diltiazem has been researched along with nicotine in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.71) | 18.7374 |
| 1990's | 5 (14.29) | 18.2507 |
| 2000's | 19 (54.29) | 29.6817 |
| 2010's | 9 (25.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Keserü, GM | 1 |
| Caron, G; Ermondi, G | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Banfield, C; Bialer, M; Gonzalez, MA; McLean, AM; Ruggirello, DA | 1 |
| Izumi, F; Kobayashi, H; Toyohira, Y; Wada, A; Yanagihara, N; Yashima, N | 1 |
| Bing, RJ; Metz, MZ; Ohashi, M; Sato, M | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Sullivan, JP | 1 |
| Czirfuzs, A; Fleckenstein-Grün, G; Frey, M; Matyas, S; Thimm, F | 1 |
| Eto, K; Furuno, K; Gomita, Y; Matsuka, N; Oishi, R | 1 |
| Koizumi, S; Moriyama, Y; Ogura, A; Yamada, H; Yamaguchi, A | 1 |
| Murakami, Y; Okada, S; Wang, M; Yokotani, K | 1 |
| Murakami, Y; Nakamura, K; Okada, S; Yokotani, K | 1 |
| Hayashida, S; Katsura, M; Ohkuma, S; Torigoe, F; Tsujimura, A | 1 |
| Corish, J; Corrigan, OI; Fitzpatrick, D; Nolan, LM | 1 |
| Haruki, A; Himi, T; Kosaka, J; Obata, M; Sekiguchi-Tonosaki, M | 1 |
| Damaj, BB; Hu, L; Martin, R; Michniak-Kohn, BB; Silva, SM | 1 |
1 review(s) available for diltiazem and nicotine
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
34 other study(ies) available for diltiazem and nicotine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de
Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Application of a variance-stabilizing transformation approach to linear regression of calibration lines.
Topics: Calibration; Chromatography, High Pressure Liquid; Diltiazem; Gallopamil; Nicotine; Nitroglycerin; Pharmaceutical Preparations; Reference Standards; Regression Analysis; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet | 1990 |
Efflux of 45Ca from bovine adrenal medulla cells in culture caused by nicotinic receptor stimulation.
Topics: Adrenal Medulla; Animals; Calcium; Calcium Radioisotopes; Carbachol; Cattle; Cells, Cultured; Diltiazem; Muscarine; Nicotine; Receptors, Nicotinic; Stimulation, Chemical | 1984 |
Inhibitory effect of a calcium antagonist (diltiazem) on aortic and coronary contractions in rabbits.
Topics: Animals; Aorta; Arteries; Benzazepines; Calcium Channel Blockers; Coronary Vessels; Depression, Chemical; Diltiazem; Dinoprost; Dinoprostone; Muscle Contraction; Muscle, Smooth, Vascular; Nicotine; Prostaglandins E; Prostaglandins F; Rabbits; Serotonin | 1982 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cadmium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Isradipine; Neuroblastoma; Neurons; Nicotine; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Receptors, Nicotinic; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1995 |
Experimental vasoprotection by calcium antagonists against calcium-mediated arteriosclerotic alterations.
Topics: Adult; Aged; Aged, 80 and over; Animals; Arteriosclerosis; Calcium; Calcium Channel Blockers; Cells, Cultured; Cholecalciferol; Cholesterol; Coronary Vessels; Diltiazem; Disease Models, Animal; Humans; Hypertension; Middle Aged; Muscle, Smooth, Vascular; Nicotine; Nifedipine; Nitrendipine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Risk Factors; Verapamil | 1994 |
Effects of cigarette smoke inhalation on plasma diltiazem levels in rats.
Topics: Animals; Cardiovascular Agents; Diltiazem; Male; Nicotiana; Nicotine; Plants, Toxic; Rats; Rats, Wistar; Smoke; Smoking | 1997 |
Acetylcholine triggers L-glutamate exocytosis via nicotinic receptors and inhibits melatonin synthesis in rat pinealocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Arylamine N-Acetyltransferase; Atropine; Bungarotoxins; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carbachol; Cells, Cultured; Diltiazem; Exocytosis; Glutamic Acid; Melatonin; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nifedipine; Nitrendipine; Oxotremorine; Parasympathetic Nervous System; Pineal Gland; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Synaptic Vesicles; Tubocurarine | 1998 |
Nicotine-induced noradrenaline release from the isolated rat stomach by activation of L- and N-type calcium channels.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Diltiazem; Gastric Mucosa; Hexamethonium; In Vitro Techniques; Isradipine; Male; Nicotine; Norepinephrine; omega-Conotoxin GVIA; Rats; Rats, Wistar; Stomach; Tetrodotoxin | 2000 |
Nicotinic receptors involved in gastric noradrenaline release evoked by electrical stimulation of the splanchnic nerve in rats.
Topics: Animals; Atropine; Bungarotoxins; Calcium Channel Blockers; Conotoxins; Dihydro-beta-Erythroidine; Diltiazem; Electric Stimulation; Gastric Mucosa; Hexamethonium; In Vitro Techniques; Male; Mecamylamine; Nicotine; Norepinephrine; Rats; Rats, Wistar; Receptors, Nicotinic; Splanchnic Nerves; Stomach | 2001 |
Increased expression of L-type high voltage-gated calcium channel alpha1 and alpha2/delta subunits in mouse brain after chronic nicotine administration.
Topics: Analysis of Variance; Animals; Blotting, Western; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Gene Expression; Male; Mecamylamine; Mice; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Protein Subunits; Tritium; Up-Regulation | 2005 |
Combined effects of iontophoretic and chemical enhancement on drug delivery. II. Transport across human and murine skin.
Topics: Administration, Cutaneous; Albuterol; Animals; Chemistry, Pharmaceutical; Diclofenac; Diffusion; Diffusion Chambers, Culture; Diltiazem; Drug Compounding; Drug Delivery Systems; Fatty Acids; Gels; Humans; Iontophoresis; Kinetics; Lauric Acids; Liquid Crystals; Mice; Mice, Hairless; Models, Biological; Nicotine; Oleic Acid; Permeability; Pharmaceutical Preparations; Pharmaceutical Vehicles; Skin; Skin Absorption; Stearic Acids | 2007 |
Acetylcholine induces Ca2+ signaling in chicken retinal pigmented epithelial cells during dedifferentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Cell Dedifferentiation; Cell Differentiation; Cells, Cultured; Chick Embryo; Chickens; Cholinergic Agents; Diltiazem; Nicotine; Nicotinic Agonists; Receptors, Muscarinic; Receptors, Nicotinic; Retinal Pigment Epithelium | 2009 |
Transdermal and transbuccal drug delivery systems: enhancement using iontophoretic and chemical approaches.
Topics: Administration, Buccal; Administration, Cutaneous; Alanine; Animals; Azepines; Diltiazem; Drug Delivery Systems; In Vitro Techniques; Iontophoresis; Lidocaine; Mouth Mucosa; Nicotine; Skin; Skin Absorption; Sulfur Compounds; Swine | 2011 |