Page last updated: 2024-08-23

diltiazem and mibefradil

diltiazem has been researched along with mibefradil in 60 studies

Research

Studies (60)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	26 (43.33)	18.2507
2000's	26 (43.33)	29.6817
2010's	8 (13.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Coassolo, P; Lavé, T; Schneider, G	1
Topliss, JG; Yoshida, F	1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Keserü, GM	1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Dansette, PM; Fontana, E; Poli, SM	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Caron, G; Ermondi, G; Visentin, S	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ballard, TE; Henderson, JL; Kalgutkar, AS; Obach, RS; Orr, ST; Ripp, SL; Scott, DO; Sun, H	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Billman, GE	1
Clozel, JP; Hess, P; Véniant, M; Wolfgang, R	2
Blaheta, RA; Encke, A; Hailer, NP; Harder, S; Markus, BH; Scholz, M	1
Carayon, A; Crozatier, B; Hittinger, L; Renaud, N; Su, J	1
Hermsmeyer, K; Mishra, SK	1
Billman, GE; Hamlin, RL	1
Chrysant, SG; Jain, A; Korrin, I; Massie, BM; Weir, M; Weiss, R	1
Kobrin, I; Lacourcière, Y; Massie, BM; Viskoper, R; Woittiez, A	1
Davies, GJ; Kobrin, I; Tzivoni, D	1
Armagnijan, D; Caspi, A; Coelho, OR; Davies, GJ; de Albuquerque, DC; Kobrin, I; Reisin, LH; Schneeweiss, A	1
Pitt, B	1
Kobrin, I	1
Conlin, PR; Williams, GH	1
Lüscher, TF; Noll, G	1
Bieska, G; Charlon, V; Kobrin, I; Lindberg, E; Pordy, R	1
Borzak, S; Goldstein, S; Sabbah, HN; Shimoyama, H; Tanimura, M	1
Massie, BM	1
Brixius, K; Hoischen, S; Schwinger, RH	1
Brixius, K; Hoischen, S; Mohr, V; Müller-Ehmsen, J; Münch, G; Schwinger, RH	1
Cleophas, TJ; Daniëls, MC; Hendriks, MG; Holwerda, NJ; Schelling, A; Van Der Vring, JA; Withagen, PJ	2
Chen, H; Daloze, P; Dumont, L; Lapointe, N; Qi, S; Xu, D	1
Cleophas, TJ; Daniëls, MC; Hendriks, MG; Holwerda, KJ; Schelling, A; van der Sluijs, J; van der Vring, JA; Withagen, AJ; Zwinderman, AH	1
Bénardeau, A; Ertel, EA; Hondeghem, L; Weissenburger, J	1
Göthert, M; Likungu, J; Molderings, GJ	1
Backman, JT; Kivistö, KT; Neuvonen, PJ; Varis, T	1
Ceric, F; Kerr, B; Kong, M; Morales, P; Pizarro, E; Vigil, P	1
Avdonin, PV; Buhler, FR; Tkachuk, VA	1
Ahn, JS; Cho, KW; Cui, X; Kim, SH; Kim, SZ; Lee, HS; Park, YK; Seul, KH; Wen, JF	1
Bénardeau, A; Fareh, S; Nattel, S	1
Duggan, JA; Tabrizchi, R	1
Thadani, U	1
Dean, DM; Gervais, PB; Goodman, S; Langer, A; Lee, DS; Lenis, J; Ma, P	1
Horinouchi, T; Imai, T; Koike, K; Okamoto, T; Shigenobu, K; Tanaka, H; Tanaka, Y; Yamamoto, Y	1
Feng, MG; Li, M; Navar, LG	1
Savoia, C; Schiffrin, EL; Tabet, F; Touyz, RM	1
Brunette, MG; Couchourel, D; Filep, J; Leclerc, M	1
Cool, C; Cribbs, L; Fagan, K; Fouty, B; Harral, J; Hoedt-Miller, M; Li, KX; Reese, K; Rodman, DM; Tada, Y; West, J; Wu, S	1
Badawi, JK; Bross, S; Kamp, S; Kwon, ST; Langbein, S; Li, H	1
Lee, S; Roizes, S; von der Weid, PY	1

