Page last updated: 2024-08-23

diltiazem and deacetyldiltiazem

diltiazem has been researched along with deacetyldiltiazem in 57 studies

Research

Studies (57)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (31.58)	18.7374
1990's	19 (33.33)	18.2507
2000's	16 (28.07)	29.6817
2010's	4 (7.02)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Finegan, BA; Hussain, MD; Tam, YK	1
Lee, MH; Lee, YH; Shim, CK	1
Bai, SA; Lankford, S; Maskasame, C	1
Chiap, P; Crommen, J; Hubert, P	2
Dimmitt, DC; Elvin, AT; Giesing, DH; Lanman, RC; Yu, DK	1
Derendorf, H; Lefevre, JF; Lopez, LM; Schaefer, HG; Ververs, FF	1
Ito, K; Kurosawa, N; Kurosawa, S; Owada, E; Soeda, H	1
Boucher, S; Caillé, G; Du Souich, P; Lery, L; Lery, N; Pilon, D; Spenard, J; Varin, F; Vezina, M	1
Chow, MS; Zhao, H	1
Boyd, RA; Chin, SK; Don-Pedro, O; Giacomini, KM; Sheiner, LB; Verotta, D; Williams, RL	1
Höglund, P; Nilsson, LG	4
Kawakita, S; Kinoshita, M; Morita, K; Muranishi, S; Nishikawa, S; Ono, T; Shibata, N; Shimakawa, H; Takada, K	1
Bhamra, RK; Holt, DW; Ward, AE	1
Abernethy, DR; Mitchell, JR; Montamat, SC	1
Abernethy, DR; Montamat, SC	1
Grech-Belanger, O; Langlois, S; Leboeuf, E	1
Downing, SJ; Edwards, D; Hollingsworth, M	1
Bjornsson, TD; Ellenbogen, KA; McCarthy, EA; Pritchett, EL; Roark, SF; Smith, MS	1
Kelly, JG; Kinney, CD	1
Abernethy, DR; Schwartz, JB; Todd, EL	1
Besner, JG; Biron, P; Caillé, G; Clozel, JP; Taeymans, Y; Théroux, P	1
Dimmitt, DC; Lacz, JP; Runser, DJ; Wiens, RE	1
Pritchett, EL; Shand, DG; Smith, MS; Verghese, CP	1
Caillé, G; du Souich, P; Homsy, W; Lefebvre, M	1
Abadi, AH; Lopez, LM; Rutledge, DR	1
Abadi, AH; Beaudreau, CA; Lopez, LM; Rutledge, DR	1
Frishman, WH	1
Hutt, V; Jaeger, H; Janik, F; Kappler, J; Maccari, M; Pabst, G; Ravelli, V	1
Coors, C; Schulz, HG; Stache, F	1
Caillé, G; du Souich, P; Homsy, W	1
Dunham, GD; Williamson, KM	1
Koves, EM; Lawrence, K; Mayer, JM	1
Buckley, SJ; Feng, JD; Yeung, PK	1
Christensen, H; Molden, E; Sund, RB	1
Aramayona, JJ; Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C	1
Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C	1
Burm, JP; Choi, JS; Lee, JH	1
Blaschke, G; Chankvetadze, B; Kartozia, I	1
Asberg, A; Christensen, H; Molden, E	1
Choi, JS; Kim, YG	1
Bergan, S; Bøe, GH; Christensen, H; Johansen, PW; Lehne, G; Molden, E; Reubsaet, L; Rootwelt, H; Rugstad, HE	1
Albert, KS; Eradiri, O; Lai, JC; Sista, S	1
Burm, JP; Choi, JS	1
Choi, HJ; Choi, JS	1
Choi, JS; Han, HK	1
Chang, KS; Choi, DH; Choi, JS; Hong, SP	1
Choi, DH; Choi, JS; Hong, SP	1
Choi, JS; Li, C	1
Cho, YA; Choi, DH; Choi, JS	1
Bertrand, N; Bouvet, C; Leroux, JC; Moreau, P	1
Chang, KS; Choi, DH; Chung, JW; Ha, SI; Han, JY; Hong, SP; Koh, YY; Yang, JS	1
Choi, DH; Choi, JS; Li, C	1
Han, HK; Kang, KW; Qiang, F	1

Trials

5 trial(s) available for diltiazem and deacetyldiltiazem

Article	Year
Pharmacokinetics of diltiazem and propranolol when administered alone and in combination. Biopharmaceutics & drug disposition, 1991, Volume: 12, Issue:7 Topics: Adult; Diltiazem; Drug Therapy, Combination; Humans; Male; Propranolol; Tablets	1991
Influence of food on the bioavailability of diltiazem and two of its metabolites following the administration of conventional tablets and slow-release capsules. Biopharmaceutics & drug disposition, 1990, Volume: 11, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Delayed-Action Preparations; Diltiazem; Drug Administration Schedule; Food; Humans; Male; Middle Aged	1990
