Page last updated: 2024-08-23

diltiazem and cyclosporine

diltiazem has been researched along with cyclosporine in 113 studies

Research

Studies (113)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	62 (54.87)	18.2507
2000's	31 (27.43)	29.6817
2010's	17 (15.04)	24.3611
2020's	3 (2.65)	2.80

Authors

Authors	Studies
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Müller, H; Pick, A; Wiese, M	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Globisch, C; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bauer, S; Brockmöller, J; Kewitz, H; Roots, I	1
Kunzendorf, U; Neumayer, HH; Schreiber, M	2
Connell, J; Harvison, A; Keogh, A; Macdonald, P; Richens, D; Spratt, P	1
Freeman, D; Keown, P; McDonald, J; Petric, R; Stiller, C; Wallace, C	1
Bergström, C; Fellström, B; Frödin, L; Hanås, E; Skarp-Orberg, I; Wahlberg, J	1
Alcaraz, A; Andreu, J; Campistol, JM; Fernandez-Cruz, L; Mañalich, M; Oppenheimer, F; Ricart, MJ; Talbot-Wright, R; Vilardell, J	1
Hunt, CM; Stave, GM; Westerkam, WR	1
Carrier, M; Pelletier, LC; Stewart, D; Tronc, F	1
Hartz, PA; Wilson, PD	1
Solem, LE; Wallace, KB	1
Baysal, K; Brierley, GP; Jung, DW	1
Reams, GP	1
Belitsky, P; Knox, MG; Methot, ME; Nicol, D; Sketris, IS	1
Adamczyk, M; Auch-Schwelk, W; Bossaller, C; Brodde, OE; Busch, F; Duske, E; Fleck, E; Götze, S	1
Gough, J; Jeffery, JR; Rush, DN	1
Carozzi, S; Fontana, I; Nasini, MG; Nocera, A; Pietrucci, A; Valente, U	1
Baraldo, M; Furlanut, M; Puricelli, C	1
Jacobs, U; Klehr, HU; Klein, B	1
Cooke, CE	1
Kudoh, S; Satoh, A	1
Auch-Schwelk, W; Bossaller, C; Fleck, E; Götze, S; Thelen, J	2
Becker, GJ; Choy, BY; Walker, RG	1
Dhawan, I; Masri, MA; Pingle, A; Shakuntala, V; Shanwaz, M; Yasin, I; Zaher, M	1
Brunson, ME; Howard, RJ; Karlix, JL; Patton, PR; Peterson, JC; Pfaff, WW; Ramos, EL	1
Chen, H; Daloze, P; Dumont, L; Garceau, D; Xu, D	1
Cardella, CJ; Leenen, FH; Legault, L; Ogilvie, RI	1
Carrier, M; Nattel, S; Pelletier, LC; Stewart, D; Tronc, F	1
Chrysostomou, A; d'Apice, AJ; Kincaid-Smith, P; Mathew, TH; Russ, GR; Walker, RG	1
Francis, DM; Fullinfaw, R; Higgins, TJ; King, GN; Walker, RG; Wiesenfeld, D	1
Bourge, R; Brozena, SC; Clemson, B; Hobbs, R; Johnson, MR; Miller, L; Mills, RM; Naftel, D; Olivari, MT; Quigg, R; Ventura, H	1
Bader, A; Bleck, JS; Christians, U; Kliem, V; Lampen, A; Manns, M; Repp, H; Sewing, KF; Thiesemann, C; Westhoff-Bleck, M	1
Bleck, JS; Christians, U; Frei, U; Hecker, H; Kliem, V; Manns, M; Repp, H; Sewing, KF; Thiesemann, C; Westhoff-Bleck, M	1
Aydin, AE; Aygün, S; Carin, M; Cebeci, I; Firatli, E; Güç, U; Kantarci, A; Tanyeri, H; Tuncer, O	1
Jones, TE; Morris, RG	2
Jones, TE	2
Keiser, HR; Oriji, GK	1
Jones, TE; Mathew, TH; Morris, RG	2
al Edreesi, M; Caillé, G; Dupuis, C; Paradis, K; Théoret, Y	1
Andersen, RC; Dahl, DC; Goerdt, PJ; Heim-Duthoy, KL; Jacobs, DM; Johnson, HJ; Kasiske, BL; Ney, AL; Odland, MD; Rao, VK	1
Saris, NE	1
D'Ambrosio, A; Quintieri, F; Segoloni, G	1
Christians, U; Korn, A; Sperschneider, H; Wagner, C	1
Figueira, ER; Leitão, RM; Massarollo, PC; Mies, S; Raia, S	1
McLachlan, AJ; Tett, SE	1
Ardiles, L; Elberg, A; Flores, C; Foradori, A; Mezzano, S	1
Elberg, A; Foradori, A; Mezzano, S; Pefaur, J; Videla, C	1
Eichinger, H; Lehle, K; Preuner, JG; Rupprecht, L	1
Balogh, A; Fleck, C; Kostka, E; Kühl, A; Kuhn, UD; Lupp, A; Stein, G	1
Asberg, A; Berg, KJ; Christensen, H; Hartmann, A	1
Cartier, R; Demers, P; Elkouri, S; Mathieu, P	1
Chan, L; Jacob, LP; Malhotra, D; Shapiro, JI	1
Chen, H; Daloze, P; Dumont, L; Lapointe, N; Qi, S; Xu, D	1
Asberg, A; Berg, KJ; Carlson, E; Christensen, H; Schram, L	1
Huang, W; Jiang, TT; Patel, D	1
Asberg, A; Berg, KJ; Carlson, E; Christensen, H; Hartmann, A; Molden, E	1
Oriji, GK	1
Carrier, M; Daly, P; Davies, R; Gudas, V; Kostuk, W; Latter, D; Rivard, M; Sullivan, J; Teo, K; White, M	1
Amano, A; Daikoku, H; Fujimori, Y; Fukui, N; Morisaki, I; Murakami, J	1
Landwojtowicz, E; Seelig, A	1
Akhlaghi, F; Kaan, A; Keogh, AM; McLachlan, AJ	1
Chen, HC; Chen, YL; Cheng, CH; Hsieh, CL; Shu, KH	1
McDonald, SP; Russ, GR	1
Dietl, KH	1
Cook, S; Cooke, R; Fullinfaw, RO; Ilett, KF; Morris, RG; Ray, JE; Tett, SE	1
Fox, DA; Harris, JB; He, L; Medrano, CJ; Poblenz, AT	1
Cea-Calvo, L; de la Calzada, CS; de la Cámara, AG; Delgado, JF; Escribano, P; Gómez-Sánchez, MA; Pascual, JG; Rufilanchas, JJ; Sánchez, V; Sotelo, T	1
Akhlaghi, F; Keogh, AM; McLachlan, AJ; Ray, JE	1
Chan, TM; Haycox, A; Kou, M; Kumana, CR; Lauder, IJ; Lee, JS; Li, CS; Tong, MK; Walley, T	1
Cheranov, SY; Jaggar, JH	1
Alruiz, PA; Ardiles, LG; Aros, CA; Flores, CA; Jerez, V; Mezzano, SA; Schneider, HO	1
Alruiz, PA; Ardiles, LG; Aros, CA; Flores, CA; Jerez, VR; Mezzano, SA; Schneider, HO	1
Asahi, S; Katoh, M; Suzuyama, N; Takeuchi, T; Yokoi, T; Yoshitomi, S	1
Bunnag, S; Ong-ajyooth, L; Vareesangthip, K	1
Chalermsanyakorn, P; Ingsathit, A; Jirasiritham, S; Sumethkul, V	1
Keogh, AM; McLachlan, AJ; Ray, JE	1
Inamdar, MN; Kumar, NP; Venkataraman, BV	1
Chen, LQ; Chen, LZ; Chen, YH; Hu, JB; Li, WL; Liang, JJ; Liang, YX; Qiu, J; Xie, KJ; Zhang, J; Zheng, KL; Zhong, WD	1
Bi, H; Chen, X; Huang, M; Li, J; Wang, C; Wang, X; Wang, Y; Zhu, G	1
