diltiazem has been researched along with lidocaine in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (19.35) | 18.7374 |
| 1990's | 21 (33.87) | 18.2507 |
| 2000's | 13 (20.97) | 29.6817 |
| 2010's | 15 (24.19) | 24.3611 |
| 2020's | 1 (1.61) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Dubinsky, B; Moore, JB; Press, JB; Sanfilippo, PJ; Urbanski, M | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Caron, G; Ermondi, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Narimatsu, A; Taira, N | 1 |
| Borowitz, JL; McLaughlin, JL | 1 |
| Hunt, CM; Stave, GM; Westerkam, WR | 1 |
| Nattel, S; Nayebpour, M | 1 |
| Imai, S; Ishibashi, T; Izumi, T; Matsubara, T; Nakazawa, M; Shibata, A; Yamazoe, M | 1 |
| Hunter, JB; Pegram, BL; Peters, T; Scheufler, E; Vogelgesang, R; Wermelskirchen, D; Wilffert, B | 1 |
| Peters, T; Scheufler, E | 1 |
| Amaha, K; Iwatsuki, N; Katoh, M; Ono, K | 1 |
| Cardinal, R; Carson, DL; Lambert, C; Nadeau, R; Parent, R; Shenasa, J; Vermeulen, M | 1 |
| Fournier, DJ; Grogan, DL; Kapur, PA | 1 |
| Schwartz, PJ; Vanoli, E | 1 |
| Campana, C; Chimienti, M; Falcone, C; Guasti, L; Klersy, C; Marangoni, E; Panciroli, C; Previtali, M; Regazzi Bonora, M; Salerno, JA | 1 |
| Hess, DS; Scheinman, MM | 1 |
| Bertrix, L; Bouzouita, K; Chah, QT; Faucon, G; Lang, J | 1 |
| Baim, DS; Brett, P; Bristow, MR; Clusin, WT; Harrison, DC; Jaillon, P; Schroeder, JS | 1 |
| Hattori, Y; Kanno, M; Nakaya, H | 1 |
| Goodenough, UW | 1 |
| Maekawa, N; Mikawa, K; Nishina, K; Obara, H | 1 |
| Berge, OG; Karlsson, U; Näsström, J | 1 |
| Honda, N; Miyagawa, A; Mizutani, A; Oyama, T; Taniguchi, K | 1 |
| Buxser, SE; Decker, DE; Horwitz, LD; Wallner, JS | 1 |
| Attolini, L; Bruguerolle, B; Gantenbein, M; Grignon, S; Jacob, D | 1 |
| Fraudeau, C; Luck, G; Mangani, F; Vérette, E | 1 |
| Kuraoka, F; Kuroiwa, A; Murasato, Y; Nagamoto, Y; Nakashima, Y; Urabe, T | 2 |
| Allessie, M; Anvari, A; Mast, F; Schmidinger, H; Schuster, E | 1 |
| Kusumoto, K; Notodihardjo, HW; Ogawa, Y | 1 |
| Fujii, Y; Saitoh, Y; Takahashi, S; Toyooka, H | 2 |
| Goto, T; Maeda, K; Ohara, F; Ohkubo, K; Ozaki, T; Seki, J; Sugimoto, T; Yamamoto, N | 1 |
| Chiba, S; Tsuboi, M | 1 |
| Akabas, MH; Bali, M; Jansen, M | 1 |
| Kaman, L; Medhi, B; Pandhi, P; Prakash, A; Prakash, O; Rao, RS | 1 |
| Cadet-Taïrou, A; Evrard, I; Legleye, S | 1 |
| Damaj, BB; Hu, L; Martin, R; Michniak-Kohn, BB; Silva, SM | 1 |
| Aydinoglu, A; Balcioglu, ME; Boleken, ME; Cevik, M; Karadag, CA; Koruk, I; Ocal, S | 1 |
| Biswas, G; Jindal, T; Karmakar, D; Mandal, SN | 1 |
| Daldrup, T; Hartung, B; Mahler, H; Pawlik, E; Plässer, G | 1 |
| Blinova, K; Chan, D; Crumb, WJ; Erato, C; Florian, J; Guo, P; Hong, M; Johannesen, L; Lin, J; Mason, JW; Mutlib, A; Sanabria, C; Stockbridge, N; Stohlman, J; Strauss, DG; Ugander, M; Vicente, J; Waite-Labott, K; Wang, J | 1 |
| Daldrup, T; Knuth, M; Pawlik, E; Temme, O | 1 |
| Andrews, LM; Koch, BCP; van der Nagel, BCH; van Domburg, B | 1 |
| Carroll, R; Draganic, B; Kwok, AMF; Leigh, L; Smith, SR; Zhao, J | 1 |
3 review(s) available for diltiazem and lidocaine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
New antiarrhythmic drugs.
Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil | 1983 |
Recent advances in the pharmacotherapy of chronic anal fissure: an update.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Anal Canal; Botulinum Toxins; Calcium Channel Blockers; Chronic Disease; Clinical Trials as Topic; Diltiazem; Fissure in Ano; Headache; Humans; Indoramin; Injections, Intralesional; Lidocaine; Nifedipine; Nitroglycerin; Ointments | 2008 |
7 trial(s) available for diltiazem and lidocaine
| Article | Year |
|---|---|
Attenuation of cardiovascular responses to tracheal extubation with diltiazem.
Topics: Adult; Anesthesia; Blood Pressure; Diltiazem; Double-Blind Method; Female; Heart Rate; Hemodynamics; Humans; Injections, Intravenous; Intubation, Intratracheal; Lidocaine | 1995 |
The effect of calcium channel antagonist administered by iontophoresis on the pain threshold.
Topics: Adult; Calcium Channel Blockers; Diltiazem; Drug Combinations; Female; Humans; Iontophoresis; Lidocaine; Male; Nicardipine; Pain; Sensory Thresholds; Time Factors; Verapamil | 1995 |
Diltiazem-lidocaine combination for the attenuation of cardiovascular responses to tracheal intubation in hypertensive patients.
Topics: Aged; Anesthetics, Intravenous; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Diltiazem; Double-Blind Method; Drug Combinations; Female; Heart Rate; Humans; Hypertension; Injections, Intravenous; Intubation, Intratracheal; Laryngoscopy; Lidocaine; Male; Middle Aged; Neuromuscular Depolarizing Agents; Neuromuscular Nondepolarizing Agents; Succinylcholine; Thiopental; Vecuronium Bromide | 1998 |
A prospective, randomized, double-blind study comparing the efficacy of diltiazem, glyceryl trinitrate, and lidocaine for the treatment of anal fissure in children.
Topics: Anesthetics, Local; Child; Child, Preschool; Diltiazem; Double-Blind Method; Female; Fissure in Ano; Humans; Infant; Lidocaine; Male; Nitroglycerin; Prospective Studies; Vasodilator Agents | 2012 |
Evaluation of the efficacy of a combination of diltiazem and periprostatic nerve block in pain control during transrectal ultrasonography-guided biopsy of the prostate.
Topics: Administration, Topical; Aged; Aged, 80 and over; Anesthetics, Local; Biopsy; Calcium Channel Blockers; Combined Modality Therapy; Diltiazem; Gels; Humans; Lidocaine; Male; Middle Aged; Nerve Block; Pain; Pain Management; Prostate; Prostatic Neoplasms; Ultrasonography, Interventional | 2013 |
Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trial.
Topics: Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Drug Therapy, Combination; Electrocardiography; Ether-A-Go-Go Potassium Channels; Female; Fluoroquinolones; Heart Rate; Humans; Lidocaine; Long QT Syndrome; Male; Mexiletine; Moxifloxacin; Phenethylamines; Prospective Studies; Sodium Channel Blockers; Sulfonamides; Young Adult | 2016 |
Topical Lidocaine or Lidocaine/Diltiazem Ointment Following Rubber Band Ligation of Hemorrhoids: A Prospective 3-Armed Randomized Controlled Trial.
