Page last updated: 2024-08-23

diltiazem and tacrolimus

diltiazem has been researched along with tacrolimus in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (21.95)	18.2507
2000's	15 (36.59)	29.6817
2010's	13 (31.71)	24.3611
2020's	4 (9.76)	2.80

Authors

Authors	Studies
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bauer, S; Brockmöller, J; Kewitz, H; Roots, I	1
Endo, T; Koshiba, K; Kumano, K	1
Endo, T; Kumano, K; Kuwao, S; Wang, G	1
Alessiani, M; Iacona, I; Molinaro, M; Regazzi, MB; Spada, M; Vaccarisi, S; Villani, P	1
Baltes, A; Becker, G; Hamar, P; Heemann, U; Philipp, T; Witzke, O	1
Demetris, AJ; Gritsch, A; Jordan, M; Katari, SR; Magnone, M; McCauley, J; Randhawa, PS; Scantlebury, V; Shapiro, R; Starzl, T; Vivas, C	1
Finney, NS	1
Ito, K; Suzuki, T; Tada, H; Yanagiwara, S	1
Hebert, MF; Lam, AY	1
Chen, JC; Ma, P	1
Jones, TE; Morris, RG	1
Dietl, KH	1
Bhaloo, S; Prasad, GV	1
Bayle, F; Bessard, G; Contamin, C; Hardy, G; Serre-Debeauvais, F; Stanke-Labesque, F; Zaoui, P	1
Kothari, J; Nash, M; Ramesh Prasad, GV; Zaltzman, J	1
Balasubramaniam, R; Chawla, S; Grace, AA; Huang, CL	1
Akhlaghi, F; Gleeson, M; McCaughan, G; McLachlan, AJ; Nelson, A; Zahir, H	1
Chen, LQ; Chen, LZ; Chen, YH; Hu, JB; Li, WL; Liang, JJ; Liang, YX; Qiu, J; Xie, KJ; Zhang, J; Zheng, KL; Zhong, WD	1
Fu, Q; Huang, M; Li, JL; Liu, LS; Wang, CX; Wang, XD; Zhou, SF	1
Chen, LQ; Chen, LZ; Chen, YH; Hu, JB; Liang, JJ; Liang, YX; Lu, YM; Qiu, J; Wang, B; Xie, KJ; Zhang, J; Zheng, KL; Zhong, WD	1
Chen, SY; Chen, X; Fu, Q; Huang, M; Li, JL; Liu, LS; Teng, LC; Wang, CX; Wang, XD	1
Arase, S; Fukumoto, D; Hida, Y; Ishigami, T; Kubo, Y	1
Gitman, M; Hazzan, A; Jhaveri, KD; Patni, H	1
Houjo, T; Ishigai, M; Kato, M; Ogawa, K	1
Chan, TM; Kwan, LP; Ma, MK; Mok, MM; Tang, CS; Yap, DY	1
Ding, JJ; Guan, XF; Li, DY; Ma, RR; Wang, JL; Yin, WJ; Zhou, LY; Zuo, XC	1
Chen, F; Ding, XS; Guo, HL; Hu, YH; Jing, X; Sun, F; Sun, JY; Xu, J; Xu, ZJ	1
Chen, L; Chen, Y; Lei, W; Li, M; Liang, J; Lin, Y; Lu, Y; Yang, J; Zhang, J; Zhang, Z	1
Ko, CJ; Siegel, JD	1
Hiremath, J; Lodha, AR; Pillai, A; Sheth, K	1
Bacon, S; Croker, R; Curtis, HJ; Goldacre, B; MacKenna, B; Walker, AJ	1
Kunlamas, Y; Susomboon, T; Vadcharavivad, S; Vongwiwatana, A	1

Reviews

3 review(s) available for diltiazem and tacrolimus

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Enantioselective epoxide hydrolysis: catalysis involving microbes, mammals and metals. Chemistry & biology, 1998, Volume: 5, Issue:4 Topics: Antibodies, Catalytic; Antihypertensive Agents; Antineoplastic Agents; Catalysis; Diltiazem; Epothilones; Epoxy Compounds; Hydrolysis; Immunosuppressive Agents; Tacrolimus; Thiazoles	1998
Diltiazem-associated photodistributed hyperpigmentation: report of two Japanese cases and published work review. The Journal of dermatology, 2010, Volume: 37, Issue:9 Topics: Aged, 80 and over; Asian People; Calcium Channel Blockers; Diltiazem; Drug Eruptions; Female; Humans; Hyperpigmentation; Japan; Photosensitivity Disorders; Tacrolimus; Treatment Outcome	2010