Colucci, M; D'Ambrosio, A; Giordani, L; Quintieri, F; Vanacore, N	1
Dönmez, O; Durmaz, O	1
Ding, X; Feng, X; Hou, J; Pan, X; Tian, P; Tian, X; Xiang, H; Xue, W; Yan, H	1
Ding, X; Fan, X; Feng, X; Hou, J; Pan, X; Qin, G; Song, Y; Tian, P; Tian, X; Xiang, H; Xue, W; Yan, H	1
Atteno, M; Cantarini, L; Caso, F; Costa, L; Cozzi, F; Punzi, L; Scarpa, R; Sfriso, P	1
Huang, M; Li, JL; Wang, CX; Wang, XD; Wang, YX; Zhang, Y	1
Shalaby, U	1
Chen, L; Chen, Y; Lei, W; Li, M; Liang, J; Lin, Y; Lu, Y; Yang, J; Zhang, J; Zhang, Z	1
Kurniawan, MZ; Lusida, M; Nugroho, J	1
Bacon, S; Croker, R; Curtis, HJ; Goldacre, B; MacKenna, B; Walker, AJ	1
Alyaydin, E; Reinecke, H; Sindermann, JR; Tuleta, I	1

Reviews

3 review(s) available for diltiazem and cyclosporine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Do calcium channel blockers have renal protective effects? Drugs & aging, 1994, Volume: 5, Issue:4 Topics: Aging; Animals; Calcium Channel Blockers; Clinical Trials as Topic; Cyclosporine; Diabetic Nephropathies; Dihydropyridines; Diltiazem; Disease Models, Animal; Glomerular Filtration Rate; Hemodynamics; Humans; Hypertension, Renal; Kidney; Kidney Transplantation; Rats; Rats, Inbred SHR; Verapamil	1994
The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations. Clinical pharmacokinetics, 1997, Volume: 32, Issue:5 Topics: Aryl Hydrocarbon Hydroxylases; Australia; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Synergism; Enzyme Inhibitors; Graft Rejection; Humans; Immunosuppressive Agents; Ketoconazole; New Zealand; Organ Transplantation; Oxidoreductases, N-Demethylating	1997

Trials

25 trial(s) available for diltiazem and cyclosporine

Article	Year
Protective effects of calcium antagonists in human renal transplantation. Kidney international. Supplement, 1992, Volume: 36 Topics: Acute Kidney Injury; Adult; Creatinine; Cyclosporine; Diltiazem; Graft Rejection; Humans; Iloprost; Kidney Transplantation; Middle Aged; Prospective Studies	1992
Protective effects of diltiazem and the prostazycline analogue iloprost in human renal transplantation. Renal failure, 1992, Volume: 14, Issue:3 Topics: Acute Kidney Injury; Adult; Cyclosporine; Diltiazem; Follow-Up Studies; Graft Survival; Humans; Iloprost; Immunosuppression Therapy; Kidney Transplantation; Middle Aged; Organ Preservation; Prospective Studies	1992
Diltiazem co-administration reduces cyclosporine toxicity after heart transplantation: a prospective randomised study. Transplantation proceedings, 1992, Volume: 24, Issue:5 Topics: Actuarial Analysis; Adult; Cyclosporine; Diltiazem; Female; Follow-Up Studies; Graft Rejection; Heart Transplantation; Humans; Male; Prospective Studies; Survival Analysis; Time Factors	1992
Diltiazem treatment with reduced dose of cyclosporine in renal transplant recipients. Transplantation proceedings, 1992, Volume: 24, Issue:1 Topics: Azathioprine; Creatinine; Cyclosporine; Diltiazem; Drug Administration Schedule; Graft Rejection; Humans; Immunosuppression Therapy; Kidney Function Tests; Kidney Transplantation; Prednisolone; Prospective Studies	1992
Influence of the calcium blocker diltiazem on the prevention of acute renal failure after renal transplantation. Transplantation proceedings, 1992, Volume: 24, Issue:1 Topics: Adult; Cyclosporine; Diltiazem; Female; Follow-Up Studies; Graft Rejection; Humans; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Male; Probability; Time Factors	1992
Sequential protocol biopsies in renal transplant patients: repeated inflammation is associated with impaired graft function at 1 year. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Adult; Biopsy, Needle; Cyclosporine; Diltiazem; Follow-Up Studies; Graft Rejection; Histocompatibility Testing; Humans; Immunosuppressive Agents; Inflammation; Kidney Transplantation; Predictive Value of Tests; Time Factors	1995
Immunosuppressive effects of different calcium channel blockers in human kidney allografts. Transplantation proceedings, 1995, Volume: 27, Issue:1 Topics: Calcium; Calcium Channel Blockers; Cyclosporine; Cytokines; Diltiazem; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Isradipine; Kidney Transplantation; Lymphocytes; Prednisolone; Transplantation, Homologous; Verapamil	1995
A preliminary report of diltiazem and ketoconazole. Their cyclosporine-sparing effect and impact on transplant outcome. Transplantation, 1994, Mar-27, Volume: 57, Issue:6 Topics: Adult; Blood Pressure; Costs and Cost Analysis; Creatinine; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Female; Graft Rejection; Humans; Ketoconazole; Kidney; Kidney Transplantation; Male; Middle Aged; Treatment Outcome	1994
Calcium antagonists in heart transplant recipients: effects on cardiac and renal function and cyclosporine pharmacokinetics. The Canadian journal of cardiology, 1993, Volume: 9, Issue:5 Topics: Cyclosporine; Diltiazem; Heart Transplantation; Hemodynamics; Humans; Hypertension; Immunosuppression Therapy; Kidney; Kidney Function Tests; Male; Middle Aged; Nifedipine	1993
