Page last updated: 2024-08-23

diltiazem and hydrochlorothiazide

diltiazem has been researched along with hydrochlorothiazide in 50 studies

Research

Studies (50)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (28.00)	18.7374
1990's	14 (28.00)	18.2507
2000's	10 (20.00)	29.6817
2010's	11 (22.00)	24.3611
2020's	1 (2.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Djian, J; Forette, B; Lekieffre, J; Luccioni, R; Roy, M	1
Boulet, AP; Chockalingam, A; Fodor, JG; Houde, M; Laplante, L; Lenis, J; Logan, AG; Robitaille, MN; Ryan, D; Spénard, J	1
Abraham, AS; Barchilon, E; Brooks, BA; Eylath, U; Grafstein, Y; Nubani, N; Shemesh, O	1
Chalmers, J; Taylor, S; Wing, L	1
Burris, JF; Cady, WJ; Oparil, S; Stewart, WH; Weber, M; Weir, MR	1
Swartz, SL	1
Gonzales, A; Kawanishi, DT; O'Rourke, RA; Rahimtoola, SH; Reid, CL	1
Hartman, E; Leehey, DJ	1
Fonteles, MC; Gadelha, MG; Menezes, AM; Rao, VS	1
Anderson, M; Bartels, D; Eidelson, BA; Labreche, DG; MacCarthy, EP; Massie, B; Ramanathan, KB; Tubau, JF; Ulep, D; Weiss, RJ	1
Horning, J; McClung, DE; McNulty, R; Simmons, J; TerWee, JA; Thomas, M; Williams, L; Zawada, ET	1
Leary, WP; van der Byl, K	1
Frishman, WH; Kirkendall, W; Lunn, J; McCarron, D; Moser, M; Schnaper, H; Smith, LK; Sowers, J; Swartz, SL; Zawada, ET	1
Klein, MD; Weiner, DA	1
Mohanty, PK; Sowers, JR; Thames, MD	1
Frishman, WH; Kirkendall, W; Lunn, J; McCarron, D; Moser, M; Schnaper, H; Smith, LK; Sowers, J; Swartz, S; Zawada, E	1
Lunn, J; Materson, BJ; Moser, M	1
Benowitz, N; Inouye, IK; Loge, D; Massie, BM; Simpson, P	1
Inouye, IK; Loge, D; Massie, BM; Simpson, P; Tubau, JF	1
Kokkinos, P; Narayan, P; Papademetriou, V	1
Anzalone, D; Chrysant, S; Fagan, T; Flamenbaum, W; Kaihlanen, PM; Lueg, M; Weir, MR	1
Cushman, WC; Freis, ED; Fye, C; Gottdiener, J; Hamburger, RJ; Kochar, MS; Lakshman, R; Massie, BM; Materson, BJ; Reda, DJ	1
Stewart, WH	1
Joy, A; Manning, G; Mathias, CJ; McDonald, CJ; Millar-Craig, MW	1
Anderson, RJ; Gottdiener, JS; Massie, BM; Materson, BJ; Reda, DJ; Williams, DW	1
Cappuccio, FP; MacGregor, GA	1
Dimmitt, DC; Geising, DH; Lanman, RC; Morrill, MB; Weir, SJ	1
Cushman, WC; Freis, ED; Lakshman, MR; Materson, BJ; Reda, DJ	1
Cushman, WC; Materson, BJ; Reda, DJ; Williams, DW	1
Leenen, FH; Ruzicka, M	1
Chen, CC; Dahly-Vernon, AJ; Dunn, KM; Ledbetter, SR; Murphy, SR; Roman, RJ; Williams, JM	1
Asare-Addo, K; Boateng, J; Conway, BR; Larhrib, H; Levina, M; Nokhodchi, A; Rajabi-Siahboomi, AR; Tetteh, J	1
Curtin, CR; Ford, L; Heald, D; Manitpisitkul, P; Shalayda, K; Wang, SS	1
Kelemen, A; Kónya, Z; Pintye-Hódi, K; Regdon, G; Sipos, B; Sovány, T	1
Aboul-Enein, HY; Ali, I; ALOthman, ZA; Alsheetan, KM	1