Trials

6 trial(s) available for diltiazem and tacrolimus

Article	Year
Oral dosing of tacrolimus and cyclosporine microemulsion--results from a large multicenter study in renal transplantation. Transplantation proceedings, 2002, Volume: 34, Issue:5 Topics: Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emulsions; Europe; Female; Humans; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Survival Analysis; Tacrolimus	2002
Population pharmacokinetic estimation of tacrolimus apparent clearance in adult liver transplant recipients. Therapeutic drug monitoring, 2005, Volume: 27, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aged; Algorithms; Diltiazem; Dose-Response Relationship, Drug; Drug Monitoring; Female; Fluconazole; Humans; Immunosuppressive Agents; Liver Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Prednisolone; Retrospective Studies; Tacrolimus	2005
Effects of diltiazem on pharmacokinetics of tacrolimus in relation to CYP3A5 genotype status in renal recipients: from retrospective to prospective. The pharmacogenomics journal, 2011, Volume: 11, Issue:4 Topics: Adolescent; Adult; Algorithms; Calcium Channel Blockers; Chi-Square Distribution; China; Cytochrome P-450 CYP3A; Diltiazem; Drug Dosage Calculations; Drug Interactions; Female; Genotype; Humans; Immunosuppressive Agents; Kidney Transplantation; Linear Models; Male; Middle Aged; Pharmacogenetics; Phenotype; Prospective Studies; Retrospective Studies; Tacrolimus; Young Adult	2011
Significant reduction of Tacrolimus trough level after conversion from twice daily Prograf to once daily Advagraf in Chinese renal transplant recipients with or without concomitant diltiazem treatment. Renal failure, 2013, Volume: 35, Issue:7 Topics: Adult; Antihypertensive Agents; Chi-Square Distribution; China; Delayed-Action Preparations; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Prospective Studies; Tacrolimus; Treatment Outcome	2013
Population Pharmacokinetic Modeling of Diltiazem in Chinese Renal Transplant Recipients. European journal of drug metabolism and pharmacokinetics, 2018, Volume: 43, Issue:1 Topics: Adolescent; Adult; Antihypertensive Agents; Asian People; ATP Binding Cassette Transporter, Subfamily B; Cytochrome P-450 CYP3A; Diltiazem; Female; Genotype; Humans; Kidney Transplantation; Male; Middle Aged; Models, Biological; Polymorphism, Restriction Fragment Length; Tacrolimus; Young Adult	2018
The effect of the very low dosage diltiazem on tacrolimus exposure very early after kidney transplantation: a randomized controlled trial. Scientific reports, 2022, 08-21, Volume: 12, Issue:1 Topics: Cytochrome P-450 CYP3A; Diltiazem; Genotype; Immunosuppressive Agents; Kidney Transplantation; Tacrolimus	2022