A new extended-release formulation of diltiazem HCl for the treatment of mild-to-moderate hypertension. Journal of clinical pharmacology, 1993, Volume: 33, Issue:7 Topics: Blood Pressure; Capsules; Clinical Trials as Topic; Delayed-Action Preparations; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Female; Food; Humans; Hypertension; Male; Middle Aged; Retrospective Studies	1993
Evaluation of pharmacokinetics, bioavailability and dose linearity of diltiazem in healthy volunteers. Arzneimittel-Forschung, 1993, Volume: 43, Issue:7 Topics: Adolescent; Adult; Biological Availability; Chromatography, High Pressure Liquid; Diltiazem; Humans; Male; Middle Aged; Spectrophotometry, Ultraviolet	1993
Pharmacokinetics of a novel diltiazem HCl extended-release tablet formulation for evening administration. Journal of clinical pharmacology, 2003, Volume: 43, Issue:10 Topics: Adult; Biological Availability; Chronotherapy; Circadian Rhythm; Cross-Over Studies; Delayed-Action Preparations; Diltiazem; Doxepin; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pharmacokinetics; Tablets	2003

Other Studies

52 other study(ies) available for diltiazem and deacetyldiltiazem

Article	Year
Pharmacokinetics of diltiazem in patients undergoing coronary artery bypass grafting. Therapeutic drug monitoring, 1992, Volume: 14, Issue:6 Topics: Administration, Oral; Aged; Coronary Artery Bypass; Diltiazem; Female; Humans; Male; Middle Aged; Preoperative Care	1992
Decreased systemic clearance of diltiazem with increased hepatic metabolism in rats with uranyl nitrate-induced acute renal failure. Pharmaceutical research, 1992, Volume: 9, Issue:12 Topics: Acute Kidney Injury; Animals; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Diltiazem; Injections, Intravenous; Liver; Liver Circulation; Male; Portal Vein; Protein Binding; Rats; Rats, Wistar; Uranyl Nitrate	1992
The effects of chronic oral diltiazem and cimetidine dosing on the pharmacokinetics and negative dromotropic action of intravenous and oral diltiazem in the dog. Biopharmaceutics & drug disposition, 1992, Volume: 13, Issue:7 Topics: Administration, Oral; Animals; Blood Proteins; Cimetidine; Depression, Chemical; Diltiazem; Dogs; Drug Administration Schedule; Drug Interactions; Female; Infusions, Intravenous; Neural Conduction; Protein Binding	1992
Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC--Part I: Optimization of the HPLC system and method validation. Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:10-12 Topics: Automation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity	1991
Automatic determination of diltiazem and desacetyldiltiazem in human plasma using liquid-solid extraction on disposable cartridges coupled to HPLC--Part II: Optimization of liquid-solid extraction. Journal of pharmaceutical and biomedical analysis, 1991, Volume: 9, Issue:10-12 Topics: Automation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Hydrogen-Ion Concentration; Reference Standards; Solutions; Water	1991
Simultaneous assay of propranolol, diltiazem and metabolites of diltiazem in human plasma by liquid chromatography. Journal of pharmaceutical and biomedical analysis, 1990, Volume: 8, Issue:6 Topics: Biotransformation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Male; Propranolol; Spectrophotometry, Ultraviolet	1990
Pharmacokinetics of diltiazem in patients with liver cirrhosis. International journal of clinical pharmacology research, 1990, Volume: 10, Issue:6 Topics: Adult; Aged; Biotransformation; Chromatography, High Pressure Liquid; Creatinine; Delayed-Action Preparations; Diltiazem; Female; Half-Life; Humans; Liver Cirrhosis; Male; Middle Aged; Regression Analysis	1990
