diltiazem has been researched along with nitrendipine in 148 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 77 (52.03) | 18.7374 |
| 1990's | 45 (30.41) | 18.2507 |
| 2000's | 14 (9.46) | 29.6817 |
| 2010's | 12 (8.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adams, TC; Carter, JP; Dupont, AC; Farmer, SG; Guzewska, ME; Kachur, JF; Kaiser, C; Noronha-Blob, L; Rzeszotarski, WJ | 1 |
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Janis, RA; Triggle, DJ | 1 |
| Coassolo, P; Lavé, T; Schneider, G | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Horinouchi, M; Komada, F; Nishiguchi, K; Ohmoto, N; Ohnishi, N; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y; Yokoyama, T | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Keserü, GM | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Bills, GF; de Pedro, N; El Aouad, N; Genilloud, O; Goetz, MA; González-Menéndez, V; Martín, J; Ortiz-López, FJ; Pérez-Victoria, I; Platas, G; Reyes, F; Tormo, JR; Vicente, F | 1 |
| Carmody, LC; Dandapani, S; Donckele, E; Feng, Y; Fernandez, C; Germain, AR; Gupta, PB; Lander, ES; Morgan, B; Munoz, B; Nag, PP; Palmer, M; Perez, JR; Schreiber, SL; Verplank, L | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Li, QP; Liu, TP | 1 |
| Schoemaker, H | 1 |
| Staneva-Stoytcheva, D; Venkova, K | 1 |
| Heym, J; McLean, S; Schmidt, AW | 1 |
| Mason, RP; Moisey, DM; Shajenko, L | 1 |
| Gürdal, H; Sara, Y; Tulunay, FC | 1 |
| Lugnier, C; Schaeffer, P; Stoclet, JC | 1 |
| Baydoun, AR; Markham, A; Morgan, RM; Sweetman, AJ | 1 |
| Ballesta, JJ; Garcia, AG; Gutierrez, LM; Hidalgo, MJ; Palmero, M; Reig, JA; Viniegra, S | 1 |
| Gambini, F; Gaviraghi, G; Micheli, D; Quartaroli, M; Tarter, G; Trist, DG | 1 |
| Andreyev, N; Andreyeva, T; Bichkov, I; Skutelis, A | 1 |
| Miyamae, S | 1 |
| Abbate, R; Boddi, M; Coppo, M; Gensini, GF; Neri Serneri, GG; Prisco, D; Rostagno, C | 1 |
| Angus, JA; Coe, SA; Kawabata, H; Knight, KR; O'Brien, BM | 1 |
| Masumoto, N; Miyake, A; Tanizawa, O; Tasaka, K | 1 |
| Kurosawa, H; Naito, K; Ohashi, M; Otsuka, M; Suzuki, T; Takaiti, O | 1 |
| Böhm, M; Erdmann, E; Schwinger, RH | 1 |
| Gordon, T; Howlett, SE | 1 |
| Hunter, JB; Pegram, BL; Peters, T; Scheufler, E; Vogelgesang, R; Wermelskirchen, D; Wilffert, B | 1 |
| Gaino, M; Inoue, H; Kurosawa, H; Nagao, T; Narita, H; Suzuki, T | 1 |
| Peters, T; Scheufler, E | 1 |
| Cattaneo, EA; Cingolani, HE; Rinaldi, GJ | 1 |
| Langer, SZ; Schoemaker, H | 2 |
| Batra, S | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 1 |
| Aguilera, G; Catt, KJ | 1 |
| Bryant, SH; Schwartz, A; Walsh, KB | 2 |
| Garcia, ML; Kaczorowski, GJ; King, VF; Reuben, JP; Siegl, PK | 1 |
| Andresen, MC; Kunze, DL; Torres, LA | 1 |
| Hosey, MM; Maan, AC; Ptasienski, J | 1 |
| Cornwell, MM; Gottesman, MM; Pastan, I | 1 |
| Hicks, PE; Langer, SZ; Schoemaker, H | 1 |
| Janis, RA; Sarmiento, JG; Shrikhande, AV; Triggle, DJ | 1 |
| Mir, AK; Spedding, M | 1 |
| Kjellstedt, A; Ljung, B; Orebäck, B | 1 |
| Garcia, ML; Han, GQ; Himmel, D; Kaczorowski, GJ; King, VF; Lam, YK; Pan, JX; Reuben, JP | 1 |
| Carboni, E; Wojcik, WJ | 1 |
| Marwood, JF | 1 |
| Burges, RA; Carter, AJ; Gardiner, DG | 1 |
| Donowitz, M; Homaidan, FR; Sharp, GW; Weiland, GA | 1 |
| Avioli, LV; Civitelli, R; Fausto, A; Gunsten, SL; Hruska, KA; Martin, TJ | 1 |
| Cohen, ML; Schoepp, DD; Secrest, RJ | 1 |
| Belin, C; Carriot, T; Doble, A; Dubroeucq, MC; Guérémy, C; Le Fur, G; Mestre, M; Renault, C; Uzan, A | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Linn, T | 1 |
| Cohen, ML; Secrest, RJ | 1 |
| Artalejo, CR; Castillo, CF; García, AG; López, MG; Moro, MA | 1 |
| Keene, F; Lechner, W; Marth, C; Zech, J | 1 |
| Cheng, HC; Dudley, MW; Mir, AK; Obata, T; Palfreyman, MG; Roeske, WR; Yamada, S; Yamamura, HI | 1 |
| Brush, KL; Hamilton, SL; Hawkes, MJ; Perez, M; Pratt, DR | 1 |
| Garcia, ML; Kaczorowski, GJ; King, VF; Morgan, G; Scott, AL; Siegl, PK | 1 |
| O'Donnell, SR; Wanstall, JC | 1 |
| Balwierczak, JL; Schwartz, A | 1 |
| Frohlich, ED | 1 |
| Bauer, JH; Reams, G; Sunderrajan, S | 1 |
| Aihara, H; Fujita, A; Muramatsu, M; Tanaka, M | 1 |
| Balwierczak, JL; Grupp, G; Grupp, IL; Schwartz, A | 1 |
| Cruz, LJ; Olivera, BM | 1 |
| Bolger, GT; Rafferty, MF; Skolnick, P | 1 |
| Brown, NL; Sirugue, O; Worcel, M | 1 |
| Carpenter, R; Cohen, ML; Mason, N; Schenck, K; Wittenauer, L | 1 |
| Farmer, BB; Green, FJ; Jose, MJ; Watanabe, AM; Wiseman, GL | 1 |
| Bolger, GT; Ruzycky, A; Triggle, DJ; Yousif, FB | 1 |