Other Studies

32 other study(ies) available for diltiazem and tacrolimus

Article	Year
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The effect of the new immunosuppressive drug FK506 on the formation of secondary metabolites of cyclosporin A. International journal of clinical pharmacology, therapy, and toxicology, 1992, Volume: 30, Issue:11 Topics: Biotransformation; Cyclosporine; Diltiazem; Erythromycin; Humans; Immunosuppressive Agents; In Vitro Techniques; Microsomes, Liver; Tacrolimus	1992
[Functional and morphological changes in rat kidney induced by FK506 and its reversal by various vasodilators]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1992, Volume: 83, Issue:5 Topics: Animals; Calcium; Captopril; Diltiazem; Hemodynamics; Kidney; Male; Necrosis; Prazosin; Rats; Rats, Inbred Strains; Tacrolimus	1992
FK 506-induced nephrotoxicity in rats. Transplantation proceedings, 1991, Volume: 23, Issue:1 Pt 1 Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Captopril; Diltiazem; Glomerular Filtration Rate; Immunosuppressive Agents; Kidney; Male; Organ Size; Prazosin; Rats; Rats, Inbred Strains; Reference Values; Renal Circulation; Tacrolimus; Vascular Resistance	1991
Interaction between FK 506 and diltiazem in an animal model. Transplantation proceedings, 1996, Volume: 28, Issue:2 Topics: Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Immunosuppressive Agents; Infusions, Intravenous; Swine; Tacrolimus	1996
Diltiazem minimizes tubular damage due to FK506-mediated nephrotoxicity following ischemia and reperfusion in rats. Transplant immunology, 1996, Volume: 4, Issue:1 Topics: Acetylglucosaminidase; Animals; Creatinine; Diltiazem; Ischemia; Kidney Tubules; Male; Rats; Rats, Sprague-Dawley; Reperfusion; Tacrolimus	1996
Clinical features of acute reversible tacrolimus (FK 506) nephrotoxicity in kidney transplant recipients. Clinical transplantation, 1997, Volume: 11, Issue:3 Topics: Acute Disease; Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Antifungal Agents; Biopsy, Needle; Clarithromycin; Creatinine; Diltiazem; Drug Interactions; Female; Humans; Hyperglycemia; Hyperkalemia; Hypertension; Immunosuppressive Agents; Infusions, Intravenous; Itraconazole; Kidney; Kidney Transplantation; Male; Middle Aged; Tacrolimus; Time Factors; Transplantation, Homologous; Tremor; Ultrasonography; Vasodilator Agents	1997
Role of diltiazem on tacrolimus pharmacokinetics in tacrolimus-induced nephrotoxic rats. Pharmacology & toxicology, 1999, Volume: 84, Issue:6 Topics: Animals; Calcium Channel Blockers; Diltiazem; Immunosuppressive Agents; Kidney; Kidney Cortex; Kidney Diseases; Kidney Function Tests; Kidney Medulla; Male; Rats; Rats, Sprague-Dawley; Tacrolimus; Tissue Distribution	1999
Diltiazem increases tacrolimus concentrations. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:6 Topics: Aged; Calcium Channel Blockers; Diltiazem; Drug Interactions; Graft Rejection; Humans; Immunosuppressive Agents; Infusions, Intravenous; Liver Transplantation; Male; Psychoses, Substance-Induced; Tacrolimus	1999
Mechanism of FK506-induced renal hypoperfusion and its reversion in rats. Acta pharmacologica Sinica, 2001, Volume: 22, Issue:11 Topics: Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Endothelins; Glomerular Filtration Rate; Immunosuppressive Agents; Kidney; Kidney Diseases; Male; Perfusion; Rats; Rats, Sprague-Dawley; Tacrolimus; Urination	2001
Pharmacokinetic interaction between tacrolimus and diltiazem: dose-response relationship in kidney and liver transplant recipients. Clinical pharmacokinetics, 2002, Volume: 41, Issue:5 Topics: Area Under Curve; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Liver Transplantation; Male; Middle Aged; Tacrolimus	2002
Severe reduction in tacrolimus levels with rifampin despite multiple cytochrome P450 inhibitors: a case report. Transplantation proceedings, 2003, Volume: 35, Issue:7 Topics: Adult; Clarithromycin; Creatinine; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Drug Therapy, Combination; Female; Fluconazole; Humans; Immunosuppressive Agents; Kidney Function Tests; Kidney Transplantation; Rifampin; Tacrolimus	2003
Protease inhibitors and diltiazem increase tacrolimus blood concentration in a patient with renal transplantation: a case report. European journal of clinical pharmacology, 2004, Volume: 60, Issue:8 Topics: Adult; Antihypertensive Agents; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Diagnosis, Differential; Diltiazem; Drug Interactions; HIV Infections; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Protease Inhibitors; Tacrolimus	2004