Reviews

7 review(s) available for diltiazem and mibefradil

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks. Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11 Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Drug Interactions; Heme; Humans; Models, Biological; Pharmacokinetics; Structure-Activity Relationship; Time Factors	2012
Diversity of calcium antagonists. Clinical therapeutics, 1997, Volume: 19 Suppl A Topics: Angina Pectoris; Arteriosclerosis; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Kidney Failure, Chronic; Mibefradil; Nifedipine; Tetrahydronaphthalenes; Verapamil	1997
Use of calcium channel blockers in hypertension. Advances in internal medicine, 1998, Volume: 43 Topics: Antihypertensive Agents; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Case-Control Studies; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Heart Diseases; Humans; Hypertension; Longitudinal Studies; Mibefradil; Nifedipine; Public Health; Randomized Controlled Trials as Topic; Risk Factors; Tetrahydronaphthalenes; Vasodilator Agents; Verapamil	1998
Comparative pharmacological properties among calcium channel blockers: T-channel versus L-channel blockade. Cardiology, 1998, Volume: 89 Suppl 1 Topics: Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Electrocardiography; Hemodynamics; Humans; Mibefradil; Tetrahydronaphthalenes; Verapamil	1998
Anti-anginal and anti-ischemic effects of mibefradil, a new T-type calcium channel antagonist. Cardiology, 1998, Volume: 89 Suppl 1 Topics: Adolescent; Adult; Amlodipine; Angina Pectoris; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Male; Mibefradil; Middle Aged; Myocardial Ischemia; Safety; Tetrahydronaphthalenes	1998
Mibefradil, a T-type channel-selective calcium antagonist: clinical trials in chronic stable angina pectoris. American journal of hypertension, 1998, Volume: 11, Issue:4 Pt 3 Topics: Amlodipine; Angina Pectoris; Benzimidazoles; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Humans; Mibefradil; Tetrahydronaphthalenes	1998

Trials

11 trial(s) available for diltiazem and mibefradil

Article	Year
Antihypertensive effects of mibefradil: a double-blind comparison with diltiazem CD. Clinical cardiology, 1997, Volume: 20, Issue:6 Topics: Adult; Aged; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Female; Humans; Hypertension; Linear Models; Male; Mibefradil; Middle Aged; Multivariate Analysis; Tetrahydronaphthalenes	1997
Mibefradil in the treatment of systemic hypertension: comparative studies with other calcium antagonists. The American journal of cardiology, 1997, Aug-21, Volume: 80, Issue:4B Topics: Adult; Aged; Amlodipine; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Edema; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Leg; Male; Mibefradil; Middle Aged; Nifedipine; Tetrahydronaphthalenes	1997
Mibefradil in the treatment of chronic stable angina pectoris: comparative studies with other calcium antagonists. The American journal of cardiology, 1997, Aug-21, Volume: 80, Issue:4B Topics: Adult; Aged; Aged, 80 and over; Amlodipine; Angina Pectoris; Benzimidazoles; Calcium Channel Blockers; Chronic Disease; Diltiazem; Female; Hemodynamics; Humans; Male; Mibefradil; Middle Aged; Nitroglycerin; Tetrahydronaphthalenes	1997
Long-term antianginal and antiischemic effects of mibefradil, the novel T-type calcium channel blocker: a multicenter, double-blind, placebo-controlled, randomized comparison with sustained-release diltiazem. American heart journal, 1997, Volume: 134, Issue:2 Pt 1 Topics: Adult; Aged; Angina Pectoris; Benzimidazoles; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Exercise Test; Female; Hemodynamics; Humans; Male; Mibefradil; Middle Aged; Nitroglycerin; Prospective Studies; Tetrahydronaphthalenes	1997
