diltiazem has been researched along with isradipine in 83 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 19 (22.89) | 18.7374 |
1990's | 50 (60.24) | 18.2507 |
2000's | 9 (10.84) | 29.6817 |
2010's | 5 (6.02) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Topliss, JG; Yoshida, F | 1 |
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Christen, MO; Feron, O; Godfraind, T; Wibo, M | 1 |
Araie, E; Miwa, K; Miyagi, Y; Sasayama, S | 1 |
Bick, IR; Felix, JP; Garcia, ML; Kaczorowski, GJ; King, VF; Shevell, JL; Slaughter, RS | 1 |
Ammon, HP; Roenfeldt, M; Safayhi, H | 1 |
Meluzín, J; Novák, M | 1 |
Mason, RP; Moisey, DM; Shajenko, L | 1 |
Abrams, AP; Black, HR; Hamilton, BP; Hamilton, JH; Isaacsohn, JL; Kochar, MS; Lewin, AJ; MacCarthy, EP; Madias, NE; Stein, GH | 1 |
Glossmann, H; Knaus, HG; Staudinger, R | 1 |
Keith, RA; Moore, WC; Patel, J; Salama, AI | 1 |
Ikeda, S; Nagao, T; Oka, J | 1 |
Böhm, M; Erdmann, E; Schwinger, RH | 3 |
Naitoh, T; Sugimoto, T; Toyo-Oka, T | 1 |
Dzúrik, R; Spustová, V | 1 |
Rampe, D; Triggle, DJ; Zheng, W | 1 |
Klockowski, PM; Lener, ME; Rocci, ML; Sirgo, MA | 1 |
Beaufort, P; Chatelain, P; Clinet, M; Laruel, R; Meysmans, L; Nokin, P | 1 |
Harada, Y; Kimura, R; Nakayama, K; Yamada, S | 1 |
Glossmann, H; Knaus, HG; Romanin, C; Scheffauer, F; Schindler, HG | 1 |
Birnbaumer, L; Brown, AM; Kim, HS; Lacerda, AE; Rampe, D | 1 |
Mironneau, C; Mironneau, J; Rakotoarisoa, L; Sayet, I | 1 |
Glossmann, H; Goll, A; Moosburger, K; Striessnig, J | 1 |
Hosey, MM; Maan, AC; Ptasienski, J | 1 |
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M; Renaud, JF; Romey, G; Schmid, A | 1 |
Highsmith, RF; Schwartz, A; Whitmer, KR; Williams-Lawson, JS | 1 |
Becker, C; Porzig, H | 1 |
Poder, T; Rampe, D; Schilling, WP; Zhao, ZY | 1 |
Fitscha, P; Gazsó, A; Gludovacz, D; Sinzinger, H; Weiss, K | 1 |
Lupínek, Z; Meluzín, J; Novák, M; Rotrekl, P | 1 |
Dillon, JS; Gu, XH; Liu, JJ; Nayler, WG | 1 |
Rutledge, A; Triggle, DJ; Wei, XY | 1 |
Ferry, DR; Glossmann, H; Goll, A; Linn, T | 1 |
Cook, NS; Hof, RP | 1 |
Bevan, JA; Hwa, JJ | 1 |
Hof, RP | 1 |
Golichowski, AM; Tzeng, DY | 1 |
Dacquet, C; Mironneau, C; Mironneau, J | 1 |
Ikema, S; Kato, T; Kinjo, N; Matsuzaki, T; Miyagi, H; Miyamoto, Y; Noguchi, K; Sakanashi, M | 1 |
Barhanin, J; Borsotto, M; Fosset, M; Galizzi, JP; Lazdunski, M | 1 |
Ferry, DR; Glossmann, H; Goll, A | 1 |
Fukuta, Y; Nakayama, K; Nozawa, Y | 1 |
Arneric, SP; Donnelly-Roberts, DL; Sullivan, JP | 1 |
Akimoto, T; Ichida, S; Kishino, H; Matsuda, N; Nakazaki, S; Wada, T | 1 |
Asico, LD; Eisner, GM; Felder, RA; Jose, PA; Yamaguchi, I | 1 |