| Dhalla, NS; Elimban, V; Takeo, S | 1 |
| Donoso, P; Hidalgo, C; Jaimovich, E; Liberona, JL | 1 |
| Kanaide, H; Miwa, N; Nakamura, M; Nishimura, J | 1 |
| Barbieri, L; Camerini, F; Mestroni, L | 1 |
| Andrejauskas, E; Hertel, R; Marmé, D | 1 |
| Karasawa, A; Kubo, K; Nakamizo, N; Oka, T | 1 |
| Ceschia, G; Pandullo, C; Pivotti, F; Salvi, A; Scardi, S | 1 |
| Glossmann, H; Zernig, G | 1 |
| Fleming, JT; Parekh, N; Steinhausen, M | 1 |
| Endou, K; Sato, T; Yamamoto, H | 1 |
| Mooy, JM; Rahn, KH; van Bortel, LM | 1 |
| Bush, LR; D'Alonzo, AJ; Evans, RM; Gaul, SL | 1 |
| Johns, EJ; Manitius, J | 1 |
| Fischli, W; Hengartner, U; Holck, M | 1 |
| Kirley, TL; Schwartz, A | 1 |
| Fosset, M; Galizzi, JP; Lazdunski, M | 1 |
| Garcia, ML; Kaczorowski, GJ; Reuben, JP; Trumble, MJ | 1 |
| Johnson, CE; Scriabine, A; Steinsland, OS | 1 |
| Bühler, FR | 1 |
| Freedman, SB; Miller, DM; Miller, RJ; Tindall, DR | 1 |
| Freedman, SB; Miller, RJ | 1 |
| DePover, A; Dubé, GP; Grupp, G; Grupp, IL; Lee, SW; Matlib, MA; Schwartz, A | 1 |
| Boles, RG; Roeske, WR; Schoemaker, H; Yamamura, HI | 3 |
| Lee, KS; Tsien, RW | 1 |
| Barry, WH; Lachance, D; Loh, E; Marsh, JD; Smith, TW | 1 |
| Gould, RJ; Murphy, KM; Snyder, SH | 1 |
| Rudolph, SA; Thorgeirsson, G | 1 |
| Aguilera, G; Catt, KJ; Finkel, MS; Keiser, HR | 1 |
| Gopalakrishnan, V; Triggle, CR | 1 |
| Henry, PD; Wahl, AM | 1 |
| Ehlert, FJ; Itoga, E; Roeske, WR; Yamamura, HI | 1 |
| Botta, M; Bruni, G; Budriesi, R; Campiani, G; Chiarini, A; Fiorini, I; Garofalo, A; Nacci, V; Romeo, MR; Tafi, A | 1 |
| Mimran, A; Ribstein, J; Sissmann, J | 1 |
| Little, HJ; Watson, WP | 1 |
| García, AG; Guantes, JM; Michelena, P; Montiel, C; Uceda, G | 1 |
| Floersheim, GL; Racine, C | 1 |
| Akimoto, T; Ichida, S; Kishino, H; Matsuda, N; Nakazaki, S; Wada, T | 1 |
| Alabaster, VA; Cheeseman, HE; Cooper, K; deSouza, RN; Keir, RF; Parry, MJ | 1 |
| Czirfuzs, A; Fleckenstein-Grün, G; Frey, M; Matyas, S; Thimm, F | 1 |
| Jacobs, U; Klehr, HU; Klein, B | 1 |
| Hori, R; Komano, T; Saeki, T; Tanigawara, Y; Ueda, K | 1 |
| Chen, Y; Fukuo, K; Jiang, B; Kimura, T; Kitano, S; Koh, E; Morimoto, S; Ogihara, T; Sakakibara, S; Yasuda, O | 1 |
| Floersheim, GL | 1 |
| Kikuchi, K; Sugawara, H; Tobise, K | 1 |
| Botta, M; Campiani, G; Corelli, F; Manetti, F; Nacci, V; Tafi, A | 1 |
| Brauns, T; Glossmann, H; Haugland, RP; Kimball, SD; Prinz, H; Striessnig, J | 1 |
| Koizumi, S; Moriyama, Y; Ogura, A; Yamada, H; Yamaguchi, A | 1 |
| Adachi-Akahane, S; Kanda, S; Nagao, T | 1 |
| Campbell, DB; Hess, EJ | 1 |
| Melena, J; Osborne, NN; Wood, JP | 1 |
| Nagao, T; Nishida, M; Sakamoto, K; Urushidani, T | 1 |
| Drew, T; Jinnah, HA; Kim, BS; Rothstein, JD; Visser, JE; Yitta, S | 1 |
| Anselmi, E; Bermejo, A; Cabedo, N; Catret, M; Cortes, D; D'Ocon, P; Elorriaga, M; Ivorra, MD; Magraner, J; Tur, R | 1 |
| Arányi, P; Finance, O; Tömösközi, Z | 1 |
| Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA | 1 |
| Andersen, E; Gopalakrishnan, M; Grønlien, JH; Lee, CH; Malysz, J; Thorin-Hagene, K; Ween, H | 1 |
| Chengliang, Z; Dong, L; Tao, W; Xiping, L; Xiuhua, R; Yanjiao, X | 1 |
3 review(s) available for diltiazem and nitrendipine
| Article | Year |
|---|---|
New developments in Ca2+ channel antagonists.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calmodulin; Electrophysiology; Heart; Humans; Ion Channels; Muscle Relaxation; Muscle, Smooth; Potassium; Sodium; Structure-Activity Relationship; Substrate Specificity | 1983 |
Effects of calcium entry blockers on renin-angiotensin-aldosterone system, renal function and hemodynamics, salt and water excretion and body fluid composition.
Topics: Animals; Blood Pressure; Body Fluids; Calcium Channel Blockers; Diltiazem; Diuresis; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Nifedipine; Nitrendipine; Renal Circulation; Renin-Angiotensin System; Verapamil; Water-Electrolyte Balance | 1985 |
[Calcium antagonists in congestive heart failure].
Topics: Calcium Channel Blockers; Cardiomyopathy, Dilated; Diltiazem; Felodipine; Heart Failure; Hemodynamics; Humans; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Verapamil | 1988 |
3 trial(s) available for diltiazem and nitrendipine
| Article | Year |
|---|---|
Comparison of diltiazem, nitrendipine, and their combination for systemic hypertension and stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Nitrendipine | 1991 |
Calcium antagonists, firstline partners for betablockers in hypertension.