Topics: Adolescent; Adult; Diltiazem; Hemorrhoids; Hospitals, University; Humans; Lidocaine; Ointments; Pain; Prospective Studies; Retrospective Studies | 2023 |
52 other study(ies) available for diltiazem and lidocaine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Synthesis of (aryloxy)alkylamines. 2. Novel imidazo-fused heterocycles with calcium channel blocking and local anesthetic activity.
Topics: Amines; Anesthetics, Local; Animals; Calcium Channel Blockers; Drug Evaluation, Preclinical; Heterocyclic Compounds; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Rabbits; Trachea | 1988 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.
Topics: Action Potentials; Anesthetics, Local; Animals; Atrioventricular Node; Benzazepines; Calcium; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Female; Heart Conduction System; In Vitro Techniques; Injections; Lidocaine; Male; Neural Conduction; Nifedipine; Procaine; Quinidine; Vasodilator Agents; Verapamil | 1976 |
Evidence for calcium channels in brine shrimp: diltiazem protects shrimp against cadmium.
Topics: Animals; Cadmium; Calcium Channels; Decapoda; Diltiazem; Lethal Dose 50; Lidocaine | 1992 |
Effect of age and gender on the activity of human hepatic CYP3A.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking | 1992 |
Pharmacologic response of cesium-induced ventricular tachyarrhythmias in anesthetized dogs.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Cesium; Chlorides; Chromatography, High Pressure Liquid; Diltiazem; Dogs; Electric Stimulation; Electrocardiography; Female; Heart Ventricles; Isoproterenol; Lidocaine; Magnesium Chloride; Male; Quinidine; Sodium Channels; Vagus Nerve | 1990 |
Effects of lidocaine on ischemic myocardial metabolism assessed by 31P-NMR in the isolated perfused rat heart.
Topics: Animals; Blood Pressure; Coronary Disease; Diltiazem; Energy Metabolism; Heart Rate; In Vitro Techniques; Lidocaine; Magnetic Resonance Spectroscopy; Male; Myocardium; Oxygen Consumption; Phosphorus; Rats; Rats, Inbred Strains | 1991 |
Uptake of catamphiphilic drugs into erythrocytes and muscular tissue correlates to membrane enrichment and to 45Ca displacement from phosphatidylserine monolayers.
Topics: Binding Sites; Calcium; Cell Membrane; Diltiazem; Erythrocytes; Flunarizine; Humans; In Vitro Techniques; Lidocaine; Muscles; Nitrendipine; Phosphatidylserines; Verapamil | 1990 |
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
Antiarrhythmic effect of diltiazem during halothane anesthesia in dogs and in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Benzazepines; Cardiac Complexes, Premature; Child; Child, Preschool; Diltiazem; Dogs; Epinephrine; Female; Halothane; Hemodynamics; Humans; Lidocaine; Middle Aged; Tachycardia | 1985 |
Opposite effects of lidocaine and diltiazem on electrophysiologic alterations in acutely ischemic porcine myocardium.
Topics: Animals; Coronary Disease; Diltiazem; Electrophysiology; Heart; Heart Rate; Lidocaine; Swine | 1989 |
Cardiovascular interactions of lidocaine with verapamil or diltiazem in the dog.
Topics: Animals; Diltiazem; Dogs; Drug Interactions; Female; Hemodynamics; Lidocaine; Male; Verapamil | 1988 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Ventricular arrhythmias during acute myocardial ischaemia in man. The role and significance of R-ST-T alternans and the prevention of ischaemic sudden death by medical treatment.
Topics: Angina Pectoris, Variant; Arrhythmias, Cardiac; Coronary Disease; Death, Sudden; Diltiazem; Electrocardiography; Ergonovine; Heart Conduction System; Humans; Lidocaine; Propranolol | 1986 |
Study of the ventricular antifibrillatory effects of calcium channel blocking agents in comparison with lidocaine on canine normal heart in situ.