Reviews

3 review(s) available for diltiazem and hydrochlorothiazide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Treatment of angina pectoris and hypertension with sustained-release calcium channel-blocking drugs. Circulation, 1987, Volume: 75, Issue:6 Pt 2 Topics: Angina Pectoris; Biological Availability; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Drug Evaluation; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Verapamil	1987
Combination therapy as first-line treatment of arterial hypertension. The Canadian journal of cardiology, 2002, Volume: 18, Issue:12 Topics: Antihypertensive Agents; Atenolol; Captopril; Diltiazem; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Prazosin; Treatment Outcome	2002

Trials

23 trial(s) available for diltiazem and hydrochlorothiazide

Article	Year
Efficacy and tolerance of sustained-release diltiazem 300 mg and a diuretic in the elderly. Journal of cardiovascular pharmacology, 1990, Volume: 16 Suppl 1 Topics: Aged; Aging; Blood Pressure; Delayed-Action Preparations; Diltiazem; Drug Tolerance; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Triamterene	1990
Treatment of mild-to-moderate hypertension: comparison between a calcium-channel blocker and a potassium-sparing diuretic. Journal of cardiovascular pharmacology, 1991, Volume: 18 Suppl 9 Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Diltiazem; Diuretics; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Potassium; Single-Blind Method; Time Factors; Triamterene	1991
Effects of hydrochlorothiazide, diltiazem and enalapril on mononuclear cell sodium and magnesium levels in systemic hypertension. The American journal of cardiology, 1991, Nov-15, Volume: 68, Issue:13 Topics: Aged; Diltiazem; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Leukocytes, Mononuclear; Magnesium; Male; Sodium; Water-Electrolyte Balance	1991
Analysis of time trends, individual subject responses and background variation in crossover factorial studies with antihypertensive drugs. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1990, Volume: 8, Issue:4 Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Humans; Hydrochlorothiazide; Hypertension	1990
An assessment of diltiazem and hydrochlorothiazide in hypertension. Application of factorial trial design to a multicenter clinical trial of combination therapy. JAMA, 1990, Mar-16, Volume: 263, Issue:11 Topics: Adult; Analysis of Variance; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Logistic Models; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Research Design	1990
Endocrine and vascular responses in hypertensive patients to long-term treatment with diltiazem. Journal of cardiovascular pharmacology, 1987, Volume: 9, Issue:4 Topics: Adult; Aged; Angiotensin II; Blood Pressure; Body Weight; Diltiazem; Dinoprostone; Endocrine Glands; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prostaglandins E; Pulse; Renin	1987
Comparison of diltiazem and hydrochlorothiazide for treatment of patients 60 years of age or older with systemic hypertension. The American journal of cardiology, 1988, Dec-01, Volume: 62, Issue:17 Topics: Aged; Blood Pressure; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Placebos; Potassium; Random Allocation	1988
Diltiazem and propranolol in mild to moderate essential hypertension as monotherapy or with hydrochlorothiazide. Annals of internal medicine, 1987, Volume: 107, Issue:2 Topics: Adult; Age Factors; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propranolol; Random Allocation	1987
Renal-metabolic consequences of antihypertensive therapy with diltiazem versus hydrochlorothiazide. Mineral and electrolyte metabolism, 1987, Volume: 13, Issue:2 Topics: Antihypertensive Agents; Blood Pressure; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Electrolytes; Humans; Hydrochlorothiazide; Kidney; Middle Aged; Random Allocation; Renin	1987
Diltiazem compared with hydrochlorothiazide in the treatment of mild-to-moderate essential hypertension. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1988, Jul-02, Volume: 74, Issue:1 Topics: Adult; Aged; Blood Pressure; Diltiazem; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Pulse; Time Factors	1988
Comparison of hydrochlorothiazide and sustained-release diltiazem for mild-to-moderate systemic hypertension. The American journal of cardiology, 1987, Mar-01, Volume: 59, Issue:6 Topics: Adult; Age Factors; Clinical Trials as Topic; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Hypotension, Orthostatic; Male; Middle Aged; Potassium; Random Allocation	1987
Effects of hydrochlorothiazide and diltiazem on reflex vasoconstriction in hypertension. Hypertension (Dallas, Tex. : 1979), 1987, Volume: 10, Issue:1 Topics: Adult; Blood Pressure; Diltiazem; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Lower Body Negative Pressure; Male; Middle Aged; Random Allocation; Renin-Angiotensin System; Vascular Resistance; Vasoconstriction	1987