Diltiazem in renal allograft recipients receiving cyclosporine. Transplantation, 1993, Volume: 55, Issue:2 Topics: Adult; Blood Pressure; Cyclosporine; Diltiazem; Drug Therapy, Combination; Female; Graft Rejection; Humans; Kidney Transplantation; Male; Middle Aged; Transplantation, Homologous	1993
Effectiveness and safety of diltiazem or lisinopril in treatment of hypertension after heart transplantation. Results of a prospective, randomized multicenter trail. Journal of the American College of Cardiology, 1996, Volume: 27, Issue:7 Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Cyclosporine; Diltiazem; Female; Heart Transplantation; Humans; Hypertension; Immunosuppressive Agents; Lisinopril; Male; Middle Aged; Postoperative Complications; Prospective Studies; Treatment Outcome	1996
Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients. British journal of clinical pharmacology, 1996, Volume: 41, Issue:6 Topics: Adult; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cyclosporine; Diltiazem; Female; Half-Life; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Sex Factors	1996
Formulation of diltiazem affects cyclosporin-sparing activity. European journal of clinical pharmacology, 1997, Volume: 52, Issue:1 Topics: Adult; Antihypertensive Agents; Child; Cyclosporine; Delayed-Action Preparations; Diffusion; Diltiazem; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged	1997
Safety, tolerability, and pharmacokinetic actions of diltiazem in pediatric liver transplant recipients on cyclosporine. Liver transplantation and surgery : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 1995, Volume: 1, Issue:6 Topics: Adolescent; Calcium Channel Blockers; Child; Child, Preschool; Creatinine; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Glomerular Filtration Rate; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Liver; Liver Transplantation; Male; Prospective Studies; Safety; Treatment Outcome	1995
A randomized trial comparing cyclosporine induction with sequential therapy in renal transplant recipients. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1997, Volume: 30, Issue:5 Topics: Adult; Antilymphocyte Serum; Cadaver; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Therapy, Combination; Feasibility Studies; Female; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Incidence; Kidney Transplantation; Male; Middle Aged; Pilot Projects; Prospective Studies; T-Lymphocytes; Time Factors	1997
[Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients]. Medizinische Klinik (Munich, Germany : 1983), 1997, Oct-15, Volume: 92, Issue:10 Topics: Adult; Biotransformation; Calcium Channel Blockers; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Nifedipine; Prospective Studies; Structure-Activity Relationship	1997
Study of neoral kinetics in adult renal transplantation treated with diltiazem. Transplantation proceedings, 1998, Volume: 30, Issue:5 Topics: Administration, Oral; Adult; Calcium Channel Blockers; Cyclosporine; Diltiazem; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Metabolic Clearance Rate; Middle Aged; Time Factors	1998
Modification of the pharmacokinetics of cyclosporine A and metabolites by the concomitant use of Neoral and diltiazem or ketoconazol in stable adult kidney transplants. Transplantation proceedings, 1998, Volume: 30, Issue:5 Topics: Administration, Oral; Adult; Antifungal Agents; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Half-Life; Humans; Immunosuppressive Agents; Ketoconazole; Kidney Transplantation; Regression Analysis	1998
A simple and sensitive high-performance liquid chromatography assay of diltiazem and main metabolites in renal transplanted patients. Clinica chimica acta; international journal of clinical chemistry, 1999, Volume: 283, Issue:1-2 Topics: Adult; Aged; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cyclosporine; Diltiazem; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Sensitivity and Specificity	1999
Oral dosing of tacrolimus and cyclosporine microemulsion--results from a large multicenter study in renal transplantation. Transplantation proceedings, 2002, Volume: 34, Issue:5 Topics: Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Emulsions; Europe; Female; Humans; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Survival Analysis; Tacrolimus	2002
Diltiazem co-treatment in renal transplant patients receiving microemulsion cyclosporin. British journal of clinical pharmacology, 2003, Volume: 56, Issue:6 Topics: Adolescent; Adult; Aged; Cost Savings; Cyclosporine; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Quality of Life; Transplantation, Homologous; Treatment Outcome	2003
Correlation Between C2 and AUC(0-4) in Renal Transplant Patients Treated With Diltiazem. Transplantation proceedings, 2005, Volume: 37, Issue:3 Topics: Adult; Aged; Area Under Curve; Cyclosporine; Diltiazem; Drug Monitoring; Humans; Immunosuppressive Agents; Kidney Transplantation; Middle Aged; Vasodilator Agents	2005
No gender-associated differences of cyclosporine pharmacokinetics in stable renal transplant patients treated with diltiazem. Transplantation proceedings, 2005, Volume: 37, Issue:8 Topics: Area Under Curve; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Sex Characteristics	2005