Borelli, DA; Caristo, S; Costa, R; Maio, R; Mattioli, PL; Perticone, F; Pugliese, F; Torchia, L | 1 |
Carozzi, S; Fontana, I; Nasini, MG; Nocera, A; Pietrucci, A; Valente, U | 1 |
Locher, R; Lupo, E; Vetter, W; Weisser, B | 1 |
Fernandes, JB; Kornecki, E; Markell, MS; Naik, UP | 1 |
Prinz, H; Striessnig, J | 1 |
Frohlich, ED; Gossman, E; Oren, S | 1 |
Overstreet, DH; Pucilowski, O; Rezvani, AH | 1 |
Hagiwara, M; Nagao, T; Shimasue, K; Urushidani, T | 1 |
Schiffrin, EL; Touyz, RM | 1 |
Luus, HG; Müller, FO; Müller, FR; Schall, R | 1 |
Adachi-Akahane, S; Kanda, S; Kurokawa, J; Nagao, T | 1 |
Adachi-Akahane, S; Hagiwara, M; Nagao, T | 1 |
Brauns, T; Glossmann, H; Haugland, RP; Kimball, SD; Prinz, H; Striessnig, J | 1 |
Ngan, ET; Vincent, SR | 1 |
Attia, AS; Khayyal, MT; Saad, ES; Saad, SF | 1 |
Kobayashi, T; Mori, Y; Schwartz, A; Strobeck, M | 1 |
Bollo-Dragnic, S; Díaz-Araya, G; Letelier, ME; Marín-Catalán, R; Núñez-Vergara, LJ; Pino, L; Squella, JA | 1 |
Bailey, CP; Little, HJ; Molleman, A | 1 |
Mészáros, LG; Minarovic, I | 1 |
Schwartzkopff, B; Strauer, BE | 1 |
Conlin, PR; Hollenberg, NK; Seely, EW; Williams, GH | 1 |
Grabner, M; Hering, S; Kraus, RL; Ostler, D; Striessnig, J | 1 |
Seibold, JR; Sturgill, MG | 1 |
Chan, L; Jacob, LP; Malhotra, D; Shapiro, JI | 1 |
Murakami, Y; Okada, S; Wang, M; Yokotani, K | 1 |
Marche, P; Stepien, O | 1 |
Bidet, M; Martial, S; Martin, D; Melendez, E; Namorado, MD; Poujeol, C; Poujeol, P; Reyes, JL; Sanchez, E; Tauc, M; Valencia, L | 1 |
Fujino Oki, T; Kato, Y; Kurosawa, S; Nanri, M; Uchida, S; Yamada, S; Yoshida, K | 1 |
2 review(s) available for diltiazem and isradipine
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Bioequivalence of controlled-release calcium antagonists.
Topics: Calcium Channel Blockers; Clinical Trials as Topic; Delayed-Action Preparations; Diltiazem; Drugs, Generic; Humans; Isradipine; Therapeutic Equivalency; United States; United States Food and Drug Administration; Verapamil | 1997 |
9 trial(s) available for diltiazem and isradipine
Article | Year |
---|---|
[Comparison of the effects of diltiazem and isradipine in adrenergic beta receptor blockade in patients with stable angina pectoris].
Topics: Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Heart Rate; Humans; Isradipine; Male; Metipranolol; Middle Aged | 1992 |
A comparison of the safety of therapeutically equivalent doses of isradipine and diltiazem for treatment of essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Isradipine; Male; Middle Aged | 1992 |
Comparative evaluation of the effects of isradipine and diltiazem on antipyrine and indocyanine green clearances in elderly volunteers.
