moritz, TE; O'Donnell, JF; Ringenberg, QS; Schilsky, RL; Spaulding, MB; Tornyos, K; Zacharski, LR | 1 |
| Morrissey, J; Ritter, C; Slatopolsky, E; Sugimoto, T | 1 |
| Gordon, T; Howlett, SE | 1 |
| Ando, H; Hanamura, Y; Ishikawa, K; Takasu, H; Takeuchi, M; Tsuda, T | 1 |
| Dirschinger, J; Hall, D; Kraus, F; Rudolph, W | 1 |
| Fridrich, L; Gassner, A; Magometschnigg, D; Priol, A; Sommer, G | 1 |
| Bidzinski, A; Jankowska, E; Pucilowski, O | 1 |
| Abbate, R; Boddi, M; Costanzo, G; Paniccia, R; Poggesi, L; Prisco, D; Rostagno, C | 1 |
| Baumelou, A; Baumelou, B; Cacoub, P; Deray, G; Jacobs, C; Martinez, F | 1 |
| Bazill, GW; Dexter, TM | 1 |
| Czuczwar, SJ; Kleinrok, Z; Małek, U | 1 |
| Chojnacki, J; Kula, Z | 1 |
| Alle, M; Cieslinski, G; Kaltenbach, M; Kober, G; Noack, H; Reifart, N; Roebruck, P; Schneider, W | 1 |
| Huff, MR; Maduh, EU | 1 |
| Mironova, MI; Paskhina, OE | 1 |
| Baeyens, JM; Del Pozo, E; Ruiz-García, C | 1 |
| Bauer, JH; Reams, GP | 2 |
| Hunter, JB; Pegram, BL; Peters, T; Scheufler, E; Vogelgesang, R; Wermelskirchen, D; Wilffert, B | 1 |
| Doi, S; Hagiwara, A; Izumo, A; Kato, M; Tanabe, K | 1 |
| Coetzee, WA; Dennis, SC; Opie, LH; Owen, P; Saman, S | 1 |
| Abe, T; Fujii, Y; Fujioka, S; Ina, H; Maseki, T; Yoshida, K | 1 |
| Gottschalk, F; Morris, AC; Padalino, PK; Pak, CY; Zerwekh, JE | 1 |
| Atlee, JL; Bosnjak, ZJ; Yeager, TS | 1 |
| Myers, A; Ramoska, EA; Spiller, HA | 1 |
| Bottorff, MB; Herring, VL; Hunt, BA; Lalonde, RL; Self, TH | 1 |
| Uematsu, T; Yamaguchi, M | 1 |
| Kashimoto, S; Kumazama, T; Kume, M; Oguchi, T | 1 |
| Peters, T; Scheufler, E | 1 |
| Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G | 1 |
| Brunt, RV; Griffiths, EJ | 1 |
| Lollike, K; Treiman, M; von Spreckelsen, S | 1 |
| Lundström, T; Rydén, L | 1 |
| Chapin, RE; Ghanayem, BI | 1 |
| Cattaneo, EA; Cingolani, HE; Rinaldi, GJ | 1 |
| Francis, GS; Johnson, GJ; Leis, LA | 1 |
| Kato, H; Takata, Y | 4 |
| Abraham, WM; Ahmed, T | 1 |
| Auclair, MC; Lechat, P; Vernimmen, C | 1 |
| Huff, JW; Reinach, PS | 1 |
| Brouwer, RM; Bühler, FR; Follath, F | 1 |
| Ram, CV | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 2 |
| Ducreux, C; Gola, M | 1 |
| Falotico, R; Fuller, BL; Moore, JB; Tolman, EL | 1 |
| García de Jalón, PD; Manso, G | 1 |
| Bryant, SH; Schwartz, A; Walsh, KB | 1 |
| Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
| Berman, BA; Ross, RN | 1 |
| Hattori, Y; Hazama, S; Kanno, M; Nakao, Y | 1 |
| Kojima, M; Sperelakis, N | 1 |
| Dreyer, F; Penner, R | 1 |
| Cargnoni, A; Ciampalini, G; Ferrari, R; Raddino, R; Rodella, A | 1 |
| Akaike, N; Kuraoka, S; Nishi, K; Oyama, Y | 1 |
| Garcia, ML; Kaczorowski, GJ; King, VF; Reuben, JP; Siegl, PK | 1 |
| Greenberg, DA | 1 |
| Conte-Camerino, D; De Luca, A; Lograno, M; Persichella, M | 1 |
| Froldi, M; Leggieri, E; Lorini, M; Miadonna, A; Tedeschi, A; Zanussi, C | 1 |
| Carvalho, AP; Carvalho, CA; Coutinho, OP | 1 |
| Andresen, MC; Kunze, DL; Torres, LA | 1 |
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| Elston Lafata, J; Horn, JR; Kaatz, S; Raebel, MA; Schultz, L; Simpkins, J; Smith, DH; Yood, MU | 1 |
| Fiszer, M; Kołaciński, Z; Rechciński, T | 1 |
| Boyer, EW; Geib, AJ; Levine, M; Mick, N; Pozner, CN; Thomas, SH; Thomsen, T | 1 |
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| Ayres, JW; Christensen, JM; Nguyen, CN | 1 |
| Borowicz, KK; Czuczwar, SJ; Kimber-Trojnar, Z; Luszczki, JJ; Szostakiewicz, B; Trojnar, MK; Trojnar, MP; Zadrozniak, A | 1 |
| Doom, CM; Maruyama, KP; Nanigian, DB; Sorkin, LS | 1 |
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| Daveluy, A; Girodet, PO; Haramburu, F; Miremont-Salamé, G; Molimard, M; Moore, N; Raignoux, C | 1 |
| Bashir, ZI; Brown, MW; Keen, H; Massey, PV; Seoane, A | 1 |
| Bajuszova, Z; Klimas, J; Krenek, P; Kyselovic, J; Ochodnicky, P; Vaja, V | 1 |
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| Chen, YC; Chen, YW; Chu, CC; Hung, CH; Wang, JJ | 1 |
| Alcalai, R; Arad, M; Berul, CI; Konno, T; Planer, D; Seidman, CE; Seidman, JG; Wakimoto, H; Wang, L | 1 |
| Hosoi, Y; Kanamaru, T; Konno, T; Nakagami, H; Tajiri, S; Yada, S; Yoshida, K | 1 |
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| Bergmann, I; Deters, M; Enden, G; Hentschel, H; Kutz, S; Liebetrau, G; Plenert, B; Prasa, D | 1 |
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| Cabello, S; Cabrera, Mde L; González, A; Márquez, S; Mellado, M; Moenne, A; Morales, B | 1 |
| Furrer, F; Giambarba, C | 1 |
| Aykur, M; Kayan, M; Nazıroğlu, M; Ovey, IS; Uğuz, AC; Yürekli, VA | 1 |
| Dong, L; Ge, J; Ge, L; Huang, D; Jin, H; Jin, X; Liu, Z; Ma, J; Qian, J; Wang, X; Yao, K; Zhang, F | 1 |
| Drożdż, J; Filipiak, KJ; Grajek, S; Kasprzak, JD; Opolski, G; Rynkiewicz, A; Stępińska, J; Tykarski, A; Wożakowska Kapłon, B | 1 |
| He, Q; Mei, XB; Wang, QQ; Wang, T; Wen, XJ; Xiao, L; Zhang, LM; Zhao, J; Zheng, JM | 1 |
| Benjamin Guise, J; Bickel, W; Brooks Gentry, W; Cargile, C; Mancino, M; Oliveto, A; Sanders, N | 1 |
| Olson, KR | 1 |
| Curry, SC; Levine, M; Padilla-Jones, A; Ruha, AM | 1 |
| Chengliang, Z; Dong, L; Tao, W; Xiping, L; Xiuhua, R; Yanjiao, X | 1 |
| Gao, M; Kong, SK; Lau, PM; Wong, SY | 1 |
| Pfeffer, AN; Williams, SR | 2 |
| Allouch, P; Arnould, MA; Barbou, F; Chaïb, A; Huber, A; Jégou, A; Mihoub, F; Rosencher, J; Salengro, E; Varenne, O; Zuily, S | 1 |
| Broadbent, J | 1 |
| Aykur, M; Kutluhan, S; Naziroglu, M; Ovey, IS; Yurekli, VA | 1 |
| Abdelnoor, M; Arnesen, H; Enger, S; Gjesdal, K; Pripp, AH; Tveit, A; Ulimoen, SR | 1 |
| Linnet, K; Rasmussen, HB; Thomsen, R | 1 |
| Adeneye, AA; Akindele, AJ; Benebo, AS; Olatoye, F | 1 |
| Kawasaki, T; Sugihara, H | 1 |
| Aykur, M; Güney, M; Kaplan, Ö; Nazıroğlu, M | 1 |
| Chan, TB; Chan, YC; Lau, FL | 1 |
| Curry, S; Levine, M; Padilla-Jones, A; Ruha, AM | 1 |
| Cole, JB; Engebretsen, KM; Holger, JS; Kerns, W; Stellpflug, SJ | 1 |
| Kline, JA | 1 |
| Curry, SC; Levine, M; Ruha, AM | 1 |
| Abdelnoor, M; Arnesen, H; Enger, S; Gjesdal, K; Norseth, J; Pripp, AH; Tveit, A; Ulimoen, SR | 1 |
| Bispo-da-Silva, LB; da Silveira, NS; de Oliveira-Silva, GL; Lamanes, Bde F; Prado, LC | 1 |
| Cigarroa, JE; Gupta, S | 1 |
| Corino, VD; Enger, S; Mainardi, LT; Platonov, PG; Tveit, A; Ulimoen, SR | 1 |
| Barceló, D; Esplugas, S; Gonzalez, O; Pérez, S; Qiang, Z; Sans, C; Xu, K; Zhu, B; Zonja, B | 1 |
| Baba, A; Kazama, I; Maruyama, Y; Tachi, M | 1 |
| Cheng, Z; Gu, Y; Peng, D; Wang, L | 1 |
| Chang, Y; Chu, L; Chu, X; Gao, Y; Guo, H; Liu, Z; Wang, N; Zhang, J; Zhang, X; Zhang, Y; Zhao, X | 1 |
| Arnesen, H; Enger, S; Horjen, AW; Norseth, J; Seljeflot, I; Tveit, A; Ulimoen, SR | 1 |
| Baryshnikova, GA; Blochina, OE; Chorbinskayva, SA; Korchazhkina, NB; Maslennikova, OM; Maslovskyi, LV; Stepanova, II; Zverkov, IV | 1 |
| Borlak, J; Zwadlo, C | 1 |
| Abbott, S; Schultz, AV; Waraczynski, M | 1 |
| Bibas, L; Essebag, V; Levi, M | 1 |
| Becker, RC; Berkowitz, SD; Breithardt, G; Fox, KAA; Halperin, JL; Hankey, GJ; Hellkamp, AS; Lokhnygina, Y; Mahaffey, KW; Nessel, CC; Patel, MR; Piccini, JP; Singer, DE; Washam, JB | 1 |
| Hong, JM; Kim, J; Lee, SH; Ok, SH; Park, J; Shin, IW; Sohn, JT; Woo, MS | 1 |
| Brubaker, S; Koyfman, A; Long, B | 1 |
| Ding, WG; Hoshino, S; Maruo, Y; Matsuura, H; Nakagawa, M; Omatsu-Kanbe, M; Sagawa, H; Yoshioka, K | 1 |
| Alnajjar, LM; Bulatova, NR; Darwish, RM | 1 |
| Aimoto, M; Cao, X; Ishiguro, A; Nagasawa, Y; Nozaki, S; Okamura, K; Takahara, A | 1 |
| Baltzer, AB; Buhl, T; Forkel, S; Geier, J | 1 |
| Chen, J; Hayashi, S; Iribe, G; Kaihara, K; Miyajima, M; Morimatsu, M; Naruse, K; Omori, M; Sokabe, M; Takahashi, K; Wang, C; Wang, J | 1 |
| Belbachir, N; Kitani, T; Lam, CK; Ma, N; Rhee, JW; Shrestha, R; Tian, L; Wnorowski, A; Wu, JC | 1 |
| Gao, S; Huang, G; Lei, J; Wu, J; Wu, Q; Yan, N; Yan, Z; Zhao, Y | 1 |
| Catterall, WA; Gamal El-Din, TM; Lenaeus, MJ; Tang, L; Zheng, N | 1 |
| Andrews, LM; Koch, BCP; van der Nagel, BCH; van Domburg, B | 1 |
| Dickinson, GL; Hall, SD; Kulanthaivel, P; Morse, BL; Posada, MM; Turner, PK | 1 |
| Brown, JD; Lesko, L; Lip, GYH; Pham, P; Schmidt, S | 1 |
| Berei, TJ; Chappell, RJ; Du, L; Goldberger, ZD; Rajput, FA; Wright, JM | 1 |
| Duan, X; Gui, Y; Jia, J; Li, S; Liu, CC; Liu, G; Lu, Y; Zhang, M | 1 |
| Balaji, U; Chang, Y; Gu, J; Nelson, M; Odiase, E; Pan, Z; Souza, RF; Spechler, SJ; Zhang, Q; Zhang, X | 1 |
| Gaidin, SG; Kosenkov, AM; Laryushkin, DP; Maiorov, SA; Zinchenko, VP | 1 |
| Bajpai, SK; Edwina, P; Roy, B; Sivasubramaniapandian, M; Vaibavi, SR; Vaippully, R | 1 |
| Meyer, M; Roetker, NS; Weinhandl, ED; Wetmore, JB | 1 |
| Casanova, EM; Clark, NP; Delate, T; Drees, ET; Ekmekdjian, H; Hui, R; Niu, F; Pontoppidan, K; Teshima, SSM | 1 |
180 review(s) available for diltiazem and verapamil
| Article | Year |
|---|---|
New developments in Ca2+ channel antagonists.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calmodulin; Electrophysiology; Heart; Humans; Ion Channels; Muscle Relaxation; Muscle, Smooth; Potassium; Sodium; Structure-Activity Relationship; Substrate Specificity | 1983 |
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Fundamental cardiac and vascular effects of Ca++-antagonistic coronary drugs].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Biological Transport; Calcium; Cats; Chemical Phenomena; Chemistry; Coronary Vessels; Diltiazem; Dose-Response Relationship, Drug; Gallopamil; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Contraction; Myocardium; Nifedipine; Oxygen Consumption; Phenethylamines; Prenylamine; Rabbits; Swine; Verapamil | 1975 |
Calcium antagonists in the treatment early after myocardial infarction. The DEFIANT Research Group.
Topics: Adult; Aged; Calcium Channel Blockers; Denmark; Diltiazem; Echocardiography, Doppler; Humans; Middle Aged; Myocardial Contraction; Myocardial Infarction; Random Allocation; Ventricular Function, Left; Verapamil | 1992 |
[Parkinson syndrome, a possible adverse effect of calcium inhibitors].
Topics: Aged; Calcium Channel Blockers; Diltiazem; Female; Humans; Male; Parkinson Disease, Secondary; Verapamil | 1992 |
[Calcium channel blockers and prevention of migraine].
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Diltiazem; Flunarizine; Humans; Migraine Disorders; Nifedipine; Nimodipine; Verapamil | 1992 |
[Effects of calcium antagonists on carbohydrate and lipid metabolism].
Topics: Animals; Calcium Channel Blockers; Carbohydrate Metabolism; Cholesterol; Coronary Disease; Diabetes Mellitus; Diltiazem; Glucose; Glucose Tolerance Test; Homeostasis; Humans; Insulin; Lipid Metabolism; Lipids; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Nifedipine; Verapamil | 1992 |
Calcium-channel blockers and gingival hyperplasia.
Topics: Aged; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Female; Gingival Hyperplasia; Humans; Male; Middle Aged; Nifedipine; Recurrence; Time Factors; Verapamil | 1992 |
Renal tubular effects of calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Diuresis; Humans; Kidney Tubules; Natriuresis; Verapamil | 1992 |
Protective effects of calcium antagonists against ischaemia and reperfusion damage.
Topics: Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Humans; Myocardial Reperfusion Injury; Nifedipine; Verapamil | 1991 |
Calcium antagonists in secondary prevention after myocardial infarction.
Topics: Calcium Channel Blockers; Diltiazem; Female; Humans; Male; Meta-Analysis as Topic; Myocardial Infarction; Nifedipine; Recurrence; Verapamil | 1991 |
Prevention of restenosis after PTCA: role of calcium antagonists.
Topics: Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Coronary Disease; Diltiazem; Double-Blind Method; Female; Humans; Male; Middle Aged; Nifedipine; Recurrence; Risk Factors; Verapamil | 1991 |
Calcium channel blockers in the management of myocardial infarction patients.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Verapamil | 1991 |
Calcium-antagonists in preventing restenosis following coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Humans; Nifedipine; Recurrence; Verapamil | 1991 |
Calcium antagonists and myocardial infarction.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Verapamil | 1991 |
[Interaction between calcium antagonists and digoxin].
Topics: Atrial Fibrillation; Calcium Channel Blockers; Digoxin; Diltiazem; Drug Interactions; Humans; Nifedipine; Verapamil | 1991 |
Calcium channel blockers and gingival overgrowth.
Topics: Calcium Channel Blockers; Cyclosporins; Diltiazem; Fibroblasts; Gingival Hyperplasia; Humans; Nifedipine; Vasodilation; Verapamil | 1991 |
[Treatment of heart failure with calcium antagonists].
Topics: Calcium Channel Blockers; Diltiazem; Heart Failure; Hemodynamics; Humans; Myocardial Contraction; Nifedipine; Verapamil | 1990 |
[Calcium antagonists and the digestive system].
Topics: Digestive System; Digestive System Diseases; Digestive System Physiological Phenomena; Diltiazem; Drug Evaluation; Humans; Nifedipine; Verapamil | 1990 |
Effects of calcium antagonists on the hypertensive kidney.
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Humans; Hypertension; Kidney; Kidney Function Tests; Verapamil | 1990 |
Role of calcium-channel blockers in obstructive airway disease.
Topics: Acetylcholine; Animals; Asthma; Asthma, Exercise-Induced; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Electrolytes; Glycoproteins; Histamine Release; Humans; In Vitro Techniques; Ion Channels; Lung Diseases, Obstructive; Mast Cells; Muscle Contraction; Muscle, Smooth; Nifedipine; Respiration; Respiratory System; Verapamil | 1985 |
Review of the cardiovascular adversity of the calcium antagonist beta-blocker combination: implications for antihypertensive therapy.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Drug Therapy, Combination; Heart Conduction System; Hemodynamics; Humans; Hypertension; Nifedipine; Verapamil | 1985 |
Calcium antagonists in the treatment of hypertension.
Topics: Biological Transport, Active; Calcium; Calcium Channel Blockers; Captopril; Diltiazem; Diuretics; Drug Resistance; Drug Therapy, Combination; Electrophysiology; Humans; Hypertension; Hypertension, Renovascular; Ion Channels; Kinetics; Methyldopa; Muscle, Smooth, Vascular; Nifedipine; Propranolol; Sodium; Vascular Resistance; Verapamil | 1985 |
Treating coexisting cardiovascular and pulmonary disease with calcium antagonists.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Asthma, Exercise-Induced; Bronchial Spasm; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Constipation; Diltiazem; Headache; Heart Conduction System; Humans; Ion Channels; Lung Diseases; Lung Diseases, Obstructive; Nifedipine; Verapamil | 1986 |
[Mechanism of action of calcium-antagonists on the smooth vascular muscles].
Topics: Calcium; Calcium Channel Blockers; Diltiazem; Ion Channels; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Verapamil | 1985 |
Calcium channel antagonists and the treatment of migraine.
Topics: Calcium; Calcium Channel Blockers; Cinnarizine; Diltiazem; Flunarizine; Humans; Ion Channels; Kinetics; Migraine Disorders; Nicotinic Acids; Nifedipine; Nimodipine; Verapamil | 1986 |
Calcium channel blockers. Potential medical benefits and side effects.
Topics: Blood Pressure; Calcium Channel Blockers; Diltiazem; Exercise; Humans; Hypertension; Nifedipine; United States; Verapamil | 1989 |
[Calcium antagonists: accounts on new perspectives of their use and an update on side effects].
Topics: Adult; Animals; Asthma; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Esophageal Achalasia; Female; Humans; Hypertension, Pulmonary; Infant, Newborn; Male; Menstruation Disturbances; Nifedipine; Obstetric Labor, Premature; Pregnancy; Rabbits; Rats; Stomach Ulcer; Verapamil | 1989 |
Calcium channel blockers in myocardial infarction.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Verapamil | 1989 |
[Poisoning with verapamil and other calcium antagonists].
Topics: Animals; Antidotes; Calcium; Calcium Channel Blockers; Diltiazem; Humans; Nifedipine; Prognosis; Rabbits; Rats; Sympathomimetics; Verapamil | 1989 |
Calcium-channel blockers in the management of essential hypertension.
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Humans; Hypertension; Verapamil | 1989 |
Use of calcium channel entry blockers in the treatment of cardiac arrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Electrocardiography; Heart Conduction System; Humans; Tachycardia, Supraventricular; Verapamil | 1989 |
Review of calcium antagonist trials in acute myocardial infarction.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Randomized Controlled Trials as Topic; Verapamil | 1989 |
Receptors for calcium antagonists.
Topics: Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Nifedipine; Receptors, Nicotinic; Verapamil | 1988 |
Large vessel coronary vasospasm: diagnosis, natural history and treatment.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aspirin; Coronary Artery Bypass; Coronary Disease; Coronary Vasospasm; Diltiazem; Electrocardiography; Epoprostenol; Female; Fibrinolytic Agents; Humans; Isosorbide Dinitrate; Male; Nifedipine; Nitrates; Prazosin; Verapamil | 1985 |
Combination therapy with calcium-channel blockers and beta blockers for chronic stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electrophysiology; Hemodynamics; Humans; Male; Nifedipine; Verapamil | 1985 |
Selection of optimal drug therapy for the patient with angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Calcium Channel Blockers; Diabetes Mellitus, Type 1; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Drug Tolerance; Heart Rate; Heart Ventricles; Humans; Hypertension; Kidney Diseases; Lung Diseases; Myocardium; Nifedipine; Nitrates; Physical Exertion; Receptors, Adrenergic, beta; Systole; Vascular Diseases; Vasodilation; Verapamil | 1985 |
Antihypertensive therapy with calcium-channel blockers: comparison with beta blockers.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Drug Therapy, Combination; Europe; Heart Rate; Humans; Hypertension; Nifedipine; United States; Verapamil | 1985 |
Calcium antagonists.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Coronary Vasospasm; Diltiazem; Heart; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nitrates; Oxygen Consumption; Time Factors; Verapamil | 1985 |
[Calcium antagonists in the treatment of arterial hypertension].
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Calcium Channel Blockers; Diltiazem; Diuretics; Drug Therapy, Combination; Humans; Hypertension; Nifedipine; Vasodilator Agents; Verapamil | 1985 |
Calcium channel blockade: central hemodynamic effects.
Topics: Adrenergic beta-Antagonists; Adult; Animals; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Drug Interactions; Heart Rate; Hemodynamics; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Nifedipine; Vasodilation; Verapamil | 1986 |
The haemodynamic effects of nifedipine, verapamil and diltiazem in patients with coronary artery disease. A review.
Topics: Adrenergic beta-Antagonists; Benzazepines; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Drug Interactions; Heart; Hemodynamics; Humans; Myocardium; Nifedipine; Verapamil | 1986 |
Combined use of calcium-channel and beta-adrenergic blockers for the treatment of chronic stable angina. Rationale, efficacy, and adverse effects.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Drug Therapy, Combination; Humans; Nifedipine; Verapamil | 1988 |
Effects of calcium entry blockers on renin-angiotensin-aldosterone system, renal function and hemodynamics, salt and water excretion and body fluid composition.
Topics: Animals; Blood Pressure; Body Fluids; Calcium Channel Blockers; Diltiazem; Diuresis; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Nifedipine; Nitrendipine; Renal Circulation; Renin-Angiotensin System; Verapamil; Water-Electrolyte Balance | 1985 |
Influence of calcium-channel blockers on platelet function and arachidonic acid metabolism.
Topics: Animals; Arachidonic Acids; Blood Platelets; Calcium; Calcium Channel Blockers; Cyclic AMP; Diltiazem; Dogs; Drug Interactions; Humans; Nifedipine; Platelet Aggregation; Verapamil | 1985 |
[Calcium antagonists in acute myocardial infarction].
Topics: Calcium Channel Blockers; Diltiazem; Gallopamil; Hemodynamics; Humans; Myocardial Infarction; Nifedipine; Verapamil | 1988 |
[Calcium antagonists in arterial hypertension].
Topics: Calcium Channel Blockers; Diltiazem; Drug Interactions; Heart Diseases; Hemodynamics; Humans; Hypertension; Nifedipine; Verapamil | 1988 |
[Calcium antagonists in congestive heart failure].
Topics: Calcium Channel Blockers; Cardiomyopathy, Dilated; Diltiazem; Felodipine; Heart Failure; Hemodynamics; Humans; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Verapamil | 1988 |
Calcium channel antagonists. Part II: Use and comparative properties of the three prototypical calcium antagonists in ischemic heart disease, including recommendations based on an analysis of 41 trials.
Topics: Angina Pectoris; Angina, Unstable; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Therapy, Combination; Humans; Meta-Analysis as Topic; Myocardial Infarction; Nifedipine; Propranolol; Verapamil | 1988 |
Geriatric hypertension: the growing use of calcium-channel blockers.
Topics: Aged; Calcium; Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Nifedipine; Verapamil | 1988 |
Glucagon antagonism of calcium channel blocker-induced myocardial dysfunction.
Topics: Animals; Coronary Circulation; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Glucagon; Hemodynamics; Infusion Pumps; Male; Myocardial Contraction; Nifedipine; Rats; Verapamil | 1988 |
The role of calcium channel blockers in the treatment of hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Follow-Up Studies; Heart Rate; Hemodynamics; Humans; Hypertension; Kidney; Kinetics; Labetalol; Nifedipine; Sympathetic Nervous System; Verapamil | 1986 |
Calcium channel blocking agents in congestive heart failure.
Topics: Administration, Oral; Biological Transport; Calcium; Calcium Channel Blockers; Cardiac Output; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Heart Failure; Heart Ventricles; Hemodynamics; Humans; Infusions, Parenteral; Myocardial Contraction; Myocardium; Nifedipine; Oxygen Consumption; Physical Exertion; Pulmonary Edema; Time Factors; Verapamil | 1986 |
Kinetics and dynamics of calcium entry antagonists in systemic hypertension.
Topics: Administration, Oral; Animals; Calcium Channel Blockers; Diltiazem; Half-Life; Hemodynamics; Humans; Hypertension; Infusions, Parenteral; Injections, Intravenous; Kinetics; Liver Circulation; Nifedipine; Verapamil | 1986 |
Review of calcium-channel blockers.
Topics: Angina Pectoris; Calcium Channel Blockers; Diltiazem; Humans; Nifedipine; Verapamil | 1986 |
Advances in calcium blocker therapy.
Topics: Arrhythmias, Cardiac; Arteriosclerosis; Asthma; Blood Platelet Disorders; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Coronary Disease; Diltiazem; Gastrointestinal Diseases; Heart Failure; Humans; Hypertension; Kinetics; Nifedipine; United States; Vascular Diseases; Verapamil | 1986 |
Mechanisms involved in reperfusion arrhythmias.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Heart Conduction System; Humans; Nifedipine; Perfusion; Platelet Aggregation; Ventricular Fibrillation; Verapamil | 1986 |
Calcium channel blockers in systemic hypertension.
Topics: Animals; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Drug Interactions; Humans; Hypertension; Nifedipine; Rats; Verapamil | 1986 |
Calcium antagonists and glycaemic control.
Topics: Blood Glucose; Calcium Channel Blockers; Diabetes Mellitus; Diltiazem; Glucose Tolerance Test; Humans; Nifedipine; Verapamil | 1986 |
Calcium antagonists and chronic cardiac failure.
Topics: Calcium Channel Blockers; Chronic Disease; Diltiazem; Heart Failure; Humans; Nifedipine; Verapamil | 1986 |
Treatment of angina pectoris and hypertension with sustained-release calcium channel-blocking drugs.
Topics: Angina Pectoris; Biological Availability; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Verapamil | 1987 |
Secondary prevention with calcium channel-blocking drugs in patients after myocardial infarction: a critical review.
Topics: Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Recurrence; Verapamil | 1987 |
The role of calcium entry blockers in hypertensive emergencies.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Emergencies; Humans; Hypertension; Nifedipine; Verapamil | 1987 |
Calcium antagonists in patients with cardiovascular disease. Current perspectives.
Topics: Angina Pectoris; Angina Pectoris, Variant; Atrial Fibrillation; Atrial Flutter; Benzazepines; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Diltiazem; Drug Interactions; Heart Failure; Humans; Hypertension; Hypertension, Pulmonary; Kinetics; Nifedipine; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1985 |
Calcium antagonists for acute ischemic heart disease.
Topics: Acute Disease; Angina Pectoris, Variant; Angina, Unstable; Calcium Channel Blockers; Coronary Disease; Diltiazem; Electrocardiography; Humans; Myocardial Infarction; Nifedipine; Syndrome; Verapamil | 1985 |
Raynaud's phenomenon: pathophysiologic features and treatment with calcium-channel blockers.
Topics: Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Female; Humans; Male; Nifedipine; Prospective Studies; Random Allocation; Raynaud Disease; Verapamil | 1985 |
Modification of experimental atherosclerosis by calcium-channel blockers.
Topics: Animals; Aorta; Arteriosclerosis; Calcium; Calcium Channel Blockers; Child; Diet, Atherogenic; Diltiazem; Disease Models, Animal; Humans; Macaca; Nifedipine; Rabbits; Rats; Verapamil | 1985 |
Therapeutic application of calcium-channel antagonists for pulmonary hypertension.
Topics: Animals; Calcium Channel Blockers; Cattle; Diltiazem; Hemodynamics; Humans; Hypertension, Pulmonary; Hypoxia; Lung; Lung Diseases, Obstructive; Nifedipine; Rats; Vasoconstriction; Verapamil | 1985 |
Calcium-channel blocking agents for gastrointestinal disorders.
Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Esophageal Achalasia; Esophagus; Gastrointestinal Diseases; Humans; Muscle, Smooth; Nifedipine; Opossums; Papio; Peristalsis; Verapamil | 1985 |
Pharmacokinetics of calcium-entry blockers.
Topics: Absorption; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Drug Interactions; Half-Life; Humans; Kinetics; Nifedipine; Time Factors; Tissue Distribution; Verapamil | 1985 |
Use of calcium antagonists in ventricular dysfunction.
Topics: Calcium Channel Blockers; Diltiazem; Heart Diseases; Heart Ventricles; Hemodynamics; Humans; Hypertension; Myocardial Infarction; Nifedipine; Verapamil | 1985 |
Are calcium antagonists cardioprotective?
Topics: Angina Pectoris; Animals; Blood Viscosity; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Diltiazem; Heart; Humans; Hypertension; Myocardial Contraction; Myocardial Infarction; Nifedipine; Platelet Aggregation; Verapamil | 1985 |
Calcium channel blocking agents: physiologic basis of nursing intervention.
Topics: Angina Pectoris; Angina Pectoris, Variant; Atrioventricular Node; Calcium; Calcium Channel Blockers; Cardiomyopathies; Cardiomyopathy, Hypertrophic; Coronary Disease; Diltiazem; Electrophysiology; Humans; Hypertension; Myocardial Contraction; Nifedipine; Sinoatrial Node; Tachycardia; Vascular Resistance; Verapamil | 1985 |
Combination therapy with isosorbide dinitrate: current status and the future.
Topics: Angina Pectoris; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Esophageal Achalasia; Exercise Test; Heart Failure; Humans; Hydralazine; Isosorbide Dinitrate; Nifedipine; Nitroprusside; Propranolol; Verapamil | 1985 |
Atherosclerosis, calcium, and calcium antagonists.
Topics: Animals; Aorta; Arteries; Arteriosclerosis; Calcinosis; Calcium; Calcium Channel Blockers; Cell Survival; Cholesterol, Dietary; Cinnarizine; Diltiazem; Flunarizine; Humans; Membrane Lipids; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Propranolol; Rabbits; Verapamil | 1985 |
Response of normal and diseased epicardial coronary arteries to vasoactive drugs: quantitative arteriographic studies.
Topics: Arterial Occlusive Diseases; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Coronary Vessels; Diltiazem; Hemodynamics; Humans; Isometric Contraction; Nifedipine; Radiography; Vascular Resistance; Vasodilator Agents; Verapamil | 1985 |
Pharmacokinetics of diltiazem and other calcium entry blockers.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Benzazepines; Blood Proteins; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Diltiazem; Drug Interactions; Humans; Injections, Intravenous; Kinetics; Middle Aged; Nifedipine; Protein Binding; Verapamil | 1985 |
[Myocardial cellular mechanism of action of calcium antagonists].
Topics: Actin Cytoskeleton; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Heart; Humans; Mitochondria, Heart; Myocardial Contraction; Myocardium; Nifedipine; Sarcolemma; Sarcoplasmic Reticulum; Verapamil | 1985 |
Comparative efficacy of calcium antagonist drugs in the prophylaxis of migraine.
Topics: Calcium Channel Blockers; Cinnarizine; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Flunarizine; Humans; Migraine Disorders; Nicotinic Acids; Nifedipine; Nimodipine; Verapamil | 1985 |
Calcium-channel blockers and systemic hypertension.
Topics: Acute Disease; Angina Pectoris; Animals; Calcium Channel Blockers; Chronic Disease; Diltiazem; Drug Therapy, Combination; Hemodynamics; Humans; Hypercalcemia; Hypertension; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Vasodilation; Verapamil | 1985 |
Calcium channel blocking agents and the heart.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Vasospasm; Digoxin; Diltiazem; Heart Block; Heart Diseases; Heart Rate; Humans; Hypertension; Nifedipine; Verapamil | 1985 |
[Clinical pharmacology of calcium inhibitors].
Topics: Age Factors; Animals; Bepridil; Biological Availability; Biotransformation; Calcium Channel Blockers; Diltiazem; Dogs; Half-Life; Humans; Intestinal Absorption; Kidney Failure, Chronic; Kinetics; Liver Diseases; Metabolic Clearance Rate; Nifedipine; Perhexiline; Protein Binding; Pyrrolidines; Rats; Tissue Distribution; Verapamil | 1985 |
"Calcium antagonists": a class of drugs with a bright future. Part II. Determination of basic pharmacological properties.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Electrophysiology; Heart Rate; Ion Channels; Lanthanum; Methods; Muscle, Smooth; Myocardial Contraction; Nifedipine; Potassium; Pyridines; Receptors, Adrenergic, alpha; Stereoisomerism; Verapamil | 1984 |
Understanding the calcium channel blockers.
Topics: Action Potentials; Angina Pectoris; Animals; Arrhythmias, Cardiac; Arteriosclerosis; Calcium; Calcium Channel Blockers; Calmodulin; Cardiomyopathy, Hypertrophic; Critical Care; Diltiazem; Heart Conduction System; Hemodynamics; Humans; Hypertension; Hypertension, Pulmonary; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nursing Care; Receptors, Adrenergic, beta; Verapamil | 1984 |
Calcium channel blockers as antihypertensive agents.
Topics: Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Diltiazem; Humans; Hypertension; Ion Channels; Nifedipine; Time Factors; Vascular Resistance; Vasodilation; Verapamil | 1984 |
Calcium blocking agents. New directions in the treatment of angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium; Diltiazem; Humans; Ion Channels; Myocardial Contraction; Nifedipine; Oxygen Consumption; Pyridines; Verapamil | 1980 |
Calcium antagonists. Pharmacodynamic effects and mechanism of action.
Topics: Adrenergic beta-Antagonists; Animals; Binding Sites; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Coronary Vessels; Diltiazem; Heart; Humans; Nifedipine; Regional Blood Flow; Terminology as Topic; Verapamil | 1983 |
[Use of calcium antagonists in the therapy of coronary heart disease].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium; Coronary Disease; Diltiazem; Drug Therapy, Combination; Electrocardiography; Humans; Myocardial Contraction; Nifedipine; Nitrates; Oxygen Consumption; Stimulation, Chemical; Tachycardia; Verapamil | 1983 |
Treatment of vasospastic angina.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Anemia; Angina Pectoris, Variant; Atropine; Diltiazem; Drug Therapy, Combination; Epoprostenol; Exercise Therapy; Female; Humans; Hypertension; Hyperthyroidism; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine; Nitroglycerin; Nitroprusside; Nylidrin; Verapamil | 1983 |
Clinical applications of slow channel blocking compounds.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Platelets; Blood Vessels; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Coronary Disease; Coronary Vessels; Diltiazem; Drug Interactions; Electrophysiology; Heart; Heart Failure; Hemodynamics; Humans; Hypertension; Hypertension, Pulmonary; Ischemic Attack, Transient; Nifedipine; Verapamil | 1983 |
Calcium and alpha-adrenoceptors in activation of vascular smooth muscle.
Topics: Animals; Calcium; Diltiazem; Gallopamil; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Verapamil | 1982 |
Clinical pharmacokinetics of calcium channel antagonists.
Topics: Calcium Channel Blockers; Diltiazem; Half-Life; Humans; Kinetics; Nifedipine; Verapamil | 1982 |
Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem.
Topics: Angina Pectoris; Angina Pectoris, Variant; Animals; Arrhythmias, Cardiac; Benzazepines; Calcium; Cardiovascular System; Diltiazem; Dogs; Electrophysiology; Humans; Hypertension; Ion Channels; Kinetics; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Infarction; Nifedipine; Pyridines; Sheep; Tetrodotoxin; Vasodilator Agents; Verapamil | 1980 |
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part I: Basic and clinical electrophysiologic effects.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Clinical Trials as Topic; Cyclic AMP; Diltiazem; Dogs; Electrophysiology; Guinea Pigs; Heart; Heart Conduction System; Humans; Ion Channels; Nifedipine; Pyridines; Sodium; Verapamil | 1980 |
Calcium antagonists and their potential role in the prevention of sudden coronary death.
Topics: Action Potentials; Animals; Atrial Fibrillation; Atrial Flutter; Atrioventricular Node; Calcium Channel Blockers; Cardiac Pacing, Artificial; Coronary Disease; Death, Sudden; Diltiazem; Dogs; Haplorhini; Humans; Ion Channels; Nifedipine; Rabbits; Rats; Tachycardia; Tetrodotoxin; Ventricular Fibrillation; Verapamil; Wolff-Parkinson-White Syndrome | 1982 |
Calcium blocking drugs for angina pectoris.
Topics: Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Humans; Ion Channels; Nifedipine; Vascular Resistance; Verapamil | 1982 |
The hemodynamic effects of calcium channel blocking agents: a brief review.
Topics: Calcium Channel Blockers; Diltiazem; Hemodynamics; Humans; Ion Channels; Muscle Contraction; Nifedipine; Verapamil | 1982 |
Calcium antagonists in the treatment of individuals with ischemic heart disease.
Topics: Angina Pectoris; Angina Pectoris, Variant; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Humans; Ion Channels; Nifedipine; Verapamil | 1982 |
Calcium entry blockers: a review.
Topics: Animals; Calcium; Calcium Channel Blockers; Cricetinae; Diltiazem; Dogs; Heart; Heart Rate; Humans; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Rats; Verapamil | 1982 |
Calcium channel blocking drugs.
Topics: Anesthesia; Angina Pectoris; Animals; Calcium; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Diltiazem; Heart Conduction System; Hemodynamics; Humans; Hypertension; Ion Channels; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Nifedipine; Tachycardia; Verapamil | 1983 |
Calcium antagonists: a new class of drugs.
Topics: Action Potentials; Animals; Binding Sites; Biological Transport; Calcium; Calcium Channel Blockers; Diltiazem; Drug Interactions; Heart Conduction System; Humans; Ion Channels; Muscle, Smooth; Myocardium; Nifedipine; Verapamil | 1983 |
Clinical pharmacology of calcium entry blockers.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Diltiazem; Humans; Ion Channels; Muscle, Smooth, Vascular; Nifedipine; Vasodilator Agents; Verapamil | 1983 |
Calcium antagonists.
Topics: Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Heart; Humans; Ion Channels; Kinetics; Myocardium; Nifedipine; Sodium; Tissue Distribution; Verapamil | 1983 |
Hypertension: calcium-blocking agents in treatment.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Diltiazem; Heart Rate; Humans; Hypertension; Ion Channels; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Verapamil | 1984 |
Calcium antagonists. Mechanisms, therapeutic indications and reservations: a review.
Topics: Animals; Atrioventricular Node; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Drug Interactions; Heart; Humans; Ion Channels; Muscle, Smooth, Vascular; Nifedipine; Verapamil | 1984 |
On the mechanism of action of calcium antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Diltiazem; Guinea Pigs; Ion Channels; Membrane Potentials; Muscle, Smooth; Myocardial Contraction; Nifedipine; Potassium; Rabbits; Rats; Sarcoplasmic Reticulum; Swine; Verapamil | 1984 |
Slow channel blockers.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Constipation; Diltiazem; Dizziness; Dose-Response Relationship, Drug; Heart; Humans; Hypertension; Hypotension; Myocardial Contraction; Nausea; Nifedipine; Verapamil | 1983 |
[Calcium antagonists in cardiology].
Topics: Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Coronary Disease; Diltiazem; Heart Diseases; Humans; Hypertension; Nifedipine; Verapamil | 1983 |
Calcium antagonists. Pharmacokinetic properties.
Topics: Administration, Oral; Aging; Biological Availability; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Diltiazem; Drug Interactions; Humans; Injections, Intravenous; Kinetics; Nifedipine; Protein Binding; Tissue Distribution; Verapamil | 1983 |
Calcium antagonists. Clinical use in the treatment of systemic hypertension.
Topics: Angina Pectoris; Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Nifedipine; Verapamil | 1983 |
Adverse reactions to calcium antagonists.
Topics: Calcium Channel Blockers; Diltiazem; Drug Interactions; Humans; Kinetics; Lidoflazine; Nifedipine; Perhexiline; Prenylamine; Risk; Verapamil | 1983 |
[The role of calcium antagonists in the treatment of classical angina pectoris].
Topics: Angina Pectoris; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Exercise Test; Humans; Nifedipine; Random Allocation; Verapamil | 1983 |
Calcium entry blockers: potential applications in shock.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Disease; Diltiazem; Dogs; Myocardial Contraction; Nifedipine; Shock; Shock, Hemorrhagic; Syndrome; Verapamil | 1983 |
[Anti-arrhythmic therapy with calcium antagonists].
Topics: Arrhythmias, Cardiac; Benzazepines; Bradycardia; Calcium Channel Blockers; Digitalis Glycosides; Diltiazem; Drug Therapy, Combination; Heart Arrest; Heart Rate; Humans; Male; Middle Aged; Tachycardia, Paroxysmal; Verapamil; Wolff-Parkinson-White Syndrome | 1983 |
[Calcium antagonists in the therapy of hypertension].
Topics: Biological Transport; Blood Pressure; Calcium; Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Kidney; Nifedipine; Time Factors; Verapamil | 1983 |
Value and limitations of provocative testing to assess the efficacy of treatment in variant angina.
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Cold Temperature; Diltiazem; Electrocardiography; Ergonovine; Exercise Test; Humans; Hyperventilation; Nifedipine; Phentolamine; Propranolol; Verapamil | 1983 |
Calcium-channel blockers in vasospastic angina--a review.
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Ergonovine; Humans; Nifedipine; Verapamil | 1983 |
[Use of calcium antagonists in the treatment of cardiac insufficiency].
Topics: Adult; Aged; Calcium Channel Blockers; Diltiazem; Heart Failure; Humans; Middle Aged; Nifedipine; Verapamil | 1984 |
Use of calcium channel blocking agents in angina pectoris.
Topics: Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Humans; Kinetics; Nifedipine; Verapamil | 1984 |
Cellular action of calcium channel blocking drugs.
Topics: Binding Sites; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry; Coronary Vessels; Diltiazem; Hemodynamics; Muscle Contraction; Nifedipine; Radioligand Assay; Regional Blood Flow; Structure-Activity Relationship; Verapamil | 1984 |
Calcium-channel blocking agents: current indications and potential uses.
Topics: Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Drug Interactions; Humans; Nifedipine; Verapamil | 1984 |
[Calcium antagonists. Properties and current indications].
Topics: Arrhythmias, Cardiac; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Drug Interactions; Female; Humans; Male; Nifedipine; Verapamil | 1984 |
Calcium channel blockers in emergency medicine.
Topics: Action Potentials; Animals; Benzazepines; Calcium; Diltiazem; Emergencies; Heart Diseases; Humans; Nifedipine; Verapamil | 1984 |
Treatment of hypertension with calcium channel blockers: European data.
Topics: Age Factors; Blood Pressure; Calcium Channel Blockers; Coronary Disease; Diltiazem; Europe; Humans; Hypertension; Japan; Nifedipine; Physical Exertion; Renin-Angiotensin System; Sympathetic Nervous System; Time Factors; Vasodilation; Verapamil; Water-Electrolyte Balance | 1984 |
Calcium-channel blockers and the gastrointestinal tract. American College of Gastroenterology's Committee on FDA related matters.
Topics: Animals; Calcium Channel Blockers; Digestive System; Diltiazem; Esophageal Achalasia; Esophageal Diseases; Esophagogastric Junction; Esophagus; Gastric Acid; Gastrointestinal Motility; Humans; Intestines; Liver; Nifedipine; Pancreas; Pressure; Stomach; Verapamil | 1984 |
Clinical differentiation of nifedipine and other calcium antagonists.
Topics: Biological Availability; Calcium Channel Blockers; Diltiazem; Drug Tolerance; Heart Diseases; Hemodynamics; Humans; Kinetics; Nifedipine; Perhexiline; Verapamil | 1984 |
New antiarrhythmic drugs.
Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil | 1983 |
The clinical uses of calcium antagonists.
Topics: Angina Pectoris; Angina Pectoris, Variant; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Cardiomegaly; Diltiazem; Dogs; Humans; Myocardial Contraction; Nifedipine; Tachycardia; Verapamil | 1982 |
Calcium antagonists in the treatment of hypertension.
Topics: Blood Pressure; Calcium; Calcium Channel Blockers; Diltiazem; Heart Rate; Humans; Hypertension; Nifedipine; Vascular Resistance; Verapamil | 1982 |
Hemodynamic and clinical effects of combined verapamil and propranolol therapy in angina pectoris.
Topics: Angina Pectoris; Animals; Blood Pressure; Clinical Trials as Topic; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Exercise Test; Hemodynamics; Humans; Nifedipine; Propranolol; Stroke Volume; Verapamil | 1982 |
[Treatment of angina pectoris with calcium antagonists].
Topics: Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Therapy, Combination; Exercise Test; Fendiline; Humans; Nicardipine; Nifedipine; Perhexiline; Prenylamine; Propafenone; Propiophenones; Verapamil | 1982 |
[Treatment of coronary arterial spasm].
Topics: Amiodarone; Coronary Vasospasm; Denervation; Diltiazem; Humans; Isosorbide Dinitrate; Myocardial Revascularization; Nifedipine; Nitroglycerin; Phenoxybenzamine; Phentolamine; Reserpine; Verapamil | 1982 |
Calcium antagonists.
Topics: Action Potentials; Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Bronchial Spasm; Calcium; Diazoxide; Diltiazem; Hemodynamics; Humans; Hydralazine; Lanthanum; Muscle, Smooth; Myocardial Contraction; Nifedipine; Nitrites; Nitroprusside; Papillary Muscles; Verapamil | 1980 |
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications.
Topics: Benzazepines; Calcium Channel Blockers; Cardiovascular Diseases; Coronary Circulation; Diltiazem; Hemodynamics; Humans; Myocardial Contraction; Nifedipine; Nitrogen; Perhexiline; Piperidines; Pyridines; Regional Blood Flow; Vasodilation; Verapamil | 1980 |
Are calcium-channel blockers effective in the treatment of tardive dyskinesia?
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Dyskinesia, Drug-Induced; Humans; Nifedipine; Palliative Care; Verapamil | 1993 |
Poisoning with anti-hypertensive drugs: calcium antagonists.
Topics: Age Factors; Antihypertensive Agents; Calcium; Diltiazem; Drug Overdose; Humans; Hypertension; Nifedipine; Risk Factors; Verapamil | 1995 |
Do calcium channel blockers have renal protective effects?
Topics: Aging; Animals; Calcium Channel Blockers; Clinical Trials as Topic; Cyclosporine; Diabetic Nephropathies; Dihydropyridines; Diltiazem; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension, Renal; Kidney; Kidney Transplantation; Rats; Rats, Inbred SHR; Verapamil | 1994 |
Management of rapid ventricular rate in acute atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Heart Rate; Humans; Propranolol; Verapamil; Wolff-Parkinson-White Syndrome | 1994 |
Calcium channel blockers in heart failure.
Topics: Calcium Channel Blockers; Diltiazem; Heart Failure; Hemodynamics; Humans; Nifedipine; Verapamil | 1993 |
Similarities and differences between calcium antagonists: pharmacological aspects.
Topics: Angina Pectoris; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Humans; Hypertension; Nifedipine; Vasodilator Agents; Verapamil | 1993 |
Management of atrial fibrillation in adults: prevention of thromboembolism and symptomatic treatment.
Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Catheter Ablation; Cerebrovascular Disorders; Diabetes Complications; Digoxin; Diltiazem; Embolism; Humans; Hypertension; Thromboembolism; Verapamil; Warfarin | 1996 |
[Control of heart rate and atrial fibrillation].
Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Chronic Disease; Digitalis Glycosides; Diltiazem; Heart Rate; Humans; Verapamil | 1996 |
The effects of calcium antagonists after PTCA.
Topics: Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Clinical Trials as Topic; Constriction, Pathologic; Coronary Disease; Diltiazem; Humans; Nifedipine; Recurrence; Verapamil | 1995 |
Re-examining the clinical safety and roles of calcium antagonists in cardiovascular medicine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiovascular Diseases; Coronary Vessels; Diltiazem; Humans; Myocardial Infarction; Myocardial Ischemia; Ventricular Dysfunction; Verapamil | 1996 |
Calcium antagonists and cardiovascular prognosis: a homogeneous group?
Topics: Calcium Channel Blockers; Cardiovascular Diseases; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Humans; Prognosis; Verapamil | 1996 |
Identification of binding sites for calcium channel antagonists.
Topics: Affinity Labels; Benzazepines; Binding Sites; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Drug Interactions; Humans; Muscle, Skeletal; Thiazepines; Verapamil | 1996 |
Bioequivalence of controlled-release calcium antagonists.
Topics: Calcium Channel Blockers; Clinical Trials as Topic; Delayed-Action Preparations; Diltiazem; Drugs, Generic; Humans; Isradipine; Therapeutic Equivalency; United States; United States Food and Drug Administration; Verapamil | 1997 |
[Calcium channel blockers in heart failure].
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Heart Failure; Humans; Ventricular Dysfunction, Left; Verapamil | 1997 |
Calcium channel blockers: an evidence-based review.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Verapamil | 1997 |
Safety of heart rate-lowering calcium antagonists: lessons from controlled trials.
Topics: Calcium Channel Blockers; Controlled Clinical Trials as Topic; Diltiazem; Humans; Meta-Analysis as Topic; Myocardial Infarction; Recurrence; Verapamil | 1997 |
Calcium channel blockers in left ventricular dysfunction or congestive heart failure.
Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Felodipine; Heart Failure; Humans; Nicardipine; Nifedipine; Ventricular Dysfunction, Left; Verapamil | 1997 |
[Verapamil and diltiazem in the treatment of atrial fibrillation].
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Contraindications; Diltiazem; Humans; Verapamil | 1997 |
Diversity of calcium antagonists.
Topics: Angina Pectoris; Arteriosclerosis; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Kidney Failure, Chronic; Mibefradil; Nifedipine; Tetrahydronaphthalenes; Verapamil | 1997 |
Use of calcium channel blockers in hypertension.
Topics: Antihypertensive Agents; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Heart Diseases; Humans; Hypertension; Longitudinal Studies; Mibefradil; Nifedipine; Public Health; Randomized Controlled Trials as Topic; Risk Factors; Tetrahydronaphthalenes; Vasodilator Agents; Verapamil | 1998 |
Comparative pharmacological properties among calcium channel blockers: T-channel versus L-channel blockade.
Topics: Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Electrocardiography; Hemodynamics; Humans; Mibefradil; Tetrahydronaphthalenes; Verapamil | 1998 |
Recalcitrant oral ulcers caused by calcium channel blockers: diagnosis and treatment considerations.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Diltiazem; Female; Humans; Male; Oral Ulcer; Recurrence; Treatment Failure; Verapamil | 1999 |
The evidence regarding the drugs used for ventricular rate control.
Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Bias; Calcium Channel Blockers; Digoxin; Diltiazem; Evidence-Based Medicine; Exercise; Heart Rate; Humans; Research Design; Rest; Treatment Outcome; Ventricular Function; Verapamil | 2000 |
Diltiazem, nifedipine, nimodipine or verapamil for neuroleptic-induced tardive dyskinesia.
Topics: Antipsychotic Agents; Calcium Channel Blockers; Diltiazem; Dyskinesia, Drug-Induced; Humans; Nifedipine; Nimodipine; Verapamil | 2000 |
Do we need hypothermia in myocardial protection?
Topics: Animals; Cardiac Surgical Procedures; Cardioplegic Solutions; Diltiazem; Heart Arrest, Induced; Humans; Hypothermia, Induced; Myocardium; Oxygen Consumption; Temperature; Verapamil | 2000 |
Calcium channel antagonists for the treatment of bipolar disorder.
