Page last updated: 2024-08-23

diltiazem and disopyramide

diltiazem has been researched along with disopyramide in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (12.50)	18.7374
1990's	4 (16.67)	18.2507
2000's	9 (37.50)	29.6817
2010's	8 (33.33)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Keserü, GM	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abe, M; Fujiwara, Y; Hamada, M; Hiwada, K; Matsuoka, H; Ohtani, T; Sekiya, M; Sumimoto, T; Suzuki, M	1
Furuya, H; Goto, Y; Ide, M; Tagawa, R; Tanabe, T; Yoshikawa, H	1
Allessie, MA; Bonke, FI; Kirchhof, CJ	1
Hata, Y; Ichimaru, Y; Kodama, Y; Okamoto, K; Otsuka, K; Ueno, T; Yanaga, T	1
Boudonas, G; Efthymiadis, AP; Lefkos, N; Styliadis, IG; Tsapas, G	1
Liddle, RA; Mangel, AW; Prpic, V; Scott, L	2

Reviews

1 review(s) available for diltiazem and disopyramide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for diltiazem and disopyramide

Article	Year
Intravenous administration of diltiazem in the treatment of supraventricular tachyarrhythmias. Acta cardiologica, 1995, Volume: 50, Issue:2 Topics: Adult; Atrial Fibrillation; Atrial Flutter; Blood Pressure; Diltiazem; Disopyramide; Electrocardiography, Ambulatory; Female; Heart Ventricles; Humans; Infusions, Intravenous; Male; Middle Aged; Tachycardia, Paroxysmal; Tachycardia, Supraventricular	1995

Other Studies

22 other study(ies) available for diltiazem and disopyramide

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Effect of disopyramide on left ventricular diastolic function in patients with hypertrophic cardiomyopathy: comparison with diltiazem. Cardiovascular drugs and therapy, 1992, Volume: 6, Issue:4 Topics: Adult; Aged; Blood Pressure; Cardiomegaly; Cardiomyopathies; Diltiazem; Disopyramide; Echocardiography, Doppler; Female; Heart Rate; Humans; Male; Middle Aged; Ventricular Function, Left	1992
Evaluation of antiarrhythmic drug efficacy using holter electrocardiographic technique. Japanese circulation journal, 1985, Volume: 49, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Coronary Disease; Diltiazem; Disopyramide; Drug Evaluation; Electrocardiography; Female; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Propranolol	1985
Effects of verapamil, diltiazem and disopyramide on sinus function: a comparison with bepridil. European journal of pharmacology, 1989, Feb-07, Volume: 160, Issue:3 Topics: Animals; Bepridil; Diltiazem; Disopyramide; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; In Vitro Techniques; Male; Pyrrolidines; Rabbits; Sinoatrial Node; Verapamil	1989
The usefulness of Holter monitoring in the evaluation of antiarrhythmic drug efficacy for tachycardia. Japanese circulation journal, 1983, Volume: 47, Issue:1 Topics: Adult; Aged; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Diltiazem; Disopyramide; Female; Heart Defects, Congenital; Heart Valve Diseases; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Myocardial Infarction; Procainamide; Tachycardia; Tachycardia, Paroxysmal	1983
Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion. Peptides, 1994, Volume: 15, Issue:8 Topics: Adenosine Triphosphate; Animals; Cell Line; Cholecystokinin; Diltiazem; Disopyramide; Glucose; Homeostasis; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Mice; Mice, Inbred ICR; Potassium Channel Blockers; Potassium Channels	1994
Regulation of cholecystokinin secretion in STC-1 cells by nitric oxide. The American journal of physiology, 1996, Volume: 271, Issue:4 Pt 1 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Line; Cells, Cultured; Cholecystokinin; Diltiazem; Disopyramide; Mice; Nitric Oxide; Nitroprusside; Potassium; Potassium Channel Blockers; Potassium Channels	1996