Page last updated: 2024-08-23

diltiazem and midazolam

diltiazem has been researched along with midazolam in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (11.11)	18.2507
2000's	19 (52.78)	29.6817
2010's	13 (36.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Coassolo, P; Lavé, T; Schneider, G	1
Topliss, JG; Yoshida, F	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Kanebratt, KP; Sjögren, E; Svanberg, P	1
Dalvie, D; Loi, CM; Smith, DA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chaptal, PA; Colson, P; Cuchet, D; Grolleau, D; Médioni, P; Roquefeuil, B; Saussine, M; Séguin, JR	1
Aranko, K; Backman, JT; Himberg, JJ; Neuvonen, PJ; Olkkola, KT	1
Ahonen, J; Hynynen, M; Neuvonen, PJ; Olkkola, KT; Salmenperä, M	1
Iga, T; Kotaki, H; Matsuo, H; Sawada, Y; Takedomi, S; Yamamoto, K; Yamano, K	1
Cantrell, VE; Eckstein, J; Hall, SD; Hamman, MA; Jones, DR; Ring, BJ; Ruterbories, K; Williams, JA; Wrighton, SA	1
Grimm, SW; Hall, SD; Jones, DR; Wang, YH; Zhao, XJ	1
Hayashi, M; Nakamura, K; Sako, K; Sawada, T; Yokohama, S; Yoshihara, K	1
Kohno, Y; Suzuki, A; Yamamoto, T	1
Baba, T; Kanazu, T; Koike, M; Okamura, N; Yamaguchi, Y	1
Honda, G; Ishizaki, T; Iwano, S; Kamataki, T; Kiyotani, K; Matsumura, K; Nakagawa, K; Yamaori, S; Yamazaki, H	1
Kapelyukh, Y; Maréchal, JD; Paine, MJ; Roberts, GC; Sutcliffe, MJ; Wolf, CR	1
Gorski, JC; Hall, SD; Jones, DR; Quinney, SK; Zhang, X	1
Bergman, AJ; Chodakewitz, J; Fraser, IP; Friedman, EJ; Larson, PJ; Li, CC; Stoch, SA; Wagner, JA; Wang, YH	1
Hara, T; Harioka, T; Ishiyama, T; Kimura, Y; Matsukawa, T; Nakasato, A; Okamura, M	1
Houjo, T; Ishigai, M; Kato, M; Ogawa, K	1
Bhutani, P; Haarhoff, ZE; Kramer, MA; Rodrigues, AD; Subramanian, M; Zhang, J; Zvyaga, TA	1

Reviews

1 review(s) available for diltiazem and midazolam

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

5 trial(s) available for diltiazem and midazolam

Article	Year
Hemodynamic effect of calcium channel blockade during anesthesia for coronary artery surgery. Journal of cardiothoracic and vascular anesthesia, 1992, Volume: 6, Issue:4 Topics: Anesthesia, Intravenous; Blood Pressure; Cardiac Output; Cardiopulmonary Bypass; Coronary Artery Bypass; Coronary Disease; Diltiazem; Double-Blind Method; Droperidol; Fentanyl; Flunitrazepam; Heart Rate; Hemodynamics; Humans; Incidence; Intraoperative Complications; Midazolam; Middle Aged; Placebos; Pulmonary Wedge Pressure; Time Factors; Vascular Resistance	1992
Dose of midazolam should be reduced during diltiazem and verapamil treatments. British journal of clinical pharmacology, 1994, Volume: 37, Issue:3 Topics: Administration, Oral; Adult; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Midazolam; Psychomotor Performance; Verapamil	1994
Effect of diltiazem on midazolam and alfentanil disposition in patients undergoing coronary artery bypass grafting. Anesthesiology, 1996, Volume: 85, Issue:6 Topics: Adjuvants, Anesthesia; Alfentanil; Anesthesia Recovery Period; Anesthetics, Intravenous; Area Under Curve; Calcium Channel Blockers; Coronary Artery Bypass; Diltiazem; Double-Blind Method; Drug Interactions; Female; Humans; Male; Midazolam; Middle Aged	1996
Semiphysiologically based pharmacokinetic models for the inhibition of midazolam clearance by diltiazem and its major metabolite. Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:8 Topics: Administration, Oral; Adult; Biotransformation; Computer Simulation; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Enzyme Inhibitors; Female; Humans; Infusions, Intravenous; Intestinal Absorption; Intestines; Liver; Male; Midazolam; Models, Biological; Nonlinear Dynamics; Prospective Studies; Reproducibility of Results; Young Adult	2009
Effect of different durations and formulations of diltiazem on the single-dose pharmacokinetics of midazolam: how long do we go? Journal of clinical pharmacology, 2011, Volume: 51, Issue:11 Topics: Adult; Area Under Curve; Chemistry, Pharmaceutical; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Female; Humans; Ketoconazole; Male; Midazolam; Middle Aged; Sensitivity and Specificity; Young Adult	2011

