diltiazem has been researched along with indomethacin in 63 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (19.05) | 18.7374 |
| 1990's | 19 (30.16) | 18.2507 |
| 2000's | 18 (28.57) | 29.6817 |
| 2010's | 13 (20.63) | 24.3611 |
| 2020's | 1 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Caron, G; Ermondi, G | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bajusz, D; Balogh, GT; Dargó, G; Müller, J; Simon, K | 1 |
| Inamasu, M; Morita, T; Sasaki, Y; Shinjo, A | 1 |
| Haught, WH; Lawson, DL; Mehta, JL; Yang, BC | 1 |
| Achmad, TH; Rao, GS | 1 |
| Fukuuchi, Y; Gotoh, F; Isozumi, K; Izumi, Y | 1 |
| Hassinen, IE; Ruskoaho, H; Uusimaa, PA; Vuolteenaho, O | 1 |
| Egashira, K; Hayashi, Y; Nakamura, M; Takeshita, A; Tomoike, H; Yamada, A | 1 |
| Gaginella, TS; Gullikson, GW; Moummi, C | 1 |
| Kaushal, RD; Sharif, MN; Wilson, TW | 1 |
| Chiba, S; Nakane, T | 1 |
| Abe, K; Nushiro, N; Omata, K; Sato, K; Seino, M; Tsunoda, K; Yoshinaga, K | 1 |
| Bertaccini, G; Coruzzi, G; Montanari, C; Poli, E | 1 |
| Bevan, JA; Tayo, FM | 1 |
| Katusic, ZS; Shepherd, JT; Vanhoutte, PM | 1 |
| Nakamura, Y; Sakai, K; Sugimoto, T; Yamazaki, T | 1 |
| Ivey, KJ; Razandi, M; Romano, M | 1 |
| Benveniste, J; Bourdillat, B; Brink, C; Haye-Legrand, I; Labat, C; Norel, X; Raffestin, B | 1 |
| Cooper, CL; Malik, KU; Shaffer, JE | 1 |
| Hardy, MA; Ware, HM | 1 |
| Shimazu, T; Usami, M | 1 |
| Ichihara, A; Saruta, T; Suzuki, H | 1 |
| Blaise, G; Dumont, L; Jasmin, G; Tanguay, M | 2 |
| Diwan, PV; Rao, PR | 2 |
| Gilani, AH; Rashid, F; Saeed, SA; Shah, BH | 1 |
| Belmonte, C; Chen, X; Gallar, J | 1 |
| Chiba, S; Matsumoto, T; Nakane, T | 1 |
| Attwood, D; Kawasaki, N; Miyazaki, S; Shirakawa, M; Suisha, F; Yamatoya, K | 1 |
| Cartier, R; Demers, P; Elkouri, S; Mathieu, P | 1 |
| Attwood, D; Kawasaki, N; Miyazaki, S; Ohkura, R; Sugimoto, S; Uno, Y | 1 |
| Chen, KM; Jia, YF; Morcos, SK; Wang, YX | 1 |
| Hanif, S; Khan, FL; Rahman, HB; Rahman, IH; Rasheed, H; Saeed, SA; Shah, BH; Shariff, AH | 1 |
| Hellige, G; Klockgether-Radke, AP; Neumann, P; Schulze, H | 1 |
| Angel, F; Aunis, D; Crenner, F; Ghia, JE; Metz-Boutigue, MH | 2 |
| Cao, LH; Choi, DH; Kang, DG; Kim, JS; Kim, SJ; Lee, H; Lee, HS; Lee, JK | 1 |
| McGinity, JW; Mehta, KA; Zhu, Y | 1 |
| Assreuy, AM; Criddle, DN; de Freitas Pires, A; Lima, RF; Soares, PM; Souza, EP | 1 |
| Ishii, K; Mori, A; Nakahara, T; Sakamoto, K; Tsuda, Y | 1 |
| Kulkarni, MG; Muthusamy, R | 1 |
| Lloyd, HS; Stewart, RAH; Tilyard, MW; Tomlin, AM; Woods, DJ | 1 |
2 review(s) available for diltiazem and indomethacin
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
61 other study(ies) available for diltiazem and indomethacin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design.
Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Humans; Hydrogen-Ion Concentration; Molecular Docking Simulation; Pharmaceutical Preparations; Protein Binding; Serum Albumin, Human; Spectrophotometry, Ultraviolet; Titrimetry | 2020 |
In vitro effect of the coronary vasodilator diltiazem on human and rabbit platelets.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Benzazepines; Blood Platelets; Calcium; Collagen; Diltiazem; Egtazic Acid; Humans; Indomethacin; Male; Platelet Aggregation; Rabbits; Vasodilator Agents | 1978 |
Slow channel calcium blockers attenuate reoxygenation-mediated vascular contraction, but augment anoxia-mediated vascular contraction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta; Diltiazem; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Oxyhemoglobins; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Thromboxane A2; Vasoconstriction; Verapamil | 1992 |
Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers.
Topics: Aspirin; Calcium Channel Blockers; Chemotaxis, Leukocyte; Diltiazem; Dose-Response Relationship, Drug; Endothelins; Humans; In Vitro Techniques; Indomethacin; Kinetics; Monocytes; Neomycin; Nifedipine; Probucol; Thioctic Acid; Verapamil | 1992 |
Role of cyclooxygenase system in cerebrovascular responsiveness: different effects of indomethacin on CO2 responsiveness and dilatation by Ca(2+)-channel blocker.
Topics: Animals; Brain; Carbon Dioxide; Cats; Cerebrovascular Circulation; Diltiazem; Hydrogen-Ion Concentration; Indomethacin; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Prostaglandins | 1992 |
Endothelin-induced atrial natriuretic peptide release from cultured neonatal cardiac myocytes: the role of extracellular calcium and protein kinase-C.
Topics: Alkaloids; Analysis of Variance; Animals; Animals, Newborn; Atrial Natriuretic Factor; Calcium; Cells, Cultured; Diltiazem; Endothelins; Heart; Indomethacin; Kinetics; L-Lactate Dehydrogenase; Myocardium; Perfusion; Protein Kinase C; Radioimmunoassay; Rats; Staurosporine | 1992 |
Mechanism of ergonovine-induced hyperconstriction of the large epicardial coronary artery in conscious dogs a month after arterial injury.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Diltiazem; Dogs; Electrophysiology; Endothelium, Vascular; Ergonovine; Heart Rate; Indomethacin; Ketanserin; Methysergide; Phenylephrine; Prazosin; Receptors, Serotonin | 1992 |
Effect of endothelin-1 on guinea pig gallbladder smooth muscle in vitro.
Topics: Animals; Arachidonic Acid; Atropine; Calcium; Cations, Divalent; Diltiazem; Endothelins; Gallbladder; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurotoxins; Nicardipine; Strontium | 1992 |
Diltiazem increases renal prostacyclin.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Animals; Blood Pressure; Diltiazem; Epoprostenol; Indomethacin; Kidney; Male; p-Aminohippuric Acid; Rats; Rats, Inbred Strains; Renal Circulation; Vasoconstriction | 1991 |
Adenosine constricts the isolated and perfused monkey coronary artery.
Topics: Adenosine; Adenosine Triphosphate; Animals; Coronary Vessels; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Indomethacin; Macaca; Male; Vasoconstriction; Vasodilation | 1990 |
Role of the renal kinin-prostaglandin system in diltiazem-induced natriuresis.
Topics: Animals; Aprotinin; Benzazepines; Diltiazem; Female; Hemodynamics; Indomethacin; Kallikreins; Kidney; Kinins; Natriuresis; Prostaglandins; Prostaglandins E; Rabbits; Regional Blood Flow; Vascular Resistance | 1986 |
Pharmacological characterization of mare uterus motility with special reference to calcium antagonists and beta-2-adrenergic stimulants.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Calcium Channel Blockers; Culture Media; Cyclic AMP; Diltiazem; Female; Hexoprenaline; Horses; In Vitro Techniques; Indomethacin; Myometrium; Nifedipine; Tetrodotoxin; Uterine Contraction; Verapamil | 1989 |
Extracellular calcium dependence of contraction and endothelium-dependent relaxation varies along the length of the aorta and its branches.
