Page last updated: 2024-08-23

diltiazem and simvastatin

diltiazem has been researched along with simvastatin in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (8.33)	18.2507
2000's	21 (58.33)	29.6817
2010's	11 (30.56)	24.3611
2020's	1 (2.78)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Buja, LM; Casscells, SW; Goff, DC; Gould, KL	1
Eatman, D; Rutecki, GW; Stallone, JN; Whittier, FC	1
Ramsay, LE; Wallis, EJ; Yeo, KR; Yeo, WW	1
Brater, DC; Hall, SD; Mousa, O; Sunblad, KJ	1
Alvarez de Sotomayor, M; Herrera, MD; Marhuenda, E; Pérez-Guerrero, C	1
Yeo, KR; Yeo, WW	1
Bortolini, M	1
Peces, R; Pobes, A	1
Byrd, RP; Fields, CL; Kanathur, N; Mathai, MG; Roy, TM	1
Bottorff, M; Worz, CR	1
Hayashi, H; Ishizaki, T; Kosuge, K; Nishio, S; Ohashi, K; Satoh, H; Uchida, S; Watanabe, H; Yamada, H	1
Abdallah, H; Chu, N; Huan, BL; Hussein, Z; Jerling, M; Leung, K	1
Alvarez de Sotomayor, M; Herrera, MD; Marhuenda, E; Márquez-Martín, A; Pérez-Guerrero, C	1
Molden, E; Westergren, T	1
Ang, PS; Su, DH; Tow, SL	1
Rifkin, SI	1
Larsen, W; Mandleco, B	1
Chan, WK; Chung, PF; Hu, M; Tomlinson, B; You, JH	1
Eckel, RH	1
Hu, M; Mak, VW; Tomlinson, B	1
Choi, DH; Choi, JS; Li, C	1
Bellingan, G; Shulman, R; Singer, M; Thakrar, R	1
Ainsworth, M; Bookstaver, D; Gleaton, M; Milner, E	1

Reviews

3 review(s) available for diltiazem and simvastatin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The role of cytochrome P450-mediated drug-drug interactions in determining the safety of statins. Expert opinion on pharmacotherapy, 2001, Volume: 2, Issue:7 Topics: Aged; Clinical Trials as Topic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Drug Interactions; Enzyme Inhibitors; Female; Guidelines as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Isoenzymes; Itraconazole; Lovastatin; Male; Middle Aged; Muscular Diseases; Pravastatin; Rhabdomyolysis; Simvastatin	2001
[Interaction risk with statin switch]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2007, Feb-15, Volume: 127, Issue:4 Topics: Anticholesteremic Agents; Anticoagulants; Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Atorvastatin; Diltiazem; Drug Interactions; Drug Therapy, Combination; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Hemorrhages; Muscular Diseases; Pyrroles; Risk Factors; Simvastatin; Warfarin	2007

Trials

4 trial(s) available for diltiazem and simvastatin

Article	Year
The interaction of diltiazem with simvastatin. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adult; Cardiovascular Agents; Diltiazem; Drug Administration Schedule; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Reference Values; Simvastatin	2000
Pharmacokinetic and pharmacodynamic interactions between simvastatin and diltiazem in patients with hypercholesterolemia and hypertension. Life sciences, 2004, Dec-03, Volume: 76, Issue:3 Topics: Administration, Oral; Area Under Curve; Blood Pressure; Calcium Channel Blockers; Diltiazem; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Lipids; Liver Function Tests; Male; Middle Aged; Simvastatin; Treatment Outcome	2004
Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects. Journal of clinical pharmacology, 2005, Volume: 45, Issue:4 Topics: Acetanilides; Adolescent; Adult; Diltiazem; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Humans; Ketoconazole; Male; Middle Aged; Piperazines; Ranolazine; Simvastatin	2005
Effects of concomitant therapy with diltiazem on the lipid responses to simvastatin in Chinese subjects. Journal of clinical pharmacology, 2010, Volume: 50, Issue:10 Topics: Antihypertensive Agents; Area Under Curve; Asian People; Cholesterol, LDL; Cross-Over Studies; Diltiazem; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Male; Middle Aged; Prospective Studies; Simvastatin	2010

