Page last updated: 2024-08-23

diltiazem and theophylline

diltiazem has been researched along with theophylline in 69 studies

Research

Studies (69)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (26.09)	18.7374
1990's	17 (24.64)	18.2507
2000's	20 (28.99)	29.6817
2010's	13 (18.84)	24.3611
2020's	1 (1.45)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Gubernator, K; Kansy, M; Senner, F	1
Coassolo, P; Lavé, T; Schneider, G	1
Topliss, JG; Yoshida, F	1
Caron, G; Ermondi, G	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Akimoto, Y; Kiyomoto, A; Nakajima, H; Yamaguchi, I	1
Ikegami, K; Sakanashi, M; Ueda, S; Yonemura, KI	1
Branch, RA; Sabra, R	2
Jaffer, S; Mulholland, MW	1
Belonosov, SS; Chel'tsov, VV; Lepakhin, VK; Moiseev, VS; Rubtsova, II; Trufanova, LM	1
Cirillo, R; Franzone, JS; Reboani, MC	1
Baumelou, A; Baumelou, B; Cacoub, P; Deray, G; Jacobs, C; Martinez, F	1
Asai, K; Funaki, C; Hayashi, T; Kuzuya, F; Kuzuya, M; Naito, M	1
Haffner, CA; Kendall, MJ; Smith, SR	1
Cheng, KK; Chiang, BN; Hou, ZY; Lin, CI; Vassalle, M	1
Abadir, AR; Gintautas, J; Longmore, W; Mitra, P; Pillalamarri, ED	1
Adebayo, GI; Akintonwa, A; Mabadeje, AF	1
McGraw, BF; Quigley, MA; White, KL	1
Kolbeck, RC; Speir, WA	1
Christopher, MA; Harman, E; Hendeles, L	1
Asai, KI; Kuzuya, F; Naito, M; Shibata, K	1
Gudenzi, M; Mustafa, SJ; Nakagawa, Y	1
Abernethy, DR; Carrum, G; Dickinson, TH; Egan, JM	1
Esau, SA	1
Lalonde, RL; Pieper, JA; Self, TH; Sirmans, SM; Smith, DG	1
Bertino, JS; May, JJ; Nafziger, AN	1
Weishaar, RE	1
Kudoh, S; Satoh, A	1
Ebihara, A; Fujimura, A; Ohashi, K; Sakamoto, K; Shiga, T; Sudo, T; Tateishi, T	1
Ashraf, G; Javed, MH; Saeed, SA	1
Alsar, MJ; Sacristan, JA; Soto, J	1
Alleva, FR; Balazs, T; Joseph, X; Vick, JA; Whitehurst, VE; Zhang, J	1
Arakawa, K; Hayashi, K; Ichihara, A; Kubota, E; Matsuda, H; Matsumoto, A; Naitoh, M; Saruta, T; Suzuki, H	1
Fassihi, R; Kim, H	1
Bodmeier, R; Lecomte, F; Siepmann, J	1
Cheng, K; Song, X; Sun, L; Zhang, J; Zhu, J	1
Fassihi, R; Pillay, V	1
Hayashi, Y; Inoue, K; Iwao, T; Watanabe, J; Yuasa, H	1
Chanda, E; Datta, BK; Haider, SS; Quadir, MA; Reza, MD	1
Krejcová, K; Polásek, E; Prokopová, A; Rabisková, M; Tomásek, V; Vetchý, D	1
Alvarez-Manceñido, F; Lacik, I; Landin, M; Martínez-Pacheco, R	1
Cheboyina, S; Wyandt, CM	2
Carlin, B; Leclercq, B; Muschert, S; Siepmann, F; Siepmann, J	2
Fassihi, R; Liu, Q	1
Ferrero, C; Jiménez-Castellanos, MR; Marinich, JA	1
Chiang, W; Li, ML; Lin, JH; Liu, YT; Yao, HT	1
Descamps, N; Elgaied-Lamouchi, D; Lefèvre, P; Mackin-Mohamour, AR; Muschert, S; Neut, C; Siepmann, F; Siepmann, J	1

Reviews

2 review(s) available for diltiazem and theophylline

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Interpretation and application of world-wide safety data on diltiazem. Acta pharmacologica et toxicologica, 1985, Volume: 57 Suppl 2 Topics: Adrenergic beta-Antagonists; Benzazepines; Clinical Trials as Topic; Diltiazem; Drug Interactions; Heart Conduction System; Humans; Myocardial Contraction; Product Surveillance, Postmarketing; Theophylline	1985

