diltiazem has been researched along with enalapril in 48 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.33) | 18.7374 |
| 1990's | 27 (56.25) | 18.2507 |
| 2000's | 9 (18.75) | 29.6817 |
| 2010's | 8 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Graack, GK; Ko, Y; Sachinidis, A; Vetter, H; Wieczorek, AJ | 1 |
| Djian, J; Fermé, I; Tcherdakoff, P | 1 |
| Applegate, WB; Koch, GG; Luhr, JC; Park, GD; Phillips, HL; Schnaper, H; Schocken, D; Shepherd, AM | 1 |
| Abraham, AS; Barchilon, E; Brooks, BA; Eylath, U; Grafstein, Y; Nubani, N; Shemesh, O | 1 |
| Bakris, GL | 1 |
| Chalmers, J; Taylor, S; Wing, L | 1 |
| Bianco, G; Cellamare, G; Poppa, E; Sgobba, G | 1 |
| Bidiville, J; Brunner, HR; Nussberger, J; Porchet, M; Waeber, B; Waeber, G | 2 |
| Lowenthal, DT | 1 |
| Dabsys, SM; Delorenzi, A; Finkielman, S; Garcia, SI; Martinez, VN; Nahmod, VE; Pirola, CJ; Santajuliana, D | 1 |
| Kokkinos, P; Narayan, P; Papademetriou, V | 1 |
| Hagihara, T; Kishi, Y; Matsumoto, G; Matsuo, H; Naka, K; Nanjo, K; Ohoshi, T; Sanke, T; Sasaki, H; Sowa, R | 1 |
| Buja, LM; Casscells, SW; Goff, DC; Gould, KL | 1 |
| Collins, TJ; Mehra, MR; Ramee, SR; Smart, FW; Stapleton, DD; Ventura, HO | 1 |
| Cervenka, L; Heller, J | 1 |
| Adamczyk, M; Auch-Schwelk, W; Bossaller, C; Brodde, OE; Busch, F; Duske, E; Fleck, E; Götze, S | 1 |
| Bernard-Fernier, MF; de La Garoullaye, A; Gosse, P; Zannad, F | 1 |
| Cervenka, L; Heller, J; Hellerová, S | 1 |
| Applegate, WB | 1 |
| Bujor, MA; Davis, BB; Myles, PS; Olenikov, I | 1 |
| Applegate, WB; Cohen, JD; Davis, A; Green, S; Wolfson, P | 1 |
| Afonso, LC; Bedford-Rice, K; Raman, BB; Sowers, JR; Standley, PR | 1 |
| Bagdon, WJ; Herold, EG; Los, LE; Welsh, DA; Zacchei, AG | 1 |
| Adrogue, HJ; Goldstein, R; Hricik, DE; Levine, BS; Weinberg, MS | 1 |
| Pojoga, L; Raicu, M; Simionescu, M; Simionescu, N | 1 |
| Cohen, JD; Cushman, WC; Jones, RP; Marbury, TC; Rhoades, RB; Smith, LK | 1 |
| Chrysant, SG; Conradi, E; Gavras, H; Goldstein, R; Marbury, TC; Niederman, AL | 1 |
| Chrysant, SG; Gavras, H; Goldstein, R; Marbury, TC; Niederman, AL | 1 |
| Schwartzkopff, B; Strauer, BE | 1 |
| Barta, J; Kovács, T; Nagy, J; Szelestei, T | 1 |
| Chicherina, EN; Malykh, SV | 1 |
| Brown, CA; Brown, SA; Cartier, LM; Dietrich, UM; Mathur, S; Munday, JS; Newell, MA; Sheldon, SE | 1 |
| Antosová, M; Franová, S; Nosál', S; Nosál'ová, G | 1 |
| Inamdar, MN; Kumar, NP; Venkataraman, BV | 1 |
| Linnet, K; Rasmussen, HB; Thomsen, R | 1 |
| Fredholm, DV; Hall, NH; Heard, DJ; Jones, AE; Russell, K | 1 |
| Beanlands, RS; Burns, KD; Croteau, E; DaSilva, JN; deKemp, RA; Hadizad, T; Ismail, B | 1 |
2 review(s) available for diltiazem and enalapril
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Managing the older patient with hypertension.