Topics: Antimanic Agents; Bipolar Disorder; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Humans; Lithium Compounds; Nifedipine; Nimodipine; Randomized Controlled Trials as Topic; Verapamil | 2000 |
Heart rate-lowering calcium antagonists in hypertensive post-myocardial infarction patients.
Topics: Aged; Calcium Channel Blockers; Diltiazem; Female; Heart Rate; Humans; Hypertension; Lung Diseases; Male; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Randomized Controlled Trials as Topic; Verapamil | 2001 |
Chronopharmacology of cardiovascular therapy.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Cardiovascular Agents; Catecholamines; Chronotherapy; Circadian Rhythm; Clinical Trials as Topic; Cross-Over Studies; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Electrocardiography, Ambulatory; Hemodynamics; Humans; Middle Aged; Multicenter Studies as Topic; Myocardial Infarction; Myocardial Ischemia; Sleep; Stroke; Verapamil | 2002 |
Acute atrial fibrillation.
Topics: Acute Disease; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Electrocardiography; Fibrinolytic Agents; Humans; Prognosis; Randomized Controlled Trials as Topic; Thromboembolism; Timolol; Treatment Outcome; Verapamil | 2002 |
Pharmacological rate control of atrial fibrillation.
Topics: Amiodarone; Atenolol; Atrial Fibrillation; Cardiotonic Agents; Digoxin; Diltiazem; Heart Rate; Humans; Metoprolol; Randomized Controlled Trials as Topic; Verapamil | 2004 |
New advances in the field of calcium channel antagonists: cardiovascular effects and structure-activity relationships.
Topics: Angina Pectoris; Animals; Calcium Channel Blockers; Calcium Channels; Cardiovascular System; Diltiazem; Humans; Hypertension; Nifedipine; Structure-Activity Relationship; Verapamil | 2003 |
Atrial fibrillation (acute).
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Humans; Timolol; Verapamil | 2003 |
Atrial fibrillation (acute).
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Timolol; Verapamil | 2003 |
Atrial fibrillation (acute).
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil | 2004 |
Calcium channel blockers and the kidney.
Topics: Black or African American; Calcium Channel Blockers; Diabetic Nephropathies; Dihydropyridines; Diltiazem; Humans; Hypertension; Kidney; Kidney Failure, Chronic; United States; Verapamil | 2004 |
Atrial fibrillation (recent onset).
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil | 2005 |
[Indications for calcium channel antagonist therapy according to the latest large clinical trials].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Antihypertensive Agents; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Female; Humans; Hypertension; Male; Meta-Analysis as Topic; Myocardial Ischemia; Nifedipine; Randomized Controlled Trials as Topic; Treatment Outcome; Verapamil | 2005 |
Calcium antagonists for Duchenne muscular dystrophy.
Topics: Calcium Channel Blockers; Diltiazem; Flunarizine; Humans; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Nifedipine; Randomized Controlled Trials as Topic; Verapamil | 2008 |
Supraventricular tachycardia.
Topics: Adenosine; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Cardiovascular Agents; Diltiazem; Electrocardiography; Electrocardiography, Ambulatory; Heart Conduction System; Humans; Pre-Excitation Syndromes; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular; Verapamil | 2009 |
The no-reflow phenomenon in the coronary circulation.
Topics: Adenosine; Animals; Coronary Circulation; Diltiazem; Humans; Nicardipine; Nicorandil; Nitroprusside; No-Reflow Phenomenon; Prostheses and Implants; Vasodilator Agents; Verapamil | 2009 |
Subendocardial ischemia in hypertrophic cardiomyopathy.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cardiomyopathy, Hypertrophic; Diagnostic Imaging; Diltiazem; Echocardiography; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Ischemia; Positron-Emission Tomography; Prognosis; Prospective Studies; Pyrimidinones; Tomography, Emission-Computed, Single-Photon; Verapamil | 2014 |
Short-Term Effects of Verapamil and Diltiazem in the Treatment of No Reflow Phenomenon: A Meta-Analysis of Randomized Controlled Trials.
Topics: Calcium Channel Blockers; Cardiovascular Agents; Diltiazem; Humans; No-Reflow Phenomenon; Randomized Controlled Trials as Topic; Verapamil | 2015 |
[Use of Verapamil and Dilthiasem in treating patients at high cardiovascular risk (review of literature)].
Topics: Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Humans; Verapamil | 2016 |
Diagnosis and management of supraventricular tachycardias.
Topics: Adenosine; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Calcium Channel Blockers; Catheter Ablation; Diltiazem; Disease Management; Electric Countershock; Electrocardiography; Humans; Practice Guidelines as Topic; Tachycardia, Supraventricular; Verapamil | 2016 |
Alternative Treatment Options for Atrioventricular-Nodal-Reentry Tachycardia: An Emergency Medicine Review.
Topics: Adenosine; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Calcium Channel Blockers; Diltiazem; Electric Countershock; Electrocardiography; Emergency Medicine; Emergency Service, Hospital; Female; Humans; Male; Metoprolol; Propanolamines; Propranolol; Review Literature as Topic; Tachycardia, Atrioventricular Nodal Reentry; Vagus Nerve Stimulation; Verapamil | 2018 |
118 trial(s) available for diltiazem and verapamil
| Article | Year |
|---|---|
Comparison of verapamil and diltiazem in the suppression of idiopathic ventricular tachycardia.
Topics: Adult; Bundle-Branch Block; Cardiac Pacing, Artificial; Diltiazem; Exercise Test; Female; Heart Conduction System; Humans; Male; Tachycardia, Ventricular; Verapamil | 1992 |
Calcium antagonists in the treatment early after myocardial infarction. The DEFIANT Research Group.
Topics: Adult; Aged; Calcium Channel Blockers; Denmark; Diltiazem; Echocardiography, Doppler; Humans; Middle Aged; Myocardial Contraction; Myocardial Infarction; Random Allocation; Ventricular Function, Left; Verapamil | 1992 |
Secondary prevention with calcium antagonists after acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Diltiazem; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nifedipine; Random Allocation; Recurrence; Verapamil | 1992 |
[Calcium channel blockers and prevention of migraine].
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Diltiazem; Flunarizine; Humans; Migraine Disorders; Nifedipine; Nimodipine; Verapamil | 1992 |
[Thrombocyte aggregation and serum thromboxane B2 in patients with unstable angina pectoris treated with diltiazem or verapamil].
Topics: Angina, Unstable; Diltiazem; Drug Evaluation; Female; Humans; Male; Middle Aged; Pilot Projects; Platelet Aggregation; Platelet Aggregation Inhibitors; Thromboxane B2; Verapamil | 1992 |
Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine.
Topics: Administration, Oral; Adolescent; Adult; Antidepressive Agents, Tricyclic; Biological Availability; Desipramine; Diltiazem; Drug Administration Schedule; Drug Interactions; Humans; Imipramine; Labetalol; Male; Verapamil | 1992 |
The effects of nisoldipine, diltiazem, nifedipine, and verapamil on hemodynamic parameters and red blood cells-platelet interactions in patients with arterial hypertension.
Topics: Adult; Aged; Arteries; Blood Platelets; Blood Pressure; Calcium Channel Blockers; Diltiazem; Erythrocytes; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nisoldipine; Verapamil | 1991 |
Prevention of restenosis after PTCA: role of calcium antagonists.
Topics: Aged; Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Coronary Disease; Diltiazem; Double-Blind Method; Female; Humans; Male; Middle Aged; Nifedipine; Recurrence; Risk Factors; Verapamil | 1991 |
Calcium-antagonists in preventing restenosis following coronary angioplasty.
Topics: Angioplasty, Balloon, Coronary; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Humans; Nifedipine; Recurrence; Verapamil | 1991 |
Effects of verapamil and diltiazem on gastric emptying in normal subjects.
Topics: Adult; Diltiazem; Gastric Emptying; Humans; Male; Radionuclide Imaging; Stomach; Technetium Tc 99m Sulfur Colloid; Time Factors; Verapamil | 1991 |
[Comparison of the efficacy of verapamil and diltiazem in stable exercise angina. A double-blind and crossover study].
Topics: Aged; Angina Pectoris; Clinical Trials as Topic; Coronary Angiography; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Humans; Male; Middle Aged; Verapamil | 1990 |
[Evaluation of the effects of verapamil, flunarizine, diltiazem, nimodipine and placebo in the prevention of hemicrania. A double-blind randomized cross-over study].
Topics: Adolescent; Adult; Diltiazem; Double-Blind Method; Female; Flunarizine; Humans; Male; Middle Aged; Migraine Disorders; Nimodipine; Placebos; Verapamil | 1990 |
An exercise hemodynamic comparison of verapamil, diltiazem, and amlodipine in coronary artery disease.
Topics: Amlodipine; Angina Pectoris; Calcium Channel Blockers; Cardiac Output; Coronary Disease; Diltiazem; Exercise; Hemodynamics; Humans; Middle Aged; Nifedipine; Prospective Studies; Rest; Verapamil | 1990 |
Effects of calcium channel blockers on platelet aggregation and thromboxane A2 formation: an in vivo double blind randomized study.
Topics: Adult; Blood Platelets; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Female; Humans; Male; Middle Aged; Nifedipine; Platelet Aggregation; Thromboxane A2; Verapamil | 1990 |
Retardation of development and progression of coronary atherosclerosis: a new indication for calcium antagonists?
Topics: Animals; Coronary Artery Bypass; Coronary Artery Disease; Diet, Atherogenic; Diltiazem; Female; Humans; Male; Nicardipine; Prospective Studies; Rabbits; Retrospective Studies; Time Factors; Verapamil | 1990 |
[The results of a clinical study of the preparation kardil].
Topics: Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Humans; Hypertension; Nifedipine; USSR; Verapamil | 1990 |
Ventricular rate control and exercise performance in chronic atrial fibrillation: effects of diltiazem and verapamil.
Topics: Aged; Anaerobic Threshold; Atrial Fibrillation; Diltiazem; Electrocardiography, Ambulatory; Female; Hemodynamics; Humans; Male; Middle Aged; Oxygen Consumption; Physical Exertion; Pulmonary Gas Exchange; Verapamil | 1990 |
A double-blind, randomized, crossover comparison of equivalent (by weight) oral doses of verapamil and diltiazem in patients with mild to moderate hypertension.
Topics: Blood Pressure; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Heart Rate; Humans; Hypertension; Random Allocation; Verapamil | 1989 |
Calcium channel blockers. Potential medical benefits and side effects.
Topics: Blood Pressure; Calcium Channel Blockers; Diltiazem; Exercise; Humans; Hypertension; Nifedipine; United States; Verapamil | 1989 |
Comparison of the antianginal efficacy of four calcium antagonists and propranolol in stable angina pectoris.
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Exercise Test; Female; Humans; Male; Nicardipine; Nifedipine; Nitroglycerin; Propranolol; Single-Blind Method; Verapamil | 1989 |
Comparative evaluation of the effects of labetalol, verapamil and diltiazem on antipyrine and indocyanine green clearances.
Topics: Adult; Antipyrine; Diltiazem; Half-Life; Humans; Indocyanine Green; Labetalol; Male; Random Allocation; Verapamil | 1989 |
The effects of verapamil, diltiazem, nifedipine and propranolol on metabolic control in hypertensives with non-insulin dependent diabetes mellitus.
Topics: Aged; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Mellitus, Type 2; Diltiazem; Female; Fructosamine; Glycated Hemoglobin; Heart Rate; Hexosamines; Humans; Hypertension; Insulin; Male; Middle Aged; Nifedipine; Propranolol; Triglycerides; Verapamil | 1989 |
Review of calcium antagonist trials in acute myocardial infarction.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Randomized Controlled Trials as Topic; Verapamil | 1989 |
[Cross-over double-blind study of verapamil versus diltiazem in effort myocardial ischemia].
Topics: Coronary Disease; Diltiazem; Double-Blind Method; Female; Humans; Male; Middle Aged; Physical Exertion; Random Allocation; Verapamil | 1989 |
Combination therapy with calcium-channel blockers and beta blockers for chronic stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Animals; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electrophysiology; Hemodynamics; Humans; Male; Nifedipine; Verapamil | 1985 |
Antihypertensive therapy with calcium-channel blockers: comparison with beta blockers.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Drug Therapy, Combination; Europe; Heart Rate; Humans; Hypertension; Nifedipine; United States; Verapamil | 1985 |
Relationships between heart rate and PR interval during physiological and pharmacological interventions.
Topics: Adrenergic beta-Antagonists; Adult; Atrioventricular Node; Diltiazem; Electrocardiography; Female; Heart Rate; Humans; Isoproterenol; Male; Nifedipine; Physical Exertion; Receptors, Adrenergic, beta; Verapamil | 1987 |
Comparative effects of calcium entry-blocking drugs, beta-blocking drugs, and their combination in patients with chronic stable angina.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Exercise Test; Female; Heart Ventricles; Humans; Male; Middle Aged; Nifedipine; Propranolol; Radionuclide Imaging; Verapamil | 1987 |
Comparative hemodynamic dose-response effects of five slow calcium channel-blocking agents in coronary artery disease.
Topics: Amlodipine; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Male; Middle Aged; Nicardipine; Nifedipine; Nisoldipine; Prospective Studies; Random Allocation; Verapamil | 1987 |
Effects of verapamil and diltiazem on human platelet function.
Topics: Benzazepines; Blood Platelets; Calcium; Cytoplasmic Granules; Diltiazem; Epinephrine; Humans; Platelet Aggregation; Platelet Function Tests; Receptors, Adrenergic, alpha; Serotonin; Thromboxane B2; Verapamil | 1986 |
Effects of nifedipine, verapamil and diltiazem on renal function.
Topics: Adult; Diltiazem; Diuresis; Female; Glomerular Filtration Rate; Humans; Kidney; Natriuresis; Nifedipine; Potassium; Renin; Sodium; Verapamil | 1988 |
Factors affecting the clinical response to treatment with digoxin and two calcium antagonists in patients with atrial fibrillation.
Topics: Atrial Fibrillation; Calcium Channel Blockers; Clinical Trials as Topic; Digoxin; Diltiazem; Double-Blind Method; Heart Rate; Humans; Physical Exertion; Random Allocation; Rheumatic Heart Disease; Verapamil | 1988 |
[Comparative study of the effect of 3 calcium antagonists in chronic stable angina].
Topics: Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Random Allocation; Verapamil | 1988 |
Effectiveness of calcium antagonist drugs in patients with unstable angina and proven coronary artery disease.
Topics: Adult; Aged; Angina Pectoris; Angina, Unstable; Calcium; Coronary Disease; Diltiazem; Electrocardiography; Female; Heparin; Humans; Infusions, Intravenous; Male; Middle Aged; Monitoring, Physiologic; Nitroglycerin; Verapamil | 1988 |
Comparative effects of prolonged therapy with four calcium ion antagonists (diltiazem, nicardipine, tiapamil and verapamil) in patients with chronic stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Diltiazem; Female; Humans; Male; Middle Aged; Nicardipine; Propylamines; Tiapamil Hydrochloride; Verapamil | 1987 |
Relationships between heart rate, exercise tolerance and cardiac output in atrial fibrillation: the effects of treatment with digoxin, verapamil and diltiazem.
Topics: Aged; Atrial Fibrillation; Cardiac Output; Chronic Disease; Digoxin; Diltiazem; Heart Rate; Humans; Middle Aged; Physical Exertion; Verapamil | 1988 |
Comparison of equal-weight oral dosages of verapamil hydrochloride and diltiazem hydrochloride in patients with mild to moderate hypertension.
Topics: Aged; Aged, 80 and over; Blood Pressure; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Electrocardiography; Female; Humans; Hypertension; Male; Middle Aged; Random Allocation; Verapamil | 1988 |
[Comparative evaluation of 3 calcium antagonist drugs in patients with stable angina of effort. Double-blind placebo-controlled randomized study].
Topics: Adult; Aged; Angina Pectoris; Clinical Trials as Topic; Diltiazem; Exercise Test; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1987 |
Adrenaline-induced changes in serum electrolytes, ECG, and blood pressure, with Ca-blockade pretreatment.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Diltiazem; Electrocardiography; Electrolytes; Epinephrine; Heart; Humans; Male; Premedication; Stress, Physiological; Verapamil | 1988 |
Effect of calcium channel blockers on theophylline disposition.
Topics: Adult; Calcium Channel Blockers; Data Interpretation, Statistical; Diltiazem; Half-Life; Humans; Male; Nifedipine; Random Allocation; Theophylline; Verapamil | 1988 |
The role of calcium channel blockers in the treatment of hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Follow-Up Studies; Heart Rate; Hemodynamics; Humans; Hypertension; Kidney; Kinetics; Labetalol; Nifedipine; Sympathetic Nervous System; Verapamil | 1986 |
Calcium-channel blockers for combined angina pectoris and systemic hypertension.
Topics: Adult; Aged; Angina Pectoris; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Diltiazem; Double-Blind Method; Heart; Heart Rate; Humans; Hypertension; Middle Aged; Myocardium; Nifedipine; Oxygen Consumption; Physical Exertion; Propranolol; Random Allocation; Risk; Verapamil | 1986 |
Current status of calcium channel blocking drugs after myocardial infarction.
Topics: Calcium Channel Blockers; Canada; Clinical Trials as Topic; Denmark; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Norway; Time Factors; United States; Verapamil | 1986 |
Comparable effects of oral diltiazem and verapamil in the treatment of hypertrophic cardiomyopathy. Double-blind crossover study.
Topics: Administration, Oral; Adult; Blood Pressure; Cardiomyopathy, Hypertrophic; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Echocardiography; Electrocardiography; Exercise Test; Female; Heart; Heart Rate; Humans; Male; Verapamil | 1986 |
Secondary prevention with calcium channel-blocking drugs in patients after myocardial infarction: a critical review.
Topics: Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Recurrence; Verapamil | 1987 |
Calcium-channel blockers for combined systemic hypertension and myocardial ischemia.
Topics: Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Diltiazem; Double-Blind Method; Hemodynamics; Humans; Hypertension; Nifedipine; Random Allocation; Time Factors; Verapamil | 1987 |
[Comparative evaluation using an ergometric test of the efficacy of the 3 major calcium antagonists on exertion stable angina].
Topics: Adult; Angina Pectoris; Blood Pressure; Diltiazem; Double-Blind Method; Female; Heart Rate; Humans; Male; Middle Aged; Nifedipine; Physical Exertion; Random Allocation; Verapamil | 1987 |
Changes in antipyrine and indocyanine green kinetics during nifedipine, verapamil, and diltiazem therapy.
Topics: Adult; Antipyrine; Benzazepines; Biological Availability; Diltiazem; Drug Interactions; Female; Humans; Indocyanine Green; Kinetics; Liver; Male; Metabolic Clearance Rate; Nifedipine; Random Allocation; Verapamil | 1986 |
Effect of acute calcium slow-channel antagonism on the cardiorespiratory response to graded exercise testing.
Topics: Adult; Calcium Channel Blockers; Diltiazem; Exercise Test; Heart Rate; Humans; Male; Nifedipine; Oxygen Consumption; Pulmonary Gas Exchange; Respiratory Function Tests; Verapamil | 1986 |
[Diltiazem in spontaneous angina: comparison with nifedipine and verapamil].
Topics: Adult; Aged; Angina Pectoris; Benzazepines; Diltiazem; Drug Evaluation; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Monitoring, Physiologic; Nifedipine; Research Design; Verapamil | 1985 |
Raynaud's phenomenon: pathophysiologic features and treatment with calcium-channel blockers.
Topics: Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Female; Humans; Male; Nifedipine; Prospective Studies; Random Allocation; Raynaud Disease; Verapamil | 1985 |
Calcium-channel blocking agents for gastrointestinal disorders.
Topics: Animals; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Esophageal Achalasia; Esophagus; Gastrointestinal Diseases; Humans; Muscle, Smooth; Nifedipine; Opossums; Papio; Peristalsis; Verapamil | 1985 |
Clinical and hemodynamic evaluation of propranolol in combination with verapamil, nifedipine and diltiazem in exertional angina pectoris: a placebo-controlled, double-blind, randomized, crossover study.
Topics: Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Placebos; Propranolol; Random Allocation; Verapamil | 1985 |
Diltiazem, verapamil, and quinidine in patients with chronic atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Benzazepines; Chronic Disease; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Female; Humans; Male; Middle Aged; Quinidine; Random Allocation; Verapamil | 1985 |
Are calcium antagonists cardioprotective?
Topics: Angina Pectoris; Animals; Blood Viscosity; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Circulation; Coronary Disease; Diltiazem; Heart; Humans; Hypertension; Myocardial Contraction; Myocardial Infarction; Nifedipine; Platelet Aggregation; Verapamil | 1985 |
Effects of verapamil, diltiazem, and nifedipine on plasma levels and renal excretion of digitoxin.
Topics: Aged; Benzazepines; Clinical Trials as Topic; Digitoxin; Diltiazem; Drug Interactions; Drug Therapy, Combination; Female; Heart Diseases; Humans; Kidney; Kidney Diseases; Kinetics; Liver Diseases; Male; Middle Aged; Nifedipine; Radioimmunoassay; Verapamil | 1985 |
Comparative efficacy of calcium antagonist drugs in the prophylaxis of migraine.
Topics: Calcium Channel Blockers; Cinnarizine; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Flunarizine; Humans; Migraine Disorders; Nicotinic Acids; Nifedipine; Nimodipine; Verapamil | 1985 |
[Verapamil, diltiazem or nifedipine in severe left ventricular functional disorder? A comparative study of the immediate hemodynamic effects].
Topics: Adult; Calcium Channel Blockers; Cardiac Volume; Cardiomyopathy, Dilated; Diltiazem; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Pulmonary Wedge Pressure; Stroke Volume; Verapamil | 1986 |
[Differential therapy with calcium antagonists. Hemodynamic studies using nifedipine, verapamil and diltiazem].
Topics: Calcium Channel Blockers; Coronary Disease; Diltiazem; Exercise Test; Heart Rate; Hemodynamics; Humans; Middle Aged; Nifedipine; Pulmonary Wedge Pressure; Stroke Volume; Verapamil | 1985 |
Calcium channel blockers as antihypertensive agents.
Topics: Blood Pressure; Calcium Channel Blockers; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Diltiazem; Humans; Hypertension; Ion Channels; Nifedipine; Time Factors; Vascular Resistance; Vasodilation; Verapamil | 1984 |
Calcium antagonists, firstline partners for betablockers in hypertension.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Hemodynamics; Humans; Hypertension; Nifedipine; Nitrendipine; Renin; Verapamil | 1984 |
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part I: Basic and clinical electrophysiologic effects.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Clinical Trials as Topic; Cyclic AMP; Diltiazem; Dogs; Electrophysiology; Guinea Pigs; Heart; Heart Conduction System; Humans; Ion Channels; Nifedipine; Pyridines; Sodium; Verapamil | 1980 |
Calcium channel blocking agents.
Topics: Benzazepines; Calcium; Calcium Channel Blockers; Cardiomegaly; Clinical Trials as Topic; Coronary Disease; Diltiazem; Hemodynamics; Humans; Hypertension; Ion Channels; Nifedipine; Pyridines; Systole; Verapamil | 1981 |
Long-term efficacy of diltiazem for control of symptoms of coronary artery spasm.
Topics: Adult; Benzazepines; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Vasospasm; Diltiazem; Female; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1983 |
The pharmacology of calcium channel antagonists: a novel class of anti-migraine agents?
Topics: Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Cyproheptadine; Diltiazem; Humans; Migraine Disorders; Muscle, Smooth, Vascular; Nicotinic Acids; Nifedipine; Nimodipine; Vasomotor System; Verapamil | 1983 |
Calcium-channel blockers in vasospastic angina--a review.
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Ergonovine; Humans; Nifedipine; Verapamil | 1983 |
Clinical outcome after treatment of rest angina with calcium blockers: comparative experience during the initial year of therapy with diltiazem, nifedipine, and verapamil.
Topics: Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Female; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1983 |
Use of calcium channel blocking agents in angina pectoris.
Topics: Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Humans; Kinetics; Nifedipine; Verapamil | 1984 |
[Calcium antagonists. Properties and current indications].
Topics: Arrhythmias, Cardiac; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Drug Interactions; Female; Humans; Male; Nifedipine; Verapamil | 1984 |
The efficacy and safety of high-dose verapamil and diltiazem in the long-term treatment of stable exertional angina.
Topics: Angina Pectoris; Benzazepines; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Hemodynamics; Humans; Male; Middle Aged; Physical Exertion; Random Allocation; Time Factors; Verapamil | 1984 |
[Objective evaluation of calcium antagonists in Prinzmetal's angina with the ergonovine test].
Topics: Adult; Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Vasospasm; Diltiazem; Electrocardiography; Ergonovine; Female; Humans; Male; Middle Aged; Nifedipine; Prognosis; Verapamil | 1983 |
Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients.
Topics: Administration, Oral; Adult; Aged; Aging; Diltiazem; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Nifedipine; Uremia; Verapamil | 1984 |
Effect of calcium antagonists on cardiac performance in patients with dilatative cardiomyopathy evaluated by noninvasive methods.
Topics: Adult; Calcium; Calcium Channel Blockers; Cardiomyopathies; Diltiazem; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Heart; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Radionuclide Imaging; Random Allocation; Vasodilator Agents; Verapamil | 1983 |
Hemodynamic and clinical effects of combined verapamil and propranolol therapy in angina pectoris.
Topics: Angina Pectoris; Animals; Blood Pressure; Clinical Trials as Topic; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Exercise Test; Hemodynamics; Humans; Nifedipine; Propranolol; Stroke Volume; Verapamil | 1982 |
[Calcium antagonists in the treatment of arterial hypertension].
Topics: Benzazepines; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Humans; Hypertension; Nifedipine; Pyridines; Verapamil | 1982 |
[Ergometrine test in the evaluation of drugs for spastic angina].
Topics: Adult; Angina Pectoris, Variant; Benzazepines; Clinical Trials as Topic; Coronary Vasospasm; Diltiazem; Ergonovine; Female; Humans; Male; Middle Aged; Placebos; Propranolol; Verapamil | 1981 |
Calcium antagonists: long-awaited new therapy for heart disease.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Benzazepines; Calcium; Cardiomyopathies; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Heart Diseases; Humans; Nifedipine; Pyridines; Verapamil | 1981 |
Hemodynamic effects of calcium ion antagonists after acute myocardial infarction.
Topics: Adult; Aged; Benzazepines; Blood Pressure; Clinical Trials as Topic; Diltiazem; Heart Rate; Humans; Middle Aged; Myocardial Infarction; Nifedipine; Pyridines; Stroke Volume; Vascular Resistance; Verapamil | 1980 |
Considerations in evaluating new antianginal drugs.
Topics: Angina Pectoris; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Drug Evaluation; Humans; Lidoflazine; Nifedipine; Research Design; Verapamil | 1982 |
Effects of calcium antagonists on adrenaline-induced hypokalaemia.
Topics: Adult; Aged; Blood Glucose; Calcium Channel Blockers; Diltiazem; Epinephrine; Hemodynamics; Humans; Hypokalemia; Middle Aged; Nitrendipine; Potassium; Renin; Verapamil | 1993 |
Intraindividual comparison of diltiazem and verapamil on induction of paroxysmal supraventricular tachycardia.
Topics: Adult; Aged; Diltiazem; Female; Humans; Male; Middle Aged; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil | 1994 |
Immunosuppressive effects of different calcium channel blockers in human kidney allografts.
Topics: Calcium; Calcium Channel Blockers; Cyclosporine; Cytokines; Diltiazem; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isradipine; Kidney Transplantation; Lymphocytes; Prednisolone; Transplantation, Homologous; Verapamil | 1995 |
Calcium antagonist-induced gingival hyperplasia.
Topics: Adult; Aged; Calcium Channel Blockers; Cross-Sectional Studies; Diltiazem; Gingival Hyperplasia; Humans; Hypertension; Male; Middle Aged; Nifedipine; Single-Blind Method; Verapamil | 1994 |
Dose of midazolam should be reduced during diltiazem and verapamil treatments.
Topics: Administration, Oral; Adult; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Midazolam; Psychomotor Performance; Verapamil | 1994 |
[Treatment of ischemic heart disease in the elderly. Comparison of diltiazem, verapamil and gallopamil].
Topics: Age Factors; Aged; Angina Pectoris; Coronary Angiography; Coronary Disease; Diltiazem; Drug Evaluation; Exercise Test; Female; Gallopamil; Humans; Male; Middle Aged; Myocardial Ischemia; Verapamil | 1993 |
Attenuation of cardiovascular responses to tracheal extubation: verapamil versus diltiazem.
Topics: Adult; Anesthesia; Blood Pressure; Calcium Channel Blockers; Diastole; Diltiazem; Female; Genitalia, Female; Heart Rate; Humans; Injections, Intravenous; Intubation, Intratracheal; Systole; Verapamil | 1996 |
Comparison of nifedipine alone and with diltiazem or verapamil in hypertension.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Data Interpretation, Statistical; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Time Factors; Verapamil | 1996 |
The effect of calcium channel antagonist administered by iontophoresis on the pain threshold.
Topics: Adult; Calcium Channel Blockers; Diltiazem; Drug Combinations; Female; Humans; Iontophoresis; Lidocaine; Male; Nicardipine; Pain; Sensory Thresholds; Time Factors; Verapamil | 1995 |
Comparison of nicardipine, diltiazem and verapamil for controlling the cardiovascular responses to tracheal intubation.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Diltiazem; Epinephrine; Female; Heart Rate; Hemodynamics; Humans; Intubation, Intratracheal; Laryngoscopy; Male; Middle Aged; Nicardipine; Norepinephrine; Preanesthetic Medication; Verapamil | 1996 |
Lack of effect of calcium channel blockers on open-angle glaucoma.
Topics: Aged; Calcium Channel Blockers; Diltiazem; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Middle Aged; Nifedipine; Optic Disk; Retrospective Studies; Treatment Failure; Verapamil; Visual Fields | 1996 |
Effects of calcium entry blockers on distribution of blood volume.
Topics: Blood Volume; Calcium Channel Blockers; Diltiazem; Female; Head-Down Tilt; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Posture; Vascular Capacitance; Vasoconstriction; Verapamil | 1996 |
[Calcium antagonist therapy of middle-aged and aged patients with angina pectoris during the outpatient stage of rehabilitation].
Topics: Age Factors; Aged; Aged, 80 and over; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Diltiazem; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Outpatients; Vasodilator Agents; Verapamil | 1995 |
The unnecessary controversy or lack of knowledge?
Topics: Calcium Channel Blockers; Cause of Death; Diltiazem; Humans; Risk Factors; Survival Rate; Ventricular Dysfunction, Left; Verapamil | 1997 |
Calcium channel blockers: an evidence-based review.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Verapamil | 1997 |
The influence of three L-type calcium channel blockers on morphine effects in healthy volunteers.
Topics: Adjuvants, Anesthesia; Adult; Affect; Analgesics, Opioid; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Double-Blind Method; Female; Humans; Male; Morphine; Nimodipine; Pain Threshold; Psychomotor Performance; Reference Values; Verapamil | 1997 |
Antianginal efficacy over 24 hours and exercise hemodynamic effects of once daily sustained-release 300 mg diltiazem and 240 mg verapamil in stable angina pectoris.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Cross-Over Studies; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Exercise; Female; Follow-Up Studies; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Safety; Treatment Outcome; Vasodilator Agents; Verapamil | 1998 |
Comparison of venodilatory effect of nicardipine, diltiazem, and verapamil in human subjects.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Diltiazem; Hand; Heart Rate; Humans; Male; Nicardipine; Vasodilator Agents; Veins; Verapamil | 1998 |
Effects of verapamil and diltiazem on the pharmacokinetics and pharmacodynamics of buspirone.
Topics: Adult; Buspirone; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Female; Humans; Male; Reference Values; Serotonin Receptor Agonists; Verapamil | 1998 |
Modulation of ventricular rate in permanent atrial fibrillation: randomized, crossover study of the effects of slow-release formulations of gallopamil, diltiazem, or verapamil.
Topics: Administration, Oral; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Cardiotonic Agents; Cross-Over Studies; Delayed-Action Preparations; Digoxin; Diltiazem; Electrocardiography, Ambulatory; Female; Gallopamil; Heart Rate; Humans; Male; Middle Aged; Verapamil | 1998 |
[Beta-adrenergic blockers and calcium antagonists in hypertrophic cardiomyopathy].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Diltiazem; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Penbutolol; Propranolol; Time Factors; Verapamil | 1998 |
Attenuation of anti-ischemic efficacy during chronic therapy with nicorandil in patients with stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Time Factors; Verapamil | 1999 |
Comparison of intravenous metoprolol, verapamil and diltiazem on the attenuation of haemodynamic changes associated with tracheal extubation.
Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Bradycardia; Diastole; Diltiazem; Heart Rate; Humans; Hypotension; Intervertebral Disc; Intubation, Intratracheal; Lumbar Vertebrae; Metoprolol; Middle Aged; Systole; Vasodilator Agents; Verapamil | 1999 |
Effects of intracoronary nicardipine, diltiazem and verapamil on coronary blood flow.
Topics: Aged; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Coronary Vessels; Diltiazem; Double-Blind Method; Female; Humans; Injections; Male; Middle Aged; Nicardipine; Verapamil | 2000 |
Long-term effects of diltiazem and verapamil on mortality and cardiac events in non-Q-wave acute myocardial infarction without pulmonary congestion: post hoc subset analysis of the multicenter diltiazem postinfarction trial and the second danish verapamil
Topics: Adult; Aged; Calcium Channel Blockers; Denmark; Diltiazem; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Pulmonary Edema; Retrospective Studies; Verapamil | 2000 |
Slow-infusion of calcium channel blockers in the emergency management of supraventricular tachycardia.
Topics: Calcium Channel Blockers; Diltiazem; Electrocardiography; Emergency Treatment; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Prospective Studies; Tachycardia, Supraventricular; Verapamil | 2002 |
Interaction between vasodilators and vasopressin in internal mammary artery and clinical significance.
Topics: Arginine Vasopressin; Coronary Artery Bypass; Coronary Restenosis; Culture Techniques; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Mammary Arteries; Middle Aged; Nifedipine; Nitroglycerin; Vasoconstriction; Vasodilator Agents; Verapamil | 2002 |
[Diltiazem and verapamil therapy in patients with angina pectoris associated with arterial hypotension].
Topics: Angina Pectoris; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Humans; Hypotension; Male; Middle Aged; Single-Blind Method; Treatment Outcome; Verapamil | 2004 |
In vivo performance of controlled release pellets of diltiazem HCl.
Topics: Adult; Antihypertensive Agents; Area Under Curve; Biological Availability; Capsules; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Diltiazem; Drug Administration Schedule; Half-Life; Humans; Male; Reference Standards; Therapeutic Equivalency; Verapamil | 2005 |
Differential effects of calcium-channel blockers on vascular endothelial function in patients with coronary spastic angina.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Coronary Vasospasm; Dihydropyridines; Diltiazem; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Vasodilation; Verapamil | 2009 |
Slow infusion of calcium channel blockers compared with intravenous adenosine in the emergency treatment of supraventricular tachycardia.
Topics: Adenosine; Adult; Anti-Arrhythmia Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Emergency Medical Services; Female; Heart Rate; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Prospective Studies; Tachycardia, Supraventricular; Treatment Outcome; Verapamil | 2009 |
REstoration of COronary flow in patients with no-reflow after primary coronary interVEntion of acute myocaRdial infarction (RECOVER).
Topics: Aged; Coronary Circulation; Diltiazem; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Nitroglycerin; Percutaneous Coronary Intervention; Prospective Studies; Treatment Outcome; Troponin T; Vasodilator Agents; Verapamil | 2012 |
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure.
Topics: Adult; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Male; Methadone; Middle Aged; Naloxone; Self Report; Substance Withdrawal Syndrome; Verapamil | 2013 |
How to limit radial artery spasm during percutaneous coronary interventions: The spasmolytic agents to avoid spasm during transradial percutaneous coronary interventions (SPASM3) study.
Topics: Aged; Analysis of Variance; Angioplasty, Balloon, Coronary; Cardiac Catheterization; Coronary Angiography; Coronary Stenosis; Diltiazem; Female; Follow-Up Studies; Humans; Isosorbide Dinitrate; Logistic Models; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Radial Artery; Spasm; Treatment Outcome; Vasoconstriction; Vasodilator Agents; Verapamil | 2014 |
Calcium channel blockers improve exercise capacity and reduce N-terminal Pro-B-type natriuretic peptide levels compared with beta-blockers in patients with permanent atrial fibrillation.
Topics: Adrenergic beta-Antagonists; Aged; Atrial Fibrillation; Calcium Channel Blockers; Carbazoles; Carvedilol; Cross-Over Studies; Delayed-Action Preparations; Diltiazem; Exercise Tolerance; Female; Humans; Male; Metoprolol; Natriuretic Peptide, Brain; Oxygen Consumption; Peptide Fragments; Propanolamines; Prospective Studies; Verapamil | 2014 |
Improved rate control reduces cardiac troponin T levels in permanent atrial fibrillation.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Biomarkers; Carbazoles; Carvedilol; Cross-Over Studies; Diltiazem; Down-Regulation; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Norway; Propanolamines; Prospective Studies; Time Factors; Treatment Outcome; Troponin T; Verapamil | 2014 |
Rate-control drugs affect variability and irregularity measures of RR intervals in patients with permanent atrial fibrillation.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Carbazoles; Carvedilol; Cross-Over Studies; Diltiazem; Electrocardiography, Ambulatory; Female; Heart Conduction System; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Norway; Propanolamines; Time Factors; Treatment Outcome; Verapamil | 2015 |
Troponin I levels in permanent atrial fibrillation-impact of rate control and exercise testing.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Biomarkers; Calcium Channel Blockers; Carbazoles; Carvedilol; Cross-Over Studies; Diltiazem; Down-Regulation; Exercise Test; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Norway; Predictive Value of Tests; Propanolamines; Treatment Outcome; Troponin I; Troponin T; Verapamil | 2016 |
Efficacy and Safety of Rivaroxaban Versus Warfarin in Patients Taking Nondihydropyridine Calcium Channel Blockers for Atrial Fibrillation (from the ROCKET AF Trial).
Topics: Administration, Oral; Aged; Anticoagulants; Atrial Fibrillation; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Factor Xa Inhibitors; Female; Humans; Male; Risk Factors; Rivaroxaban; Stroke; Treatment Outcome; Verapamil; Warfarin | 2017 |
1136 other study(ies) available for diltiazem and verapamil
| Article | Year |
|---|---|
A novel class of calcium-entry blockers: the 1[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
Topics: Animals; Binding Sites; Brain; Calcium Channel Blockers; Guinea Pigs; Indolizines; Male; Phenethylamines; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1992 |
Synthesis, calcium-channel-blocking activity, and antihypertensive activity of 4-(diarylmethyl)-1-[3-(aryloxy)propyl]piperidines and structurally related compounds.
Topics: Animals; Antihypertensive Agents; Aorta; Calcium; Calcium Channel Blockers; Hypertension; Male; Molecular Structure; Muscle Contraction; Piperidines; Rabbits; Rats; Rats, Inbred SHR; Structure-Activity Relationship | 1991 |
A new class of calcium antagonists. 2. Synthesis and biological activity of 11-[[4-[4-(4-fluorophenyl)-1-piperazinyl]butyryl]amino]-6,11- dihydrodibenzo[b,e]-thiepin maleate and related compounds.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Chemistry, Physical; Dibenzothiepins; Heart Rate; Hypertension; Male; Methacholine Chloride; Models, Molecular; Molecular Conformation; Molecular Structure; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Vasoconstriction | 1991 |
Aminoalkynyldithianes. A new class of calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Chemical Phenomena; Chemistry; Guinea Pigs; Heterocyclic Compounds; Muscle, Smooth; Structure-Activity Relationship | 1991 |
Synthesis and Ca2+ antagonistic activity of 2-[2-[(aminoalkyl)oxy]-5-methoxyphenyl]-3,4-dihydro-4-methyl-3-oxo-2H- 1,4-benzothiazines.
Topics: Animals; Aorta; Calcium Channel Blockers; Cecum; Diltiazem; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Structure-Activity Relationship; Thiazines; X-Ray Diffraction | 1990 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity.
Topics: Amines; Anesthetics, Local; Animals; Calcium Channel Blockers; Drug Evaluation, Preclinical; Heterocyclic Compounds; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Rabbits; Trachea | 1988 |
2-Ethynylbenzenealkanamines. A new class of calcium entry blockers.
Topics: Alkynes; Amines; Animals; Calcium Channel Blockers; Coronary Circulation; Guinea Pigs; Hypertension; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Vasodilation | 1988 |
Novel calcium antagonists. Synthesis and structure-activity relationship studies of benzothiazoline derivatives.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Guinea Pigs; Heart Conduction System; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Pulmonary Embolism; Rabbits; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Thiazoles | 1988 |
Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Computer Graphics; Diltiazem; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Models, Molecular; Myocardial Contraction; Nitrendipine; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Verapamil | 1995 |
Novel heterocyclic analogues of the new potent class of calcium entry blockers: 1-[[4-(aminoalkoxy)phenyl]sulfonyl]indolizines.
Topics: Animals; Calcium Channel Blockers; Cerebral Cortex; Guinea Pigs; Heterocyclic Compounds; Indolizines; Male; Muscle, Smooth, Vascular; Phenethylamines; Rats; Rats, Wistar; Structure-Activity Relationship | 1993 |
Cardiovascular characterization of pyrrolo[2,1-d][1,5]benzothiazepine derivatives binding selectively to the peripheral-type benzodiazepine receptor (PBR): from dual PBR affinity and calcium antagonist activity to novel and selective calcium entry blocker
Topics: Animals; Atrial Function; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cardiovascular System; Cerebral Cortex; Depression, Chemical; Female; Guinea Pigs; Heart Rate; Male; Models, Molecular; Myocardial Contraction; Myocardium; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Structure-Activity Relationship; Thiazepines | 1996 |
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
A new class of potential chloroquine-resistance reversal agents for Plasmodia: syntheses and biological evaluation of 1-(3'-diethylaminopropyl)-3-(substituted phenylmethylene)pyrrolidines.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Drug Resistance, Multiple; Heme; Heme Oxygenase (Decyclizing); Hemeproteins; Mice; Plasmodium; Pyrrolidines; Structure-Activity Relationship | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Fluoresceins; Fluorescent Dyes; Humans; Models, Molecular; Multivariate Analysis; Permeability; Quantitative Structure-Activity Relationship | 2005 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics.
Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results | 2006 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
New functional assay of P-glycoprotein activity using Hoechst 33342.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors | 2007 |
Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis.
Topics: Administration, Oral; Amlodipine; Animals; Antiprotozoal Agents; Dihydropyridines; Leishmania donovani; Leishmaniasis, Visceral; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Parasitic Sensitivity Tests; Treatment Outcome | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Models, Molecular; Molecular Structure; Neoplasm Proteins; Phthalic Acids; Quantitative Structure-Activity Relationship; Quinolines; Reproducibility of Results; Stereoisomerism; Time Factors; Tumor Cells, Cultured | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Comparative chemometric modeling of cytochrome 3A4 inhibitory activity of structurally diverse compounds using stepwise MLR, FA-MLR, PLS, GFA, G/PLS and ANN techniques.
Topics: Algorithms; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Factor Analysis, Statistical; Least-Squares Analysis; Linear Models; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; Reproducibility of Results | 2009 |
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Drug Resistance, Multiple; Magnetic Resonance Spectroscopy; Models, Molecular | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Effect of [6]-shogaol on cytosolic Ca2+ levels and proliferation in human oral cancer cells (OC2).
Topics: Calcium; Calcium Channels, L-Type; Catechols; Cell Line, Tumor; Cytosol; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Estrenes; Humans; Inositol 1,4,5-Trisphosphate; Molecular Structure; Mouth Neoplasms; Phospholipase A2 Inhibitors; Protein Kinase C; Pyrrolidinones; Thapsigargin | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Microsomes, Liver; Time Factors | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.
Topics: Amino Acids; Ascomycota; Calcium Channels, L-Type; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fermentation; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Vasodilator Agents | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Humans; Male; Microsomes, Liver; Myocytes, Cardiac; Oxadiazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Vasodilator Agents | 2016 |
[Calcium blocker (calcium antagonists) and angina pectoris].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Vessels; Calcium; Diltiazem; Female; Humans; Muscle Relaxation; Myocardium; Nifedipine; Vasodilator Agents; Verapamil | 1977 |
Effects of anti-anginal agents on cyclical reductions of coronary blood flow.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Blood Pressure; Coronary Circulation; Diltiazem; Dipyridamole; Dogs; Electrocardiography; Injections, Intravenous; Niacinamide; Nicotinic Acids; Nifedipine; Nitrates; Nitroglycerin; Papaverine; Periodicity; Phentolamine; Propranolol; Vasodilator Agents; Verapamil | 1978 |
Effect of 2-nicotinamidethyl nitrate (SG 75) on coronary circulation.
Topics: Animals; Constriction, Pathologic; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Heart Rate; Isosorbide Dinitrate; Ligation; Niacinamide; Nifedipine; Nitrates; Nitroglycerin; Papaverine; Vasodilator Agents; Verapamil | 1978 |
Effects of diltiazem and verapamil on the mechanical performance of the rabbit myocardium perfused with an oxygenated and hypoxic medium [proceedings].
Topics: Animals; Benzazepines; Diltiazem; In Vitro Techniques; Myocardial Contraction; Oxygen; Rabbits; Verapamil | 1979 |
[Coronary disease and calcium antagonists].
Topics: Angina Pectoris; Calcium; Coronary Disease; Diltiazem; Humans; Nifedipine; Verapamil | 1979 |
[Calcium antagonists].
Topics: Angina Pectoris; Arrhythmias, Cardiac; Benzazepines; Calcium; Diltiazem; Humans; Male; Middle Aged; Verapamil | 1978 |
Effects of calcium-antagonistic coronary vasodilators on myocardial contractility and membrane potentials.
Topics: Action Potentials; Animals; Benzazepines; Calcium; Depression, Chemical; Diltiazem; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Manganese; Membrane Potentials; Myocardial Contraction; Nifedipine; Potassium; Pyridines; Vasodilator Agents; Verapamil | 1977 |
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.
Topics: Action Potentials; Anesthetics, Local; Animals; Atrioventricular Node; Benzazepines; Calcium; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Female; Heart Conduction System; In Vitro Techniques; Injections; Lidocaine; Male; Neural Conduction; Nifedipine; Procaine; Quinidine; Vasodilator Agents; Verapamil | 1976 |
Selectivity scale of calcium antagonists in the human cardiovascular system based on in vitro studies.
Topics: Calcium; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Nifedipine; Nisoldipine; Vasoconstriction; Verapamil | 1992 |
Frequency-dependent depression of Vmax in K(+)-depolarized guinea pig papillary muscle by tetrandrine.
Topics: Action Potentials; Alkaloids; Animals; Benzylisoquinolines; Calcium Channel Blockers; Diltiazem; Electrophysiology; Female; Guinea Pigs; Male; Nitrendipine; Papillary Muscles; Verapamil | 1992 |
Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Diltiazem; Drosophila melanogaster; Eye Proteins; Light; Phosphoproteins; Phosphorylation; Photoreceptor Cells; Retinal Degeneration; Verapamil | 1992 |
Lack of effect of chronic calcium antagonist treatment on beta 1- and beta 2-adrenoceptors in right atria from patients with or without heart failure.
Topics: Adult; Aged; Calcium Channel Blockers; Coronary Artery Bypass; Coronary Disease; Diltiazem; Female; Heart Atria; Humans; Lymphocytes; Male; Middle Aged; Nifedipine; Receptors, Adrenergic, beta; Verapamil | 1992 |
Effects of diltiazem and verapamil on (+)-PN 200-110 binding kinetics in dog cardiac membranes.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dogs; Female; In Vitro Techniques; Isradipine; Kinetics; Male; Myocardium; Receptors, Nicotinic; Temperature; Verapamil | 1992 |
Inhibition of sodium pump by bepridil. An in vitro and microcalorimetric study.
Topics: Adenosine Triphosphate; Bepridil; Diltiazem; Erythrocytes; Humans; Kinetics; Nicardipine; Nifedipine; Ouabain; Potassium; Sodium-Potassium-Exchanging ATPase; Verapamil | 1992 |
Effects of verapamil, gallopamil, diltiazem and nifedipine on sarcoplasmic reticulum function in rat heart.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Diltiazem; Gallopamil; Heart; Nifedipine; Rats; Rats, Sprague-Dawley; Ryanodine; Sarcoplasmic Reticulum; Verapamil | 1992 |
Density of 1,4-dihydropyridine receptors decreases in the hearts of aging hamsters.
Topics: Aging; Allosteric Site; Animals; Calcium Channels; Cricetinae; Dihydropyridines; Diltiazem; In Vitro Techniques; Kinetics; Male; Myocardium; Nifedipine; Verapamil | 1992 |
Modulation of high affinity phenylalkylamine binding sites on cultured human embryonal vascular smooth muscle cells.
Topics: Binding Sites; Calcium Channels; Cells, Cultured; Diltiazem; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Isoproterenol; Kinetics; Magnesium; Muscle, Smooth, Vascular; Potassium; Verapamil | 1992 |
Effects of Ca2+ antagonists and antiepileptics on tetrodotoxin-sensitive Ca(2+)-conducting channels in isolated rat hippocampal CA1 neurons.
Topics: Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Hippocampus; Kinetics; Neurons; Nicardipine; Phenobarbital; Phenytoin; Pyramidal Tracts; Rats; Rats, Wistar; Sodium; Tetrodotoxin; Valproic Acid; Verapamil | 1992 |
[Therapy of coronary disease].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dipyridamole; Drug Therapy, Combination; Humans; Isosorbide Dinitrate; Metoprolol; Nitrates; Smoking; Verapamil | 1992 |
The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Colchicine; Daunorubicin; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Ileum; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Membrane Glycoproteins; Microvilli; Rats; Rats, Inbred Strains; Rhodamine 123; Rhodamines; Temperature; Verapamil | 1992 |
Effect of ethosuximide on rest tremor in the MPTP monkey model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Diltiazem; Dopamine Agents; Dose-Response Relationship, Drug; Electromyography; Ergolines; Ethosuximide; Female; Macaca fascicularis; Neurologic Examination; Parkinson Disease, Secondary; Quinpirole; Tremor; Verapamil | 1992 |
Effects of the calcium antagonists diltiazem, verapamil and nitrendipine on the contractile responses of guinea-pig isolated ileum to electrical stimulation or carbachol.
Topics: Animals; Carbachol; Diltiazem; Electric Stimulation; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nitrendipine; Potassium Chloride; Verapamil | 1992 |
In archaebacteria, there is a doxorubicin efflux pump similar to mammalian P-glycoprotein.
Topics: Animals; Archaea; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bacillus subtilis; Biological Transport, Active; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Division; Diltiazem; Doxorubicin; Drug Resistance, Microbial; Drug Synergism; Flow Cytometry; Fluorescent Dyes; Mammals; Membrane Glycoproteins; Nifedipine; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1992 |
Failure of verapamil and diltiazem to attenuate the pressor response to hypothalamic stimulation: a possible mechanism.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Desoxycorticosterone; Diltiazem; Electric Stimulation; Female; Hypertension; Hypertension, Renal; Hypothalamus, Posterior; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tyramine; Verapamil | 1992 |
Cardiovascular effects of LAS 30538, a new vascular selective Ca(2+)-channel blocker.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Electrophysiology; Flunarizine; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Papillary Muscles; Perfusion; Piperidines; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1992 |
The calcium channel blocker LAS 30538, unlike nifedipine, verapamil, diltiazem or flunarizine, potently inhibits insulin secretion in-vivo in rats and dogs.
Topics: Administration, Oral; Animals; Blood Glucose; Calcium Channel Blockers; Diltiazem; Dogs; Female; Flunarizine; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nifedipine; Piperidines; Rats; Rats, Sprague-Dawley; Verapamil | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Diltiazem; Drug Synergism; Flunarizine; Mice; Mice, Inbred DBA; Nimodipine; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Verapamil | 1992 |
Comparative effects of diltiazem, nifedipine, and verapamil on large and small coronary artery constriction induced by intracoronary acetylcholine in pigs.
Topics: Acetylcholine; Angiocardiography; Animals; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Injections, Intravenous; Nifedipine; Swine; Vasoconstriction; Verapamil | 1992 |
Calcium channel blocker treatment of tumor cells induces alterations in the cytoskeleton, mobility of the integrin alpha IIb beta 3 and tumor-cell-induced platelet aggregation.
Topics: Animals; Calcium Channel Blockers; Carcinoma 256, Walker; Cytoskeleton; Diltiazem; Epitopes; Female; Integrins; Microscopy, Electron; Microtubules; Nifedipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tumor Cells, Cultured; Verapamil | 1992 |
Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Atenolol; Calcium; Diltiazem; Endothelium, Vascular; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Potassium Chloride; Quinazolines; Rats; Rats, Inbred Strains; Stereoisomerism; Verapamil | 1992 |
Inotropic effects of calcium antagonists in the cardiomyopathic Syrian hamster.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Cricetinae; Depression, Chemical; Diltiazem; Gallopamil; Mesocricetus; Myocardial Contraction; Nifedipine; Stimulation, Chemical; Verapamil | 1992 |
Slow channel calcium blockers attenuate reoxygenation-mediated vascular contraction, but augment anoxia-mediated vascular contraction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta; Diltiazem; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Oxyhemoglobins; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Thromboxane A2; Vasoconstriction; Verapamil | 1992 |
The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Brain; Calcium Channels; Diltiazem; Drug Interactions; Guinea Pigs; Heart; Nitrendipine; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tritium; Verapamil | 1992 |
Differential potentiation by calcium antagonists of neuromuscular blockade induced by pancuronium and succinylcholine in cats in vivo.