Topics: Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Diltiazem; Dogs; Female; Heart; Heart Conduction System; Lidocaine; Male; Myocardial Contraction; Risk; Sinoatrial Node; Verapamil | 1983 |
The effects of diltiazem and reduced serum ionized calcium on ischemic ventricular fibrillation in the dog.
Topics: Animals; Benzazepines; Calcium; Citrates; Citric Acid; Coronary Circulation; Coronary Disease; Diltiazem; Dogs; Heart Rate; Heart Ventricles; Lidocaine; Ventricular Fibrillation | 1982 |
Effects of calcium antagonists and lidocaine on conduction delay induced by acute myocardial ischemia in dogs.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Coronary Disease; Diltiazem; Dogs; Heart Conduction System; Lidocaine; Time Factors; Verapamil | 1980 |
Tipping of flagellar agglutinins by gametes of Chlamydomonas reinhardtii.
Topics: 1-Methyl-3-isobutylxanthine; Agglutinins; Alkaloids; Animals; Bucladesine; Cadmium; Cell Adhesion; Cell Movement; Chlamydomonas reinhardtii; Colchicine; Diltiazem; Flagella; Germ Cells; Isoquinolines; Lanthanum; Lidocaine; Models, Biological; Plant Proteins; Protozoan Proteins; Reproduction; Staurosporine; Trifluoperazine | 1993 |
(+/-)-CP-96,345, an NK1 receptor antagonist, has local anaesthetic-like effects in a mammalian sciatic nerve preparation.
Topics: Action Potentials; Analysis of Variance; Animals; Biphenyl Compounds; Diltiazem; Dose-Response Relationship, Drug; Guinea Pigs; Hypnotics and Sedatives; In Vitro Techniques; Lidocaine; Male; Nerve Block; Neural Conduction; Neurokinin-1 Receptor Antagonists; Sciatic Nerve | 1994 |
Efficacy of lipid soluble, membrane-protective agents against hydrogen peroxide cytotoxicity in cardiac myocytes.
Topics: Animals; Antioxidants; Cell Death; Cell Membrane; Cells, Cultured; Chick Embryo; Chromans; Diltiazem; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydrogen Peroxide; Kinetics; L-Lactate Dehydrogenase; Lidocaine; Lipid Peroxidation; Lipids; Pregnatrienes; Probucol; Propranolol; Solubility | 1996 |
Effects of calcium antagonists on binding of local anesthetics to plasma proteins and erythrocytes in mice.
Topics: Anesthetics, Local; Animals; Blood Proteins; Bupivacaine; Calcium Channel Blockers; Diltiazem; Erythrocytes; In Vitro Techniques; Lidocaine; Male; Mice; Nicardipine; Protein Binding; Verapamil | 1996 |
On-line column-switching high-performance liquid chromatography analysis of cardiovascular drugs in serum with automated sample clean-up and zone-cutting technique to perform chiral separation.
Topics: Cardiovascular Agents; Chromatography, High Pressure Liquid; Diltiazem; Lidocaine; Linear Models; Metoprolol; Online Systems; Oxprenolol; Pindolol; Sensitivity and Specificity; Stereoisomerism; Verapamil | 1997 |
Effects of lidocaine and diltiazem on recovery of electrophysiologic activity during partial reperfusion following severe myocardial ischemia in canine hearts.
Topics: Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Coronary Vessels; Diltiazem; Disease Models, Animal; Dogs; Electrocardiography; Heart Conduction System; Infusions, Intravenous; Lidocaine; Myocardial Ischemia; Myocardial Reperfusion Injury; Random Allocation; Tachycardia, Ventricular; Treatment Outcome; Vasodilator Agents | 1997 |
Effects of lidocaine, ajmaline, and diltiazem on ventricular defibrillation energy requirements in isolated rabbit heart.
Topics: Ajmaline; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Cardiovascular Agents; Defibrillators, Implantable; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Countershock; Electrocardiography; Equipment Failure; Female; Heart; In Vitro Techniques; Lidocaine; Male; Rabbits; Ventricular Fibrillation | 1997 |
Effects of lidocaine and diltiazem on ventricular tachyarrhythmia and dispersion of conduction during severe myocardial ischemia in canine hearts.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dogs; Heart Conduction System; Lidocaine; Myocardial Ischemia; Sodium Channel Blockers; Tachycardia, Ventricular | 1997 |
The blood flow patterns of microsurgical procedures in rats with topical and systemic vasodilators.
