Page last updated: 2024-08-23

diltiazem and n-monodemethyldiltiazem

diltiazem has been researched along with n-monodemethyldiltiazem in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (25.93)	18.7374
1990's	13 (48.15)	18.2507
2000's	5 (18.52)	29.6817
2010's	2 (7.41)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dansette, PM; Fontana, E; Poli, SM	1
Dalvie, D; Loi, CM; Smith, DA	1
Finegan, BA; Hussain, MD; Tam, YK	1
Bai, SA; Lankford, S; Maskasame, C	1
Bonnefous, JL; Boulieu, R; Lahet, C	1
Derendorf, H; Lefevre, JF; Lopez, LM; Schaefer, HG; Ververs, FF	1
Ito, K; Kurosawa, N; Kurosawa, S; Owada, E; Soeda, H	1
Deeken, RA; Engle, K; Plute, KE; Shaffer, RD; Sutton, SC	1
Boucher, S; Caillé, G; Du Souich, P; Lery, L; Lery, N; Pilon, D; Spenard, J; Varin, F; Vezina, M	1
Boyd, RA; Chin, SK; Don-Pedro, O; Giacomini, KM; Sheiner, LB; Verotta, D; Williams, RL	1
Höglund, P; Nilsson, LG	4
Abernethy, DR; Mitchell, JR; Montamat, SC	1
Abernethy, DR; Montamat, SC	1
Caillé, G; du Souich, P; Homsy, W; Lefebvre, M	1
Henschel, L; Hoffmann, A; Kraul, H; Merkel, U; Sigusch, H	1
Abadi, AH; Lopez, LM; Rutledge, DR	1
Abadi, AH; Beaudreau, CA; Lopez, LM; Rutledge, DR	1
Caillé, G; du Souich, P; Homsy, W	1
Gorski, JC; Hall, SD; Hamman, MA; Jones, DR; Mayhew, BS; Rider, S	1
Aramayona, JJ; Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C	1
Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C	1
Kunze, KL; Lee, CA; Zhao, P	1
Gorski, JC; Hall, SD; Jones, DR; Quinney, SK; Zhang, X	1
Allen, KE; Babu, KN; Hanson, KL; Kunze, KL; Nelson, WL; VandenBrink, BM	1

Reviews

1 review(s) available for diltiazem and n-monodemethyldiltiazem

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005

Trials

3 trial(s) available for diltiazem and n-monodemethyldiltiazem

Article	Year
Influence of food on the bioavailability of diltiazem and two of its metabolites following the administration of conventional tablets and slow-release capsules. Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Delayed-Action Preparations; Diltiazem; Drug Administration Schedule; Food; Humans; Male; Middle Aged	1990
Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects. Die Pharmazie, 1994, Volume: 49, Issue:9 Topics: Adult; Beverages; Biological Availability; Biotransformation; Blood Pressure; Chromatography, High Pressure Liquid; Citrus; Cross-Over Studies; Diltiazem; Food-Drug Interactions; Heart Rate; Humans; Male; Spectrophotometry, Ultraviolet	1994
Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8 Topics: Administration, Oral; Adult; Biotransformation; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Intestinal Absorption; Intestines; Liver; Male; Midazolam; Models, Biological; Nonlinear Dynamics; Prospective Studies; Reproducibility of Results; Young Adult	2009