Differential properties of mibefradil in hypertension and angina. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1997, Volume: 15, Issue:5 Topics: Angina Pectoris; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Heart Rate; Humans; Hypertension; Mibefradil; Nifedipine; Tetrahydronaphthalenes	1997
Anti-anginal and anti-ischemic effects of mibefradil, a new T-type calcium channel antagonist. Cardiology, 1998, Volume: 89 Suppl 1 Topics: Adolescent; Adult; Amlodipine; Angina Pectoris; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Male; Mibefradil; Middle Aged; Myocardial Ischemia; Safety; Tetrahydronaphthalenes	1998
Combination of calcium channel blockers and beta-adrenoceptor blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. Netherlands Working Group on Cardiovascul British journal of clinical pharmacology, 1999, Volume: 47, Issue:5 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angina Pectoris; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dizziness; Double-Blind Method; Drug Therapy, Combination; Exercise; Exercise Test; Female; Heart Rate; Hemodynamics; Humans; Male; Mibefradil; Middle Aged; Risk Assessment; Tetrahydronaphthalenes	1999
Combination of calcium channel blockers and beta blockers for patients with exercise-induced angina pectoris: a double-blind parallel-group comparison of different classes of calcium channel blockers. The Netherlands Working Group on Cardiovascular Resear Angiology, 1999, Volume: 50, Issue:6 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angina Pectoris; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dizziness; Double-Blind Method; Drug Combinations; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Male; Mibefradil; Middle Aged; Myocardial Ischemia; Physical Exertion; Tetrahydronaphthalenes; Time Factors	1999
Combination of calcium channel blockers and beta-blockers for patients with exercise-induced angina pectoris: beneficial effect of calcium channel blockers largely determined by their effect on heart rate. Journal of clinical pharmacology, 1999, Volume: 39, Issue:7 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angina Pectoris; Benzimidazoles; Calcium Channel Blockers; Death, Sudden; Diltiazem; Dizziness; Double-Blind Method; Drug Therapy, Combination; Exercise; Exercise Test; Female; Heart Rate; Humans; Male; Mibefradil; Middle Aged; Regression Analysis; Tetrahydronaphthalenes; Treatment Outcome	1999
Diltiazem and mibefradil increase the plasma concentrations and greatly enhance the adrenal-suppressant effect of oral methylprednisolone. Clinical pharmacology and therapeutics, 2000, Volume: 67, Issue:3 Topics: Adrenal Glands; Adult; Anti-Inflammatory Agents; Antihypertensive Agents; Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Diltiazem; Double-Blind Method; Drug Synergism; Female; Humans; Hydrocortisone; Male; Methylprednisolone; Mibefradil; Reference Values	2000
Randomized comparison of T-type versus L-type calcium-channel blockade on exercise duration in stable angina: results of the Posicor Reduction of Ischemia During Exercise (PRIDE) trial. American heart journal, 2002, Volume: 144, Issue:1 Topics: Angina Pectoris; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Diltiazem; Double-Blind Method; Female; Humans; Male; Mibefradil; Middle Aged; Myocardial Ischemia	2002

