Page last updated: 2024-08-23

diltiazem and piperidines

diltiazem has been researched along with piperidines in 25 studies

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19904 (16.00)18.7374
1990's15 (60.00)18.2507
2000's4 (16.00)29.6817
2010's2 (8.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Berga, P; Bou, J; Cardelús, I; Gristwood, RW; Llenas, J1
Berga, P; Furman, BL; Gristwood, RW; Jauregui, J; Llenas, J1
Crosland, RD1
Chiba, S; Tsukada, M1
Peters, T; Scheufler, E1
Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G1
Kienast, J; Verstraete, M1
Ishikawa, T; Murakami, H; Watanabe, H1
Koch, P; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wilhelm, D1
Antman, EM; Braunwald, E; Muller, JE; Stone, PH1
Berger, W; Friedrich, K; Garcia, ML; Glossmann, H; Goetz, MA; Hering, S; Kaczorowski, GJ; Liesch, JM; Savchenko, A; Zink, DL1
Dong, H; Lee, CM; Sheng, JZ; Wong, TM1
Clarke, W; Cohen, AH; Fouty, B; Hanson, K; McMurty, IF; Morris, K; Rodman, DM1
Okabe, S; Takahashi, S1
Adachi, Y; Akima, M; Fukazawa, M; Kato, T; Koga, T; Kuromaru, O; Suzuki, Y; Tamura, K1
Aida, M; Saito, W; Saito, Y; Sasaki, M; Shigenobu, K; Tanaka, H; Tanaka, Y1
Adachi, Y; Fukazawa, M; Homma, N; Kuromaru, O; Nishie, I; Suzuki, Y; Tamura, K1
Lawrence, C; Rodrigo, GC1
Enyeart, JJ; Gomora, JC1
Kou, JH; Saha, P1
Imai, T; Koike, K; Okamoto, T; Shigenobu, K; Tanaka, H; Tanaka, Y; Yamamoto, Y1
Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA1
Kim, JY; Mehanna, AS1
Han, HK; Kang, KW; Qiang, F1
Budha, NR; Chen, Y; Dresser, M; Eppler, S; Ji, T; Jin, JY; Musib, L1

Reviews

2 review(s) available for diltiazem and piperidines

ArticleYear
Pharmacology of the interaction between platelets and vessel wall.
    Clinics in haematology, 1986, Volume: 15, Issue:2

    Topics: Animals; Aspirin; Blood Platelets; Blood Vessels; Dextrans; Diltiazem; Dipyridamole; Epoprostenol; Humans; Imidazoles; Ketanserin; Piperidines; Pyrazoles; Pyrazolones; Sulfinpyrazone; Sulfonamides; Thiophenes; Ticlopidine

1986
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications.
    Annals of internal medicine, 1980, Volume: 93, Issue:6

    Topics: Benzazepines; Calcium Channel Blockers; Cardiovascular Diseases; Coronary Circulation; Diltiazem; Hemodynamics; Humans; Myocardial Contraction; Nifedipine; Nitrogen; Perhexiline; Piperidines; Pyridines; Regional Blood Flow; Vasodilation; Verapamil

1980

Other Studies

23 other study(ies) available for diltiazem and piperidines

ArticleYear
Cardiovascular effects of LAS 30538, a new vascular selective Ca(2+)-channel blocker.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:10

    Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Electrophysiology; Flunarizine; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Papillary Muscles; Perfusion; Piperidines; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents; Verapamil

1992
The calcium channel blocker LAS 30538, unlike nifedipine, verapamil, diltiazem or flunarizine, potently inhibits insulin secretion in-vivo in rats and dogs.
    The Journal of pharmacy and pharmacology, 1992, Volume: 44, Issue:10

    Topics: Administration, Oral; Animals; Blood Glucose; Calcium Channel Blockers; Diltiazem; Dogs; Female; Flunarizine; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nifedipine; Piperidines; Rats; Rats, Sprague-Dawley; Verapamil

1992
Effect of drugs on the lethality in mice of the venoms and neurotoxins from sundry snakes.
    Toxicon : official journal of the International Society on Toxinology, 1991, Volume: 29, Issue:6

    Topics: Animals; Dexamethasone; Diltiazem; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Neuromuscular Depolarizing Agents; Neurotoxins; Nicergoline; Nifedipine; Piperidines; Piracetam; Primaquine; Reserpine; Snake Venoms; Snakes; Verapamil

1991
Predominant acetylcholine-induced vasoconstriction in isolated, perfused simian facial veins.
    European journal of pharmacology, 1990, Dec-04, Volume: 191, Issue:3

    Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Atropine; Blood Pressure; Diltiazem; Face; Female; In Vitro Techniques; Macaca; Male; Muscle, Smooth, Vascular; Parasympatholytics; Physostigmine; Piperidines; Pirenzepine; Potassium Chloride; Quinazolines; Receptors, Muscarinic; Saponins; Vasoconstriction; Veins

1990
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
    Cell biology international reports, 1990, Volume: 14, Issue:4

    Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil

1990
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes.
    Cell biology international reports, 1990, Volume: 14, Issue:4

    Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil

1990
Effects of Ca-antagonists and antispasmodic drugs on contraction by ACh in molluscan smooth muscle.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1985, Volume: 80, Issue:1

    Topics: Acetylcholine; Animals; Bivalvia; Calcium Channel Blockers; Diltiazem; Dimethylphenylpiperazinium Iodide; Drug Interactions; Gallopamil; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Papaverine; Parasympatholytics; Piperidines; Verapamil

1985
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta.
    European journal of pharmacology, 1988, Dec-13, Volume: 158, Issue:3

    Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil

1988
A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, Oct-15, Volume: 90, Issue:20

    Topics: Alkaloids; Animals; Benzylisoquinolines; Binding, Competitive; Calcium Channel Blockers; Cell Line; Decanoic Acids; Dihydropyridines; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Piperidines; Polypropylenes; Rabbits; Swine; Verapamil

1993
Calcium antagonistic and antiarrhythmic actions of CPU-23, a substituted tetrahydroisoquinoline.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: Action Potentials; Anesthesia; Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Coronary Vessels; Diltiazem; Female; Guinea Pigs; Heart Rate; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Myocardium; Nifedipine; Papillary Muscles; Piperidines; Potassium Chloride; Rabbits; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Tetrahydroisoquinolines

1993
Inhibition of cyclic 3'-5'-guanosine monophosphate-specific phosphodiesterase selectively vasodilates the pulmonary circulation in chronically hypoxic rats.
    The Journal of clinical investigation, 1996, Jan-01, Volume: 97, Issue:1

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium Channel Blockers; Cyclic GMP; Diltiazem; Hemodynamics; Hypertension, Pulmonary; Hypoxia; In Vitro Techniques; Lung; Male; Nitric Oxide; Perfusion; Phosphodiesterase Inhibitors; Piperidines; Pulmonary Circulation; Purinones; Quinazolines; Rats; Rats, Sprague-Dawley; Vasodilation

1996
Roles of extracellular Ca++ and calmodulin in roxatidine-stimulated secretion and synthesis of mucus by cultured rabbit gastric mucosal cells.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:1

    Topics: Animals; Calcium; Calmodulin; Cells, Cultured; Diltiazem; Gastric Mucosa; Histamine H2 Antagonists; Male; Mucus; Nifedipine; Piperidines; Rabbits; Sulfonamides

1998
The protective effects of CP-060S on ischaemia- and reperfusion- induced arrhythmias in anaesthetized rats.
    British journal of pharmacology, 1998, Volume: 123, Issue:7

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Diltiazem; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion; Piperidines; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines

1998
Differential sensitivity to ATP-sensitive potassium channel openers of norepinephrine-induced contraction of guinea pig and rat aorta.
    Life sciences, 1998, Volume: 62, Issue:24

    Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Cromakalim; Diltiazem; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxadiazoles; Piperidines; Potassium Channels; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation

1998
The anti-ischemic effects of CP-060S during pacing-induced ischemia in anesthetized dogs.
    European journal of pharmacology, 1999, Feb-19, Volume: 367, Issue:2-3

    Topics: Anesthesia; Animals; Benzothiazoles; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dogs; Drug Synergism; Electrocardiography; Ischemia; Male; Piperidines; Thiazoles; Thiazolidines

1999
A Na+-activated K+ current (IK,Na) is present in guinea-pig but not rat ventricular myocytes.
    Pflugers Archiv : European journal of physiology, 1999, Volume: 437, Issue:6

    Topics: Animals; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Electric Conductivity; Glyburide; Guinea Pigs; Heart; Magnesium; Male; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase; Thiazoles; Ventricular Function

1999
Dual pharmacological properties of a cyclic AMP-sensitive potassium channel.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1

    Topics: Animals; Antipsychotic Agents; Calcium Channel Blockers; Cattle; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Diltiazem; In Vitro Techniques; Ion Channel Gating; Ion Channels; Male; Membrane Potentials; Patch-Clamp Techniques; Penfluridol; Piperidines; Potassium Channel Blockers; Potassium Channels; Zona Fasciculata

1999
Effect of solubilizing excipients on permeation of poorly water-soluble compounds across Caco-2 cell monolayers.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2000, Volume: 50, Issue:3

    Topics: Alkaloids; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cimetidine; Diltiazem; Excipients; Furans; Humans; Hydrogen-Ion Concentration; Imidazoles; Intestinal Absorption; Naphthalenes; Phenytoin; Piperidines; Poloxamer; Polyethylene Glycols; Povidone; Propranolol; Solubility; Triazoles

2000
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
    Acta physiologica Scandinavica, 2001, Volume: 173, Issue:3

    Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Blockers; Cation Transport Proteins; Cromakalim; Diltiazem; Ether-A-Go-Go Potassium Channels; Female; Glyburide; Guinea Pigs; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Muscle, Smooth; Nisoldipine; Parasympatholytics; Peptides; Periodicity; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Pyridines; Small-Conductance Calcium-Activated Potassium Channels; Urinary Bladder

2001
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 2003, Volume: 19, Issue:6

    Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil

2003
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers.
    Bioorganic & medicinal chemistry, 2005, Jul-01, Volume: 13, Issue:13

    Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels; Diltiazem; Drug Design; Male; Molecular Structure; Piperazine; Piperazines; Piperidines; Rats; Rats, Wistar; Salicylamides; Structure-Activity Relationship

2005
Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats.
    Biopharmaceutics & drug disposition, 2012, Volume: 33, Issue:8

    Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Availability; Calcium Channel Blockers; Diltiazem; Food-Drug Interactions; Gene Expression; Hep G2 Cells; Humans; Male; Piperidines; Polyunsaturated Alkamides; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Steroid

2012
Evaluation of Cytochrome P450 3A4-Mediated Drug-Drug Interaction Potential for Cobimetinib Using Physiologically Based Pharmacokinetic Modeling and Simulation.
    Clinical pharmacokinetics, 2016, Volume: 55, Issue:11

    Topics: Administration, Oral; Alkynes; Area Under Curve; Azetidines; Benzoxazines; Computer Simulation; Cyclopropanes; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Erythromycin; Fluvoxamine; Humans; Models, Biological; Piperidines; Retrospective Studies; Rifampin

2016