Topics: Aged; Aged, 80 and over; Antipyrine; Biomarkers; Calcium Channel Blockers; Diltiazem; Humans; Indocyanine Green; Isradipine; Liver; Liver Circulation; Oxidation-Reduction; Pyridines | 1990 |
[Comparison of the effects of diltiazem and isradipine in patients with chronic stable angina pectoris].
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Calcium Channel Blockers; Diltiazem; Exercise Test; Female; Heart Rate; Humans; Isradipine; Male; Middle Aged; Pyridines | 1989 |
[Isradipine versus diltiazem in the treatment of stable effort angina pectoris: ergometric evaluation in a crossover double-blind study].
Topics: Aged; Angina Pectoris; Cross-Over Studies; Diltiazem; Double-Blind Method; Electrocardiography; Exercise Test; Female; Humans; Isradipine; Male; Middle Aged | 1994 |
Immunosuppressive effects of different calcium channel blockers in human kidney allografts.
Topics: Calcium; Calcium Channel Blockers; Cyclosporine; Cytokines; Diltiazem; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isradipine; Kidney Transplantation; Lymphocytes; Prednisolone; Transplantation, Homologous; Verapamil | 1995 |
Effects of calcium entry blockers on distribution of blood volume.
Topics: Blood Volume; Calcium Channel Blockers; Diltiazem; Female; Head-Down Tilt; Hemodynamics; Humans; Isradipine; Male; Middle Aged; Posture; Vascular Capacitance; Vasoconstriction; Verapamil | 1996 |
Treatment of non-insulin-dependent diabetic hypertensive patients with Ca2+ channel blockers is associated with increased platelet sensitivity to insulin.
Topics: Angiotensin II; Antihypertensive Agents; Blood Platelets; Blood Pressure; Calcium; Calcium Channel Blockers; Diabetes Mellitus, Type 2; Diltiazem; Double-Blind Method; Female; Humans; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Isradipine; Male; Middle Aged; Vasoconstrictor Agents | 1995 |
Dissociation of vascular and adrenal responsiveness to angiotensin II following calcium channel blockade.
Topics: Adrenal Glands; Adult; Aldosterone; Angiotensin II; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Female; Humans; Hydrocortisone; Infusions, Intravenous; Isradipine; Male; Posture; Potassium; Water-Electrolyte Balance | 1998 |
72 other study(ies) available for diltiazem and isradipine
Article | Year |
---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Dihydropyridines; Diltiazem; Ileum; In Vitro Techniques; Isradipine; Kinetics; Morpholines; Muscle, Smooth; Parasympatholytics; Rats; Receptors, Nicotinic; Saponins | 1992 |
Effects of diltiazem and verapamil on (+)-PN 200-110 binding kinetics in dog cardiac membranes.
Topics: Allosteric Regulation; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dogs; Female; In Vitro Techniques; Isradipine; Kinetics; Male; Myocardium; Receptors, Nicotinic; Temperature; Verapamil | 1992 |
Bis(benzylisoquinoline) analogs of tetrandrine block L-type calcium channels: evidence for interaction at the diltiazem-binding site.
Topics: Alkaloids; Animals; Benzylisoquinolines; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluspirilene; Gallopamil; Isoquinolines; Isradipine; Kinetics; Molecular Conformation; Molecular Structure; Myocardium; Sarcolemma; Swine | 1992 |
KCl-induced insulin secretion from RINm5F cells is mediated through Ca2+ influx along L-type Ca2+ channels.
Topics: Animals; Calcium; Calcium Channels; Diltiazem; Insulin; Insulin Secretion; Insulinoma; Isradipine; Kinetics; omega-Conotoxins; Pancreatic Neoplasms; Peptides, Cyclic; Potassium Chloride; Radioimmunoassay; Rats; Stereoisomerism; Temperature; Tumor Cells, Cultured | 1992 |
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil | 1992 |
Positive heterotropic allosteric regulators of dihydropyridine binding increase the Ca2+ affinity of the L-type Ca2+ channel. Stereoselective reversal by the novel Ca2+ antagonist BM 20.1140.