Other Studies

43 other study(ies) available for diltiazem and mibefradil

Article	Year
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
Ro 40-5967, a novel calcium channel antagonist, protects against ventricular fibrillation. European journal of pharmacology, 1992, Dec-15, Volume: 229, Issue:2-3 Topics: Animals; Benzimidazoles; Binding Sites; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Disease Susceptibility; Dogs; Dose-Response Relationship, Drug; Heart Rate; Mibefradil; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Physical Exertion; Tetrahydronaphthalenes; Ventricular Fibrillation; Verapamil	1992
Ro 40-5967, in contrast to diltiazem, does not reduce left ventricular contractility in rats with chronic myocardial infarction. Journal of cardiovascular pharmacology, 1991, Volume: 17, Issue:2 Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Coronary Circulation; Depression, Chemical; Diltiazem; In Vitro Techniques; Male; Mibefradil; Myocardial Contraction; Myocardial Infarction; Perfusion; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes; Ventricular Function, Left	1991
Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlodipine. Journal of cardiovascular pharmacology, 1991, Volume: 18 Suppl 10 Topics: Amlodipine; Animals; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Hemodynamics; Male; Mibefradil; Nifedipine; Rats; Rats, Inbred Strains; Tetrahydronaphthalenes; Verapamil	1991
Modulation of adhesion molecule expression on endothelial cells by verapamil and other Ca++ channel blockers. Immunobiology, 1994, Volume: 191, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Benzimidazoles; Calcium Channel Blockers; Calmodulin; Cell Adhesion Molecules; Cells, Cultured; Diltiazem; E-Selectin; Endothelium, Vascular; Humans; Intercellular Adhesion Molecule-1; Isoquinolines; Mibefradil; Piperazines; Protein Kinase C; Sulfonamides; Tetrahydronaphthalenes; Umbilical Veins; Vascular Cell Adhesion Molecule-1; Verapamil	1994
Effects of the calcium channel blockers, diltiazem and Ro 40-5967, on systemic haemodynamics and plasma noradrenaline levels in conscious dogs with pacing-induced heart failure. British journal of pharmacology, 1994, Volume: 113, Issue:2 Topics: Animals; Benzimidazoles; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cardiac Output, Low; Cardiac Pacing, Artificial; Diltiazem; Dogs; Heart Rate; Hemodynamics; Mibefradil; Nitroprusside; Norepinephrine; Sympathetic Nervous System; Tetrahydronaphthalenes; Ventricular Dysfunction, Left	1994
Inhibition of signal Ca2+ in dog coronary arterial vascular muscle cells by Ro 40-5967. Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:1 Topics: Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Cells, Cultured; Coronary Vessels; Diltiazem; Dogs; Fluorometry; Mibefradil; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Norepinephrine; Potassium; Rats; Tetrahydronaphthalenes; Verapamil	1994
The effects of mibefradil, a novel calcium channel antagonist on ventricular arrhythmias induced by myocardial ischemia and programmed electrical stimulation. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Heart Ventricles; Mibefradil; Myocardial Ischemia; Tetrahydronaphthalenes; Verapamil	1996
[Introducing mibefradil--a new T-calcium channel blocker]. Der Internist, 1997, Volume: 38, Issue:12 Suppl M Topics: Antihypertensive Agents; Benzimidazoles; Calcium Channel Blockers; Diltiazem; Humans; Hypertension; Mibefradil; Nifedipine; Tetrahydronaphthalenes	1997
Short-term hemodynamic effects of mibefradil in dogs with chronic heart failure: comparison with diltiazem. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 285, Issue:2 Topics: Animals; Benzimidazoles; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dogs; Heart Failure; Hemodynamics; Mibefradil; Tetrahydronaphthalenes	1998
T- and L-type Ca2+-channel antagonists reduce contractility in guinea pig cardiac myocytes. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:2 Topics: Animals; Benzimidazoles; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Guinea Pigs; Male; Mibefradil; Myocardial Contraction; Myocardium; Tetrahydronaphthalenes	1998
Potent vasodilatory with minor cardiodepressant actions of mibefradil in human cardiac tissue. British journal of pharmacology, 1998, Volume: 125, Issue:1 Topics: Adult; Aged; Arteries; Benzimidazoles; Calcium; Calcium Channel Blockers; Diltiazem; Fluorescent Dyes; Fura-2; Heart; Humans; Mibefradil; Middle Aged; Myocardium; Nifedipine; Tetrahydronaphthalenes; Vasodilator Agents	1998
Immunomodulating effects of second-generation calcium channel blockers on experimental heart transplantation. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1999, Volume: 31, Issue:3 Topics: Adjuvants, Immunologic; Amlodipine; Animals; Benzimidazoles; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Therapy, Combination; Felodipine; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Mibefradil; Rats; Rats, Inbred Lew; Tetrahydronaphthalenes; Time Factors	1999
Effects of the T-type Ca(2+) channel blocker mibefradil on repolarization of guinea pig, rabbit, dog, monkey, and human cardiac tissue. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 292, Issue:2 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Female; Guinea Pigs; Heart; Heart Atria; Humans; In Vitro Techniques; Male; Mibefradil; Rabbits; Saimiri; Sotalol; Telemetry; Time Factors; Verapamil	2000