Combination therapy with diltiazem plus CsA/MMF/Pred or CsA/Aza/Pred triple immunosuppressive regimens for use in clinical kidney transplantation in Northwestern China. European journal of clinical pharmacology, 2011, Volume: 67, Issue:6 Topics: Adolescent; Adult; Aged; Azathioprine; Cohort Studies; Cyclosporine; Diltiazem; Drug Combinations; Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Function Tests; Kidney Transplantation; Liver Function Tests; Male; Middle Aged; Mycophenolic Acid; Prednisolone; Young Adult	2011
Diltiazem co treatment with cyclosporine for induction of disease remission in sight-threatening non-infectious intraocular inflammation. Japanese journal of ophthalmology, 2017, Volume: 61, Issue:2 Topics: Adult; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Aged; Prospective Studies; Remission Induction; Uveitis; Vasodilator Agents	2017

Other Studies

85 other study(ies) available for diltiazem and cyclosporine

Article	Year
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
New functional assay of P-glycoprotein activity using Hoechst 33342. Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23 Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2). Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17 Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Models, Molecular; Molecular Structure; Neoplasm Proteins; Phthalic Acids; Quantitative Structure-Activity Relationship; Quinolines; Reproducibility of Results; Stereoisomerism; Time Factors; Tumor Cells, Cultured	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Synthesis and biological evaluation of a small molecule library of 3rd generation multidrug resistance modulators. Bioorganic & medicinal chemistry, 2009, Mar-15, Volume: 17, Issue:6 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dogs; Drug Resistance, Multiple; Magnetic Resonance Spectroscopy; Models, Molecular	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment. Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10 Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The effect of the new immunosuppressive drug FK506 on the formation of secondary metabolites of cyclosporin A. International journal of clinical pharmacology, therapy, and toxicology, 1992, Volume: 30, Issue:11 Topics: Biotransformation; Cyclosporine; Diltiazem; Erythromycin; Humans; Immunosuppressive Agents; In Vitro Techniques; Microsomes, Liver; Tacrolimus	1992
Amelioration of experimental cyclosporine nephrotoxicity by calcium channel inhibition. Transplantation, 1992, Volume: 54, Issue:6 Topics: Animals; Calcium Channel Blockers; Cyclosporine; Diltiazem; Glomerular Filtration Rate; Kidney; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Renal Circulation; Thromboxane B2	1992
Effect of age and gender on the activity of human hepatic CYP3A. Biochemical pharmacology, 1992, Jul-22, Volume: 44, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Aging; Alcohol Drinking; Aryl Hydrocarbon Hydroxylases; Body Weight; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diltiazem; Humans; Lidocaine; Microsomes, Liver; Middle Aged; Nifedipine; Oxidoreductases, N-Demethylating; Quinidine; Sex Factors; Smoking	1992
Dose-dependent effect of cyclosporin on renal arterial resistance in dogs. The American journal of physiology, 1991, Volume: 261, Issue:6 Pt 2 Topics: Animals; Blood; Cyclosporine; Diltiazem; Dogs; Dose-Response Relationship, Drug; Endothelins; Kidney; Nitric Oxide; Nitroglycerin; Phentolamine; Receptors, Adrenergic, alpha; Renal Artery; Renal Veins; Sympathectomy; Vascular Resistance	1991
Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases. Cell biology international reports, 1991, Volume: 15, Issue:12 Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Kidney Diseases; Kidney Tubules; Leucine; Microscopy, Fluorescence; Nifedipine; Rabbits; Time Factors; Verapamil	1991
Selective activation of the sodium-independent, cyclosporin A-sensitive calcium pore of cardiac mitochondria by doxorubicin. Toxicology and applied pharmacology, 1993, Volume: 121, Issue:1 Topics: Animals; Calcium; Calcium Channels; Cell Fractionation; Cyclosporine; Diltiazem; Doxorubicin; In Vitro Techniques; Male; Membrane Potentials; Mitochondria, Heart; Rats; Rats, Sprague-Dawley; Ruthenium Red; Sodium	1993
The sodium-calcium antiport of heart mitochondria is not electroneutral. The Journal of biological chemistry, 1995, Jan-13, Volume: 270, Issue:2 Topics: Animals; Antiporters; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cattle; Cyclosporine; Diltiazem; Fluorescent Dyes; Hydrogen-Ion Concentration; Membrane Potentials; Mitochondria, Heart; Nigericin; Onium Compounds; Organophosphorus Compounds; Oxygen; Sodium; Sodium-Calcium Exchanger; Thermodynamics; Valinomycin	1995
Effect of calcium-channel blockers on cyclosporine clearance and use in renal transplant patients. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:11 Topics: Administration, Oral; Adult; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Graft Survival; Humans; Immunosuppression Therapy; Infusions, Intravenous; Kidney; Kidney Transplantation; Male; Middle Aged; Nifedipine; Nova Scotia; Retrospective Studies; Time Factors; Verapamil	1994