Topics: Alkaloids; Allosteric Regulation; Animals; Benzothiazoles; Benzylisoquinolines; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cerebral Cortex; Diltiazem; Guinea Pigs; Isomerism; Isradipine; Kinetics; Macromolecular Substances; Models, Theoretical; Muscles; Oxadiazoles; Pyridines; Pyrrolidines; Rabbits; Thiazoles; Verapamil | 1991 |
Role of calcium in regulation of phosphoinositide signaling pathway.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Carbachol; Cations, Divalent; Cells, Cultured; Cerebral Cortex; Diltiazem; Egtazic Acid; Inositol; Inositol Phosphates; Isradipine; Kinetics; Models, Neurological; Neurons; Oxadiazoles; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Rats; Signal Transduction; Sulfonamides; Verapamil | 1991 |
Effects of four diltiazem stereoisomers on binding of d-cis-[3H]diltiazem and (+)-[3H]PN200-110 to rabbit T-tubule calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Isradipine; Kinetics; Muscles; Rabbits; Radioligand Assay; Receptors, Drug; Receptors, Nicotinic; Stereoisomerism; Tritium | 1991 |
Negative inotropic properties of isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardial tissue.
Topics: Adult; Aged; Calcium Channel Blockers; Calcium Chloride; Diltiazem; Electric Stimulation; Female; Heart; Heart Diseases; Humans; In Vitro Techniques; Isradipine; Male; Middle Aged; Myocardial Contraction; Nifedipine; Papillary Muscles; Pyridines; Verapamil | 1990 |
An endogenous Ca2+ channel agonist, endothelin-1, does not directly activate partially purified dihydropyridine-sensitive Ca2+ channel from cardiac muscle in a reconstituted system.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Endothelins; Heart; Isradipine; Kinetics; Liposomes; Microsomes; Oxadiazoles; Proteolipids; Sarcolemma; Swine; Verapamil | 1990 |
Effect of hippurate on glucose utilization in rat kidney cortex slices.
Topics: Animals; Benzoates; Benzoic Acid; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dose-Response Relationship, Drug; Gluconeogenesis; Glucose; Hippurates; In Vitro Techniques; Insulin; Isradipine; Kidney Cortex; Kinetics; Male; Pyridines; Rats; Rats, Inbred Strains | 1991 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
Negative inotropic activity of the calcium antagonists isradipine, nifedipine, diltiazem, and verapamil in diseased human myocardium.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Heart Diseases; Humans; Hypertension; Isradipine; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Pyridines; Vasodilation; Verapamil | 1991 |
Different negative inotropic activity of Ca2(+)-antagonists in human myocardial tissue.
Topics: Calcium Channel Blockers; Depression, Chemical; Diltiazem; Heart Atria; Heart Failure; Heart Transplantation; Humans; Isradipine; Myocardial Contraction; Nifedipine; Nitrendipine; Papillary Muscles; Pyridines; Verapamil | 1990 |
SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Indolizines; Isradipine; Male; Myocardium; Oxadiazoles; Phenethylamines; Radioligand Assay; Rats; Rats, Inbred Strains; Sarcolemma; Verapamil | 1990 |
Calcium channel receptor sites for (+)-[3H]PN 200-110 in coronary artery.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Cations, Divalent; Coronary Vessels; Diltiazem; Edetic Acid; Female; In Vitro Techniques; Isradipine; Kinetics; Male; Oxadiazoles; Receptors, Nicotinic; Swine; Verapamil | 1990 |
Heparin binds with high affinity to voltage-dependent L-type Ca2+ channels. Evidence for an agonistic action.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Carps; Cell Membrane; Cerebral Cortex; Dihydropyridines; Diltiazem; Electric Conductivity; Guinea Pigs; Heparin; Isradipine; Molecular Sequence Data; Muscles; Myocardium; Nicotinic Antagonists; Oxadiazoles; Polyelectrolytes; Polymers; Rabbits; Receptors, Nicotinic; Stereoisomerism; Verapamil | 1990 |
[3H]PN200-110 binding in a fibroblast cell line transformed with the alpha 1 subunit of the skeletal muscle L-type Ca2+ channel.