Topics: Acetylcholine; Animals; Aorta; Calcimycin; Calcium; Diltiazem; Endothelium; Extracellular Space; Gallopamil; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Quinacrine; Rabbits; Vasoconstriction | 1987 |
Endothelium-dependent contraction to stretch in canine basilar arteries.
Topics: Animals; Basilar Artery; Calcium; Cyclooxygenase Inhibitors; Diethylcarbamazine; Diltiazem; Dogs; Dose-Response Relationship, Drug; Endothelium; Homeostasis; Indomethacin; Papaverine; Potassium Chloride; Uridine Triphosphate; Vasoconstriction | 1987 |
Protective effects of the antianginal agent nicorandil on arachidonate-induced sudden death in rats: comparison with several antianginal agents and cyclooxygenase inhibitors.
Topics: Angina Pectoris; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Death, Sudden; Diltiazem; Indomethacin; Male; Mice; Niacinamide; Nicorandil; Nitroglycerin; Rats; Rats, Inbred Strains; Vasodilator Agents | 1985 |
Effect of calcium channel blocker diltiazem on cytoprotection and prostaglandin and sulfhydryl production by rat gastric epithelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cells, Cultured; Diltiazem; Dinoprostone; Epithelium; Ethanol; Gastric Mucosa; Indomethacin; Prostaglandins; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Taurocholic Acid; Verapamil | 1988 |
Effects of various pharmacological agents on isolated human bronchial and pulmonary arterial and venous muscle preparations contracted by leukotriene D4.
Topics: Arteries; Bronchi; Carbachol; Chromones; Cysteine; Diltiazem; Dose-Response Relationship, Drug; Female; Histamine; Humans; In Vitro Techniques; Indomethacin; Lung; Male; Muscle, Smooth, Vascular; SRS-A; Veins | 1987 |
Mechanism of action of angiotensin II and bradykinin on prostaglandin synthesis and vascular tone in the isolated rat kidney. Effect of Ca++ antagonists and calmodulin inhibitors.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin II; Animals; Bradykinin; Calcimycin; Calcium; Calcium Channel Blockers; Calmodulin; Dantrolene; Diltiazem; Dinoprostone; Gallic Acid; Imidazoles; Indomethacin; Kidney; Male; Nicotinic Acids; Nimodipine; Prostaglandins E; Quinacrine; Rats; Rats, Inbred Strains; Ryanodine; Stimulation, Chemical; Sulfonamides; Trifluoperazine; Vasoconstriction | 1985 |
Roles of Ca2+ and Na+ on the modulation of antidiuretic hormone action on urea permeability in toad urinary bladder.
Topics: Animals; Arginine Vasopressin; Bufo marinus; Calcimycin; Calcium; Carbachol; Cell Membrane Permeability; Diltiazem; Dinitrophenols; Female; Indomethacin; Iodoacetates; Iodoacetic Acid; Monensin; Quinidine; Sodium; Urea; Urinary Bladder | 1985 |
Further studies on the mechanism of phosphorylase activation in rabbit liver in response to splanchnic nerve stimulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Diltiazem; Electric Stimulation; Enzyme Activation; Indomethacin; Liver; Male; Norepinephrine; Phosphorylase a; Phosphorylases; Rabbits; Splanchnic Nerves; Verapamil | 1982 |
Effects of magnesium on the renin-angiotensin-aldosterone system in human subjects.
Topics: Adult; Aldosterone; Blood Pressure; Chlorides; Diltiazem; Diuresis; Electrolytes; Female; Humans; Indomethacin; Magnesium; Magnesium Sulfate; Male; Phosphates; Potassium; Random Allocation; Renin; Renin-Angiotensin System; Sodium | 1993 |
Impaired coronary sensitivity to diltiazem in experimental heart failure: involvement of the cyclooxygenase but not the nitric oxide-synthase pathway.
Topics: Animals; Coronary Vessels; Cricetinae; Cyclooxygenase Inhibitors; Diltiazem; Enzyme Inhibitors; Heart Failure; Heart Rate; Hemodynamics; In Vitro Techniques; Indomethacin; Mesocricetus; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Vasodilator Agents; Ventricular Function, Left | 1996 |
Permeability studies of cellulose acetate free films for transdermal use: influence of plasticizers.