Diuretics versus calcium-channel blockers in systemic hypertension: a preliminary multicenter experience with hydrochlorothiazide and sustained-release diltiazem. The American journal of cardiology, 1985, Dec-06, Volume: 56, Issue:16 Topics: Aged; Benzazepines; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Diltiazem; Drug Therapy, Combination; Female; Heart Rate; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Random Allocation; Time Factors	1985
Comparative effects of diltiazem and hydrochlorothiazide in blacks with systemic hypertension. The American journal of cardiology, 1985, Dec-06, Volume: 56, Issue:16 Topics: Adult; Aged; Benzazepines; Black or African American; Blood Pressure; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Random Allocation; Time Factors	1985
Effects of diltiazem, metoprolol, enalapril and hydrochlorothiazide on frequency of ventricular premature complexes. The American journal of cardiology, 1994, Feb-01, Volume: 73, Issue:4 Topics: Analysis of Variance; Antihypertensive Agents; Cardiac Complexes, Premature; Diltiazem; Echocardiography; Electrocardiography, Ambulatory; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Metoprolol; Regression Analysis	1994
Comparison of the efficacy and tolerability of an angiotensin converting enzyme inhibitor (lisinopril) versus a calcium channel antagonist (diltiazem SR) in the treatment of moderate to severe hypertension. Journal of human hypertension, 1994, Volume: 8, Issue:7 Topics: Blood Pressure; Diltiazem; Double-Blind Method; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hypertension; Lisinopril; Male; Middle Aged	1994
Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. The New England journal of medicine, 1993, Apr-01, Volume: 328, Issue:13 Topics: Age Factors; Aged; Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Captopril; Clonidine; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin	1993
Double-blind, parallel, comparative multicentre study of a new combination of diltiazem and hydrochlorothiazide with individual components in patients with mild or moderate hypertension. Journal of human hypertension, 1996, Volume: 10, Issue:7 Topics: Adolescent; Adult; Aged; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Diastole; Diltiazem; Diuretics; Double-Blind Method; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Middle Aged; Sodium Chloride Symporter Inhibitors; Supine Position; Systole	1996
Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension: comparison of six antihypertensive agents. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Circulation, 1997, Apr-15, Volume: 95, Issue:8 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Captopril; Clonidine; Cohort Studies; Diltiazem; Diuretics; Double-Blind Method; Echocardiography; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardium; Organ Size; Prazosin; Prevalence; Risk Factors; Sodium Chloride Symporter Inhibitors; Treatment Outcome; United States; United States Department of Veterans Affairs	1997
Steady-state pharmacokinetics of diltiazem and hydrochlorothiazide administered alone and in combination. Biopharmaceutics & drug disposition, 1998, Volume: 19, Issue:6 Topics: Adult; Antihypertensive Agents; Area Under Curve; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Diuretics; Drug Combinations; Drug Interactions; Half-Life; Humans; Hydrochlorothiazide; Male; Sodium Chloride Symporter Inhibitors	1998
Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Archives of internal medicine, 1999, Mar-22, Volume: 159, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Captopril; Clonidine; Diltiazem; Diuretics; Double-Blind Method; Hospitals, Veterans; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins; Male; Middle Aged; Potassium; Prazosin; Time Factors; Treatment Outcome; United States	1999
Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial. Hypertension (Dallas, Tex. : 1979), 2001, Volume: 38, Issue:4 Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Clonidine; Diastole; Diltiazem; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin; Pressure; Pulse; Randomized Controlled Trials as Topic; Systole; Time Factors; Treatment Outcome	2001
Pharmacokinetic interactions between topiramate and diltiazem, hydrochlorothiazide, or propranolol. Clinical pharmacology in drug development, 2014, Volume: 3, Issue:5 Topics: Adolescent; Adult; Area Under Curve; Biotransformation; Diltiazem; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Female; Fructose; Half-Life; Healthy Volunteers; Humans; Hydrochlorothiazide; Male; Metabolic Clearance Rate; Middle Aged; Propranolol; Topiramate; United States; Young Adult	2014