Topics: Aged; Aged, 80 and over; Aging; Antihypertensive Agents; Atenolol; Delayed-Action Preparations; Diltiazem; Enalapril; Forecasting; Humans; Hypertension; Randomized Controlled Trials as Topic; Systole | 1993 |
15 trial(s) available for diltiazem and enalapril
| Article | Year |
|---|---|
Comparative study on monotherapy with sustained-release diltiazem 300 mg and enalapril 20 mg in mild to moderate arterial hypertension.
Topics: Blood Pressure; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Tolerance; Electrocardiography; Enalapril; Humans; Hypertension; Middle Aged | 1990 |
A randomized controlled trial of the effects of three antihypertensive agents on blood pressure control and quality of life in older women.
Topics: Aged; Atenolol; Blood Pressure; Diltiazem; Double-Blind Method; Enalapril; Female; Humans; Hypertension; Quality of Life | 1991 |
Effects of hydrochlorothiazide, diltiazem and enalapril on mononuclear cell sodium and magnesium levels in systemic hypertension.
Topics: Aged; Diltiazem; Enalapril; Female; Humans; Hydrochlorothiazide; Hypertension; Leukocytes, Mononuclear; Magnesium; Male; Sodium; Water-Electrolyte Balance | 1991 |
Effects of diltiazem or lisinopril on massive proteinuria associated with diabetes mellitus.
Topics: Angiotensin-Converting Enzyme Inhibitors; Clinical Trials as Topic; Diabetes Complications; Diltiazem; Enalapril; Female; Humans; Lisinopril; Male; Middle Aged; Prospective Studies; Proteinuria | 1990 |
Analysis of time trends, individual subject responses and background variation in crossover factorial studies with antihypertensive drugs.
Topics: Antihypertensive Agents; Atenolol; Blood Pressure; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Humans; Hydrochlorothiazide; Hypertension | 1990 |
Angiotensin-converting enzyme inhibitor versus calcium antagonist in the treatment of hypertension.
Topics: Adult; Blood Pressure; Diltiazem; Enalapril; Female; Humans; Hypertension; Male; Middle Aged | 1987 |
Individual responses to converting enzyme inhibitors and calcium antagonists.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Calcium Channel Blockers; Clinical Trials as Topic; Diltiazem; Enalapril; Enalaprilat; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Random Allocation; Time Factors | 1988 |
Effects of diltiazem, metoprolol, enalapril and hydrochlorothiazide on frequency of ventricular premature complexes.
Topics: Analysis of Variance; Antihypertensive Agents; Cardiac Complexes, Premature; Diltiazem; Echocardiography; Electrocardiography, Ambulatory; Enalapril; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Metoprolol; Regression Analysis | 1994 |
[Antihypertensive efficacy and tolerability of diltiazem and enalapril, alone or in combination. DESG. Diltiazem Enalapril Study Group].
Topics: Adult; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Time Factors | 1994 |
Evaluation of blood pressure response to the combination of enalapril (single dose) and diltiazem ER (four different doses) in systemic hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Enalapril; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged | 1996 |
Evaluation of enalapril/diltiazem ER in hypertensive patients with coexisting renal dysfunction. Enalapril/Diltiazem ER in Hypertensive Renal Disease Group.
Topics: Adult; Aged; Blood Pressure; Creatinine; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Proteinuria | 1996 |
Comparison of the fixed combination of enalapril/diltiazem ER and their monotherapies in stage 1 to 3 essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Diltiazem; Double-Blind Method; Drug Combinations; Enalapril; Female; Humans; Hypertension; Male; Middle Aged; Outcome Assessment, Health Care | 1998 |
Evaluation of enalapril combined with diltiazem ER in patients with stage 3-4 essential hypertension.
Topics: Adult; Antihypertensive Agents; Diltiazem; Disease Progression; Drug Therapy, Combination; Enalapril; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged | 1998 |
Clinical utility of long-term enalapril/diltiazem ER in stage 3-4 essential hypertension. Long-term Use of Enalapril/Diltiazem ER in Stage 3-4 Hypertension Group.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Enalapril; Female; Humans; Hypertension; Male; Middle Aged | 1997 |
[Drug correction of myocardial ischemia in patients with chronic obstructive bronchitis].