N-Type calcium channels control sympathetic neurotransmission in human heart atrium. Circulation, 2000, Feb-01, Volume: 101, Issue:4 Topics: Adult; Aged; Amlodipine; Calcium Channel Blockers; Calcium Channels, N-Type; Diltiazem; Electric Stimulation; Female; Heart; Heart Atria; Humans; Male; Mibefradil; Middle Aged; Norepinephrine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Sympathetic Nervous System; Synaptic Transmission; Verapamil	2000
Gonadotropin-releasing hormone-stimulated sperm binding to the human zona is mediated by a calcium influx. Biology of reproduction, 2000, Volume: 63, Issue:2 Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Egtazic Acid; Female; Gonadotropin-Releasing Hormone; Humans; Male; Mibefradil; Nifedipine; Pimozide; Sperm-Ovum Interactions; Spermatozoa; Verapamil; Zona Pellucida	2000
Ca2+-agonistic effect of a T-type Ca-channel blocker mibefradil (Ro 40-5967). Membrane & cell biology, 2000, Volume: 13, Issue:5 Topics: Amlodipine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cells, Cultured; Coronary Vessels; Diltiazem; Mibefradil; Muscle, Smooth, Vascular; Swine; Verapamil	2000
Distinct roles for L- and T-type Ca(2+) channels in regulation of atrial ANP release. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:6 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Atrial Natriuretic Factor; Bodily Secretions; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Diltiazem; Extracellular Space; Heart Atria; In Vitro Techniques; Mibefradil; Myocardial Contraction; Myocardium; Rabbits; Stroke Volume	2000
Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia-induced atrial remodeling in dogs. Cardiovascular research, 2001, Volume: 49, Issue:4 Topics: Analysis of Variance; Animals; Atrial Fibrillation; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Diltiazem; Dogs; Electric Countershock; Electrocardiography; Heart Atria; Mibefradil; Single-Blind Method; Statistics, Nonparametric; Tachycardia	2001
Effect of nitric oxide synthase inhibitor N(omega) nitro-L-arginine methyl ester on relaxant responses to calcium channel antagonists in isolated aortic rings from Dahl normotensive and hypertensive rats. Journal of cardiovascular pharmacology, 2002, Volume: 39, Issue:3 Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Enzyme Inhibitors; Female; Hypertension; Imidazoles; In Vitro Techniques; Mibefradil; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Potassium Chloride; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Vasoconstrictor Agents; Vasodilation	2002
Selective L-type, T-type, and nonspecific calcium-channel blockers for stable angina pectoris. American heart journal, 2002, Volume: 144, Issue:1 Topics: Angina Pectoris; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Diltiazem; Humans; Mibefradil; Myocardial Ischemia	2002
Evidence that action potential generation is not the exclusive determinant to trigger spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle. Acta physiologica Scandinavica, 2002, Volume: 176, Issue:1 Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; Male; Mibefradil; Muscle Contraction; Muscle, Smooth; Nisoldipine; Urinary Bladder	2002
T-type calcium channels in the regulation of afferent and efferent arterioles in rats. American journal of physiology. Renal physiology, 2004, Volume: 286, Issue:2 Topics: Animals; Arterioles; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Diltiazem; Dopamine Antagonists; Homeostasis; In Vitro Techniques; Male; Mibefradil; Pimozide; Potassium Chloride; Rats; Rats, Sprague-Dawley; Renal Circulation	2004
Differential calcium regulation by hydrogen peroxide and superoxide in vascular smooth muscle cells from spontaneously hypertensive rats. Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:2 Topics: Aminoquinolines; Animals; Calcium; Calcium Channels, L-Type; Calcium Channels, T-Type; Calcium Signaling; Diltiazem; Dose-Response Relationship, Drug; Hydrogen Peroxide; Male; Mesenteric Arteries; Mibefradil; Muscle Contraction; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxides; Verapamil	2004
Testosterone enhances calcium reabsorption by the kidney. Molecular and cellular endocrinology, 2004, Jul-30, Volume: 222, Issue:1-2 Topics: Absorption; Androgens; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, P-Type; Calcium Channels, T-Type; Diltiazem; Enzyme Inhibitors; Kidney; Kinetics; MAP Kinase Kinase Kinases; Mibefradil; omega-Conotoxins; Protein-Tyrosine Kinases; Rabbits; Signal Transduction; Testosterone	2004
Low-voltage-activated (T-type) calcium channels control proliferation of human pulmonary artery myocytes. Circulation research, 2005, Apr-29, Volume: 96, Issue:8 Topics: Calcium Channels, T-Type; Cell Proliferation; Cells, Cultured; Diltiazem; Humans; Lung; Mibefradil; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Artery; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering	2005
Inhibitory effects of L- and T-type calcium antagonists on contractions of human detrusor muscle. European journal of clinical pharmacology, 2006, Volume: 62, Issue:5 Topics: Adult; Aged; Analysis of Variance; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Carbachol; Diltiazem; Female; Humans; In Vitro Techniques; Male; Mibefradil; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Nimodipine; Potassium; Urinary Bladder; Verapamil	2006
Distinct roles of L- and T-type voltage-dependent Ca2+ channels in regulation of lymphatic vessel contractile activity. The Journal of physiology, 2014, Dec-15, Volume: 592, Issue:24 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Diltiazem; Lymphatic Vessels; Male; Membrane Potentials; Mibefradil; Muscle Contraction; Nickel; Nifedipine; Rats; Rats, Sprague-Dawley	2014