Topics: Animals; Calcium Channel Blockers; Cats; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Female; Male; Neuromuscular Blocking Agents; Nicardipine; Pancuronium; Stereoisomerism; Succinylcholine; Verapamil | 1992 |
Cytosolic calcium increase in coronary endothelial cells after H2O2 exposure and the inhibitory effect of U78517F.
Topics: Animals; Calcium; Catalase; Cells, Cultured; Chromans; Coronary Vessels; Cytosol; Diltiazem; Endothelium, Vascular; Free Radical Scavengers; Hydrogen Peroxide; In Vitro Techniques; Lipid Peroxidation; Nifedipine; Piperazines; Swine; Verapamil | 1992 |
Antinociceptive effects of Ca2+ channel blockers.
Topics: Analgesics; Analysis of Variance; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Mice; Morphine; Nifedipine; Nimodipine; Pain Measurement; Rats; Rats, Wistar; Verapamil | 1992 |
Effects of calcium channel blockers on the contractility of the filariid Acanthocheilonema viteae.
Topics: Acetylcholine; Animals; Cadmium; Calcium; Calcium Channel Blockers; Diltiazem; Dipetalonema; Egtazic Acid; Female; Muscle Contraction; Nifedipine; Tetrodotoxin; Verapamil | 1992 |
Cardiac glycosides in the treatment of experimental overdose with calcium-blocking agents.
Topics: Animals; Atropine; Calcium; Calcium Channel Blockers; Calcium Gluconate; Depression, Chemical; Digoxin; Diltiazem; Dogs; Drug Overdose; Electrocardiography; Female; Hemodynamics; Humans; Male; Myocardium; Verapamil | 1992 |
[Changes in the relative levels of fatty acids in blood and myocardium in the Prague breed of rats with hereditary hypercholesteremia after administration of slow calcium channel blockers].
Topics: Animals; Diltiazem; Fatty Acids; Hypercholesterolemia; Myocardium; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Effects of calcium channel blockers on calcium uptake in rat aortic valve allografts.
Topics: Analysis of Variance; Animals; Aortic Valve; Calcium; Calcium Channel Blockers; Diltiazem; Electron Probe Microanalysis; Male; Rats; Transplantation, Homologous; Transplantation, Isogeneic; Verapamil | 1992 |
[Effects of calcium blockers on the performance of left and right ventricles during acute hypoxia].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Hemodynamics; Hypoxia; Male; Nifedipine; Ventricular Function; Verapamil | 1992 |
Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet.
Topics: Animals; Blood; Calcium; Clofibrate; Dietary Fats; Diltiazem; Felodipine; Lipids; Male; Nifedipine; Nimodipine; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Anoxia/reoxygenation injury in hepatocytes is not prevented by calcium channel blockers.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cells, Cultured; Culture Media; Diltiazem; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Liver; Male; Nifedipine; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Verapamil | 1992 |
Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers.
Topics: Aspirin; Calcium Channel Blockers; Chemotaxis, Leukocyte; Diltiazem; Dose-Response Relationship, Drug; Endothelins; Humans; In Vitro Techniques; Indomethacin; Kinetics; Monocytes; Neomycin; Nifedipine; Probucol; Thioctic Acid; Verapamil | 1992 |
Protection by Ca2+ channel blockers (nifedipine, diltiazem and verapamil) against the toxicity of oxidized low density lipoprotein to cultured lymphoid cells.
Topics: Antioxidants; Calcium Channel Blockers; Cells, Cultured; Cholesterol Esters; Diltiazem; Humans; Lipid Peroxidation; Lipoproteins, LDL; Lymphoid Tissue; Nifedipine; Oxidation-Reduction; Verapamil | 1992 |
Relaxation effects of diltiazem, verapamil, and tolazoline on isolated cat ophthalmociliary artery.
Topics: Animals; Cats; Diltiazem; Dose-Response Relationship, Drug; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ophthalmic Artery; Tolazoline; Verapamil | 1992 |
Ro 40-5967, a novel calcium channel antagonist, protects against ventricular fibrillation.
Topics: Animals; Benzimidazoles; Binding Sites; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Disease Susceptibility; Dogs; Dose-Response Relationship, Drug; Heart Rate; Mibefradil; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Physical Exertion; Tetrahydronaphthalenes; Ventricular Fibrillation; Verapamil | 1992 |
Difference in the effects of verapamil on Ca(2+)-activated K+ channels of smooth myocytes of aorta and taenia coli.
Topics: Animals; Aorta; Calcium; Cell Separation; Colon; Diltiazem; Electrophysiology; Guinea Pigs; In Vitro Techniques; Muscle, Smooth; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Rats; Verapamil | 1992 |
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil | 1992 |
Inhibition of cancer cell growth by calcium channel antagonists in the athymic mouse.
Topics: Amlodipine; Animals; Breast Neoplasms; Calcium; Calcium Channel Blockers; Cell Division; Culture Media; Diltiazem; DNA, Neoplasm; Drug Screening Assays, Antitumor; Mice; Mice, Nude; Nifedipine; Tumor Cells, Cultured; Verapamil | 1992 |
[Are all calcium antagonists alike?].
Topics: Calcium Channel Blockers; Coronary Disease; Diltiazem; Humans; Hypertension; Nifedipine; Verapamil | 1992 |
Effect of calcium channel antagonists on cell membrane potential oscillations and proliferation of cells expressing the ras oncogene.
Topics: 3T3 Cells; Animals; Bradykinin; Calcium Channel Blockers; Cell Division; Diltiazem; Gene Expression; Genes, ras; Membrane Potentials; Mice; Nifedipine; Transfection; Verapamil | 1992 |
[The effects of calcium antagonists on ventilation-perfusion mismatching in the canine lung].
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Hypoxia; Models, Biological; Nifedipine; Oxygen; Partial Pressure; Pulmonary Artery; Pulmonary Gas Exchange; Vasoconstriction; Ventilation-Perfusion Ratio; Verapamil | 1992 |
Antioxidant effects of calcium channel blockers against free radical injury in endothelial cells. Correlation of protection with preservation of glutathione levels.
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Calcium Channel Blockers; Cattle; Cell Survival; Cells, Cultured; Diltiazem; Endothelium, Vascular; Free Radicals; Glutathione; Lipid Peroxidation; Nicardipine; Nifedipine; Sarcolemma; Verapamil | 1992 |
Calcium antagonists block angiotensin II-mediated vasoconstriction in humans: comparison with their effect on phenylephrine-induced vasoconstriction.
Topics: Adult; Angiotensin II; Diltiazem; Forearm; Humans; Infusions, Intravenous; Male; Nifedipine; Phenylephrine; Vascular Resistance; Vasoconstriction; Verapamil | 1992 |
Ventricular tachycardia of right bundle-branch block--left axis deviation morphology and organic heart disease.
Topics: Adolescent; Aged; Bundle of His; Bundle-Branch Block; Cardiac Pacing, Artificial; Combined Modality Therapy; Coronary Artery Bypass; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Electrocardiography; Humans; Male; Tachycardia; Verapamil | 1992 |
Effects of calcium channel blockers on formalin-induced nociception and inflammation in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Diltiazem; Formaldehyde; Hindlimb; Inflammation; Male; Nicardipine; Nitrendipine; Pain; Pain Measurement; Rats; Verapamil | 1992 |
Effects of thioridazine on mechanical responses of human vas deferens induced by noradrenaline or potassium.
Topics: Culture Techniques; Diltiazem; Humans; Male; Muscle Contraction; Norepinephrine; Phentolamine; Potassium; Prazosin; Thioridazine; Vas Deferens; Verapamil | 1992 |
Influence of calcium antagonists on thrombin-induced calcium mobilization and platelet-vessel wall interactions.
Topics: Aspirin; Blood Platelets; Calcium; Calcium Channel Blockers; Cytosol; Diltiazem; Endothelium, Vascular; Humans; In Vitro Techniques; Nifedipine; Thrombin; Verapamil | 1992 |
Effect of voltage-sensitive calcium channel antagonists on the release of 5-hydroxytryptamine from rat hippocampus in vivo.
Topics: Animals; Calcium; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Male; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Rats; Rats, Inbred Strains; Serotonin; Verapamil | 1992 |
Diverse effects of calcium channel blockers on skeletal muscle glucose transport.
Topics: 3-O-Methylglucose; Animals; Biological Transport; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Glucose; Hypoxia; Male; Methylglucosides; Muscles; Nifedipine; Rats; Rats, Inbred Strains; Stereoisomerism; Verapamil | 1992 |
Inhibition of K(+)-evoked [3H]D-aspartate release and neuronal calcium influx by verapamil, diltiazem and dextromethorphan: evidence for non-L/non-N voltage-sensitive calcium channels.
Topics: Animals; Aspartic Acid; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Cells, Cultured; Cerebral Cortex; Dextromethorphan; Diltiazem; Hippocampus; Male; Neurons; Nifedipine; omega-Conotoxin GVIA; Peptides, Cyclic; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140.
Topics: Alkaloids; Allosteric Regulation; Animals; Benzothiazoles; Benzylisoquinolines; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebral Cortex; Diltiazem; Guinea Pigs; Isomerism; Isradipine; Kinetics; Macromolecular Substances; Models, Theoretical; Muscles; Oxadiazoles; Pyridines; Pyrrolidines; Rabbits; Thiazoles; Verapamil | 1991 |
Comparative effects of a new calcium channel antagonist, mepirodipine, on rabbit spontaneously beating sino-atrial node cells.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Female; In Vitro Techniques; Male; Nifedipine; Rabbits; Sinoatrial Node; Verapamil | 1991 |
Cholecystokinin-induced phosphatidylinositol hydrolysis in rat pancreatic acinar cells: modulation by extracellular calcium and manganese.
Topics: Animals; Calcium; Cell Line; Diltiazem; Egtazic Acid; Hydrolysis; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lanthanum; Male; Manganese; Nifedipine; Pancreas; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Rats; Rats, Inbred Strains; Sincalide; Verapamil | 1991 |
The binding and functional properties of voltage dependent calcium channel receptors in pediatric normal and myelodysplastic bladders.
Topics: Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Child; Diltiazem; Dose-Response Relationship, Drug; Humans; Muscle Contraction; Muscle, Smooth; Neural Tube Defects; Nifedipine; Receptors, Nicotinic; Urinary Bladder; Verapamil | 1991 |
Calcium antagonists increase the amount of mRNA for the low-density lipoprotein receptor in skin fibroblasts.
Topics: Blotting, Northern; Calcium Channel Blockers; Cells, Cultured; Diltiazem; DNA; Fibroblasts; Humans; Lipoproteins, LDL; Receptors, Cell Surface; Receptors, Lipoprotein; RNA, Messenger; Skin; Up-Regulation; Verapamil | 1991 |
Effect of calcium-channel blockers on alcohol consumption in alcohol-drinking monkeys.
Topics: Alcohol Drinking; Alcoholism; Animals; Brain; Calcium Channels; Diltiazem; Dose-Response Relationship, Drug; Female; Macaca; Male; Verapamil | 1991 |
The devapamil-binding site of the purified skeletal muscle receptor for organic-calcium channel blockers is modulated by micromolar and millimolar concentrations of Ca2+.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Kinetics; Ligands; Muscles; Rabbits; Receptors, Nicotinic; Verapamil | 1991 |
Role of calcium in regulation of phosphoinositide signaling pathway.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Carbachol; Cations, Divalent; Cells, Cultured; Cerebral Cortex; Diltiazem; Egtazic Acid; Inositol; Inositol Phosphates; Isradipine; Kinetics; Models, Neurological; Neurons; Oxadiazoles; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Rats; Signal Transduction; Sulfonamides; Verapamil | 1991 |
Calcium channel antagonists and human immunodeficiency virus coat protein-mediated neuronal injury.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Survival; Cells, Cultured; Dihydropyridines; Diltiazem; Flunarizine; HIV Envelope Protein gp120; HIV-1; Peptide Fragments; Rats; Recombinant Fusion Proteins; Retinal Ganglion Cells; Verapamil | 1991 |
Rapid desensitization of central beta-adrenoceptors in rat after subacute treatment with imipramine and calcium entry blockers.
Topics: 1-Propanol; Animals; Calcium Channel Blockers; Clonidine; Diltiazem; DOM 2,5-Dimethoxy-4-Methylamphetamine; Drinking Behavior; Fenclonine; Imipramine; Isoproterenol; Ketanserin; Nicardipine; Nifedipine; Oxidopamine; Rats; Receptors, Adrenergic, beta; Verapamil | 1991 |
Responses of osteoblastic cell line MC3T3-E1 cell to the calcium channel blocker diltiazem and verapamil.
Topics: Animals; Cell Line; Collagen; Diltiazem; DNA; Mice; Microbial Collagenase; Osteoblasts; Protein Biosynthesis; Verapamil | 1991 |
Cromakalim (BRL 34915) counteracts the epileptiform activity elicited by diltiazem and verapamil in rats.
Topics: Animals; Anticonvulsants; Benzopyrans; Cromakalim; Diltiazem; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Pentobarbital; Pyrroles; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission; Verapamil | 1991 |
Organic Ca(2+)-antagonist-resistant response to FMRF-NH2 on the molluscan smooth muscle.
Topics: Animals; Bivalvia; Calcium; Calcium Channel Blockers; Chlorides; Diltiazem; FMRFamide; In Vitro Techniques; Manganese; Manganese Compounds; Muscle, Smooth; Neuropeptides; Neurotransmitter Agents; Potassium Chloride; Verapamil | 1991 |
Inhibition of human mesangial cell proliferation by calcium channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcium Channel Blockers; Cell Division; Cells, Cultured; Dantrolene; Diltiazem; Glomerular Mesangium; Humans; Nifedipine; Platelet-Derived Growth Factor; Thrombin; Thymidine; Verapamil | 1990 |
Effects of pinaverium on voltage-activated calcium channel currents of single smooth muscle cells isolated from the longitudinal muscle of the rabbit jejunum.
Topics: Animals; Barium; Calcium Channels; Diltiazem; Flunarizine; Gallopamil; In Vitro Techniques; Ion Channels; Jejunum; Membrane Potentials; Morpholines; Muscle, Smooth; Parasympatholytics; Rabbits; Verapamil | 1990 |
Negative inotropic properties of isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardial tissue.
Topics: Adult; Aged; Calcium Channel Blockers; Calcium Chloride; Diltiazem; Electric Stimulation; Female; Heart; Heart Diseases; Humans; In Vitro Techniques; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Papillary Muscles; Pyridines; Verapamil | 1990 |
Involvement of the cellular vacuolar system with the cytotoxicity of bleomycin-like agents.
Topics: Animals; Bleomycin; Cell Nucleus; Cell Survival; Diltiazem; DNA Damage; Hydrogen-Ion Concentration; Intracellular Fluid; Leukemia L1210; Tumor Cells, Cultured; Vacuoles; Verapamil | 1990 |
Reentrant fascicular tachycardia with cycle length alternans: insights into the tachycardia mechanism and origin.
Topics: Bundle of His; Bundle-Branch Block; Cardiac Pacing, Artificial; Diltiazem; Electrocardiography; Electrocardiography, Ambulatory; Humans; Male; Middle Aged; Purkinje Fibers; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular; Time Factors; Verapamil | 1990 |
Effect of calcium-modifying drugs on glutamate dehydrogenase and isocitrate dehydrogenase activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Diltiazem; Glutamate Dehydrogenase; Homeostasis; In Vitro Techniques; Isocitrate Dehydrogenase; Kinetics; Mitochondria, Heart; Rats; Verapamil | 1990 |
Transmembrane ion conductance in human B lymphocyte activation.
Topics: 4-Aminopyridine; B-Lymphocytes; Calcimycin; Calcium; Cell Cycle; Diltiazem; Electric Conductivity; Humans; Immunoglobulin mu-Chains; In Vitro Techniques; Ion Channels; Lymphocyte Activation; Membrane Potentials; Potassium Channels; Receptors, Antigen, B-Cell; Tetradecanoylphorbol Acetate; Tetraethylammonium Compounds; Verapamil | 1990 |
An endogenous Ca2+ channel agonist, endothelin-1, does not directly activate partially purified dihydropyridine-sensitive Ca2+ channel from cardiac muscle in a reconstituted system.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Endothelins; Heart; Isradipine; Kinetics; Liposomes; Microsomes; Oxadiazoles; Proteolipids; Sarcolemma; Swine; Verapamil | 1990 |
Bay K 8644, modifier of calcium transport and energy metabolism in rat heart mitochondria: a new intracellular site of action.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Diphosphate; Animals; Biological Transport, Active; Calcium; Diltiazem; Energy Metabolism; Female; Glutamates; In Vitro Techniques; Malates; Mitochondria, Heart; NAD; Nitrendipine; Oxidation-Reduction; Oxygen Consumption; Rats; Ruthenium Red; Verapamil | 1990 |
Separate [3H]-nitrendipine binding sites in mitochondria and plasma membranes of bovine adrenal medulla.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium Channels; Cattle; Cell Membrane; Chromaffin System; Diltiazem; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Mitochondria; Nitrendipine; Receptors, Nicotinic; Stereoisomerism; Subcellular Fractions; Verapamil | 1990 |
Inhibitory effects of diltiazem, verapamil, nifedipine, and nicardipine on sympathetic tachycardia in decentralized hearts of anesthetized dogs.
Topics: Analysis of Variance; Animals; Blood Pressure; Coronary Circulation; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Male; Nicardipine; Nifedipine; Pentobarbital; Sympathetic Nervous System; Tachycardia; Verapamil | 1990 |
Differential effects of calcium antagonists and Bay K 8644 on contractile responses to exogenous noradrenaline and adrenergic nerve stimulation in the rabbit ear artery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Calcium; Calcium Channel Blockers; Diltiazem; Ear, External; Electric Stimulation; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Rabbits; Sympathetic Nervous System; Tetrodotoxin; Verapamil | 1990 |
A comparative study of histamine and K+ effects on (Ca(2+)-Mg2+)-ATPase activity in synaptosomes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Ca(2+) Mg(2+)-ATPase; Calcium Chloride; Calcium-Transporting ATPases; Cell Membrane; Choline; Diltiazem; Dose-Response Relationship, Drug; Histamine; Potassium; Pyrilamine; Ranitidine; Rats; Sodium; Synapses; Synaptosomes; Verapamil | 1991 |
Evidence for a link between mechanical and electrical alternans in acutely ischaemic myocardium of anaesthetized dogs.
Topics: Animals; Calcium Channel Blockers; Cardiac Complexes, Premature; Coronary Disease; Diltiazem; Dogs; Electric Stimulation; Myocardial Contraction; Physical Stimulation; Pulse; Verapamil | 1991 |
Effects of calcium-channel blockers on cytosolic free calcium and amylase secretion in rat pancreatic acini.
Topics: Amylases; Animals; Bombesin; Calcium; Calcium Channel Blockers; Carbachol; Ceruletide; Cytosol; Diltiazem; In Vitro Techniques; Male; N-Methylscopolamine; Pancreas; Peptide Fragments; Rats; Rats, Inbred Strains; Scopolamine Derivatives; Verapamil | 1991 |
Effects of calcium-modifying agents on integrity of rabbit isolated gastric mucosal cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Cell Separation; Diltiazem; Ethanol; Gastric Mucosa; In Vitro Techniques; Nifedipine; Protease Inhibitors; Rabbits; Trypan Blue; Verapamil | 1991 |
Effects of calcium channel blockers on stress protein synthesis in cardiac myocytes.
Topics: Animals; Cadmium; Cadmium Chloride; Calcium; Calcium Channel Blockers; Cardiac Glycosides; Cells, Cultured; Diltiazem; Drug Synergism; Heat-Shock Proteins; Hydrogen Peroxide; Mice; Myocardial Contraction; Myocardium; Nifedipine; Time Factors; Verapamil | 1991 |
Evidence for a central component in the cardiovascular effects of calcium channel blockers.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Cats; Diltiazem; Female; Heart Rate; Male; Verapamil | 1991 |
Differential effects of L-type calcium channel blockers and stimulants on naloxone-precipitated withdrawal in mice acutely dependent on morphine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Mice; Morphine Dependence; Naloxone; Nicardipine; Postural Balance; Substance Withdrawal Syndrome; Verapamil | 1991 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
The hemodynamic effects of lacidipine in anesthetized dogs: comparison with nitrendipine, amlodipine, verapamil, and diltiazem.
Topics: Amlodipine; Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Nifedipine; Nitrendipine; Stroke Volume; Vascular Resistance; Verapamil | 1991 |
Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlodipine.
Topics: Amlodipine; Animals; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Hemodynamics; Male; Mibefradil; Nifedipine; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes; Verapamil | 1991 |
Calcium channel blockers nifedipine and diltiazem inhibit Ca2+ release from intracellular stores in neutrophils.
Topics: Adult; Calcium; Calcium Radioisotopes; Cytoplasm; Diltiazem; Erythrocytes; Humans; Immunoglobulin G; In Vitro Techniques; Kinetics; Models, Biological; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nifedipine; Phagocytosis; Phorbol 12,13-Dibutyrate; Radioisotope Dilution Technique; Verapamil | 1992 |
Effects of Ca2+ antagonists on NA-induced intracellular Ca2+ mobilization in rat cultured neurons.
Topics: Animals; Calcium; Cells, Cultured; Diltiazem; Frontal Lobe; Intracellular Fluid; Neurons; Nicardipine; Norepinephrine; Prazosin; Rats; Verapamil | 1991 |
In vitro effects of two novel calcium antagonists (nitrendipine and nisoldipine) on intraplatelet calcium redistribution, platelet aggregation and thromboxane A2 formation. Comparison with diltiazem, nifedipine and verapamil.
Topics: Adult; Blood Platelets; Calcium; Calcium Channel Blockers; Diltiazem; Female; Humans; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Nitrendipine; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Verapamil | 1991 |
Sensitivity and transduction mechanisms of responses to general odorants in turtle vomeronasal system.
Topics: Amiloride; Animals; Chemoreceptor Cells; Chlorides; Cilia; Diltiazem; Dose-Response Relationship, Drug; Odorants; Olfactory Bulb; Olfactory Pathways; Signal Transduction; Sodium Chloride; Sulfates; Turtles; Verapamil | 1991 |
Protection against ischaemic ventricular fibrillation by blocking agents of myocardial cell calcium influx. Electrophysiological study in the pig in situ heart.
Topics: Animals; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Electrophysiology; Myocardium; Nicardipine; Sarcolemma; Swine; Ventricular Fibrillation; Verapamil | 1991 |
Calcium-channel blocking agents verapamil and diltiazem are inhibitors of vasopressin-induced human platelet activation.
Topics: Adult; Arginine Vasopressin; Diltiazem; Egtazic Acid; Humans; In Vitro Techniques; Lypressin; Male; Platelet Activation; Thromboxane B2; Vasopressins; Verapamil | 1991 |
Calcium channel blockers and prostaglandin generation by gastric surface epithelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcium; Calcium Channel Blockers; Calmodulin; Diltiazem; Dinoprostone; Epithelium; Gastric Mucosa; Male; Nifedipine; Rats; Rats, Inbred Strains; Sulfonamides; Verapamil | 1991 |
The effects of calcium antagonists on extracellular potassium accumulation during global ischaemia in isolated perfused rat hearts.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Electrodes; Extracellular Space; Heart; Kinetics; Male; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Ventricular Function, Left; Verapamil | 1991 |
Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Kidney Diseases; Kidney Tubules; Leucine; Microscopy, Fluorescence; Nifedipine; Rabbits; Time Factors; Verapamil | 1991 |
Calcium channel blockade inhibits platelet activating factor production by human umbilical vein endothelial cells.
Topics: Bradykinin; Cells, Cultured; Diltiazem; Endothelium, Vascular; Humans; Kinetics; Lanthanum; Platelet Activating Factor; Thrombin; Umbilical Veins; Verapamil | 1991 |
Negative inotropic activity of the calcium antagonists isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardium.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Heart Diseases; Humans; Hypertension; Isradipine; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Pyridines; Vasodilation; Verapamil | 1991 |
Differential ontogeny of in vitro vascular responses to three categories of calcium channel antagonists in rats.
Topics: Age Factors; Animals; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels; Diltiazem; Female; In Vitro Techniques; Male; Nifedipine; Rats; Rats, Inbred Strains; Vasodilation; Verapamil | 1991 |
Experience with calcium antagonists nitrendipine, diltiazem, and verapamil and beta 2-agonist salbutamol in salvaging ischemic skin flaps in rabbits.
Topics: Albuterol; Animals; Calcium Channel Blockers; Diltiazem; Injections, Intravenous; Ischemia; Necrosis; Nitrendipine; Rabbits; Reperfusion; Skin; Surgical Flaps; Verapamil | 1991 |
Chronic oral treatment with diltiazem or verapamil decreases isolation-induced activity impairment in elevated plus maze.
Topics: Animals; Arousal; Diltiazem; Discrimination Learning; Dose-Response Relationship, Drug; Fear; Male; Motor Activity; Orientation; Rats; Rats, Inbred Strains; Social Isolation; Verapamil | 1991 |
Effects of brain biogenic amines of repeated treatments with calcium antagonists.
Topics: Animals; Biogenic Amines; Brain; Chromatography, High Pressure Liquid; Diltiazem; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Antiarrhythmic drugs impair hepatic uptake and secretory function by different mechanisms in the isolated perfused rat liver.
Topics: Animals; Anti-Arrhythmia Agents; Bile; Blood Pressure; Diltiazem; In Vitro Techniques; Liver; Male; Prajmaline; Rats; Rats, Inbred Strains; Regional Blood Flow; Verapamil | 1991 |
Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists.
Topics: Animals; Bepridil; Caffeine; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Fendiline; Flunarizine; Kinetics; Lidoflazine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rabbits; Renal Artery; Verapamil | 1991 |
Effect of calcium channel blocking agents on the reductive metabolism of halothane.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Halothane; Male; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Nicardipine; Oxidation-Reduction; Verapamil | 1991 |
Diltiazem and verapamil lower blood pressure in the unanaesthetized rat through CNS mechanisms involving endogenous opioids.
Topics: Animals; Blood Pressure; Brain; Consciousness; Diltiazem; Endorphins; Heart Rate; Injections, Intraventricular; Naloxone; Rats; Rats, Inbred Strains; Time Factors; Verapamil | 1991 |
Effect of drugs on the lethality in mice of the venoms and neurotoxins from sundry snakes.
Topics: Animals; Dexamethasone; Diltiazem; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Neuromuscular Depolarizing Agents; Neurotoxins; Nicergoline; Nifedipine; Piperidines; Piracetam; Primaquine; Reserpine; Snake Venoms; Snakes; Verapamil | 1991 |
Effects of calcium channel blocker overdose-induced toxicity in the conscious dog.
Topics: Animals; Coronary Circulation; Diltiazem; Dogs; Drug Overdose; Female; Hemodynamics; Infusions, Intravenous; Male; Nifedipine; Verapamil | 1991 |
Effects of bepridil, diltiazem and verapamil on atrial refractoriness and heart rate in the conscious dog: comparison with quinidine.
Topics: Animals; Arrhythmias, Cardiac; Atrial Function, Right; Bepridil; Blood Pressure; Diltiazem; Dogs; Female; Heart; Heart Rate; Male; Pressoreceptors; Quinidine; Tachycardia; Verapamil | 1991 |
Calcium antagonists inhibit contractions to norepinephrine in the rat aorta, in the absence, but not in the presence of the endothelium.
Topics: Animals; Aorta, Thoracic; Calcium; Diltiazem; Endothelium, Vascular; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroprusside; Norepinephrine; Oxyhemoglobins; Rats; Rats, Inbred WKY; Vasoconstriction; Verapamil | 1991 |
Doxofylline differs from methylxanthines in its movement of cytosolic calcium.
Topics: Aminophylline; Animals; Binding Sites; Blood Platelets; Calcium; Cytosol; Diltiazem; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Theophylline; Verapamil | 1991 |
Inhibition by calcium channel blockers of the binding of platelet-activating factor to human neutrophil granulocytes.
Topics: Binding, Competitive; Calcium Channel Blockers; Cytoplasmic Granules; Diltiazem; Granulocytes; Humans; In Vitro Techniques; Indicators and Reagents; Kinetics; Neutrophils; Platelet Activating Factor; Superoxides; Verapamil | 1990 |
[Progress in the treatment of myocardial diseases].
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Captopril; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Diltiazem; Echocardiography; Electrocardiography; Female; Humans; Male; Middle Aged; Verapamil | 1990 |
Renal hemodynamic effects of calcium antagonists in rats with reduced renal mass.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Glomerular Filtration Rate; Hemodynamics; Homeostasis; Kidney; Male; Nifedipine; Rats; Rats, Inbred Strains; Renal Circulation; Verapamil | 1991 |
[Calcium antagonists in cardiomyopathy].
Topics: Calcium Channel Blockers; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Coronary Circulation; Diltiazem; Humans; Prognosis; Ventricular Function, Left; Verapamil | 1991 |
Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin.
Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Carbamazepine; Diltiazem; Drug Interactions; Female; Humans; Male; Middle Aged; Nifedipine; Phenytoin; Retrospective Studies; Seizures; Verapamil | 1991 |
Effect of diltiazem, nifedipine and verapamil on the antinociceptive action of acetylsalicylic acid in mice.
Topics: Analgesics; Animals; Aspirin; Benzoquinones; Diltiazem; Drug Interactions; Male; Mice; Nifedipine; Pain; Reaction Time; Verapamil | 1991 |
Heterogeneous interference of nicardipine, verapamil, and diltiazem with forearm arteriolar responsiveness to adrenergic stimulation in hypertensive patients.
Topics: Arterioles; Diltiazem; Female; Forearm; Humans; Hypertension; Lower Body Negative Pressure; Male; Nicardipine; Norepinephrine; Propranolol; Regional Blood Flow; Vasoconstriction; Vasodilation; Verapamil | 1991 |
Experimental hyperreflexia: effect of intravesical administration of various agents.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Diltiazem; Electric Stimulation; Electromyography; Hexamethonium Compounds; Male; Muscle Contraction; Nifedipine; Pyrroles; Rabbits; Reflex; Urinary Bladder Diseases; Vasodilator Agents; Verapamil | 1991 |
Influence of calcium channel blockers on polymorphonuclear and monocyte bactericidal and fungicidal activity.
Topics: Adult; Blood Bactericidal Activity; Calcium Channel Blockers; Candida albicans; Diltiazem; Escherichia coli; Fungi; Humans; Monocytes; Neutrophils; Nifedipine; Staphylococcus aureus; Time Factors; Verapamil | 1991 |
Calcium channel blockers and behavioral sensitization.
Topics: Amphetamine; Animals; Calcium Channel Blockers; Diltiazem; Haloperidol; Male; Mice; Nifedipine; Stereotyped Behavior; Verapamil | 1991 |
[Cardil (diltiazem) in the treatment of patients with ischemic heart disease and hypertension].
Topics: Coronary Disease; Diltiazem; Drug Evaluation; Hemodynamics; Humans; Hypertension; Nifedipine; Verapamil | 1990 |
Interactions of verapamil and diltiazem with ketamine: effects on memory and sleeping time in mice.
Topics: Animals; Avoidance Learning; Diltiazem; Drug Interactions; Ketamine; Male; Memory; Mice; Sleep; Verapamil | 1990 |
Antiischemic effect of trimetazidine: enzymatic and electric response in a model of in-vitro myocardial ischemia.
Topics: Animals; Cell Survival; Coronary Disease; Creatine Kinase; Diltiazem; Glyoxylates; Guinea Pigs; In Vitro Techniques; Pyridoxine; Trimetazidine; Verapamil | 1990 |
Protective effects of calcium channel blockers on hydrogen peroxide induced increases in endothelial permeability.
Topics: Albumins; Calcium Channel Blockers; Capillary Permeability; Cell Membrane Permeability; Cells, Cultured; Diltiazem; Electric Conductivity; Endothelium, Vascular; Humans; Hydrogen Peroxide; Nicardipine; Nifedipine; Verapamil | 1990 |
Tissue selectivity of the novel calcium antagonist sesamodil fumarate in isolated smooth muscles and cardiac muscles.
Topics: Animals; Calcimycin; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Heart; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nifedipine; Rabbits; Swine; Thiazoles; Verapamil | 1990 |
Inhibitory effects of endothelial cells and calcium channel blockers on platelet aggregation.
Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Bone Marrow Cells; Calcium Channel Blockers; Collagen; Diltiazem; Endothelium, Vascular; Epoprostenol; Fibroblasts; Humans; Nicardipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Verapamil | 1990 |
Concanavalin A- and fetal-calf-serum-induced rounding and myosin light chain phosphorylation in cultured smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blood; Calcimycin; Calcium; Cells, Cultured; Chickens; Concanavalin A; Culture Media; Cytochalasin B; Cytochalasins; Diltiazem; Egtazic Acid; Gizzard, Avian; Ionomycin; Isoquinolines; Kinetics; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Subfragments; Phosphorylation; Rabbits; Verapamil | 1990 |
Liver monooxygenase activity after multiple application of nifedipin, verapamil and diltiazem.
Topics: Androstenedione; Animals; Calcium Channel Blockers; Diltiazem; Hexobarbital; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Nifedipine; Rats; Rats, Inbred Strains; Sleep; Verapamil | 1990 |
Some calcium channel antagonists have no effect on the open-field behavior of rats nor do they interact with cocaine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Diltiazem; Drug Interactions; Male; Motor Activity; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Effect of calcium channel blockers on serotonin uptake.
Topics: Animals; Calcium Channel Blockers; Cattle; Cells, Cultured; Diltiazem; Endothelium; Endothelium, Vascular; Lung; Male; Muscle, Smooth; Neurotransmitter Uptake Inhibitors; Nifedipine; Organ Culture Techniques; Rats; Rats, Inbred Strains; Serotonin; Verapamil | 1990 |
Different negative inotropic activity of Ca2(+)-antagonists in human myocardial tissue.
Topics: Calcium Channel Blockers; Depression, Chemical; Diltiazem; Heart Atria; Heart Failure; Heart Transplantation; Humans; Isradipine; Myocardial Contraction; Nifedipine; Nitrendipine; Papillary Muscles; Pyridines; Verapamil | 1990 |
SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Indolizines; Isradipine; Male; Myocardium; Oxadiazoles; Phenethylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Sarcolemma; Verapamil | 1990 |
Inhibition of erythrocyte Ca2(+)-pump by Ca2+ antagonists.
Topics: Biological Transport, Active; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Erythrocytes; Humans; Verapamil | 1990 |
Additive effects of calcium antagonists on cyclosporin A-induced inhibition of T-cell proliferation.
Topics: Adult; Antibodies, Monoclonal; Calcium Channel Blockers; Cyclosporins; Diltiazem; Drug Synergism; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Nifedipine; Nimodipine; Phytohemagglutinins; T-Lymphocytes; Verapamil | 1990 |
Calcium channel receptor sites for (+)-[3H]PN 200-110 in coronary artery.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Coronary Vessels; Diltiazem; Edetic Acid; Female; In Vitro Techniques; Isradipine; Kinetics; Male; Oxadiazoles; Receptors, Nicotinic; Swine; Verapamil | 1990 |
Calcium-entry blockers during porcine cardiopulmonary resuscitation.
Topics: Animals; Blood Pressure; Diltiazem; Disease Models, Animal; Heart Arrest; Hydrogen-Ion Concentration; Myocardial Reperfusion Injury; Resuscitation; Swine; Verapamil | 1990 |
Mechanisms of gastric proton pump inhibition by calcium channel antagonists.
Topics: Adenosine Triphosphatases; Aminopyrine; Animals; Colforsin; Diltiazem; Gastric Acid; Gastric Mucosa; H(+)-K(+)-Exchanging ATPase; Microsomes; Oxygen Consumption; Parietal Cells, Gastric; Rabbits; Rana catesbeiana; Verapamil | 1990 |
Foridone and other calcium antagonists in the treatment of essential hypertension.
Topics: Antihypertensive Agents; Binding, Competitive; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Hypertension; Myocardium; Nifedipine; Receptors, Nicotinic; Verapamil | 1990 |
The preferential inhibition of alpha 1- over beta-adrenoceptor-mediated positive inotropic effect by organic calcium antagonists in the rabbit papillary muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Nifedipine; Papillary Muscles; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Subcellular Fractions; Verapamil | 1990 |
Attenuation of the low-density-lipoprotein-activated phosphoinositide signalling system by calcium blockers in human lymphocytes.
Topics: Calcium Channel Blockers; Cells, Cultured; Cholesterol, LDL; Diglycerides; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Humans; Lymphocytes; Molsidomine; Nifedipine; Phosphatidylinositols; Protein Kinase C; Verapamil | 1990 |
Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels. Evidence for an agonistic action.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Carps; Cell Membrane; Cerebral Cortex; Dihydropyridines; Diltiazem; Electric Conductivity; Guinea Pigs; Heparin; Isradipine; Molecular Sequence Data; Muscles; Myocardium; Nicotinic Antagonists; Oxadiazoles; Polyelectrolytes; Polymers; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1990 |
Actions of Ca2+ antagonists on two types of Ca2+ channels in rat aorta smooth muscle cells in primary culture.
Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Electric Conductivity; Flunarizine; Kinetics; Male; Membrane Potentials; Muscle, Smooth, Vascular; Nicardipine; Rats; Time Factors; Verapamil | 1990 |
Calcium entry blockers and oxiracetam have opposite effects on the density of dihydropyridine receptors in rat cerebral cortex.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Diltiazem; Dose-Response Relationship, Drug; Kinetics; Male; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Reference Values; Verapamil | 1990 |
Selective modulation by membrane potential of desmethoxyverapamil binding to calcium channels in rat portal vein.
Topics: Animals; Barium; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Isradipine; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Pyridines; Rats; Strontium; Verapamil | 1990 |
Chronic calcium antagonist use in carcinoma of the lung and colon: a retrospective cohort observational study.
Topics: Calcium; Carcinoma, Small Cell; Cohort Studies; Colonic Neoplasms; Diltiazem; Humans; Lung Neoplasms; Nifedipine; Retrospective Studies; Survival Analysis; Trifluoperazine; Verapamil | 1990 |
Role of guanine nucleotide binding protein, cytosolic calcium and cAMP in fluoride-induced suppression of PTH secretion.
Topics: Animals; Calcium; Cattle; Chlorides; Cyclic AMP; Cytosol; Diltiazem; GTP-Binding Proteins; Manganese; Manganese Compounds; Parathyroid Glands; Parathyroid Hormone; Pertussis Toxin; Second Messenger Systems; Sodium Fluoride; Verapamil; Virulence Factors, Bordetella | 1990 |
[3H]-nitrendipine binding in normal and cardiomyopathic hamster hearts: modulation by temperature, verapamil and diltiazem.
Topics: Allosteric Regulation; Animals; Binding Sites; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; Diltiazem; In Vitro Techniques; Kinetics; Male; Myocardium; Nitrendipine; Temperature; Verapamil | 1990 |
Bronchodilating effect of inhaled or orally administered calcium channel blocking agents on methacholine-induced bronchoconstriction.
Topics: Administration, Inhalation; Administration, Oral; Adolescent; Adult; Airway Resistance; Asthma; Bronchial Provocation Tests; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Male; Metaproterenol; Methacholine Chloride; Methacholine Compounds; Middle Aged; Nifedipine; Verapamil | 1990 |
Differential therapy with calcium antagonists in pulmonary hypertension secondary to COPD. Hemodynamic effects of nifedipine, diltiazem, and verapamil.
Topics: Calcium Channel Blockers; Diltiazem; Exercise Test; Hemodynamics; Humans; Hypertension, Pulmonary; Lung Diseases, Obstructive; Middle Aged; Nifedipine; Prospective Studies; Pulmonary Gas Exchange; Verapamil | 1990 |
Antidepressant-like action of nicardipine, verapamil and hemicholinium-3 injected into the anterior hypothalamus in the rat forced swim test.
Topics: Animals; Antidepressive Agents; Diltiazem; Hemicholinium 3; Hypothalamus, Anterior; Injections; Male; Motor Activity; Nicardipine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
A role for adenosine calcium and ischemia in radiocontrast-induced intrarenal vasoconstriction.
Topics: Acute Kidney Injury; Adenosine; Animals; Biological Transport, Active; Calcium; Contrast Media; Diatrizoate Meglumine; Diltiazem; Dogs; Female; Ischemia; Male; Renal Circulation; Sodium; Theophylline; Vasoconstriction; Verapamil | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximide; Male; Mice; Nifedipine; Pentylenetetrazole; Phenobarbital; Reference Values; Seizures; Valproic Acid; Verapamil | 1990 |
Calcium channel blockers increase norepinephrine concentrations in rat hypothalamus.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Analgesic effects of diltiazem and verapamil after central and peripheral administration in the hot-plate test.
Topics: Analgesics; Animals; Diltiazem; Drug Synergism; Female; Injections, Intraventricular; Injections, Subcutaneous; Mice; Morphine; Reaction Time; Verapamil | 1990 |
Uptake of catamphiphilic drugs into erythrocytes and muscular tissue correlates to membrane enrichment and to 45Ca displacement from phosphatidylserine monolayers.
Topics: Binding Sites; Calcium; Cell Membrane; Diltiazem; Erythrocytes; Flunarizine; Humans; In Vitro Techniques; Lidocaine; Muscles; Nitrendipine; Phosphatidylserines; Verapamil | 1990 |
Plasmodium chabaudi: in vivo effects of Ca2+ antagonists on chloroquine-resistant and chloroquine-sensitive parasites.
Topics: Animals; Calcium Channel Blockers; Chloroquine; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Female; Malaria; Mice; Mice, Inbred ICR; Nicardipine; Plasmodium; Verapamil | 1990 |
Reperfusion damage: free radicals mediate delayed membrane changes rather than early ventricular arrhythmias.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Calcium; Catalase; Diltiazem; Dose-Response Relationship, Drug; Free Radicals; Guinea Pigs; Heart; Heart Ventricles; Hydrogen Peroxide; In Vitro Techniques; Myocardial Reperfusion Injury; Oxygen; Rats; Superoxide Dismutase; Verapamil | 1990 |
[Effects of cardioplegic solution and calcium entry blockers on coronary artery contraction].
Topics: Animals; Calcium Channel Blockers; Cardioplegic Solutions; Coronary Vasospasm; Diltiazem; Dogs; Nicardipine; Nifedipine; Potassium; Potassium Compounds; Verapamil | 1990 |
Fluoride rapidly and transiently raises intracellular calcium in human osteoblasts.
Topics: Benzofurans; Calcium; Cells, Cultured; Cytosol; Diltiazem; Fluorescent Dyes; Fluorides; Fura-2; Humans; Nifedipine; Osteoblasts; Parathyroid Hormone; Time Factors; Verapamil | 1990 |
Effects of diltiazem, verapamil, and inhalation anesthetics on electrophysiologic properties affecting reentrant supraventricular tachycardia in chronically instrumented dogs.
Topics: Animals; Diltiazem; Dogs; Drug Interactions; Electrophysiology; Enflurane; Female; Halothane; Heart; Injections, Intravenous; Isoflurane; Male; Tachycardia, Supraventricular; Verapamil | 1990 |
Calcium channel blocker toxicity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Child; Child, Preschool; Delaware; Diltiazem; Female; Humans; Hypotension; Infant; Male; Middle Aged; Nervous System Diseases; Nifedipine; Pennsylvania; Poison Control Centers; Retrospective Studies; Verapamil | 1990 |
Effects of calcium channel blockers on the pharmacokinetics of propranolol stereoisomers.
Topics: Adult; Calcium Channel Blockers; Diltiazem; Humans; Male; Propranolol; Protein Binding; Stereoisomerism; Verapamil | 1990 |
Effects of various metals on hepatic bile calcium excretion in rats: the stimulatory effect of zinc is mediated through acetylcholine action.
Topics: Acetylcholine; Animals; Atropine; Bile; Calcium; Diltiazem; Homeostasis; Liver; Male; Rats; Rats, Inbred Strains; Verapamil; Zinc | 1990 |
Interaction between calcium channel blockers and volatile anaesthetics in the rat heart-lung preparation.
Topics: Anesthetics; Animals; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Interactions; Enflurane; Halothane; Heart; Heart Rate; Isoflurane; Male; Myocardial Reperfusion; Myocardium; Nifedipine; Rats; Rats, Inbred WKY; Verapamil | 1990 |
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
The effect of calcium antagonists on the activities of lipid metabolizing enzymes in the isolated ischaemically perfused and reperfused rat heart.
Topics: Acyltransferases; Animals; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Glycerol-3-Phosphate O-Acyltransferase; Heart; Lipase; Lipid Metabolism; Male; Myocardium; Nifedipine; Rats; Rats, Inbred Strains; Reperfusion Injury; Verapamil | 1990 |
Ca2+ and vasopressin release in isolated rat neurohypophysis: differential effects of four classes of Ca2+ channel ligands.
Topics: Animals; Calcium; Calcium Channel Blockers; Conotoxins; Diltiazem; Electric Stimulation; Male; Peptides, Cyclic; Pituitary Gland, Posterior; Rats; Rats, Inbred Strains; Vasopressins; Verapamil | 1990 |
Calcium channel blockers protect against ethylene glycol monomethyl ether (2-methoxyethanol)-induced testicular toxicity.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Ethylene Glycols; Male; Rats; Rats, Inbred F344; Testis; Verapamil | 1990 |
Effect of calcium antagonists on aortae isolated from normotensive and hypertensive rats: relaxation and calcium influx blockade.
Topics: Animals; Aorta; Calcium; Diltiazem; Female; Hypertension; In Vitro Techniques; Male; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Verapamil | 1990 |
Effects of calcium antagonists on biogenic amines in discrete brain areas.
Topics: Animals; Biogenic Monoamines; Brain Chemistry; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Electrochemistry; Flunarizine; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Adenosine potentiates the inhibitory effects of calcium channel antagonists on human platelet aggregation induced by thromboxane A2 or U46619.
Topics: Adenosine; Alprostadil; Calcium Channel Blockers; Diltiazem; Drug Synergism; Epinephrine; Humans; In Vitro Techniques; Nifedipine; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Verapamil | 1990 |
Effects of Ca antagonists on the norepinephrine release and contractile responses of isolated canine saphenous veins to high KCl.
Topics: 1-Methyl-3-isobutylxanthine; Anesthetics, Local; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Norepinephrine; Phentolamine; Potassium Chloride; Saphenous Vein; Verapamil | 1985 |
[Effect of substances modifying calcium movement on the contractility of cultured cardiac cells].
Topics: Animals; Caffeine; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Histamine; Imipramine; Ion Channels; Isoproterenol; Myocardial Contraction; Nifedipine; Phenylephrine; Rats; Verapamil | 1985 |
Mechanism of inhibition of net ion transport across frog corneal epithelium by calcium channel antagonists.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bepridil; Calcimycin; Calcium Channel Blockers; Cornea; Cyclic AMP; Diltiazem; Electric Conductivity; Epithelium; In Vitro Techniques; Ion Channels; Isoproterenol; Kinetics; Pyrrolidines; Rana catesbeiana; Sodium-Potassium-Exchanging ATPase; Verapamil | 1985 |
Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists.
Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Cinnarizine; Diltiazem; Flunarizine; Ion Channels; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Phenytoin; Pheochromocytoma; Potassium; Rats; Sodium; Verapamil | 1985 |
D600 as a direct blocker of Ca-dependent K currents in Helix neurons.
Topics: Animals; Cadmium; Calcium Channel Blockers; Diltiazem; Gallopamil; Helix, Snails; In Vitro Techniques; Ion Channels; Membrane Potentials; Neuromuscular Depolarizing Agents; Neurons; Verapamil | 1985 |
Inhibition of rabbit platelet phosphodiesterase activity and aggregation by calcium channel blockers.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenosine Diphosphate; Animals; Blood Platelets; Calcium Channel Blockers; Cytosol; Diltiazem; Kinetics; Nifedipine; Platelet Aggregation; Rabbits; Structure-Activity Relationship; Verapamil | 1985 |
[Inhibition of mastocyte granulation by 2 calcium antagonists: verapamil and diltiazem].
Topics: Animals; Benzazepines; Diltiazem; Histamine Release; Mast Cells; Mesentery; Rats; Rats, Inbred Strains; Verapamil | 1985 |
Effect of calcium antagonist drugs on calcium currents in mammalian skeletal muscle fibers.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channels; Muscles; Nifedipine; Nitrendipine; Rabbits; Verapamil | 1986 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Inotropic effects of Ca2+ channel agonist and antagonists in neuraminidase-treated left atria of rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Female; Heart Atria; In Vitro Techniques; Ion Channels; Isoproterenol; Male; Myocardial Contraction; N-Acetylneuraminic Acid; Neuraminidase; Nifedipine; Rats; Sialic Acids; Verapamil | 1986 |
Effects of calcium channel blockers on ouabain-induced oscillatory afterpotentials in organ-cultured young embryonic chick hearts.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Chick Embryo; Diltiazem; Ion Channels; Nifedipine; Organ Culture Techniques; Ouabain; Pyrrolidines; Verapamil | 1986 |
Two different presynaptic calcium currents in mouse motor nerve terminals.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Barium; Cadmium; Calcium; Diltiazem; In Vitro Techniques; Ion Channels; Kinetics; Manganese; Mice; Motor Neurons; Neuromuscular Junction; Potassium; Strontium; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1986 |
Differences in the actions of organic and inorganic Ca2+-antagonists on the inactivation of the Ca2+ channel in a molluscan neurone.
Topics: Animals; Cadmium; Calcium Channel Blockers; Cobalt; Diltiazem; In Vitro Techniques; Ion Channels; Membrane Potentials; Mollusca; Neurons; Verapamil | 1986 |
Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles. Characterization of diltiazem-binding sites and their interaction with dihydropyridine and aralkylamine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Diltiazem; Dithiothreitol; Ethylmaleimide; Female; Guinea Pigs; Hydrogen-Ion Concentration; Iodocyanopindolol; Male; Myocardium; Nifedipine; Nitrendipine; Ouabain; Pindolol; Receptors, Nicotinic; Sodium; Sodium-Potassium-Exchanging ATPase; Stereoisomerism; Temperature; Verapamil | 1986 |
[Effects of a new 1,4-dihydropyridine, Bay K 8644, on smooth muscle organs isolated from the guinea pig].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Verapamil | 1986 |
Effect of calcium antagonists on histamine release from human basophil leukocytes.
Topics: Adult; Basophils; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Gallopamil; Histamine Release; Humans; In Vitro Techniques; Verapamil | 1986 |
Effects of Ca2+ channel blockers on Ca2+ translocation across synaptosomal membranes.
Topics: Adenosine Triphosphatases; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Ion Channels; Nifedipine; Nimodipine; Sheep; Subcellular Fractions; Synaptic Membranes; Synaptosomes; Verapamil | 1986 |
Do calcium antagonists act directly on calcium channels to alter baroreceptor function?
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Nifedipine; Nimodipine; Nitrendipine; Pressoreceptors; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil | 1986 |
The relationship between the binding site of [3H]-d-cis-diltiazem and that of other non-dihydropyridine calcium entry blockers in cardiac sarcolemma.
Topics: Allosteric Regulation; Animals; Bepridil; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Diltiazem; Dogs; In Vitro Techniques; Ion Channels; Kinetics; Pyrrolidines; Sarcolemma; Verapamil | 1987 |
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma; Cell Line; Diltiazem; Drug Resistance; Glycoproteins; Humans; Nitrendipine; Quinidine; Verapamil; Vinblastine | 1987 |
Partial characterization of two (Ca+2 + Mg+2)-dependent ATPase activities from bovine brain synaptic membrane homogenates.
Topics: Animals; Brain; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Calmodulin; Cattle; Diltiazem; Hot Temperature; Ion Channels; Isoenzymes; Kinetics; Synaptic Membranes; Verapamil | 1987 |
Aggression and defeat-induced opioid analgesia displayed by mice are modified by calcium channel antagonists and agonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Animals; Calcium Channel Blockers; Diltiazem; Mice; Nifedipine; Pain; Reaction Time; Verapamil | 1987 |
[3H]BAY K 8644, a 1,4-dihydropyridine Ca++ channel activator: characteristics of binding to high and low affinity sites in cardiac membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Diltiazem; Edetic Acid; Female; Heart Ventricles; Hot Temperature; Kinetics; Lipolysis; Mathematics; Membranes; Myocardium; Nitrendipine; Propylamines; Rabbits; Tiapamil Hydrochloride; Verapamil | 1987 |
Ethanol-induced component of 45Ca2+ uptake in PC12 cells is sensitive to Ca2+ channel modulating drugs.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Cell Line; Diltiazem; Drug Interactions; Ethanol; Flunarizine; Ion Channels; Nifedipine; Verapamil | 1987 |
Calcium antagonist properties of diclofurime isomers. II. Molecular aspects: allosteric interactions with dihydropyridine recognition sites.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry, Physical; Diltiazem; In Vitro Techniques; Kinetics; Male; Nitrendipine; Oximes; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Stereoisomerism; Temperature; Verapamil | 1987 |
Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Diltiazem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immobilization; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Nifedipine; Pain; Reaction Time; Stress, Physiological; Verapamil | 1987 |
Blocking actions of Ca2+ antagonists on the Ca2+ channels in the smooth muscle cell membrane of rabbit small intestine.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Intestine, Small; Ion Channels; Muscle, Smooth; Nicardipine; Rabbits; Verapamil | 1987 |
Mediation of "calcium antagonist" effects by dopamine receptor blockade.