Topics: Adrenergic beta-Antagonists; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Hemodynamics; Humans; Hypertension; Nifedipine; Nitrendipine; Renin; Verapamil | 1984 |
Effects of calcium antagonists on adrenaline-induced hypokalaemia.
Topics: Adult; Aged; Blood Glucose; Calcium Channel Blockers; Diltiazem; Epinephrine; Hemodynamics; Humans; Hypokalemia; Middle Aged; Nitrendipine; Potassium; Renin; Verapamil | 1993 |
142 other study(ies) available for diltiazem and nitrendipine
| Article | Year |
|---|---|
Aminoalkynyldithianes. A new class of calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Cells, Cultured; Chemical Phenomena; Chemistry; Guinea Pigs; Heterocyclic Compounds; Muscle, Smooth; Structure-Activity Relationship | 1991 |
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques.
Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Gene Expression; Humans; Nifedipine; Paclitaxel; RNA, Messenger; Swine; Tritium; Tumor Cells, Cultured; Verapamil; Vinblastine | 2002 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica.
Topics: Amino Acids; Ascomycota; Calcium Channels, L-Type; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fermentation; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Vasodilator Agents | 2012 |
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Topics: Amides; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Humans; Neoplastic Stem Cells; Small Molecule Libraries; Structure-Activity Relationship | 2013 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Frequency-dependent depression of Vmax in K(+)-depolarized guinea pig papillary muscle by tetrandrine.
Topics: Action Potentials; Alkaloids; Animals; Benzylisoquinolines; Calcium Channel Blockers; Diltiazem; Electrophysiology; Female; Guinea Pigs; Male; Nitrendipine; Papillary Muscles; Verapamil | 1992 |
Polyamines allosterically modulate [3H]nitrendipine binding to the voltage-sensitive calcium channel in rat brain.
Topics: Allosteric Regulation; Animals; Calcium Channels; Cerebral Cortex; Diltiazem; In Vitro Techniques; Male; Nitrendipine; Polyamines; Rats; Rats, Inbred Strains; Tritium | 1992 |
Effects of the calcium antagonists diltiazem, verapamil and nitrendipine on the contractile responses of guinea-pig isolated ileum to electrical stimulation or carbachol.
Topics: Animals; Carbachol; Diltiazem; Electric Stimulation; Enkephalin, Methionine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nitrendipine; Potassium Chloride; Verapamil | 1992 |
The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Brain; Calcium Channels; Diltiazem; Drug Interactions; Guinea Pigs; Heart; Nitrendipine; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P; Tritium; Verapamil | 1992 |
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil | 1992 |
Effects of calcium channel blockers on formalin-induced nociception and inflammation in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Diltiazem; Formaldehyde; Hindlimb; Inflammation; Male; Nicardipine; Nitrendipine; Pain; Pain Measurement; Rats; Verapamil | 1992 |
Interactions of calmodulin antagonists with calcium antagonists binding sites.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Aorta, Thoracic; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Calmodulin; Diltiazem; Enzyme Activation; Female; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Rats; Rats, Inbred Strains; Tritium | 1991 |
Bay K 8644, modifier of calcium transport and energy metabolism in rat heart mitochondria: a new intracellular site of action.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Diphosphate; Animals; Biological Transport, Active; Calcium; Diltiazem; Energy Metabolism; Female; Glutamates; In Vitro Techniques; Malates; Mitochondria, Heart; NAD; Nitrendipine; Oxidation-Reduction; Oxygen Consumption; Rats; Ruthenium Red; Verapamil | 1990 |
Separate [3H]-nitrendipine binding sites in mitochondria and plasma membranes of bovine adrenal medulla.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Calcium Channels; Cattle; Cell Membrane; Chromaffin System; Diltiazem; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Mitochondria; Nitrendipine; Receptors, Nicotinic; Stereoisomerism; Subcellular Fractions; Verapamil | 1990 |
The hemodynamic effects of lacidipine in anesthetized dogs: comparison with nitrendipine, amlodipine, verapamil, and diltiazem.
Topics: Amlodipine; Anesthesia; Animals; Blood Gas Analysis; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Nifedipine; Nitrendipine; Stroke Volume; Vascular Resistance; Verapamil | 1991 |
Effect of strontium on action potential repolarization in rabbit sinoatrial node cells.
Topics: Action Potentials; Animals; Calcium; Cells, Cultured; Diltiazem; In Vitro Techniques; Magnesium; Manganese; Nitrendipine; Rabbits; Sinoatrial Node; Strontium | 1992 |
In vitro effects of two novel calcium antagonists (nitrendipine and nisoldipine) on intraplatelet calcium redistribution, platelet aggregation and thromboxane A2 formation. Comparison with diltiazem, nifedipine and verapamil.
Topics: Adult; Blood Platelets; Calcium; Calcium Channel Blockers; Diltiazem; Female; Humans; In Vitro Techniques; Male; Nifedipine; Nisoldipine; Nitrendipine; Platelet Aggregation; Thromboxane A2; Thromboxane B2; Verapamil | 1991 |
Experience with calcium antagonists nitrendipine, diltiazem, and verapamil and beta 2-agonist salbutamol in salvaging ischemic skin flaps in rabbits.
Topics: Albuterol; Animals; Calcium Channel Blockers; Diltiazem; Injections, Intravenous; Ischemia; Necrosis; Nitrendipine; Rabbits; Reperfusion; Skin; Surgical Flaps; Verapamil | 1991 |
Direct measurement of intracellular free calcium in cultured human puerperal myometrial cells stimulated by oxytocin: effects of extracellular calcium and calcium channel blockers.
Topics: Calcium; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Microscopy, Fluorescence; Myometrium; Nicardipine; Nifedipine; Nitrendipine; Oxytocin; Postpartum Period | 1991 |
Binding characteristics of a new 1,5-benzothiazepine, clentiazem, to rat cerebral cortex and skeletal muscle membranes.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Cerebral Cortex; Diltiazem; Male; Membranes; Muscles; Nitrendipine; Radioligand Assay; Rats; Rats, Inbred Strains; Stereoisomerism; Tritium | 1991 |
Different negative inotropic activity of Ca2(+)-antagonists in human myocardial tissue.
Topics: Calcium Channel Blockers; Depression, Chemical; Diltiazem; Heart Atria; Heart Failure; Heart Transplantation; Humans; Isradipine; Myocardial Contraction; Nifedipine; Nitrendipine; Papillary Muscles; Pyridines; Verapamil | 1990 |
[3H]-nitrendipine binding in normal and cardiomyopathic hamster hearts: modulation by temperature, verapamil and diltiazem.