Other Studies

23 other study(ies) available for diltiazem and n-monodemethyldiltiazem

Article	Year
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
Pharmacokinetics of diltiazem in patients undergoing coronary artery bypass grafting. Therapeutic drug monitoring, 1992, Volume: 14, Issue:6 Topics: Administration, Oral; Aged; Coronary Artery Bypass; Diltiazem; Female; Humans; Male; Middle Aged; Preoperative Care	1992
The effects of chronic oral diltiazem and cimetidine dosing on the pharmacokinetics and negative dromotropic action of intravenous and oral diltiazem in the dog. Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:7 Topics: Administration, Oral; Animals; Blood Proteins; Cimetidine; Depression, Chemical; Diltiazem; Dogs; Drug Administration Schedule; Drug Interactions; Female; Infusions, Intravenous; Neural Conduction; Protein Binding	1992
Stability of diltiazem and its metabolites in human blood samples. Journal of pharmaceutical sciences, 1992, Volume: 81, Issue:4 Topics: Blood Preservation; Blood Specimen Collection; Diltiazem; Drug Stability; Humans; Temperature; Time Factors	1992
Simultaneous assay of propranolol, diltiazem and metabolites of diltiazem in human plasma by liquid chromatography. Journal of pharmaceutical and biomedical analysis, 1990, Volume: 8, Issue:6 Topics: Biotransformation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Male; Propranolol; Spectrophotometry, Ultraviolet	1990
Pharmacokinetics of diltiazem in patients with liver cirrhosis. International journal of clinical pharmacology research, 1990, Volume: 10, Issue:6 Topics: Adult; Aged; Biotransformation; Chromatography, High Pressure Liquid; Creatinine; Delayed-Action Preparations; Diltiazem; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Regression Analysis	1990
Performance of diltiazem tablet and multiparticulate osmotic formulations in the dog. Pharmaceutical research, 1990, Volume: 7, Issue:8 Topics: Absorption; Animals; Biological Availability; Diltiazem; Dogs; Solubility; Tablets	1990
The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:4 Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Diltiazem; Half-Life; Humans; Male; Protein Binding	1989
Pharmacokinetics of diltiazem and its metabolites after repeated multiple-dose treatments in healthy volunteers. Therapeutic drug monitoring, 1989, Volume: 11, Issue:5 Topics: Adult; Biotransformation; Blood Chemical Analysis; Diltiazem; Feces; Female; Half-Life; Humans; Middle Aged; Reference Values	1989
Pharmacokinetics of diltiazem and its metabolites after repeated single dosing in healthy volunteers. Therapeutic drug monitoring, 1989, Volume: 11, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Diltiazem; Female; Half-Life; Humans; Male; Middle Aged	1989
Pharmacokinetics of diltiazem and its metabolites after single and multiple dosing in healthy volunteers. Therapeutic drug monitoring, 1989, Volume: 11, Issue:5 Topics: Administration, Oral; Adult; Biotransformation; Capsules; Diltiazem; Feces; Female; Half-Life; Humans; Male; Middle Aged; Reference Values	1989
Physiological disposition of intravenously administered 14C-labeled diltiazem in healthy volunteers. Therapeutic drug monitoring, 1988, Volume: 10, Issue:4 Topics: Adult; Blood Pressure; Diltiazem; Electrocardiography; Female; Half-Life; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Scintillation Counting	1988
High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma. Journal of chromatography, 1987, Mar-20, Volume: 415, Issue:1 Topics: Aged; Biotransformation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Hypertension; Kinetics; Male; Spectrophotometry, Ultraviolet	1987
N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives. British journal of clinical pharmacology, 1987, Volume: 24, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Diltiazem; Female; Half-Life; Humans; Hypertension; Kinetics; Male	1987
Metabolism of diltiazem in hepatic and extrahepatic tissues of rabbits: in vitro studies. Pharmaceutical research, 1995, Volume: 12, Issue:4 Topics: Animals; Diltiazem; In Vitro Techniques; Intestinal Mucosa; Kidney; Liver; Male; Rabbits	1995
Liquid chromatographic determination of celiprolol, diltiazem, desmethyldiltiazem and deacetyldiltiazem in plasma using a short alkyl chain silanol deactivated column. Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:1 Topics: Celiprolol; Chromatography, High Pressure Liquid; Diltiazem; Humans; Reference Standards; Reproducibility of Results; Silanes	1994
High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column. Journal of chromatography, 1993, May-19, Volume: 615, Issue:1 Topics: Chromatography, High Pressure Liquid; Diltiazem; Humans; Hypertension; Indicators and Reagents; Male; Silanes; Spectrophotometry, Ultraviolet	1993
The site of absorption in the small intestine determines diltiazem bioavailability in the rabbit. Pharmaceutical research, 1995, Volume: 12, Issue:11 Topics: Animals; Biological Availability; Biotransformation; Blood Gas Analysis; Calcium Channel Blockers; Diltiazem; Half-Life; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Male; Rabbits	1995
Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:3 Topics: Adult; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Humans; Kinetics; Methylation; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating	1999
Diltiazem blood pharmacokinetics in the pregnant and non-pregnant rabbit: maternal and foetal tissue levels. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:8 Topics: Animals; Antihypertensive Agents; Brain; Diltiazem; Female; Fetal Blood; Fetus; Injections, Intravenous; Kidney; Kinetics; Maternal-Fetal Exchange; Muscles; Placenta; Pregnancy; Pregnancy, Animal; Regression Analysis; Tissue Distribution; Uterus	2000
Altered diltiazem metabolism in the neonatal rabbit following intra-uterine chronic exposure to diltiazem. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Chromatography, High Pressure Liquid; Diltiazem; Female; Intestinal Mucosa; Liver; Lung; Maternal Exposure; Pregnancy; Rabbits; Time Factors; Tissue Distribution	2001
Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:5 Topics: Antifungal Agents; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Humans; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Molecular Structure; Time Factors	2007
Sequential metabolism of secondary alkyl amines to metabolic-intermediate complexes: opposing roles for the secondary hydroxylamine and primary amine metabolites of desipramine, (s)-fluoxetine, and N-desmethyldiltiazem. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6 Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Desipramine; Diltiazem; Fluoxetine; Humans; Hydroxylamine; Hydroxylamines; Hydroxylation; Imipramine; Microsomes, Liver; Oxidoreductases, N-Demethylating; Steroid 16-alpha-Hydroxylase	2010