Topics: Bipolar Disorder; Diltiazem; Humans; Ion Channels; Receptors, Dopamine; Verapamil | 1987 |
Vascular versus myocardial selectivity of calcium antagonists studied by concentration-time-effect relations.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Felodipine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nitrendipine; Papillary Muscles; Rats; Rats, Inbred Strains; Time Factors; Verapamil | 1987 |
Effect of the calcium-channel blockers on calcium accumulation in sarcoplasmic reticulum of skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Arsenazo III; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Female; Ion Channels; Muscles; Rabbits; Sarcoplasmic Reticulum; Tetraphenylborate; Verapamil | 1987 |
Effects of Ca2+ agonist and antagonists on cytosolic free Ca2+ concentration: studies on Ca2+ channels in rat parotid cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Ion Channels; Kinetics; Male; Methoxamine; Nicardipine; Parotid Gland; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1987 |
Voltage-dependent cooperative interactions of calcium channel ligands in intact cardiac cells.
Topics: Allosteric Site; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Ion Channels; Kinetics; Membrane Potentials; Myocardium; Nicotinic Acids; Oxadiazoles; Rats; Verapamil | 1987 |
Inhibition of calcium channels in neuroblastoma x glioma hybrid cells by verapamil, D600, diltiazem and nisoldipine.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Glioma; Ion Channels; Neuroblastoma; Neurons; Nifedipine; Nisoldipine; Tumor Cells, Cultured; Verapamil | 1987 |
Dihydropyridine binding sites regulate calcium influx through specific voltage-sensitive calcium channels in cerebellar granule cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Cations, Divalent; Cell Membrane; Cells, Cultured; Cerebellum; Diltiazem; Electrophysiology; Ion Channels; Neurons; Nifedipine; Nitrendipine; Potassium; Rats; Receptors, Nicotinic; Verapamil | 1988 |
Magnetic fields inhibit opioid-mediated 'analgesic' behaviours of the terrestrial snail, Cepaea nemoralis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Diltiazem; Ion Channels; Magnetics; Morphine; Naloxone; Nifedipine; Nociceptors; Pyrrolidines; Snails; Temperature; Verapamil | 1988 |
Investigation of the mechanism of negative inotropic activity of some calcium antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anti-Arrhythmia Agents; Bepridil; Calcimycin; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Female; Flunarizine; Guinea Pigs; In Vitro Techniques; Lidoflazine; Male; Myocardial Contraction; Pyrrolidines; Verapamil | 1988 |
The effects of calcium channel blockers on isoproterenol induced cyclic adenosine 3',5'-monophosphate generation in intact human lymphocytes.
Topics: 1-Methyl-3-isobutylxanthine; Calcium Channel Blockers; Cyclic AMP; Diltiazem; Drug Synergism; Humans; Isoproterenol; Kinetics; Lanthanum; Lymphocytes; Nifedipine; Phenothiazines; Verapamil | 1988 |
Histamine stimulated synaptosomal Ca2+ uptake through activation of calcium channels.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Bucladesine; Calcium; Cinnarizine; Cyclic AMP; Diltiazem; Flunarizine; Histamine; Ion Channels; Nifedipine; Rats; Synaptosomes; Verapamil | 1988 |
Effect of calcium channel modulators on isolated endothelial cells.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Biological Products; Bradykinin; Calcium; Carbachol; Cattle; Diltiazem; Endothelium; Fura-2; Ion Channels; Isradipine; Nitric Oxide; Oxadiazoles; Thrombin; Verapamil | 1988 |
Potential-dependent allosteric modulation of 1,4-dihydropyridine binding by d-(cis)-diltiazem and (+/-)-verapamil in living cardiac cells.
Topics: Allosteric Regulation; Animals; Calcium; Diltiazem; Heart; In Vitro Techniques; Ion Channels; Isradipine; Membrane Potentials; Myocardium; Oxadiazoles; Rats; Sarcolemma; Verapamil | 1988 |
Differential effects of verapamil, nicardipine and diltiazem on Ca2+-dependent and Ca2+-independent noradrenaline release and contraction in isolated canine saphenous veins.
Topics: Animals; Calcium; Diltiazem; Dogs; Female; In Vitro Techniques; Ion Channels; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Norepinephrine; Saphenous Vein; Tetracaine; Tetraethylammonium Compounds; Verapamil | 1988 |
Studies on the site of the interaction between alpha 1-adrenoceptors and 5-HT2 receptors in rat tail arteries.
Topics: Animals; Arteries; Binding Sites; Diltiazem; Felodipine; In Vitro Techniques; Male; Manganese; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Tail; Verapamil | 1988 |
The effects of calcium channel agonists and antagonists on the release of endogenous glutamate from cerebellar slices.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcimycin; Calcium Channel Blockers; Calcium Channels; Cerebellum; Diltiazem; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1988 |
Fast-slow type of atrioventricular nodal reentrant tachycardia: horizontal dissociation of the AV node during tachycardia.
Topics: Adenosine Triphosphate; Aged; Atrioventricular Node; Cardiac Pacing, Artificial; Diltiazem; Heart Conduction System; Humans; Male; Middle Aged; Tachycardia, Supraventricular; Verapamil | 1988 |
Cyclosporine-A transport in isolated renal proximal tubular cells: inhibition by calcium channel blockers.
Topics: Animals; Biological Transport; Calcimycin; Calcium Channel Blockers; Cyclosporins; Diltiazem; Kidney Tubules, Proximal; Kinetics; Rabbits; Ruthenium Red; Trifluoperazine; Verapamil | 1988 |
Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Ethanol; Female; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Rats; Rats, Inbred Strains; Stereoisomerism; Substance Withdrawal Syndrome; Verapamil | 1988 |
Effect of verapamil on platelet aggregation.
Topics: Adenosine Diphosphate; Collagen; Cyproheptadine; Diltiazem; Epinephrine; Humans; In Vitro Techniques; Platelet Aggregation; Serotonin; Verapamil | 1988 |
Electromechanical effects of protamine in isolated human atrial and canine ventricular tissues.
Topics: Action Potentials; Animals; Calcium; Diltiazem; Dogs; Female; Heart; Histamine Release; Humans; In Vitro Techniques; Male; Myocardial Contraction; Potassium; Protamines; Purkinje Fibers; Verapamil | 1989 |
Two calcium channels in basolateral membranes of rabbit ileal epithelial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chlorides; Diltiazem; Egtazic Acid; Electric Conductivity; Epithelium; Ileum; Male; Nifedipine; Nitrendipine; Rabbits; Sodium; Verapamil | 1989 |
Dissociation of cardiodepression from cardioprotection with calcium antagonists: diltiazem protects ischemic rat myocardium with a lower functional cost as compared with verapamil or nifedipine.
Topics: Animals; Calcium; Calcium Chloride; Coronary Circulation; Coronary Disease; Diltiazem; Heart; Heart Function Tests; Heart Rate; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1989 |
The effects of human parathyroid hormone-related peptide on cytosolic free calcium and cAMP production in opossum kidney cell.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cell Line; Cyclic AMP; Cytosol; Diltiazem; Kidney; Neoplasm Proteins; Opossums; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptide Fragments; Proteins; Teriparatide; Verapamil | 1989 |
Effect of calcium-channel blockers and salbutamol on the isolated mare uterus--interaction with the calcium agonist Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Albuterol; Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Female; Horses; Nifedipine; Uterine Contraction; Uterus; Verapamil | 1989 |
Nicardipine inhibits axon conduction but causes dual changes of acetylcholine release in the mouse motor nerve.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Action Potentials; Animals; Axonal Transport; Axons; Chick Embryo; Diaphragm; Diltiazem; Female; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Motor Neurons; Muscle Contraction; Nicardipine; Nifedipine; Sodium Channels; Succinylcholine; Verapamil | 1989 |
[The effects of calcium channel blockers on the frequency and amplitude of the spontaneous contractions and the responses to acetylcholine on isolated rat duodenum].
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Diltiazem; Duodenum; Gastrointestinal Motility; Nifedipine; Rats; Verapamil | 1989 |
Treatment of reperfusion injury with intracoronary calcium channel antagonists and reduced coronary free calcium concentration in regionally ischemic, reperfused porcine hearts.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Egtazic Acid; Female; Infusions, Intra-Arterial; Male; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Nifedipine; Swine; Verapamil | 1989 |
Follicle-stimulating hormone-induced lactate secretion by cultured Sertoli cells does not require extracellular calcium.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Follicle Stimulating Hormone; Kinetics; Lactates; Male; Nifedipine; Rats; Rats, Inbred Strains; Sertoli Cells; Verapamil | 1989 |
Cutaneous adverse reactions associated with calcium channel blockers.
Topics: Adult; Aged; Aged, 80 and over; Calcium Channel Blockers; Diltiazem; Drug Eruptions; Humans; Middle Aged; Skin Diseases, Vesiculobullous; Verapamil | 1989 |
Verapamil is a potent inhibitor of 5-HT-induced platelet aggregation.
Topics: Adenosine Diphosphate; Amlodipine; Calcium Channel Blockers; Collagen; Diltiazem; Epinephrine; Humans; In Vitro Techniques; Nifedipine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin Antagonists; Verapamil | 1989 |
Calcium blockers: antiatherogenic action by influencing the prostaglandin-system.
Topics: Adult; Animals; Arteriosclerosis; Calcium Channel Blockers; Diltiazem; Epoprostenol; Female; Humans; In Vitro Techniques; Isradipine; Male; Malondialdehyde; Nifedipine; Platelet Aggregation; Prostaglandins; Pyridines; Rats; Rats, Inbred Strains; Verapamil | 1989 |
A hemodynamic comparison of verapamil, diltiazem, and amlodipine in coronary artery disease.
Topics: Amlodipine; Calcium Channel Blockers; Coronary Disease; Diltiazem; Female; Hemodynamics; Humans; Male; Middle Aged; Nifedipine; Physical Exertion; Rest; Verapamil | 1989 |
Effects of Ca++ on [3H]diltiazem binding and its allosteric interaction with dihydropyridine calcium channel binding sites in the rat cortex.
Topics: Allosteric Regulation; Animals; Binding Sites; Calcium; Calcium Channels; Cerebral Cortex; Diltiazem; In Vitro Techniques; Male; Nitrendipine; Rats; Rats, Inbred Strains; Temperature; Verapamil | 1989 |
Endothelin induces two types of contractions of rat uterus: phasic contractions by way of voltage-dependent calcium channels and developing contractions through a second type of calcium channels.
Topics: Animals; Binding, Competitive; Calcium; Calcium Channels; Diltiazem; Endothelins; Endothelium, Vascular; Female; Iodine Radioisotopes; Nifedipine; Oxytocin; Peptides; Rats; Rats, Inbred Strains; Uterine Contraction; Verapamil | 1989 |
The failure of endothelin to displace bound, radioactively-labelled, calcium antagonists (PN 200/110, D888 and diltiazem).
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endothelins; Female; In Vitro Techniques; Isradipine; Oxadiazoles; Peptides; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Verapamil | 1989 |
Distinction of two components of passive Ca2+ transport into human erythrocytes by Ca2+ entry blockers.
Topics: Aminoquinolines; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane Permeability; Cobalt; Copper; Diltiazem; Erythrocyte Membrane; Flunarizine; Humans; Nifedipine; Vanadates; Verapamil | 1989 |
[Calcium antagonists vs ACE inhibitors in the treatment of essential arterial hypertension in the aged].
Topics: Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diltiazem; Drug Evaluation; Enalapril; Female; Humans; Hypertension; Male; Nifedipine; Verapamil | 1989 |
Selective inhibition by nifedipine of the purinergic component of neurogenic vasoconstriction in the dog mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Diltiazem; Dogs; Electric Stimulation; In Vitro Techniques; Mesenteric Arteries; Nifedipine; Norepinephrine; Receptors, Adrenergic, alpha; Receptors, Purinergic; Vasoconstriction; Verapamil | 1989 |
Desmethoxyverapamil-sensitive calcium channels in rat portal vein smooth muscle.
Topics: Animals; Calcium Channels; Diltiazem; In Vitro Techniques; Membranes; Muscle, Smooth, Vascular; Nicardipine; Portal Vein; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Voltage dependent calcium channel expression in isolated osteoclasts.
Topics: Animals; Calcium Channels; Cell Membrane; Cells, Cultured; Chickens; Diltiazem; Electrophysiology; Female; Nicardipine; Osteoclasts; Potassium Chloride; Verapamil | 1989 |
Interference of prenatal and postnatal exposure to Ca2+-antagonist agents on rat functional development of vascular system.
Topics: Acetylcholinesterase; Animals; Animals, Newborn; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiovascular System; Catecholamines; Diltiazem; Dose-Response Relationship, Drug; Female; Gestational Age; Heart Rate; Male; N-Glycosyl Hydrolases; Nimodipine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Vasomotor System; Verapamil | 1989 |
Pharmacological characterization of mare uterus motility with special reference to calcium antagonists and beta-2-adrenergic stimulants.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Calcium Channel Blockers; Culture Media; Cyclic AMP; Diltiazem; Female; Hexoprenaline; Horses; In Vitro Techniques; Indomethacin; Myometrium; Nifedipine; Tetrodotoxin; Uterine Contraction; Verapamil | 1989 |
Modification of tumour response by calcium antagonists in the SCVII/St tumour implanted at two different sites.
Topics: Animals; Back; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flunarizine; Hindlimb; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nifedipine; Radiation Tolerance; Rubidium; Verapamil | 1989 |
Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; Heart; Ion Channels; Isoquinolines; Male; Myocardial Contraction; Nifedipine; Nitrendipine; Receptors, GABA-A; Tetraethylammonium Compounds; Verapamil | 1985 |
Molecular approach to the calcium channel.
Topics: Animals; Benzothiazoles; Binding Sites; Brain; Calcium; Cattle; Chemical Phenomena; Chemistry; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles; Thiazoles; Verapamil | 1985 |
Differential antagonism by Bay k 8644, a dihydropyridine calcium agonist, of the negative inotropic effects of nifedipine, verapamil, diltiazem and manganese ions in canine ventricular muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart; In Vitro Techniques; Male; Manganese; Myocardial Contraction; Nifedipine; Verapamil | 1985 |
A role for calcium in radiocontrast-induced reductions in renal hemodynamics.
Topics: Animals; Blood Pressure; Calcium; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Diltiazem; Dogs; Egtazic Acid; Female; Glomerular Filtration Rate; Ion Channels; Kidney; Male; Renal Circulation; Vasoconstriction; Verapamil | 1985 |
[Classification of Ca antagonist by its chemical structure and characteristics of each derivative].
Topics: Calcium Channel Blockers; Chemical Phenomena; Chemistry; Dihydropyridines; Diltiazem; Drug Interactions; Humans; Membrane Potentials; Structure-Activity Relationship; Verapamil | 1989 |
[Calcium antagonists in the treatment of hypertension].
Topics: Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Nicardipine; Nifedipine; Verapamil | 1989 |
[Treatment of cardiomyopathy using Ca blockers].
Topics: Animals; Calcium Channel Blockers; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Cricetinae; Diltiazem; Disease Models, Animal; Humans; Mesocricetus; Nifedipine; Verapamil | 1989 |
Effects of hypoxia, elevated K+ and acidosis on the potency of verapamil, diltiazem and nifedipine in the guinea-pig isolated papillary muscle.
Topics: Acidosis; Animals; Cell Hypoxia; Coronary Disease; Diltiazem; Dinitrophenols; Electric Stimulation; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Nifedipine; Papillary Muscles; Potassium; Verapamil | 1989 |
[The use of calcium antagonists for treating hypertension].
Topics: Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Nifedipine; Verapamil | 1989 |
Effect of extracellular calcium and calcium channel antagonists on ATP and field stimulation induced contractions of the mouse urinary bladder.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Electric Stimulation; Male; Mice; Muscle Contraction; Muscle, Smooth; Nifedipine; Urinary Bladder; Verapamil | 1989 |
Inhibitory effects of calcium channel blockers on intestinal motility in the dog.
Topics: Animals; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Dogs; Gastrointestinal Motility; Nifedipine; Software; Verapamil | 1989 |
Electrophysiological effects of bepridil and its quaternary derivative CERM 11888 in closed chest anaesthetized dogs: a comparison with verapamil and diltiazem.
Topics: Anesthesia; Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Sinoatrial Node; Time Factors; Verapamil | 1989 |
Effect of diltiazem, verapamil and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible human skeletal muscle.
Topics: Caffeine; Dantrolene; Diltiazem; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Verapamil | 1989 |
The differential effect of calcium antagonists on the positive inotropic effects induced by calcium and monensin in cardiac preparations of rats and guinea-pigs.
Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Diltiazem; Gallic Acid; Heart Ventricles; Lidoflazine; Male; Monensin; Myocardial Contraction; Nifedipine; Papillary Muscles; Rats; Rats, Inbred Strains; Ryanodine; Stimulation, Chemical; Verapamil | 1989 |
Endothelium-derived relaxing factor(s) and calcium antagonists.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Endothelium, Vascular; Male; Muscle, Smooth, Vascular; Nitric Oxide; Norepinephrine; Rats; Rats, Inbred Strains; Vasoconstriction; Verapamil | 1989 |
Hatching of Schistosoma mansoni eggs is a Ca2+/calmodulin-dependent process.
Topics: Animals; Calcium; Calmodulin; Diltiazem; Schistosoma mansoni; Sulfonamides; Verapamil; Zygote | 1989 |
Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists.
Topics: Calcium Channel Blockers; Chemotactic Factors; Chemotaxis, Leukocyte; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Interleukin-1; Interleukin-8; Interleukins; Kinetics; Lymphocytes; Nifedipine; Recombinant Proteins; Verapamil | 1989 |
Variable, voltage-dependent, blocking effects of nitrendipine, verapamil, diltiazem, cinnarizine and cadmium on adrenomedullary secretion.
Topics: Adrenal Medulla; Animals; Cadmium; Calcium Channel Blockers; Catecholamines; Cats; Cinnarizine; Diltiazem; Electric Stimulation; In Vitro Techniques; Nitrendipine; Verapamil | 1989 |
In vivo characterization of combination antitumor chemotherapy with calcium channel blockers and cis-diamminedichloroplatinum(II).
Topics: Animals; Calcium Channel Blockers; Cisplatin; Diltiazem; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Imidazoles; Lung Neoplasms; Melanoma, Experimental; Mice; Nicardipine; Nifedipine; Trifluoperazine; Verapamil | 1989 |
Differential susceptibility of cholinergic and noncholinergic neurogenic responses to calcium channel blockers and low Ca2+ medium in rat urinary bladder.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Autonomic Nervous System; Calcium; Calcium Channel Blockers; Diltiazem; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Neural Pathways; Neurons; Parasympathetic Nervous System; Rats; Urinary Bladder; Verapamil | 1989 |
Effects of ketanserin, verapamil and diltiazem on vascular sympathetic nerve activity in hypertension.
Topics: Animals; Blood Pressure; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Ketanserin; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System; Verapamil | 1989 |
Effects of calcium entry blockers on human platelet metabolism measured by microcalorimetry.
Topics: Blood Platelets; Calcium Channel Blockers; Calorimetry; Cerebral Arteries; Diltiazem; Flunarizine; Humans; Muscle Relaxation; Nifedipine; Verapamil | 1989 |
Effects of calcium channel blockers on in vitro platelet function in whole blood using single platelet counting.
Topics: Adult; Calcium Channel Blockers; Collagen; Diltiazem; Epinephrine; Female; Humans; In Vitro Techniques; Male; Nifedipine; Nimodipine; Platelet Aggregation Inhibitors; Platelet Count; Verapamil | 1989 |
Cataract formation is prevented by administration of verapamil to diabetic rats.
Topics: Animals; Calcium; Cataract; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diltiazem; Injections; Lens, Crystalline; Lipids; Male; Microcirculation; Rats; Rats, Inbred Strains; Retina; Verapamil | 1989 |
Sources of calcium for ATP-induced contractions in rat urinary bladder smooth muscle.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Radioisotopes; Diltiazem; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Urinary Bladder; Verapamil | 1989 |
Reperfusion-induced arrhythmias in the conscious rat: a comparative study with three calcium antagonists.
Topics: Animals; Arrhythmias, Cardiac; Consciousness; Coronary Disease; Diltiazem; Electrocardiography; Heart Rate; Male; Myocardial Reperfusion Injury; Nifedipine; Rats; Rats, Inbred Strains; Tachycardia; Ventricular Fibrillation; Verapamil | 1989 |
Teratogenic effects of some calcium channel blocking agents in Xenopus embryos.
Topics: Abnormalities, Drug-Induced; Animals; Calcium Channel Blockers; Diltiazem; Nicardipine; Verapamil; Xenopus | 1989 |
Potentiation of cocaine toxicity with calcium channel blockers.
Topics: Animals; Cocaine; Diltiazem; Drug Synergism; Injections, Intraperitoneal; Male; Nifedipine; Rats; Rats, Inbred Strains; Seizures; Verapamil | 1989 |
[The effect of the calcium antagonists nimodipin, verapamil and diltiazem on local cerebral blood flow of the cortex and thalamus in cats].
Topics: Animals; Cats; Cerebral Cortex; Diltiazem; Nimodipine; Regional Blood Flow; Thalamus; Verapamil | 1989 |
[The effect of calcium antagonists nimodipin, verapamil, diltiazem and flunarizin on local cerebral blood flow in rabbits in chronic experiments].
Topics: Animals; Cerebral Cortex; Diltiazem; Female; Flunarizine; Male; Nimodipine; Rabbits; Regional Blood Flow; Verapamil | 1989 |
Histamine-induced calcium transients in vascular smooth muscle cells: effects of verapamil and diltiazem.
Topics: Aminoquinolines; Animals; Aorta; Calcium; Cell Fractionation; Cells, Cultured; Centrifugation, Density Gradient; Cimetidine; Cytosol; Diltiazem; Fluorescent Dyes; Histamine; Kinetics; Male; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Pyrilamine; Rats; Rats, Inbred Strains; Sarcolemma; Swine; Verapamil | 1989 |
Diabetes enhances vasoreactivity to calcium entry blockers.
Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diltiazem; Heart; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Reference Values; Vascular Resistance; Verapamil | 1989 |
The effects of calcium channel blocking drugs on the thermotropic behavior of dimyristoylphosphatidylcholine.
Topics: Calcium Channel Blockers; Calorimetry, Differential Scanning; Diltiazem; Dimyristoylphosphatidylcholine; Models, Biological; Nifedipine; Nimodipine; Nisoldipine; Thermodynamics; Verapamil | 1989 |
Effects of calcium channel blockers and hydralazine on epinephrine-induced hyperglycemia in vivo.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Epinephrine; Food Deprivation; Glucose Tolerance Test; Hydralazine; Hyperglycemia; Male; Nicardipine; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Left ventricular pressure-diameter relations in the conscious rabbit.
Topics: Animals; Blood Pressure; Consciousness; Diltiazem; Heart; Heart Rate; Male; Methoxamine; Models, Biological; Myocardial Contraction; Nitroprusside; Norepinephrine; Rabbits; Verapamil | 1989 |
Relaxation of airway smooth muscle induced by potassium in the presence of Ca-antagonists.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Epithelium; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Potassium; Trachea; Verapamil | 1989 |
Role of theophylline, verapamil, and diltiazem on rat fatigued diaphragmatic muscle in vitro.
Topics: Animals; Diaphragm; Diltiazem; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Respiratory Muscles; Theophylline; Verapamil | 1989 |
Effects of verapamil, diltiazem and disopyramide on sinus function: a comparison with bepridil.
Topics: Animals; Bepridil; Diltiazem; Disopyramide; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Pyrrolidines; Rabbits; Sinoatrial Node; Verapamil | 1989 |
Calcium channel antagonists and cyclosporine metabolism: in vitro studies with human liver microsomes.
Topics: Adult; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cyclosporins; Diltiazem; Female; Humans; In Vitro Techniques; Male; Microsomes, Liver; Middle Aged; Nicardipine; Radioimmunoassay; Verapamil | 1989 |
[Incessant supraventricular tachycardia due to upper atrioventricular nodal reentry].
Topics: Adenosine Triphosphate; Aged; Diltiazem; Female; Humans; Male; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular; Verapamil | 1989 |
[Electrophysiologic effects of calcium channel blockers on supraventricular tachycardia in children].
Topics: Adolescent; Atrioventricular Node; Calcium Channel Blockers; Child; Child, Preschool; Diltiazem; Electrophysiology; Humans; Infant; Infant, Newborn; Male; Sinoatrial Node; Tachycardia, Supraventricular; Verapamil | 1989 |
[Study of the effects of calcium antagonists on respiration mechanics in patients with occlusive ventilation impairment].
Topics: Adult; Bronchial Spasm; Calcium Channel Blockers; Diltiazem; Female; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1989 |
Effects of calcium antagonists on alpha-adrenoceptor mediated vasoconstrictions of the canine intermediate auricular artery.
Topics: Animals; Arteries; Clonidine; Diltiazem; Dogs; Female; In Vitro Techniques; Male; Norepinephrine; Phenylephrine; Potassium Chloride; Receptors, Adrenergic, alpha; Skin; Vasoconstriction; Verapamil | 1987 |
Low affinity binding sites for 1,4-dihydropyridines in mitochondria and in guinea pig ventricular membranes.
Topics: Animals; Calcium Channels; Cations, Divalent; Cell Membrane; Diltiazem; Guinea Pigs; Heart Ventricles; Hot Temperature; Mitochondria; Myocardium; Nimodipine; Nitrendipine; Osmolar Concentration; Protein Denaturation; Receptors, Nicotinic; Sodium Chloride; Verapamil | 1987 |
Ca2+ channel blockers interact with alpha 2-adrenergic receptors in rabbit ileum.
Topics: Animals; Calcium Channel Blockers; Clonidine; Diltiazem; Egtazic Acid; Electrolytes; Ileum; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Membrane Potentials; Nifedipine; Rabbits; Receptors, Adrenergic, alpha; Verapamil; Yohimbine | 1988 |
Prostaglandin induces Ca2+ influx and cyclic GMP formation in mouse neuroblastoma X rat glioma hybrid NG108-15 cells in culture.
Topics: Aminoquinolines; Animals; Calcium; Cyclic GMP; Diltiazem; Dinoprost; Dinoprostone; Fluorescent Dyes; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Nifedipine; Potassium; Prostaglandin D2; Prostaglandins; Prostaglandins D; Prostaglandins E; Prostaglandins F; Rats; Tumor Cells, Cultured; Verapamil | 1988 |
Effects of calcium channel blockers on the respiration of HeLa cells and HeLa mitochondria and the generation of oxidising free radicals in tissues subject to calcium imbalance.
Topics: Animals; Cattle; Diltiazem; Female; Free Radicals; HeLa Cells; Humans; Kinetics; Luminescent Measurements; Lymphocytes; Mitochondria; Mitochondria, Heart; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Inbred Strains; Superoxides; Verapamil | 1988 |
The influence of calcium channel blockers on superoxide anions.
Topics: Animals; Anions; Calcium Channel Blockers; Diltiazem; Fendiline; Free Radicals; In Vitro Techniques; Microsomes, Liver; Nifedipine; Oxidation-Reduction; Rats; Superoxides; Verapamil; Xanthine Oxidase | 1988 |
Effects of calcium antagonists on membrane fluidity in hypertension--an electron spin resonance study.
Topics: Adult; Animals; Diltiazem; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Female; Humans; Hypertension; Male; Membrane Fluidity; Middle Aged; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Verapamil | 1988 |
Ca-entry blockers, verapamil and diltiazem, on alpha 1-adrenoceptors in thoracic aorta, renal artery and portal vein from rabbit.
Topics: Animals; Aorta, Thoracic; Diltiazem; Dose-Response Relationship, Drug; Male; Norepinephrine; Portal Vein; Rabbits; Receptors, Adrenergic, alpha; Renal Artery; Verapamil | 1988 |
Inotropic effect of thyrotropin-releasing hormone on the guinea pig myocardium.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Cimetidine; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Guinea Pigs; Kinetics; Manganese; Metoclopramide; Myocardial Contraction; Norepinephrine; Phentolamine; Potassium; Stimulation, Chemical; Thyrotropin-Releasing Hormone; Verapamil | 1988 |
Modulation of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by Ca2+ antagonists.
Topics: Adenosine Triphosphate; Alamethicin; Animals; Calcium; Calcium Channel Blockers; Digitoxigenin; Diltiazem; Dogs; Monensin; Nifedipine; Ouabain; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase; Verapamil | 1988 |
Effects of Ca-antagonists and antispasmodic drugs on contraction by ACh in molluscan smooth muscle.
Topics: Acetylcholine; Animals; Bivalvia; Calcium Channel Blockers; Diltiazem; Dimethylphenylpiperazinium Iodide; Drug Interactions; Gallopamil; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Papaverine; Parasympatholytics; Piperidines; Verapamil | 1985 |
Effect of verapamil and diltiazem on isolated gastro-oesophageal sphincter of the rat.
Topics: Animals; Benzazepines; Carbachol; Diltiazem; Esophagogastric Junction; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Rats; Verapamil | 1985 |
Cardiogenic shock associated with calcium-channel and beta blockers: reversal with intravenous calcium chloride.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Calcium Channel Blockers; Calcium Chloride; Digoxin; Diltiazem; Female; Humans; Isoproterenol; Male; Shock, Cardiogenic; Verapamil | 1985 |
Clinical and research applications of ambulatory Holter ST-segment and heart rate monitoring.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Angina Pectoris, Variant; Blood Pressure; Coronary Circulation; Coronary Disease; Diltiazem; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Monitoring, Physiologic; Myocardial Contraction; Nifedipine; Substance Withdrawal Syndrome; Time Factors; Verapamil | 1986 |
Use of drugs in cardiac rehabilitation.
Topics: Adrenergic beta-Antagonists; Amiodarone; Diltiazem; Drug Therapy, Combination; Electrocardiography; Exercise Test; Heart Diseases; Humans; Middle Aged; Nifedipine; Nitrates; Nitroglycerin; Physical Exertion; Verapamil | 1986 |
Verapamil, diltiazem and nifedipine inhibit vascular responses to noradrenaline, acetylcholine and 5-hydroxytryptamine in human saphenous vein.
Topics: Acetylcholine; Calcium Channel Blockers; Diltiazem; Humans; In Vitro Techniques; Male; Middle Aged; Muscle, Smooth, Vascular; Neurotransmitter Agents; Nifedipine; Norepinephrine; Saphenous Vein; Serotonin; Vasodilation; Verapamil | 1986 |
Evaluation of different drugs in two models of immediate hypersensitivity.
Topics: Animals; Cromolyn Sodium; Diethylcarbamazine; Diltiazem; Female; Guinea Pigs; Histamine H1 Antagonists; Hypersensitivity, Immediate; In Vitro Techniques; Isometric Contraction; Male; Nicardipine; Ovalbumin; Passive Cutaneous Anaphylaxis; Quinazolines; Trachea; Verapamil | 1988 |
Effects of some calcium antagonists on aggregation by adrenalin and serotonin and on alpha-adrenoceptor radioligand binding in human platelets.
Topics: Adrenergic alpha-Antagonists; Calcium Channel Blockers; Diltiazem; Epinephrine; Humans; Ketanserin; Nifedipine; Phentolamine; Platelet Aggregation; Radioligand Assay; Serotonin; Verapamil; Yohimbine | 1988 |
Diltiazem, verapamil, and nifedipine inhibit theophylline-enhanced diaphragmatic contractility.
Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Diaphragm; Diltiazem; Male; Muscle Contraction; Nifedipine; Rats; Rats, Inbred Strains; Theophylline; Verapamil | 1989 |
Effects of calcium channel blockers on in vivo cellular immunity in mice.
Topics: Animals; Calcium Channel Blockers; Cyclosporins; Dermatitis, Contact; Dexamethasone; Diltiazem; Ear, External; Ethanol; Female; Immunity, Cellular; Mice; Mice, Inbred C3H; Nifedipine; Verapamil | 1989 |
Effect of calcium channel blockers on hemodynamic responses to defibrillation.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Pacing, Artificial; Diltiazem; Dogs; Electric Countershock; Heart Conduction System; Heart Rate; Hemodynamics; Nifedipine; Ventricular Fibrillation; Verapamil | 1989 |
Characterization of volume-sensitive, calcium-permeating pathways in the osteosarcoma cell line UMR-106-01.
Topics: Calcium; Cell Membrane Permeability; Cytosol; Diltiazem; Electric Conductivity; Kinetics; Lanthanum; Membrane Potentials; Nicardipine; Osmolar Concentration; Osteoblasts; Osteosarcoma; Tumor Cells, Cultured; Valinomycin; Verapamil | 1989 |
Ca2+-channel blockers inhibit the action of recombinant platelet-derived growth factor in vascular smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Nifedipine; Platelet-Derived Growth Factor; Rabbits; Recombinant Proteins; Vasoconstriction; Verapamil | 1989 |
Cardioprotection by the calcium antagonist PN 200-110 in the absence and presence of cardiodepression.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; In Vitro Techniques; Isradipine; Myocardial Contraction; Myocardium; Oxadiazoles; Rabbits; Time Factors; Verapamil | 1985 |
[Effects of injectable calcium blockers on cardiac function and relaxation in left ventricular hypertrophy].
Topics: Adult; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiomegaly; Coronary Vessels; Diltiazem; Hemodynamics; Humans; Injections, Intra-Arterial; Injections, Intravenous; Middle Aged; Myocardial Contraction; Verapamil | 1985 |
[Vasorelaxing action of nicorandil, in comparison with nitroglycerin and Ca antagonists].
Topics: Animals; Aorta; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Drug Interactions; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil | 1986 |
Calcium channel antagonists. Omega-conotoxin defines a new high affinity site.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Chick Embryo; Cinnarizine; Diltiazem; Flunarizine; Muscles; Nifedipine; Nitrendipine; Prenylamine; Rana pipiens; Synaptosomes; Time Factors; Verapamil | 1986 |
The effects of some slow channel blocking drugs on high affinity serotonin uptake by rat brain synaptosomes.
Topics: Animals; Bepridil; Brain; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Pyrrolidines; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes; Temperature; Time Factors; Verapamil | 1986 |
A nimodipine-resistant Ca2+ pathway is involved in myogenic tone in a resistance artery.
Topics: Analysis of Variance; Animals; Arteries; Calcium; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Isradipine; Male; Manganese; Muscle, Smooth, Vascular; Nicotinic Acids; Nimodipine; Oxadiazoles; Potassium; Rabbits; Vascular Resistance; Verapamil | 1986 |
[Effects of trimetazidine on a model of in vitro myocardial ischemia].
Topics: Animals; Coronary Circulation; Coronary Disease; Creatine Kinase; Diltiazem; Electrocardiography; Guinea Pigs; Heart; In Vitro Techniques; Piperazines; Trimetazidine; Verapamil | 1986 |
Verapamil, diltiazem and nifedipine interactions with calmodulin stimulated (Ca2+ + Mg2+)-ATPase.
Topics: Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Calmodulin; Diltiazem; Drug Synergism; Enzyme Activation; Erythrocytes; Humans; Kinetics; Nifedipine; Verapamil | 1988 |
Assessment of hemodynamic function and tolerance to ischemia in the absence or presence of calcium antagonists in hearts of isoproterenol-treated, exercise-trained, and sedentary rats.
Topics: Animals; Cardiomegaly; Cardioplegic Solutions; Creatine Kinase; Diltiazem; Fibrosis; Heart Arrest, Induced; Hemodynamics; Isoproterenol; Myocardium; Organ Size; Physical Education and Training; Rats; Verapamil | 1988 |
Effect of membrane depolarization on binding of [3H]nitrendipine to rat cardiac myocytes.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Cell Survival; Diltiazem; Heart; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Myocardium; Nifedipine; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Verapamil | 1985 |
Characterization of the binding sites for nimodipine and (-)-desmethoxyverapamil in bovine cardiac sarcolemma.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Cattle; Diltiazem; Egtazic Acid; In Vitro Techniques; Kinetics; Myocardium; Nicotinic Acids; Nimodipine; Receptors, Nicotinic; Sarcolemma; Tritium; Verapamil | 1985 |
Similarities and differences in the effects of verapamil, diltiazem and nifedipine on arterial baroreflexes of anesthetized cats.
Topics: Anesthesia; Animals; Benzazepines; Blood Pressure; Carotid Arteries; Cats; Diltiazem; Electric Stimulation; Female; Heart Rate; Isoproterenol; Male; Nifedipine; Pressoreceptors; Receptors, Adrenergic, beta; Receptors, Muscarinic; Reflex; Vagotomy; Vagus Nerve; Verapamil | 1985 |
Modification of cardiac sarcolemmal Na+-Ca2+ exchange by diltiazem and verapamil.
Topics: Acebutolol; Animals; Benzazepines; Ca(2+) Mg(2+)-ATPase; Calcium; Diltiazem; In Vitro Techniques; Myocardium; Nifedipine; Nitrendipine; Propranolol; Rats; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase; Verapamil | 1985 |
Synaptic facilitation by 3-aminopyridine and its antagonism by verapamil and diltiazem.
Topics: 4-Aminopyridine; Action Potentials; Amifampridine; Aminopyridines; Animals; Benzazepines; Calcium; Diltiazem; Dose-Response Relationship, Drug; Rana catesbeiana; Synapses; Synaptic Transmission; Verapamil | 1985 |
Characterization of the Ca2+ coordination site regulating binding of Ca2+ channel inhibitors d-cis-diltiazem, (+/-)bepridil and (-)desmethoxyverapamil to their receptor site in skeletal muscle transverse tubule membranes.
Topics: Barium; Benzazepines; Bepridil; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Kinetics; Magnesium; Membranes; Microtubules; Muscles; Pyrrolidines; Receptors, Nicotinic; Strontium; Verapamil | 1985 |
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
Topics: Affinity Labels; Animals; Autoradiography; Benzazepines; Bepridil; Binding, Competitive; Calcium Channels; Diltiazem; Isradipine; Kinetics; Muscles; Oxadiazoles; Photochemistry; Pyrrolidines; Rabbits; Receptors, Nicotinic; Verapamil | 1986 |
Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockers in vitro.
Topics: Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Drug Synergism; Gallopamil; Male; Neuromuscular Junction; Nifedipine; Nisoldipine; Pancuronium; Rats; Rats, Inbred Strains; Synaptic Transmission; Verapamil | 1985 |
Calcium antagonists and low density lipoproteins metabolism by human fibroblasts and by human hepatoma cell line HEP G2.
Topics: Amanitins; Biotransformation; Calcium Channel Blockers; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Diltiazem; Fibroblasts; Humans; Lipoproteins; Lipoproteins, LDL; Liver Neoplasms; Papaverine; Receptors, LDL; Verapamil | 1986 |
Medical treatment for inoperable insulinoma: clinical usefulness of diphenylhydantoin and diltiazem.
Topics: Adenoma, Islet Cell; Aged; Benzazepines; Blood Glucose; C-Peptide; Celiac Artery; Diltiazem; Female; Humans; Insulin; Insulinoma; Pancreatic Neoplasms; Phenytoin; Propranolol; Radiography; Verapamil | 1986 |
High Ca2+ inhibits AVP-dependent cAMP production in thick ascending limbs of Henle.
Topics: Adenylyl Cyclases; Animals; Arginine Vasopressin; Biomechanical Phenomena; Calcimycin; Calcium; Colforsin; Cyclic AMP; Diltiazem; In Vitro Techniques; Kidney Tubules; Kidney Tubules, Collecting; Loop of Henle; Male; Mice; Mice, Inbred ICR; Time Factors; Verapamil | 1986 |
Role of sodium-calcium exchange and effects of calcium entry blockers on endothelial-mediated responses in rat isolated aorta.
Topics: Amiloride; Animals; Aorta; Bepridil; Calcium; Calcium Channel Blockers; Choline; Cyclic GMP; Diltiazem; Endothelium; Female; Lithium; Muscle, Smooth, Vascular; Nicergoline; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Reserpine; Sodium; Verapamil | 1986 |
The effect of beta-adrenergic blockade on the cardiovascular response to diltiazem or verapamil in dogs.
Topics: Animals; Catecholamines; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Isoproterenol; Male; Pentobarbital; Propranolol; Receptors, Adrenergic, beta; Verapamil | 1986 |
Calcium channel antagonist induced inhibition of superoxide production in human neutrophils. Mechanisms independent of antagonizing calcium influx.
Topics: Calcium; Calcium Channel Blockers; Diltiazem; Egtazic Acid; Humans; Kinetics; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Nifedipine; Nisoldipine; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate; Verapamil | 1986 |
Selective drug action on two Ca2+ uptake processes in normal and hyperexcitable presynaptic membrane.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Rana catesbeiana; Synaptic Membranes; Synaptic Transmission; Verapamil | 1986 |
Effects of nifedipine, verapamil, and diltiazem on [3H]-nitrendipine binding to the purified canine cardiac sarcolemmal membrane.
Topics: Animals; Calcium Channels; Diltiazem; Dogs; In Vitro Techniques; Myocardium; Nifedipine; Receptors, Nicotinic; Sarcolemma; Verapamil | 1985 |
Differential effects of Ca antagonists on the noradrenaline release and contraction evoked by nerve stimulation in the presence of 4-aminopyridine.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Norepinephrine; Salicylates; Salicylic Acid; Stereoisomerism; Tetracaine; Tetrodotoxin; Verapamil | 1987 |
Calmodulin-stimulated plasma membrane (Ca2+ + Mg2+)-ATPase: inhibition by calcium channel entry blockers.
Topics: Ca(2+) Mg(2+)-ATPase; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Cinnarizine; Diltiazem; Erythrocyte Membrane; Humans; Kinetics; Sodium-Potassium-Exchanging ATPase; Verapamil | 1987 |
Stable analogues of prostacyclin and thromboxane A2 display contradictory influences on atherosclerotic properties of cells cultured from human aorta. The effect of calcium antagonists.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Aorta; Arteriosclerosis; Cells, Cultured; Diltiazem; DNA Replication; Epoprostenol; Humans; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Prostaglandins, Synthetic; Verapamil | 1988 |
Early transmembrane events in alloimmune cytotoxic T-lymphocyte activation as revealed by stopped-flow fluorometry.
Topics: Animals; Biological Transport; Calcium; Cell Line; Concanavalin A; Cytotoxicity Tests, Immunologic; Diltiazem; Fluorescent Dyes; Fluorometry; Lymphocyte Activation; Lymphoma; Mast-Cell Sarcoma; Membrane Fluidity; Mice; T-Lymphocytes, Cytotoxic; Verapamil | 1986 |
A pharmacological analysis of the pathophysiological mechanisms of posttraumatic spinal cord ischemia.
Topics: Animals; Benzofurans; Calcium Channel Blockers; Cats; Cyclooxygenase Inhibitors; Diltiazem; Dinoprost; Epoprostenol; Female; Ibuprofen; Ischemia; Male; Meclofenamic Acid; Nifedipine; Prostaglandin Antagonists; Prostaglandins F; Spinal Cord; Thromboxane A2; Verapamil; Vitamin E | 1986 |
Effect of verapamil on prostaglandin E2 synthesis by hydronephrotic rabbit cortical interstitial cells in primary culture.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Calcimycin; Calcium; Cells, Cultured; Diltiazem; Dinoprostone; Dose-Response Relationship, Drug; Hydronephrosis; Kidney Cortex; Magnesium; Male; Nifedipine; Prostaglandins E; Quinacrine; Rabbits; Trifluoperazine; Verapamil | 1986 |
Inhibition of human platelet aggregation and cytoplasmic calcium response by calcium antagonists: studies with aequorin and quin2.
Topics: Adenosine Diphosphate; Aequorin; Aminoquinolines; Arachidonic Acid; Arachidonic Acids; Blood Platelets; Calcimycin; Calcium; Calcium Channel Blockers; Culture Media; Cytoplasm; Diglycerides; Diltiazem; Epinephrine; Fluorescent Dyes; Humans; Luminescent Proteins; Nifedipine; Platelet Aggregation; Thrombin; Verapamil | 1986 |
Effects of nitroglycerin, dipyridamole, nifedipine, verapamil and diltiazem on canine coronary arterial rings contracted with 5-hydroxytryptamine and anoxia.
Topics: Animals; Arteries; Calcium; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dipyridamole; Dogs; Female; Hypoxia; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Serotonin; Verapamil | 1986 |
Calcium-induced damage of skeletal muscle fibers is markedly reduced by calcium channel blockers.
Topics: Animals; Calcium; Calcium Channel Blockers; Creatine Kinase; Diltiazem; Edetic Acid; Extracellular Space; Male; Muscles; Muscular Diseases; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1986 |
The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations.
Topics: Blood Platelets; Calcimycin; Calcium; Cytoplasm; Diltiazem; Humans; Kinetics; Molecular Weight; Nimodipine; Phosphoproteins; Plant Extracts; Platelet Aggregation; Serotonin; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Verapamil | 1987 |
Mode of vasorelaxing action of 5-[3-[[2-(3,4-dimethoxyphenyl)-ethyl]amino]-1-oxopropyl]-2,3,4,5- tetrahydro-1,5-benzothiazepine fumarate (KT-362), a new intracellular calcium antagonist.
Topics: Animals; Caffeine; Calcium Channel Blockers; Diltiazem; Egtazic Acid; Gallopamil; Lanthanum; Male; Methoxamine; Muscle Contraction; Nifedipine; Nitroglycerin; Norepinephrine; Rabbits; Thiazepines; Vasodilation; Verapamil | 1987 |
Interleukin-2 stimulus-response coupling is calcium independent.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Diltiazem; Humans; Interleukin-2; Lymphocyte Activation; Nifedipine; Rats; Receptors, Immunologic; Receptors, Interleukin-2; Verapamil | 1987 |
[Effects of calcium antagonists on intracellular calcium deposits].
Topics: Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Diltiazem; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitroglycerin; Rabbits; Verapamil | 1987 |
Combined effects of calcium antagonists and nitroglycerin on large coronary artery diameter.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dogs; Drug Interactions; Nifedipine; Nitroglycerin; Vasodilation; Verapamil | 1988 |
Effects of calcium-channel antagonists on tardive dyskinesia and psychosis.
Topics: Adult; Animals; Calcium Channel Blockers; Diltiazem; Dyskinesia, Drug-Induced; Humans; Infant, Newborn; Middle Aged; Psychotic Disorders; Verapamil | 1988 |
Interaction between Ca2+ antagonists and digitalis.
Topics: Calcium Channel Blockers; Digitalis; Dihydropyridines; Diltiazem; Drug Interactions; Humans; Plants, Medicinal; Plants, Toxic; Verapamil | 1988 |
Abolition of spontaneous rhythmic contractions of isolated monkey coronary arteries by diltiazem, nifedipine, verapamil and nicorandil but not by nitroglycerin.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Erythrocebus patas; Female; In Vitro Techniques; Macaca mulatta; Male; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Verapamil | 1985 |
Specific binding of the calcium antagonist [3H]verapamil to membrane fractions from plants.
Topics: Binding Sites; Diltiazem; Hydrogen-Ion Concentration; Kinetics; Membranes; Nifedipine; Nitrendipine; Plants; Verapamil | 1985 |
The classification of calcium antagonists by the WHO expert committee: relevance in neurology.
Topics: Brain Diseases; Calcium Channel Blockers; Diltiazem; Flunarizine; Humans; Nifedipine; Verapamil | 1988 |
[Clinically important interactions of carbamazepine with verapamil and diltiazem].
Topics: Carbamazepine; Diltiazem; Drug Interactions; Humans; Verapamil | 1988 |
Protection of cardiac membrane phospholipid against oxidative injury by calcium antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Heart; In Vitro Techniques; Lipid Peroxides; Male; Membrane Lipids; Myocardium; Nifedipine; Phospholipids; Rats; Verapamil; Xanthine Oxidase | 1988 |
Intracellular mechanisms of verapamil and diltiazem action on striated muscle of the rabbit.
Topics: Animals; Calcium; Diltiazem; Muscle Contraction; Muscle Proteins; Papillary Muscles; Rabbits; Sarcoplasmic Reticulum; Verapamil | 1988 |
[Calcium inhibitors and treatment of arterial hypertension].
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Hypertension; Verapamil | 1988 |
Correction of systolic time intervals for heart rate: a comparison of individual with population derived regression equations.
Topics: Adult; Atropine; Calcium Channel Blockers; Diltiazem; Electrocardiography; Female; Heart Rate; Humans; Male; Nifedipine; Phonocardiography; Propranolol; Regression Analysis; Verapamil | 1988 |
Comparison of the cardiovascular effects of trans-diclofurime with different types of calcium antagonists in conscious spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Heart Rate; Hemodynamics; Hypertension; Male; Nifedipine; Oximes; Rats; Rats, Inbred SHR; Time Factors; Verapamil | 1988 |
Diltiazem and verapamil reduce the loss of adenine nucleotide metabolites from hypoxic hearts.
Topics: Adenine Nucleotides; Adenosine; Animals; Body Water; Calcium; Creatine Kinase; Diltiazem; Female; Heart; Hypoxanthine; Hypoxanthines; Hypoxia; In Vitro Techniques; Inosine; Kinetics; Male; Myocardial Contraction; Myocardium; Perfusion; Rabbits; Reference Values; Verapamil | 1988 |
Effects of prenatal and postnatal exposure to Ca2+-antagonist agents on rat vasomotor reactivity development.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Carotid Sinus; Diltiazem; Female; Nimodipine; Norepinephrine; Pregnancy; Pressoreceptors; Rats; Verapamil | 1988 |
Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonists in conscious, spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Intravenous; Male; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Verapamil | 1988 |
Effects of benidipine hydrochloride on atrioventricular conduction time and postural reflex in gallamine-immobilized cats.
Topics: Animals; Antihypertensive Agents; Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; Cats; Diltiazem; Dose-Response Relationship, Drug; Gallamine Triethiodide; Heart Conduction System; Heart Rate; Hypotension, Orthostatic; Immobilization; Nifedipine; Phenoxybenzamine; Posture; Verapamil | 1988 |
A comparison of the effects of the calcium entry blockers, verapamil, diltiazem and flunarizine against contractions of the rat isolated aorta and portal vein.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Flunarizine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Rats; Rats, Inbred Strains; Verapamil | 1988 |
Renal effects of calcium channel blockers in vivo.
Topics: Animals; Diltiazem; Diuresis; Electrolytes; Glomerular Filtration Rate; Nifedipine; Rabbits; Verapamil | 1988 |
[Controlled hypotension: a future indication for calcium inhibitors?].
Topics: Anesthesia, General; Blood Pressure; Calcium Channel Blockers; Diltiazem; Humans; Hypotension, Controlled; Nicardipine; Nifedipine; Postoperative Period; Verapamil | 1988 |
The effect of verapamil, diltiazem and nifedipine on baroreceptor reflexes.
Topics: Animals; Atropine; Blood Pressure; Diltiazem; Heart Rate; Male; Nifedipine; Phenylephrine; Pressoreceptors; Propranolol; Rats; Rats, Inbred Strains; Reflex; Verapamil | 1988 |
Effect of calcium channel blocker diltiazem on cytoprotection and prostaglandin and sulfhydryl production by rat gastric epithelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cells, Cultured; Diltiazem; Dinoprostone; Epithelium; Ethanol; Gastric Mucosa; Indomethacin; Prostaglandins; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Taurocholic Acid; Verapamil | 1988 |
Effects of Ca++-antagonists on systemic capacitance vessels and venous return curves of dogs--a study with mean circulatory pressure.
Topics: Animals; Blood Pressure; Blood Vessels; Blood Volume; Calcium Channel Blockers; Cardiac Output; Diltiazem; Dogs; Hematocrit; Infusions, Intravenous; Nicardipine; Nifedipine; Norepinephrine; Reproducibility of Results; Vascular Resistance; Verapamil | 1988 |
Hemodynamic and electrocardiographic actions of the new intracellular calcium antagonist, KT-362, in the conscious dog.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Hemodynamics; Male; Thiazepines; Verapamil | 1988 |
Effect of calcium-entry blockers on the diuretic response to hydrochlorothiazide in the rat.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Diuresis; Female; Hydrochlorothiazide; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Sodium; Verapamil | 1988 |
[Calcium antagonists in angina pectoris].
Topics: Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Diltiazem; Gallopamil; Humans; Nifedipine; Physical Exertion; Verapamil | 1988 |
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline; Verapamil | 1988 |
[Interactions of propranolol with nifedipine, verapamil and diltiazem].
Topics: Adult; Angina Pectoris; Diltiazem; Drug Interactions; Drug Therapy, Combination; Humans; Male; Middle Aged; Nifedipine; Propranolol; Verapamil | 1988 |
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta.
Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil | 1988 |
[Calcium channel blockers and their value in the treatment of bronchial asthma].
Topics: Asthma; Bronchi; Bronchodilator Agents; Diltiazem; Drug Evaluation; Humans; Nifedipine; Verapamil | 1988 |
[Pharmacology of calcium antagonists].
Topics: Bepridil; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Nifedipine; Pyrrolidines; Verapamil | 1988 |
Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat.
Topics: Animals; Bencyclane; Bepridil; Brain; Calcium Channel Blockers; Cinnarizine; Diltiazem; Electroencephalography; Fendiline; Flunarizine; Gallopamil; Heart Rate; Hypoxia; Nimodipine; Prenylamine; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration; Verapamil | 1988 |
The effects of calcium-blocking agents on sympathetic responses to acute haemorrhagic shock in dogs.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Female; Hemodynamics; Male; Nifedipine; Renin; Shock, Hemorrhagic; Sympathetic Nervous System; Verapamil | 1987 |
Cardiovascular interactions of lidocaine with verapamil or diltiazem in the dog.
Topics: Animals; Diltiazem; Dogs; Drug Interactions; Female; Hemodynamics; Lidocaine; Male; Verapamil | 1988 |
Gynecomastia associated with calcium channel blocker therapy.