Topics: Allosteric Regulation; Animals; Binding Sites; Calcium Channels; Cardiomyopathies; Cricetinae; Dihydropyridines; Diltiazem; In Vitro Techniques; Kinetics; Male; Myocardium; Nitrendipine; Temperature; Verapamil | 1990 |
Uptake of catamphiphilic drugs into erythrocytes and muscular tissue correlates to membrane enrichment and to 45Ca displacement from phosphatidylserine monolayers.
Topics: Binding Sites; Calcium; Cell Membrane; Diltiazem; Erythrocytes; Flunarizine; Humans; In Vitro Techniques; Lidocaine; Muscles; Nitrendipine; Phosphatidylserines; Verapamil | 1990 |
Synthesis and pharmacological properties of azido derivatives of 1,5-benzothiazepine Ca antagonist.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Guinea Pigs; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myocardial Contraction; Nitrendipine; Rats; Rats, Inbred Strains; Regional Blood Flow | 1990 |
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
Effect of calcium antagonists on aortae isolated from normotensive and hypertensive rats: relaxation and calcium influx blockade.
Topics: Animals; Aorta; Calcium; Diltiazem; Female; Hypertension; In Vitro Techniques; Male; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Verapamil | 1990 |
[3H]diltiazem binding to calcium channel antagonists recognition sites in rat cerebral cortex.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Calcium Channels; Cerebral Cortex; Diltiazem; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Tritium | 1985 |
Characterization of [3H]-nitrendipine binding to uterine smooth muscle plasma membrane and its relevance to inhibition of calcium entry.
Topics: Animals; Binding, Competitive; Calcium; Cell Fractionation; Cell Membrane; Diethylstilbestrol; Diltiazem; Edetic Acid; Egtazic Acid; Female; Ion Channels; Muscle, Smooth; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Uterus | 1985 |
Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists.
Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Cinnarizine; Diltiazem; Flunarizine; Ion Channels; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Phenytoin; Pheochromocytoma; Potassium; Rats; Sodium; Verapamil | 1985 |
Participation of voltage-dependent calcium channels in the regulation of adrenal glomerulosa function by angiotensin II and potassium.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Binding, Competitive; Calcium; Cell Membrane; Corticosterone; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Male; Nifedipine; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Receptors, Angiotensin | 1986 |
Effect of calcium antagonist drugs on calcium currents in mammalian skeletal muscle fibers.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; In Vitro Techniques; Ion Channels; Muscles; Nifedipine; Nitrendipine; Rabbits; Verapamil | 1986 |
Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles. Characterization of diltiazem-binding sites and their interaction with dihydropyridine and aralkylamine receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Transporting ATPases; Diltiazem; Dithiothreitol; Ethylmaleimide; Female; Guinea Pigs; Hydrogen-Ion Concentration; Iodocyanopindolol; Male; Myocardium; Nifedipine; Nitrendipine; Ouabain; Pindolol; Receptors, Nicotinic; Sodium; Sodium-Potassium-Exchanging ATPase; Stereoisomerism; Temperature; Verapamil | 1986 |
Do calcium antagonists act directly on calcium channels to alter baroreceptor function?
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Nifedipine; Nimodipine; Nitrendipine; Pressoreceptors; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Influence of Mg++ on the effect of diltiazem to increase dihydropyridine binding to receptors on Ca++-channels in chick cardiac and skeletal muscle membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Chickens; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Isradipine; Magnesium; Membranes; Muscles; Myocardium; Nitrendipine; Oxadiazoles; Receptors, Nicotinic | 1986 |
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma; Cell Line; Diltiazem; Drug Resistance; Glycoproteins; Humans; Nitrendipine; Quinidine; Verapamil; Vinblastine | 1987 |
Calcium channel receptor binding studies for diltiazem and its major metabolites: functional correlation to inhibition of portal vein myogenic activity.
Topics: Allosteric Regulation; Animals; Calcium; Calcium Channels; Cerebral Cortex; Diltiazem; In Vitro Techniques; Ion Channels; Male; Muscle, Smooth, Vascular; Nitrendipine; Portal Vein; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1987 |
[3H]BAY K 8644, a 1,4-dihydropyridine Ca++ channel activator: characteristics of binding to high and low affinity sites in cardiac membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Diltiazem; Edetic Acid; Female; Heart Ventricles; Hot Temperature; Kinetics; Lipolysis; Mathematics; Membranes; Myocardium; Nitrendipine; Propylamines; Rabbits; Tiapamil Hydrochloride; Verapamil | 1987 |
Calcium antagonist properties of diclofurime isomers. II. Molecular aspects: allosteric interactions with dihydropyridine recognition sites.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Chemical Phenomena; Chemistry, Physical; Diltiazem; In Vitro Techniques; Kinetics; Male; Nitrendipine; Oximes; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Stereoisomerism; Temperature; Verapamil | 1987 |
Suppression of charge movement by calcium antagonists is not related to calcium channel block.
Topics: Animals; Calcium; Diltiazem; In Vitro Techniques; Ion Channels; Membrane Potentials; Muscles; Nitrendipine; Rana catesbeiana | 1987 |
Vascular versus myocardial selectivity of calcium antagonists studied by concentration-time-effect relations.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Felodipine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nitrendipine; Papillary Muscles; Rats; Rats, Inbred Strains; Time Factors; Verapamil | 1987 |
Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin.
Topics: Alkaloids; Animals; Benzylisoquinolines; Calcium; Diltiazem; Drugs, Chinese Herbal; Gallopamil; Ion Channels; Kinetics; Myocardium; Nitrendipine; Plants, Medicinal; Sarcolemma; Swine | 1988 |
Dihydropyridine binding sites regulate calcium influx through specific voltage-sensitive calcium channels in cerebellar granule cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Calcium Radioisotopes; Cations, Divalent; Cell Membrane; Cells, Cultured; Cerebellum; Diltiazem; Electrophysiology; Ion Channels; Neurons; Nifedipine; Nitrendipine; Potassium; Rats; Receptors, Nicotinic; Verapamil | 1988 |
Studies on the site of the interaction between alpha 1-adrenoceptors and 5-HT2 receptors in rat tail arteries.
Topics: Animals; Arteries; Binding Sites; Diltiazem; Felodipine; In Vitro Techniques; Male; Manganese; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Tail; Verapamil | 1988 |
Natriuretic activity of amlodipine, diltiazem, and nitrendipine in saline-loaded anesthetized dogs.