Trials

5 trial(s) available for diltiazem and theophylline

Article	Year
[Asthma of physical effort and the effect of nifedipine and diltiazem]. Terapevticheskii arkhiv, 1991, Volume: 63, Issue:8 Topics: Adult; Asthma, Exercise-Induced; Diltiazem; Female; Humans; Male; Nifedipine; Respiratory Function Tests; Theophylline; Time Factors	1991
The influence of nifedipine and diltiazem on serum theophylline concentration-time profiles. Journal of clinical pharmacy and therapeutics, 1989, Volume: 14, Issue:5 Topics: Adult; Diltiazem; Drug Interactions; Female; Humans; Male; Nifedipine; Random Allocation; Single-Blind Method; Theophylline	1989
Interpretation and application of world-wide safety data on diltiazem. Acta pharmacologica et toxicologica, 1985, Volume: 57 Suppl 2 Topics: Adrenergic beta-Antagonists; Benzazepines; Clinical Trials as Topic; Diltiazem; Drug Interactions; Heart Conduction System; Humans; Myocardial Contraction; Product Surveillance, Postmarketing; Theophylline	1985
Effect of calcium channel blockers on theophylline disposition. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:1 Topics: Adult; Calcium Channel Blockers; Data Interpretation, Statistical; Diltiazem; Half-Life; Humans; Male; Nifedipine; Random Allocation; Theophylline; Verapamil	1988
Effects of diltiazem and cimetidine on theophylline oxidative metabolism. Journal of clinical pharmacology, 1993, Volume: 33, Issue:12 Topics: Adult; Biotransformation; Cimetidine; Depression, Chemical; Diltiazem; Half-Life; Humans; Male; Oxidation-Reduction; Theophylline	1993

