diltiazem has been researched along with prazosin in 73 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (20.55) | 18.7374 |
| 1990's | 27 (36.99) | 18.2507 |
| 2000's | 19 (26.03) | 29.6817 |
| 2010's | 11 (15.07) | 24.3611 |
| 2020's | 1 (1.37) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Endo, T; Koshiba, K; Kumano, K | 1 |
| Hitner, HW; Mahalik, MP | 1 |
| Amobi, NI; Smith, IC | 1 |
| Egashira, K; Hayashi, Y; Nakamura, M; Takeshita, A; Tomoike, H; Yamada, A | 1 |
| Fernandez-Alfonso, MS; Guerra, P; Marín, J; Reviriego, J | 1 |
| Endo, T; Kumano, K; Kuwao, S; Wang, G | 1 |
| Dean, MT; Vanhoutte, PM; Wood, MB | 1 |
| Shimizu, M; Yamawaki, S | 1 |
| Andriantsitohaina, R; Stoclet, JC | 1 |
| Butler, BT; Kusiak, JW; Piascik, MT; Pruitt, TA | 1 |
| Endoh, M; Hiramoto, T; Kushida, H | 1 |
| Macaulay, RM; Pearl, RM; Waters, LM | 1 |
| Shinkai, M; Takayanagi, I; Yamasawa, K | 1 |
| Ishii, T; Machida, N; Shimo, Y | 1 |
| Cerný, J; Dostál, M; Gregor, Z; Guba, P; Rebícek, J; Sotolová, O; Urbánek, P; Vasků, A; Vasků, J | 1 |
| Muir, TC; Wardle, KA | 1 |
| De Luca, A; Rand, MJ | 1 |
| Conti, CR | 1 |
| Fujiwara, M; Muramatsu, I | 1 |
| Gordon, M; Nayler, WG; Stephens, DJ; Sturrock, WJ | 1 |
| Schwartz, PJ; Vanoli, E | 1 |
| Messick, K; Morgan, EL; Ruffolo, RR | 1 |
| Medgett, IC; Rajanayagam, MA | 1 |
| Hirakawa, S; Ito, H | 1 |
| Allain, P; Leblondel, G | 1 |
| Bouskela, E; Cyrino, FZ; Marcelon, G | 2 |
| Hosoki, K; Karasawa, T; Sugimoto, T | 1 |
| Hosoki, K; Ikeno, A; Karasawa, T; Kato, H; Kurokawa, M; Masuda, Y; Minato, H; Yamada, T; Zushi, K | 1 |
| Chancellor, MB; Huang, B; Rivas, DA; Salzman, SK | 1 |
| Cushman, WC; Freis, ED; Fye, C; Gottdiener, J; Hamburger, RJ; Kochar, MS; Lakshman, R; Massie, BM; Materson, BJ; Reda, DJ | 1 |
| Cavé, A; Chuliá, S; Cortés, D; D'Ocón, MP; Ivorra, MD; Noguera, MA | 1 |
| Hayashi, K; Kajiyama, G; Kuga, Y; Kuwashima, J; Nomura, K; Nomura, S; Okura, Y; Shingu, T; Tanaka, K; Yasunobu, Y | 1 |
| Bilezikian, JP; Braunstein, V; Chen, B; Christ, GJ; Huang, H; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M | 1 |
| Funakawa, S; Iwaki, K; Masui, M; Matsunaga, K; Mihara, S; Takahara, Y; Uno, O | 1 |
| Ho, IH; Huang, Y | 1 |
| Marwood, JF; Okoro, EO | 1 |
| Anderson, RJ; Gottdiener, JS; Massie, BM; Materson, BJ; Reda, DJ; Williams, DW | 1 |
| Advenier, C; Chulia, S; D'Ocon, P; Elorriaga, M; Ivorra, MD; Lugnier, C; Martinez, S; Noguera, MA; Valiente, M | 1 |
| Cushman, WC; Freis, ED; Lakshman, MR; Materson, BJ; Reda, DJ | 1 |
| Cassels, B; D'Ocon, P; Elorriaga, M; Ivorra, MD; Madrero, Y; Martinez, S; Noguera, MA; Sobarzo, E | 1 |
| Ishibashi, T; Oguma, T; Yano, Y | 1 |
| Eckert, RE; Karsten, AJ; Utz, J; Ziegler, M | 1 |
| Anselmi, E; Bermejo, A; Cabedo, N; Catret, M; Cortes, D; D'Ocon, P; Elorriaga, M; Ivorra, MD; Magraner, J; Tur, R | 1 |
| Cushman, WC; Materson, BJ; Reda, DJ; Williams, DW | 1 |
| Ghosh, B; Reddy, LH | 1 |
| Leenen, FH; Ruzicka, M | 1 |
| Cassels, BK; D'Ocon, MP; Iturriaga-Vásquez, P; Ivorra, MD; Miquel, R | 1 |
| Derumeaux, G; Ferrera, R; Hadour, G; Henry, JP; Mulder, P; Ovize, M; Richard, V; Tamion, F; Thuillez, C | 1 |
| Aboul-Enein, HY; Ali, I; ALOthman, ZA; Alsheetan, KM | 1 |