Topics: Amlodipine; Anesthesia; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Female; Hemodynamics; Natriuresis; Nifedipine; Nitrendipine; Sodium; Time Factors | 1988 |
Two calcium channels in basolateral membranes of rabbit ileal epithelial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Chlorides; Diltiazem; Egtazic Acid; Electric Conductivity; Epithelium; Ileum; Male; Nifedipine; Nitrendipine; Rabbits; Sodium; Verapamil | 1989 |
Parathyroid hormone-related peptide transiently increases cytosolic calcium in osteoblast-like cells: comparison with parathyroid hormone.
Topics: Animals; Calcium; Cell Line; Cytosol; Diltiazem; Egtazic Acid; Fluorescent Dyes; Indoles; Kinetics; Neoplasm Proteins; Nitrendipine; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Parathyroid Hormone-Related Protein | 1989 |
Effects of Ca++ on [3H]diltiazem binding and its allosteric interaction with dihydropyridine calcium channel binding sites in the rat cortex.
Topics: Allosteric Regulation; Animals; Binding Sites; Calcium; Calcium Channels; Cerebral Cortex; Diltiazem; In Vitro Techniques; Male; Nitrendipine; Rats; Rats, Inbred Strains; Temperature; Verapamil | 1989 |
Comparison of contractions to serotonin, carbamylcholine and prostaglandin F2 alpha in rat stomach fundus.
Topics: Animals; Carbachol; Diltiazem; Dinoprost; Gastric Fundus; Guanidines; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Nitrendipine; Nitroglycerin; Phosphatidylinositols; Pinacidil; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Electrophysiological and pharmacological evidence that peripheral type benzodiazepine receptors are coupled to calcium channels in the heart.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Action Potentials; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; Heart; Ion Channels; Isoquinolines; Male; Myocardial Contraction; Nifedipine; Nitrendipine; Receptors, GABA-A; Tetraethylammonium Compounds; Verapamil | 1985 |
Molecular approach to the calcium channel.
Topics: Animals; Benzothiazoles; Binding Sites; Brain; Calcium; Cattle; Chemical Phenomena; Chemistry; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles; Thiazoles; Verapamil | 1985 |
Endothelin: differential effects in vascular and nonvascular smooth muscle.
Topics: Animals; Diltiazem; Dose-Response Relationship, Drug; Endothelins; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Nitrendipine; Peptides; Rabbits; Rats; Rats, Inbred Strains; Trachea; Urinary Bladder | 1989 |
Variable, voltage-dependent, blocking effects of nitrendipine, verapamil, diltiazem, cinnarizine and cadmium on adrenomedullary secretion.
Topics: Adrenal Medulla; Animals; Cadmium; Calcium Channel Blockers; Catecholamines; Cats; Cinnarizine; Diltiazem; Electric Stimulation; In Vitro Techniques; Nitrendipine; Verapamil | 1989 |
Calcium and calmodulin antagonism for inhibition of uterine contractions.
Topics: Calcium; Calmodulin; Culture Techniques; Diltiazem; Felodipine; Female; Humans; Nitrendipine; Pregnancy; Uterine Contraction | 1989 |
Lactamimides: a novel chemical class of calcium antagonists with diltiazem-like properties.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Imines; In Vitro Techniques; Male; Molecular Structure; Muscle Contraction; Muscle, Smooth; Myocardium; Nitrendipine; Rats; Rats, Inbred Strains | 1989 |
Low affinity binding sites for 1,4-dihydropyridines in mitochondria and in guinea pig ventricular membranes.
Topics: Animals; Calcium Channels; Cations, Divalent; Cell Membrane; Diltiazem; Guinea Pigs; Heart Ventricles; Hot Temperature; Mitochondria; Myocardium; Nimodipine; Nitrendipine; Osmolar Concentration; Protein Denaturation; Receptors, Nicotinic; Sodium Chloride; Verapamil | 1987 |
Interactions of DPI 201-106, a novel cardiotonic agent, with cardiac calcium channels.
Topics: Animals; Calcium; Calcium Channels; Cardiotonic Agents; Cinnarizine; Diltiazem; Gallopamil; In Vitro Techniques; Membranes; Muscle Contraction; Myocardial Contraction; Myocardium; Nitrendipine; Papillary Muscles; Piperazines; Potassium; Swine | 1988 |
Influence of age on calcium entry blocking drugs in rat aorta is spasmogen-dependent.
Topics: Aging; Animals; Aorta; Calcium; Calcium Channel Blockers; Diltiazem; Drug Interactions; Felodipine; Male; Nitrendipine; Norepinephrine; Potassium; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Specific binding of [3H]d-cis-diltiazem to cardiac sarcolemma and its inhibition by calcium.
Topics: Animals; Benzazepines; Binding, Competitive; Calcium; Diltiazem; Dogs; In Vitro Techniques; Kinetics; Myocardium; Nifedipine; Nitrendipine; Sarcolemma; Stereoisomerism | 1985 |
Hemodynamic effects of calcium entry-blocking agents in normal and hypertensive rats and man.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Female; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vascular Resistance | 1985 |
Effect of neuraminidase on diltiazem-mediated alteration of nitrendipine binding in the hog coronary artery.
Topics: Animals; Benzazepines; Coronary Vessels; Diltiazem; In Vitro Techniques; Kinetics; Membranes; Muscle, Smooth, Vascular; Neuraminidase; Nifedipine; Nitrendipine; Swine | 1985 |
Effects of bepridil and diltiazem on [3H]nitrendipine binding to canine cardiac sarcolemma. Potentiation of pharmacological effects of nitrendipine by bepridil.
Topics: Animals; Benzazepines; Bepridil; Binding Sites; Binding, Competitive; Diltiazem; Dogs; Drug Synergism; In Vitro Techniques; Kinetics; Myocardial Contraction; Nifedipine; Nitrendipine; Pyrrolidines; Rats; Sarcolemma; Temperature | 1986 |
Calcium channel antagonists. Omega-conotoxin defines a new high affinity site.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Chick Embryo; Cinnarizine; Diltiazem; Flunarizine; Muscles; Nifedipine; Nitrendipine; Prenylamine; Rana pipiens; Synaptosomes; Time Factors; Verapamil | 1986 |
Enhancement of brain calcium antagonist binding by phencyclidine and related compounds.
Topics: Anesthetics, Local; Animals; Binding Sites; Brain; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Narcotics; Neurotoxins; Nifedipine; Nitrendipine; Phencyclidine; Rats; Rats, Inbred Strains | 1986 |
The effects of some slow channel blocking drugs on high affinity serotonin uptake by rat brain synaptosomes.