Topics: Aged; Calcium Channel Blockers; Diltiazem; Drug Administration Schedule; Gynecomastia; Humans; Male; Middle Aged; Nifedipine; Product Surveillance, Postmarketing; Recurrence; Time Factors; Verapamil | 1988 |
Interaction of theophylline, verapamil, and diltiazem on hamster diaphragm muscle force in vitro.
Topics: Animals; Calcium; Cricetinae; Diaphragm; Diltiazem; Drug Interactions; In Vitro Techniques; Mesocricetus; Muscles; Theophylline; Verapamil | 1988 |
Reversibility of acute alcohol cardiac depression: 31P NMR in hamsters.
Topics: Adenine Nucleotides; Animals; Calcium; Chromatography, High Pressure Liquid; Coronary Circulation; Cricetinae; Diltiazem; Ethanol; Heart; Magnetic Resonance Spectroscopy; Mesocricetus; Oxygen Consumption; Phosphorus; Verapamil | 1988 |
Accumulation of aluminum by rabbit renal cortex.
Topics: 2,4-Dinitrophenol; Aluminum; Animals; Diltiazem; Dinitrophenols; Female; In Vitro Techniques; Kidney Cortex; Lanthanum; Rabbits; Sodium Cyanide; Uncoupling Agents; Verapamil | 1988 |
Conscious state comparisons of the effects of the inhalation anesthetics and diltiazem, nifedipine, or verapamil on specialized atrioventricular conduction times in spontaneously beating dog hearts.
Topics: Anesthesia, Inhalation; Animals; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Dogs; Drug Interactions; Enflurane; Female; Halothane; Heart Conduction System; Isoflurane; Male; Nifedipine; Verapamil; Wakefulness | 1988 |
Calcium entry blockers and human platelet aggregation.
Topics: Adult; Calcium Channel Blockers; Diltiazem; Female; Humans; In Vitro Techniques; Male; Platelet Aggregation Inhibitors; Verapamil | 1988 |
Effect of different Ca2+ entry blockers on dopamine-induced inhibition of in vitro prolactin secretion.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dopamine Antagonists; Flunarizine; In Vitro Techniques; Nimodipine; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Verapamil | 1988 |
Differential effects of calcium channel blocking agents on pancuronium- and suxamethonium-induced neuromuscular blockade.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Drug Synergism; Female; In Vitro Techniques; Muscle Contraction; Neuromuscular Junction; Nicardipine; Pancuronium; Rats; Rats, Inbred Strains; Succinylcholine; Verapamil | 1988 |
Quin2 microfluorometry and effects of verapamil and diltiazem on calcium release from rat aorta smooth muscle cells in primary culture.
Topics: Aminoquinolines; Animals; Aorta; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytosol; Diltiazem; Male; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Norepinephrine; Rats; Verapamil | 1988 |
Effect of 1,25-dihydroxyvitamin D3 on cytosolic calcium in dispersed parathyroid cells.
Topics: Animals; Calcitriol; Calcium; Cattle; Cytosol; Diltiazem; In Vitro Techniques; Indoles; Parathyroid Glands; Verapamil | 1988 |
Effects of verapamil, diltiazem and nifedipine on some parameters of hemostasis in the rat.
Topics: Animals; Bleeding Time; Depression, Chemical; Diltiazem; Hemostasis; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1988 |
The effects of calcium channel blocking drugs on halothane initiation of malignant hyperthermia in MHS swine and on the established syndrome.
Topics: Anesthesia, General; Animals; Calcium Channel Blockers; Diltiazem; Flunarizine; Halothane; Malignant Hyperthermia; Nifedipine; Nisoldipine; Swine; Verapamil | 1988 |
Neuromuscular block by verapamil and diltiazem and inhibition of acetylcholine release.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Diaphragm; Diltiazem; Electric Stimulation; In Vitro Techniques; Membrane Potentials; Mice; Mice, Inbred ICR; Muscle Contraction; Neuromuscular Junction; Phrenic Nerve; Tubocurarine; Verapamil | 1988 |
Effect of different calcium modulators on motilin-induced contractions of the rabbit duodenum. Comparison with acetylcholine.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Duodenum; Gallic Acid; In Vitro Techniques; Motilin; Muscle Contraction; Muscle, Smooth; Rabbits; Trifluoperazine; Verapamil | 1988 |
Effect of intravenous and oral calcium antagonists (diltiazem and verapamil) on sustenance of atrial fibrillation.
Topics: Administration, Oral; Adult; Atrial Fibrillation; Blood Pressure; Calcium Channel Blockers; Diltiazem; Female; Humans; Injections, Intravenous; Male; Middle Aged; Time Factors; Verapamil | 1988 |
A novel 1,4-dihydropyridine-binding site on mitochondrial membranes from guinea-pig heart, liver and kidney.
Topics: Animals; Binding Sites; Centrifugation, Density Gradient; Dihydropyridines; Diltiazem; Guinea Pigs; Intracellular Membranes; Kidney; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Nitrendipine; Osmolar Concentration; Subcellular Fractions; Verapamil | 1988 |
The effect of calcium antagonists on allergic pulmonary distress in actively sensitized rats.
Topics: Administration, Oral; Aerosols; Animals; Asthma; Calcium Channel Blockers; Diltiazem; Female; Nifedipine; Ovalbumin; Rats; Rats, Inbred Strains; Verapamil | 1987 |
Effects of diltiazem and verapamil on responses to acetylcholine.
Topics: Acetylcholine; Action Potentials; Animals; Diltiazem; In Vitro Techniques; Male; Mice; Motor Endplate; Tumor Cells, Cultured; Verapamil | 1987 |
Comparison of the effects of calcium channel blockers and antiarrhythmic drugs on digitalis-induced oscillatory afterpotentials on canine Purkinje fiber.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Digitalis; Diltiazem; Dogs; Electric Stimulation; Female; Heart Conduction System; Male; Mexiletine; Nicardipine; Nifedipine; Nitrendipine; Plants, Medicinal; Plants, Toxic; Procainamide; Propranolol; Purkinje Fibers; Verapamil | 1987 |
Effect of calcium channel blockers and trifluoperazine on rat liver regeneration.
Topics: Animals; Calcium; Diltiazem; DNA; Hepatectomy; Injections, Intraperitoneal; Liver; Male; Nifedipine; Rats; Rats, Inbred Strains; Thymidine Kinase; Thymidylate Synthase; Trifluoperazine; Verapamil | 1987 |
Non-invasive electrophysiological evaluation of calcium antagonist long-term therapy.
Topics: Aged; Calcium Channel Blockers; Diltiazem; Electrocardiography; Female; Heart Block; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1987 |
Compared effects of calcium entry blockers on calcium-induced tension in rat isolated cerebral and peripheral resistance vessels.
Topics: Animals; Calcium; Calcium Channel Blockers; Cerebral Arteries; Diltiazem; Female; In Vitro Techniques; Nicardipine; Nifedipine; Rats; Rats, Inbred Strains; Serotonin; Vascular Resistance; Verapamil | 1987 |
[Calcium antagonists in ischemic heart disease].
Topics: Calcium Channel Blockers; Coronary Disease; Diltiazem; Hemodynamics; Humans; Nifedipine; Verapamil | 1987 |
Use of combined calcium channel blockers for therapy of refractory angina pectoris.
Topics: Adult; Angina Pectoris; Benzazepines; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1986 |
Calcium channel antagonists--cardiovascular therapy for the eighties?
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Humans; Hypertension; Nifedipine; Verapamil | 1986 |
Calcium antagonists in the treatment of Tourette's disorder.
Topics: Adult; Calcium Channel Blockers; Child; Diltiazem; Female; Humans; Male; Tourette Syndrome; Verapamil | 1986 |
The use of calcium antagonists in patients with renal failure.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Kidney Failure, Chronic; Nifedipine; Nitrendipine; Verapamil | 1987 |
Effects of calcium channel blockers on sinoatrial conduction in the isolated and blood-perfused dog atrium.
Topics: Animals; Bepridil; Calcium Channel Blockers; Dilazep; Diltiazem; Dogs; Heart Rate; In Vitro Techniques; Isoindoles; Myocardial Contraction; Phthalimides; Pyrrolidines; Sinoatrial Node; Verapamil | 1986 |
Protection of ischemic hearts by Ca2+ antagonists.
Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Coronary Disease; Diltiazem; Energy Metabolism; Lactates; Lactic Acid; Mitochondria, Heart; Myocardial Contraction; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Comparative electrophysiologic effects of bepridil, verapamil and diltiazem in conscious and anesthetized dogs.
Topics: Anesthesia, General; Animals; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart Conduction System; Hemodynamics; Male; Pentobarbital; Pyrrolidines; Sinoatrial Node; Verapamil | 1986 |
Comparative effects of bepridil, diltiazem, nifedipine and verapamil on haemodynamic parameters and myocardial oxygen consumption in anaesthetized dogs.
Topics: Animals; Bepridil; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Female; Heart; Hemodynamics; Male; Myocardium; Nifedipine; Oxygen Consumption; Pyrrolidines; Vascular Resistance; Verapamil | 1986 |
The influx of Ca2+ induced by the administration of glucagon and Ca2+-mobilizing agents to the perfused rat liver could involve at least two separate pathways.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Diltiazem; Epidermal Growth Factor; Glucagon; Liver; Male; Neomycin; Nifedipine; Perfusion; Rats; Rats, Inbred Strains; Verapamil | 1987 |
Effects of calcium-antagonists and calmodulin inhibitors on DNA synthesis in cultured rat vascular smooth muscle cells.
Topics: Animals; Calcium Channel Blockers; Calmodulin; Cells, Cultured; Diltiazem; DNA Replication; Dose-Response Relationship, Drug; Epidermal Growth Factor; Male; Muscle, Smooth, Vascular; Nicardipine; Platelet-Derived Growth Factor; Rats; Rats, Inbred Strains; Sulfonamides; Trifluoperazine; Verapamil | 1987 |
Effects of calcium entry blockers on blood pressure and heart rate in neurogenic hypertensive dogs.
Topics: Animals; Bepridil; Blood Pressure; Calcium Channel Blockers; Denervation; Diltiazem; Dogs; Female; Heart Rate; Hypertension; Male; Nicardipine; Nifedipine; Pyrrolidines; Sinoatrial Node; Verapamil | 1987 |
Effects of calcium channel blockers and insulin on the platelet function in patients with diabetes mellitus.
Topics: Calcium Channel Blockers; Diabetes Mellitus; Diltiazem; Humans; Insulin; Platelet Aggregation; Verapamil | 1986 |
Calcium antagonists stimulate prostaglandin synthesis by cultured rat cardiac myocytes and prevent the effects of hypoxia.
Topics: Animals; Bepridil; Calcium Channel Blockers; Cells, Cultured; Cobalt; Diltiazem; Dinoprostone; Epoprostenol; Fibroblasts; Glycogen; Heart; Hypoxia; Myocardium; Prostaglandins E; Pyrrolidines; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Diltiazem or verapamil prevents haloperidol-induced apomorphine supersensitivity in mice.
Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Diltiazem; Drug Hypersensitivity; Haloperidol; Mice; Mice, Inbred Strains; Nifedipine; Verapamil | 1987 |
Membrane activity, antioxidant, antiaggregatory and antihemolytic properties of four calcium channel blockers.
Topics: Animals; Antioxidants; Blood Platelets; Calcium Channel Blockers; Cell Membrane; Diltiazem; Erythrocytes; Fendiline; Hemolysis; In Vitro Techniques; Nifedipine; Platelet Aggregation; Rabbits; Verapamil | 1986 |
[Comparative hemodynamic effects of nifedipine, verapamil and diltiazem in cases of acute myocardial infarction].
Topics: Diltiazem; Hemodynamics; Humans; Middle Aged; Myocardial Infarction; Nifedipine; Verapamil | 1986 |
[Clinical pharmacology of calcium antagonists].
Topics: Aging; Arrhythmias, Cardiac; Biological Availability; Calcium Channel Blockers; Diltiazem; Drug Interactions; Half-Life; Heart Failure; Humans; Kidney; Liver; Liver Diseases; Nifedipine; Verapamil | 1987 |
The mechanism of centrally mediated cardiovascular actions of the three structurally different calcium antagonists, verapamil, diltiazem and nicardipine, in rats.
Topics: Animals; Blood Pressure; Brain; Cardiovascular System; Diltiazem; Heart Rate; Injections, Intravenous; Injections, Intraventricular; Male; Nicardipine; Rats; Rats, Inbred Strains; Verapamil | 1987 |
Hyperplastic gingivitis during diltiazem therapy.
Topics: Calcium Channel Blockers; Diltiazem; Gingiva; Gingivitis; Humans; Hyperplasia; Male; Middle Aged; Verapamil | 1987 |
Comparative effects of verapamil, diltiazem and felodipine during experimental digitalis-induced arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Dogs; Felodipine; Female; Male; Nitrendipine; Ouabain; Verapamil | 1987 |
Inhibition of platelet-activating factor binding to human platelets by calcium channel blockers.
Topics: Adult; Blood Platelets; Calcium Channel Blockers; Diltiazem; Humans; Platelet Activating Factor; Platelet Aggregation; Protein Binding; Verapamil | 1987 |
Interaction of AOA 39, D600, verapamil and diltiazem with cardiac cholinergic effects.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Gallopamil; Heart Conduction System; Isoindoles; Nifedipine; Phthalimides; Purkinje Fibers; Quinuclidinyl Benzilate; Rabbits; Radioligand Assay; Receptors, Muscarinic; Tritium; Verapamil | 1987 |
Can calcium antagonists affect the hemostatic mechanism and promote rebleeding? An experimental study.
Topics: Animals; Diltiazem; Male; Rats; Rats, Inbred Strains; Recurrence; Subarachnoid Hemorrhage; Verapamil | 1987 |
Different inhibitions of the voltage-dependent K+ current by Ca2+ antagonists in the smooth muscle cell membrane of rabbit small intestine.
Topics: Animals; Calcium Channel Blockers; Cell Membrane; Diltiazem; Electric Conductivity; Intestine, Small; Muscle, Smooth; Potassium; Rabbits; Tetraethylammonium Compounds; Verapamil | 1987 |
Tissue distribution of digoxin in the presence of calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Digoxin; Diltiazem; Guinea Pigs; Male; Tissue Distribution; Verapamil | 1987 |
Frequency-dependent myocardial depression induced by verapamil in conscious dogs.
Topics: Animals; Blood Pressure; Diltiazem; Dogs; Heart Rate; Myocardial Contraction; Nifedipine; Verapamil; Wakefulness | 1987 |
The antithrombogenic in vivo effects of calcium channel blockers in experimental thrombosis in mice.
Topics: Animals; Calcium Channel Blockers; Collagen; Dihydropyridines; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Epinephrine; Male; Mice; Mice, Inbred Strains; Nifedipine; Thrombosis; Time Factors; Verapamil | 1987 |
A comparison of the cardiac and vasodilatory effects of some calcium entry blockers in perfused isolated guinea-pig hearts.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Nifedipine; Perfusion; Vasodilator Agents; Verapamil | 1987 |
Comparative effects of verapamil, tiapamil, diltiazem and nifedipine on systemic and splanchnic hemodynamics in man.
Topics: Adult; Calcium Channel Blockers; Diltiazem; Hemodynamics; Humans; Male; Nifedipine; Propylamines; Splanchnic Circulation; Tiapamil Hydrochloride; Verapamil | 1987 |
Physiological, pharmacological and pathological factors affecting the pharmacokinetics of calcium entry blockers.
Topics: Aging; Animals; Calcium Channel Blockers; Diltiazem; Drug Administration Schedule; Guinea Pigs; Humans; Isomerism; Liver; Liver Diseases; Monitoring, Physiologic; Nifedipine; Phenotype; Verapamil | 1987 |
Verapamil as an apparent competitive antagonist of the serotonin receptor of rabbit isolated aorta.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Cinnarizine; Diltiazem; Flunarizine; Gallopamil; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rabbits; Receptors, Serotonin; Verapamil | 1986 |
[Electrophysiologic and hemodynamic effects of diltiazem].
Topics: Adolescent; Adult; Aged; Benzazepines; Diltiazem; Electrophysiology; Female; Hemodynamics; Humans; Male; Middle Aged; Sick Sinus Syndrome; Verapamil | 1986 |
Effects of verapamil and diltiazem: correction.
Topics: Animals; Benzazepines; Cats; Cerebrovascular Disorders; Diltiazem; Verapamil | 1986 |
Blocking effects of verapamil on pancreatic exocrine secretion induced by dopamine in the dog.
Topics: Animals; Bicarbonates; Dilazep; Diltiazem; Dogs; Dopamine; Female; Male; Pancreas; Pancreatic Juice; Secretin; Verapamil | 1986 |
Calcium channel blockers stimulate LDL receptor synthesis in human skin fibroblasts.
Topics: Calcium Channel Blockers; Diltiazem; Fibroblasts; Half-Life; Humans; Hydroxycholesterols; Lipoproteins, LDL; Methionine; Receptors, LDL; Skin; Verapamil | 1986 |
Intravenous diltiazem for the treatment of supraventricular tachycardia.
Topics: Adult; Atrioventricular Node; Benzazepines; Blood Pressure; Digoxin; Diltiazem; Female; Heart Rate; Humans; Infusions, Parenteral; Male; Middle Aged; Tachycardia, Paroxysmal; Verapamil | 1986 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Calcium entry blocking activity of adenosine potentiating compounds in guinea pig taenia coli.
Topics: Adenosine; Animals; Calcium Channel Blockers; Colon; Dilazep; Diltiazem; Dipyridamole; Drug Synergism; Guinea Pigs; In Vitro Techniques; Lidoflazine; Male; Muscle, Smooth; Nifedipine; Potassium; Vasodilator Agents; Verapamil | 1986 |
Comparison of the effects of nifedipine, diltiazem and verapamil on the mechanical activity of rabbit papillary muscles induced by barium chloride.
Topics: Animals; Barium; Barium Compounds; Benzazepines; Chlorides; Diltiazem; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Myocardial Contraction; Nifedipine; Papillary Muscles; Rabbits; Sodium; Verapamil | 1986 |
[Different sites of action of diltiazem, nifedipine and verapamil on the myocardium and aortic and coronary smooth muscles].
Topics: Animals; Aorta; Benzazepines; Calcium; Coronary Vessels; Diltiazem; Female; Heart; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Rabbits; Verapamil | 1986 |
Effect of Ca2+ antagonists on mechanical function in the neonatal heart.
Topics: Animals; Animals, Newborn; Benzazepines; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Heart; In Vitro Techniques; Myocardial Contraction; Perfusion; Rabbits; Verapamil | 1986 |
Direct effects of diltiazem, nifedipine and verapamil on peripheral sympathetic nerve function, cardiac impulse conduction and cardiovascular function in anesthetized dogs subjected to ganglionic blockade.
Topics: Animals; Autonomic Fibers, Postganglionic; Autonomic Nerve Block; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Dogs; Heart Conduction System; Heart Rate; Nifedipine; Sympathetic Nervous System; Verapamil | 1986 |
Effects of calcium channel blockers on neuromuscular blockade induced by aminoglycoside antibiotics.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium Channel Blockers; Diaphragm; Diltiazem; Drug Synergism; Female; Neomycin; Neuromuscular Blocking Agents; Neuromuscular Junction; Nifedipine; Rats; Rats, Inbred Strains; Streptomycin; Verapamil | 1986 |
Effects of calcium-antagonists on norepinephrine release from sympathetic nerve endings in rat mesenteric vasculature.
Topics: Animals; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Mesenteric Arteries; Nerve Endings; Norepinephrine; Rats; Sympathetic Nervous System; Verapamil | 1986 |
Frequency-dependent effects of calcium antagonists on atrioventricular conduction and refractoriness: demonstration and characterization in anesthetized dogs.
Topics: Animals; Atrioventricular Node; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart Conduction System; Heart Rate; Male; Nifedipine; Refractory Period, Electrophysiological; Verapamil | 1986 |
Direct effects of calcium channel blockers on duodenal calcium transport in vivo.
Topics: Animals; Biological Transport; Biological Transport, Active; Calcium; Calcium Channel Blockers; Diltiazem; Duodenum; Intestinal Absorption; Male; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Antiarrhythmic effect of calcium slow channel blockers (verapamil, nifedipine and diltiazem) in ventricular arrhythmias induced by coronary artery occlusion in dogs.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dogs; Female; Heart Ventricles; Male; Nifedipine; Verapamil | 1986 |
[Calcium antagonists in heart failure?].
Topics: Calcium Channel Blockers; Cardiac Output; Diltiazem; Heart Failure; Heart Rate; Hemodynamics; Humans; Myocardial Contraction; Nifedipine; Sympathetic Nervous System; Vascular Resistance; Verapamil | 1986 |
Protective effects of slow channel calcium antagonists on noradrenaline induced myocardial necrosis.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Female; Heart; Hemodynamics; Male; Myocardium; Necrosis; Nifedipine; Norepinephrine; Verapamil | 1986 |
Why Ca2+ antagonists will be most useful before or during early myocardial ischemia and not after infarction has been established. Danish Study Group on Verapamil in Myocardial Infarction.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Verapamil | 1986 |
Verapamil, diltiazem and nifedipine block the depolarization-induced potentiation of norepinephrine contractions in rabbit aorta and porcine coronary arteries.
Topics: Animals; Aorta; Calcium; Coronary Vessels; Diltiazem; Drug Synergism; Mathematics; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits; Swine; Vasoconstriction; Verapamil | 1986 |
Effect of calcium channel blocking drugs on tumor cell oxygen utilization.
Topics: Animals; Calcium Channel Blockers; Cell Line; Diltiazem; Fibrosarcoma; Glucose; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Nifedipine; Oxygen Consumption; Sarcoma, Experimental; Verapamil | 1986 |
The calcium entry blockers: anti-manic drugs?
Topics: Amphetamines; Animals; Bipolar Disorder; Calcium Channel Blockers; Diltiazem; Hyperkinesis; Male; Mice; Mice, Inbred Strains; Motor Activity; Nicardipine; Oxolinic Acid; Reserpine; Verapamil | 1986 |
Spontaneous remission of variant angina documented by Holter monitoring and ergonovine testing in patients treated with calcium antagonists.
Topics: Acute Disease; Adult; Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Diltiazem; Electrocardiography; Ergonovine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Monitoring, Physiologic; Nifedipine; Remission, Spontaneous; Research Design; Time Factors; Verapamil | 1987 |
The cardiovascular and adrenergic actions of verapamil or diltiazem in combination with propranolol during halothane anesthesia in the dog.
Topics: Anesthesia, Inhalation; Animals; Blood Chemical Analysis; Diltiazem; Dogs; Drug Interactions; Epinephrine; Female; Halothane; Heart Rate; Hemodynamics; Infusions, Intravenous; Male; Norepinephrine; Propranolol; Verapamil | 1987 |
[Usefulness and limitations of the ergonovine maleate test in the evaluation of calcium-antagonist therapy in Prinzmetal variant angina].
Topics: Adult; Aged; Angina Pectoris, Variant; Calcium Channel Blockers; Diltiazem; Ergonovine; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1986 |
Enhanced calcium-sensitivity of erythrocytes in hypertension--calcium-induced changes of erythrocyte osmotic fragility in essential hypertension.
Topics: Adult; Calcium; Calmodulin; Diltiazem; Erythrocytes; Female; Humans; Hypertension; Male; Osmotic Fragility; Trifluoperazine; Verapamil | 1986 |
Comparative effects on blood pressure of different calcium-blocking agents.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Diltiazem; Diuretics; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Verapamil | 1986 |
Pharmacology of calcium antagonists.
Topics: Action Potentials; Animals; Atrioventricular Node; Bepridil; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Guinea Pigs; Heart; Heart Rate; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Pyrrolidines; Rats; Vasodilation; Ventricular Fibrillation; Verapamil | 1985 |
Divergent influences of the structurally dissimilar calcium entry blockers, diltiazem and verapamil, on thyrotropin- and gonadotropin-releasing hormone-stimulated anterior pituitary hormone secretion in man.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Diltiazem; Gonadotropin-Releasing Hormone; Humans; Infusions, Parenteral; Injections, Intravenous; Luteinizing Hormone; Male; Pituitary Hormones, Anterior; Thyrotropin; Time Factors; Verapamil | 1985 |
The effects of lead on the renin-angiotensin system.
Topics: Aldosterone; Animals; Blood Pressure; Diltiazem; Drug Interactions; Erythrocytes; Heart Rate; In Vitro Techniques; Kidney Cortex; Lead; Male; Organometallic Compounds; Rabbits; Renin; Renin-Angiotensin System; Verapamil | 1985 |
Calcium antagonists stimulate sperm motility in ejaculated human semen.
Topics: Calcimycin; Calcium; Calcium Channel Blockers; Cinnarizine; Diltiazem; Dose-Response Relationship, Drug; Egtazic Acid; Flunarizine; Humans; Male; Prenylamine; Sperm Motility; Verapamil | 1985 |
Arterial pressure and heart rate responses to calcium channel blockers administered in the brainstem in rats.
Topics: Animals; Blood Pressure; Brain Stem; Calcium Channel Blockers; Diltiazem; Egtazic Acid; Heart Rate; Injections, Intraventricular; Male; Nifedipine; Rats; Rats, Inbred WKY; Verapamil | 1985 |
Effects of magnesium on the action of vasodilatory agents.
Topics: Animals; Aorta, Thoracic; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Isoproterenol; Magnesium; Nitroglycerin; Rabbits; Vasodilation; Vasodilator Agents; Verapamil | 1985 |
Large scale preparation of rabbit aortic smooth muscle cells for use in calcium uptake studies.
Topics: Animals; Aorta, Thoracic; Biological Transport, Active; Calcium; Cell Line; Diltiazem; Dose-Response Relationship, Drug; Muscle, Smooth, Vascular; Nifedipine; Potassium; Rabbits; Verapamil | 1986 |
Isolated rat cardiac myocytes as an experimental model to study calcium overload: the effect of calcium-entry blockers.
Topics: Animals; Calcium; Calcium Channel Blockers; Cinnarizine; Diltiazem; Flunarizine; Heart; Lidoflazine; Male; Myocardial Contraction; Myocardium; Nicardipine; Nifedipine; Rats; Rats, Inbred Strains; Time Factors; Verapamil; Veratrine | 1986 |
Comparison of the protective effects of verapamil, diltiazem, nifedipine, and buffer containing low calcium upon global myocardial ischemic injury.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Benzazepines; Blood Pressure; Buffers; Calcium; Coronary Disease; Diltiazem; Heart Rate; Myocardial Contraction; Nifedipine; Perfusion; Phosphocreatine; Rats; Verapamil | 1986 |
Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets.
Topics: Benzazepines; Blood Platelets; Buffers; Calcium; Calcium Channel Blockers; Diltiazem; Humans; Male; Nifedipine; Platelet Activating Factor; Platelet Aggregation; Statistics as Topic; Stereoisomerism; Tritium; Verapamil | 1986 |
Comparative effects of calcium-channel blocking agents on left ventricular function during acute ischemia in dogs with and without congestive heart failure.
Topics: Animals; Arterial Occlusive Diseases; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Dogs; Heart; Heart Failure; Heart Ventricles; Myocardial Contraction; Nifedipine; Stroke Volume; Verapamil | 1985 |
Effect of depolarizing concentrations of potassium on calcium uptake and metabolism in rat liver.
Topics: Animals; Calcium; Caprylates; Cytoplasm; Diltiazem; Glycogen; Kinetics; Liver; Mitochondria, Liver; NAD; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1985 |
Effects of calcium entry blockers on coronary constriction and myocardial ischemia due to leukotriene D4.
Topics: Animals; Calcium; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Female; Male; Nifedipine; SRS-A; Swine; Verapamil | 1985 |
Calcium-dependence of serotonin-mediated aldosterone secretion and differential effects of calcium antagonists.
Topics: Adrenal Cortex; Aldosterone; Animals; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Nifedipine; Rats; Rats, Inbred Strains; Serotonin; Verapamil | 1985 |
Calcium antagonists and myocardial protection during cardioplegic arrest.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Creatine Kinase; Diltiazem; Heart Arrest, Induced; Hemodynamics; Hypothermia, Induced; Male; Myocardial Contraction; Nifedipine; Perfusion; Rats; Rats, Inbred Strains; Temperature; Verapamil | 1985 |
Myocardial reoxygenation damage. Can it be circumvented?
Topics: Animals; Calcium; Cats; Coronary Circulation; Diltiazem; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Lidoflazine; Magnesium; Manganese; Myocardial Contraction; Oxygen Consumption; Papillary Muscles; Rabbits; Verapamil | 1985 |
Erythrocyte adenosine transport: effects of Ca2+ channel antagonists and ions.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Adult; Biological Transport; Calcium Channel Blockers; Cations; Chlorides; Diltiazem; Erythrocytes; Humans; Magnesium; Uridine; Verapamil | 1985 |
Myocardial reoxygenation damage: can it be circumvented?
Topics: Animals; Calcium; Cats; Diltiazem; Heart; Hypoxia; In Vitro Techniques; Lidoflazine; Myocardial Contraction; Myocardium; Ouabain; Oxygen; Papillary Muscles; Perfusion; Rabbits; Stimulation, Chemical; Verapamil | 1985 |
[Comparative effects of three calcium antagonists (nifedipine, verapamil and diltiazem) on hemodynamics in recent myocardial infarction].
Topics: Aged; Calcium Channel Blockers; Diltiazem; Drug Evaluation; Echocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Nifedipine; Verapamil | 1985 |
Do D 600 and diltiazem interact with serotonin receptors in rabbit vascular tissues?
Topics: Animals; Aorta; Basilar Artery; Benzazepines; Blood Vessels; Calcium; Dibenzylchlorethamine; Diltiazem; Dose-Response Relationship, Drug; Gallopamil; In Vitro Techniques; Male; Rabbits; Receptors, Serotonin; Serotonin; Vasoconstriction; Verapamil | 1985 |
Inhibition of hepatic microsomal drug metabolism by the calcium channel blockers diltiazem and verapamil.
Topics: Aminopyrine N-Demethylase; Animals; Benzazepines; Cytochrome P-450 Enzyme System; Dealkylation; Diltiazem; In Vitro Techniques; Kinetics; Male; Mice; Microsomes, Liver; Pentobarbital; Pharmaceutical Preparations; Sleep; Verapamil | 1985 |
Effect of verapamil, nifedipine and diltiazem on experimental myocardial infarction in rats.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Female; Isoproterenol; Male; Myocardial Infarction; Nifedipine; Rats; Verapamil | 1985 |
The relative sensitization by acidosis of five calcium blockers in cat papillary muscles.
Topics: Acidosis; Animals; Calcium Channel Blockers; Cats; Diltiazem; In Vitro Techniques; Lidoflazine; Myocardial Contraction; Nifedipine; Papillary Muscles; Perhexiline; Verapamil | 1985 |
[Effects of various calcium antagonists on the muscular activity of the guinea pig ileum].
Topics: Animals; Benzazepines; Diltiazem; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Verapamil | 1985 |
The potencies and selectivities of four calcium antagonists as inhibitors of uterine contractions in the rat in vivo.
Topics: Albuterol; Animals; Blood Pressure; Calcium Channel Blockers; Castration; Diltiazem; Female; Gallopamil; Heart Rate; Nifedipine; Pregnancy; Rats; Rats, Inbred Strains; Uterine Contraction; Verapamil | 1985 |
Effect of verapamil and diltiazem on calcium-dependent electrical activity in cardiac Purkinje fibres.
Topics: Action Potentials; Animals; Barium; Barium Compounds; Benzazepines; Calcium; Chlorides; Diltiazem; Electrophysiology; Heart; Heart Conduction System; In Vitro Techniques; Purkinje Fibers; Sheep; Strophanthidin; Verapamil | 1985 |
Mechanism for electrosilent Ca2+ transport to cause calcification of spicules in sea urchin embryos.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Biological Transport; Calcification, Physiologic; Calcium; Diltiazem; Embryo, Nonmammalian; Morphogenesis; Sea Urchins; Verapamil | 1985 |
Adverse effects of atrial fibrillation and syncope induced by calcium-channel blockers in hypertrophic cardiomyopathy.
Topics: Adult; Atrial Fibrillation; Benzazepines; Cardiomyopathy, Hypertrophic; Diltiazem; Echocardiography; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Propranolol; Syncope; Verapamil | 1985 |
The effects of several ion channel blockers and calmodulin antagonists on fertilization-induced acid release and 45Ca2+ uptake in sea urchin eggs.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Benzazepines; Calcium; Calmodulin; Diltiazem; Female; Fertilization; Hydrogen; Ovum; Sea Urchins; Verapamil | 1985 |
Calcium channel blockers in primary pulmonary hypertension.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Hypertension, Pulmonary; Nifedipine; Verapamil | 1985 |
The porphyrogenic effects of calcium channel blocking drugs.
Topics: 5-Aminolevulinate Synthetase; Animals; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Diltiazem; Liver; Nifedipine; Porphyrins; Verapamil | 1985 |
Effects of verapamil and diltiazem on acute stroke in cats.
Topics: Animals; Benzazepines; Blood Volume; Brain; Brain Edema; Cats; Cerebrovascular Circulation; Cerebrovascular Disorders; Diltiazem; Evoked Potentials, Somatosensory; Verapamil | 1985 |
Effects of oximes, diacetylmonoxime, pyridine-2-aldoxime, and pyridine-2-aldoxime methochloride, on the electrical and mechanical activities of guinea pig cardiac ventricular muscles.
Topics: Action Potentials; Animals; Butanones; Diacetyl; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Pralidoxime Compounds; Time Factors; Verapamil | 1985 |
[Effects of calcium antagonists on conduction delay in myocardial ischemia and reperfusion].
Topics: Animals; Calcium Channel Blockers; Coronary Disease; Coronary Vessels; Diltiazem; Dogs; Heart Conduction System; Ligation; Male; Nifedipine; Perfusion; Verapamil | 1985 |
[Arrhythmias in the elderly patients: atrial fibrillation].
Topics: Aged; Aging; Atrial Fibrillation; Coronary Disease; Diltiazem; Humans; Hypertension; Mitral Valve Insufficiency; Verapamil | 1985 |
Temperature dependence of calcium antagonist action.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Fendiline; Kinetics; Myocardial Contraction; Myocardium; Nifedipine; Rats; Temperature; Verapamil | 1985 |
Relative activities of three calcium channel antagonists on histamine, acetylcholine and antigen-induced contractions of guinea pig ileum.
Topics: Acetylcholine; Animals; Antigens; Atropine; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Ovalbumin; Tripelennamine; Verapamil | 1985 |
Molecular pharmacology of the calcium channel: evidence for subtypes, multiple drug-receptor sites, channel subunits, and the development of a radioiodinated 1,4-dihydropyridine calcium channel label, [125I]iodipine.
Topics: Animals; Anura; Autoradiography; Calcium Channel Blockers; Calcium Channels; Cattle; Diltiazem; Guinea Pigs; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Iodine Radioisotopes; Iodobenzenes; Ion Channels; Ligands; Membranes; Metalloproteins; Microsomes; Rats; Receptors, Nicotinic; Species Specificity; Verapamil | 1984 |
Effects of temperature and allosteric modulators on [3H] nitrendipine binding: methods for detecting potential Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Animals; Benzothiazoles; Binding Sites; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Microsomes; Myocardium; Nifedipine; Nitrendipine; Propylamines; Temperature; Thiazoles; Tiapamil Hydrochloride; Verapamil | 1984 |
Effects of Ca2+ and calmodulin antagonists on the oxygen uptake induced by acetylcholine or substance P in rat submandibular gland slices.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Calmodulin; Chlorpromazine; Diltiazem; In Vitro Techniques; Lanthanum; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Submandibular Gland; Substance P; Sulfonamides; Trifluoperazine; Vasodilator Agents; Verapamil | 1984 |
[Treatment of heart arrhythmias with calcium antagonists].
Topics: Arrhythmias, Cardiac; Atrioventricular Node; Calcium Channel Blockers; Cardiac Complexes, Premature; Coronary Circulation; Diltiazem; Drug Therapy, Combination; Electrocardiography; Gallopamil; Heart Conduction System; Heart Rate; Humans; Risk; Sinoatrial Node; Tachycardia; Verapamil | 1984 |
Verapamil enhances the toxicity of conjugates of epidermal growth factor with Pseudomonas exotoxin and antitransferrin receptor with Pseudomonas exotoxin.
Topics: ADP Ribose Transferases; Antibodies, Monoclonal; Bacterial Toxins; Cell Line; Cell Survival; Diltiazem; Drug Synergism; Epidermal Growth Factor; Exotoxins; Fluorescent Antibody Technique; Humans; Lysosomes; Nifedipine; Pseudomonas aeruginosa Exotoxin A; Receptors, Cell Surface; Receptors, Transferrin; Skin Neoplasms; Verapamil; Virulence Factors | 1984 |
Voltage-gated potassium channels are required for human T lymphocyte activation.
Topics: 4-Aminopyridine; Aminopyridines; Cell Line; Diltiazem; Electrophoresis, Polyacrylamide Gel; Humans; Interleukin-2; Ion Channels; Kinetics; Leucine; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Phytohemagglutinins; Potassium; Protein Biosynthesis; T-Lymphocytes; Thymidine; Verapamil | 1984 |
Stimulation of hepatic glycogenolysis by 12-O-tetradecanoylphorbol-13-acetate (TPA) via a calcium requiring process.
Topics: Animals; Calcimycin; Calcium Chloride; Cyclic AMP; Cyclic GMP; Diltiazem; Glucose; Kinetics; Liver; Liver Glycogen; Male; Phorbols; Proteins; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Trifluoperazine; Verapamil | 1984 |
Properties of receptors for the Ca2+-channel blocker verapamil in transverse-tubule membranes of skeletal muscle. Stereospecificity, effect of Ca2+ and other inorganic cations, evidence for two categories of sites and effect of nucleoside triphosphates.
Topics: Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channels; Cations, Divalent; Cations, Monovalent; Diltiazem; Electrochemistry; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Muscles; Nifedipine; Nitrendipine; Nucleotides; Pyrrolidines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1984 |
(-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle.
Topics: Animals; Binding Sites; Calcium; Diltiazem; Guinea Pigs; Ion Channels; Kinetics; Muscles; Nicotinic Acids; Nimodipine; Stereoisomerism; Subcellular Fractions; Verapamil | 1984 |
The interference of T cell activation by calcium channel blocking agents.
Topics: Adult; Animals; Antibodies, Monoclonal; Antigens, Surface; Calcium; Calcium Channel Blockers; Cytotoxicity, Immunologic; Diltiazem; Humans; Immunosuppressive Agents; Interleukin-2; Lymphocyte Activation; Mice; Nifedipine; T-Lymphocytes; Tumor Necrosis Factor Receptor Superfamily, Member 7; Verapamil | 1984 |
(-)-3H-desmethoxyverapamil labelling of putative calcium channels in brain: autoradiographic distribution and allosteric coupling to 1,4-dihydropyridine and diltiazem binding sites.
Topics: Animals; Autoradiography; Benzazepines; Binding Sites; Brain; Dihydropyridines; Diltiazem; Guinea Pigs; Hippocampus; In Vitro Techniques; Ion Channels; Kinetics; Membranes; Pyridines; Stereoisomerism; Verapamil | 1984 |
Comparative effects of verapamil, nifedipine, and diltiazem on contractile function in the isolated immature and adult rabbit heart.
Topics: Aging; Animals; Benzazepines; Calcium; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Perfusion; Rabbits; Verapamil | 1984 |
Calcium in neural control of renal circulation.
Topics: Animals; Calcium; Diltiazem; Electric Stimulation; Glomerular Filtration Rate; Ion Channels; Kidney; Male; Norepinephrine; Perfusion; Rats; Rats, Inbred Strains; Renal Circulation; Sympathetic Nervous System; Vascular Resistance; Verapamil | 1984 |
Calcium channel blockade in smooth muscle of the human upper urinary tract. I. Effects on depolarization-induced activation.
Topics: Action Potentials; Adult; Aged; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Humans; Ion Channels; Kidney Calices; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Papaverine; Potassium; Ureter; Verapamil | 1984 |
Characterization of verapamil binding sites in cardiac membrane vesicles.
Topics: Animals; Calcium Channels; Diltiazem; Heart Ventricles; Kinetics; Myocardium; Nifedipine; Nitrendipine; Receptors, Nicotinic; Sarcolemma; Swine; Verapamil | 1984 |
Treatment of variant angina with drugs: a survey of 11 cardiology institutes in Japan.
Topics: Adrenergic beta-Antagonists; Adult; Angina Pectoris; Angina Pectoris, Variant; Anticoagulants; Coronary Vessels; Diltiazem; Female; Humans; Japan; Male; Middle Aged; Nifedipine; Placebos; Verapamil | 1981 |
Welcome--the calcium channel blockers.
Topics: Adrenergic beta-Antagonists; Angina Pectoris, Variant; Arrhythmias, Cardiac; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Coronary Disease; Diltiazem; Humans; Ion Channels; Lung Diseases; Nifedipine; Tachycardia; Verapamil | 1981 |
Calcium blockers for heart disease: two approved, more to come.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Humans; Nifedipine; United States; United States Food and Drug Administration; Verapamil | 1982 |
Calcium-channel blockers and beta blockers: advantages and disadvantages of combination therapy in chronic stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Middle Aged; Nifedipine; Propranolol; Verapamil | 1982 |
Further studies on the mechanism of phosphorylase activation in rabbit liver in response to splanchnic nerve stimulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Diltiazem; Electric Stimulation; Enzyme Activation; Indomethacin; Liver; Male; Norepinephrine; Phosphorylase a; Phosphorylases; Rabbits; Splanchnic Nerves; Verapamil | 1982 |
Effects of antianginal drugs on ventricular function, myocardial blood flow and peripheral circulation.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Blood Circulation; Calcium Channel Blockers; Diltiazem; Heart; Heart Ventricles; Humans; Nifedipine; Nitrates; Verapamil | 1982 |
Actions of calcium antagonists on calcium currents in Helix neurons. Specificity and potency.
Topics: Adrenergic beta-Antagonists; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Gallopamil; Helix, Snails; In Vitro Techniques; Ion Channels; Neurons; Temperature; Verapamil | 1983 |
Differential inhibition of vascular smooth muscle responses to alpha 1- and alpha 2-adrenoceptor agonists by diltiazem and verapamil.
Topics: Adrenergic alpha-Agonists; Animals; Benzazepines; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Naphthols; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Verapamil | 1983 |
Presynaptic alpha 2-adrenoceptor antagonism by verapamil but not by diltiazem in rabbit hypothalamic slices.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Calcium Channel Blockers; Clonidine; Cocaine; Diltiazem; Epinephrine; Hypothalamus; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Verapamil | 1983 |
Dopamine antagonist effect of verapamil on isolated perfused rabbit ear artery.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Nifedipine; Nitrendipine; Perfusion; Rabbits; Sulpiride; Vasoconstriction; Verapamil | 1983 |
Effects of verapamil, diltiazem and ryosidine on the release of dopamine and acetylcholine in rabbit caudate nucleus slices.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Caudate Nucleus; Diltiazem; Dopamine; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Organic Chemicals; Potassium; Rabbits; Verapamil | 1984 |
Differential effects of nifedipine, verapamil, and diltiazem on noradrenaline-induced contractions, adrenergic transmitter release, and alpha-adrenoceptor binding in the female rabbit urethra.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Female; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Nifedipine; Norepinephrine; Rabbits; Receptors, Nicotinic; Sympathetic Nervous System; Urethra; Verapamil | 1984 |
[Enhancement of the antifibrillatory efficacy of quinidine in atrial fibrillation by verapamil (author's transl)].
Topics: Animals; Atrial Fibrillation; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Diltiazem; Dogs; Drug Therapy, Combination; Electrocardiography; Female; Male; Quinidine; Verapamil | 1982 |
Effect of an intracellular calcium antagonist (TMB-8) on carbamylcholine-induced amylase release from dispersed rat pancreatic acini.
Topics: Amylases; Animals; Calcium; Calcium Channel Blockers; Carbachol; Diltiazem; Dose-Response Relationship, Drug; Gallic Acid; Pancreas; Rats; Verapamil | 1984 |
Evaluation of calcium entry blockers in several models of immediate hypersensitivity.
Topics: Animals; Arachidonate Lipoxygenases; Arachidonic Acids; Bronchial Spasm; Calcium Channel Blockers; Cinnarizine; Diltiazem; Flunarizine; Guinea Pigs; Histamine Release; Hydroxyeicosatetraenoic Acids; Hypersensitivity, Immediate; Lipoxygenase; Male; Mast Cells; Nifedipine; Rats; Verapamil | 1984 |
Effects of vasodilators on the systemic capacitance vessels, a study with the measurement of the mean circulatory pressure in dogs.
Topics: Animals; Blood Pressure; Blood Vessels; Blood Volume; Cardiac Output; Diltiazem; Dogs; Heart Rate; Isosorbide Dinitrate; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Prazosin; Sydnones; Trapidil; Vascular Resistance; Vasodilator Agents; Venous Pressure; Verapamil | 1984 |
Effects of verapamil, diltiazem, nisoldipine and felodipine on sarcoplasmic reticulum.
Topics: Animals; Calcium Channel Blockers; Calcium-Transporting ATPases; Centrifugation, Density Gradient; Diltiazem; Dogs; Felodipine; In Vitro Techniques; Microsomes; Muscles; Myocardium; Nifedipine; Nisoldipine; Potassium Chloride; Rabbits; Sarcoplasmic Reticulum; Species Specificity; Verapamil | 1984 |
Therapeutic implications of slow-channel blockade in cardiocirculatory disorders.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium; Cardiovascular Diseases; Coronary Disease; Diltiazem; Heart Block; Humans; Ion Channels; Muscle, Smooth, Vascular; Muscles; Myocardial Contraction; Nifedipine; Sodium; Verapamil | 1980 |
Facilitation of Neuromuscular transmission by calcium antagonists, diltiazem, nifedipine and verapamil, in the dog.
Topics: Acetylcholine; Animals; Benzazepines; Blood Pressure; Calcium; Diltiazem; Dogs; Electric Stimulation; Female; Male; Muscle Contraction; Neuromuscular Junction; Nifedipine; Synaptic Transmission; Verapamil | 1981 |
Calcium channels in the heart.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Diltiazem; Electric Conductivity; Heart; Hypertension; Ion Channels; Nifedipine; Vasodilator Agents; Verapamil | 1981 |
Differential effects of systemic and intracoronary calcium channel blocking agents on global and regional left ventricular function in conscious dogs.
Topics: Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Heart Ventricles; Ion Channels; Nifedipine; Pyridines; Verapamil | 1981 |
[Electrophysiologic effects of calcium channel blocking agents on the sinus node function in anesthetized dogs (author's transl)].
Topics: Animals; Benzazepines; Blood Pressure; Calcium; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Ion Channels; Nifedipine; Propranolol; Pyridines; Sinoatrial Node; Verapamil | 1980 |
Differential cardiovascular effects of calcium channel blocking agents: potential mechanisms.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Dose-Response Relationship, Drug; Guinea Pigs; Heart Arrest, Induced; Heart Conduction System; Heart Rate; Hemodynamics; Humans; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Verapamil | 1982 |
Selectivity of calcium antagonistic action in vascular smooth muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Coronary Vasospasm; Coronary Vessels; Diltiazem; Dose-Response Relationship, Drug; Humans; Ion Channels; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium; Rabbits; Verapamil | 1982 |
Differential effects of calcium channel blocking agents on oxygen consumption rate in vascular smooth muscle.
Topics: Animals; Aorta, Abdominal; Calcium; Calcium Channel Blockers; Diltiazem; Ion Channels; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Oxygen Consumption; Potassium; Rabbits; Sodium; Verapamil | 1982 |
Do calcium-dependent ionic currents mediate ischemic ventricular fibrillation?
Topics: Animals; Calcium; Coronary Circulation; Coronary Disease; Death, Sudden; Diltiazem; Heart Conduction System; Heart Rate; Humans; Ion Channels; Membrane Potentials; Myocardium; Ventricular Fibrillation; Verapamil | 1982 |
Comparative clinical electrophysiologic effects of diltiazem, verapamil and nifedipine: a review.
Topics: Atrioventricular Node; Benzazepines; Coronary Disease; Diltiazem; Electrocardiography; Heart Rate; Humans; Ion Channels; Nifedipine; Pyridines; Sinoatrial Node; Verapamil | 1982 |
Protective action of calcium channel antagonist agents against ventricular fibrillation in the isolated perfused rat heart.
Topics: Adenine Nucleotides; Animals; Calcium; Coronary Circulation; Coronary Disease; Cyclic AMP; Diltiazem; Ion Channels; Male; Myocardium; Nifedipine; Rats; Ventricular Fibrillation; Verapamil | 1982 |
Calcium channel blockers for cardiovascular disorders.
Topics: Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Humans; Hypertension; Ion Channels; Nifedipine; Verapamil | 1982 |
Inhibition by calcium channel blockers of the glycogenolytic effect of glucagon in perfused rat liver.
Topics: Animals; Benzazepines; Calcium; Cyanides; Cyclic AMP; Diltiazem; Egtazic Acid; Glucagon; Glucose; Ion Channels; Liver; Liver Glycogen; Male; Phosphorylases; Rats; Rats, Inbred Strains; Verapamil | 1982 |
Mechanisms by which calcium ions regulate the steroidogenic actions of luteinizing hormone in isolated ovarian cells in vitro.
Topics: Animals; Calcimycin; Calcium; Cells, Cultured; Cyclic AMP; Diltiazem; Female; Granulosa Cells; Luteinizing Hormone; Progesterone; Swine; Verapamil | 1982 |
The interaction of calcium antagonists (slow channel blockers) with myocardial alpha adrenoceptors.
Topics: Animals; Brain; Calcium Channel Blockers; Clonidine; Diltiazem; Gallopamil; In Vitro Techniques; Male; Myocardium; Nifedipine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Verapamil | 1982 |
Evidence of multiple receptor sites within the putative calcium channel.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Kinetics; Membranes; Nicotinic Acids; Nimodipine; Prenylamine; Receptors, Drug; Verapamil | 1982 |
Calcium slow channel blockers: physiology and anesthetic interactions.
Topics: Anesthetics; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Dogs; Drug Interactions; Heart Conduction System; Humans; Ion Channels; Nifedipine; Verapamil | 1982 |
Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Cats; Diltiazem; Gallopamil; Heart; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Nifedipine; Nitrendipine; Verapamil | 1983 |
Diltiazem and verapamil preferentially block inactivated cardiac calcium channels.
Topics: Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Ferrets; Ion Channels; Verapamil | 1983 |
Calcium antagonists and calmodulin: effect of verapamil, nifedipine and diltiazem.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Binding Proteins; Calmodulin; Cattle; Diltiazem; Enzyme Activation; In Vitro Techniques; Nifedipine; Phosphoric Diester Hydrolases; Verapamil | 1983 |
Allosteric modulation by diltiazem and verapamil of [3H]nitrendipine binding to calcium channel sites in rat brain.
Topics: Allosteric Site; Animals; Benzazepines; Brain; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Ion Channels; Kinetics; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Synaptosomes; Verapamil | 1983 |
Slow calcium channel blockers and the calcium paradox: comparative studies in the rat with seven drugs.
Topics: Animals; Butylamines; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Fendiline; Gallopamil; In Vitro Techniques; Ion Channels; Male; Myocardium; Nifedipine; Prenylamine; Rats; Verapamil | 1983 |
Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Chick Embryo; Diltiazem; Heart; In Vitro Techniques; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Tritium; Verapamil | 1983 |
Calcium channels resistant to organic calcium entry blockers in a rabbit vein.
Topics: Animals; Benzazepines; Calcium; Cimetidine; Diltiazem; Dose-Response Relationship, Drug; Face; Histamine; Ion Channels; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Phentolamine; Propranolol; Rabbits; Temperature; Veins; Verapamil | 1983 |
A simple sensitive radioreceptor assay for calcium antagonist drugs.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cattle; Cell Membrane; Cerebral Cortex; Diltiazem; In Vitro Techniques; Muscles; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Prenylamine; Radioligand Assay; Receptors, Nicotinic; Verapamil | 1983 |
Modification of drug action by hyperammonemia.
Topics: Acetates; Ammonia; Amphetamine; Animals; Calcium; Cattle; Diltiazem; Drug Interactions; Guinea Pigs; Ileum; Ion Channels; Male; Mice; Morphine; Motor Activity; Muscle Contraction; Verapamil | 1984 |
New drugs for hypertension.
Topics: Antihypertensive Agents; Bumetanide; Diltiazem; Dipeptides; Enalapril; Guanabenz; Guanidines; Humans; Indapamide; Labetalol; Nifedipine; Pindolol; Verapamil | 1984 |
Tissue response selectivity of calcium antagonists is not due to heterogeneity of [3H]-nitrendipine binding sites.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Diltiazem; Female; Gallopamil; In Vitro Techniques; Isometric Contraction; Kinetics; Membranes; Muscle, Smooth, Vascular; Myocardium; Nicardipine; Nifedipine; Organ Specificity; Rabbits; Receptors, Nicotinic; Verapamil | 1984 |
Structure-function relationship of calcium ion channel antagonists at the pituitary gonadotrope.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Gallopamil; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Pituitary Gland; Rats; Structure-Activity Relationship; Verapamil; Veratridine | 1983 |
Diltiazem and verapamil: functional antagonism of exogenous noradrenaline and angiotensin II in man.
Topics: Adult; Angiotensin II; Benzazepines; Blood Pressure; Catecholamines; Diltiazem; Heart Rate; Humans; Male; Norepinephrine; Renin; Verapamil | 1984 |
Antithrombogenic effects of calcium channel blockers: synergism with prostacyclin and thromboxane synthase inhibitors.
