Page last updated: 2024-08-23

diltiazem and morphine

diltiazem has been researched along with morphine in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (20.51)	18.7374
1990's	12 (30.77)	18.2507
2000's	12 (30.77)	29.6817
2010's	7 (17.95)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bustamante, D; Fernandez, E; Kramer, V; Miranda, HF; Paeile, C; Pelissier, T; Pinardi, G; Saavedra, H	1
Baeyens, JM; Del Pozo, E; Ruiz-García, C	1
Leza, JC; Lizasoain, I; Martin, MI	1
Benedek, G; Hideg, J; Szikszay, M	1
Kavaliers, M; Ossenkopp, KP	1
Baeyens, JM; Barrios, M	1
Ahmed, MS; Quarles, C; Schoof, T; Zhou, DH	1
London, ED; Snyder, FR; Szikszay, M	1
Borowitz, JL; Kuta, CC; Maickel, RP	1
Benedek, G; Szikszay, M	1
Iwasaki, H; Kawamata, M; Namiki, A; Omote, K; Sonoda, H	1
Ho, IK; Tokuyama, S	2
Görgün, CZ; Güney, HZ; Güzey, C; Hodoğluğil, U; Savran, B; Zengil, H	1
Fukunaga, Y; Inoue, N; Kishioka, S; Nishida, S; Yamamoto, H	1
Contreras, E; Germany, A; Gonzalez, P; Norris, B	1
Hasegawa, AE; Zacny, JP	1
Abdollahi, M; Etemad, F; Nikfar, S; Sarkarati, F	1
Doğrul, A; Yeşilyurt, O	1
Kishioka, S; Ko, MC; Woods, JH	1
Mediratta, PK; Sharma, KK; Verma, V	1
Fan, X; Fukazawa, Y; Kishioka, S; Maeda, T; Ozaki, M; Shimizu, N; Yamamoto, H	1
Fukazawa, Y; Kishioka, S; Maeda, T; Ozaki, M; Shimizu, N; Yamamoto, C; Yamamoto, H	1

Reviews

1 review(s) available for diltiazem and morphine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for diltiazem and morphine

Article	Year
The influence of three L-type calcium channel blockers on morphine effects in healthy volunteers. Anesthesia and analgesia, 1997, Volume: 85, Issue:3 Topics: Adjuvants, Anesthesia; Adult; Affect; Analgesics, Opioid; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Double-Blind Method; Female; Humans; Male; Morphine; Nimodipine; Pain Threshold; Psychomotor Performance; Reference Values; Verapamil	1997

Article

Year

The influence of three L-type calcium channel blockers on morphine effects in healthy volunteers.

Anesthesia and analgesia, 1997, Volume: 85, Issue:3

Topics: Adjuvants, Anesthesia; Adult; Affect; Analgesics, Opioid; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Double-Blind Method; Female; Humans; Male; Morphine; Nimodipine; Pain Threshold; Psychomotor Performance; Reference Values; Verapamil