Topics: Animals; Bepridil; Brain; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Pyrrolidines; Rats; Rats, Inbred Strains; Serotonin; Synaptosomes; Temperature; Time Factors; Verapamil | 1986 |
Effect of nitrendipine, diltiazem, trifluoperazine and pimozide on serotonin2 (5-HT2) receptor activation in the rat uterus and jugular vein.
Topics: Animals; Benzazepines; Calcium; Cerebral Cortex; Diltiazem; Female; In Vitro Techniques; Jugular Veins; Male; Nifedipine; Nitrendipine; Pimozide; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Trifluoperazine; Uterine Contraction; Vasoconstriction | 1986 |
Effect of membrane depolarization on binding of [3H]nitrendipine to rat cardiac myocytes.
Topics: Aconitine; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Cell Survival; Diltiazem; Heart; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Myocardium; Nifedipine; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Verapamil | 1985 |
Ca2+ channel antagonist actions in bladder smooth muscle: comparative pharmacologic and [3H]nitrendipine binding studies.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Gallopamil; Guinea Pigs; In Vitro Techniques; Male; Microsomes; Muscarine; Muscle Contraction; Muscle, Smooth; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Urinary Bladder | 1985 |
Modification of cardiac sarcolemmal Na+-Ca2+ exchange by diltiazem and verapamil.
Topics: Acebutolol; Animals; Benzazepines; Ca(2+) Mg(2+)-ATPase; Calcium; Diltiazem; In Vitro Techniques; Myocardium; Nifedipine; Nitrendipine; Propranolol; Rats; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase; Verapamil | 1985 |
Ion pathways in transverse tubules. Quantification of receptors in membranes isolated from frog and rabbit skeletal muscle.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anura; Bungarotoxins; Calcium Channels; Carrier Proteins; Diltiazem; Ethylenediamines; Kinetics; Muscles; Nifedipine; Nitrendipine; Ouabain; Rabbits; Receptors, Cholinergic; Receptors, Drug; Receptors, Nicotinic; Sodium Channels; Sodium-Potassium-Exchanging ATPase; Temperature; Tetrodotoxin | 1986 |
Binding of [3H]-nitrendipine and [3H]-diltiazem to rat myocardial sarcolemma.
Topics: Animals; Diltiazem; Electron Transport Complex IV; Glucose-6-Phosphatase; In Vitro Techniques; Male; Myocardium; Nitrendipine; Rats; Rats, Inbred Strains; Sarcolemma; Sodium-Potassium-Exchanging ATPase | 1986 |
Specific binding of the calcium antagonist [3H]verapamil to membrane fractions from plants.
Topics: Binding Sites; Diltiazem; Hydrogen-Ion Concentration; Kinetics; Membranes; Nifedipine; Nitrendipine; Plants; Verapamil | 1985 |
Antihypertensive effects of intravenous administration of benidipine hydrochloride and some other calcium antagonists in conscious, spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Intravenous; Male; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Rats; Rats, Inbred SHR; Verapamil | 1988 |
Exercise-induced intermittent angina and ST-segment elevation in Prinzmetal's angina.
Topics: Angina Pectoris, Variant; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Diltiazem; Electrocardiography; Exercise Test; Felodipine; Heart Conduction System; Humans; Male; Middle Aged; Nitrendipine | 1988 |
A novel 1,4-dihydropyridine-binding site on mitochondrial membranes from guinea-pig heart, liver and kidney.
Topics: Animals; Binding Sites; Centrifugation, Density Gradient; Dihydropyridines; Diltiazem; Guinea Pigs; Intracellular Membranes; Kidney; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Nitrendipine; Osmolar Concentration; Subcellular Fractions; Verapamil | 1988 |
Calcium antagonists preferentially dilate preglomerular vessels of hydronephrotic kidney.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Hydronephrosis; Kidney Glomerulus; Nitrendipine; Rats; Rats, Inbred Strains; Time Factors; Vasodilation | 1987 |
Comparison of the effects of calcium channel blockers and antiarrhythmic drugs on digitalis-induced oscillatory afterpotentials on canine Purkinje fiber.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Digitalis; Diltiazem; Dogs; Electric Stimulation; Female; Heart Conduction System; Male; Mexiletine; Nicardipine; Nifedipine; Nitrendipine; Plants, Medicinal; Plants, Toxic; Procainamide; Propranolol; Purkinje Fibers; Verapamil | 1987 |
The use of calcium antagonists in patients with renal failure.
Topics: Calcium Channel Blockers; Diltiazem; Humans; Kidney Failure, Chronic; Nifedipine; Nitrendipine; Verapamil | 1987 |
Comparative effects of verapamil, diltiazem and felodipine during experimental digitalis-induced arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Dogs; Felodipine; Female; Male; Nitrendipine; Ouabain; Verapamil | 1987 |
A study in the rat of the renal actions of nitrendipine and diltiazem on the adrenergic regulation of calcium and sodium reabsorption.
Topics: Animals; Blood Pressure; Calcium; Diltiazem; Electric Stimulation; Kidney; Male; Nitrendipine; Rats; Rats, Inbred Strains; Renal Circulation; Sodium; Sympathetic Nervous System | 1986 |
Effects of temperature and allosteric modulators on [3H] nitrendipine binding: methods for detecting potential Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Animals; Benzothiazoles; Binding Sites; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Microsomes; Myocardium; Nifedipine; Nitrendipine; Propylamines; Temperature; Thiazoles; Tiapamil Hydrochloride; Verapamil | 1984 |
Solubilization and affinity labeling of a dihydropyridine binding site from skeletal muscle: effects of temperature and diltiazem on [3H]dihydropyridine binding to transverse tubules.
Topics: Affinity Labels; Animals; Benzazepines; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Diltiazem; Intracellular Membranes; Kinetics; Microsomes; Microtubules; Muscles; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Rabbits; Receptors, Nicotinic; Temperature | 1984 |
Properties of receptors for the Ca2+-channel blocker verapamil in transverse-tubule membranes of skeletal muscle. Stereospecificity, effect of Ca2+ and other inorganic cations, evidence for two categories of sites and effect of nucleoside triphosphates.
Topics: Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channels; Cations, Divalent; Cations, Monovalent; Diltiazem; Electrochemistry; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Muscles; Nifedipine; Nitrendipine; Nucleotides; Pyrrolidines; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1984 |
Characterization of verapamil binding sites in cardiac membrane vesicles.