Other Studies

63 other study(ies) available for diltiazem and theophylline

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. Journal of medicinal chemistry, 1998, Mar-26, Volume: 41, Issue:7 Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet	1998
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Effect of diltiazem on insulin secretion. I. Experiments in vitro. Japanese journal of pharmacology, 1977, Volume: 27, Issue:5 Topics: Animals; Benzazepines; Calcium; Calcium Chloride; Cyclic AMP; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Stimulation, Chemical; Theophylline	1977
Effects of prostaglandin E1 on isolated dog renal artery. Urology, 1979, Volume: 14, Issue:6 Topics: Animals; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Papaverine; Phenoxybenzamine; Phentolamine; Potassium; Propranolol; Prostaglandin Antagonists; Prostaglandins E; Renal Artery; Theophylline	1979
Effect of amphotericin B on intracellular calcium levels in cultured glomerular mesangial cells. European journal of pharmacology, 1992, May-12, Volume: 226, Issue:1 Topics: Amphotericin B; Calcium; Cells, Cultured; Culture Media; Diltiazem; Fura-2; Glomerular Mesangium; Meglumine; Sodium; Theophylline	1992
Mechanisms of amphotericin B-induced decrease in glomerular filtration rate in rats. Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:12 Topics: Amphotericin B; Animals; Bucladesine; Creatinine; Diltiazem; Drug Interactions; Glomerular Filtration Rate; Infusions, Intra-Arterial; Male; Rats; Rats, Inbred Strains; Renal Circulation; Sodium Chloride; Theophylline	1991
Stimulation of acetylcholine release in myenteric plexus by calcitonin gene-related peptide. The American journal of physiology, 1990, Volume: 259, Issue:6 Pt 1 Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Cells, Cultured; Colforsin; Dideoxyadenosine; Diltiazem; Guinea Pigs; Kinetics; Male; Myenteric Plexus; Neurons; Organ Culture Techniques; Sincalide; Substance P; Theophylline	1990
Doxofylline differs from methylxanthines in its movement of cytosolic calcium. International journal of tissue reactions, 1991, Volume: 13, Issue:3 Topics: Aminophylline; Animals; Binding Sites; Blood Platelets; Calcium; Cytosol; Diltiazem; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Theophylline; Verapamil	1991
A role for adenosine calcium and ischemia in radiocontrast-induced intrarenal vasoconstriction. American journal of nephrology, 1990, Volume: 10, Issue:4 Topics: Acute Kidney Injury; Adenosine; Animals; Biological Transport, Active; Calcium; Contrast Media; Diatrizoate Meglumine; Diltiazem; Dogs; Female; Ischemia; Male; Renal Circulation; Sodium; Theophylline; Vasoconstriction; Verapamil	1990
Vascular endothelial cell migration in vitro roles of cyclic nucleotides, calcium ion and cytoskeletal system. Artery, 1989, Volume: 17, Issue:1 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta, Thoracic; Bucladesine; Calcium Channel Blockers; Cattle; Cell Movement; Cells, Cultured; Colchicine; Cytochalasin B; Diltiazem; Endothelium, Vascular; Fetus; Gallic Acid; Nicardipine; Sulfonamides; Theophylline; Trifluoperazine	1989
Role of acetylcholine in induction of repetitive activity in human atrial fibers. The American journal of physiology, 1989, Volume: 256, Issue:1 Pt 2 Topics: Acetylcholine; Action Potentials; Adolescent; Adult; Aged; Atrial Function; Atropine; Child; Child, Preschool; Diltiazem; Drug Synergism; Epinephrine; Female; Heart; Heart Atria; Humans; In Vitro Techniques; Infant; Male; Methacholine Chloride; Methacholine Compounds; Middle Aged; Theophylline	1989
Role of theophylline, verapamil, and diltiazem on rat fatigued diaphragmatic muscle in vitro. Proceedings of the Western Pharmacology Society, 1989, Volume: 32 Topics: Animals; Diaphragm; Diltiazem; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Respiratory Muscles; Theophylline; Verapamil	1989
Attenuation of rifampicin-induced theophylline metabolism by diltiazem/rifampicin coadministration in healthy volunteers. European journal of clinical pharmacology, 1989, Volume: 37, Issue:2 Topics: Adult; Diltiazem; Half-Life; Humans; Male; Rifampin; Theophylline	1989
Diltiazem, verapamil, and nifedipine inhibit theophylline-enhanced diaphragmatic contractility. The American review of respiratory disease, 1989, Volume: 139, Issue:1 Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Diaphragm; Diltiazem; Male; Muscle Contraction; Nifedipine; Rats; Rats, Inbred Strains; Theophylline; Verapamil	1989
Clinical relevance of the interaction of theophylline with diltiazem or nifedipine. Chest, 1989, Volume: 95, Issue:2 Topics: Adolescent; Adult; Asthma; Diltiazem; Drug Interactions; Drug Therapy, Combination; Humans; Nifedipine; Theophylline	1989
Influences of Ca2+: antagonist and cyclic AMP on vascular smooth muscle cells in culture. Angiology, 1985, Volume: 36, Issue:9 Topics: Animals; Aorta; Benzazepines; Bucladesine; Calcium; Cattle; Cell Division; Cells, Cultured; Cyclic AMP; Diltiazem; Edetic Acid; Muscle, Smooth, Vascular; Theophylline	1985