Topics: Administration, Cutaneous; Cellulose; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diltiazem; Drug Delivery Systems; Indomethacin; Permeability; Plasticizers | 1997 |
Coronary and cardiac sensitivity to the vasoselective benzothiazepine-like calcium antagonist, clentiazem, in experimental heart failure.
Topics: Animals; Body Weight; Calcium Channel Blockers; Chronic Disease; Coronary Vessels; Cricetinae; Cyclooxygenase Inhibitors; Diltiazem; Enzyme Inhibitors; Heart; Heart Failure; In Vitro Techniques; Indomethacin; Mesocricetus; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase | 1997 |
Dopamine potentiation of calcium ionophore, A-23187-induced platelet aggregation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaloids; Androstadienes; Aspirin; Benzophenanthridines; Calcimycin; Calcium; Chlorpromazine; Diltiazem; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; GTP-Binding Proteins; Haloperidol; Homovanillic Acid; Humans; Indomethacin; Ion Transport; Ionophores; Phenanthridines; Phentolamine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Dopamine; Serotonin; Signal Transduction; Verapamil; Wortmannin | 1997 |
Reduction by antiinflammatory drugs of the response of corneal sensory nerve fibers to chemical irritation.
Topics: Acetic Acid; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Carbon Dioxide; Cats; Cornea; Cyclooxygenase Inhibitors; Diclofenac; Diltiazem; Electrophysiology; Female; Flurbiprofen; Indomethacin; Male; Nerve Fibers; Nociceptors; Pain; Trigeminal Nerve | 1997 |
UTP induces vascular responses in the isolated and perfused canine epicardial coronary artery via UTP-preferring P2Y receptors.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antinematodal Agents; Coronary Vessels; Diltiazem; Dogs; Female; Hexokinase; Indomethacin; Male; Protein Synthesis Inhibitors; Receptors, Purinergic P2; Saponins; Suramin; Triazines; Uridine Diphosphate; Uridine Triphosphate | 1997 |
Thermally reversible xyloglucan gels as vehicles for rectal drug delivery.
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbohydrate Sequence; Cardiovascular Agents; Chemistry, Pharmaceutical; Delayed-Action Preparations; Diltiazem; Drug Carriers; Gels; Glucans; Hot Temperature; Indomethacin; Male; Molecular Sequence Data; Polysaccharides; Rabbits; Suppositories; Xylans | 1998 |
[The vasoconstrictor effect of cyclosporine on the pulmonary vein is mediated by its vehicle: the cremophor].
Topics: Animals; Bicyclic Monoterpenes; Calcium Channel Blockers; Calcium Channels; Cyclooxygenase Inhibitors; Cyclosporine; Diltiazem; Dogs; Immunosuppressive Agents; Indomethacin; Isometric Contraction; Muscle, Smooth, Vascular; Pharmaceutical Vehicles; Polyethylene Glycols; Pulmonary Veins; Thromboxane A2; Vasoconstriction; Vasodilator Agents | 1998 |
Formulation and in vitro evaluation of polymeric films of diltiazem hydrochloride and indomethacin for transdermal administration.
Topics: Administration, Cutaneous; Animals; Cellulose; Delayed-Action Preparations; Diltiazem; Drug Delivery Systems; Evaluation Studies as Topic; Humans; In Vitro Techniques; Indomethacin; Male; Microscopy, Electron, Scanning; Permeability; Povidone; Rats; Rats, Wistar; Skin Absorption; X-Ray Diffraction | 1998 |
Thermally reversible xyloglucan gels as vehicles for oral drug delivery.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Carbohydrate Sequence; Delayed-Action Preparations; Diltiazem; Gels; Hot Temperature; Indomethacin; Male; Molecular Sequence Data; Pharmaceutical Vehicles; Polysaccharides; Rats; Rats, Wistar | 1999 |
Radiographic contrast media induced nephropathy: experimental observations and the protective effect of calcium channel blockers.