Topics: Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium Channel Blockers; Diltiazem; Drug Synergism; Epoprostenol; Humans; Nicotinic Acids; Nifedipine; Nimodipine; Oxidoreductases; Platelet Aggregation; Thrombin; Thromboxane A2; Thromboxane-A Synthase; Verapamil | 1984 |
Calcium antagonist withdrawal syndrome: objective demonstration with frequency-modulated ambulatory ST-segment monitoring.
Topics: Aged; Angina Pectoris; Calcium; Diltiazem; Electrocardiography; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Substance Withdrawal Syndrome; Verapamil | 1983 |
[Strategy of the treatment of vasospastic angina pectoris].
Topics: Adult; Amiodarone; Angina Pectoris, Variant; Arteriosclerosis; Coronary Artery Bypass; Coronary Vasospasm; Diltiazem; Humans; Middle Aged; Nifedipine; Nitroglycerin; Radiography; Verapamil | 1983 |
Vasodilatory action of HA1004 [N-(2-guanidinoethyl)-5-isoquinolinesulfonamide], a novel calcium antagonist with no effect on cardiac function.
Topics: Animals; Aorta; Calcimycin; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Rabbits; Sulfonamides; Vasodilator Agents; Verapamil | 1984 |
Influence of verapamil and diltiazem on aggregatory responses in cat and rabbit platelet rich plasma.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Benzazepines; Calcium Channel Blockers; Cats; Diltiazem; Female; In Vitro Techniques; Male; Platelet Aggregation; Prostaglandin Endoperoxides, Synthetic; Prostaglandin H2; Prostaglandins H; Rabbits; Verapamil | 1984 |
[Prognostic value of coronary spasm threshold determined by the ergometrine test].
Topics: Coronary Vasospasm; Diltiazem; Ergonovine; Humans; Prognosis; Time Factors; Verapamil | 1984 |
[3H]nitrendipine binding to adrenal capsular membranes.
Topics: Adrenal Medulla; Aldosterone; Animals; Binding Sites; Binding, Competitive; Diltiazem; Kinetics; Membranes; Nifedipine; Nitrendipine; Rats; Verapamil | 1984 |
Calcium entry blockers for the treatment of severe hypertension and hypertensive crisis.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Heart Ventricles; Hemodynamics; Humans; Hypertension; Nifedipine; Verapamil | 1984 |
Effects of nicardipine, nifedipine, verapamil, and diltiazem on urine volume, sodium and potassium excretion and plasma aldosterone levels in the rat.
Topics: Aldosterone; Animals; Calcium Channel Blockers; Diltiazem; Kidney; Male; Natriuresis; Nicardipine; Nifedipine; Potassium; Rats; Rats, Inbred WKY; Urine; Verapamil | 1984 |
[The hypertensive crisis].
Topics: Acute Disease; Calcium Channel Blockers; Clonidine; Coronary Disease; Diazoxide; Dihydralazine; Diltiazem; Heart Failure; Humans; Hypertension; Nifedipine; Nitroprusside; Sympatholytics; Verapamil | 1984 |
Effects of organic Ca2+-antagonists on membrane characteristics of nodose ganglion cells in the rabbit.
Topics: Action Potentials; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane; Diltiazem; Membrane Potentials; Neurons; Nifedipine; Nodose Ganglion; Potassium; Rabbits; Vagus Nerve; Verapamil | 1984 |
Enhancement of cardioplegic myocardial protection with calcium entry blockers.
Topics: Calcium Channel Blockers; Diltiazem; Heart Arrest, Induced; Humans; Lidoflazine; Myocardium; Nifedipine; Organ Preservation; Verapamil | 1984 |
Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists.
Topics: Analgesics; Animals; Body Temperature Regulation; Calcium Channel Blockers; Diltiazem; Drug Synergism; Male; Morphine; Nociceptors; Rats; Rats, Inbred Strains; Verapamil | 1984 |
Renal interactions between norepinephrine and calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Glomerular Filtration Rate; Kidney; Male; Norepinephrine; Rats; Rats, Inbred Strains; Renal Circulation; Renal Veins; Vascular Resistance; Verapamil | 1984 |
Calcium channel antagonists in the treatment of asthma.
Topics: Airway Resistance; Animals; Asthma; Biological Transport; Calcium; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nifedipine; Verapamil | 1984 |
[Calcium antagonists: effect on peripheral and coronary hemodynamics].
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Coronary Disease; Coronary Vessels; Diltiazem; Heart Rate; Hemodynamics; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Vascular Resistance; Verapamil | 1984 |
Mechanism(s) of calcium antagonists and ischemia.
Topics: Adenosine Triphosphate; Angina Pectoris; Angina, Unstable; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Coronary Vasospasm; Diltiazem; Energy Metabolism; Hemodynamics; Humans; Myocardium; Nifedipine; Verapamil | 1984 |
Effects of diltiazem on atrioventricular conduction and arterial blood pressure: correlation with plasma drug concentrations.
Topics: Animals; Atrioventricular Node; Benzazepines; Blood Pressure; Diltiazem; Dogs; Heart Conduction System; Isoproterenol; Refractory Period, Electrophysiological; Verapamil | 1984 |
Antagonistic activity of verapamil and diltiazem against different intestinal smooth muscle stimuli.
Topics: Acetylcholine; Animals; Barium; Barium Compounds; Benzazepines; Chlorides; Common Bile Duct; Diltiazem; Duodenum; Female; Guinea Pigs; Histamine Antagonists; Ileum; In Vitro Techniques; Intestines; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Serotonin Antagonists; Verapamil | 1984 |
Calcium channel blockers. New treatment for cardiovascular disease.
Topics: Adult; Angina Pectoris; Calcium; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Cardiovascular Diseases; Diltiazem; Drug Administration Schedule; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Myocardial Contraction; Nifedipine; Verapamil | 1983 |
Calcium channel blockers for the treatment of coronary artery spasm: rationale, effects, and nursing responsibilities.
Topics: Calcium; Calcium Channel Blockers; Coronary Vasospasm; Coronary Vessels; Diltiazem; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Nifedipine; Verapamil | 1983 |
Mechanism of action and clinical use of Ca++-antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Electrophysiology; Heart Diseases; Humans; Muscles; Verapamil | 1983 |
Comparative effects of nifedipine, verapamil, and diltiazem on experimental pulmonary hypertension.
Topics: Animals; Benzazepines; Blood Pressure; Cardiac Output; Diltiazem; Dinoprost; Dogs; Dose-Response Relationship, Drug; Female; Hypertension, Pulmonary; Hypoxia; Male; Nifedipine; Prostaglandins F; Pulmonary Wedge Pressure; Pyridines; Vascular Resistance; Verapamil | 1983 |
Nifedipine, diltiazem, bepridil and verapamil uptakes into cardiac and smooth muscles.
Topics: Animals; Benzazepines; Bepridil; Calcium Channel Blockers; Cats; Chick Embryo; Diltiazem; Ileum; In Vitro Techniques; Muscle, Smooth; Myocardium; Nifedipine; Papillary Muscles; Pyridines; Pyrrolidines; Rabbits; Time Factors; Verapamil | 1983 |
Depression of contractions of rabbit aorta and guinea pig vena cava by mesudipine and other slow channel blockers.
Topics: Animals; Aorta, Thoracic; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Potassium; Pyridines; Pyrrolidines; Rabbits; Vena Cava, Inferior; Verapamil | 1983 |
Effects of five different organic calcium antagonists on guinea-pig isolated trachea.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicardipine; Nifedipine; Pyrrolidines; Trachea; Verapamil | 1984 |
[Effect of diltiazem on experimental cerebral vasospasm incomparison with effects of cinnarizine, verapamil and nifedipine].
Topics: Animals; Benzazepines; Blood Pressure; Cinnarizine; Diltiazem; Dogs; Dose-Response Relationship, Drug; Intracranial Pressure; Ischemic Attack, Transient; Nifedipine; Pulse; Verapamil | 1983 |
Effects of calcium channel blockers on isolated carotid baroreceptors and baroreflex.
Topics: Animals; Benzazepines; Blood Pressure; Calcium; Carotid Arteries; Carotid Sinus; Diltiazem; Dogs; Efferent Pathways; Heart; Heart Rate; Kinetics; Muscle Contraction; Muscle, Smooth; Nifedipine; Pressoreceptors; Reflex; Verapamil | 1983 |
Clinical use of calcium channel blockers.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Hemodynamics; Humans; Myocardial Contraction; Nifedipine; Verapamil | 1983 |
Comparative study of the effect of slow channel inhibiting agents on ischemia-induced conduction delay as relevant to the genesis of ventricular fibrillation.
Topics: Animals; Calcium Channel Blockers; Coronary Disease; Diltiazem; Dogs; Heart; Heart Conduction System; Male; Nifedipine; Ventricular Fibrillation; Verapamil | 1983 |
[Therapy of dyskinesia of Oddiś sphincter with calcium antagonists].
Topics: Adult; Ampulla of Vater; Biliary Dyskinesia; Calcium Channel Blockers; Cholecystectomy; Common Bile Duct Diseases; Diltiazem; Female; Humans; Nifedipine; Postoperative Complications; Sphincter of Oddi; Verapamil | 1983 |
Effects of calcium-antagonists on passive cutaneous anaphylaxis in the rat.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Gallopamil; Male; Nifedipine; Passive Cutaneous Anaphylaxis; Rats; Verapamil | 1983 |
The effect of calcium antagonists on contractions of the sensitized and normal guinea pig ileum.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; Histamine; Ileum; Muscle Contraction; Papaverine; Potassium Chloride; SRS-A; Verapamil | 1983 |
Calcium channel blocking agents. Council on scientific affairs.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Asthma; Calcium Channel Blockers; Cardiomyopathy, Hypertrophic; Diltiazem; Humans; Hypertension; Lung Diseases, Obstructive; Myocardial Infarction; Nifedipine; United States; United States Food and Drug Administration; Verapamil | 1983 |
Effects of diltiazem on vulnerability to atrial and ventricular reentrant arrhythmias in the normal and ischemic heart.
Topics: Animals; Arrhythmias, Cardiac; Benzazepines; Coronary Disease; Diltiazem; Dogs; Electrophysiology; Female; Male; Myocardial Infarction; Quinidine; Verapamil | 1983 |
Comparative effects of verapamil, diltiazem, and nifedipine on hemodynamics and left ventricular function during acute myocardial ischemia in dogs.
Topics: Animals; Benzazepines; Blood Pressure; Coronary Circulation; Coronary Disease; Diltiazem; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Nifedipine; Stroke Volume; Vascular Resistance; Verapamil | 1984 |
Comparison of calcium channel inhibitors on vagal heart rate responses elicited by arterial baroreceptor reflexes in anesthetized dogs.
Topics: Acetylcholine; Anesthesia; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Heart Rate; In Vitro Techniques; Male; Nicotinic Acids; Nifedipine; Nimodipine; Nitroprusside; Norepinephrine; Pressoreceptors; Reflex; Vagus Nerve; Verapamil | 1984 |
The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Survival; Chemotaxis, Leukocyte; Diltiazem; Gallopamil; Magnesium; Neutrophils; Perhexiline; Prenylamine; Rabbits; Verapamil | 1984 |
Beneficial hemodynamic effects of intravenous and oral diltiazem in severe congestive heart failure.
Topics: Administration, Oral; Adult; Benzazepines; Diltiazem; Female; Heart Failure; Heart Rate; Hemodynamics; Humans; Injections, Intravenous; Male; Middle Aged; Nifedipine; Verapamil | 1984 |
Temperature-dependent modulation of [3H]nitrendipine binding by the calcium channel antagonists verapamil and diltiazem in rat brain synaptosomes.
Topics: Animals; Benzazepines; Binding Sites; Brain; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Synaptosomes; Temperature; Tritium; Verapamil | 1984 |
The spontaneous occurrence of paroxysmal supraventricular tachycardia.
Topics: Adult; Diltiazem; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Monitoring, Physiologic; Probability; Recurrence; Sleep; Tachycardia, Paroxysmal; Telephone; Time Factors; Verapamil | 1984 |
In vivo effects of three calcium blockers on chickens with inherited muscular dystrophy.
Topics: Animals; Benzazepines; Calcium; Chickens; Creatine Kinase; Diltiazem; Disease Models, Animal; Female; Male; Motor Activity; Muscles; Muscular Dystrophies; Nifedipine; Verapamil | 1984 |
An inhibitory effect of verapamil and diltiazem on the release of noradrenaline from ischaemic and reperfused hearts.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzazepines; Coronary Disease; Diltiazem; Dopamine; Epinephrine; Heart; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Perfusion; Rats; Rats, Inbred Strains; Species Specificity; Verapamil | 1984 |
Effects of Ca antagonists on the norepinephrine release and contractile responses of isolated canine saphenous veins to transmural nerve stimulation.
Topics: Adrenergic Fibers; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Dogs; Electric Stimulation; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Endings; Nicardipine; Nifedipine; Norepinephrine; Saphenous Vein; Tritium; Verapamil | 1984 |
Prevention of reperfusion damage in working rat hearts by calcium antagonists and calmodulin antagonists.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calmodulin; Cardiac Output; Coronary Circulation; Coronary Disease; Diltiazem; L-Lactate Dehydrogenase; Male; Myocardium; Nifedipine; Perfusion; Phosphocreatine; Rats; Rats, Inbred Strains; Sulfonamides; Verapamil | 1984 |
Verapamil cardioplegia: improved myocardial preservation during global ischemia.
Topics: Adenosine Triphosphate; Animals; Constriction; Diltiazem; Dogs; Drug Evaluation; Heart Arrest, Induced; Hemodynamics; Lactates; Myocardium; Nifedipine; Oxygen; Perfusion; Phosphocreatine; Temperature; Verapamil | 1984 |
Comparative cardiovascular effects of verapamil, nifedipine, and diltiazem during halothane anesthesia in swine.
Topics: Anesthesia, General; Animals; Benzazepines; Blood Pressure; Calcium Chloride; Cardiac Output; Diltiazem; Halothane; Heart Rate; Hemodynamics; Nifedipine; Pulmonary Circulation; Stroke Volume; Swine; Vascular Resistance; Verapamil | 1984 |
Elevation of intraocular pressure by calcium channel blockers.
Topics: Administration, Oral; Administration, Topical; Animals; Aqueous Humor; Ascorbic Acid; Calcium Channel Blockers; Diltiazem; Eye; Humans; Intraocular Pressure; Male; Nifedipine; Rabbits; Time Factors; Verapamil | 1984 |
Calcium entry blocker activity of cyproheptadine in isolated cardiovascular preparations.
Topics: Animals; Calcium Channel Blockers; Cyproheptadine; Diltiazem; Female; Heart; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Papillary Muscles; Potassium Chloride; Rabbits; Rats; Rats, Inbred Strains; Verapamil | 1984 |
Mechanisms of slow contracture induced by potassium and caffeine in skeletal muscle of the dog.
Topics: Animals; Caffeine; Calcium Chloride; Chlorides; Diltiazem; Dogs; Kinetics; Manganese; Manganese Compounds; Muscle Contraction; Potassium; Potassium Chloride; Tetracaine; Verapamil | 1984 |
Pathophysiology and treatment of coronary arterial spasm.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Atropine; Calcium; Coronary Disease; Coronary Vessels; Diltiazem; Female; Humans; Male; Nifedipine; Nitroglycerin; Phenoxybenzamine; Physical Exertion; Propranolol; Spasm; Verapamil | 1980 |
Ergonovine testing to detect spontaneous remissions of variant angina during long-term treatment with calcium antagonist drugs.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium; Diltiazem; Ergonovine; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Middle Aged; Nifedipine; Remission, Spontaneous; Time Factors; Verapamil | 1981 |
Calcium entry blockers in cardiologic therapy.
Topics: Angina Pectoris, Variant; Calcium; Cardiovascular Agents; Diltiazem; Heart Diseases; Hemodynamics; Humans; Models, Biological; Muscle, Smooth, Vascular; Nifedipine; Vasoconstriction; Verapamil | 1981 |
Reflex chronotropic and inotropic effects of calcium channel-blocking agents in conscious dogs. Diltiazem, verapamil, and nifedipine compared.
Topics: Animals; Atropine; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Male; Myocardial Contraction; Nifedipine; Propranolol; Verapamil | 1983 |
Calcium channel blockers.
Topics: Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Half-Life; Heart Diseases; Humans; Hypertension; Kinetics; Myocardial Infarction; Nifedipine; Perhexiline; Vasodilator Agents; Verapamil | 1983 |
Calcium antagonist and the peripheral circulation: differences and similarities between PY 108-068, nicardipine, verapamil and diltiazem.
Topics: Animals; Calcium Channel Blockers; Cats; Diltiazem; Hemodynamics; Microspheres; Neural Conduction; Nicardipine; Nifedipine; Regional Blood Flow; Verapamil | 1983 |
Inhibition of platelet aggregation by diltiazem. Comparison with verapamil and nifedipine and inhibitory potencies of diltiazem metabolites.
Topics: Adenosine Diphosphate; Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Nifedipine; Platelet Aggregation; Pyridines; Rabbits; Stereoisomerism; Verapamil | 1983 |
Protection of infarcting myocardium by slow channel inhibitors. Comparative effects of verapamil, nifedipine, and diltiazem in the coronary-ligated, isolated working rat heart.
Topics: Animals; Benzazepines; Calcium Channel Blockers; Cardiac Pacing, Artificial; Coronary Circulation; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Contraction; Myocardial Infarction; Nifedipine; Pyridines; Rats; Verapamil | 1983 |
The comparative effects of diltiazem and verapamil on atrioventricular conduction and atrioventricular reentry tachycardia.
Topics: Adult; Atrioventricular Node; Benzazepines; Calcium Channel Blockers; Diltiazem; Female; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Tachycardia; Verapamil | 1983 |
Chronotropic, inotropic, and vasodilator actions of diltiazem, nifedipine, and verapamil. A comparative study of physiological responses and membrane receptor activity.
Topics: Animals; Benzazepines; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Guinea Pigs; Heart Rate; In Vitro Techniques; Myocardial Contraction; Nicotinic Acids; Nifedipine; Nimodipine; Potassium; Pyridines; Receptors, Drug; Vasodilation; Verapamil | 1983 |
Therapeutic uses of calcium channel blockers.
Topics: Angina Pectoris; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Humans; Hypertension; Infant; Muscle, Smooth; Nifedipine; Tachycardia; Verapamil | 1983 |
Study of the ventricular antifibrillatory effects of calcium channel blocking agents in comparison with lidocaine on canine normal heart in situ.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart; Heart Conduction System; Lidocaine; Male; Myocardial Contraction; Risk; Sinoatrial Node; Verapamil | 1983 |
Effect of calcium antagonists on leukotriene D4-induced contractions of the guinea-pig trachea and lung parenchyma.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Gallic Acid; Guinea Pigs; Lung; Male; Muscle Contraction; Muscle, Smooth; SRS-A; Trachea; Verapamil | 1983 |
Calcium antagonists in heart failure.
Topics: Aortic Valve Insufficiency; Calcium Channel Blockers; Coronary Disease; Diltiazem; Heart Failure; Hemodynamics; Humans; Hypertension, Pulmonary; Nifedipine; Verapamil | 1983 |
Ischemia-reperfusion induced elevation of diastolic tension in the isolated guinea pig heart and the effects of calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diastole; Diltiazem; Glycolysis; Guinea Pigs; Heart Rate; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Myocardial Contraction; Perfusion; Verapamil | 1983 |
Spontaneous remission is a frequent outcome of variant angina.
Topics: Adult; Angina Pectoris, Variant; Coronary Angiography; Coronary Vasospasm; Diltiazem; Electrocardiography; Ergonovine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Recurrence; Remission, Spontaneous; Time Factors; Verapamil | 1983 |
Diltiazem protects the isolated rabbit heart from the mechanical and ultrastructural damage produced by transient hypoxia, low-flow ischemia and exposure to Ca++-free medium.
Topics: Animals; Benzazepines; Calcium; Coronary Circulation; Diltiazem; Female; In Vitro Techniques; Male; Microscopy, Electron; Myocardial Contraction; Myocardium; Oxygen; Perfusion; Rabbits; Starvation; Verapamil | 1983 |
Effects of calcium antagonists on the electrical alternans of the ST segment and on associated mechanical alternans during acute coronary occlusion in dogs.
Topics: Acute Disease; Animals; Arterial Occlusive Diseases; Calcium Channel Blockers; Coronary Disease; Diltiazem; Dipyridamole; Dogs; Electrocardiography; Membrane Potentials; Myocardial Contraction; Nifedipine; Verapamil | 1983 |
Exaggerated hypotensive responses to calcium antagonists in spontaneously hypertensive rats.
Topics: Action Potentials; Animals; Arginine Vasopressin; Blood Pressure; Calcium Channel Blockers; Diltiazem; Female; Hypertension; Rats; Rats, Inbred Strains; Vasoconstriction; Verapamil | 1983 |
Vasodilator mechanism of KB-944, a new calcium antagonist.
Topics: Adenosine; Animals; Benzothiazoles; Calcium Channel Blockers; Calcium Chloride; Coronary Vessels; Diltiazem; Dogs; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium; Rabbits; Thiazoles; Vasodilator Agents; Verapamil | 1982 |
Antiarrhythmic effect of KB-944, a new calcium antagonist. A comparison with verapamil and diltiazem.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Benzothiazoles; Calcium Channel Blockers; Calcium Chloride; Diltiazem; Epinephrine; Guinea Pigs; Male; Ouabain; Rats; Thiazoles; Verapamil | 1982 |
Differential actions of calcium antagonists on calcium binding to cardiac sarcolemma.
Topics: Animals; Bepridil; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Guinea Pigs; In Vitro Techniques; Myocardium; Nifedipine; Pyrrolidines; Sarcolemma; Verapamil | 1982 |
Symposium on Cardiovascular Disease and Calcium Antagonists. Introduction.
Topics: Angina Pectoris; Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Humans; Myocardial Infarction; Nifedipine; Verapamil | 1982 |
The effects of calcium channel blocking agents on cardiovascular function.
Topics: Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Coronary Disease; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; Heart Failure; Heart Rate; Hemodynamics; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Vasodilation; Verapamil | 1982 |
Electrophysiologic effects of diltiazem in canine myocardium, with special reference to conduction delay during ischemia.
Topics: Animals; Atrioventricular Node; Benzazepines; Coronary Circulation; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Conduction System; Heart Rate; Heart Ventricles; Hemodynamics; Myocardium; Nifedipine; Oxygen Consumption; Verapamil | 1982 |
Comparative electrophysiologic and coronary hemodynamic effects of diltiazem, nisoldipine and verapamil on myocardial tissue.
Topics: Animals; Benzazepines; Bundle of His; Calcium Channel Blockers; Culture Techniques; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Atria; Heart Conduction System; Hemodynamics; Humans; Membrane Potentials; Nifedipine; Nisoldipine; Purkinje Fibers; Pyridines; Verapamil | 1982 |
Clinical characteristics of patients with variant angina complicated by myocardial infarction or death within 1 month.
Topics: Adult; Angina Pectoris, Variant; Coronary Disease; Coronary Vasospasm; Death, Sudden; Diltiazem; Electrocardiography; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nifedipine; Verapamil | 1982 |
Extracellular calcium concentration and calcium blocking agents on the action of ouabain on isolated rat atrium.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Electric Stimulation; Gallopamil; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Ouabain; Rats; Rats, Inbred Strains; Verapamil | 1982 |
The interaction of [3H]nitrendipine with receptors for calcium antagonists in the cerebral cortex and heart of rats.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Chloride; Cerebral Cortex; Diltiazem; Gallopamil; Kinetics; Lanthanum; Male; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Drug; Verapamil | 1982 |
Potentiation of indirectly induced muscle twitches by organic calcium antagonists in phrenic nerve-diaphragm muscle preparations of mice.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Gallopamil; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Stimulation, Chemical; Verapamil | 1982 |
Calcium ion blocking drugs.
Topics: Administration, Oral; Bradycardia; Calcium Channel Blockers; Diltiazem; Dizziness; Headache; Heart Diseases; Humans; Hypotension; Injections, Intravenous; Muscle, Smooth, Vascular; Nausea; Nifedipine; Tachycardia; Verapamil | 1982 |
Effect of Ca2+ blocking agents on the metabolism of low density lipoproteins in human skin fibroblasts.
Topics: Benzazepines; Calcium Channel Blockers; Dibucaine; Diltiazem; Fendiline; Fibroblasts; Gallopamil; Humans; Kinetics; Lipoproteins, LDL; Nifedipine; Phenethylamines; Prenylamine; Pyridines; Skin; Trifluoperazine; Verapamil | 1982 |
Calcium channel blockers in chronic stable angina. A review.
Topics: Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Diltiazem; Electrocardiography; Humans; Nicardipine; Nifedipine; Verapamil | 1982 |
Calcium channel blockers: indications and limitations 1. Clinical pharmacology and use as antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Biological Availability; Calcium; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Dose-Response Relationship, Drug; Heart Block; Humans; Hypotension; Nifedipine; Verapamil | 1982 |
Release of norepinephrine and dopamine from brain vesicular preparations: effects of calcium antagonists.
Topics: Animals; Benzazepines; Calcium; Cerebral Cortex; Corpus Striatum; Diltiazem; Dopamine; Gallopamil; Guinea Pigs; Kinetics; Male; Norepinephrine; Potassium; Verapamil | 1982 |
Effects of calcium antagonists, especially nifedipine, on variant angina, resting angina, and unstable angina.
Topics: Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Vasospasm; Diltiazem; Female; Humans; Male; Middle Aged; Nifedipine; Perhexiline; Prenylamine; Pyridines; Rest; Verapamil | 1982 |
Effect of Ca2+-antagonistic vasodilators, diltiazem, nifedipine, perhexiline and verapamil, on platelet aggregation in vitro.
Topics: Adenosine Diphosphate; Adolescent; Adult; Calcium; Collagen; Diltiazem; Epinephrine; Humans; In Vitro Techniques; Male; Nifedipine; Perhexiline; Platelet Aggregation; Vasodilator Agents; Verapamil | 1981 |
Effects of calcium antagonists and lidocaine on conduction delay induced by acute myocardial ischemia in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Coronary Disease; Diltiazem; Dogs; Heart Conduction System; Lidocaine; Time Factors; Verapamil | 1980 |
Effect of calcium antagonists on the electrical alternans of the ST segment during acute coronary occlusion in dogs.
Topics: Acute Disease; Animals; Calcium; Coronary Disease; Diltiazem; Dipyridamole; Dogs; Electrocardiography; Verapamil | 1981 |
Inhibitory action of calcium antagonists on ATP-dependent calcium uptake by the renal cortical microsomes.
Topics: Adenosine Triphosphate; Animals; Benzazepines; Calcium; Depression, Chemical; Diltiazem; In Vitro Techniques; Kidney Cortex; Male; Microsomes; Rats; Verapamil | 1980 |
Provocative testing with ergonovine to assess the efficacy of treatment with nifedipine, diltiazem and verapamil in variant angina.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Benzazepines; Coronary Angiography; Diltiazem; Electrocardiography; Ergonovine; Female; Follow-Up Studies; Humans; Male; Middle Aged; Nifedipine; Pyridines; Verapamil | 1981 |
Blood flow in normal and acutely ischemic myocardium after verapamil, diltiazem and nisoldipine (Bay k 5552), a new dihydropyridine calcium antagonist.
Topics: Animals; Benzazepines; Calcium; Coronary Circulation; Coronary Disease; Diltiazem; Dogs; Female; Hemodynamics; Male; Nifedipine; Nisoldipine; Pyridines; Verapamil | 1981 |
Inhibitory effect on calcium channel blockers on alpha -adrenergic activation of glycogenolysis and calcium efflux in perfused rat liver.
Topics: Animals; Benzazepines; Calcium; Calcium Channel Blockers; Diltiazem; Glucose; Liver; Liver Glycogen; Male; Mitochondria, Liver; Phenylephrine; Rats; Verapamil | 1981 |
Diltiazem and verapamil inhibit norepinephrine-stimulated 45Ca uptake in rabbit aorta.
Topics: Animals; Aorta; Benzazepines; Calcium; Diltiazem; Male; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Verapamil | 1981 |
Calcium antagonists.
Topics: Angina Pectoris; Calcium Channel Blockers; Cell Membrane; Diltiazem; Heart; Humans; Hypertension; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Infarction; Myocardium; Nifedipine; Perhexiline; Verapamil | 1980 |
Therapeutic uses of calcium-blocking agents:verapamil, nifedipine, and diltiazem.
Topics: Benzazepines; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Humans; Nifedipine; Pyridines; Verapamil | 1981 |
Protective effects on verapamil and diltiazem against inorganic phosphate induced impairment of oxidative phosphorylation of isolated heart mitochondria.
Topics: Animals; Benzazepines; Diltiazem; Female; In Vitro Techniques; Male; Mitochondria, Heart; Osmolar Concentration; Oxidative Phosphorylation; Oxygen Consumption; Phosphates; Potassium Chloride; Rabbits; Temperature; Verapamil | 1981 |
Clinical use of calcium entry blockers.
Topics: Angina Pectoris; Calcium Channel Blockers; Cinnarizine; Coronary Circulation; Coronary Vasospasm; Diltiazem; Flunarizine; Heart Rate; Humans; Lidoflazine; Nifedipine; Perhexiline; Verapamil | 1981 |
Effects of calcium antagonists on the alternation of the ST-T complex and associated conduction abnormalities during coronary occlusion in dogs.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Coronary Disease; Diltiazem; Dipyridamole; Dogs; Electrocardiography; Heart Conduction System; Verapamil | 1981 |
Calcium blockers in coronary heart disease. Part II.
Topics: Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Vasospasm; Diltiazem; Humans; Nifedipine; Verapamil | 1981 |
Cardiovascular protection by Ca antagonists.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Coronary Vasospasm; Diltiazem; Hypertension; In Vitro Techniques; Muscle, Smooth, Vascular; Nifedipine; Rabbits; Rats; Swine; Verapamil | 1980 |
[Calcium inhibitors. Current indications in cardiology].
Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium; Cardiovascular Diseases; Diltiazem; Humans; Nifedipine; Perhexiline; Prenylamine; Verapamil | 1980 |
Calcium antagonistic drugs. Mechanism of action.
Topics: Animals; Benzazepines; Calcium; Cardiovascular System; Cell Membrane; Diltiazem; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Myocardial Contraction; Nifedipine; Pyridines; Rabbits; Rats; Verapamil | 1980 |
Effects of nifedipine, diltiazem and verapamil on the vasoconstrictor responses to norepinephrine and potassium ions in the rat mesenteric artery.
Topics: Animals; Benzazepines; Diltiazem; Drug Interactions; In Vitro Techniques; Male; Mesenteric Arteries; Nifedipine; Norepinephrine; Potassium; Pyridines; Rats; Vasoconstriction; Verapamil | 1980 |
Refractory variant angina controlled with combined drug therapy in a patient with a single coronary artery.
Topics: Adult; Angina Pectoris; Angina Pectoris, Variant; Angiocardiography; Arteries; Coronary Vessel Anomalies; Diltiazem; Drug Therapy, Combination; Humans; Male; Nifedipine; Verapamil | 1980 |
Comparative effects of three calcium antagonists, diltiazem, verapamil and nifedipine, on the sinoatrial and atrioventricular nodes. Experimental and clinical studies.
Topics: Adolescent; Adult; Aged; Animals; Atrioventricular Node; Benzazepines; Calcium; Diltiazem; Electric Stimulation; Female; Humans; Male; Middle Aged; Nifedipine; Pyridines; Rabbits; Sinoatrial Block; Sinoatrial Node; Verapamil | 1981 |
A comparative study of calcium-ion antagonists in patients with variant angina.
Topics: Adult; Aged; Angina Pectoris; Angina Pectoris, Variant; Benzazepines; Diltiazem; Electrocardiography; Ergonovine; Female; Heart; Humans; Male; Middle Aged; Nifedipine; Pyridines; Verapamil | 1980 |
Cardioprotective effects of calcium ion antagonists in myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Benzazepines; Biological Transport, Active; Calcium; Coronary Disease; Diltiazem; In Vitro Techniques; Male; Microscopy, Electron; Myocardium; Nifedipine; Pyridines; Rabbits; Time Factors; Verapamil | 1980 |
Modulation of acetylcholine release in rat hippocampus by amino alcohols and Bay K 8644.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium; Cerebral Cortex; Choline; Corpus Striatum; Diltiazem; Dose-Response Relationship, Drug; Ethanolamine; Ethanolamines; Flunarizine; Hippocampus; In Vitro Techniques; Male; Nifedipine; Osmolar Concentration; Potassium Chloride; Propanolamines; Pyrrolidines; Rats; Rats, Inbred F344; Verapamil | 1993 |
Effect of calcium antagonists on RNA synthesis of NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Biological Transport; Calcium Channel Blockers; Culture Media; Diltiazem; Kinetics; Mice; Nifedipine; RNA; Uridine; Verapamil | 1993 |
Calcium channels in vitamin B6 deficiency-induced hypertension.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Diltiazem; Hypertension; Male; Nicotinic Acids; Nifedipine; Oxadiazoles; Rats; Rats, Sprague-Dawley; Verapamil; Vitamin B 6 Deficiency | 1993 |
Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Behavior, Animal; Calcium Channels; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Implants; Female; Ileum; In Vitro Techniques; Isomerism; Mice; Muscle Contraction; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Verapamil; Yohimbine | 1993 |
Effect of calcium channel blockers on the growth of human vascular smooth muscle cells derived from saphenous vein and vascular graft stenoses.
Topics: Amlodipine; Cell Division; Cells, Cultured; Diltiazem; DNA; Graft Occlusion, Vascular; Humans; L-Lactate Dehydrogenase; Muscle, Smooth, Vascular; Saphenous Vein; Verapamil | 1994 |
Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzimidazoles; Calcium Channel Blockers; Calmodulin; Cell Adhesion Molecules; Cells, Cultured; Diltiazem; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Mibefradil; Piperazines; Protein Kinase C; Sulfonamides; Tetrahydronaphthalenes; Umbilical Veins; Vascular Cell Adhesion Molecule-1; Verapamil | 1994 |
Mitochondrial calcium uptake stimulated by Cibacron blue F3GA in bovine sperm.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cations, Divalent; Cattle; Diltiazem; Glucose; Kinetics; Male; Metals; Mitochondria; Nifedipine; Oligomycins; Protein Synthesis Inhibitors; Rotenone; Ruthenium Red; Spermatozoa; Triazines; Verapamil | 1995 |
Diltiazem and superoxide dismutase modulate hepatic acute phase response in gram-negative sepsis.
Topics: Acute-Phase Proteins; Acute-Phase Reaction; Animals; Bacteroides fragilis; Bacteroides Infections; Blood Proteins; Calcium; Carcinoma, Hepatocellular; Diltiazem; Escherichia coli Infections; Gene Expression Regulation; Gram-Negative Bacterial Infections; Interleukin-1; Interleukin-6; Liver; Liver Neoplasms; Male; Neoplasm Proteins; Peritonitis; Rats; Rats, Sprague-Dawley; Sepsis; Superoxide Dismutase; Tumor Cells, Cultured; Verapamil | 1994 |
Effects of Ca2+ channel antagonist subtypes on mitochondrial Ca2+ transport.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Cattle; Diltiazem; Flunarizine; In Vitro Techniques; Mitochondria; Nitrendipine; Verapamil | 1995 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cadmium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Isradipine; Neuroblastoma; Neurons; Nicotine; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Receptors, Nicotinic; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1995 |
Protective effect of some calcium antagonists against mitochondrial calcium injury.
Topics: Adenosine Triphosphate; Amlodipine; Animals; Antihypertensive Agents; Bepridil; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Mitochondria, Liver; Myocardial Ischemia; Nicardipine; Rats; Rats, Wistar; Verapamil | 1994 |
Protective effects of calcium channel blockers on acute bromobenzene toxicity to isolated rat hepatocytes. Inhibition of phenylephrine-induced calcium oscillations.
Topics: Animals; Bromobenzenes; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Egtazic Acid; Female; L-Lactate Dehydrogenase; Liver; Nifedipine; Phenylephrine; Rats; Rats, Sprague-Dawley; Verapamil | 1995 |
[Effects of calcium channel blockers on electrical and mechanical responses of rat phrenic nerve-diaphragm preparations].
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Muscle, Skeletal; Phrenic Nerve; Physical Stimulation; Prenylamine; Rats; Rats, Wistar; Verapamil | 1995 |
Calcium channel blockers for heart rate control in atrial fibrillation complicated by congestive heart failure.
Topics: Atrial Fibrillation; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Female; Heart Failure; Hemodynamics; Humans; Male; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Systole; Ventricular Dysfunction, Left; Verapamil | 1995 |
Effects of diltiazem and verapamil on ADP-induced rabbit platelet shape change and aggregation.
Topics: Adenosine Diphosphate; Animals; Blood Platelets; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Male; Platelet Aggregation; Rabbits; Verapamil | 1995 |
Resolution and pharmacological analysis of the voltage-dependent calcium channels of Drosophila larval muscles.
Topics: Amiloride; Animals; Calcium Channels; Dihydropyridines; Diltiazem; Drosophila melanogaster; Electrophysiology; Larva; Verapamil | 1995 |
Verapamil or diltiazem for acute rate control: which is best.
Topics: Atrial Fibrillation; Atrial Flutter; Diltiazem; Heart Rate; Humans; Verapamil | 1995 |
The effect of calcium channel antagonists and BAY K 8644 on calcium fluxes of malignant hyperpyrexia-susceptible muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscles; Nifedipine; Potassium Chloride; Sarcoplasmic Reticulum; Swine; Verapamil | 1993 |
Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Bucladesine; Cell Differentiation; Cell Membrane; Diltiazem; Glioma; Hybrid Cells; Isradipine; Mollusk Venoms; Neuroblastoma; Nitrendipine; omega-Conotoxin GVIA; Potassium Chloride; Rats; Tumor Cells, Cultured; Verapamil | 1993 |
Comparison of a calcium antagonist, CD-349, with nifedipine, diltiazem, and verapamil in rabbit spontaneously beating sinoatrial node cells.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Electrophysiology; Female; In Vitro Techniques; Male; Microelectrodes; Nifedipine; Rabbits; Sinoatrial Node; Verapamil | 1993 |
Membrane stretch evoked by cell swelling increases contractile activity in vascular smooth muscle through dihydropyridine-sensitive pathways.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Membrane; Cell Size; Dihydropyridines; Diltiazem; Felodipine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Osmosis; Portal Vein; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Verapamil | 1994 |
Effect of nifedipine, verapamil and diltiazem on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Induction; Male; Nifedipine; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Verapamil | 1995 |
An intravascular ultrasound study of the influence of angiotensin-converting enzyme inhibitors and calcium entry blockers on the development of cardiac allograft vasculopathy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Captopril; Coronary Disease; Diltiazem; Enalapril; Female; Heart Transplantation; Humans; Hyperplasia; Lisinopril; Male; Middle Aged; Nifedipine; Transplantation, Homologous; Tunica Intima; Ultrasonography, Interventional; Verapamil | 1995 |
Comparison of various calcium channel blockers on guinea-pig isolated common bile duct.
Topics: Animals; Calcium Channel Blockers; Common Bile Duct; Dantrolene; Diltiazem; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Nifedipine; Verapamil | 1994 |
Comparison of the frequency-dependent effects on the atrioventricular node of verapamil, amiodarone, digoxin, and diltiazem in isolated guinea pig hearts.
Topics: Amiodarone; Animals; Atrioventricular Node; Cardiac Pacing, Artificial; Computer Simulation; Digoxin; Diltiazem; Electric Stimulation; Electrocardiography; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Verapamil | 1995 |
Investigation and optimisation of the use of micellar electrokinetic chromatography for the analysis of six cardiovascular drugs.
Topics: Amlodipine; Atenolol; Cardiovascular Agents; Chromatography; Diltiazem; Electrochemistry; Hydrogen-Ion Concentration; Kinetics; Micelles; Nicardipine; Nifedipine; Osmosis; Sodium Dodecyl Sulfate; Verapamil | 1995 |
ACLS rapid rate conversion drugs.
Topics: Adenosine; Diltiazem; Education, Nursing, Continuing; Emergency Nursing; Humans; Tachycardia; Teaching Materials; Verapamil | 1995 |
The effects of calcium antagonists and prostaglandin E1 on isolated canine coronary arterial tension.
Topics: Alprostadil; Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Data Interpretation, Statistical; Diltiazem; Dogs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Potassium; Sodium; Solutions; Verapamil | 1994 |
Antioxidant activity of calcium channel blocking drugs.
Topics: Animals; Antioxidants; Aorta; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Diltiazem; Dogs; Endothelium, Vascular; Free Radicals; Glutathione; Heart Ventricles; Isomerism; Kinetics; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Nifedipine; Sarcolemma; Verapamil | 1994 |
Adverse Drug Reactions Advisory Committee. Gynaecomastia in association with calcium antagonists.
Topics: Adult; Aged; Calcium Channel Blockers; Diltiazem; Felodipine; Gynecomastia; Humans; Male; Middle Aged; Nifedipine; Verapamil | 1994 |
Differential potentiation by depolarization of the effects of calcium antagonists on contraction and Ca2+ current in guinea-pig heart.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Polarity; Diltiazem; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Myocardial Contraction; Myocardium; Nifedipine; Papillary Muscles; Potassium; Verapamil | 1994 |
Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients.
Topics: Administration, Oral; Adult; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Graft Survival; Humans; Immunosuppression Therapy; Infusions, Intravenous; Kidney; Kidney Transplantation; Male; Middle Aged; Nifedipine; Nova Scotia; Retrospective Studies; Time Factors; Verapamil | 1994 |
Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cocaine; Conditioning, Psychological; Diltiazem; Heart Rate; Male; Nimodipine; Saimiri; Self Administration; Verapamil | 1995 |
Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: effect of drugs with different molecular mechanisms.
Topics: Allopurinol; Animals; Antioxidants; Brain Ischemia; Deferoxamine; Diltiazem; Lipid Peroxidation; Male; Rats; Rats, Wistar; Reperfusion; Reperfusion Injury; Verapamil; Vitamin E | 1994 |
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells, Cultured; Cholecalciferol; Cholesterol; Coronary Vessels; Diltiazem; Disease Models, Animal; Humans; Hypertension; Middle Aged; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Risk Factors; Verapamil | 1994 |
Verapamil decreases P-glycoprotein expression in multidrug-resistant human leukemic cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Diltiazem; Drug Resistance; Humans; Leukemia; Membrane Glycoproteins; Neoplasm Proteins; Nifedipine; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Calcium mobilization induced by endothelins and sarafotoxin in cultured canine tracheal smooth muscle cells.
Topics: Animals; Calcium; Carbachol; Cells, Cultured; Diltiazem; Dogs; Endothelin Receptor Antagonists; Endothelins; Female; Male; Muscle, Smooth; Peptides, Cyclic; Trachea; Vasoconstrictor Agents; Verapamil; Viper Venoms | 1994 |
In vitro antioxidant activity of calcium antagonists against LDL oxidation compared with alpha-tocopherol.
Topics: Adult; Amlodipine; Antioxidants; Calcium Channel Blockers; Copper; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Humans; Isradipine; Lipoproteins, LDL; Oxidation-Reduction; Reference Values; Thiobarbituric Acid Reactive Substances; Verapamil; Vitamin E | 1994 |
[The effects of calcium antagonists on prostaglandin E2 reaction in rabbit eyes].
Topics: Animals; Aqueous Humor; Calcium Channel Blockers; Diltiazem; Dinoprostone; Eye; Eye Proteins; Intraocular Pressure; Male; Nicardipine; Rabbits; Verapamil | 1994 |
Clinical significance and predisposing factors to symptomatic bradycardia and hypotension after percutaneous transluminal coronary angioplasty.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angioplasty, Balloon, Coronary; Bradycardia; Coronary Disease; Diltiazem; Female; Humans; Hypotension; Incidence; Male; Middle Aged; Risk Factors; Verapamil | 1994 |
Bradykinin-stimulated calcium mobilization in cultured canine tracheal smooth muscle cells.
Topics: Animals; Bradykinin; Calcium; Carbachol; Cells, Cultured; Diltiazem; Dogs; Dose-Response Relationship, Drug; Egtazic Acid; Female; Fura-2; Kallidin; Male; Muscle, Smooth; Trachea; Verapamil | 1994 |
Relation between blood pressure and plasma catecholamine concentration after administration of calcium antagonists to rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Catecholamines; Diltiazem; Heart Rate; Nicardipine; Rats; Rats, Sprague-Dawley; Verapamil | 1994 |
Thermosensitization and modification of cytosolic calcium concentration by verapamil and diltiazem in mouse mammary carcinoma cells.
Topics: Animals; Calcium; Cytosol; Diltiazem; Hot Temperature; Mammary Neoplasms, Experimental; Mice; Tumor Cells, Cultured; Verapamil | 1994 |
Inhibition by anti-malarial drugs of haemoglobin denaturation and iron release in acidified red blood cell lysates--a possible mechanism of their anti-malarial effect?
Topics: Animals; Antimalarials; Ascorbic Acid; Diltiazem; Dose-Response Relationship, Drug; Erythrocytes; Heme; Hemoglobins; Humans; Hydrogen-Ion Concentration; Iron; Plasmodium falciparum; Quinolines; Verapamil | 1994 |
Inhibitor effects of diltiazem, nicardipine, nifedipine and verapamil on the norepinephrine-induced contractions of the canine saphenous vein in calcium-free medium.
Topics: Animals; Calcium; Calcium Channel Blockers; Culture Media; Diltiazem; Dogs; Electrophysiology; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Norepinephrine; Saphenous Vein; Verapamil | 1994 |
Characterization of and the influence of calcium channel blockers on the renal excretion of pyrimidine anticancer agents.
Topics: Absorption; Animals; Biological Transport; Blood Proteins; Calcium Channels; Carrier Proteins; Chromatography, High Pressure Liquid; Diltiazem; Floxuridine; Fluorouracil; Inulin; Kidney; Male; Membrane Proteins; Mice; Monosaccharide Transport Proteins; Nucleoside Transport Proteins; Verapamil | 1994 |
Toxic effects of diltiazem in a patient with chronic renal failure.
Topics: Acidosis; Adult; Diltiazem; Heart Failure; Humans; Hyperkalemia; Hypotension; Kidney Failure, Chronic; Male; Verapamil | 1994 |
The effect of Ca2+ antagonists on spontaneous motility from sheep duodenum.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Duodenum; Gallic Acid; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nifedipine; Sheep; Trifluoperazine; Verapamil | 1994 |
Direct recording of EDP-EDV relationship in isolated rat left ventricle: effect of diastolic crossbridge formation.
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Diacetyl; Diastole; Diltiazem; Heart Ventricles; Nifedipine; Perfusion; Rats; Rats, Inbred WKY; Stroke Volume; Ventricular Function, Left; Verapamil | 1994 |
[Effects of calcium blockers and calmodulin inhibitors on the proliferation of fibroblast in alveolar macrophage condition medium].
Topics: Bronchoalveolar Lavage Fluid; Carcinoma, Bronchogenic; Cell Division; Chlorpromazine; Culture Media, Conditioned; Diltiazem; Fibroblasts; Humans; Lung Neoplasms; Macrophages, Alveolar; Pulmonary Fibrosis; Sarcoidosis; Verapamil | 1993 |
Involvement of Ca(2+)-stimulated adenosine 5'-triphosphatase in the Ca2+ releasing mechanism of rat liver nuclei.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Cell Nucleus; Diltiazem; Liver; Male; Rats; Rats, Wistar; Verapamil | 1994 |
[Anticonvulsant activity of sodium valproate and various calcium antagonists during their combined use in mice].
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Epilepsy; Male; Mice; Nifedipine; Valproic Acid; Verapamil | 1993 |
Inhibition of signal Ca2+ in dog coronary arterial vascular muscle cells by Ro 40-5967.
Topics: Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Cells, Cultured; Coronary Vessels; Diltiazem; Dogs; Fluorometry; Mibefradil; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Norepinephrine; Potassium; Rats; Tetrahydronaphthalenes; Verapamil | 1994 |
1-Benzazepin-2-one calcium channel blockers--VI. Receptor-binding model and possible relationship to desmethoxyverapamil.
Topics: Animals; Antihypertensive Agents; Benzazepines; Binding Sites; Calcium Channel Blockers; Calcium Channels; Diltiazem; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Muscle Contraction; Rabbits; Structure-Activity Relationship; Verapamil | 1993 |
Intervention of two voltage-dependent calcium-entry pathways in the contractile response to acetylcholine and KCl in rat uterus.
Topics: Acetylcholine; Animals; Calcium; Calcium Channels; Diltiazem; Dose-Response Relationship, Drug; Female; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Potassium Chloride; Rats; Rats, Wistar; Uterine Contraction; Uterus; Verapamil | 1994 |
L-type voltage-dependent calcium channels do not modulate aminergic neurotransmitter release induced by transient global cerebral ischaemia: an in vivo microdialysis study in rat.
Topics: Animals; Biogenic Monoamines; Biological Availability; Calcium Channels; Corpus Striatum; Dialysis; Diltiazem; Injections; Ischemic Attack, Transient; Male; Neurotransmitter Agents; Nimodipine; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
Cholinergic neuromuscular transmission in the longitudinal muscle of the guinea-pig ileum.
Topics: Action Potentials; Animals; Calcium; Cholinergic Fibers; Diltiazem; Electric Stimulation; Electrophysiology; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Nicardipine; Potassium; Synaptic Transmission; Verapamil | 1993 |
[Effects of calcium antagonists on prostaglandin E2 production in cultured human amnion cells].
Topics: Amnion; Calcium Channel Blockers; Cells, Cultured; Depression, Chemical; Diltiazem; Dinoprostone; Dose-Response Relationship, Drug; Egtazic Acid; Female; Humans; Interleukin-1; Nicardipine; Nifedipine; Phospholipases A; Phospholipases A2; Pregnancy; Verapamil | 1994 |
Modulation of cyclic AMP-dependent protein kinase activity by drugs affecting human platelet aggregation.
Topics: Aspirin; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Diltiazem; Humans; Kinetics; Masoprocol; Platelet Aggregation; Theophylline; Verapamil | 1993 |
[Comments on the contribution by G. F. Hauf and H. Roskamm. Heart failure in coronary heart disease].
Topics: Diltiazem; Heart Failure; Humans; Myocardial Infarction; Survival Rate; Verapamil | 1994 |
IGF-I mediates the stimulatory effect of high calcium concentration on osteoblastic cell proliferation.
Topics: 3T3 Cells; Animals; Antibodies; Calcium; Calcium Channel Blockers; Cell Division; Clone Cells; Cycloheximide; Dantrolene; Diltiazem; DNA; Dose-Response Relationship, Drug; Insulin-Like Growth Factor I; Kinetics; Magnesium; Mice; Nifedipine; Osteoblasts; Receptor, IGF Type 1; Transcription, Genetic; Verapamil | 1994 |
Are all calcium antagonists equally effective for reducing reinfarction rate?
Topics: Adult; Aged; Diltiazem; Humans; Hypertension; Middle Aged; Myocardial Infarction; Proportional Hazards Models; Recurrence; Verapamil | 1993 |
Potentiation of antinociceptive effects of morphine by calcium-channel blockers at the level of the spinal cord.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Injections, Spinal; Male; Morphine; Nicardipine; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Verapamil | 1993 |
In vitro characterization of a novel Ca2+ entry blocker: SR 33805.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Diltiazem; Heart Rate; In Vitro Techniques; Indoles; Indolizines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardium; Nifedipine; Phenethylamines; Rabbits; Radioligand Assay; Rats; Rats, Wistar; Sarcolemma; Sulfones; Verapamil | 1993 |
Calcium channel blockers apparently decrease noradrenaline release from nerve-skin terminals in Caudiverbera caudiverbera.
Topics: Amiloride; Animals; Anura; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Electric Stimulation; Electrophysiology; In Vitro Techniques; Membrane Potentials; Nerve Endings; Nifedipine; Norepinephrine; Skin; Skin Physiological Phenomena; Synapses; Verapamil | 1993 |
Reduction of capsaicin-induced ocular pain and neurogenic inflammation by calcium antagonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Capsaicin; Cornea; Diltiazem; Dose-Response Relationship, Drug; Keratitis; Neuritis; Nifedipine; Nociceptors; Pain; Rabbits; Verapamil | 1993 |
Azidobutyryl clentiazem, a new photoactivatable diltiazem analog, labels benzothiazepine binding sites in the alpha 1 subunit of the skeletal muscle calcium channel.
Topics: Affinity Labels; Animals; Azides; Benzodiazepines; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cattle; Diltiazem; Muscles; Precipitin Tests; Rabbits; Verapamil | 1993 |
Calcium channel blockers inhibit hydrogen peroxide-induced proliferation of cultured rat mesangial cells.
Topics: Animals; Calcium Channel Blockers; Cell Count; Cell Division; Cells, Cultured; Diltiazem; Diterpenes; Ginkgolides; Glomerular Mesangium; Hydrogen Peroxide; Kinetics; Lactones; Platelet Activating Factor; Platelet-Derived Growth Factor; Rats; Rats, Wistar; Thrombin; Thymidine; Tritium; Verapamil | 1993 |
Effects of verapamil and diltiazem on dopamine release in the central nervous system of spontaneously hypertensive rats.
Topics: Animals; Corpus Striatum; Diltiazem; Dopamine; Electric Stimulation; Hypertension; In Vitro Techniques; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Verapamil | 1993 |
Effects of calcium antagonists on insulin-mediated glucose metabolism in skeletal muscle.