Topics: Administration, Topical; Alprostadil; Analysis of Variance; Anastomosis, Surgical; Anesthetics, Local; Animals; Chlorpromazine; Diltiazem; Dopamine Antagonists; Femoral Artery; Laser-Doppler Flowmetry; Lidocaine; Male; Microsurgery; Rats; Rats, Wistar; Regional Blood Flow; Vasodilator Agents | 1998 |
Protective effect of FR168888, a new Na+/H+ exchange inhibitor, on ischemia and reperfusion-induced arrhythmia and myocardial infarction in rats: in comparison with other cardioprotective compounds.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Benzyl Alcohol; Benzyl Alcohols; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Guanidines; Hemodynamics; In Vitro Techniques; Ion Transport; Lidocaine; Lymphocytes; Male; Myocardial Infarction; Myocardial Ischemia; Propionates; Propranolol; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reperfusion Injury; Time Factors; Ventricular Fibrillation | 1999 |
Combined diltiazem and lidocaine reduces cardiovascular responses to tracheal extubation and anesthesia emergence in hypertensive patients.
Topics: Aged; Anesthesia Recovery Period; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Diltiazem; Drug Therapy, Combination; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Intubation, Intratracheal; Lidocaine; Male; Middle Aged; Orthopedic Procedures; Preanesthetic Medication | 1999 |
Effects of lidocaine on isolated, blood-perfused ventricular contractility in the dog.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Calcium; Calcium Channel Blockers; Calcium Chloride; Diltiazem; Dogs; Female; Heart Ventricles; In Vitro Techniques; Intracellular Fluid; Lidocaine; Male; Myocardial Contraction; Norepinephrine; Perfusion; Ventricular Function, Left | 1999 |
Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cyanobacteria; Diltiazem; Female; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Intracellular Signaling Peptides and Proteins; Lidocaine; Membrane Potentials; Mice; Molecular Sequence Data; Mutation; Ondansetron; Oocytes; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-B; Receptors, Serotonin, 5-HT3; Sequence Homology, Amino Acid; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Sodium Chloride; Xenopus laevis | 2008 |
Composition, purity and perceived quality of street cocaine in France.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Data Collection; Diltiazem; Drug Contamination; Drug Users; Female; France; Humans; Illicit Drugs; Lidocaine; Male; Middle Aged; Smoking; Young Adult | 2010 |
Transdermal and transbuccal drug delivery systems: enhancement using iontophoretic and chemical approaches.
Topics: Administration, Buccal; Administration, Cutaneous; Alanine; Animals; Azepines; Diltiazem; Drug Delivery Systems; In Vitro Techniques; Iontophoresis; Lidocaine; Mouth Mucosa; Nicotine; Skin; Skin Absorption; Sulfur Compounds; Swine | 2011 |
Drug-related death: adulterants from cocaine preparations in lung tissue and blood.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Diltiazem; Drug Contamination; Forensic Toxicology; Humans; Hydroxyzine; Illicit Drugs; Levamisole; Lidocaine; Liquid-Liquid Extraction; Lung; Mass Spectrometry; Narcotics; Phenacetin; Solid Phase Extraction | 2015 |
Analysis of cocaine adulterants in human brain in cases of drug-related death.
Topics: Brain Chemistry; Cetirizine; Cocaine; Cocaine-Related Disorders; Diltiazem; Drug Contamination; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyzine; Levamisole; Lidocaine; Narcotics; Phenacetin; Reproducibility of Results; Solid Phase Extraction | 2018 |
High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Topics: Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carvedilol; Chromatography, High Pressure Liquid; Diltiazem; Flecainide; High-Throughput Screening Assays; Humans; Lidocaine; Metoprolol; Propranolol; Reproducibility of Results; Sotalol; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Verapamil | 2019 |