Selective downregulation of rat cardiac beta 1-adrenoceptors by cyclosporine A: prevention by diltiazem or angiotensin-converting enzyme inhibitors. Journal of the American College of Cardiology, 1995, Mar-01, Volume: 25, Issue:3 Topics: Animals; Cyclosporine; Diltiazem; Down-Regulation; Enalapril; Heart; Male; Myocardium; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1	1995
No effect of clodronate on cyclosporin A blood levels in heart transplant patients simultaneously treated with diltiazem and azathioprine. Therapeutic drug monitoring, 1994, Volume: 16, Issue:4 Topics: Adult; Aged; Azathioprine; Clodronic Acid; Cyclosporine; Diltiazem; Drug Interactions; Female; Heart Transplantation; Humans; Male; Middle Aged	1994
Cumulative side effects of cyclosporine and Ca antagonists: hypergalactinemia, mastadenoma, and gynecomastia. Transplantation proceedings, 1994, Volume: 26, Issue:6 Topics: Adenoma; Adult; Aged; Breast Neoplasms, Male; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Synergism; Female; Galactorrhea; Gynecomastia; Humans; Kidney Transplantation; Male; Middle Aged; Nifedipine; Nitrendipine	1994
Nontherapeutic cyclosporine levels. Sustained-release diltiazem products are not the same. Transplantation, 1994, Jun-15, Volume: 57, Issue:11 Topics: Cyclosporine; Delayed-Action Preparations; Diltiazem; Drug Interactions; Humans	1994
[Basic studies on the prevention of cyclosporin A induced nephrotoxicity]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1994, Volume: 85, Issue:5 Topics: Animals; Cyclosporine; Diltiazem; Humans; Kidney; Kidney Diseases; Lymphocyte Activation; Male; Rats; Rats, Wistar; Theophylline	1994
Preventive effects of diltiazem on cyclosporin A-induced vascular smooth muscle dysfunction. Transplant international : official journal of the European Society for Organ Transplantation, 1994, Volume: 7, Issue:3 Topics: Animals; Blood Pressure; Constriction, Pathologic; Cyclosporine; Diltiazem; Isometric Contraction; Male; Muscle, Smooth, Vascular; Random Allocation; Rats; Rats, Wistar; Vasoconstrictor Agents	1994
Vasculopathy in cyclosporine-treated renal allografts: possible protection by diltiazem. Clinical transplantation, 1994, Volume: 8, Issue:3 Pt 1 Topics: Adult; Arterioles; Azathioprine; Cyclosporine; Diltiazem; Female; Humans; Image Processing, Computer-Assisted; Kidney; Kidney Transplantation; Male; Prednisolone; Vascular Diseases	1994
Pharmacokinetics of cyclosporine in renal transplant patients on diltiazem. Transplantation proceedings, 1994, Volume: 26, Issue:4 Topics: Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Humans; Kidney Transplantation	1994
Calcium entry blockade may prevent cyclosporin A-induced hypersensitivity to angiotensin II and endothelial dysfunction in the rat aorta. European heart journal, 1993, Volume: 14 Suppl I Topics: Angiotensin II; Animals; Aorta; Cyclosporine; Diltiazem; Endothelium, Vascular; Male; Muscle Contraction; Muscle, Smooth, Vascular; Random Allocation; Rats; Rats, Wistar; Vasodilation	1993
Immunosuppressive properties of the benzothiazepine calcium antagonists diltiazem and clentiazem, with and without cyclosporine, in heterotopic rat heart transplantation. Transplantation, 1993, Volume: 56, Issue:1 Topics: Animals; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Rats; Rats, Inbred Lew; Rats, Inbred WF; Time Factors; Transplantation, Heterotopic; Transplantation, Homologous; Transplantation, Isogeneic	1993
Blockade of cyclosporine-induced vasoconstriction by the calcium channel blocker diltiazem in dogs. The Journal of thoracic and cardiovascular surgery, 1993, Volume: 106, Issue:3 Topics: Animals; Cyclosporine; Diltiazem; Dogs; Endothelins; Hindlimb; Nitroprusside; Renal Artery; Renal Circulation; Vasoconstriction	1993
Gingival hyperplasia in renal allograft recipients receiving cyclosporin-A and calcium antagonists. Journal of clinical periodontology, 1993, Volume: 20, Issue:4 Topics: Adult; Cross-Sectional Studies; Cyclosporine; Dental Calculus; Dental Plaque Index; Diltiazem; Drug Interactions; Female; Gingival Hyperplasia; Humans; Hypertension; Kidney Transplantation; Male; Middle Aged; Models, Dental; Nifedipine; Periodontal Index; Saliva	1993
Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem? Transplantation proceedings, 1996, Volume: 28, Issue:4 Topics: Adolescent; Adult; Aged; Calcium Channel Blockers; Cyclosporine; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Diltiazem; Duodenum; Female; Humans; Immunosuppressive Agents; Intestinal Mucosa; Kidney Transplantation; Male; Metabolic Clearance Rate; Microsomes; Middle Aged; Mixed Function Oxygenases; Sex Characteristics	1996
Evaluation of the frequency of HLA determinants in patients with gingival overgrowth induced by cyclosporine-A. Journal of clinical periodontology, 1996, Volume: 23, Issue:8 Topics: Adult; Antigenic Variation; Calcium Channel Blockers; Chi-Square Distribution; Cyclosporine; Diltiazem; Disease Susceptibility; Drug Combinations; Female; Gingival Overgrowth; HLA Antigens; HLA-DR1 Antigen; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Nifedipine; Pharmacogenetics; Statistics, Nonparametric; Verapamil	1996