Topics: Animals; Calcium Channel Blockers; Carbon Radioisotopes; Cyclic AMP; Diltiazem; Dose-Response Relationship, Drug; Glucose; Glycogen; Glycolysis; In Vitro Techniques; Insulin; Isoproterenol; Kinetics; Lactates; Male; Muscles; Nifedipine; Rats; Rats, Wistar; Verapamil | 1994 |
Effect of leukocyte adhesion and microvascular permeability on capillary perfusion during ischemia-reperfusion injury in hamster cheek pouch.
Topics: Adenosine; Allopurinol; Animals; Capillary Permeability; Cell Adhesion; Cheek; Cricetinae; Diltiazem; Leukocytes; Male; Mesocricetus; Perfusion; Pyrazoles; Reperfusion Injury; Verapamil | 1993 |
Effect of hyperkalemia on myocardial depression by verapamil in isolated hearts.
Topics: Animals; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Female; Guinea Pigs; Heart; Hyperkalemia; In Vitro Techniques; Male; Nifedipine; Verapamil | 1993 |
Calcium channel antagonists. What do the second-generation agents have to offer?
Topics: Arteriosclerosis; Calcium Channel Blockers; Cardiovascular Diseases; Cerebrovascular Disorders; Dihydropyridines; Diltiazem; Heart Failure; Humans; Verapamil | 1994 |
Intravenous diltiazem hydrochloride rather than verapamil for resistant paroxysmal supraventricular tachycardia.
Topics: Diltiazem; Drug Tolerance; Humans; Hypotension; Injections, Intravenous; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil | 1993 |
[Paroxysmal atrial fibrillation and flutter and "occult" arterial hypertension. The importance of the ambulatory monitoring of the blood pressure. Apropos 2 cases].
Topics: Atenolol; Atrial Fibrillation; Atrial Flutter; Blood Pressure Monitors; Diltiazem; Drug Therapy, Combination; Humans; Hypertension; Lisinopril; Male; Middle Aged; Verapamil | 1993 |
Ca2+ channel antagonists enhance tension in skinned skeletal and heart muscle fibres.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Freeze Drying; Heart; Humans; Muscle Contraction; Muscles; Myocardial Contraction; Nifedipine; Rabbits; Rats; Stimulation, Chemical; Troponin; Troponin C; Verapamil | 1993 |
Effects of calcium chloride on verapamil- and diltiazem-pretreated isolated rat hearts.
Topics: Animals; Atrioventricular Node; Atropine; Calcium; Calcium Chloride; Depression, Chemical; Diltiazem; Drug Interactions; Electrocardiography; Heart; Heart Block; Heart Rate; Male; Rats; Rats, Wistar; Ventricular Function, Left; Ventricular Pressure; Verapamil | 1993 |
Role of calcium in mediating the biphasic contraction of the rabbit urinary bladder.
Topics: Adenosine Triphosphate; Animals; Atropine; Bethanechol Compounds; Calcium; Diltiazem; Electric Stimulation; Extracellular Space; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Urinary Bladder; Verapamil | 1993 |
In vitro and in vivo electrocardiographic evaluation of the novel calcium antagonist monatepil on cardiac conduction system.
Topics: Anesthesia; Animals; Blood Pressure; Bundle of His; Calcium Channel Blockers; Dibenzothiepins; Diltiazem; Dogs; Electrocardiography; Female; Heart; Heart Conduction System; Heart Rate; Hypertension; In Vitro Techniques; Male; Nifedipine; Piperazines; Rabbits; Verapamil | 1993 |
Verapamil and diltiazem inhibit receptor-operated calcium channels and intracellular calcium oscillations in rat hepatocytes.
Topics: Animals; Calcium; Calcium Channels; Diltiazem; Fluorescent Dyes; Fura-2; Liver; Male; Manganese; Phenylephrine; Rats; Rats, Wistar; Receptors, Cell Surface; Vasopressins; Verapamil | 1993 |
Effect of calcium antagonists on endothelin-induced contraction of isolated human resistance arteries: differences related to site of origin.
Topics: Adipose Tissue; Adult; Aged; Arteries; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endothelins; Flunarizine; Humans; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Nimodipine; Nisoldipine; Omentum; Vasoconstriction; Verapamil | 1993 |
Calciseptine binding to a 1,4-dihydropyridine recognition site of the L-type calcium channel of rat synaptosomal membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Cell Fractionation; Dihydropyridines; Diltiazem; Elapid Venoms; Intracellular Membranes; Kinetics; Ligands; Male; Nitrendipine; omega-Conotoxins; Peptides; Rats; Rats, Wistar; Synaptosomes; Verapamil | 1993 |
Effects of nicorandil on cell proliferation and cholesteryl ester accumulation in arterial smooth muscle cells in culture.
Topics: Animals; Aorta, Thoracic; Calcium Channels; Cell Division; Cells, Cultured; Cholesterol; Cholesterol Esters; Diltiazem; DNA; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1993 |
A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.
Topics: Alkaloids; Animals; Benzylisoquinolines; Binding, Competitive; Calcium Channel Blockers; Cell Line; Decanoic Acids; Dihydropyridines; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Piperidines; Polypropylenes; Rabbits; Swine; Verapamil | 1993 |
Forskolin stimulates porcine sperm capacitation by increasing calcium uptake.
Topics: Acrosome; Animals; Biological Transport; Calcium; Colforsin; Diltiazem; In Vitro Techniques; Male; Sperm Capacitation; Swine; Verapamil | 1993 |
A one-year evaluation of calcium channel blocker overdoses: toxicity and treatment.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atropine; Calcium; Calcium Channel Blockers; Child; Child, Preschool; Diltiazem; Dopamine; Drug Overdose; Evaluation Studies as Topic; Female; Heart Block; Humans; Hypotension; Infant; Male; Middle Aged; Nifedipine; Prospective Studies; Verapamil | 1993 |
Radioprotective effects of calcium antagonists used alone or with other types of radioprotectors.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Diltiazem; Dimethyl Sulfoxide; Drug Combinations; Female; Flunarizine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Radiation-Protective Agents; Verapamil; Zinc | 1993 |
Dihydropyridine Ca2+ channel antagonists inhibit the salvage pathway for DNA synthesis in human vascular smooth muscle cells.
Topics: Calcium Channel Blockers; Cell Division; Cells, Cultured; Dihydropyridines; Diltiazem; DNA; Epidermal Growth Factor; Felodipine; Gene Expression Regulation; Genes, fos; Humans; Immunoblotting; Mammary Arteries; Muscle, Smooth, Vascular; Nisoldipine; Thymidine; Verapamil | 1993 |
The use of calcium channel blockers in general practice.
Topics: Calcium Channel Blockers; Cardiovascular Diseases; Dihydropyridines; Diltiazem; Family Practice; Female; Humans; Male; Verapamil | 1993 |
Regulation of membrane-mediated chronic muscle degeneration in dystrophic hamsters by calcium-channel blockers: diltiazem, nifedipine and verapamil.
Topics: Animals; Body Weight; Calcium; Calcium Channel Blockers; Cardiomegaly; Creatine Kinase; Cricetinae; Diltiazem; Fructose-Bisphosphate Aldolase; Hypertrophy; L-Lactate Dehydrogenase; Magnesium; Male; Membranes; Muscles; Muscular Dystrophy, Animal; Nifedipine; Organ Size; Verapamil | 1993 |
Analgesic effects of intracerebroventricular administration of calcium channel blockers in mice.
Topics: Analgesics; Animals; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Injections, Intraventricular; Mice; Naloxone; Pain Measurement; Pain Threshold; Piperazines; Verapamil | 1993 |
Effects of calcium antagonists on K(+)-induced contraction in isolated aorta from diabetic and age-matched control rats.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diltiazem; In Vitro Techniques; Male; Nifedipine; Potassium; Rats; Rats, Wistar; Vasoconstriction; Verapamil | 1993 |
Influence of calmodulin antagonists and calcium channel blockers on triiodothyronine uptake by rat hepatoma and myoblast cell lines.
Topics: Analysis of Variance; Animals; Cadmium; Calcium; Calcium Channel Blockers; Calmodulin; Cell Line; Diltiazem; Imidazoles; Iodine Radioisotopes; Liver Neoplasms, Experimental; Magnesium; Muscles; Nifedipine; Protein Kinase C; Rats; Sulfonamides; Tetradecanoylphorbol Acetate; Trifluoperazine; Triiodothyronine; Tumor Cells, Cultured; Verapamil | 1993 |
ACE-inhibitors, calcium antagonists and low systemic vascular resistance following cardiopulmonary bypass. A case-control study.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Captopril; Cardiopulmonary Bypass; Case-Control Studies; Coronary Artery Bypass; Critical Care; Diltiazem; Dopamine; Enalapril; Female; Heart Valves; Humans; Length of Stay; Male; Middle Aged; Nifedipine; Norepinephrine; Retrospective Studies; Single-Blind Method; Syndrome; Vascular Resistance; Verapamil | 1993 |
Calcium channel blockers in the management of low-tension and open-angle glaucoma.
Topics: Administration, Oral; Aged; Aged, 80 and over; Calcium Channel Blockers; Diltiazem; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Nifedipine; Verapamil; Vision Disorders; Visual Fields | 1993 |
Pharmacological relaxation of the saphenous vein during harvesting for coronary artery bypass grafting.
Topics: Coronary Artery Bypass; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nitroglycerin; Papaverine; Phenylephrine; Potassium; Pressure; Prostaglandin Endoperoxides, Synthetic; Saphenous Vein; Stress, Mechanical; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1993 |
Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Diltiazem; Ductus Arteriosus; Glyburide; In Vitro Techniques; Nickel; Norepinephrine; Oxygen; Potassium; Pyrroles; Rabbits; Vasoconstriction; Verapamil | 1993 |
Low density lipoprotein subfractions and [Ca2+]i in vascular smooth muscle cells.
Topics: Adult; Calcium; Diltiazem; Humans; Lipoproteins, LDL; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Oxidation-Reduction; Verapamil | 1993 |
Characterization of calcium channel blocker induced smooth muscle relaxation using a model of isolated corpus cavernosum.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Penis; Rabbits; Verapamil | 1993 |
On the enzyme-inducing action of calcium antagonists.
Topics: 5-Aminolevulinate Synthetase; Animals; Calcium Channel Blockers; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Induction; Male; Microsomes, Liver; Nifedipine; Rats; Rats, Wistar; Verapamil | 1993 |
Development and validation of a bioanalytical method for the quantification of diltiazem and desacetyldiltiazem in plasma by capillary zone electrophoresis.
Topics: Calcium Channel Blockers; Diltiazem; Electrophoresis, Capillary; Humans; Reference Standards; Reproducibility of Results; Verapamil | 1995 |
Inhibition by verapamil and diltiazem of agonist-stimulated contractile responses in mammalian ventricular cardiomyocytes.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium; Calcium Channel Blockers; Cells, Cultured; Depression, Chemical; Diltiazem; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Secretin; Vasoactive Intestinal Peptide; Ventricular Function; Verapamil | 1995 |
The effects of calcium channel blockers, verapamil, nifedipine and diltiazem, on metabolic control in diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Body Weight; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diltiazem; Glycated Hemoglobin; Male; Nifedipine; Rats; Rats, Wistar; Reference Values; Verapamil | 1995 |
Failure of calcium antagonistic agents to prevent hepatotoxicity induced by diclofenac.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Chelating Agents; Diclofenac; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Liver; Male; Rats; Rats, Wistar; Verapamil | 1995 |
Failure of calcium channel blockade to reduce platelet-mediated cyclic flow variations in dogs with coronary stenosis and endothelial injury.
Topics: Animals; Aspirin; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Disease Models, Animal; Dogs; Endothelium, Vascular; Female; Heart Block; Infusions, Intravenous; Ketanserin; Male; Nifedipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Vasodilator Agents; Verapamil | 1995 |
Block of P-type Ca2+ channels in freshly dissociated rat cerebellar Purkinje neurons by diltiazem and verapamil.
Topics: Animals; Calcium Channels; Cerebellum; Diltiazem; Dose-Response Relationship, Drug; Purkinje Cells; Rats; Rats, Wistar; Time Factors; Verapamil | 1995 |
Antioxidant and calcium channel blockers counteract endothelial barrier injury induced by acute pancreatitis in rats.
Topics: Acetylcysteine; Acute Disease; Animals; Antioxidants; Calcium; Calcium Channel Blockers; Diltiazem; Endothelium; Free Radicals; Gastrointestinal Motility; Male; Pancreatitis; Permeability; Rats; Rats, Sprague-Dawley; Serum Albumin, Radio-Iodinated; Verapamil | 1995 |
Dihydropyridines, phenylalkylamines and benzothiazepines block N-, P/Q- and R-type calcium currents.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Ganglia, Spinal; Heart; Homovanillic Acid; In Vitro Techniques; Ion Channel Gating; Mice; Motor Neurons; Myocardium; Neurons, Afferent; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Spider Venoms; Verapamil | 1995 |
Alcohol inhibits the depolarization-induced stimulation of oxidative phosphorylation in synaptosomes.
Topics: Adenosine Triphosphate; Animals; Cadmium; Calcium; Calcium Channel Blockers; Cell Respiration; Coloring Agents; Diltiazem; Ethanol; Glucose; Ionomycin; Ionophores; Male; Membrane Potentials; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Potassium Chloride; Rats; Rats, Sprague-Dawley; Ruthenium Red; Signal Transduction; Synaptosomes; Verapamil; Veratridine | 1996 |
Ca2+ channel blockers modulate metabolism of collagens within the extracellular matrix.
Topics: Amlodipine; Becaplermin; Calcium Channel Blockers; Cells, Cultured; Collagen; Collagenases; Dihydropyridines; Diltiazem; Enzyme Activation; Extracellular Matrix; Felodipine; Fibroblasts; Humans; Kinetics; Lung; Metalloendopeptidases; Muscle, Smooth, Vascular; Nitrobenzenes; Piperazines; Platelet-Derived Growth Factor; Procollagen; Proline; Proto-Oncogene Proteins c-sis; Transcription, Genetic; Verapamil | 1996 |
Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Death, Sudden, Cardiac; Diltiazem; Disease Models, Animal; Dogs; Electrocardiography; Female; Heart Rate; Hypotension; Infusions, Intravenous; Injections, Intraperitoneal; Male; Nifedipine; Phosphodiesterase Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Respiration; Theophylline; Verapamil | 1996 |
Comparative effect of ursodeoxycholic acid and calcium antagonists on the binding, uptake and degradation of LDL in isolated hamster hepatocytes.
Topics: Animals; Calcium Channel Blockers; Cricetinae; Diltiazem; Iodine Radioisotopes; Lipoproteins, LDL; Liver; Male; Mesocricetus; Methylation; Nifedipine; Ursodeoxycholic Acid; Verapamil | 1996 |
The effects of mibefradil, a novel calcium channel antagonist on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation.
Topics: Animals; Arrhythmias, Cardiac; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Heart Ventricles; Mibefradil; Myocardial Ischemia; Tetrahydronaphthalenes; Verapamil | 1996 |
Evidence for a role of inhibition of sympathetic neurotransmission in the cardiovascular effects of intravenously administered verapamil.
Topics: Animals; Blood Pressure; Cats; Diltiazem; Epinephrine; Female; Heart; Heart Rate; Injections, Intravenous; Male; Nifedipine; Synaptic Transmission; Tachycardia; Verapamil | 1995 |
Calcium channel blockers induce thymic apoptosis in vivo in rats.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Chlorpromazine; Diltiazem; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Hydrocortisone; Hypotension; Image Processing, Computer-Assisted; Injections, Intraperitoneal; Male; Microscopy, Electron; Nicardipine; Nifedipine; Nitroprusside; Organ Size; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; T-Lymphocytes; Thymus Gland; Verapamil | 1996 |
Effect of calcium antagonists on regional cerebral blood flow in transplanted rat brain tumors.
Topics: Analysis of Variance; Animals; Brain; Brain Neoplasms; Calcium Channel Blockers; Cerebrovascular Circulation; Diltiazem; Flunarizine; Glioma; Male; Neoplasm Transplantation; Nifedipine; Nimodipine; Rats; Rats, Wistar; Verapamil | 1996 |
Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Wistar; Verapamil | 1996 |
Porcine gastroepiploic artery as an in vitro experimental model to study vasodilators in microsurgery.
Topics: Animals; Arteries; Culture Techniques; Diltiazem; Microsurgery; Nicardipine; Spasm; Swine; Vasodilator Agents; Verapamil | 1996 |
Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazem.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Electrocardiography; Female; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Serotonin Antagonists; Verapamil | 1996 |
Revisiting calcium channel blockers--from basic facts to clinical practice.
Topics: Aged; Calcium Channel Blockers; Cardiovascular Diseases; Diltiazem; Humans; Hypertension; Nifedipine; Verapamil | 1996 |
Effect of nifedipine, verapamil, diltiazem and trifluoperazine on acetaminophen toxicity in mice.
Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Calcium Channel Blockers; Calmodulin; Cytochrome P-450 Enzyme System; Diltiazem; Glutathione; Lipid Peroxidation; Male; Mice; Microsomes, Liver; Nifedipine; Survival Rate; Trifluoperazine; Verapamil | 1995 |
New treatment of atrial fibrillation.
Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Calcium Channel Blockers; Digoxin; Diltiazem; Drug Therapy, Combination; Emergency Medicine; Heart Failure; Humans; Propanolamines; Verapamil | 1996 |
Effects of calcium antagonist drugs on acetylcholine and high K responses of a molluscan muscle Neptunea antiqua.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Mollusca; Muscle Contraction; Muscles; Nifedipine; Potassium; Verapamil | 1995 |
Characterization of calcium accumulation in the brain of rats administered orally calcium: the significance of energy-dependent mechanism.
Topics: Animals; Biological Transport; Brain; Calcitonin; Calcium; Calcium Channel Blockers; Diltiazem; Energy Metabolism; Fasting; Glucose; Male; Parathyroid Glands; Parathyroid Hormone; Rats; Rats, Wistar; Thyroidectomy; Verapamil | 1996 |
Inhibited neutrophil functions in patients treated with nifedipine but not with verapamil or diltiazem.
Topics: Adult; Calcium; Calcium Channel Blockers; Chemotaxis, Leukocyte; Diltiazem; Humans; Hypertension; Neutrophils; Nifedipine; Phagocytosis; Superoxides; Verapamil | 1996 |
A non-invasive vibrating calcium-selective electrode measures acetylcholine-induced calcium flux across the sarcolemma of a smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Cobalt; Diltiazem; Ion Transport; Lanthanum; Lithium; Microelectrodes; Muscle Contraction; Muscle, Smooth; Sarcolemma; Sea Cucumbers; Verapamil | 1996 |
Effects of verapamil and diltiazem on the ventricular rate during simulated atrial flutter in isolated guinea pig hearts.
Topics: Animals; Atrial Flutter; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Electrocardiography; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle, Smooth; Ventricular Function; Verapamil | 1996 |
How to measure AV nodal refractoriness in the presence of verapamil, amiodarone, digoxin, and diltiazem.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Cardiac Pacing, Artificial; Digoxin; Diltiazem; Electrocardiography; Female; Fourier Analysis; Guinea Pigs; Heart Rate; Male; Signal Processing, Computer-Assisted; Verapamil | 1996 |
Relative selectivity for negative chronotropic and inotropic effects of a novel dihydropyridine derivative CD-832.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Guinea Pigs; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nifedipine; Osmolar Concentration; Papillary Muscles; Patch-Clamp Techniques; Verapamil | 1996 |
Diltiazem and verapamil prevent vitamin D3-induced myocardial calcium overload in rat papillary muscle: assessment with PVC ETH-123 calcium-selective microelectrodes.
Topics: Animals; Calcium; Calcium Channel Blockers; Cholecalciferol; Diltiazem; Microelectrodes; Papillary Muscles; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Effect of multiple administration of calcium antagonists on lipid peroxidation in rat liver microsomes.
Topics: Animals; Antioxidants; Ascorbic Acid; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Lipid Peroxidation; Male; Microsomes, Liver; Nifedipine; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Verapamil | 1996 |
Effect of verapamil and diltiazem on the rCBF and the rCBF autoregulation in cortex and thalamus of cats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cats; Cerebral Cortex; Cerebrovascular Circulation; Diltiazem; Female; Homeostasis; Male; Thalamus; Verapamil | 1995 |
Differentiated effects of vasodilators on myogenic reactivity during partial inhibition of myogenic tone in pressurized skeletal muscle small arteries of the rat.
Topics: Acetylcholine; Animals; Arteries; Calcium Channel Blockers; Diltiazem; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth, Vascular; Pinacidil; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1996 |
Temporal variation in the interaction between calcium channel blockers and morphine-induced analgesia.
Topics: Analgesia; Animals; Calcium Channel Blockers; Circadian Rhythm; Diltiazem; Drug Synergism; Male; Mice; Mice, Inbred BALB C; Morphine; Nicardipine; Pain; Verapamil | 1996 |
Effects of calcium channel blockers on spontaneous electrical activity of freshly isolated three-day-old embryonic chick ventricle.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Chick Embryo; Diltiazem; Dose-Response Relationship, Drug; Fendiline; Heart Ventricles; In Vitro Techniques; Isoproterenol; Nifedipine; Regression Analysis; Tetrodotoxin; Ventricular Function; Verapamil | 1996 |
Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A.
Topics: Adult; Antigenic Variation; Calcium Channel Blockers; Chi-Square Distribution; Cyclosporine; Diltiazem; Disease Susceptibility; Drug Combinations; Female; Gingival Overgrowth; HLA Antigens; HLA-DR1 Antigen; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Nifedipine; Pharmacogenetics; Statistics, Nonparametric; Verapamil | 1996 |
Effects of verapamil on acute murine Chagas' disease.
Topics: Acute Disease; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Cells, Cultured; Chagas Disease; Diltiazem; Endothelium, Vascular; GTP-Binding Proteins; Humans; Male; Mice; Myocardium; Prazosin; Propranolol; Trypanosoma cruzi; Umbilical Veins; Verapamil | 1996 |
Effects of calcium channel blockers on steroidogenesis stimulated by ACTH and cAMP in isolated rat adrenal cells.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Calcium Channel Blockers; Cells, Cultured; Corticosterone; Cyclic AMP; Diltiazem; Male; Nifedipine; Rats; Rats, Wistar; Verapamil | 1996 |
Effects of anandamide and arachidonic acid on specific binding of (+) -PN200-110, diltiazem and (-) -desmethoxyverapamil to L-type Ca2+ channel.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endocannabinoids; Isradipine; Male; Polyunsaturated Alkamides; Rabbits; Verapamil | 1996 |
Characterization of apamin-sensitive Ca(2+)-activated potassium channels in human leukaemic T lymphocytes.
Topics: Apamin; Barium; Calcium; Calcium Channel Blockers; Cations, Divalent; Cations, Monovalent; Cell Membrane Permeability; Clotrimazole; Diltiazem; Humans; Ionomycin; Jurkat Cells; Kinetics; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Scorpion Venoms; Strontium; Verapamil | 1996 |
Effect of calcium channel blockers on the action of various antitumour agents in the yeast Saccharomyces cerevisiae.
Topics: Antineoplastic Agents; Calcium Channel Blockers; Cell Survival; Diltiazem; Doxorubicin; Fluorouracil; Saccharomyces cerevisiae; Verapamil | 1996 |
The potential synergistic effect of calcium channel blockers and alpha-tocopherol on gastric mucosal injury induced by ischaemia-reperfusion.
Topics: Administration, Oral; Animals; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gastric Mucosa; Injections, Intraperitoneal; Male; Nifedipine; Rats; Rats, Wistar; Reperfusion Injury; Verapamil; Vitamin E; Wound Healing | 1996 |
Purinergic stimulation of rabbit ciliated airway epithelia: control by multiple calcium sources.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Cilia; Diltiazem; Ionomycin; Kinetics; Rabbits; Receptors, Purinergic; Thapsigargin; Trachea; Verapamil | 1996 |
Effects of calcium antagonists on binding of local anesthetics to plasma proteins and erythrocytes in mice.
Topics: Anesthetics, Local; Animals; Blood Proteins; Bupivacaine; Calcium Channel Blockers; Diltiazem; Erythrocytes; In Vitro Techniques; Lidocaine; Male; Mice; Nicardipine; Protein Binding; Verapamil | 1996 |
Suppression of oxidant production by diltiazem, nifedipine and verapamil in human neutrophils.
Topics: Calcium Channel Blockers; Cells, Cultured; Depression, Chemical; Diltiazem; Humans; Neutrophils; Nifedipine; Oxidants; Oxygen; Tetradecanoylphorbol Acetate; Verapamil; Zymosan | 1996 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Tetrandrine inhibits electrically induced [Ca2+]i transient in the isolated single rat cardiomyocyte.
Topics: Alkaloids; Animals; Benzylisoquinolines; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; Electric Stimulation; Heart; In Vitro Techniques; Potassium Chloride; Rats; Rats, Sprague-Dawley; Ryanodine; Sodium; Thapsigargin; Verapamil | 1997 |
Involvement of calcium in the cardiac depressant actions of a garlic dialysate.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Dialysis; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Garlic; Heart Atria; Male; Myocardial Contraction; Nifedipine; Plant Extracts; Plants, Medicinal; Rats; Verapamil | 1997 |
Quantification of rate-dependent effects of verapamil, diltiazem, and digoxin on atrioventricular conduction.
Topics: Adaptation, Physiological; Animals; Atrioventricular Node; Calcium Channel Blockers; Digoxin; Diltiazem; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Sinoatrial Node; Time Factors; Verapamil | 1996 |
Inhibition of PDGF-mediated proliferation of vascular smooth muscle cells by calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Cell Division; Cells, Cultured; Diltiazem; DNA Replication; Growth Inhibitors; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Muscle, Smooth, Vascular; Myristoylated Alanine-Rich C Kinase Substrate; Nifedipine; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Rats; Transcription Factor AP-1; Verapamil | 1997 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female; In Vitro Techniques; Ketanserin; Male; Mianserin; Muscle Contraction; Nifedipine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reproducibility of Results; Ritanserin; Serotonin Antagonists; Verapamil | 1997 |
Human diploid fibroblast cell culture medium contains a factor that increases cytosolic Ca2+ and stimulates prostaglandin synthesis by cultured bovine aortic endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Bradykinin; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Culture Media, Conditioned; Cycloheximide; Cytosol; Diltiazem; Dinoprostone; Diploidy; Endothelium, Vascular; Epoprostenol; Fibroblasts; Humans; Protein Synthesis Inhibitors; Verapamil | 1997 |
Effect of pre-treatment of some calcium channel blockers on catalepsy and stereotypic behaviour in rats.
Topics: Animals; Calcium Channel Blockers; Catalepsy; Central Nervous System Depressants; Central Nervous System Stimulants; Diltiazem; Female; Haloperidol; Male; Methamphetamine; Nifedipine; Rats; Rats, Wistar; Stereotyped Behavior; Verapamil | 1996 |
Influence of opiate tolerance and calcium channel antagonists on the antinociceptive effects of L-arginine and NG-nitro L-arginine.
Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Calcium Channel Blockers; Diltiazem; Drug Tolerance; Enzyme Inhibitors; Male; Mice; Morphine; Nitric Oxide Synthase; Nitroarginine; Pain Measurement; Pentazocine; Verapamil | 1997 |
Effects of extracellular calcium concentrations and calcium antagonists on vitellogenin induction by estradiol-17 beta in primary hepatocyte culture in the rainbow trout Oncorhynchus mykiss.
Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Electrophoresis, Polyacrylamide Gel; Estradiol; Human Growth Hormone; Kinetics; Lanthanum; Liver; Oncorhynchus mykiss; Prolactin; Verapamil; Vitellogenins | 1997 |
On-line column-switching high-performance liquid chromatography analysis of cardiovascular drugs in serum with automated sample clean-up and zone-cutting technique to perform chiral separation.
Topics: Cardiovascular Agents; Chromatography, High Pressure Liquid; Diltiazem; Lidocaine; Linear Models; Metoprolol; Online Systems; Oxprenolol; Pindolol; Sensitivity and Specificity; Stereoisomerism; Verapamil | 1997 |
High-affinity binding of DTZ323, a novel derivative of diltiazem, to rabbit skeletal muscle L-type Ca++ channels.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Isradipine; Male; Muscle, Skeletal; Rabbits; Verapamil | 1997 |
Calcium entry blockers increase interleukin-10 production in endotoxemia.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Endotoxemia; Interleukin-10; Interleukin-6; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Nitric Oxide; Tumor Necrosis Factor-alpha; Verapamil | 1997 |
Calcium-channel blockers preserve coronary endothelial reactivity after ischemia-reperfusion.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Vessels; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Male; Muscle Relaxation; Myocardial Reperfusion Injury; Nifedipine; Rats; Rats, Sprague-Dawley; Verapamil | 1997 |
Hepatotoxicity of ethanol: protective effect of calcium channel blockers in isolated hepatocytes.
Topics: Animals; Calcium Channel Blockers; Cell Death; Cells, Cultured; Diltiazem; Drug Antagonism; Ethanol; Liver; Male; Nifedipine; Rats; Rats, Wistar; Verapamil | 1997 |
Inhibition of recombinant Ca2+ channels by benzothiazepines and phenylalkylamines: class-specific pharmacology and underlying molecular determinants.
Topics: Calcium Channel Blockers; Calcium Channels; Cell Line; Diltiazem; Dose-Response Relationship, Drug; Humans; Ion Channel Gating; Recombinant Proteins; Verapamil | 1997 |
Carbamazepine and L-type calcium channel inhibitors: a binding assay study.
Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Calcium Channel Blockers; Carbamazepine; Diltiazem; In Vitro Techniques; Isradipine; Lithium; Male; Phenethylamines; Rats; Rats, Wistar; Verapamil | 1996 |
Effects of a novel, potent benzothiazepine Ca2+ channel antagonist, DTZ323, on guinea-pig ventricular myocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Sodium Channels; Verapamil | 1997 |
A quick guide to converting rapid rhythms. When seconds count, use this chart to guide treatment choices.
Topics: Adenosine; Anti-Arrhythmia Agents; Calcium Channel Blockers; Diltiazem; Humans; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil; Wolff-Parkinson-White Syndrome | 1997 |
Effect of 4-aminopyridine and 3,4-diaminopyridine on guinea-pig isolated ileum.
Topics: 4-Aminopyridine; Acetylcholine; Amifampridine; Animals; Atropine; Calcium Channel Blockers; Diazoxide; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; Flunarizine; Guinea Pigs; Ileum; In Vitro Techniques; Lanthanum; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Parasympathetic Nervous System; Parasympatholytics; Potassium Channels; Vasodilator Agents; Verapamil | 1997 |
A challenge to the concept that the use of calcium channel blockers causes reversible male infertility.
Topics: Calcium Channel Blockers; Diltiazem; Embryo Transfer; Female; Fertilization in Vitro; Humans; Infertility, Male; Male; Oligospermia; Pregnancy; Retrospective Studies; Verapamil | 1997 |
Active calcium ion transport Xenopus laevis skin.
Topics: Animals; Biological Transport, Active; Calcium; Calcium Channel Blockers; Calcium Channels; Cobalt; Diltiazem; Dose-Response Relationship, Drug; Ion Transport; Lanthanum; Membrane Potentials; Nickel; Nifedipine; Skin; Verapamil; Xenopus laevis | 1997 |
The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholinesterase; Amyloid beta-Peptides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Carcinoma, Embryonal; Diltiazem; Gene Expression Regulation, Enzymologic; Kinetics; Marine Toxins; Nifedipine; Oxocins; Peptide Fragments; Tumor Cells, Cultured; Verapamil | 1997 |
Verapamil or diltiazem for acute rate control.
Topics: Atrial Fibrillation; Atrial Flutter; Cost-Benefit Analysis; Diltiazem; Heart Rate; Humans; Treatment Outcome; Verapamil | 1997 |
Evidence for antiaggressive property of some calcium channel blockers.
Topics: Aggression; Amphetamine; Animals; Calcium Channel Blockers; Central Nervous System Stimulants; Depression, Chemical; Diltiazem; Electroshock; Male; Mice; Nifedipine; Parasympathomimetics; Physostigmine; Verapamil | 1997 |
Dopamine potentiation of calcium ionophore, A-23187-induced platelet aggregation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaloids; Androstadienes; Aspirin; Benzophenanthridines; Calcimycin; Calcium; Chlorpromazine; Diltiazem; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; GTP-Binding Proteins; Haloperidol; Homovanillic Acid; Humans; Indomethacin; Ion Transport; Ionophores; Phenanthridines; Phentolamine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Dopamine; Serotonin; Signal Transduction; Verapamil; Wortmannin | 1997 |
Spectral analysis of intercycle heart fluctuations in Xenopus laevis, conscious or spinalized, treated with calcium channel blockers. Part I.
Topics: Animals; Calcium Channel Blockers; Decerebrate State; Diltiazem; Dose-Response Relationship, Drug; Electrocardiography; Heart; Heart Rate; In Vitro Techniques; Nifedipine; Verapamil; Xenopus laevis | 1997 |
Effect of calcium antagonists on plasma norepinephrine levels, heart rate, and blood pressure.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Routes; Follow-Up Studies; Heart Rate; Humans; Hypertension; MEDLINE; Middle Aged; Norepinephrine; Retrospective Studies; Time Factors; Verapamil | 1997 |
[Stable angina pectoris: what is the role of calcium antagonists?].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Felodipine; Humans; Metoprolol; Multicenter Studies as Topic; Nifedipine; Randomized Controlled Trials as Topic; Verapamil | 1997 |
Outcome with calcium channel antagonists after myocardial infarction: a community-based study.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Calcium Channel Blockers; Cohort Studies; Diltiazem; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nifedipine; Verapamil | 1998 |
Comparison of diltiazem and verapamil on rat microvascular permeability.
Topics: Animals; Capillary Leak Syndrome; Capillary Permeability; Diltiazem; Edema; Evans Blue; Injections, Intravenous; Male; Rats; Rats, Wistar; Serum Albumin; Skin; Verapamil | 1997 |
Isradipine and lacidipine: effects in vivo and in vitro on Trypanosoma cruzi epimastigotes.
Topics: Animals; Calcium Channel Blockers; Cattle; Dihydropyridines; Diltiazem; Isradipine; Oxygen Consumption; Trypanocidal Agents; Trypanosoma cruzi; Verapamil | 1998 |
Calcium channels mediate angiotensin II-induced drinking behaviour and c-fos expression in the brain.
Topics: Angiotensin II; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Cerebral Ventricles; Corticosterone; Diltiazem; Drinking Behavior; Infusions, Parenteral; Male; Nerve Tissue Proteins; Nifedipine; Proto-Oncogene Proteins c-fos; Rats; Verapamil | 1997 |
Calcium channel blocking agents and risk of cancer in patients with coronary heart disease. Benzafibrate Infarction Prevention (BIP) Study Research Group.
Topics: Aged; Calcium Channel Blockers; Cause of Death; Confidence Intervals; Coronary Disease; Diltiazem; Female; Humans; Male; Middle Aged; Neoplasms; Nifedipine; Odds Ratio; Risk Factors; Verapamil | 1998 |
Catalepsy induced by calcium channel blockers in mice.
Topics: Amlodipine; Animals; Binding, Competitive; Calcium Channel Blockers; Catalepsy; Dihydropyridines; Diltiazem; Disease Models, Animal; Flunarizine; Male; Mice; Muscarinic Antagonists; Nitrobenzenes; Piperazines; Predictive Value of Tests; Receptors, Cholinergic; Receptors, Dopamine D1; Receptors, Dopamine D2; Scopolamine; Time Factors; Verapamil | 1998 |
Electrophysiologic assessment of calcium channel blockers in transplanted hearts: an experimental study.
Topics: Animals; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Heart; Heart Transplantation; Hemodynamics; Nifedipine; Sinoatrial Node; Transplantation, Heterotopic; Ventricular Function; Verapamil | 1998 |
Effects of antihypertensive drugs on cholesterol metabolism of human mononuclear leukocytes and hepatoma cells.
Topics: Antihypertensive Agents; Carcinoma, Hepatocellular; Cholesterol; Diltiazem; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Metoprolol; Nifedipine; Propranolol; Tumor Cells, Cultured; Verapamil | 1998 |
Effect of diltiazem and verapamil on endothelin release by cultured human coronary smooth-muscle cells and endothelial cells.
Topics: Aged; Calcium Channel Blockers; Cells, Cultured; Coronary Disease; Coronary Vessels; Depression, Chemical; Diltiazem; Endothelins; Endothelium, Vascular; Humans; Muscle, Smooth, Vascular; Verapamil | 1998 |
[Anticholinesterase effect of calcium channel blockers: diltiazem, verapamil, and nifedipine].
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Calcium Channel Blockers; Cholinesterase Inhibitors; Diltiazem; Horses; Humans; In Vitro Techniques; Kinetics; Nifedipine; Verapamil | 1998 |
Verapamil inhibits proliferation, migration and protein kinase C activity in human retinal pigment epithelial cells.
Topics: Calcium Channel Blockers; Cell Division; Cell Movement; Cells, Cultured; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Humans; Nifedipine; Pigment Epithelium of Eye; Protein Kinase C; Verapamil | 1998 |
Interaction between calcium channel blockers and sweetening agents on morphine-induced analgesia in mice by formalin test.
Topics: Analgesics; Animals; Aspartame; Calcium Channel Blockers; Diltiazem; Drug Interactions; Male; Mice; Morphine; Nifedipine; Pain Measurement; Saccharin; Sucrose; Sweetening Agents; Verapamil | 1998 |
Antinociceptive effects of intrathecal L-type calcium channel blockers on visceral and somatic stimuli in the rat.
Topics: Analgesics; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Male; Pain Threshold; Rats; Rats, Sprague-Dawley; Reaction Time; Tail; Verapamil; Viscera | 1998 |
The effects of verapamil and diltiazem pretreatment on potassium release in dogs after the administration of succinylcholine.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Neuromuscular Blocking Agents; Potassium; Succinylcholine; Verapamil | 1998 |
Right vagal nerve stimulation during minimally invasive direct coronary artery bypass grafting in dogs. A preliminary study.
Topics: Animals; Cardiovascular Agents; Coronary Artery Bypass; Diltiazem; Dogs; Electric Stimulation; Electrocardiography; Heart Rate; Intraoperative Period; Minimally Invasive Surgical Procedures; Thoracic Nerves; Vagus Nerve; Verapamil | 1998 |
Dual effects of nimesulide, a COX-2 inhibitor, in human platelets.
Topics: Blood Platelets; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Epinephrine; Humans; Nitric Oxide Donors; Penicillamine; Platelet Aggregation; Platelet Aggregation Inhibitors; Sulfonamides; Thromboxane A2; Verapamil | 1998 |
[The objective assessment of treatment efficacy in microfocal myocardial infarct using paired stress tests].
Topics: Acebutolol; Adrenergic beta-Antagonists; Calcium Channel Blockers; Cardiac Pacing, Artificial; Diltiazem; Drug Evaluation; Electrocardiography; Exercise Test; Humans; Myocardial Infarction; Propranolol; Verapamil | 1998 |
Protein kinase C-mediated up-regulation of Na+/Ca2+-exchanger in rat hepatocytes determined by a new Na+/Ca2+-exchanger inhibitor, KB-R7943.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Extracellular Space; Liver; Male; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger; Thiourea; Up-Regulation; Verapamil | 1998 |
Effects of Ca2+ channel blockers on apomorphine, bromocriptine and morphine-induced locomotor activity in mice.
Topics: Amlodipine; Animals; Apomorphine; Benzazepines; Bromocriptine; Calcium Channel Blockers; Diltiazem; Dopamine Antagonists; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Mice; Morphine; Motor Activity; Nicardipine; Time Factors; Verapamil | 1999 |
Absence of a dose-response of cyclosporine levels to clinically used doses of diltiazem and verapamil.
Topics: Administration, Oral; Calcium Channel Blockers; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Isradipine; Medical Records; Nifedipine; Radioimmunoassay; Retrospective Studies; Verapamil | 1999 |
Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine.
Topics: Amlodipine; Antihypertensive Agents; Antioxidants; Calcium; Calorimetry, Differential Scanning; Diltiazem; Dimyristoylphosphatidylcholine; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Inhibitory Concentration 50; Lipid Peroxidation; Phosphatidylcholines; Verapamil | 1999 |
Isoniazid accumulation in Mycobacterium smegmatis is modulated by proton motive force-driven and ATP-dependent extrusion systems.
Topics: Adenosine Triphosphate; Antitubercular Agents; Biological Transport, Active; Calcium Channel Blockers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Diltiazem; Drug Resistance, Microbial; Hydrogen-Ion Concentration; Ionophores; Isoniazid; Mycobacterium smegmatis; Nifedipine; Nigericin; Proton-Motive Force; Reserpine; Uncoupling Agents; Valinomycin; Vanadates; Verapamil | 1999 |
Nifedipine, verapamil and diltiazem block shock-wave-induced rises in cytosolic calcium in MDCK cells.
Topics: Adenosine Triphosphate; Animals; Aspartate Aminotransferases; Bradykinin; Calcium; Calcium Channel Blockers; Cell Line; Cytosol; Diltiazem; Dogs; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Kidney Diseases; Kidney Tubules; L-Lactate Dehydrogenase; Lithotripsy; Nifedipine; Thapsigargin; Verapamil | 1998 |
Gingival hyperplasia due to calcium antagonists.
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Gingival Hyperplasia; Humans; Nifedipine; Verapamil | 1998 |
Requirement of Ca2+ for aflatoxin production: inhibitory effect of Ca2+ channel blockers on aflatoxin production by Aspergillus parasiticus NRRL 2999.
Topics: Acetates; Aflatoxin B1; Aflatoxins; Aspergillus; Biological Transport; Calcium; Calcium Channel Blockers; Diltiazem; Glucose; Verapamil | 1999 |
Temporal differences in actions of calcium channel blockers on K+ accumulation, cardiac function, and high-energy phosphate levels in ischemic guinea pig hearts.
Topics: Acidosis; Adenosine Triphosphate; Animals; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Extracellular Space; Guinea Pigs; Heart; Heart Rate; Hydrogen-Ion Concentration; In Vitro Techniques; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Nifedipine; Phosphocreatine; Potassium; Time Factors; Verapamil | 1999 |
Presynaptic calcium-channel currents in normal and csp mutant Drosophila peptidergic terminals.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Drosophila; Exocytosis; HSP40 Heat-Shock Proteins; Membrane Potentials; Membrane Proteins; Muscles; Neurons; Nifedipine; Patch-Clamp Techniques; Presynaptic Terminals; Verapamil | 1999 |
Class differences in the effects of calcium channel blockers in the rat remnant kidney model.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Drinking; Felodipine; Glomerulosclerosis, Focal Segmental; Homeostasis; Hypertension, Renal; Hypertrophy; Kidney Glomerulus; Male; Nephrectomy; Proteinuria; Radio Waves; Rats; Rats, Sprague-Dawley; Telemetry; Verapamil | 1999 |
Effects of long-acting versus short-acting calcium channel blockers among older survivors of acute myocardial infarction.
Topics: Aged; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Humans; Male; Myocardial Infarction; Nicardipine; Nifedipine; Proportional Hazards Models; Retrospective Studies; Risk; Survival Analysis; Survivors; Verapamil | 1999 |
Mechanism of block and identification of the verapamil binding domain to HERG potassium channels.
Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cation Transport Proteins; Cell Line; Diltiazem; DNA-Binding Proteins; Electric Conductivity; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydrogen-Ion Concentration; Intracellular Membranes; Mutation; Nifedipine; Phenethylamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Sulfonamides; Trans-Activators; Transcriptional Regulator ERG; Verapamil | 1999 |
LDL receptor gene expression in human mesangial cells under the influence of calcium channel blockers.
Topics: Blotting, Northern; Calcium Channel Blockers; Cell Division; Cells, Cultured; Diltiazem; Gene Expression; Glomerular Mesangium; Humans; Lipoproteins, LDL; Nifedipine; Receptors, LDL; RNA, Messenger; Signal Transduction; Transcription, Genetic; Verapamil | 1999 |
The effects of verapamil and diltiazem on N-, P- and Q-type calcium channels mediating dopamine release in rat striatum.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Calcium Channels, N-Type; Calcium Channels, T-Type; Diltiazem; Dopamine; In Vitro Techniques; Neostriatum; Potassium; Rats; Tetrodotoxin; Verapamil; Veratridine | 1999 |
Effects of calcium channel antagonists on LPS-induced hepatic iNOS expression.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Calcium-Binding Proteins; Cell Nucleus; Cells, Cultured; Cytoplasm; Diltiazem; DNA-Binding Proteins; I-kappa B Proteins; Kinetics; Kupffer Cells; Lipopolysaccharides; Liver; Male; Membrane Glycoproteins; Nerve Tissue Proteins; Nifedipine; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; RNA, Messenger; Synaptotagmin I; Synaptotagmins; Verapamil | 1999 |
In vitro effects of calcium channel blockers and beta-adrenergic blocking agents on microsomal lipid perocidation and cytochrome p-450 content.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Calcium Channel Blockers; Cytochrome P-450 Enzyme System; Diltiazem; In Vitro Techniques; Lipid Peroxidation; Male; Microsomes, Liver; Nifedipine; Propranolol; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Verapamil | 1999 |
[Effects of calcium channel blockers and calmodulin inhibitors on the secretion of endothelin-1 in cultured endothelial cells].
Topics: Alkaloids; Benzylisoquinolines; Calcium Channel Blockers; Calmodulin; Cells, Cultured; Chlorpromazine; Diltiazem; Endothelin-1; Endothelium, Vascular; Humans; Nitroglycerin; Umbilical Veins; Verapamil | 1997 |
Differential blockade of rat alpha3beta4 and alpha7 neuronal nicotinic receptors by omega-conotoxin MVIIC, omega-conotoxin GVIA and diltiazem.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Female; Kinetics; Membrane Potentials; Neurons; Nicotinic Agonists; omega-Conotoxin GVIA; omega-Conotoxins; Oocytes; Peptides; Rats; Receptors, Nicotinic; Time Factors; Verapamil; Xenopus laevis | 1999 |
Characterization of the pharmacological-sensitivity profile of neoglycoprotein-induced acrosome reaction in mouse spermatozoa.
Topics: Acrosome Reaction; alpha-Mannosidase; Animals; Calcimycin; Calcium Channel Blockers; Cell Membrane; Diltiazem; Glucosyltransferases; Glycoproteins; Ionophores; Male; Mannosidases; Mice; Mice, Inbred C57BL; Sperm Capacitation; Spermatozoa; Verapamil | 1999 |
[The demonstration of steady-state Ca2+ influx into the cells of the salivary glands in Chironomus plumosus L. larvae and its role in basal secretion].
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Chironomidae; Diltiazem; In Vitro Techniques; Larva; Nifedipine; Salivary Glands; Salivation; Verapamil | 1999 |
Effect of polymer/basic drug interactions on the two-stage diffusion-controlled release from a poly(L-lactic acid) matrix.
Topics: Biocompatible Materials; Chlorpheniramine; Crystallization; Delayed-Action Preparations; Diffusion; Diltiazem; Drug Interactions; Kinetics; Lactic Acid; Papaverine; Polyesters; Polymers; Verapamil; Water; X-Ray Diffraction | 1999 |
Antioxidant properties of calcium antagonists related to membrane biophysical interactions.
Topics: Amlodipine; Animals; Antioxidants; Calcium Channel Blockers; Calorimetry, Differential Scanning; Diltiazem; Dose-Response Relationship, Drug; Intracellular Membranes; Lipid Peroxidation; Male; Microsomes, Liver; Radioligand Assay; Rats; Rats, Sprague-Dawley; Verapamil; X-Ray Diffraction | 1999 |
Early treatment with verapamil or diltiazem in patients with acute myocardial infarction: safety and possible beneficial effects.
Topics: Acute Disease; Calcium Channel Blockers; Diltiazem; Female; Humans; Male; Middle Aged; Myocardial Infarction; Time Factors; Treatment Outcome; Verapamil | 1999 |
Calcium channel blockers and mortality in elderly patients with myocardial infarction.
Topics: Aged; Aged, 80 and over; Amlodipine; Bepridil; Calcium Channel Blockers; Diltiazem; Female; Humans; Logistic Models; Male; Myocardial Infarction; Nifedipine; Retrospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; United States; Verapamil | 1999 |
Comparative study on calcium channel antagonists in the human radial artery: clinical implications.
Topics: Analysis of Variance; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Nicardipine; Nifedipine; Radial Artery; Vasodilator Agents; Verapamil | 2000 |
L-type Ca2+ channels are not involved in coronary endothelial Ca2+ influx mechanism responsible for endothelium-dependent relaxation.
Topics: Analysis of Variance; Animals; Bradykinin; Calcium; Calcium Channel Blockers; Calcium Channels; Coronary Vessels; Diltiazem; Endothelium, Vascular; Female; Male; Nicardipine; Nitric Oxide; Substance P; Swine; Verapamil | 1999 |
Effects of the T-type Ca(2+) channel blocker mibefradil on repolarization of guinea pig, rabbit, dog, monkey, and human cardiac tissue.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; Guinea Pigs; Heart; Heart Atria; Humans; In Vitro Techniques; Male; Mibefradil; Rabbits; Saimiri; Sotalol; Telemetry; Time Factors; Verapamil | 2000 |
Nifedipine and diltiazem but not verapamil up-regulate endothelial nitric-oxide synthase expression.
Topics: Calcium Channel Blockers; Cell Division; Cells, Cultured; Coronary Vessels; Diltiazem; Endothelium, Vascular; Humans; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Up-Regulation; Verapamil | 2000 |
N-Type calcium channels control sympathetic neurotransmission in human heart atrium.
Topics: Adult; Aged; Amlodipine; Calcium Channel Blockers; Calcium Channels, N-Type; Diltiazem; Electric Stimulation; Female; Heart; Heart Atria; Humans; Male; Mibefradil; Middle Aged; Norepinephrine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Sympathetic Nervous System; Synaptic Transmission; Verapamil | 2000 |
Efficacy of the novel calcium antagonist R(+)-semotiadil in limiting the ventricular rate during atrial flutter in isolated guinea pig hearts.
Topics: Animals; Atrial Flutter; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; In Vitro Techniques; Male; Thiazoles; Time Factors; Ventricular Function; Verapamil | 2000 |
Effects of calcium channel blockers on calcium release-activated calcium currents in rat hepatocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Female; Liver; Male; Nifedipine; Patch-Clamp Techniques; Rats; Rats, Wistar; Verapamil | 1999 |
Quantitative prediction of metabolic inhibition of midazolam by erythromycin, diltiazem, and verapamil in rats: implication of concentrative uptake of inhibitors into liver.
Topics: Animals; Blood Proteins; Diltiazem; Drug Interactions; Erythromycin; Hypnotics and Sedatives; Liver; Male; Midazolam; Protein Binding; Rats; Rats, Sprague-Dawley; Verapamil | 2000 |
Rapid increase in immunoreactivity to GFAP in astrocytes in vitro induced by acidic pH is mediated by calcium influx and calpain I.
Topics: Acids; Amino Acid Sequence; Animals; Antibodies; Astrocytes; Calcimycin; Calcium; Calcium Channel Blockers; Calpain; Carrier Proteins; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Diltiazem; Egtazic Acid; Enzyme Activation; Glial Fibrillary Acidic Protein; Glycoproteins; Hydrogen-Ion Concentration; In Vitro Techniques; Ionophores; Microfilament Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Nifedipine; Prosencephalon; Rats; Rats, Inbred F344; Substrate Specificity; Verapamil | 2000 |
Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Diltiazem; Dioxanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Ischemia; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Phenoxybenzamine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Renal Artery; Renal Circulation; Swine; Thapsigargin; Verapamil | 2000 |
Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Chelating Agents; Diltiazem; Dinucleoside Phosphates; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Hypoxia; Imidazoles; In Vitro Techniques; Ion Channel Gating; Lanthanum; Male; Membrane Potentials; Nifedipine; Phosphodiesterase Inhibitors; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Ryanodine; Thapsigargin; Vasoconstriction; Verapamil | 2000 |
Gonadotropin-releasing hormone-stimulated sperm binding to the human zona is mediated by a calcium influx.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Egtazic Acid; Female; Gonadotropin-Releasing Hormone; Humans; Male; Mibefradil; Nifedipine; Pimozide; Sperm-Ovum Interactions; Spermatozoa; Verapamil; Zona Pellucida | 2000 |
Evaluation of calcium channel blockers as potential hepatoprotective agents in oxidative stress injury of perfused hepatocytes.
Topics: Adenosine Triphosphatases; Animals; Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Diltiazem; Hepatocytes; L-Lactate Dehydrogenase; Lipid Peroxides; Liver Diseases; Male; Oxidative Stress; Oxygen Consumption; Perfusion; Rats; Rats, Wistar; tert-Butylhydroperoxide; Verapamil | 2000 |
Ca2+-agonistic effect of a T-type Ca-channel blocker mibefradil (Ro 40-5967).
Topics: Amlodipine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cells, Cultured; Coronary Vessels; Diltiazem; Mibefradil; Muscle, Smooth, Vascular; Swine; Verapamil | 2000 |
The differential effects of calcium channel blockers in the behavioural despair test in mice.
Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Clomipramine; Clonidine; Cyproheptadine; Depression; Desipramine; Diltiazem; Drug Interactions; Female; Male; Mianserin; Mice; Motor Activity; Nifedipine; Tranylcypromine; Verapamil | 2000 |
Amlodipine inhibits thapsigargin-sensitive CA(2+) stores in thrombin-stimulated vascular smooth muscle cells.