Analysis of diltiazem and desacetyldiltiazem in plasma using modified high-performance liquid chromatography: improved sensitivity and reproducibility. Pharmaceutical research, 1989, Volume: 6, Issue:5 Topics: Cardiovascular Agents; Chromatography, High Pressure Liquid; Diltiazem; Humans; Spectrophotometry, Ultraviolet	1989
The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose. Clinical pharmacology and therapeutics, 1989, Volume: 46, Issue:4 Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Diltiazem; Half-Life; Humans; Male; Protein Binding	1989
Pharmacokinetics of diltiazem and its metabolites after repeated multiple-dose treatments in healthy volunteers. Therapeutic drug monitoring, 1989, Volume: 11, Issue:5 Topics: Adult; Biotransformation; Blood Chemical Analysis; Diltiazem; Feces; Female; Half-Life; Humans; Middle Aged; Reference Values	1989
Pharmacokinetics of diltiazem and its metabolites after repeated single dosing in healthy volunteers. Therapeutic drug monitoring, 1989, Volume: 11, Issue:5 Topics: Adult; Chromatography, High Pressure Liquid; Diltiazem; Female; Half-Life; Humans; Male; Middle Aged	1989
Pharmacokinetics of diltiazem and its metabolites after single and multiple dosing in healthy volunteers. Therapeutic drug monitoring, 1989, Volume: 11, Issue:5 Topics: Administration, Oral; Adult; Biotransformation; Capsules; Diltiazem; Feces; Female; Half-Life; Humans; Male; Middle Aged; Reference Values	1989
Physiological disposition of intravenously administered 14C-labeled diltiazem in healthy volunteers. Therapeutic drug monitoring, 1988, Volume: 10, Issue:4 Topics: Adult; Blood Pressure; Diltiazem; Electrocardiography; Female; Half-Life; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Scintillation Counting	1988
Effects of diltiazem on rheological properties of human blood. Journal of pharmacobio-dynamics, 1988, Volume: 11, Issue:3 Topics: Adenosine Triphosphate; Blood Platelets; Blood Viscosity; Diltiazem; Erythrocyte Deformability; Erythrocytes; Humans; In Vitro Techniques; Injections, Intravenous; Middle Aged; Osmotic Fragility; Pentoxifylline	1988
HPLC measurement of diltiazem and desacetyldiltiazem in serum or plasma. Biomedical chromatography : BMC, 1987, Volume: 2, Issue:4 Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Diltiazem; Humans	1987
High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma. Journal of chromatography, 1987, Mar-20, Volume: 415, Issue:1 Topics: Aged; Biotransformation; Chromatography, High Pressure Liquid; Diltiazem; Humans; Hypertension; Kinetics; Male; Spectrophotometry, Ultraviolet	1987
N-monodesmethyldiltiazem is the predominant metabolite of diltiazem in the plasma of young and elderly hypertensives. British journal of clinical pharmacology, 1987, Volume: 24, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Biotransformation; Diltiazem; Female; Half-Life; Humans; Hypertension; Kinetics; Male	1987
Assay of diltiazem and deacetyldiltiazem by capillary gas chromatography. Journal of chromatography, 1987, Jun-05, Volume: 417, Issue:1 Topics: Biotransformation; Chromatography, Gas; Diltiazem; Drug Stability; Humans; Hydrogen-Ion Concentration; Kidney Failure, Chronic; Kinetics	1987
Diltiazem pharmacokinetics in the rat and relationship between its serum concentration and uterine and cardiovascular effects. British journal of pharmacology, 1987, Volume: 91, Issue:4 Topics: Animals; Chromatography, High Pressure Liquid; Diltiazem; Dose-Response Relationship, Drug; Female; Hemodynamics; Infusions, Intravenous; Injections, Intravenous; Ovariectomy; Pregnancy; Rats; Uterine Contraction	1987