3 review(s) available for diltiazem and prazosin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Large vessel coronary vasospasm: diagnosis, natural history and treatment.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aspirin; Coronary Artery Bypass; Coronary Disease; Coronary Vasospasm; Diltiazem; Electrocardiography; Epoprostenol; Female; Fibrinolytic Agents; Humans; Isosorbide Dinitrate; Male; Nifedipine; Nitrates; Prazosin; Verapamil | 1985 |
Combination therapy as first-line treatment of arterial hypertension.
Topics: Antihypertensive Agents; Atenolol; Captopril; Diltiazem; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Prazosin; Treatment Outcome | 2002 |
4 trial(s) available for diltiazem and prazosin
| Article | Year |
|---|---|
Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Age Factors; Aged; Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Captopril; Clonidine; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin | 1993 |
Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension: comparison of six antihypertensive agents. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Captopril; Clonidine; Cohort Studies; Diltiazem; Diuretics; Double-Blind Method; Echocardiography; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardium; Organ Size; Prazosin; Prevalence; Risk Factors; Sodium Chloride Symporter Inhibitors; Treatment Outcome; United States; United States Department of Veterans Affairs | 1997 |
Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Captopril; Clonidine; Diltiazem; Diuretics; Double-Blind Method; Hospitals, Veterans; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins; Male; Middle Aged; Potassium; Prazosin; Time Factors; Treatment Outcome; United States | 1999 |
Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Clonidine; Diastole; Diltiazem; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin; Pressure; Pulse; Randomized Controlled Trials as Topic; Systole; Time Factors; Treatment Outcome | 2001 |
66 other study(ies) available for diltiazem and prazosin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
[Functional and morphological changes in rat kidney induced by FK506 and its reversal by various vasodilators].
Topics: Animals; Calcium; Captopril; Diltiazem; Hemodynamics; Kidney; Male; Necrosis; Prazosin; Rats; Rats, Inbred Strains; Tacrolimus | 1992 |
Antagonism of cocaine-induced fetal anomalies by prazosin and diltiazem in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cocaine; Diltiazem; Dose-Response Relationship, Drug; Female; Fetal Resorption; Male; Mice; Organ Size; Prazosin; Pregnancy; Teratogens; Vasoconstriction | 1992 |
Effects of thioridazine on mechanical responses of human vas deferens induced by noradrenaline or potassium.
Topics: Culture Techniques; Diltiazem; Humans; Male; Muscle Contraction; Norepinephrine; Phentolamine; Potassium; Prazosin; Thioridazine; Vas Deferens; Verapamil | 1992 |
Mechanism of ergonovine-induced hyperconstriction of the large epicardial coronary artery in conscious dogs a month after arterial injury.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Diltiazem; Dogs; Electrophysiology; Endothelium, Vascular; Ergonovine; Heart Rate; Indomethacin; Ketanserin; Methysergide; Phenylephrine; Prazosin; Receptors, Serotonin | 1992 |
Effects of Ca2+ antagonists nifedipine and diltiazem on isolated human chorionic arteries and veins.