Topics: Animals; Calcium Channels; Diltiazem; Heart Ventricles; Kinetics; Myocardium; Nifedipine; Nitrendipine; Receptors, Nicotinic; Sarcolemma; Swine; Verapamil | 1984 |
Dopamine antagonist effect of verapamil on isolated perfused rabbit ear artery.
Topics: Adrenergic alpha-Antagonists; Animals; Arteries; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Nifedipine; Nitrendipine; Perfusion; Rabbits; Sulpiride; Vasoconstriction; Verapamil | 1983 |
Interactions of maitotoxin with voltage-sensitive calcium channels in cultured neuronal cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Cell Line; Diltiazem; Dose-Response Relationship, Drug; Gallopamil; Ion Channels; Marine Toxins; Neurons; Nifedipine; Nitrendipine; Oxocins; Potassium | 1984 |
Calcium channel activation: a different type of drug action.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cadmium; Calcium; Calcium Channel Blockers; Cell Line; Diltiazem; Gallopamil; Glioma; Hybrid Cells; Ion Channels; Kinetics; Mice; Neuroblastoma; Nifedipine; Nitrendipine; Pyridines; Rats | 1984 |
Specific binding of [3H]nitrendipine to membranes from coronary arteries and heart in relation to pharmacological effects. Paradoxical stimulation by diltiazem.
Topics: Animals; Benzazepines; Binding Sites; Calcium; Coronary Vessels; Diltiazem; Dogs; Ion Channels; Isomerism; Kinetics; Microsomes; Myocardium; Nifedipine; Nitrendipine; Pyridines; Sarcolemma; Swine | 1982 |
Diltiazem enhancement of [3H]nitrendipine binding to calcium channel associated drug receptor sites in rat brain synaptosomes.
Topics: Allosteric Regulation; Animals; Benzazepines; Brain; Calcium; Diltiazem; In Vitro Techniques; Ion Channels; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Drug; Synaptosomes | 1982 |
Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells.
Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Cats; Diltiazem; Gallopamil; Heart; In Vitro Techniques; Ion Channels; Kinetics; Membrane Potentials; Nifedipine; Nitrendipine; Verapamil | 1983 |
Allosteric modulation by diltiazem and verapamil of [3H]nitrendipine binding to calcium channel sites in rat brain.
Topics: Allosteric Site; Animals; Benzazepines; Brain; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Ion Channels; Kinetics; Male; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Synaptosomes; Verapamil | 1983 |
Relationship of binding of a calcium channel blocker to inhibition of contraction in intact cultured embryonic chick ventricular cells.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Chick Embryo; Diltiazem; Heart; In Vitro Techniques; Ion Channels; Myocardial Contraction; Myocardium; Nifedipine; Nitrendipine; Tritium; Verapamil | 1983 |
A simple sensitive radioreceptor assay for calcium antagonist drugs.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cattle; Cell Membrane; Cerebral Cortex; Diltiazem; In Vitro Techniques; Muscles; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Prenylamine; Radioligand Assay; Receptors, Nicotinic; Verapamil | 1983 |
Diltiazem-like effect of thioridazine on the dihydropyridine binding site of the calcium channel of rat myocardial membranes.
Topics: Animals; Benzazepines; Binding, Competitive; Calcium; Calcium Channels; Cell Membrane; Diltiazem; In Vitro Techniques; Ion Channels; Male; Myocardium; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Thioridazine | 1984 |
[3H]nitrendipine binding to adrenal capsular membranes.
Topics: Adrenal Medulla; Aldosterone; Animals; Binding Sites; Binding, Competitive; Diltiazem; Kinetics; Membranes; Nifedipine; Nitrendipine; Rats; Verapamil | 1984 |
Specific high affinity binding of the calcium channel antagonist, [3H]nitrendipine, to rat liver microsomes.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Gallopamil; In Vitro Techniques; Lanthanum; Male; Microsomes, Liver; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Tritium | 1984 |
Diltiazem and nitrendipine suppress hypoxic contracture in quiescent ventricular myocardium.
Topics: Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Nifedipine; Nitrendipine; Rabbits | 1983 |
Temperature-dependent modulation of [3H]nitrendipine binding by the calcium channel antagonists verapamil and diltiazem in rat brain synaptosomes.
Topics: Animals; Benzazepines; Binding Sites; Brain; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Male; Nifedipine; Nitrendipine; Rats; Rats, Inbred Strains; Synaptosomes; Temperature; Tritium; Verapamil | 1984 |
The interaction of [3H]nitrendipine with receptors for calcium antagonists in the cerebral cortex and heart of rats.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Chloride; Cerebral Cortex; Diltiazem; Gallopamil; Kinetics; Lanthanum; Male; Myocardium; Nifedipine; Nitrendipine; Pyridines; Rats; Rats, Inbred Strains; Receptors, Drug; Verapamil | 1982 |
Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Computer Graphics; Diltiazem; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Models, Molecular; Myocardial Contraction; Nitrendipine; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Verapamil | 1995 |
Effects of diltiazem in convulsive states differ from those previously reported for dihydropyridine calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Convulsants; Diltiazem; Infusions, Intravenous; Male; Mice; Mice, Inbred Strains; Nitrendipine; Seizures | 1994 |
Effects of Ca2+ channel antagonist subtypes on mitochondrial Ca2+ transport.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenal Medulla; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Cattle; Diltiazem; Flunarizine; In Vitro Techniques; Mitochondria; Nitrendipine; Verapamil | 1995 |
Calcium antagonist radioprotectors do not reduce radiotherapeutic efficacy in three human tumor xenografts.
Topics: Adenocarcinoma; Animals; Calcium Channel Blockers; Colonic Neoplasms; Diltiazem; Humans; Male; Mice; Mice, Inbred C3H; Mice, Nude; Neoplasm Transplantation; Nifedipine; Nimodipine; Nitrendipine; Radiation-Protective Agents; Radiotherapy Dosage; Sarcoma, Ewing; Transplantation, Heterologous; Whole-Body Irradiation | 1995 |
Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Bucladesine; Cell Differentiation; Cell Membrane; Diltiazem; Glioma; Hybrid Cells; Isradipine; Mollusk Venoms; Neuroblastoma; Nitrendipine; omega-Conotoxin GVIA; Potassium Chloride; Rats; Tumor Cells, Cultured; Verapamil | 1993 |
Pharmacological profile of UK-74,505, a novel and selective PAF antagonist with potent and prolonged oral activity.