Other Studies

24 other study(ies) available for diltiazem and hydrochlorothiazide

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Response of blood pressure, cardiac output, peripheral resistance, and exercise performance to substitution of calcium blocker for beta-blocker plus thiazide diuretic therapy in patients with both systemic hypertension and mild stable angina. Circulation, 1989, Volume: 80, Issue:6 Suppl Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Drug Therapy, Combination; Exercise Test; Female; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propranolol	1989
Effect of calcium-entry blockers on the diuretic response to hydrochlorothiazide in the rat. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1988, Volume: 21, Issue:5 Topics: Animals; Calcium Channel Blockers; Diltiazem; Diuresis; Female; Hydrochlorothiazide; Nifedipine; Potassium; Rats; Rats, Inbred Strains; Sodium; Verapamil	1988
Antihypertensive therapy with diltiazem and comparison with hydrochlorothiazide. The American journal of cardiology, 1984, Jun-01, Volume: 53, Issue:11 Topics: Aged; Benzazepines; Blood Pressure; Diltiazem; Epinephrine; Female; Heart Rate; Heart Ventricles; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Norepinephrine; Posture; Renin	1984
Failure of antihypertensive therapy with diuretic, beta-blocking and calcium channel-blocking drugs to consistently reverse left ventricular diastolic filling abnormalities. The American journal of cardiology, 1984, Jun-01, Volume: 53, Issue:11 Topics: Benzazepines; Blood Pressure; Cardiac Volume; Diltiazem; Female; Heart; Heart Rate; Heart Ventricles; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Propranolol; Radionuclide Imaging; Stroke Volume	1984
Application of response surface methodology and factorial designs to clinical trials for drug combination development. Journal of biopharmaceutical statistics, 1996, Volume: 6, Issue:3 Topics: Antihypertensive Agents; Clinical Trials as Topic; Data Interpretation, Statistical; Diltiazem; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Statistics as Topic	1996
Lack of effect of a diuretic added to diltiazem. Journal of human hypertension, 1997, Volume: 11, Issue:4 Topics: Antihypertensive Agents; Clinical Trials as Topic; Data Interpretation, Statistical; Diltiazem; Diuretics; Double-Blind Method; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Research Design; Sodium Chloride Symporter Inhibitors; Treatment Outcome	1997
Renoprotective effects of anti-TGF-β antibody and antihypertensive therapies in Dahl S rats. American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Jul-01, Volume: 303, Issue:1 Topics: Acute Kidney Injury; Animals; Antibodies, Anti-Idiotypic; Antihypertensive Agents; Blood Pressure; Captopril; Diltiazem; Disease Models, Animal; Female; Fibrosis; Hydrochlorothiazide; Hypertension; Male; Proteinuria; Rats; Rats, Inbred Dahl; Sex Characteristics; Sodium Chloride, Dietary; Transforming Growth Factor beta	2012
The effect of pH and ionic strength of dissolution media on in-vitro release of two model drugs of different solubilities from HPMC matrices. Colloids and surfaces. B, Biointerfaces, 2013, Nov-01, Volume: 111 Topics: Calorimetry, Differential Scanning; Delayed-Action Preparations; Diltiazem; Hydrochlorothiazide; Hydrogen-Ion Concentration; Hypromellose Derivatives; Osmolar Concentration; Solubility	2013
Physicochemical characterisation and investigation of the bonding mechanisms of API-titanate nanotube composites as new drug carrier systems. International journal of pharmaceutics, 2017, Feb-25, Volume: 518, Issue:1-2 Topics: Atenolol; Calorimetry, Differential Scanning; Diclofenac; Diltiazem; Drug Carriers; Drug Liberation; Hydrochlorothiazide; Microscopy, Electron, Scanning; Nanotubes; Solubility; Spectroscopy, Fourier Transform Infrared; Surface Properties; Thermogravimetry; Titanium	2017
Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2020, Jun-01, Volume: 1146 Topics: Adsorption; Antihypertensive Agents; Chromatography, High Pressure Liquid; Diltiazem; Furosemide; Humans; Hydrochlorothiazide; Irbesartan; Iron; Labetalol; Limit of Detection; Losartan; Metal Nanoparticles; Methyldopa; Nanocomposites; Polyvinyl Alcohol; Prazosin; Propranolol; Reproducibility of Results; Solid Phase Microextraction; Spironolactone; Valsartan	2020