Topics: Arteries; Calcium; Calcium Radioisotopes; Diltiazem; Female; Humans; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Placenta; Potassium; Prazosin; Pregnancy; Regional Blood Flow; Serotonin; Veins | 1990 |
FK 506-induced nephrotoxicity in rats.
Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Captopril; Diltiazem; Glomerular Filtration Rate; Immunosuppressive Agents; Kidney; Male; Organ Size; Prazosin; Rats; Rats, Inbred Strains; Reference Values; Renal Circulation; Tacrolimus; Vascular Resistance | 1991 |
Antagonist drugs and bone vascular smooth muscle.
Topics: Animals; Bone and Bones; Diltiazem; Dogs; Dose-Response Relationship, Drug; Microcomputers; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Software; Sympatholytics; Vasoconstriction; Yohimbine | 1992 |
Effects of Ca2+ antagonists on NA-induced intracellular Ca2+ mobilization in rat cultured neurons.
Topics: Animals; Calcium; Cells, Cultured; Diltiazem; Frontal Lobe; Intracellular Fluid; Neurons; Nicardipine; Norepinephrine; Prazosin; Rats; Verapamil | 1991 |
Enhancement by neuropeptide Y (NPY) of the dihydropyridine-sensitive component of the response to alpha 1-adrenoceptor stimulation in rat isolated mesenteric arterioles.
Topics: Adrenergic alpha-Agonists; Animals; Arterioles; Calcium Channel Blockers; Colforsin; Dihydropyridines; Diltiazem; Female; In Vitro Techniques; Mesenteric Arteries; Muscle, Smooth, Vascular; Neuropeptide Y; Nitroprusside; Norepinephrine; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains | 1990 |
Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Clonidine; Diltiazem; Dioxanes; Drug Interactions; Heart; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Myocardium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
The preferential inhibition of alpha 1- over beta-adrenoceptor-mediated positive inotropic effect by organic calcium antagonists in the rabbit papillary muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Nifedipine; Papillary Muscles; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Subcellular Fractions; Verapamil | 1990 |
A comparative analysis of the ability of five classes of pharmacological agents to augment skin flap survival in various models and species: an attempt to standardize skin flap research.
Topics: Animals; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation, Preclinical; Graft Survival; Isoxsuprine; Macaca nemestrina; Male; Methyldopa; Nitroglycerin; Prazosin; Rats; Surgical Flaps | 1989 |
Effects of aging on alpha 1-adrenoceptor mechanisms and the inhibitory effect of diltiazem on noradrenaline maximum response in isolated rat aortic preparation.
Topics: Aging; Animals; Aorta, Thoracic; Diltiazem; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin | 1989 |
Influence of cooling on the responsiveness of rat isolated anococcygeus muscle to noradrenaline.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Cold Temperature; Diltiazem; Drug Interactions; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Muscles; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Vanadates | 1989 |
[Therapy of venous hypertension in animals with an artificial heart and long-term survival].
Topics: Animals; Antihypertensive Agents; Captopril; Cattle; Clonidine; Diltiazem; Heart, Artificial; Methyldopa; Nifedipine; Prazosin; Venous Pressure | 1989 |
Vascular smooth muscle responses in normo- and hypertensive rats to sympathetic nerve stimulation and putative transmitters.
Topics: Adenosine Triphosphate; Animals; Diltiazem; Electric Stimulation; Epinephrine; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System | 1989 |
Involvement of alpha 1-adrenoceptors in chronotropic responses to endogenously released amines in the pithed rat.
Topics: Animals; Biogenic Amines; Decerebrate State; Diltiazem; Drug Interactions; Electric Stimulation; Heart Rate; Male; Nerve Endings; Norepinephrine; Prazosin; Propranolol; Rats; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Tyramine; Yohimbine | 1988 |
[Vasorelaxing action of nicorandil, in comparison with nitroglycerin and Ca antagonists].
Topics: Animals; Aorta; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Drug Interactions; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil | 1986 |
The protective effect of prazosin on the ischaemic and reperfused myocardium.
