diltiazem has been researched along with isomethyleugenol in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barlascini, N; Guzelian, PS; Hunt, CM; Saenger, P; Stave, GM; Watkins, PB; Watlington, CO; Wright, JT | 1 |
| Ascalone, V; Locatelli, M; Malavasi, B | 1 |
| Bouscarel, B; Ceryak, S; Fromm, H | 1 |
| Gorski, JC; Hall, SD; Hamman, MA; Jones, DR; Mayhew, BS; Rider, S | 1 |
| Asberg, A; Christensen, H; Molden, E | 1 |
| Dhalla, NS; Kawabata, K; Nijjar, MS; Okumura, K; Panagia, V; Shah, KR; Tappia, PS | 1 |
| Hori, S; Koishi, T; Kuroda, K; Kusuhara, M; Matsumoto, T; Nakagawa, M; Nishikawa, F; Ohnishi, N; Ohta, S; Soga, A; Takara, K; Yamashita, M; Yokoyama, T; Yoshioka, M | 1 |
| Kunze, KL; Lee, CA; Zhao, P | 1 |
8 other study(ies) available for diltiazem and isomethyleugenol
| Article | Year |
|---|---|
Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol.
Topics: Aged; Breath Tests; Carbon Radioisotopes; Cytochrome P-450 Enzyme System; Diltiazem; Erythromycin; Female; Humans; Hydrocortisone; Hydroxylation; Hypertension; Isoenzymes; Liver; Male; Methylation; Middle Aged; Sex Characteristics | 1992 |
Determination of diltiazem and its main metabolites in human plasma by automated solid-phase extraction and high-performance liquid chromatography: a new method overcoming instability of the compounds and interference problems.
Topics: Acetylation; Autoanalysis; Chromatography, High Pressure Liquid; Diltiazem; Drug Stability; Humans; Methylation; Molecular Structure; Quality Control; Sensitivity and Specificity | 1994 |
Comparative effect of ursodeoxycholic acid and calcium antagonists on the binding, uptake and degradation of LDL in isolated hamster hepatocytes.
Topics: Animals; Calcium Channel Blockers; Cricetinae; Diltiazem; Iodine Radioisotopes; Lipoproteins, LDL; Liver; Male; Mesocricetus; Methylation; Nifedipine; Ursodeoxycholic Acid; Verapamil | 1996 |
Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Catalysis; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Humans; Kinetics; Methylation; Microsomes, Liver; NADP; Oxidoreductases, N-Demethylating | 1999 |
CYP2D6 is involved in O-demethylation of diltiazem. An in vitro study with transfected human liver cells.
Topics: Acetylation; Calcium Channel Blockers; Cytochrome P-450 CYP2D6; Diltiazem; Epithelial Cells; Hepatocytes; Humans; Kinetics; Methylation; Transfection | 2000 |
Ca2+-antagonists inhibit the N-methyltransferase-dependent synthesis of phosphatidylcholine in the heart.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Dose-Response Relationship, Drug; Heart; Male; Methylation; Methyltransferases; Mitochondria, Heart; Myocardium; Organ Culture Techniques; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Sarcolemma; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Verapamil | 2001 |
Studies on interactions between functional foods or dietary supplements and medicines. I. Effects of Ginkgo biloba leaf extract on the pharmacokinetics of diltiazem in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochromes b5; Diltiazem; Drug Interactions; Enzyme Inhibitors; Ginkgo biloba; Half-Life; In Vitro Techniques; Injections, Intravenous; Intestine, Small; Male; Methylation; Microsomes; Microsomes, Liver; Oxidoreductases, N-Demethylating; Plant Extracts; Rats; Rats, Wistar | 2003 |
Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A.
Topics: Antifungal Agents; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hepatocytes; Humans; Ketoconazole; Kinetics; Methylation; Microsomes, Liver; Molecular Structure; Time Factors | 2007 |