Effects of sustained intravenous diltiazem infusion in healthy persons. The American journal of cardiology, 1986, Nov-15, Volume: 58, Issue:11 Topics: Adult; Atrioventricular Node; Blood Pressure; Diltiazem; Electrocardiography; Humans; Infusions, Intravenous; Kinetics; Male	1986
Estimation of concentrations of diltiazem in plasma using normal-phase column liquid chromatography with ultraviolet detection. Journal of chromatography, 1986, Oct-31, Volume: 382 Topics: Chromatography, Liquid; Diltiazem; Humans; Spectrophotometry, Ultraviolet	1986
Diltiazem and desacetyldiltiazem analysis in human plasma using high-performance liquid chromatography: improved sensitivity without derivation. Journal of chromatography, 1985, Jul-12, Volume: 342, Issue:1 Topics: Adult; Benzazepines; Chromatography, High Pressure Liquid; Desipramine; Diltiazem; Female; Half-Life; Humans; Kinetics	1985
Improved gas chromatographic determination of diltiazem and deacetyldiltiazem in human plasma. Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:2 Topics: Benzazepines; Biological Availability; Chromatography, Gas; Diltiazem; Humans; Kinetics	1984
Quantitation of diltiazem and desacetyldiltiazem in dog plasma by high-performance liquid chromatography. Journal of pharmaceutical sciences, 1984, Volume: 73, Issue:5 Topics: Animals; Benzazepines; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Dogs; Drug Stability; Hydrogen-Ion Concentration; Kinetics	1984
Pharmacokinetic and pharmacodynamic effects of diltiazem. The American journal of cardiology, 1983, May-01, Volume: 51, Issue:8 Topics: Administration, Oral; Adult; Benzazepines; Diltiazem; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged; Myocardial Contraction	1983
Metabolism of diltiazem in hepatic and extrahepatic tissues of rabbits: in vitro studies. Pharmaceutical research, 1995, Volume: 12, Issue:4 Topics: Animals; Diltiazem; In Vitro Techniques; Intestinal Mucosa; Kidney; Liver; Male; Rabbits	1995
Liquid chromatographic determination of celiprolol, diltiazem, desmethyldiltiazem and deacetyldiltiazem in plasma using a short alkyl chain silanol deactivated column. Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:1 Topics: Celiprolol; Chromatography, High Pressure Liquid; Diltiazem; Humans; Reference Standards; Reproducibility of Results; Silanes	1994
High-performance liquid chromatographic determination of diltiazem and two of its metabolites in plasma using a short alkyl chain silanol deactivated column. Journal of chromatography, 1993, May-19, Volume: 615, Issue:1 Topics: Chromatography, High Pressure Liquid; Diltiazem; Humans; Hypertension; Indicators and Reagents; Male; Silanes; Spectrophotometry, Ultraviolet	1993
Development and validation of a bioanalytical method for the quantification of diltiazem and desacetyldiltiazem in plasma by capillary zone electrophoresis. Journal of chromatography. A, 1995, Nov-24, Volume: 717, Issue:1-2 Topics: Calcium Channel Blockers; Diltiazem; Electrophoresis, Capillary; Humans; Reference Standards; Reproducibility of Results; Verapamil	1995
The site of absorption in the small intestine determines diltiazem bioavailability in the rabbit. Pharmaceutical research, 1995, Volume: 12, Issue:11 Topics: Animals; Biological Availability; Biotransformation; Blood Gas Analysis; Calcium Channel Blockers; Diltiazem; Half-Life; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Male; Rabbits	1995
Plasma concentrations of diltiazem and desacetyldiltiazem in an overdose situation. The Annals of pharmacotherapy, 1996, Volume: 30, Issue:6 Topics: Adolescent; Antidotes; Biotransformation; Calcium Channel Blockers; Charcoal; Diltiazem; Female; Humans; Suicide, Attempted	1996