Topics: Animals; Calcium Channel Blockers; Chromium; Contrast Media; Diatrizoate; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epoprostenol; Indomethacin; Injections, Intraperitoneal; Iohexol; Kidney Diseases; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 2001 |
Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.
Topics: Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Estrenes; Flavonoids; Humans; In Vitro Techniques; Indomethacin; Kinetics; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Pyrrolidinones; Serotonin; Thromboxane A2; Verapamil | 2001 |
Activation of the K+ channel BK(Ca) is involved in the relaxing effect of propofol on coronary arteries.
Topics: Anesthetics, Intravenous; Animals; Calcium Channel Blockers; Coronary Vessels; Cyclooxygenase Inhibitors; Diltiazem; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Indomethacin; Muscle, Smooth, Vascular; Nitroarginine; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Propofol; Swine; Tetraethylammonium; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Effects of a chromogranin-derived peptide (CgA 47-66) in the writhing nociceptive response induced by acetic acid in rats.
Topics: Acetic Acid; Animals; Calcitonin Gene-Related Peptide; Cardiovascular Agents; Chromogranin A; Chromogranins; Corticotropin-Releasing Hormone; Diltiazem; Dose-Response Relationship, Drug; Indomethacin; Male; Pain; Pain Management; Peptide Fragments; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Substance P | 2004 |
The effect of a chromogranin A-derived peptide (CgA4-16) in the writhing nociceptive response induced by acetic acid in rats.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Calcium Channels, L-Type; Capsaicin; Chromogranin A; Chromogranins; Diltiazem; Dose-Response Relationship, Drug; Indomethacin; Injections, Intraperitoneal; Male; Pain Measurement; Peptide Fragments; Rats; Rats, Wistar; Substance P | 2004 |
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil | 2006 |
Influence of plasticizer level on the drug release from sustained release film coated and hot-melt extruded dosage forms.
Topics: Calorimetry, Differential Scanning; Chlorpheniramine; Chromatography, High Pressure Liquid; Citrates; Delayed-Action Preparations; Diltiazem; Drug Stability; Hot Temperature; Indomethacin; Microscopy, Electron, Scanning; Particle Size; Pharmaceutical Preparations; Plasticizers; Polymethacrylic Acids; Solubility; Spectrophotometry, Ultraviolet; Technology, Pharmaceutical; Thermogravimetry; Water; X-Ray Diffraction | 2006 |
Effects of anethole and structural analogues on the contractility of rat isolated aorta: Involvement of voltage-dependent Ca2+-channels.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Aorta; Calcium; Calcium Channels; Cardiovascular Agents; Diltiazem; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavoring Agents; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle Tonus; NG-Nitroarginine Methyl Ester; Nifedipine; Organ Culture Techniques; Oxidants; Phenylephrine; Rats; Rats, Wistar; Structure-Activity Relationship; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Resveratrol prevents bradykinin-induced contraction of rat urinary bladders by decreasing prostaglandin production and calcium influx.
Topics: Animals; Bradykinin; Calcium; Calcium Channel Agonists; Cyclooxygenase Inhibitors; Diltiazem; Dinoprostone; Dose-Response Relationship, Drug; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Potassium; Prostaglandins; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Urinary Bladder | 2011 |
pH Sensitive graft copolymers for zero order drug release: a mechanistic analysis.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Dicarboxylic Acids; Diffusion; Diltiazem; Dosage Forms; Epoxy Compounds; Hydrogen-Ion Concentration; Indomethacin; Methacrylates; Microspheres; Particle Size; Pharmacokinetics; Polyesters; Polymers; Solubility; Tablets; Verapamil | 2012 |
Understanding medicines with a propensity to increase the risk of heart failure: Combining existing knowledge with targeted population assessment.
Topics: Aged; Aged, 80 and over; Albuterol; Antifungal Agents; Case-Control Studies; Clozapine; Diltiazem; Drug Therapy, Combination; Female; Follow-Up Studies; Health Services Needs and Demand; Heart Failure; Hospitalization; Humans; Indomethacin; Male; Middle Aged; New Zealand; Pioglitazone; Primary Health Care; Propensity Score; Risk Factors | 2018 |