1997

Other Studies

37 other study(ies) available for diltiazem and morphine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Antinociceptive effects of Ca2+ channel blockers. European journal of pharmacology, 1992, Jul-07, Volume: 217, Issue:2-3 Topics: Analgesics; Analysis of Variance; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Mice; Morphine; Nifedipine; Nimodipine; Pain Measurement; Rats; Rats, Wistar; Verapamil	1992
Analgesic effects of diltiazem and verapamil after central and peripheral administration in the hot-plate test. General pharmacology, 1990, Volume: 21, Issue:5 Topics: Analgesics; Animals; Diltiazem; Drug Synergism; Female; Injections, Intraventricular; Injections, Subcutaneous; Mice; Morphine; Reaction Time; Verapamil	1990
Calcium channel blockers: effect on morphine-induced hypermotility. Psychopharmacology, 1990, Volume: 101, Issue:2 Topics: Animals; Calcium Channel Blockers; Dextroamphetamine; Diltiazem; Male; Mice; Morphine; Motor Activity; Nifedipine	1990
Non-opiate analgesia following stressful acoustic stimulation. Physiology & behavior, 1985, Volume: 35, Issue:1 Topics: Acoustic Stimulation; Analgesia; Animals; Diltiazem; Endorphins; Male; Morphine; Naloxone; Pain; Rats; Rats, Inbred Strains; Sincalide; Stress, Physiological; Substance P	1985
Magnetic fields inhibit opioid-mediated 'analgesic' behaviours of the terrestrial snail, Cepaea nemoralis. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 1988, Volume: 162, Issue:4 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Diltiazem; Ion Channels; Magnetics; Morphine; Naloxone; Nifedipine; Nociceptors; Pyrrolidines; Snails; Temperature; Verapamil	1988
Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro. European journal of pharmacology, 1988, Jul-26, Volume: 152, Issue:1-2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Ethanol; Female; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Rats; Rats, Inbred Strains; Stereoisomerism; Substance Withdrawal Syndrome; Verapamil	1988
Kappa opioid receptors of human placental villi modulate acetylcholine release. Life sciences, 1989, Volume: 45, Issue:25 Topics: Acetylcholine; Chorionic Villi; Diltiazem; Female; Humans; In Vitro Techniques; Kinetics; Morphine; Naloxone; Naltrexone; Pregnancy; Receptors, Opioid; Receptors, Opioid, kappa	1989
Effects of diltiazem on morphine-induced respiratory decline. The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:8 Topics: Animals; Diltiazem; Drug Interactions; Male; Morphine; Pulmonary Gas Exchange; Rats; Rats, Inbred F344; Respiration; Respiratory Physiological Phenomena; Respiratory System	1986
Modification of drug action by hyperammonemia. The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:1 Topics: Acetates; Ammonia; Amphetamine; Animals; Calcium; Cattle; Diltiazem; Drug Interactions; Guinea Pigs; Ileum; Ion Channels; Male; Mice; Morphine; Motor Activity; Muscle Contraction; Verapamil	1984
Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists. Pharmacological research communications, 1984, Volume: 16, Issue:10 Topics: Analgesics; Animals; Body Temperature Regulation; Calcium Channel Blockers; Diltiazem; Drug Synergism; Male; Morphine; Nociceptors; Rats; Rats, Inbred Strains; Verapamil	1984
Potentiation of antinociceptive effects of morphine by calcium-channel blockers at the level of the spinal cord. Anesthesiology, 1993, Volume: 79, Issue:4 Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Injections, Spinal; Male; Morphine; Nicardipine; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Verapamil	1993
Effects of diltiazem, a Ca2+ channel blocker, on naloxone-precipitated changes in dopamine and its metabolites in the brains of opioid-dependent rats. Psychopharmacology, 1996, Volume: 125, Issue:2 Topics: Animals; Brain; Butorphanol; Calcium Channel Blockers; Cerebral Cortex; Corpus Striatum; Diltiazem; Dopamine; Male; Mesencephalon; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	1996
Inhibitory effects of diltiazem, an L-type Ca2+ channel blocker, on naloxone-increased glutamate levels in the locus coeruleus of opioid-dependent rats. Brain research, 1996, May-25, Volume: 722, Issue:1-2 Topics: Animals; Butorphanol; Calcium Channel Blockers; Diltiazem; Glutamic Acid; Locus Coeruleus; Male; Microdialysis; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	1996
Temporal variation in the interaction between calcium channel blockers and morphine-induced analgesia. Chronobiology international, 1996, Volume: 13, Issue:3 Topics: Analgesia; Animals; Calcium Channel Blockers; Circadian Rhythm; Diltiazem; Drug Synergism; Male; Mice; Mice, Inbred BALB C; Morphine; Nicardipine; Pain; Verapamil	1996
Diltiazem inhibits naloxone-precipitated and spontaneous morphine withdrawal in rats. European journal of pharmacology, 1996, Nov-28, Volume: 316, Issue:1 Topics: Animals; Body Weight; Calcium Channel Blockers; Corticosterone; Diarrhea; Diltiazem; Drug Interactions; Male; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	1996
Influence of opiate tolerance and calcium channel antagonists on the antinociceptive effects of L-arginine and NG-nitro L-arginine. General pharmacology, 1997, Volume: 28, Issue:3 Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Calcium Channel Blockers; Diltiazem; Drug Tolerance; Enzyme Inhibitors; Male; Mice; Morphine; Nitric Oxide Synthase; Nitroarginine; Pain Measurement; Pentazocine; Verapamil	1997
Interaction between calcium channel blockers and sweetening agents on morphine-induced analgesia in mice by formalin test. General pharmacology, 1998, Volume: 31, Issue:3 Topics: Analgesics; Animals; Aspartame; Calcium Channel Blockers; Diltiazem; Drug Interactions; Male; Mice; Morphine; Nifedipine; Pain Measurement; Saccharin; Sucrose; Sweetening Agents; Verapamil	1998
Effects of Ca2+ channel blockers on apomorphine, bromocriptine and morphine-induced locomotor activity in mice. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: Amlodipine; Animals; Apomorphine; Benzazepines; Bromocriptine; Calcium Channel Blockers; Diltiazem; Dopamine Antagonists; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Mice; Morphine; Motor Activity; Nicardipine; Time Factors; Verapamil	1999
Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys. European journal of pharmacology, 2000, May-26, Volume: 397, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzimidazoles; Calcium Channel Blockers; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Female; Fentanyl; Heroin; Macaca mulatta; Male; Morphine; Nalbuphine; Pain Measurement; Receptors, Opioid; Respiration; Time Factors	2000
Potentiation of analgesia and reversal of tolerance to morphine by calcium channel blockers. Indian journal of experimental biology, 2001, Volume: 39, Issue:7 Topics: Analgesia; Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Drug Tolerance; Female; Flunarizine; Male; Mice; Morphine; Nimodipine; Pain Threshold; Verapamil	2001
Effects of diltiazem and MK-801 on morphine analgesia and pharmacokinetics in mice. Neuroscience letters, 2002, Jul-05, Volume: 326, Issue:3 Topics: Analgesia; Animals; Brain; Calcium Channel Blockers; Diltiazem; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Mice; Mice, Inbred ICR; Morphine; Receptors, N-Methyl-D-Aspartate	2002
Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice. Journal of pharmacological sciences, 2004, Volume: 94, Issue:3 Topics: Analgesia; Animals; Area Under Curve; Brain; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Nimodipine; Pain; Pain Measurement; Physical Stimulation; Tissue Distribution; Verapamil	2004