Diltiazem use in tacrolimus-treated renal transplant recipients. Journal of clinical pharmacy and therapeutics, 2004, Volume: 29, Issue:5 Topics: Adult; Blood Pressure; Calcium Channel Blockers; Diltiazem; Female; Health Care Costs; Humans; Hypertension; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Retrospective Studies; Tacrolimus	2004
Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:4 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Cytosol; Diltiazem; Electric Stimulation; Homeostasis; Immunosuppressive Agents; In Vitro Techniques; Mice; Mice, Inbred Strains; Myocytes, Cardiac; Nifedipine; Perfusion; Phosphodiesterase Inhibitors; Ryanodine Receptor Calcium Release Channel; Tachycardia, Ventricular; Tacrolimus	2005
[Prevention of diltiazem in tacrolimus-induced nephrotoxicity: experiment with rats]. Zhonghua yi xue za zhi, 2007, Aug-28, Volume: 87, Issue:32 Topics: Animals; Creatine; Cyclosporine; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Kidney Transplantation; Male; Postoperative Period; Random Allocation; Rats; Rats, Sprague-Dawley; Tacrolimus	2007
Rapid and simultaneous determination of tacrolimus (FK506) and diltiazem in human whole blood by liquid chromatography-tandem mass spectrometry: application to a clinical drug-drug interaction study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, May-01, Volume: 867, Issue:1 Topics: Chromatography, High Pressure Liquid; Diltiazem; Drug Interactions; Humans; Immunosuppressive Agents; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tacrolimus; Tandem Mass Spectrometry	2008
[Nephrotoxicity of tacrolimus and preventive effect of diltiazem: experiment with rats]. Zhonghua yi xue za zhi, 2009, Mar-17, Volume: 89, Issue:10 Topics: Animals; Diltiazem; Kidney; Kidney Transplantation; Male; Rats; Rats, Sprague-Dawley; Tacrolimus	2009
Ranolazine, tacrolimus, and diltiazem might be a hazardous combination in a transplant patient. Renal failure, 2012, Volume: 34, Issue:2 Topics: Acetanilides; Acute Kidney Injury; Calcium Channel Blockers; Diltiazem; Drug Interactions; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Piperazines; Postoperative Complications; Ranolazine; Tacrolimus	2012
A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:5 Topics: Alprazolam; Animals; Cytochrome P-450 CYP3A; Diltiazem; Humans; Liver; Macaca fascicularis; Midazolam; Tacrolimus	2013
Diltiazem used as a tacrolimus-sparing agent for treatment of pediatric patients with refractory nephrotic syndrome: a case report and retrospective analysis. European journal of clinical pharmacology, 2019, Volume: 75, Issue:4 Topics: Child; Child, Preschool; Cytochrome P-450 CYP3A; Diltiazem; Drug Interactions; Drug Resistance; Female; Glucocorticoids; Humans; Immunosuppressive Agents; Male; Nephrotic Syndrome; Retrospective Studies; Tacrolimus; Treatment Outcome	2019
Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats. Andrologia, 2019, Volume: 51, Issue:5 Topics: Animals; Calcineurin Inhibitors; Calcium Channel Blockers; Cyclosporine; Diltiazem; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Gonadal Steroid Hormones; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Microscopy, Electron, Transmission; Nephrectomy; Rats; Rats, Sprague-Dawley; Semen Analysis; Sperm Motility; Tacrolimus; Testis	2019
Diltiazem-associated Photodistributed Hyperpigmentation. The Yale journal of biology and medicine, 2020, Volume: 93, Issue:1 Topics: Aged; Biopsy; Calcium Channel Blockers; Dermatologic Agents; Diltiazem; Female; Humans; Hyperpigmentation; Hypertension; Ointments; Photosensitivity Disorders; Skin; Tacrolimus; Treatment Outcome; Withholding Treatment	2020
A retrospective cohort study exploring diltiazem as a pharmaco-enhancer for tacrolimus, in a post-heart transplant setting. Clinical transplantation, 2020, Volume: 34, Issue:12 Topics: Diltiazem; Heart Transplantation; Humans; Immunosuppressive Agents; Kidney Transplantation; Retrospective Studies; Tacrolimus	2020
Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care. Journal of medical Internet research, 2020, 10-16, Volume: 22, Issue:10 Topics: Cohort Studies; Cyclosporine; Diltiazem; Electronic Health Records; England; Female; Humans; Inappropriate Prescribing; Male; Primary Health Care; Retrospective Studies; Tacrolimus	2020