Stability of diltiazem in whole blood: forensic implications. Journal of forensic sciences, 1998, Volume: 43, Issue:3 Topics: Adult; Cardiovascular Agents; Chromatography, High Pressure Liquid; Diltiazem; Drug Stability; Fatal Outcome; Female; Forensic Medicine; Humans; Male; Middle Aged; Postmortem Changes; Reproducibility of Results; Suicide; Temperature; Time Factors	1998
Pharmacokinetics and hypotensive effect of diltiazem in rabbits: comparison of diltiazem with its major metabolites. The Journal of pharmacy and pharmacology, 1998, Volume: 50, Issue:11 Topics: Animals; Antihypertensive Agents; Blood Pressure; Chromatography, High Pressure Liquid; Diltiazem; Dose-Response Relationship, Drug; Female; Hypertension; Injections, Intravenous; Molecular Structure; Rabbits	1998
Extensive metabolism of diltiazem and P-glycoprotein-mediated efflux of desacetyl-diltiazem (M1) by rat jejunum in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Biological Transport; Biotransformation; Calcium Channel Blockers; Dealkylation; Diltiazem; Hydrolysis; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Rats; Rats, Wistar	2000
Diltiazem blood pharmacokinetics in the pregnant and non-pregnant rabbit: maternal and foetal tissue levels. Xenobiotica; the fate of foreign compounds in biological systems, 2000, Volume: 30, Issue:8 Topics: Animals; Antihypertensive Agents; Brain; Diltiazem; Female; Fetal Blood; Fetus; Injections, Intravenous; Kidney; Kinetics; Maternal-Fetal Exchange; Muscles; Placenta; Pregnancy; Pregnancy, Animal; Regression Analysis; Tissue Distribution; Uterus	2000
Altered diltiazem metabolism in the neonatal rabbit following intra-uterine chronic exposure to diltiazem. Xenobiotica; the fate of foreign compounds in biological systems, 2001, Volume: 31, Issue:4 Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Brain; Chromatography, High Pressure Liquid; Diltiazem; Female; Intestinal Mucosa; Liver; Lung; Maternal Exposure; Pregnancy; Rabbits; Time Factors; Tissue Distribution	2001
Pharmacokinetics of diltiazem and its major metabolite, deacetyidiltiazem after oral administration of diltiazem in mild and medium folate-induced renal failure rabbits. Archives of pharmacal research, 2001, Volume: 24, Issue:4 Topics: Acute Kidney Injury; Animals; Area Under Curve; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Folic Acid; Male; Rabbits	2001
Simultaneous enantioseparation of cis-diltiazem hydrochloride and its metabolite cis-desacetyldiltiazem using high-performance liquid chromatography and capillary electrophoresis. Journal of pharmaceutical and biomedical analysis, 2002, Jan-01, Volume: 27, Issue:1-2 Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Electrophoresis, Capillary; Mass Spectrometry; Molecular Structure; Stereoisomerism	2002
Desacetyl-diltiazem displays severalfold higher affinity to CYP2D6 compared with CYP3A4. Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:1 Topics: Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Hepatocytes; Humans; Mixed Function Oxygenases	2002
Pharmacokinetic changes of diltiazem and desacetyldiltiazem after oral administration of diltiazem in rabbits with diabetes mellitus induced by alloxan. Biopharmaceutics & drug disposition, 2002, Volume: 23, Issue:3 Topics: Administration, Oral; Alloxan; Animals; Area Under Curve; Diabetes Mellitus, Experimental; Diltiazem; Male; Rats	2002
Pharmacokinetics of diltiazem and its metabolites in relation to CYP2D6 genotype. Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:3 Topics: Area Under Curve; Calcium Channel Blockers; Cytochrome P-450 CYP2D6; Diltiazem; Female; Genotype; Humans; Male	2002