Diltiazem does not always increase blood cyclosporin concentration. British journal of clinical pharmacology, 1996, Volume: 42, Issue:5 Topics: Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Humans; Immunosuppressive Agents; Middle Aged	1996
Survey of cyclosporin-sparing agent use in Australasian transplant centres. Australian and New Zealand journal of medicine, 1996, Volume: 26, Issue:6 Topics: Australia; Cyclosporine; Diltiazem; Drug Therapy, Combination; Humans; Immunosuppressive Agents; Ketoconazole; New Zealand; Organ Transplantation; Surveys and Questionnaires	1996
Cyclosporine A-induced contractions and prostacyclin release are maintained by extracellular calcium in rat aortic rings: role of protein kinase C. Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 56, Issue:2 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Calcium Channel Blockers; Cell Membrane; Cyclosporine; Cytosol; Diltiazem; Enzyme Inhibitors; Epoprostenol; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Staurosporine; Thapsigargin	1997
On the mechanism of rebounding of calcium in liver mitochondria. Biological chemistry, 1997, Volume: 378, Issue:10 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Binding Proteins; Cyclosporine; Diltiazem; Intracellular Membranes; Malonates; Membrane Potentials; Mitochondria, Liver; Permeability; Rats; Ruthenium Red; Sodium-Calcium Exchanger	1997
Diltiazem-cyclosporin pharmacokinetic interaction--dose-response relationship. British journal of clinical pharmacology, 1997, Volume: 44, Issue:5 Topics: Adult; Area Under Curve; Calcium Channel Blockers; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged	1997
The modulatory effect of diltiazem on human in vitro alloreactivity when used alone or in combination with cyclosporin A and/or methylprednisolone. Transplant international : official journal of the European Society for Organ Transplantation, 1997, Volume: 10, Issue:6 Topics: Adjuvants, Immunologic; Anti-Inflammatory Agents; Calcium Channel Blockers; Cell Survival; Cells, Cultured; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Graft Rejection; Humans; Immunosuppressive Agents; Lymphocytes; Methylprednisolone	1997
Lower incidence of liver graft rejection in patients on diltiazem plus cyclosporine therapy. Transplantation proceedings, 1998, Volume: 30, Issue:4 Topics: Acute Disease; Adolescent; Adult; Aged; Calcium Channel Blockers; Child; Cyclosporine; Diltiazem; Drug Therapy, Combination; Female; Graft Rejection; Humans; Immunosuppressive Agents; Incidence; Liver Transplantation; Male; Middle Aged; Muromonab-CD3; Retrospective Studies	1998
Diltiazem disposition and metabolism in recipients of renal transplants. Therapeutic drug monitoring, 1998, Volume: 20, Issue:4 Topics: Calcium Channel Blockers; Chemistry, Pharmaceutical; Cyclosporine; Delayed-Action Preparations; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Kidney Transplantation; Tissue Distribution	1998
Effect of metabolic inhibitors on cyclosporine pharmacokinetics using a population approach. Therapeutic drug monitoring, 1998, Volume: 20, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aged; Antifungal Agents; Calcium Channel Blockers; Child; Cyclosporine; Diltiazem; Drug Administration Schedule; Drug Interactions; Fluconazole; Heart-Lung Transplantation; Humans; Immunosuppressive Agents; Individuality; Itraconazole; Ketoconazole; Linear Models; Middle Aged	1998
First-pass metabolism of cyclosporine A in human intestine: inhibition by diltiazem. Transplantation proceedings, 1998, Volume: 30, Issue:6 Topics: Administration, Oral; Biotransformation; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Half-Life; Heart Transplantation; Humans; Immunosuppressive Agents; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestines; Liver; Male; Middle Aged; Patient Selection; Tissue Distribution	1998
Is there a beneficial effect of the calcium channel blocker diltiazem on cyclosporine A nephrotoxicity in rats? Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 1998, Volume: 50, Issue:4-6 Topics: Animals; Body Weight; Calcium Channel Blockers; Cyclosporine; Cytochrome P-450 Enzyme System; Diltiazem; Drug Interactions; Ethylmorphine; Female; Glomerular Filtration Rate; Glutathione; Immunosuppressive Agents; Kidney; Kidney Diseases; Liver; Organ Size; p-Aminohippuric Acid; Rats; Rats, Wistar	1998
Diltiazem modulates cyclosporin A induced renal hemodynamic effects but not its effect on plasma endothelin-1. Clinical transplantation, 1998, Volume: 12, Issue:5 Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cyclosporine; Diltiazem; Endothelin-1; Female; Glomerular Filtration Rate; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Renal Circulation; Vasoconstriction	1998