Topics: Administration, Oral; Animals; Aorta; Azepines; Blood Platelets; Brain; Calcium Channels, L-Type; Capillary Permeability; Cattle; Dihydropyridines; Diltiazem; Gallopamil; Guinea Pigs; Hypotension; Imidazoles; In Vitro Techniques; Kinetics; Male; Membranes; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle Proteins; Nitrendipine; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Potassium Chloride; Rabbits; Rats; Rats, Sprague-Dawley; Skin; Triazoles; Tritium | 1994 |
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells, Cultured; Cholecalciferol; Cholesterol; Coronary Vessels; Diltiazem; Disease Models, Animal; Humans; Hypertension; Middle Aged; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Risk Factors; Verapamil | 1994 |
Cumulative side effects of cyclosporine and Ca antagonists: hypergalactinemia, mastadenoma, and gynecomastia.
Topics: Adenoma; Adult; Aged; Breast Neoplasms, Male; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Synergism; Female; Galactorrhea; Gynecomastia; Humans; Kidney Transplantation; Male; Middle Aged; Nifedipine; Nitrendipine | 1994 |
P-glycoprotein-mediated transcellular transport of MDR-reversing agents.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Carbon Radioisotopes; Carrier Proteins; Cell Line; Cell Line, Transformed; Dihydropyridines; Diltiazem; Drug Resistance; Epithelium; Humans; Kinetics; Membrane Glycoproteins; Nitrendipine; Protein Kinase C; Staurosporine; Sucrose; Transfection; Tritium | 1993 |
Calciseptine binding to a 1,4-dihydropyridine recognition site of the L-type calcium channel of rat synaptosomal membranes.
Topics: Animals; Brain; Calcium Channel Blockers; Calcium Channels; Cell Fractionation; Dihydropyridines; Diltiazem; Elapid Venoms; Intracellular Membranes; Kinetics; Ligands; Male; Nitrendipine; omega-Conotoxins; Peptides; Rats; Rats, Wistar; Synaptosomes; Verapamil | 1993 |
Radioprotective effects of calcium antagonists used alone or with other types of radioprotectors.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Diltiazem; Dimethyl Sulfoxide; Drug Combinations; Female; Flunarizine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Radiation-Protective Agents; Verapamil; Zinc | 1993 |
Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Antioxidants; Calcium Channel Blockers; Cell Membrane; Dihydropyridines; Diltiazem; Felodipine; Fumarates; Heart; Iron; Lipid Peroxidation; Male; Myocardium; Nicardipine; Nifedipine; Nisoldipine; Nitrendipine; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Verapamil | 1996 |
Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model.
Topics: Animals; Calcium Channel Blockers; Cerebral Cortex; Diltiazem; Models, Molecular; Nitrendipine; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazines | 1997 |
L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluorescent Dyes; Isomerism; Isradipine; Kinetics; Nicotinic Acids; Nifedipine; Nitrendipine; Oxadiazoles; Rabbits | 1997 |
Acetylcholine triggers L-glutamate exocytosis via nicotinic receptors and inhibits melatonin synthesis in rat pinealocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Arylamine N-Acetyltransferase; Atropine; Bungarotoxins; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carbachol; Cells, Cultured; Diltiazem; Exocytosis; Glutamic Acid; Melatonin; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nifedipine; Nitrendipine; Oxotremorine; Parasympathetic Nervous System; Pineal Gland; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Synaptic Vesicles; Tubocurarine | 1998 |
Functional interaction between benzothiazepine- and dihydropyridine binding sites of cardiac L-type Ca2+ channels.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Line; Dihydropyridines; Diltiazem; Membrane Potentials; Myocardium; Nitrendipine; Patch-Clamp Techniques; Temperature; Thiazepines; Time Factors | 1998 |
L-type calcium channels contribute to the tottering mouse dystonic episodes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Dystonia; Mice; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mutation; Nitrendipine; RNA, Messenger; Seizures | 1999 |
Betaxolol, a beta1-adrenoceptor antagonist, has an affinity for L-type Ca2+ channels.
Topics: Adrenergic beta-Antagonists; Animals; Betaxolol; Binding, Competitive; Calcium Channels; Carteolol; Cerebral Cortex; Diltiazem; Dose-Response Relationship, Drug; Female; Male; Membranes; Nitrendipine; Propranolol; Radioligand Assay; Rats; Rats, Wistar; Stereoisomerism; Timolol; Tritium | 1999 |
L-cis diltiazem attenuates intracellular Ca(2+) overload by metabolic inhibition in guinea pig myocytes.
Topics: Animals; Calcium; Calcium Channel Blockers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Size; Diltiazem; Dose-Response Relationship, Drug; Energy Metabolism; Guinea Pigs; Heart Ventricles; Male; Nicardipine; Nickel; Nitrendipine; Sodium-Calcium Exchanger; Stereoisomerism; Thiourea; Uncoupling Agents | 1999 |
Calcium channel activation and self-biting in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aggression; Animals; Behavior, Animal; Bites and Stings; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; Ion Channel Gating; Mice; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Pyrroles; Self-Injurious Behavior | 1999 |
Mechanism of vascular relaxation by thaligrisine: functional and binding assays.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Aorta, Thoracic; Arteries; Binding Sites; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Diltiazem; Female; In Vitro Techniques; Membranes; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrendipine; Norepinephrine; Potassium Chloride; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tail; Trees; Tritium; Vasoconstrictor Agents | 2000 |
Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic Nucleotide Phosphodiesterases, Type 4; Diltiazem; Female; Half-Life; In Vitro Techniques; Kinetics; Membranes; Nitrendipine; Papaverine; Parasympatholytics; Phosphodiesterase Inhibitors; Pregnancy; Pregnancy, Animal; Radioligand Assay; Rats; Rats, Sprague-Dawley; Uterus | 2002 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Benzamides; Brain Neoplasms; Bridged Bicyclo Compounds; Calcium Channel Blockers; Calcium Signaling; Calcium-Transporting ATPases; Cell Line, Tumor; Data Interpretation, Statistical; Diltiazem; Electrophysiology; Endoplasmic Reticulum; Humans; Neuroblastoma; Nicotinic Agonists; Nitrendipine; Patch-Clamp Techniques; Pyrroles; Receptors, Nicotinic; Sulfonamides | 2010 |
Evaluation of the inhibitory effects of antihypertensive drugs on human carboxylesterase in vitro.
Topics: Antihypertensive Agents; Benzimidazoles; Benzoates; Carboxylesterase; Diltiazem; Drug Interactions; Humans; Imidazolidines; Liver; Nitrendipine; Telmisartan; Verapamil | 2013 |