Topics: Animals; Brain; Calcium Channels; Cell Membrane; Cloning, Molecular; Diltiazem; Gallopamil; Imines; Isradipine; L Cells; Macromolecular Substances; Mice; Muscles; Myocardium; Oxadiazoles; Receptors, Nicotinic; Sarcolemma; Transfection | 1990 |
Selective modulation by membrane potential of desmethoxyverapamil binding to calcium channels in rat portal vein.
Topics: Animals; Barium; Binding Sites; Calcium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Isradipine; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Portal Vein; Pyridines; Rats; Strontium; Verapamil | 1990 |
Purified calcium channels have three allosterically coupled drug receptors.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allosteric Regulation; Amines; Animals; Calcium; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Guinea Pigs; Ion Channels; Isradipine; Muscles; Nifedipine; Oxadiazoles; Pyridines; Receptors, Drug; Verapamil | 1986 |
Influence of Mg++ on the effect of diltiazem to increase dihydropyridine binding to receptors on Ca++-channels in chick cardiac and skeletal muscle membranes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Chickens; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Isradipine; Magnesium; Membranes; Muscles; Myocardium; Nitrendipine; Oxadiazoles; Receptors, Nicotinic | 1986 |
Dihydropyridine-sensitive Ca2+ channels: molecular properties of interaction with Ca2+ channel blockers, purification, subunit structure, and differentiation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Affinity Labels; Animals; Bepridil; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cholic Acids; Diltiazem; Ion Channels; Isradipine; Kinetics; Macromolecular Substances; Molecular Weight; Muscles; Myocardial Contraction; Oxadiazoles; Pyridines; Pyrrolidines; Receptors, Nicotinic; Verapamil | 1986 |
Effect of calcium channel modulators on isolated endothelial cells.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Biological Products; Bradykinin; Calcium; Carbachol; Cattle; Diltiazem; Endothelium; Fura-2; Ion Channels; Isradipine; Nitric Oxide; Oxadiazoles; Thrombin; Verapamil | 1988 |
Potential-dependent allosteric modulation of 1,4-dihydropyridine binding by d-(cis)-diltiazem and (+/-)-verapamil in living cardiac cells.
Topics: Allosteric Regulation; Animals; Calcium; Diltiazem; Heart; In Vitro Techniques; Ion Channels; Isradipine; Membrane Potentials; Myocardium; Oxadiazoles; Rats; Sarcolemma; Verapamil | 1988 |
Calcium channel agonist and antagonist binding in a highly enriched sarcolemma preparation obtained from canine ventricle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dogs; Dose-Response Relationship, Drug; Heart Ventricles; Imines; In Vitro Techniques; Isradipine; Oxadiazoles; Sarcolemma | 1989 |
Calcium blockers: antiatherogenic action by influencing the prostaglandin-system.
Topics: Adult; Animals; Arteriosclerosis; Calcium Channel Blockers; Diltiazem; Epoprostenol; Female; Humans; In Vitro Techniques; Isradipine; Male; Malondialdehyde; Nifedipine; Platelet Aggregation; Prostaglandins; Pyridines; Rats; Rats, Inbred Strains; Verapamil | 1989 |
The failure of endothelin to displace bound, radioactively-labelled, calcium antagonists (PN 200/110, D888 and diltiazem).
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endothelins; Female; In Vitro Techniques; Isradipine; Oxadiazoles; Peptides; Rats; Rats, Inbred Strains; Receptors, Nicotinic; Verapamil | 1989 |
Voltage-dependent binding of 1,4-dihydropyridine Ca2+ channel antagonists and activators in cultured neonatal rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Diltiazem; Gallopamil; Heart Ventricles; In Vitro Techniques; Isradipine; Membrane Potentials; Oxadiazoles; Potassium; Rats | 1989 |
Molecular approach to the calcium channel.