The influence of cimetidine on the pharmacokinetics of diltiazem and its main metabolite in rabbits. Archives of pharmacal research, 2004, Volume: 27, Issue:2 Topics: Algorithms; Animals; Anti-Ulcer Agents; Area Under Curve; Biotransformation; Calcium Channel Blockers; Cimetidine; Diltiazem; Drug Interactions; Half-Life; Male; Rabbits	2004
Effects of morin pretreatment on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem in rats. Archives of pharmacal research, 2005, Volume: 28, Issue:8 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Dietary Supplements; Diltiazem; Drug Interactions; Flavonoids; Intestinal Absorption; Male; Models, Animal; Rats; Rats, Sprague-Dawley	2005
Enhanced oral exposure of diltiazem by the concomitant use of naringin in rats. International journal of pharmaceutics, 2005, Nov-23, Volume: 305, Issue:1-2 Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Flavanones; Male; Rats; Rats, Sprague-Dawley	2005
Effect of atorvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. Archives of pharmacal research, 2007, Volume: 30, Issue:1 Topics: Administration, Oral; Animals; Area Under Curve; Atorvastatin; Biological Availability; Biotransformation; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Male; Metabolic Clearance Rate; Pyrroles; Rats; Rats, Sprague-Dawley	2007
Effects of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem, in rats. Cardiovascular therapeutics, 2008,Winter, Volume: 26, Issue:4 Topics: Administration, Oral; Analysis of Variance; Animals; Antioxidants; Area Under Curve; Biological Availability; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes	2008
Effects of epigallocatechin gallate on the bioavailability and pharmacokinetics of diltiazem in rats. Die Pharmazie, 2008, Volume: 63, Issue:11 Topics: Administration, Oral; Animals; Biological Availability; Calcium Channel Blockers; Catechin; Chromatography, High Pressure Liquid; Diltiazem; Half-Life; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley	2008
Effect of hesperidin on the oral pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:6 Topics: Administration, Oral; Animals; Antioxidants; Area Under Curve; Biological Availability; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Hesperidin; Male; Rats; Rats, Sprague-Dawley	2009
Transmembrane pH-gradient liposomes to treat cardiovascular drug intoxication. ACS nano, 2010, Dec-28, Volume: 4, Issue:12 Topics: Animals; Calcium Channel Blockers; Cell Membrane; Chemistry, Pharmaceutical; Diltiazem; Hydrogen-Ion Concentration; Hypotension; Liposomes; Male; Polyethylene Glycols; Rats; Rats, Sprague-Dawley	2010
Effects of lovastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by lovastatin. The Journal of pharmacy and pharmacology, 2011, Volume: 63, Issue:1 Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Rats; Rats, Sprague-Dawley	2011
Effects of simvastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, after oral and intravenous administration in rats: possible role of P-glycoprotein and CYP3A4 inhibition by simvastatin. Pharmacological reports : PR, 2011, Volume: 63, Issue:6 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Infusions, Intravenous; Male; Rats; Rats, Sprague-Dawley; Simvastatin	2011
Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats. Biopharmaceutics & drug disposition, 2012, Volume: 33, Issue:8 Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Availability; Calcium Channel Blockers; Diltiazem; Food-Drug Interactions; Gene Expression; Hep G2 Cells; Humans; Male; Piperidines; Polyunsaturated Alkamides; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Steroid	2012