Other Studies

29 other study(ies) available for diltiazem and simvastatin

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Non-invasive management of coronary artery disease. Report of a meeting at the University of Texas Medical School at Houston. Lancet (London, England), 1995, Sep-16, Volume: 346, Issue:8977 Topics: Aged; Anticholesteremic Agents; Aspirin; beta Carotene; Carotenoids; Cholesterol, Dietary; Coronary Disease; Diet, Fat-Restricted; Diltiazem; Drug Therapy, Combination; Enalapril; Humans; Lovastatin; Male; Simvastatin; Tomography, Emission-Computed; Vitamins	1995
Sex differences in extracellular and intracellular calcium-mediated vascular reactivity to vasopressin in rat aorta. European journal of pharmacology, 1998, Nov-20, Volume: 361, Issue:2-3 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Sex Characteristics; Simvastatin; Vasoconstriction; Vasopressins	1998
Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients. British journal of clinical pharmacology, 1999, Volume: 48, Issue:4 Topics: Anticholesteremic Agents; Calcium Channel Blockers; Cholesterol; Data Collection; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Patient Dropouts; Simvastatin	1999
Effect of simvastatin on vascular smooth muscle responsiveness: involvement of Ca(2+) homeostasis. European journal of pharmacology, 2001, Volume: 415, Issue:2-3 Topics: Animals; Calcium Signaling; Diltiazem; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Simvastatin; Vasodilation; Vasodilator Agents	2001
Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes. British journal of clinical pharmacology, 2001, Volume: 51, Issue:5 Topics: Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Microsomes, Liver; Simvastatin; Verapamil	2001
Cholesterol reduction, statins and the cytochrome P-450 system. No more recipes please. European heart journal, 2001, Volume: 22, Issue:16 Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Mixed Function Oxygenases; Simvastatin	2001
Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem. Nephron, 2001, Volume: 89, Issue:1 Topics: Aged; Antihypertensive Agents; Diltiazem; Drug Interactions; Drug Therapy, Combination; Humans; Hypolipidemic Agents; Male; Rhabdomyolysis; Simvastatin	2001
Simvastatin-diltiazem drug interaction resulting in rhabdomyolysis and hepatitis. Tennessee medicine : journal of the Tennessee Medical Association, 2001, Volume: 94, Issue:9 Topics: Calcium Channel Blockers; Chemical and Drug Induced Liver Injury; Diltiazem; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Rhabdomyolysis; Simvastatin	2001
Regulation of vascular tone from spontaneously hypertensive rats by the HMG-CoA reductase inhibitor, simvastatin. Pharmacology, 2005, Volume: 74, Issue:4 Topics: Amides; Animals; Aorta, Thoracic; Calcium Chloride; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; In Vitro Techniques; Indoles; Male; Mevalonic Acid; Muscle Relaxants, Central; Norepinephrine; Phenylephrine; Potassium Chloride; Pyridines; Rats; Rats, Inbred SHR; Simvastatin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents	2005
Bilateral posterior ischemic optic neuropathy associated with use of sildenafil. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2008, Volume: 28, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Atenolol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Drugs, Chinese Herbal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypotension; Male; Optic Nerve; Optic Neuropathy, Ischemic; Phosphodiesterase Inhibitors; Piperazines; Purines; Retinal Artery; Risk Factors; Sildenafil Citrate; Simvastatin; Sulfones; Vision, Low	2008
Multiple drug interactions in a renal transplant patient leading to simvastatin-induced rhabdomyolysis: a case report. Medscape journal of medicine, 2008, Volume: 10, Issue:11 Topics: Acetanilides; Adrenergic alpha-Antagonists; Calcium Channel Blockers; Carbazoles; Carvedilol; Diltiazem; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney Transplantation; Male; Middle Aged; Piperazines; Propanolamines; Ranolazine; Rhabdomyolysis; Simvastatin	2008
Chest pain with angiographic clear coronary arteries: A provider's approach to cardiac syndrome X. Journal of the American Academy of Nurse Practitioners, 2009, Volume: 21, Issue:7 Topics: Adrenergic Uptake Inhibitors; Anticholesteremic Agents; Coronary Angiography; Coronary Circulation; Coronary Vessels; Diltiazem; Dyspnea; Female; Humans; Imipramine; Microcirculation; Microvascular Angina; Middle Aged; Nitrates; Risk Factors; Simvastatin; Vasodilator Agents	2009
Approach to the patient who is intolerant of statin therapy. The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:5 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atorvastatin; Coronary Disease; Diltiazem; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Middle Aged; Pyrroles; Simvastatin	2010
Simvastatin-induced myopathy, the role of interaction with diltiazem and genetic predisposition. Journal of clinical pharmacy and therapeutics, 2011, Volume: 36, Issue:3 Topics: Aged, 80 and over; Antihypertensive Agents; Biotransformation; Cytochrome P-450 CYP3A; Diltiazem; Drug Interactions; Female; Hong Kong; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Middle Aged; Muscular Diseases; Polymorphism, Genetic; Simvastatin; Treatment Outcome	2011
Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin. Pharmacological reports : PR, 2011, Volume: 63, Issue:6 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Simvastatin	2011
Management of a mixed overdose of calcium channel blockers, β-blockers and statins. BMJ case reports, 2014, Jun-06, Volume: 2014 Topics: Adrenergic beta-Antagonists; Adult; Bisoprolol; Bradycardia; Calcium Channel Blockers; Cardiac Pacing, Artificial; Diltiazem; Drug Overdose; Fluid Therapy; Glucagon; Heart Block; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Hypotension; Hypothermia; Insulin; Male; Simvastatin; Vasoconstrictor Agents	2014
Assessment of Anti-Xa activity in patients receiving concomitant apixaban with strong p-glycoprotein inhibitors and statins. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:5 Topics: Adult; Aged; Amiodarone; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrazoles; Pyridones; Rosuvastatin Calcium; Simvastatin	2022