Topics: Animals; Benzothiazoles; Binding Sites; Brain; Calcium; Cattle; Chemical Phenomena; Chemistry; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles; Thiazoles; Verapamil | 1985 |
Cardioprotection by the calcium antagonist PN 200-110 in the absence and presence of cardiodepression.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; In Vitro Techniques; Isradipine; Myocardial Contraction; Myocardium; Oxadiazoles; Rabbits; Time Factors; Verapamil | 1985 |
A nimodipine-resistant Ca2+ pathway is involved in myogenic tone in a resistance artery.
Topics: Analysis of Variance; Animals; Arteries; Calcium; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Isradipine; Male; Manganese; Muscle, Smooth, Vascular; Nicotinic Acids; Nimodipine; Oxadiazoles; Potassium; Rabbits; Vascular Resistance; Verapamil | 1986 |
Comparison of cardiodepressant and vasodilator effects of PN 200-110 (isradipine), nifedipine and diltiazem in anesthetized rabbits.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dose-Response Relationship, Drug; Heart; Isradipine; Myocardial Contraction; Nifedipine; Oxadiazoles; Rabbits; Vasodilation | 1987 |
Enhancement of binding of the dihydropyridine calcium antagonist PN200-110 to human myometrial sarcolemma by the heterologous calcium antagonist diltiazem.
Topics: Calcium Channel Blockers; Cell Fractionation; Diltiazem; Female; Humans; Isradipine; Kinetics; Myometrium; Oxadiazoles; Sarcolemma; Subcellular Fractions | 1987 |
Effects of calcium entry blockers on calcium-dependent contractions of rat portal vein.
Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Portal Vein; Potassium; Rats; Rats, Inbred Strains | 1987 |
Cardiovascular effects of the new calcium antagonist isradipine and of diltiazem in anesthetized open-chest dogs.
Topics: Anesthesia; Animals; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Female; Hemodynamics; Isradipine; Male; Pyridines; Regional Blood Flow; Time Factors; Vascular Resistance | 1988 |
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes.
Topics: Affinity Labels; Animals; Autoradiography; Benzazepines; Bepridil; Binding, Competitive; Calcium Channels; Diltiazem; Isradipine; Kinetics; Muscles; Oxadiazoles; Photochemistry; Pyrrolidines; Rabbits; Receptors, Nicotinic; Verapamil | 1986 |
Target size analysis of skeletal muscle Ca2+ channels. Positive allosteric heterotropic regulation by d-cis-diltiazem is associated with apparent channel oligomer dissociation.
Topics: Allosteric Regulation; Animals; Benzazepines; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Female; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Male; Muscles; Oxadiazoles; Stereoisomerism | 1983 |
Allosteric interaction of semotiadil fumarate, a novel benzothiazine, with 1,4-dihydropyridines, phenylalkylamines, and 1,5-benzothiazepines at the Ca(2+)-channel antagonist binding sites in canine skeletal muscle membranes.
Topics: Allosteric Regulation; Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Dogs; Female; Gallopamil; Isradipine; Kinetics; Male; Membranes; Muscles; Thiazoles | 1994 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cadmium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Isradipine; Neuroblastoma; Neurons; Nicotine; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Receptors, Nicotinic; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1995 |
Specific bindings of [3H](+)PN200-110 and [125I]omega-conotoxin to crude membranes from differentiated NG108-15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Bucladesine; Cell Differentiation; Cell Membrane; Diltiazem; Glioma; Hybrid Cells; Isradipine; Mollusk Venoms; Neuroblastoma; Nitrendipine; omega-Conotoxin GVIA; Potassium Chloride; Rats; Tumor Cells, Cultured; Verapamil | 1993 |
Role of renal dopamine D1 receptors in natriuresis induced by calcium channel blockers.