Calcium entry blocking activity of dilazep in dog coronary artery. Pharmacology, 1986, Volume: 33, Issue:3 Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Arteries; Azepines; Calcium; Calcium Channel Blockers; Coronary Vessels; Dilazep; Diltiazem; Dipyridamole; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Lidoflazine; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Receptors, Cell Surface; Receptors, Purinergic; Theophylline	1986
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3 Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline; Verapamil	1988
Interaction of theophylline, verapamil, and diltiazem on hamster diaphragm muscle force in vitro. The American journal of physiology, 1988, Volume: 254, Issue:3 Pt 1 Topics: Animals; Calcium; Cricetinae; Diaphragm; Diltiazem; Drug Interactions; In Vitro Techniques; Mesocricetus; Muscles; Theophylline; Verapamil	1988
Inhibition of theophylline elimination by diltiazem therapy. Journal of clinical pharmacology, 1987, Volume: 27, Issue:11 Topics: Adult; Aminophylline; Diltiazem; Drug Interactions; Humans; Injections, Intravenous; Male; Middle Aged; Smoking; Theophylline	1987
"Calcium antagonists" and "calcium agonists": is there a place in pharmacology for these two misnomers? Life sciences, 1984, Jul-30, Volume: 35, Issue:5 Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Humans; Indenes; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardium; Ouabain; Theophylline	1984
[Basic studies on the prevention of cyclosporin A induced nephrotoxicity]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1994, Volume: 85, Issue:5 Topics: Animals; Cyclosporine; Diltiazem; Humans; Kidney; Kidney Diseases; Lymphocyte Activation; Male; Rats; Rats, Wistar; Theophylline	1994
Modulation of cyclic AMP-dependent protein kinase activity by drugs affecting human platelet aggregation. Biochemical Society transactions, 1993, Volume: 21, Issue:4 Topics: Aspirin; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Diltiazem; Humans; Kinetics; Masoprocol; Platelet Aggregation; Theophylline; Verapamil	1993
Diltiazem treatment impairs theophylline elimination in patients with bronchospastic airway disease. Therapeutic drug monitoring, 1994, Volume: 16, Issue:1 Topics: Aged; Bronchial Spasm; Diltiazem; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged; Theophylline	1994
Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats. Toxicology, 1996, Jun-17, Volume: 110, Issue:1-3 Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Death, Sudden, Cardiac; Diltiazem; Disease Models, Animal; Dogs; Electrocardiography; Female; Heart Rate; Hypotension; Infusions, Intravenous; Injections, Intraperitoneal; Male; Nifedipine; Phosphodiesterase Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Respiration; Theophylline; Verapamil	1996
Role of adenosine in the renal responses to contrast medium. Kidney international, 1996, Volume: 49, Issue:5 Topics: Adenosine; Animals; Calcium Channel Blockers; Contrast Media; Diltiazem; Dogs; Glomerular Filtration Rate; Humans; Iohexol; Kidney; Kidney Failure, Chronic; Male; Nephrectomy; Radiography; Receptors, Purinergic P1; Renal Circulation; Renal Plasma Flow, Effective; Theophylline; Vasoconstriction; Vasodilation	1996
Application of binary polymer system in drug release rate modulation. 2. Influence of formulation variables and hydrodynamic conditions on release kinetics. Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:3 Topics: Delayed-Action Preparations; Diltiazem; Kinetics; Lactose; Methylcellulose; Molecular Weight; Nifedipine; Oxazines; Pectins; Prednisolone; Pressure; Solubility; Tablets; Theophylline	1997
Diffusion-controlled drug delivery systems: calculation of the required composition to achieve desired release profiles. Journal of controlled release : official journal of the Controlled Release Society, 1999, Aug-05, Volume: 60, Issue:2-3 Topics: Cellulose; Diffusion; Diltiazem; Drug Delivery Systems; In Vitro Techniques; Models, Biological; Plasticizers; Polymers; Theophylline; Time Factors; Vasodilator Agents	1999
Studies of hydroxypropyl methylcellulose donut-shaped tablets. Drug development and industrial pharmacy, 1999, Volume: 25, Issue:9 Topics: Diltiazem; Lactose; Methylcellulose; Oxazines; Solubility; Tablets; Theophylline; Time Factors	1999
In situ electrolyte interactions in a disk-compressed configuration system for up-curving and constant drug delivery. Journal of controlled release : official journal of the Controlled Release Society, 2000, Jun-15, Volume: 67, Issue:1 Topics: Diltiazem; Drug Delivery Systems; Electrolytes; Hydrogen-Ion Concentration; Hypromellose Derivatives; Kinetics; Methylcellulose; Molecular Weight; Polyethylene Glycols; Solubility; Tablets, Enteric-Coated; Theophylline	2000