Other Studies

30 other study(ies) available for diltiazem and midazolam

Article	Year
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results	2006
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Optimized experimental design for the estimation of enzyme kinetic parameters: an experimental evaluation. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Chromatography, Liquid; Cytochrome P-450 Enzyme System; Humans; Kinetics; Microsomes, Liver; Research Design; Tandem Mass Spectrometry	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Quantitative prediction of metabolic inhibition of midazolam by erythromycin, diltiazem, and verapamil in rats: implication of concentrative uptake of inhibitors into liver. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:3 Topics: Animals; Blood Proteins; Diltiazem; Drug Interactions; Erythromycin; Hypnotics and Sedatives; Liver; Male; Midazolam; Protein Binding; Rats; Rats, Sprague-Dawley; Verapamil	2000
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:8 Topics: Alprazolam; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clarithromycin; Coumarins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochromes b5; Diltiazem; Estradiol; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Midazolam; Nifedipine; Tamoxifen; Testosterone; Triazolam	2002
Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites. Xenobiotica; the fate of foreign compounds in biological systems, 2002, Volume: 32, Issue:10 Topics: Antineoplastic Agents, Hormonal; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Diltiazem; DNA, Complementary; Dose-Response Relationship, Drug; GABA Modulators; Humans; Kinetics; Liver; Microsomes, Liver; Midazolam; Oxazines; Oxidoreductases, N-Demethylating; Tamoxifen; Testosterone; Time Factors	2002
Timed-release formulation to avoid drug-drug interaction between diltiazem and midazolam. Journal of pharmaceutical sciences, 2003, Volume: 92, Issue:4 Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Area Under Curve; Calcium Channel Blockers; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Diltiazem; Dogs; Drug Compounding; Drug Interactions; In Vitro Techniques; Male; Midazolam; Pharmaceutical Solutions; Solubility; Tablets; Time Factors	2003
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:1 Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil	2004
Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:5 Topics: Administration, Oral; Animals; Antibodies; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Enzyme Inhibitors; Erythromycin; Female; Humans; In Vitro Techniques; Ketoconazole; Kinetics; Macaca fascicularis; Microsomes, Liver; Midazolam; Models, Animal; Oxidoreductases, N-Demethylating	2004
CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects. Drug metabolism and pharmacokinetics, 2004, Volume: 19, Issue:2 Topics: Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Diltiazem; DNA; DNA Primers; Escherichia coli; GABA Modulators; Genotype; Humans; Hydroxylation; In Vitro Techniques; Japan; Kinetics; Microsomes, Liver; Midazolam; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Pharmaceutical Preparations; Reverse Transcriptase Polymerase Chain Reaction; Testosterone	2004
Multiple substrate binding by cytochrome P450 3A4: estimation of the number of bound substrate molecules. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:10 Topics: Catalytic Domain; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Diltiazem; Humans; Kinetics; Midazolam; Models, Molecular; Spectrophotometry, Ultraviolet; Substrate Specificity	2008
[Suspected diltiazem intoxication resulting in repeated asystole after the induction of anesthesia]. Masui. The Japanese journal of anesthesiology, 2012, Volume: 61, Issue:1 Topics: Adult; Anesthesia; Diltiazem; Drug Interactions; Embolization, Therapeutic; Heart Arrest; Humans; Intracranial Aneurysm; Male; Midazolam; Nicardipine; Perioperative Care; Subarachnoid Hemorrhage	2012
A new approach to predicting human hepatic clearance of CYP3A4 substrates using monkey pharmacokinetic data. Xenobiotica; the fate of foreign compounds in biological systems, 2013, Volume: 43, Issue:5 Topics: Alprazolam; Animals; Cytochrome P-450 CYP3A; Diltiazem; Humans; Liver; Macaca fascicularis; Midazolam; Tacrolimus	2013
Comprehensive evaluation of liver microsomal cytochrome P450 3A (CYP3A) inhibition: comparison of cynomolgus monkey and human. Xenobiotica; the fate of foreign compounds in biological systems, 2017, Volume: 47, Issue:6 Topics: Animals; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Humans; Kinetics; Macaca fascicularis; Microsomes, Liver; Midazolam; Models, Biological	2017