Topics: Amlodipine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Transporting ATPases; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Intracellular Fluid; Isradipine; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Rats, Inbred WKY; Sarcoplasmic Reticulum; Signal Transduction; Thapsigargin; Thrombin; Verapamil | 2000 |
Effects of diltiazem on human nicotinic acetylcholine and GABA(A) receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Binding Sites; Binding, Competitive; Bungarotoxins; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Diltiazem; Electrophysiology; GABA-A Receptor Antagonists; Humans; Indicators and Reagents; Iodine Radioisotopes; Receptors, Nicotinic; Verapamil | 2000 |
Nifedipine inhibits activation of transcription factor NF-kappaB.
Topics: Amlodipine; Calcium Channel Blockers; Cell Migration Inhibition; Diltiazem; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Interleukin-1; Lipopolysaccharides; Luciferases; Lung Neoplasms; Lymphocyte Activation; Macrophages; NF-kappa B; Nifedipine; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Verapamil | 2000 |
Ca(2+)-channel blockers and nucleoside triphosphate diphosphohydrolase (NTPDase) influence of diltiazem, nifedipine, and verapamil.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cattle; Diltiazem; In Vitro Techniques; Kinetics; Nifedipine; Pyrophosphatases; Verapamil | 2000 |
Structure-activity relationship of P-glycoprotein substrates and modifiers.
Topics: Adenosine Triphosphatases; Amiodarone; Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Daunorubicin; Diltiazem; Kinetics; Micelles; Progesterone; Propranolol; Structure-Activity Relationship; Verapamil; Vinblastine | 2000 |
Calcium channel blockers verapamil and diltiazem impaired rubratoxin B-caused toxicity in HL60 cells.
Topics: Apoptosis; Calcium Channel Blockers; Calcium Signaling; Cell Survival; Diltiazem; DNA Fragmentation; HL-60 Cells; Humans; Mycotoxins; Verapamil | 2000 |
L-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts.
Topics: Animals; Antioxidants; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Egtazic Acid; Fibroblasts; Myocardium; Rats; Rats, Sprague-Dawley; Ryanodine; Superoxides; Time Factors; Verapamil | 2001 |
[Vasodilators in isolated human radial arteries].
Topics: Aged; Coronary Artery Bypass; Diltiazem; Humans; Male; Middle Aged; Nitroglycerin; Radial Artery; Spasm; Vasodilator Agents; Verapamil | 2000 |
Inhibition by nifedipine of adherence- and activated macrophage-induced death of human gingival fibroblasts.
Topics: Animals; Calcium Channel Blockers; Cell Adhesion; Cell Death; Cell Division; Cell Line; Cells, Cultured; Coculture Techniques; Diltiazem; DNA Fragmentation; Dose-Response Relationship, Drug; Fibroblasts; Gingiva; Humans; Lipopolysaccharides; Macrophages; Nicardipine; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Thymidine; Time Factors; Verapamil | 2001 |
Voltage-dependent calcium channels in the rat retina: involvement in NMDA-stimulated influx of calcium.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Calcium Channels, P-Type; Calcium Channels, Q-Type; Diltiazem; Dizocilpine Maleate; Dose-Response Relationship, Drug; N-Methylaspartate; Nifedipine; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Retina; Tetrodotoxin; Verapamil | 2001 |
Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs.
Topics: Animals; Atrial Fibrillation; Autonomic Nervous System; Calcium; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Heart Conduction System; Refractory Period, Electrophysiological; Vasodilator Agents; Verapamil | 2001 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Effects of nifedipine, verapamil, diltiazem and trifluoperazine on the antinociceptive activity of acetaminophen.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Calcium Channel Blockers; Cell Fractionation; Diltiazem; Dopamine Antagonists; Drug Synergism; Liver; Male; Mice; Nifedipine; Pain Measurement; Trifluoperazine; Verapamil | 2000 |
Relationship between extra and intracellular sources of calcium and the contractile effect of thiopental in rat aorta.
Topics: Animals; Aorta; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; Endothelium, Vascular; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Wistar; Thiopental; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 2001 |
Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes.
Topics: Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Microsomes, Liver; Simvastatin; Verapamil | 2001 |
Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac.
Topics: Aequorin; Age Factors; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Membrane; Cobalt; Diltiazem; Drosophila; Drosophila Proteins; Enzyme Inhibitors; GABA Agonists; Genes, Reporter; Ionophores; Membrane Potentials; Memory; Muscimol; Mutation; Nervous System; Neurons; Neuropeptides; Nicotinic Agonists; Quinidine; Tetrodotoxin; Thapsigargin; Verapamil; Veratridine | 2001 |
NAADP receptors are present and functional in the heart.
Topics: Adenosine Diphosphate Ribose; Animals; Calcium; Calcium Channel Blockers; Cyclic ADP-Ribose; Diltiazem; Indicators and Reagents; Kinetics; Microsomes; Myocardium; NADP; Protein Binding; Radioligand Assay; Receptors, Cell Surface; Ruthenium Red; Ryanodine; Verapamil | 2001 |
Involvement of calcium ion in the stimulated shoot elongation of arrowhead tubers under anaerobic conditions.
Topics: Anaerobiosis; Calcium; Calcium Channel Blockers; Calcium Chloride; Calcium Radioisotopes; Cell Division; Diltiazem; Egtazic Acid; Lanthanum; Magnoliopsida; Oxygen; Plant Shoots; Verapamil | 2001 |
Ca2+-antagonists inhibit the N-methyltransferase-dependent synthesis of phosphatidylcholine in the heart.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Dose-Response Relationship, Drug; Heart; Male; Methylation; Methyltransferases; Mitochondria, Heart; Myocardium; Organ Culture Techniques; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Sarcolemma; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Verapamil | 2001 |
Reversal of preexisting vasospasm in coronary artery conduits.
Topics: Arteries; Calcium Channel Blockers; Coronary Artery Bypass; Coronary Disease; Culture Techniques; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Occlusion, Vascular; Humans; Nicardipine; Nifedipine; Nitroglycerin; Vasoconstriction; Vasodilation; Veins; Verapamil | 2001 |
Calcium channel antagonists inhibit growth of subcutaneous xenograft meningiomas in nude mice.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Calcium Channel Blockers; Collagen; Diltiazem; Dose-Response Relationship, Drug; Drug Combinations; Humans; Immunohistochemistry; Ki-67 Antigen; Laminin; Male; Meningeal Neoplasms; Meningioma; Mice; Mice, Nude; Proteoglycans; Transplantation, Heterologous; Verapamil | 2001 |
Right vagal nerve stimulation for coronary anastomosis without cardiopulmonary bypass: investigation in dogs.
Topics: Anastomosis, Surgical; Animals; Cardiovascular Agents; Coronary Vessels; Diltiazem; Dogs; Electric Stimulation; Electrocardiography; Heart Rate; Intraoperative Period; Minimally Invasive Surgical Procedures; Thoracic Nerves; Vagus Nerve; Verapamil | 2001 |
Inhibitory effects of calcium channel blockers on thyroid hormone uptake in neonatal rat cardiomyocytes.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane; Cells, Cultured; Diltiazem; Iodine Radioisotopes; Muscle Fibers, Skeletal; Myocardium; Nifedipine; Potassium; Rats; Rats, Wistar; Thyroxine; Triiodothyronine; Verapamil | 2001 |
Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore.
Topics: Adult; Alkaloids; Androstadienes; Benzophenanthridines; Blood Platelets; Calcimycin; Calcium Channel Blockers; Cyproheptadine; Diltiazem; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Estrenes; Female; Genistein; Humans; In Vitro Techniques; Ionophores; Male; Methysergide; Phenanthridines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Pyrrolidinones; Second Messenger Systems; Serotonin; Type C Phospholipases; Verapamil; Wortmannin | 2001 |
Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.
Topics: Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Estrenes; Flavonoids; Humans; In Vitro Techniques; Indomethacin; Kinetics; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Pyrrolidinones; Serotonin; Thromboxane A2; Verapamil | 2001 |
Calcium channel blockers as first line treatment for broad complex tachycardia with right bundle branch block: ingenuity or folly?
Topics: Adult; Bundle-Branch Block; Calcium Channel Blockers; Diltiazem; Electrocardiography; Emergency Treatment; Female; Humans; Infusions, Intravenous; Male; Retrospective Studies; Tachycardia, Ventricular; Verapamil | 2002 |
Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders.
Topics: Adult; Aged; Analysis of Variance; Anticonvulsants; Calcium Channel Blockers; Cell Culture Techniques; Cell Division; Collagen; Diltiazem; DNA; ErbB Receptors; Female; Fibroblasts; Flow Cytometry; Gingiva; Gingival Overgrowth; Humans; Male; Middle Aged; Nicardipine; Nifedipine; Nisoldipine; Phenytoin; Radiopharmaceuticals; Statistics as Topic; Tritium; Verapamil | 2001 |
Effect of 17beta-estradiol exposure on vasorelaxation induced by K(+) channel openers and Ca(2+) channel blockers.
Topics: Animals; Calcium Channel Blockers; Cromakalim; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; In Vitro Techniques; Male; Mesenteric Arteries; Nifedipine; Pinacidil; Potassium Channels; Progesterone; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents; Verapamil | 2002 |
Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Immunologic; Focal Adhesion Kinase 2; Lipopolysaccharides; Macrophages, Alveolar; Mitogen-Activated Protein Kinases; NF-kappa B; Protein-Tyrosine Kinases; Rabbits; Sepsis; Signal Transduction; Transcription Factor AP-1; Tumor Necrosis Factor-alpha; Verapamil | 2002 |
Prior calcium channel blockade and short-term survival following acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Australia; Calcium Channel Blockers; Diltiazem; Drug Interactions; Female; Humans; Male; Middle Aged; Myocardial Infarction; Nifedipine; Odds Ratio; Retrospective Studies; Survival Rate; Time Factors; Treatment Outcome; Verapamil | 2001 |
Channels involved in transient currents unmasked by removal of extracellular calcium in cardiac cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cesium; Chelating Agents; Diltiazem; Drug Resistance; Egtazic Acid; Electric Conductivity; Heart Ventricles; Isoproterenol; Kinetics; Magnesium; Membrane Potentials; Myocardium; Nifedipine; Patch-Clamp Techniques; Potassium; Receptors, Adrenergic, beta; Swine; Verapamil | 2002 |
Studies on the interactions between the angiotensin converting enzyme inhibitor enalaprilat and calcium antagonists in rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; Cinnarizine; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Enalaprilat; Felodipine; Female; Male; Models, Animal; Models, Cardiovascular; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Potentiation of analgesia and reversal of tolerance to morphine by calcium channel blockers.
Topics: Analgesia; Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Drug Tolerance; Female; Flunarizine; Male; Mice; Morphine; Nimodipine; Pain Threshold; Verapamil | 2001 |
Pharmacoepidemiologic detection of calcium channel blocker-induced change on digoxin clearance using multiple trough screen analysis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Calcium Channel Blockers; Creatinine; Digoxin; Diltiazem; Drug Interactions; Female; Heart Failure; Humans; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Models, Statistical; Nifedipine; Pharmacoepidemiology; Regression Analysis; Reproducibility of Results; Spironolactone; Verapamil | 2002 |
Regulation of structural plasticity by different channel types in rod and cone photoreceptors.
Topics: Ambystoma; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Cobalt; Cyclic GMP; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; Eye Proteins; Ion Channels; Membrane Glycoproteins; Nerve Tissue Proteins; Neurites; Neuronal Plasticity; Nicardipine; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Rod Opsins; Synaptic Vesicles; Synaptophysin; Verapamil | 2002 |
Differential effects of organic calcium-channel blockers on diastolic SR calcium-handling in the frog heart.
Topics: Animals; Cadmium Chloride; Calcium; Calcium Channel Blockers; Diastole; Diltiazem; Heart Ventricles; In Vitro Techniques; Myocardial Contraction; Nifedipine; Ranidae; Sarcoplasmic Reticulum; Time Factors; Ventricular Function; Verapamil | 2002 |
Effects of cholesterol on dye leakage induced by multidrug-resistance modulators from anionic liposomes.
Topics: Acridines; Anions; Cholesterol; Coloring Agents; Detergents; Diltiazem; Drug Resistance, Multiple; Ethers; Liposomes; Octoxynol; Quinacrine; Rosaniline Dyes; Verapamil | 2003 |
A beta 25-35-induced depression of long-term potentiation in area CA1 in vivo and in vitro is attenuated by verapamil.
Topics: Amyloid beta-Peptides; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Electrophysiology; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Peptide Fragments; Rats; Rats, Wistar; Synaptic Transmission; Verapamil | 2003 |
Parkinsonian syndrome and calcium channel blockers.
Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Humans; Parkinsonian Disorders; Verapamil | 2003 |
High-affinity binding of [3H]DTZ323 to the diltiazem-binding site of L-type Ca2+ channels.
Topics: Alkaloids; Animals; Benzylisoquinolines; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Guinea Pigs; In Vitro Techniques; Male; Muscle, Skeletal; Myocardium; Nicardipine; Rabbits; Radioligand Assay; Time Factors; Verapamil | 2003 |
Effects of three different L-type Ca2+ entry blockers on airway constriction induced by muscarinic receptor stimulation.
Topics: Animals; Bronchoconstriction; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dogs; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Nicardipine; Nifedipine; Norepinephrine; Receptors, Muscarinic; Trachea; Verapamil | 2003 |
Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Caspase 3; Caspases; Cyclosporine; Cytochrome c Group; Cytoprotection; Diltiazem; Female; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Organometallic Compounds; Oxygen Consumption; Rats; Rats, Long-Evans; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Sodium-Calcium Exchanger; Verapamil | 2003 |
A biochromatographic framework to evaluate the calcium effect on the antihypertensive molecule-human serum albumin binding.
Topics: Antihypertensive Agents; Calcium; Chromatography, High Pressure Liquid; Diltiazem; Humans; Protein Binding; Serum Albumin; Verapamil | 2003 |
Modification of intracellular free calcium in cultured A10 vascular smooth muscle cells by exogenous phosphatidic acid.
Topics: Animals; Boron Compounds; Calcium; Carbamates; Cells, Cultured; Diltiazem; Drug Interactions; Egtazic Acid; Indoles; Macrocyclic Compounds; Maleimides; Muscle, Smooth, Vascular; Oxazoles; Pertussis Toxin; Phenylcarbamates; Phosphatidic Acids; Rats; Tetradecanoylphorbol Acetate; Thapsigargin; Verapamil | 2003 |
Planimetric and histological study of the aortae in atherosclerotic chickens treated with nifedipine, verapamil and diltiazem.
Topics: Animals; Aorta, Abdominal; Aorta, Thoracic; Arteriosclerosis; Calcium Channel Blockers; Chickens; Cholesterol, Dietary; Coloring Agents; Diet, Atherogenic; Diltiazem; Male; Microscopy, Electron; Nifedipine; Tissue Fixation; Verapamil | 2003 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method.
Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil | 2004 |
Particular sensitivity to calcium channel blockers of the fast inward voltage-dependent sodium current involved in the invasive properties of a metastastic breast cancer cell line.
Topics: Breast Neoplasms; Calcium Channel Blockers; Cell Division; Cell Line, Tumor; Cell Survival; Diltiazem; Electrophysiology; Female; Humans; Nifedipine; Potassium Channel Blockers; Sodium Channels; Tetraethylammonium; Tetrodotoxin; Verapamil | 2004 |
Endothelin-1 promotes Ca2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C.
Topics: Animals; Calcium; Calcium Channel Blockers; Coronary Vasospasm; Coronary Vessels; Diltiazem; Disease Models, Animal; Drug Resistance; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Naphthalenes; Peptide Fragments; Protein Kinase C; Protein Kinase C-epsilon; Protein Transport; Signal Transduction; Swine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil | 2004 |
[The effect of Ca2+ channel blocker on insulin secretion in rat pancreatic islet cells].
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Insulin; Insulin Secretion; Islets of Langerhans; Nifedipine; Rats; Rats, Sprague-Dawley; Verapamil | 2004 |
Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice.
Topics: Analgesia; Animals; Area Under Curve; Brain; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Nimodipine; Pain; Pain Measurement; Physical Stimulation; Tissue Distribution; Verapamil | 2004 |
ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells.
Topics: Adult; Animals; Antigens, CD34; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Centrifugation; Diltiazem; Genetic Therapy; Genetic Vectors; HeLa Cells; Hematopoietic Stem Cells; Humans; Lentivirus; Mice; Mice, Inbred NOD; Mice, SCID; Quinidine; Transduction, Genetic; Verapamil | 2004 |
Novel effect of Y-24180, a presumed specific platelet activation factor receptor antagonist, on Ca2+ levels and growth of human prostate cancer cells.
Topics: Adenosine Triphosphate; Azepines; Calcium; Calcium Signaling; Cell Proliferation; Dihydropyridines; Diltiazem; Enzyme Inhibitors; Fura-2; Humans; Male; Phorbol Esters; Platelet Membrane Glycoproteins; Prostatic Neoplasms; Protein Kinase C; Receptors, G-Protein-Coupled; Signal Transduction; Thapsigargin; Triazoles; Tumor Cells, Cultured; Verapamil | 2004 |
L-type Ca2+ channel antagonists block voltage-dependent Ca2+ channels in identified leech neurons.
Topics: Animals; Caffeine; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Gallopamil; Leeches; Membrane Potentials; Neurons; Nifedipine; Phosphodiesterase Inhibitors; Verapamil | 2004 |
Drug-induced atrioventricular block: prognosis after discontinuation of the culprit drug.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Calcium Channel Blockers; Diltiazem; Electrocardiography; Female; Follow-Up Studies; Heart Block; Humans; Hypertension; Israel; Male; Middle Aged; Prospective Studies; Treatment Failure; Verapamil | 2004 |
Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats.
Topics: Aminoquinolines; Animals; Calcium; Calcium Channels, L-Type; Calcium Channels, T-Type; Calcium Signaling; Diltiazem; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Mesenteric Arteries; Mibefradil; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxides; Verapamil | 2004 |
Different effects of calcium channel blockers on matrix metalloproteinase-2 expression in cultured rat cardiac fibroblasts.
Topics: Amlodipine; Animals; Animals, Newborn; Benzoquinones; Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Fibroblasts; Genistein; Lactams, Macrocyclic; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Myocardium; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitroprusside; Protein Kinase Inhibitors; Quinones; Rats; Rats, Wistar; Rifabutin; Verapamil | 2004 |
Involvement of L-type Ca2+ channels in the induction of long-term potentiation in the basolateral amygdala-dentate gyrus pathway of anesthetized rats.
Topics: Amygdala; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Dentate Gyrus; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Long-Term Potentiation; Male; Neural Pathways; Rats; Rats, Wistar; Verapamil | 2004 |
Oral erythromycin and the risk of sudden death from cardiac causes.
Topics: Administration, Oral; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Confounding Factors, Epidemiologic; Cytochrome P-450 CYP3A; Death, Sudden, Cardiac; Diltiazem; Drug Interactions; Erythromycin; Female; Humans; Male; Middle Aged; Multivariate Analysis; Nitroimidazoles; Oxidoreductases, N-Demethylating; Risk; Troleandomycin; Verapamil | 2004 |
Effect of glycyrrhizic acid on protein binding of diltiazem, verapamil, and nifedipine.
Topics: Diltiazem; Glycyrrhizic Acid; Humans; Male; Nifedipine; Protein Binding; Serum Albumin; Verapamil | 2004 |
[Severe pulmonary complications of massive intoxication with calcium channel blockers and isosorbide mononitrate--a case report].
Topics: Adult; Calcium Channel Blockers; Diltiazem; Humans; Isosorbide Dinitrate; Male; Respiratory Distress Syndrome; Suicide, Attempted; Treatment Outcome; Vasodilator Agents; Verapamil | 2004 |
Mechanisms of low Na+-induced increase in intracellular calcium in KCl-depolarized rat cardiomyocytes.
Topics: Amiloride; Animals; Calcium; Calcium Channels, L-Type; Diltiazem; Fluorescent Dyes; Fura-2; In Vitro Techniques; Intracellular Fluid; Male; Membrane Potentials; Myocytes, Cardiac; Nickel; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Sodium; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Verapamil | 2004 |
Case studies in hypertension. Dihydropyridine/nondihydropyridine calcium channel blocker combination therapy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Female; Humans; Hypertension; Lisinopril; Male; Middle Aged; Nifedipine; Verapamil | 2005 |
Adult hypertension: reducing cardiovascular morbidity and mortality.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Alcohol Drinking; Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Cardiovascular Diseases; Diabetes Complications; Diltiazem; Diuretics; Drug Evaluation; Health Behavior; Humans; Hypertension; Losartan; Obesity; Renal Insufficiency; Sodium; Stroke; Verapamil | 2005 |
Prevalence and risk of gingival overgrowth in patients treated with diltiazem or verapamil.
Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Cross-Sectional Studies; Dental Plaque Index; Diltiazem; Female; Gingival Overgrowth; Gingivitis; Humans; Male; Middle Aged; Periodontal Index; Periodontal Pocket; Risk Factors; Verapamil | 2005 |
Induction of contracture and extracellular Ca2+ influx in cardiac muscle by sanguinarine: a study on cardiotoxicity of sanguinarine.
Topics: Alkaloids; Amiloride; Animals; Antioxidants; Benzophenanthridines; Calcium; Calcium Channels; Cardiotonic Agents; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Egtazic Acid; Heart; Heart Ventricles; Isoquinolines; Lanthanum; Lipid Peroxidation; Male; Manganese; Myocardium; Nickel; Nifedipine; Rats; Rats, Wistar; Time Factors; Verapamil | 2005 |
Simultaneous measurements of cytoplasmic Ca2+ responses and intracellular pH in neutrophils of localized aggressive periodontitis (LAP) patients.
Topics: Aggressive Periodontitis; Calcium; Cytokines; Cytoplasm; Diltiazem; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; Imidazoles; Interleukin-8; Intracellular Fluid; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nifedipine; Substance P; Time Factors; Verapamil | 2005 |
Excessive activation of cyclic nucleotide-gated channels contributes to neuronal degeneration of photoreceptors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Blotting, Western; Cadmium Chloride; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; In Situ Nick-End Labeling; In Vitro Techniques; Ion Channels; Mice; Mice, Mutant Strains; Nerve Degeneration; Neuroglia; Phosphodiesterase Inhibitors; Photoreceptor Cells; Purinones; Rats; Rats, Wistar; Swine; Verapamil | 2005 |
Drug release from complexes with a series of poly(carboxyalkyl methacrylates), a new class of weak polyelectrolytes.
Topics: Cations; Delayed-Action Preparations; Diltiazem; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Osmolar Concentration; Polyamines; Polyelectrolytes; Polymethacrylic Acids; Propranolol; Solubility; Structure-Activity Relationship; Tablets; Temperature; Verapamil | 2005 |
The comparative effects of calcium channel blockers in an experimental colitis model in rats.
Topics: Animals; Calcium Channel Blockers; Colitis; Diltiazem; Disease Models, Animal; Drug Administration Schedule; Male; Peroxidase; Rats; Verapamil | 2004 |
Role of voltage-sensitive calcium-channels in nitric oxide-mediated vasodilation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Cysteine; Diltiazem; Hindlimb; Hydrazines; Male; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; S-Nitrosothiols; Vascular Resistance; Vasodilation; Vasodilator Agents; Verapamil | 2005 |
Effects of diltiazem or verapamil on calcium uptake and release from chicken skeletal muscle sarcoplasmic reticulum.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Chickens; Diltiazem; In Vitro Techniques; Microsomes; Muscle, Skeletal; Sarcoplasmic Reticulum; Silver Nitrate; Verapamil | 2005 |
Inhibitory effects of various L-type and T-type calcium antagonists on electrically generated, potassium-induced and carbachol-induced contractions of porcine detrusor muscle.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Carbachol; Cholinergic Agents; Diltiazem; Electric Stimulation; Female; Muscle Contraction; Muscle, Smooth; Nifedipine; Potassium; Swine; Urinary Bladder; Verapamil | 2006 |
Potentiating effects of L-type Ca(2+) channel blockers on pentobarbital-induced hypnosis are influenced by serotonergic system.
Topics: 5-Hydroxytryptophan; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fenclonine; Hypnotics and Sedatives; Male; Mice; Mice, Inbred ICR; Nifedipine; Pentobarbital; Serotonin; Serotonin Antagonists; Sleep; Verapamil | 2006 |
Inhibitory effects of L- and T-type calcium antagonists on contractions of human detrusor muscle.
Topics: Adult; Aged; Analysis of Variance; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Carbachol; Diltiazem; Female; Humans; In Vitro Techniques; Male; Mibefradil; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Nimodipine; Potassium; Urinary Bladder; Verapamil | 2006 |
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil | 2006 |
High sensitivity of chicken's skeletal muscle sarcoplasmatic reticulum to effects of diltiazem or verapamil on calcium uptake and release.
Topics: Adenosine Triphosphate; Animals; Anti-Bacterial Agents; Calcium; Calcium Channel Blockers; Chickens; Chlortetracycline; Diltiazem; Fluorescent Dyes; In Vitro Techniques; Microscopy, Fluorescence; Muscle, Skeletal; Sarcoplasmic Reticulum; Verapamil | 2006 |
[Characteristics of action of various drugs blocking atrioventricular conduction (beta-blockers, verapamil, diltiazem) in constant fibrillation tachyarrhythmia. Is monotherapy optimal?].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Treatment Outcome; Ventricular Fibrillation; Verapamil | 2006 |
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil | 2007 |
In vitro pharmacological characterization of mitemcinal (GM-611), the first acid-resistant non-peptide motilin receptor agonist, in smooth muscle of rabbit small intestine.
Topics: Acetylcholine; Animals; Atropine; Binding, Competitive; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Erythromycin; Hexamethonium; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Intestine, Small; Male; Molecular Structure; Muscle Contraction; Muscle, Smooth; Naloxone; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; Tetrodotoxin; Tropisetron; Verapamil | 2007 |
L-type calcium channels in growth plate chondrocytes participate in endochondral ossification.
Topics: Animals; Apoptosis; Bone and Bones; Calcium Channel Blockers; Calcium Channels, L-Type; Chondrocytes; Diltiazem; Growth Plate; Osteogenesis; Rats; Rats, Sprague-Dawley; Verapamil | 2007 |
Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Algorithms; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Felodipine; Ion Channel Gating; Male; Membrane Potentials; Models, Biological; Myocytes, Cardiac; Patch-Clamp Techniques; Protein Binding; Rats; Rats, Wistar; Verapamil | 2007 |
Binding activities by propiverine and its N-oxide metabolites of L-type calcium channel antagonist receptors in the rat bladder and brain.
Topics: Analysis of Variance; Animals; Benzilates; Brain; Calcium Channels, L-Type; Diltiazem; Isradipine; Male; Mandelic Acids; N-Methylscopolamine; Protein Binding; Rats; Rats, Sprague-Dawley; Tritium; Urinary Bladder; Verapamil | 2007 |
Effects of phenylalkylamines and benzothiazepines on Ca(v)1.3-mediated Ca2+ currents in neonatal mouse inner hair cells.
Topics: Algorithms; Animals; Animals, Newborn; Benzazepines; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Diltiazem; Dose-Response Relationship, Drug; Gallopamil; Hair Cells, Auditory, Inner; Membrane Potentials; Mice; Mice, Inbred Strains; Phenethylamines; Verapamil | 2007 |
What do medical records tell us about potentially harmful co-prescribing?
Topics: Adult; Ambulatory Care; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Anticoagulants; Antihypertensive Agents; Digoxin; Diltiazem; Drug Interactions; Drug Utilization Review; Health Maintenance Organizations; Humans; Lovastatin; Medical Audit; Medication Errors; Office Visits; Polypharmacy; United States; Verapamil; Warfarin | 2007 |
[The application of 4-aminopyridine in calcium channel inhibitors acute poisoning].
Topics: 4-Aminopyridine; Acute Disease; Adrenergic beta-Antagonists; Adult; Antidotes; Antihypertensive Agents; Calcium Channel Blockers; Diltiazem; Drug Overdose; Drug Therapy, Combination; Epinephrine; Female; Heart Rate; Humans; Hypotension; Myocardial Ischemia; Poisoning; Potassium Channel Blockers; Suicide, Attempted; Tachycardia, Supraventricular; Treatment Outcome; Vasoconstrictor Agents; Verapamil | 2007 |
Assessment of hyperglycemia after calcium channel blocker overdoses involving diltiazem or verapamil.
Topics: Adult; Aged; Blood Glucose; Calcium Channel Blockers; Diltiazem; Drug Overdose; Humans; Hyperglycemia; Middle Aged; Retrospective Studies; Severity of Illness Index; Verapamil | 2007 |
Calcium channel blockers increase the amount of nitrite production in rabbits without decreasing the responsiveness of platelets to collagen.
Topics: Animals; Calcium Channel Blockers; Collagen; Diltiazem; Male; Nicardipine; Nitric Oxide; Nitrites; Oxidation-Reduction; Platelet Aggregation; Rabbits; Verapamil | 2007 |
Inclusion of patients who overdose with dihydropyridine calcium channel blockers would potentially increase clinical utility of hyperglycemia.
Topics: Calcium Channel Blockers; Dihydropyridines; Diltiazem; Drug Overdose; Heart Rate; Humans; Hyperglycemia; Patient Selection; Verapamil | 2008 |
Protective effect of L-type calcium channel blockers against haloperidol-induced orofacial dyskinesia: a behavioural, biochemical and neurochemical study.
Topics: Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, L-Type; Corpus Striatum; Diltiazem; Dopamine; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Movement Disorders; Nifedipine; Nimodipine; Random Allocation; Rats; Rats, Wistar; Serotonin; Verapamil | 2008 |
Verapamil toxicity dysregulates the phosphatidylinositol 3-kinase pathway.
Topics: Adipocytes; Androstadienes; Animals; Blotting, Western; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Glucose; Insulin; Mice; Nifedipine; Phosphatidylinositol 3-Kinases; Signal Transduction; Verapamil; Wortmannin | 2008 |
Formulation of sustained-release verapamil HCl and diltiazem HCl semisolid matrix capsules.
Topics: Capsules; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diltiazem; Solubility; Verapamil | 2008 |
Effects of amlodipine, diltiazem, and verapamil on the anticonvulsant action of topiramate against maximal electroshock-induced seizures in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Behavior, Animal; Brain; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electroshock; Fluorescence Polarization Immunoassay; Fructose; Mice; Motor Skills; Seizures; Topiramate; Verapamil | 2008 |
Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase.
Topics: Animals; Behavior, Animal; Burns; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Diltiazem; Enzyme Inhibitors; Hyperalgesia; Ibuprofen; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-Conotoxins; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spinal Cord; Verapamil | 2008 |
Mixed-mode reversed-phase and ion-exchange monolithic columns for micro-HPLC.
Topics: Acrylates; Amitriptyline; Aniline Compounds; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Diltiazem; Hydrogen-Ion Concentration; Ketones; Methacrylates; Microchemistry; Molecular Structure; Particle Size; Phenols; Polycyclic Aromatic Hydrocarbons; Polymers; Porosity; Pyrazines; Quinine; Reproducibility of Results; Sensitivity and Specificity; Stearates; Surface Properties; Time Factors; Verapamil | 2008 |
Effect of nifedipine on capacitive calcium entry in Jurkat T lymphocytes.
Topics: Antibodies; Biological Transport, Active; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; CD3 Complex; Cell Membrane; Cell Membrane Permeability; Cytoplasm; Diltiazem; Humans; Ionomycin; Jurkat Cells; Membrane Potentials; Nifedipine; Phytohemagglutinins; Thapsigargin; Verapamil | 2009 |
Ion-channel blocker sensitivity of voltage-gated calcium-channel homologue Cch1 in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Humans; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Mutation; Nifedipine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Up-Regulation; Verapamil | 2008 |
Role of Ca2+ mobilization and Ca2+ sensitization in 8-iso-PGF 2 alpha-induced contraction in airway smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Bridged-Ring Compounds; Calcium Channel Blockers; Calcium Signaling; Diltiazem; Dinoprost; Dioxanes; Enzyme Inhibitors; Estrenes; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Norbornanes; Pyridines; Pyrrolidinones; Receptors, Thromboxane A2, Prostaglandin H2; rho-Associated Kinases; Signal Transduction; Thiocarbamates; Thiones; Trachea; Type C Phospholipases; Vasoconstrictor Agents; Verapamil | 2009 |
Diltiazem and verapamil protect dystrophin-deficient muscle fibers of MDX mice from degeneration: a potential role in calcium buffering and sarcolemmal stability.
Topics: Animals; Calcium; Calcium Channel Blockers; Calsequestrin; Creatine Kinase; Diltiazem; Disease Models, Animal; Dystroglycans; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscular Dystrophy, Animal; Sarcolemma; Verapamil | 2009 |
Diltiazem, a L-type Ca(2+) channel blocker, also acts as a pharmacological chaperone in Gaucher patient cells.
Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Diltiazem; Dose-Response Relationship, Drug; Enzyme Activation; Fibroblasts; Gaucher Disease; Glucosylceramidase; Hot Temperature; Humans; Hydrogen-Ion Concentration; Imino Pyranoses; Lysosomes; Phenotype; Verapamil | 2009 |
Drug interactions between inhaled corticosteroids and enzymatic inhibitors.
Topics: Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adrenal Insufficiency; Adult; Aged; Anti-Asthmatic Agents; Asthma; Child; Cushing Syndrome; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Incidence; Itraconazole; Male; Middle Aged; Retrospective Studies; Ritonavir; Verapamil | 2009 |
L-type voltage-dependent calcium channel antagonists impair perirhinal long-term recognition memory and plasticity processes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Neurons; Nifedipine; Proto-Oncogene Proteins c-fos; Rats; Recognition, Psychology; Synapses; Temporal Lobe; Time Factors; Verapamil | 2009 |
Rapid large artery remodeling following the administration and withdrawal of calcium channel blockers in spontaneously hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Calcium Channel Blockers; Diltiazem; Endothelium; Hypertension; Male; Muscle Contraction; Nifedipine; Rats; Time Factors; Verapamil | 2009 |
In vivo and ex vivo evaluation of L-type calcium channel blockers on acid beta-glucosidase in Gaucher disease mouse models.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Disease Models, Animal; Fibroblasts; Gaucher Disease; Glucosylceramidase; Homozygote; Mice; Mice, Transgenic; Models, Biological; Mutation; Skin; Verapamil | 2009 |
Calcium channel blockers differentially modulate cytokine production by peripheral blood mononuclear cells.
Topics: Amlodipine; Calcium Channel Blockers; Cytokines; Diltiazem; Humans; In Vitro Techniques; Interferon-gamma; Interleukin-1alpha; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Nifedipine; Tumor Necrosis Factor-alpha; Verapamil | 2010 |
Participation of L-type calcium channels in ethanol-induced behavioral stimulation and motor incoordination: effects of diltiazem and verapamil.
Topics: Analysis of Variance; Animals; Ataxia; Behavior, Animal; Caffeine; Calcium Channel Blockers; Calcium Channels, L-Type; Central Nervous System Stimulants; Cocaine; Diltiazem; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Motor Activity; Rotarod Performance Test; Verapamil | 2010 |
Endoplasmic reticulum Ca2+ increases enhance mutant glucocerebrosidase proteostasis.
Topics: Amino Acid Substitution; Calcium; Calcium Channel Blockers; Diltiazem; Endoplasmic Reticulum; Gaucher Disease; Glucosylceramidase; Humans; Lysosomes; Protein Folding; Protein Processing, Post-Translational; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Vasodilator Agents; Verapamil | 2010 |
The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat.
Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Injections, Spinal; Male; Mepivacaine; Rats; Rats, Sprague-Dawley; Verapamil | 2010 |
Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Calcium Signaling; Calsequestrin; Diltiazem; Disease Models, Animal; Electrocardiography; Gene Knock-In Techniques; Magnesium; Mice; Mice, Knockout; Mutation; Myocytes, Cardiac; Propranolol; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Tachycardia, Ventricular; Time Factors; Verapamil | 2011 |
The relationship between the drug concentration profiles in plasma and the drug doses in the colon.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Area Under Curve; Biological Availability; Colon; Delayed-Action Preparations; Diclofenac; Diltiazem; Dogs; Dose-Response Relationship, Drug; Hypoglycemic Agents; Metformin; Muscarinic Agonists; Quinuclidines; Terfenadine; Thiophenes; Verapamil | 2010 |
Attenuation of proinflammatory cytokines and apoptotic process by verapamil and diltiazem against quinolinic acid induced Huntington like alterations in rats.
Topics: Analysis of Variance; Animals; Apoptosis; Body Weight; Calcium Channel Blockers; Catalase; Cytokines; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Huntington Disease; Lipid Peroxidation; Male; Motor Activity; Nitrites; Psychomotor Performance; Quinolinic Acid; Rats; Rats, Wistar; Verapamil | 2011 |
Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells.
Topics: Adrenocortical Carcinoma; Angiotensin II; Bucladesine; Calcium Channel Blockers; Cell Line, Tumor; Dehydroepiandrosterone Sulfate; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hydrocortisone; Nitrophenols; Organophosphorus Compounds; Phosphoproteins; RNA, Messenger; Verapamil | 2011 |
Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.
Topics: Cryopreservation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Erythromycin; Hepatocytes; Humans; Microsomes, Liver; Pharmacokinetics; Risk Assessment; Time Factors; Troleandomycin; Verapamil | 2011 |
Ionotropic glutamate receptor (iGluR)-like channels mediate MAMP-induced calcium influx in Arabidopsis thaliana.
Topics: Aequorin; Alloxan; Arabidopsis; Arabidopsis Proteins; Bacterial Proteins; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Chitin; Dideoxyadenosine; Diltiazem; Enzyme Activation; Estrenes; Gene Expression Regulation, Plant; Kynurenic Acid; Mitogen-Activated Protein Kinases; Neomycin; Nifedipine; Plants, Genetically Modified; Pyrrolidinones; Receptors, Ionotropic Glutamate; Receptors, Pattern Recognition; Seedlings; Transcription, Genetic; Type C Phospholipases; Verapamil | 2011 |
Extracorporeal albumin dialysis in three cases of acute calcium channel blocker poisoning with life-threatening refractory cardiogenic shock.
Topics: Adolescent; Albumins; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Drug Overdose; Female; Humans; Male; Middle Aged; Renal Dialysis; Shock, Cardiogenic; Verapamil | 2012 |
L-type calcium channel mediates anticonvulsant effect of cannabinoids in acute and chronic murine models of seizure.
Topics: Acute Disease; Animals; Anticonvulsants; Benzamides; Benzoxazines; Calcium Channels, L-Type; Cannabinoids; Carbamates; Chronic Disease; Diltiazem; Disease Models, Animal; Kindling, Neurologic; Male; Mice; Morpholines; Naphthalenes; Rats; Rats, Wistar; Seizures; Verapamil | 2012 |
Calcium channel antagonist exposures reported to the Poisons Information Center Erfurt.
Topics: Adolescent; Adult; Age Distribution; Aged; Calcium Channel Blockers; Child; Dihydropyridines; Diltiazem; Drug Overdose; Drug Synergism; Germany; Humans; Infant; Middle Aged; Poison Control Centers; Retrospective Studies; Verapamil; Young Adult | 2011 |
pH Sensitive graft copolymers for zero order drug release: a mechanistic analysis.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Dicarboxylic Acids; Diffusion; Diltiazem; Dosage Forms; Epoxy Compounds; Hydrogen-Ion Concentration; Indomethacin; Methacrylates; Microspheres; Particle Size; Pharmacokinetics; Polyesters; Polymers; Solubility; Tablets; Verapamil | 2012 |
Treatment of calcium channel blocker-induced cardiovascular toxicity with drug scavenging liposomes.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Drug Carriers; Hydrogen-Ion Concentration; Injections, Intravenous; Kinetics; Liposomes; Male; Rats; Rats, Sprague-Dawley; Time Factors; Verapamil | 2012 |
Copper-induced intracellular calcium release requires extracellular calcium entry and activation of L-type voltage-dependent calcium channels in Ulva compressa.
Topics: Calcium; Calcium Channels, L-Type; Calcium Signaling; Copper; Diltiazem; Extracellular Space; Intracellular Space; Ion Channel Gating; Models, Biological; Neomycin; Nifedipine; Ulva; Verapamil | 2012 |
[The choked heart].
Topics: Adrenergic beta-Antagonists; Aged; Atrial Fibrillation; Bisoprolol; Calcium Channel Blockers; Cardiac Output, Low; Diagnosis, Differential; Diltiazem; Disease Progression; Dose-Response Relationship, Drug; Drug Interactions; Emergencies; Female; Humans; Shock, Cardiogenic; Verapamil | 2012 |
Non-ionic contrast media induces oxidative stress and apoptosis through Ca²⁺ influx in human neutrophils.
Topics: Adult; Apoptosis; beta Carotene; Boron Compounds; Calcium; Calcium Channel Blockers; Caspases; Cells, Cultured; Contrast Media; Diltiazem; Female; Glutathione; Glutathione Peroxidase; Humans; Iohexol; Ion Transport; Lipid Peroxidation; Male; Middle Aged; Migraine Disorders; Neutrophils; Oxidative Stress; TRPM Cation Channels; Verapamil; Vitamin E | 2012 |
[Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy].
Topics: Adrenergic beta-Agonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Digoxin; Diltiazem; Heart Diseases; Heart Rate; Humans; Hypertension; Ivabradine; Verapamil | 2012 |
Lipid peroxidation is another potential mechanism besides pore-formation underlying hemolysis of tentacle extract from the jellyfish Cyanea capillata.
Topics: Animals; Antioxidants; Ascorbic Acid; Calcium; Calcium Channel Blockers; Cnidarian Venoms; Diltiazem; Erythrocyte Membrane; Erythrocytes; Glutathione; Hemolysis; Lipid Peroxidation; Male; Malondialdehyde; Nifedipine; Osmosis; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Scyphozoa; Verapamil | 2013 |
What is the best treatment for acute calcium channel blocker overdose?
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2013 |
Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.
Topics: Adolescent; Adult; Aged; Arizona; Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Retrospective Studies; Vasoconstrictor Agents; Verapamil; Young Adult | 2013 |
Evaluation of the inhibitory effects of antihypertensive drugs on human carboxylesterase in vitro.
Topics: Antihypertensive Agents; Benzimidazoles; Benzoates; Carboxylesterase; Diltiazem; Drug Interactions; Humans; Imidazolidines; Liver; Nitrendipine; Telmisartan; Verapamil | 2013 |
Ferutinin induces in vitro eryptosis/erythroptosis in human erythrocytes through membrane permeabilization and calcium influx.
Topics: Apoptosis; Benzoates; Bridged Bicyclo Compounds; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, P-Type; Caspase 3; Cell Membrane Permeability; Cycloheptanes; Diltiazem; Erythrocytes; Ferula; Humans; Plant Roots; Sesquiterpenes; Up-Regulation; Verapamil | 2013 |
Annals of Emergency Medicine Journal Club. Treatment of calcium channel blocker poisoning: should we re-prioritize our potpourri of treatment options?
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2013 |
The role of L-type calcium channels in the development and expression of behavioral sensitization to ethanol.
Topics: Animals; Behavior, Addictive; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Ethanol; Male; Mice; Mice, Inbred DBA; Motor Activity; Nifedipine; Verapamil | 2013 |
Modulation of oxidative stress, apoptosis, and calcium entry in leukocytes of patients with multiple sclerosis by Hypericum perforatum.
Topics: Adult; Apoptosis; Ascorbic Acid; beta Carotene; Calcium; Calcium Channel Blockers; Case-Control Studies; Cells, Cultured; Diltiazem; Female; Glutathione; Glutathione Peroxidase; Humans; Hypericum; Lipid Peroxidation; Male; Middle Aged; Multiple Sclerosis; Neutrophils; Oxidative Stress; Plant Extracts; Verapamil; Vitamin A; Vitamin E; Young Adult | 2014 |
In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Carboxylesterase; Carboxylic Ester Hydrolases; Diltiazem; Drug Interactions; Enalapril; Esters; Humans; Hydrolysis; Inactivation, Metabolic; Indoles; Kinetics; Liver; Microsomes, Liver; Nitrophenols; Prodrugs; Ramipril; Recombinant Proteins; Verapamil | 2014 |
Protective effect of selected calcium channel blockers and prednisolone, a phospholipase-A2 inhibitor, against gentamicin and carbon tetrachloride-induced nephrotoxicity.
Topics: Animals; Antioxidants; Biomarkers; Calcium Channel Blockers; Carbon Tetrachloride; Cytoprotection; Diltiazem; Disease Models, Animal; Gentamicins; Kidney; Kidney Diseases; Lipid Peroxidation; Male; Nifedipine; Oxidative Stress; Phospholipase A2 Inhibitors; Prednisolone; Rats, Wistar; Time Factors; Verapamil | 2014 |
Non-steroidal anti-inflammatory drug modulates oxidative stress and calcium ion levels in the neutrophils of patients with primary dysmenorrhea.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Boron Compounds; Calcium; Calcium Channels; Cells, Cultured; Diclofenac; Diltiazem; Dysmenorrhea; Female; Glutathione Peroxidase; Humans; Lipid Peroxidation; Neutrophil Activation; Neutrophils; Oxidative Stress; Verapamil; Young Adult | 2013 |
Ischemia complications after calcium channel blocker poisoning.
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2014 |
In reply.
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2014 |
Critical care management of verapamil and diltiazem overdose with a focus on vasopressors: a 25-year experience at a single center.
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2014 |
Insulin for calcium channel toxicity.
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2014 |
In reply.
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2014 |
Annals of Emergency Medicine Journal Club. Treatment of calcium channel blocker poisoning: should we reprioritize our potpourri of treatment options?: answers to the September 2013 Journal Club questions.
Topics: Calcium Channel Blockers; Critical Care; Diltiazem; Drug Overdose; Female; Humans; Male; Vasoconstrictor Agents; Verapamil | 2014 |
The aversive, anxiolytic-like, and verapamil-sensitive psychostimulant effects of pulegone.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Stimulants; Choice Behavior; Conditioning, Psychological; Cyclohexane Monoterpenes; Diltiazem; Drug Interactions; Flumazenil; Grooming; Haloperidol; Hand Strength; Male; Maze Learning; Menthol; Mice; Monoterpenes; Motor Activity; Picrotoxin; Reinforcement, Psychology; Rotarod Performance Test; Verapamil | 2014 |
A stitch in time.
Topics: Angioplasty, Balloon, Coronary; Diltiazem; Female; Humans; Isosorbide Dinitrate; Male; Radial Artery; Spasm; Verapamil | 2014 |
Degradation kinetics and pathways of three calcium channel blockers under UV irradiation.
Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Disinfection; Kinetics; Photolysis; Ultraviolet Rays; Verapamil; Wastewater; Water Pollutants, Chemical | 2015 |
Suppressive effects of diltiazem and verapamil on delayed rectifier K(+)-channel currents in murine thymocytes.
Topics: Animals; Calcium Channel Blockers; Cell Membrane; Delayed Rectifier Potassium Channels; Diltiazem; Kv1.3 Potassium Channel; Male; Membrane Potentials; Mice; Patch-Clamp Techniques; Thymocytes; Verapamil | 2015 |
Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Cell Line; Collagen; Deferoxamine; Diltiazem; Hepatic Stellate Cells; Iron; Iron Overload; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Mice; Nimodipine; Rats; Tissue Inhibitor of Metalloproteinase-1; Verapamil | 2016 |
Gene expression profiling of calcium-channel antagonists in the heart of hypertensive and normotensive rats reveals class specific effects.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Gene Expression Profiling; Gene Expression Regulation; Hypertension; Hypertrophy, Left Ventricular; Male; Nifedipine; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Up-Regulation; Verapamil | 2016 |
CaV
Topics: Amygdala; Animals; Biophysics; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Functional Laterality; Male; Medial Forebrain Bundle; Rats; Rats, Long-Evans; Reward; Time Factors; Verapamil | 2017 |
Lipid emulsion alleviates the vasodilation and mean blood pressure decrease induced by a toxic dose of verapamil in isolated rat aortae and an in vivo rat model.
Topics: Animals; Aorta, Thoracic; Bepridil; Blood Pressure; Calcium Channel Blockers; Diltiazem; Emulsions; In Vitro Techniques; Male; Nifedipine; Phenylephrine; Phospholipids; Rats; Rats, Sprague-Dawley; Soybean Oil; Vasodilation; Vasodilator Agents; Verapamil | 2018 |
Postnatal developmental changes in the sensitivity of L-type Ca
Topics: Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Heart; Heart Ventricles; Hypotension; Mice; Mice, Inbred C57BL; Myocardium; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Perfusion; Risk; Time Factors; Verapamil | 2018 |
Evaluation of four calcium channel blockers as fluconazole resistance inhibitors in Candida glabrata.
Topics: Calcium Channel Blockers; Candida glabrata; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance, Fungal; Drug Synergism; Fluconazole; Microbial Sensitivity Tests; Microbial Viability; Nicardipine; Nifedipine; Verapamil | 2018 |
Selectivity of Ca
Topics: Animals; Antihypertensive Agents; Aorta; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Gastroesophageal Reflux; In Vitro Techniques; Male; Muscle Contraction; Nifedipine; Potassium Chloride; Rats, Wistar; Verapamil | 2018 |
Contact dermatitis caused by diltiazem cream and cross-reactivity with other calcium channel blockers.
Topics: Calcium Channel Blockers; Cross Reactions; Dermatitis, Allergic Contact; Diltiazem; Fissure in Ano; Humans; Male; Middle Aged; Nifedipine; Skin Cream; Verapamil | 2018 |
L-type calcium channel modulates mechanosensitivity of the cardiomyocyte cell line H9c2.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Indoles; Mechanotransduction, Cellular; Myocytes, Cardiac; Nifedipine; Rats; Thapsigargin; Verapamil | 2019 |
Identifying the Transcriptome Signatures of Calcium Channel Blockers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
Topics: Amlodipine; Calcium Channel Blockers; Cell Differentiation; Cells, Cultured; Diltiazem; Humans; Induced Pluripotent Stem Cells; Myocytes, Cardiac; Myosin Heavy Chains; Nifedipine; Transcriptome; Verapamil | 2019 |
Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amino Acid Sequence; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cryoelectron Microscopy; Diltiazem; Ligands; Male; Models, Molecular; Nifedipine; Rabbits; Verapamil | 2019 |
Structural Basis for Diltiazem Block of a Voltage-Gated Ca
Topics: Allosteric Regulation; Amlodipine; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Crystallography, X-Ray; Diltiazem; Humans; Models, Molecular; Protein Conformation; Verapamil | 2019 |
High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Topics: Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carvedilol; Chromatography, High Pressure Liquid; Diltiazem; Flecainide; High-Throughput Screening Assays; Humans; Lidocaine; Metoprolol; Propranolol; Reproducibility of Results; Sotalol; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Verapamil | 2019 |
Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling.
Topics: Administration, Oral; Adult; Aged; Alkynes; Aminopyridines; Area Under Curve; Benzimidazoles; Benzoxazines; Bosentan; Clarithromycin; Computer Simulation; Cyclin-Dependent Kinases; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Ketoconazole; Male; Middle Aged; Modafinil; Models, Biological; Rifampin; Verapamil | 2020 |
Association of Oral Anticoagulants and Verapamil or Diltiazem With Adverse Bleeding Events in Patients With Nonvalvular Atrial Fibrillation and Normal Kidney Function.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Databases, Factual; Diltiazem; Drug Interactions; Factor Xa Inhibitors; Female; Hemorrhage; Humans; Male; Middle Aged; Retrospective Studies; Verapamil | 2020 |
Comparative Efficacy and Safety of Intravenous Verapamil and Diltiazem for Rate Control in Rapidly Conducted Atrial Fibrillation and Atrial Flutter.
Topics: Administration, Intravenous; Atrial Fibrillation; Atrial Flutter; Diltiazem; Humans; Verapamil | 2020 |
Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring.
Topics: Amiodarone; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Computer Systems; Diltiazem; Drug Monitoring; Humans; Metoprolol; Pharmaceutical Preparations; Propafenone; Tandem Mass Spectrometry; Verapamil | 2020 |
In Esophageal Squamous Cells From Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion Through Effects on Intracellular Calcium and a Non-Gastric Proton Pump.
Topics: Biological Transport; Boron Compounds; Calcium; Calcium Channel Blockers; Cell Line; Chemokine CCL26; Diltiazem; Egtazic Acid; Eosinophilic Esophagitis; Epithelial Cells; Esophageal Mucosa; Famotidine; Female; H(+)-K(+)-Exchanging ATPase; Histamine H2 Antagonists; Humans; Interleukin-4 Receptor alpha Subunit; Male; Omeprazole; Primary Cell Culture; Proton Pump Inhibitors; Proton Pumps; Ranitidine; RNA, Messenger; Signal Transduction; Th2 Cells; Verapamil | 2021 |
Role of L-Type Voltage-Gated Calcium Channels in Epileptiform Activity of Neurons.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cells, Cultured; Diltiazem; Hippocampus; Membrane Potentials; Neurons; Rats; Rats, Sprague-Dawley; Verapamil | 2021 |
Calcium-channel-blockers exhibit divergent regulation of cancer extravasation through the mechanical properties of cancer cells and underlying vascular endothelial cells.
Topics: Calcium; Calcium Channel Blockers; Diltiazem; Endothelial Cells; Neoplasms; Nifedipine; Verapamil | 2022 |
Association of Nondihydropyridine Calcium Channel Blockers Versus β-Adrenergic Receptor Blockers With Risk of Heart Failure Hospitalization.
Topics: Adrenergic beta-Antagonists; Aged; Atrial Fibrillation; Calcium Channel Blockers; Diltiazem; Heart Failure; Hospitalization; Humans; Medicare; Receptors, Adrenergic, beta; Stroke Volume; United States; Verapamil | 2023 |
Safety of direct oral anticoagulant use in patients taking verapamil or diltiazem.
Topics: Administration, Oral; Anticoagulants; Calcium Channel Blockers; Diltiazem; Humans; Verapamil | 2023 |