Topics: Adenosine Triphosphate; Animals; Calcium; Coronary Disease; Diltiazem; Male; Myocardial Contraction; Myocardium; Phosphocreatine; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha | 1985 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Possible relationship between receptor reserve and the differential antagonism of alpha-1 and alpha-2 adrenoceptor-mediated pressor responses by calcium channel antagonists in the pithed rat.
Topics: Animals; Aorta, Thoracic; Azepines; Blood Pressure; Decerebrate State; Diltiazem; Dose-Response Relationship, Drug; Imidazoles; Male; Muscle Contraction; Phenoxybenzamine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1984 |
Effects of reduced calcium ion concentration and of diltiazem on vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation in rat isolated tail artery.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Calcium; Diltiazem; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Tail; Vasoconstriction | 1984 |
Effects of vasodilators on the systemic capacitance vessels, a study with the measurement of the mean circulatory pressure in dogs.
Topics: Animals; Blood Pressure; Blood Vessels; Blood Volume; Cardiac Output; Diltiazem; Dogs; Heart Rate; Isosorbide Dinitrate; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Prazosin; Sydnones; Trapidil; Vascular Resistance; Vasodilator Agents; Venous Pressure; Verapamil | 1984 |
Ca2+ uptake and energy supply of sheep heart mitochondria in presence of some calcium antagonists.
Topics: Animals; Bepridil; Calcium; Calcium Channel Blockers; Diltiazem; Energy Metabolism; Mitochondria, Heart; Nifedipine; Prazosin; Pyrrolidines; Sheep | 1984 |
Possible mechanisms for the venular constriction elicited by Ruscus extract on hamster cheek pouch.
Topics: Adrenergic alpha-Antagonists; Animals; Arterioles; Calcium; Cheek; Cricetinae; Diltiazem; Male; Plant Extracts; Prazosin; Vascular Resistance; Venules | 1994 |
Possible mechanisms for the inhibitory effect of Ruscus extract on increased microvascular permeability induced by histamine in hamster cheek pouch.
Topics: Animals; Capillary Permeability; Cheek; Cricetinae; Diltiazem; Dose-Response Relationship, Drug; Histamine; Male; Mesocricetus; Plant Extracts; Prazosin | 1994 |
Relative contribution of alpha 1-adrenoceptor blocking activity to the hypotensive effect of the novel calcium antagonist monatepil.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Decerebrate State; Dibenzothiepins; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Hypotension; Injections, Intravenous; Piperazines; Prazosin; Rats; Rats, Wistar | 1995 |
Inhibitory effect of the new calcium antagonist AJ-2615 on progression of atherosclerosis in cholesterol-fed rabbits.
Topics: Animals; Arteriosclerosis; Calcium Channel Blockers; Cholesterol, Dietary; Dibenzothiepins; Diltiazem; Male; Phospholipids; Piperazines; Prazosin; Rabbits; Triglycerides | 1993 |
Autonomic dysreflexia in a rat model spinal cord injury and the effect of pharmacologic agents.
Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System Diseases; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Male; Mandelic Acids; Parasympatholytics; Prazosin; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Urinary Bladder, Neurogenic; Urodynamics | 1995 |
Relaxant activity of three aporphine alkaloids from Annona cherimolia on isolated aorta of rat.
Topics: Alkaloids; Animals; Antioxidants; Aorta, Thoracic; Aporphines; Calcium; Calcium Channel Blockers; Diltiazem; Dioxoles; Drugs, Chinese Herbal; Isoquinolines; Lipoxygenase Inhibitors; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Potassium Chloride; Prazosin; Rats; Rats, Wistar; Sympatholytics | 1995 |
Inhibition of lipid hydroperoxidation of low density lipoprotein by the Ca(2+)-channel and alpha 1-adrenoceptor antagonist monatepil maleate.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Anticholesteremic Agents; Calcium Channel Blockers; Copper; Copper Sulfate; Depression, Chemical; Dibenzothiepins; Diltiazem; Humans; In Vitro Techniques; Lipid Peroxidation; Lipoproteins, LDL; Piperazines; Prazosin; Probucol | 1996 |
Effects of verapamil on acute murine Chagas' disease.