Topics: Animals; Benzazepines; Calcium Channel Blockers; Diltiazem; Diuresis; Dopamine; Drug Interactions; Infusions, Intra-Arterial; Isradipine; Kidney; Male; Natriuresis; Rats; Rats, Inbred WKY; Receptors, Dopamine D1; Renal Artery | 1994 |
In vitro antioxidant activity of calcium antagonists against LDL oxidation compared with alpha-tocopherol.
Topics: Adult; Amlodipine; Antioxidants; Calcium Channel Blockers; Copper; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Humans; Isradipine; Lipoproteins, LDL; Oxidation-Reduction; Reference Values; Thiobarbituric Acid Reactive Substances; Verapamil; Vitamin E | 1994 |
Lack of effect of isradipine on in vitro platelet activation.
Topics: Diltiazem; Humans; In Vitro Techniques; Isradipine; Platelet Activation; Platelet Aggregation; Solubility | 1993 |
Ligand-induced accelerated dissociation of (+)-cis-diltiazem from L-type Ca2+ channels is simply explained by competition for individual attachment points.
Topics: Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Calcium Channels; Computer Simulation; Diltiazem; Isradipine; Kinetics; Models, Biological; Protein Binding; Protein Conformation; Rabbits | 1993 |
Role of taste aversion in calcium channel inhibitor-induced suppression of saccharin and alcohol drinking in rats.
Topics: Alcohol Drinking; Animals; Avoidance Learning; Calcium Channel Blockers; Conditioning, Classical; Diltiazem; Dose-Response Relationship, Drug; Drinking; Isradipine; Male; Nicardipine; Rats; Rats, Sprague-Dawley; Saccharin; Taste | 1996 |
Effects of anandamide and arachidonic acid on specific binding of (+) -PN200-110, diltiazem and (-) -desmethoxyverapamil to L-type Ca2+ channel.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endocannabinoids; Isradipine; Male; Polyunsaturated Alkamides; Rabbits; Verapamil | 1996 |
Diltiazem derivatives modulate the dihydropyridine-binding to intact rat ventricular myocytes.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Isradipine; Male; Myocardium; Rats; Rats, Wistar | 1997 |
High-affinity binding of DTZ323, a novel derivative of diltiazem, to rabbit skeletal muscle L-type Ca++ channels.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Isradipine; Male; Muscle, Skeletal; Rabbits; Verapamil | 1997 |
L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Fluorescent Dyes; Isomerism; Isradipine; Kinetics; Nicotinic Acids; Nifedipine; Nitrendipine; Oxadiazoles; Rabbits | 1997 |
Carbamazepine and L-type calcium channel inhibitors: a binding assay study.
Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Calcium Channel Blockers; Carbamazepine; Diltiazem; In Vitro Techniques; Isradipine; Lithium; Male; Phenethylamines; Rats; Rats, Wistar; Verapamil | 1996 |
Influence of certain calcium-channel blockers on some aspects of lorazepam-dependence in mice.
Topics: Animals; Brain Chemistry; Calcium Channel Blockers; Diltiazem; Dopamine; Flunarizine; Isradipine; Lorazepam; Male; Mice; Norepinephrine; Serotonin; Substance Withdrawal Syndrome; Substance-Related Disorders | 1997 |
Inhibitory effects of a new neuroprotective diltiazem analogue, T-477, on cloned brain Ca2+ channels expressed in Xenopus oocytes.
Topics: Animals; Brain; Calcium Channel Blockers; Cloning, Molecular; Diltiazem; Female; In Vitro Techniques; Isradipine; Membrane Potentials; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Thiazines; Xenopus | 1997 |
Isradipine and lacidipine: effects in vivo and in vitro on Trypanosoma cruzi epimastigotes.
Topics: Animals; Calcium Channel Blockers; Cattle; Dihydropyridines; Diltiazem; Isradipine; Oxygen Consumption; Trypanocidal Agents; Trypanosoma cruzi; Verapamil | 1998 |
Comparison of the effects of drugs on hyperexcitability induced in hippocampal slices by withdrawal from chronic ethanol consumption.