Absorption and metabolic extraction of diltiazem from the perfused rat small intestine. Drug metabolism and pharmacokinetics, 2004, Volume: 19, Issue:6 Topics: Absorption; Algorithms; Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; In Vitro Techniques; Intestinal Absorption; Intestine, Small; Male; Perfusion; Rats; Rats, Wistar; Theophylline; Vasodilator Agents	2004
Evaluation of ethylcellulose as matrices for controlled release drug delivery. Pakistan journal of pharmaceutical sciences, 2005, Volume: 18, Issue:2 Topics: Cellulose; Compressive Strength; Delayed-Action Preparations; Diclofenac; Diltiazem; Drug Carriers; Hydrogen-Ion Concentration; Kinetics; Solubility; Tablets; Technology, Pharmaceutical; Theophylline; Time Factors	2005
The influence of drug solubility and particle size on the pellet formulation in a rotoprocessor. Drug development and industrial pharmacy, 2006, Volume: 32, Issue:5 Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Bronchodilator Agents; Calcium Channel Blockers; Cellulose; Chemistry, Pharmaceutical; Diclofenac; Diltiazem; Drug Compounding; Excipients; Lactase; Particle Size; Solubility; Theophylline; Water	2006
Konjac glucomannan and konjac glucomannan/xanthan gum mixtures as excipients for controlled drug delivery systems. Diffusion of small drugs. International journal of pharmaceutics, 2008, Feb-12, Volume: 349, Issue:1-2 Topics: Amorphophallus; Calcium Channel Blockers; Chemistry, Pharmaceutical; Chromatography, Gel; Delayed-Action Preparations; Diffusion; Diltiazem; Drug Delivery Systems; Excipients; Mannans; Molecular Weight; Pharmaceutical Preparations; Phosphodiesterase Inhibitors; Polysaccharides, Bacterial; Rheology; Spectroscopy, Fourier Transform Infrared; Temperature; Theophylline; Viscosity	2008
Wax-based sustained release matrix pellets prepared by a novel freeze pelletization technique II. In vitro drug release studies and release mechanisms. International journal of pharmaceutics, 2008, Jul-09, Volume: 359, Issue:1-2 Topics: Cetomacrogol; Chemistry, Pharmaceutical; Crystallization; Delayed-Action Preparations; Diffusion; Diglycerides; Diltiazem; Freezing; Glycerides; Hydrophobic and Hydrophilic Interactions; Kinetics; Microscopy, Electron, Scanning; Solubility; Theophylline; Waxes	2008
Wax-based sustained release matrix pellets prepared by a novel freeze pelletization technique I. Formulation and process variables affecting pellet characteristics. International journal of pharmaceutics, 2008, Jul-09, Volume: 359, Issue:1-2 Topics: Chemistry, Pharmaceutical; Colloids; Crystallization; Delayed-Action Preparations; Diltiazem; Drug Stability; Freezing; Glycerol; Particle Size; Silica Gel; Silicon Dioxide; Solubility; Surface-Active Agents; Theophylline; Waxes	2008
Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2009, Volume: 72, Issue:1 Topics: Acetaminophen; Cellulose; Chemistry, Pharmaceutical; Diltiazem; Drug Carriers; Drug Delivery Systems; Metoprolol; Polyethylene Glycols; Polymers; Polyvinyl Alcohol; Tablets, Enteric-Coated; Technology, Pharmaceutical; Temperature; Theophylline	2009
Application of a novel symmetrical shape factor to gastroretentive matrices as a measure of swelling synchronization and its impact on drug release kinetics under standard and modified dissolution conditions. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:7 Topics: Delayed-Action Preparations; Diltiazem; Drug Carriers; Excipients; Hypromellose Derivatives; Kinetics; Methylcellulose; Polyethylene Glycols; Povidone; Quinazolines; Solubility; Tablets; Technology, Pharmaceutical; Theophylline	2009
Simulated food effects on drug release from ethylcellulose: PVA-PEG graft copolymer-coated pellets. Drug development and industrial pharmacy, 2010, Volume: 36, Issue:2 Topics: Cellulose; Chemistry, Pharmaceutical; Diltiazem; Drug Carriers; Food; Polyvinyls; Tablets, Enteric-Coated; Theophylline	2010
Graft copolymers of ethyl methacrylate on waxy maize starch derivatives as novel excipients for matrix tablets: drug release and fronts movement kinetics. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 80, Issue:3 Topics: Carbohydrates; Chemistry, Pharmaceutical; Diffusion; Diltiazem; Drug Compounding; Excipients; Kinetics; Methylmethacrylates; Models, Theoretical; Polymers; Porosity; Solubility; Starch; Tablets; Technology, Pharmaceutical; Theophylline; Zea mays	2012
Food-Drug Interaction between the Adlay Bran Oil and Drugs in Rats. Nutrients, 2019, Oct-15, Volume: 11, Issue:10 Topics: Administration, Intravenous; Administration, Oral; Animals; Capsaicin; Chlorzoxazone; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Diltiazem; Food-Drug Interactions; Intestinal Absorption; Intestines; Liver; Male; Plant Oils; Rats, Sprague-Dawley; Risk Assessment; Theophylline	2019
Robustness of Controlled Release Tablets Based on a Cross-linked Pregelatinized Potato Starch Matrix. AAPS PharmSciTech, 2020, May-20, Volume: 21, Issue:5 Topics: Delayed-Action Preparations; Diltiazem; Drug Liberation; Gelatin; Humans; Hypromellose Derivatives; Solanum tuberosum; Starch; Tablets; Theophylline	2020