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Bronchitis, Chronic; Calcium Channel Blockers; Cardiovascular Agents; Diltiazem; Echocardiography; Electrocardiography; Electrocardiography, Ambulatory; Enalapril; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Time Factors; Treatment Outcome | 2003 |
31 other study(ies) available for diltiazem and enalapril
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Action of metoprolol, enalapril, diltiazem, verapamil, and nifedipine on cell growth of vascular smooth muscle cells.
Topics: Animals; Cell Division; Diltiazem; Enalapril; Metoprolol; Muscle, Smooth, Vascular; Nifedipine; Rats; Rats, Inbred WKY; Thymidine | 1992 |
[Calcium antagonists vs ACE inhibitors in the treatment of essential arterial hypertension in the aged].
Topics: Age Factors; Aged; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Diltiazem; Drug Evaluation; Enalapril; Female; Humans; Hypertension; Male; Nifedipine; Verapamil | 1989 |
New drugs for hypertension.
Topics: Antihypertensive Agents; Bumetanide; Diltiazem; Dipeptides; Enalapril; Guanabenz; Guanidines; Humans; Indapamide; Labetalol; Nifedipine; Pindolol; Verapamil | 1984 |
Thyrotropin-releasing hormone hyperactivity in the preoptic area of spontaneously hypertensive rats.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Northern; Calcium Channel Blockers; Diltiazem; Enalapril; Hypertension; Male; Preoptic Area; Radioimmunoassay; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Thyrotropin-Releasing Hormone; RNA, Messenger; Thyrotropin-Releasing Hormone; Time Factors; Up-Regulation | 1995 |
Nicardipine may impair glucose metabolism in hypertensive diabetic patients.
Topics: Adult; Aged; Atenolol; Carteolol; Diabetes Mellitus, Type 2; Diltiazem; Enalapril; Female; Glucose; Glycated Hemoglobin; Humans; Hypertension; Male; Metoprolol; Middle Aged; Nicardipine; Propanolamines | 1994 |
Non-invasive management of coronary artery disease. Report of a meeting at the University of Texas Medical School at Houston.
Topics: Aged; Anticholesteremic Agents; Aspirin; beta Carotene; Carotenoids; Cholesterol, Dietary; Coronary Disease; Diet, Fat-Restricted; Diltiazem; Drug Therapy, Combination; Enalapril; Humans; Lovastatin; Male; Simvastatin; Tomography, Emission-Computed; Vitamins | 1995 |
An intravascular ultrasound study of the influence of angiotensin-converting enzyme inhibitors and calcium entry blockers on the development of cardiac allograft vasculopathy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Captopril; Coronary Disease; Diltiazem; Enalapril; Female; Heart Transplantation; Humans; Hyperplasia; Lisinopril; Male; Middle Aged; Nifedipine; Transplantation, Homologous; Tunica Intima; Ultrasonography, Interventional; Verapamil | 1995 |
A comparison of the effect of feeding a low-protein diet and of pharmacological intervention on the course of ablation nephropathy in the rat.
Topics: Analysis of Variance; Animals; Body Weight; Diet, Protein-Restricted; Diltiazem; Disease Models, Animal; Drug Evaluation, Preclinical; Enalapril; Kidney Diseases; Male; Nephrectomy; Rats; Rats, Wistar; Time Factors | 1995 |
Selective downregulation of rat cardiac beta 1-adrenoceptors by cyclosporine A: prevention by diltiazem or angiotensin-converting enzyme inhibitors.
Topics: Animals; Cyclosporine; Diltiazem; Down-Regulation; Enalapril; Heart; Male; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1 | 1995 |
[The effect of a low-protein diet and certain pharmaceutical agents on the course of ablation nephropathy in rats].
Topics: Animals; Dietary Proteins; Diltiazem; Enalapril; Kidney Failure, Chronic; Male; Nephrectomy; Rats; Rats, Wistar | 1994 |
ACE-inhibitors, calcium antagonists and low systemic vascular resistance following cardiopulmonary bypass. A case-control study.
Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Captopril; Cardiopulmonary Bypass; Case-Control Studies; Coronary Artery Bypass; Critical Care; Diltiazem; Dopamine; Enalapril; Female; Heart Valves; Humans; Length of Stay; Male; Middle Aged; Nifedipine; Norepinephrine; Retrospective Studies; Single-Blind Method; Syndrome; Vascular Resistance; Verapamil | 1993 |
Effects of antihypertensive therapy on platelet cytosolic calcium responses to low density lipoprotein cholesterol.
