diltiazem has been researched along with fluorouracil in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Enigbokan, MA; Hubbard, C; Preston, J; Thompson, JO | 1 |
| Delitheos, A; Giannakakou, P; Karavokyros, I; Tillgada, E | 1 |
| Fakih, MG; Raman, AK | 1 |
| Achilli, F; Farina, A; Malafronte, C; Valsecchi, MA | 1 |
| Atar, A; Korkmaz, ME; Ozin, B | 1 |
| Ambrosy, AP; Fisher, GA; Kunz, PL; Witteles, RM | 1 |
| Abu-Arafeh, A; Campbell, RT; Dalzell, JR | 1 |
| Bekaii-Saab, T; Blazer, M; Gulati, M; Reardon, J; Vargo, CA | 1 |
| Akindele, AJ; Amagon, KI; Oludadepo, GO; Osiagwu, DD; Singh, D | 1 |
| El-Husseiny, AA; El-Mahdy, HA; Gamal El-Din, AM; Kandil, YI | 1 |
| Boldig, K; Ganguly, A; Kadakia, M; Rohatgi, A | 1 |
1 review(s) available for diltiazem and fluorouracil
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
19 other study(ies) available for diltiazem and fluorouracil
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Characterization of and the influence of calcium channel blockers on the renal excretion of pyrimidine anticancer agents.
Topics: Absorption; Animals; Biological Transport; Blood Proteins; Calcium Channels; Carrier Proteins; Chromatography, High Pressure Liquid; Diltiazem; Floxuridine; Fluorouracil; Inulin; Kidney; Male; Membrane Proteins; Mice; Monosaccharide Transport Proteins; Nucleoside Transport Proteins; Verapamil | 1994 |
Effect of calcium channel blockers on the action of various antitumour agents in the yeast Saccharomyces cerevisiae.
Topics: Antineoplastic Agents; Calcium Channel Blockers; Cell Survival; Diltiazem; Doxorubicin; Fluorouracil; Saccharomyces cerevisiae; Verapamil | 1996 |
Capecitabine-induced headache responding to diltiazem.
Topics: Adult; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Diltiazem; Female; Fluorouracil; Headache; Humans; Rectal Neoplasms | 2007 |
Capecitabine-induced cardiotoxicity: when to suspect? How to manage? A case report.
Topics: Angina Pectoris; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvant; Colonic Neoplasms; Coronary Angiography; Coronary Vasospasm; Deoxycytidine; Diltiazem; Electrocardiography; Fluorouracil; Heart Rate; Humans; Male; Middle Aged; Tachycardia, Ventricular; Vasodilator Agents | 2009 |
Two cases of coronary vasospasm induced by 5-fluorouracil.
Topics: Adenocarcinoma; Administration, Oral; Adult; Antimetabolites, Antineoplastic; Cecal Neoplasms; Coronary Angiography; Coronary Disease; Coronary Vasospasm; Diltiazem; Duodenal Neoplasms; Echocardiography; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Nitrates; Vasodilator Agents | 2010 |
Capecitabine-induced chest pain relieved by diltiazem.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Anus Neoplasms; Calcium Channel Blockers; Capecitabine; Carcinoma, Squamous Cell; Chest Pain; Colorectal Neoplasms; Coronary Vasospasm; Deoxycytidine; Diltiazem; Electrocardiography; Female; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Prodrugs; Secondary Prevention; Treatment Outcome | 2012 |
Cardiotoxicity with 5-fluorouracil based agents: rechallenge cannot currently be safely advised.
Topics: Chest Pain; Colorectal Neoplasms; Deoxycytidine; Diltiazem; Female; Fluorouracil; Humans; Male | 2013 |
Successful Completion of Adjuvant Chemotherapy in a Patient With Colon Cancer Experiencing 5-Fluorouracil-Induced Cardiac Vasospasm.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cardiotoxicity; Chemotherapy, Adjuvant; Colonic Neoplasms; Coronary Vasospasm; Diltiazem; Female; Fluorouracil; Humans; Leucovorin; Middle Aged; Nifedipine; Organoplatinum Compounds; Vasodilator Agents | 2016 |
Protective effect of carvedilol alone and coadministered with diltiazem and prednisolone on doxorubicin and 5-fluorouracil-induced hepatotoxicity and nephrotoxicity in rats.
Topics: Acute Kidney Injury; Animals; Antibiotics, Antineoplastic; Carbazoles; Carvedilol; Chemical and Drug Induced Liver Injury; Diltiazem; Disease Models, Animal; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Kidney; Lipid Peroxidation; Liver; Oxidative Stress; Prednisolone; Propanolamines; Protective Agents; Random Allocation; Rats; Rats, Wistar; Treatment Outcome | 2018 |
Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Calcium Channel Blockers; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Deoxycytidine; Diltiazem; Drug Synergism; Fluorouracil; Gemcitabine; Humans; Pancreatic Neoplasms | 2020 |
Managing life-threatening 5-fluorouracil cardiotoxicity.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calcium Channel Blockers; Camptothecin; Cardiotoxicity; Cardiotoxins; Colorectal Neoplasms; Coronary Vasospasm; Diltiazem; Female; Fluorouracil; Humans; Irinotecan; Leucovorin; Nitrates | 2022 |