Topics: Acute Disease; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Cells, Cultured; Chagas Disease; Diltiazem; Endothelium, Vascular; GTP-Binding Proteins; Humans; Male; Mice; Myocardium; Prazosin; Propranolol; Trypanosoma cruzi; Umbilical Veins; Verapamil | 1996 |
Pharmacological studies on a new antihypertensive agent, S-2150, a benzothiazepine derivative: 1. Antinecrotic and antiarrhythmic effects in reperfused rat hearts.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Coronary Circulation; Creatine Kinase; Diltiazem; Drug Therapy, Combination; Heart; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Necrosis; Prazosin; Protein Binding; Rats; Rats, Wistar; Vasodilator Agents | 1996 |
Separate activation of intracellular Ca2+ release, voltage-dependent and receptor-operated Ca2+ channels in the rat aorta.
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dose-Response Relationship, Drug; Male; Nifedipine; Prazosin; Rats; Rats, Sprague-Dawley | 1996 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female; In Vitro Techniques; Ketanserin; Male; Mianserin; Muscle Contraction; Nifedipine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reproducibility of Results; Ritanserin; Serotonin Antagonists; Verapamil | 1997 |
Relationships between structure and vascular activity in a series of benzylisoquinolines.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta; Diltiazem; Female; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Papaverine; Parasympatholytics; Prazosin; Radioligand Assay; Rats; Structure-Activity Relationship | 1997 |
Halogenated derivatives of boldine with high selectivity for alpha1A-adrenoceptors in rat cerebral cortex.
Topics: Animals; Aporphines; Binding, Competitive; Cerebral Cortex; Diltiazem; Female; Halogens; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Structure-Activity Relationship | 1999 |
Pharmacodynamics of S-2150, a simultaneous calcium-blocking and alpha1-inhibiting antihypertensive drug, in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Male; Metabolic Clearance Rate; Prazosin; Rats; Rats, Inbred SHR; Time Factors | 2000 |
Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Diltiazem; Dioxanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Ischemia; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Phenoxybenzamine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Renal Artery; Renal Circulation; Swine; Thapsigargin; Verapamil | 2000 |
Mechanism of vascular relaxation by thaligrisine: functional and binding assays.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Aorta, Thoracic; Arteries; Binding Sites; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Diltiazem; Female; In Vitro Techniques; Membranes; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrendipine; Norepinephrine; Potassium Chloride; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tail; Trees; Tritium; Vasoconstrictor Agents | 2000 |
Effect of physicochemical parameters on skin permeability of antihypertensive.
Topics: Administration, Cutaneous; Animals; Antihypertensive Agents; Atenolol; Chemical Phenomena; Chemistry, Physical; Diltiazem; Female; In Vitro Techniques; Mice; Permeability; Prazosin; Propranolol; Reserpine; Skin | 2001 |
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action.
Topics: Alkaloids; Antihypertensive Agents; Benzylisoquinolines; Calcium Channel Blockers; Combinatorial Chemistry Techniques; Diltiazem; Inhibitory Concentration 50; Isoquinolines; Molecular Conformation; Molecular Mimicry; Molecular Structure; Prazosin; Stereoisomerism; Structure-Activity Relationship | 2003 |
Brain death provokes very acute alteration in myocardial morphology detected by echocardiography: preventive effect of beta-blockers.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Brain Death; Calcium Channel Blockers; Diltiazem; Echocardiography; Edema; Heart Rate; Male; Myocardium; Prazosin; Propanolamines; Rats; Rats, Wistar | 2011 |
Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma.
Topics: Adsorption; Antihypertensive Agents; Chromatography, High Pressure Liquid; Diltiazem; Furosemide; Humans; Hydrochlorothiazide; Irbesartan; Iron; Labetalol; Limit of Detection; Losartan; Metal Nanoparticles; Methyldopa; Nanocomposites; Polyvinyl Alcohol; Prazosin; Propranolol; Reproducibility of Results; Solid Phase Microextraction; Spironolactone; Valsartan | 2020 |