Topics: Aged; Aged, 80 and over; Blood Platelets; Calcium; Cholesterol, LDL; Cytosol; Diltiazem; Drug Therapy, Combination; Enalapril; Felodipine; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Prospective Studies | 1996 |
Gender differences in toxicokinetics, liver metabolism, and plasma esterase activity: observations from a chronic (27-week) toxicity study of enalapril/diltiazem combinations in rats.
Topics: Animals; Antihypertensive Agents; Diltiazem; Enalapril; Esterases; Female; Liver; Male; Rats; Rats, Sprague-Dawley; Sex Factors | 1996 |
The effect of ACE inhibitors on atheroma formation is potentiated by association with a calcium channel blocker. A biochemical and ultrastructural study.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Valve; Arteriosclerosis; Calcium Channel Blockers; Captopril; Cholesterol; Coronary Vessels; Cricetinae; Diet, Atherogenic; Diltiazem; Drug Synergism; Enalapril; Male; Maleates; Mesocricetus; Microscopy, Electron | 1997 |
Objectives of high blood pressure treatment: left ventricular hypertrophy, diastolic function, and coronary reserve.
Topics: Antihypertensive Agents; Arterioles; Bisoprolol; Blood Pressure; Coronary Circulation; Diastole; Diltiazem; Disease Progression; Enalapril; Fibrosis; Heart Ventricles; Hemodynamics; Humans; Hypertension; Hypertrophy, Left Ventricular; Isradipine; Treatment Outcome; Ventricular Dysfunction, Left | 1998 |
Circadian blood pressure changes and cardiac abnormalities in IgA nephropathy.
Topics: Adolescent; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Biopsy; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Calcium Channel Blockers; Circadian Rhythm; Diltiazem; Drug Therapy, Combination; Echocardiography; Enalapril; Female; Glomerulonephritis, IGA; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardial Contraction | 1999 |
Evaluation of a technique of inducing hypertensive renal insufficiency in cats.
Topics: Amlodipine; Analysis of Variance; Animals; Blood Pressure; Blood Pressure Determination; Cat Diseases; Cats; Diltiazem; Enalapril; Heart Rate; Hypertension, Renal; Infarction; Kidney; Ligation; Losartan; Nephrectomy; Renal Insufficiency; Telemetry; Time Factors | 2004 |
Enalapril and diltiazem co-administration and respiratory side effects of enalapril.
Topics: Animals; Bronchoconstriction; Calcium Channel Blockers; Cats; Cough; Diltiazem; Drug Combinations; Enalapril; Female; Guinea Pigs; Male; Muscle, Smooth, Vascular; Severity of Illness Index; Treatment Outcome; Vasodilator Agents | 2005 |
Comparative interaction of few antihypertensive drugs with cyclosporine-A in rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta, Thoracic; Chromatography, High Pressure Liquid; Cyclosporine; Diltiazem; Drug Interactions; Enalapril; Losartan; Male; Olive Oil; Plant Oils; Propranolol; Rats; Rats, Wistar | 2007 |
In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors.
Topics: Angiotensin-Converting Enzyme Inhibitors; Carboxylesterase; Carboxylic Ester Hydrolases; Diltiazem; Drug Interactions; Enalapril; Esters; Humans; Hydrolysis; Inactivation, Metabolic; Indoles; Kinetics; Liver; Microsomes, Liver; Nitrophenols; Prodrugs; Ramipril; Recombinant Proteins; Verapamil | 2014 |
Successful management of hypertrophic cardiomyopathy in a Matschie's tree kangaroo (Dendrolagus matschiei).
Topics: Animals; Animals, Zoo; Cardiomyopathy, Hypertrophic; Diltiazem; Enalapril; Furosemide; Macropodidae; Male | 2015 |
Treatment with enalapril and not diltiazem ameliorated progression of chronic kidney disease in rats, and normalized renal AT1 receptor expression as measured with PET imaging.
Topics: Angiotensin II; Animals; Blood Pressure; Body Weight; Diltiazem; Disease Progression; Enalapril; Gene Expression Regulation; Heart; Kidney; Male; Organ Size; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Regional Blood Flow; Renal Insufficiency, Chronic | 2017 |