Topics: Acetates; Alcoholism; Amines; Animals; Behavior, Animal; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Diltiazem; Ethanol; Felodipine; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Isradipine; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Substance Withdrawal Syndrome | 1998 |
Fluorescent probing with felodipine of the dihydropyridine receptor and its interaction with the ryanodine receptor calcium release channel.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Diltiazem; Dogs; Felodipine; Fluorescent Dyes; In Vitro Techniques; Isradipine; Kinetics; Muscle, Skeletal; Myocardium; Protein Conformation; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcolemma; Sarcoplasmic Reticulum; Spectrometry, Fluorescence | 1998 |
Objectives of high blood pressure treatment: left ventricular hypertrophy, diastolic function, and coronary reserve.
Topics: Antihypertensive Agents; Arterioles; Bisoprolol; Blood Pressure; Coronary Circulation; Diastole; Diltiazem; Disease Progression; Enalapril; Fibrosis; Heart Ventricles; Hemodynamics; Humans; Hypertension; Hypertrophy, Left Ventricular; Isradipine; Treatment Outcome; Ventricular Dysfunction, Left | 1998 |
Molecular mechanism of diltiazem interaction with L-type Ca2+ channels.
Topics: Alanine; Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Diltiazem; DNA Mutational Analysis; Electric Conductivity; Electrophysiology; Ion Channel Gating; Isradipine; Muscle, Skeletal; Mutagenesis | 1998 |
Rational use of calcium-channel antagonists in Raynaud's phenomenon.
Topics: Amlodipine; Calcium Channel Blockers; Diltiazem; Felodipine; Humans; Isradipine; Nicardipine; Nifedipine; Raynaud Disease | 1998 |
Absence of a dose-response of cyclosporine levels to clinically used doses of diltiazem and verapamil.
Topics: Administration, Oral; Calcium Channel Blockers; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Isradipine; Medical Records; Nifedipine; Radioimmunoassay; Retrospective Studies; Verapamil | 1999 |
Nicotine-induced noradrenaline release from the isolated rat stomach by activation of L- and N-type calcium channels.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Diltiazem; Gastric Mucosa; Hexamethonium; In Vitro Techniques; Isradipine; Male; Nicotine; Norepinephrine; omega-Conotoxin GVIA; Rats; Rats, Wistar; Stomach; Tetrodotoxin | 2000 |
Amlodipine inhibits thapsigargin-sensitive CA(2+) stores in thrombin-stimulated vascular smooth muscle cells.
Topics: Amlodipine; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Transporting ATPases; Cells, Cultured; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Intracellular Fluid; Isradipine; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Rats, Inbred WKY; Sarcoplasmic Reticulum; Signal Transduction; Thapsigargin; Thrombin; Verapamil | 2000 |
Nifedipine-activated Ca(2+) permeability in newborn rat cortical collecting duct cells in primary culture.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Biological Transport; Calcium; Calcium Channel Blockers; Cell Membrane Permeability; Cells, Cultured; Cytosol; Dihydropyridines; Diltiazem; Egtazic Acid; Gadolinium; Hydrogen Peroxide; Isradipine; Kidney Cortex; Kidney Tubules, Collecting; Kinetics; Lanthanum; Nifedipine; Protamines; Rats; Rats, Sprague-Dawley; Thapsigargin; Verapamil | 2001 |
Binding activities by propiverine and its N-oxide metabolites of L-type calcium channel antagonist receptors in the rat bladder and brain.
Topics: Analysis of Variance; Animals; Benzilates; Brain; Calcium Channels, L-Type; Diltiazem; Isradipine; Male; Mandelic Acids; N-Methylscopolamine; Protein Binding; Rats; Rats, Sprague-Dawley; Tritium; Urinary Bladder; Verapamil | 2007 |