[The vasoconstrictor effect of cyclosporine on the pulmonary vein is mediated by its vehicle: the cremophor]. Annales de chirurgie, 1998, Volume: 52, Issue:8 Topics: Animals; Bicyclic Monoterpenes; Calcium Channel Blockers; Calcium Channels; Cyclooxygenase Inhibitors; Cyclosporine; Diltiazem; Dogs; Immunosuppressive Agents; Indomethacin; Isometric Contraction; Muscle, Smooth, Vascular; Pharmaceutical Vehicles; Polyethylene Glycols; Pulmonary Veins; Thromboxane A2; Vasoconstriction; Vasodilator Agents	1998
Absence of a dose-response of cyclosporine levels to clinically used doses of diltiazem and verapamil. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1999, Volume: 33, Issue:2 Topics: Administration, Oral; Calcium Channel Blockers; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Humans; Immunosuppressive Agents; Isradipine; Medical Records; Nifedipine; Radioimmunoassay; Retrospective Studies; Verapamil	1999
Immunomodulating effects of second-generation calcium channel blockers on experimental heart transplantation. European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes, 1999, Volume: 31, Issue:3 Topics: Adjuvants, Immunologic; Amlodipine; Animals; Benzimidazoles; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Therapy, Combination; Felodipine; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Mibefradil; Rats; Rats, Inbred Lew; Tetrahydronaphthalenes; Time Factors	1999
Cyclosporine-induced encephalopathy predisposed by diltiazem in a patient with aplastic anemia. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:6 Topics: Aged; Anemia, Aplastic; Brain Diseases; Calcium Channel Blockers; Cyclosporine; Diltiazem; Female; Humans; Immunosuppressive Agents; Thrombocytopenia	1999
Pharmacokinetic interactions between microemulsion formulated cyclosporine A and diltiazem in renal transplant recipients. European journal of clinical pharmacology, 1999, Volume: 55, Issue:5 Topics: Adult; Aged; Antihypertensive Agents; Cyclosporine; Diltiazem; Drug Interactions; Emulsions; Enzyme Inhibitors; Female; Humans; Kidney; Kidney Transplantation; Male; Middle Aged	1999
Cyclosporine A-induced prostacyclin release is maintained by extracellular calcium in rat aortic endothelial cells: role of protein kinase C. Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 61, Issue:2 Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Cyclosporine; Diltiazem; Endothelium, Vascular; Epoprostenol; Male; Protein Kinase C; Rats; Thapsigargin	1999
The Canadian Study of Cardiac Transplantation. Atherosclerosis. Investigators of the CASCADE Study. The Canadian journal of cardiology, 1999, Volume: 15, Issue:12 Topics: Adult; Antihypertensive Agents; Arteriosclerosis; Aspirin; Cardiovascular Agents; Cyclosporine; Cytomegalovirus Infections; Diltiazem; Female; Follow-Up Studies; Heart Transplantation; Humans; Male; Middle Aged; Myocardial Ischemia; Postoperative Care; Postoperative Complications	1999
Effects of combined oral treatments with cyclosporine A and nifedipine or diltiazem on drug-induced gingival overgrowth in rats. Journal of periodontology, 2000, Volume: 71, Issue:3 Topics: Administration, Oral; Analysis of Variance; Animals; Body Weight; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Combinations; Drug Interactions; Gingiva; Gingival Overgrowth; Growth; Immunosuppressive Agents; Male; Nifedipine; Rats; Rats, Inbred F344; Single-Blind Method	2000
Structure-activity relationship of P-glycoprotein substrates and modifiers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 12, Issue:1 Topics: Adenosine Triphosphatases; Amiodarone; Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Daunorubicin; Diltiazem; Kinetics; Micelles; Progesterone; Propranolol; Structure-Activity Relationship; Verapamil; Vinblastine	2000
Pharmacokinetics of cyclosporine in heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2001, Volume: 20, Issue:4 Topics: Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Interactions; Female; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Linear Models; Male; Middle Aged; Multivariate Analysis	2001
Effect of calcium channel antagonist diltiazem and calcium ionophore A23187 on cyclosporine A-induced apoptosis of renal tubular cells. FEBS letters, 2002, Apr-10, Volume: 516, Issue:1-3 Topics: Animals; Apoptosis; Calcimycin; Calcium; Calcium Channel Blockers; Caspase 3; Caspases; Cells, Cultured; Cyclosporine; Diltiazem; DNA Fragmentation; DNA-Binding Proteins; Dogs; Enzyme Activation; Gene Expression; Genes, bcl-2; Ionophores; Kidney Tubules; NFATC Transcription Factors; Nuclear Proteins; Transcription Factors	2002
Associations between use of cyclosporine-sparing agents and outcome in kidney transplant recipients. Kidney international, 2002, Volume: 61, Issue:6 Topics: Adjuvants, Immunologic; Cohort Studies; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Graft Rejection; Graft Survival; Humans; Immunosuppressive Agents; Incidence; Kidney; Kidney Transplantation; Proportional Hazards Models; Registries; Survival Analysis; Time Factors; Treatment Outcome	2002
Cyclosporin monitoring in Australasia: 2002 update of consensus guidelines. Therapeutic drug monitoring, 2002, Volume: 24, Issue:6 Topics: Area Under Curve; Asia; Australia; Cyclosporine; Diltiazem; Drug Interactions; Drug Monitoring; Drugs, Generic; Guidelines as Topic; Humans; Immunoassay; Indicator Dilution Techniques; Quality Control; Reproducibility of Results	2002
Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection. European journal of ophthalmology, 2003, Volume: 13 Suppl 3 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Caspase 3; Caspases; Cyclosporine; Cytochrome c Group; Cytoprotection; Diltiazem; Female; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Organometallic Compounds; Oxygen Consumption; Rats; Rats, Long-Evans; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Sodium-Calcium Exchanger; Verapamil	2003
Impact of diltiazem administration and cyclosporine levels on the incidence of acute rejection in heart transplant patients. Transplant international : official journal of the European Society for Organ Transplantation, 2003, Volume: 16, Issue:9 Topics: Acute Disease; Adolescent; Adult; Antihypertensive Agents; Cyclosporine; Diltiazem; Female; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Risk Factors; Time Factors	2003
Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2003, Volume: 22, Issue:7 Topics: Antifungal Agents; Area Under Curve; Biological Availability; Calcium Channel Blockers; Cyclosporine; Cyclosporins; Diltiazem; Dose-Response Relationship, Drug; Drug Monitoring; Enzyme Inhibitors; Female; Heart Transplantation; Humans; Ketoconazole; Male; Middle Aged; Predictive Value of Tests; Statistics as Topic; Time; Time Factors	2003
Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries. The Journal of physiology, 2004, May-01, Volume: 556, Issue:Pt 3 Topics: Animals; Bongkrekic Acid; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Calcium-Binding Proteins; Calcium-Transporting ATPases; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Arteries; Clonazepam; Cyclosporine; Diltiazem; Female; Hydrogen Peroxide; Indazoles; Ion Channels; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria, Muscle; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Smooth Muscle; Oligomycins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rhodamines; Rotenone; Ruthenium Compounds; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger; Thapsigargin; Thiazepines	2004
Kinetic analyses for species differences in P-glycoprotein-mediated drug transport. Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Cyclosporine; Dexamethasone; Diltiazem; Dogs; Haplorhini; Humans; Kinetics; LLC-PK1 Cells; Mice; Rats; Species Specificity; Swine; Transfection	2006
Effect of diltiazem on the pharmacokinetics of microemulsion cyclosporine A in renal transplantation. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006, Volume: 89 Suppl 2 Topics: Absorption; Adult; Area Under Curve; Cyclosporine; Diltiazem; Drug Administration Schedule; Drug Monitoring; Emulsions; Female; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Postoperative Period; Vasodilator Agents	2006
Co-administration of diltiazem and cyclosporine for kidney transplant recipients: a four year follow-up study. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2006, Volume: 89 Suppl 2 Topics: Absorption; Adult; Area Under Curve; Blood Pressure; Creatinine; Cyclosporine; Diltiazem; Drug Administration Schedule; Drug Therapy, Combination; Emulsions; Female; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Postoperative Period; Vasodilator Agents	2006
Decision support tool to individualize cyclosporine dose in stable, long-term heart transplant recipients receiving metabolic inhibitors: overcoming limitations of cyclosporine C2 monitoring. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2006, Volume: 25, Issue:10 Topics: Area Under Curve; Bayes Theorem; Cardiovascular Agents; Cyclosporine; Decision Support Techniques; Diltiazem; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Feedback, Physiological; Heart Transplantation; Humans; Immunosuppressive Agents; Ketoconazole; Predictive Value of Tests; Time Factors	2006
Comparative interaction of few antihypertensive drugs with cyclosporine-A in rats. Indian journal of experimental biology, 2007, Volume: 45, Issue:7 Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta, Thoracic; Chromatography, High Pressure Liquid; Cyclosporine; Diltiazem; Drug Interactions; Enalapril; Losartan; Male; Olive Oil; Plant Oils; Propranolol; Rats; Rats, Wistar	2007
[Prevention of diltiazem in tacrolimus-induced nephrotoxicity: experiment with rats]. Zhonghua yi xue za zhi, 2007, Aug-28, Volume: 87, Issue:32 Topics: Animals; Creatine; Cyclosporine; Diltiazem; Disease Models, Animal; Dose-Response Relationship, Drug; Kidney; Kidney Diseases; Kidney Transplantation; Male; Postoperative Period; Random Allocation; Rats; Rats, Sprague-Dawley; Tacrolimus	2007
Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem. European journal of clinical pharmacology, 2009, Volume: 65, Issue:3 Topics: Adult; Aged; Asian People; Calcium Channel Blockers; Cyclosporine; Cytochrome P-450 CYP3A; Diltiazem; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Genotype; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Polymorphism, Genetic; Time Factors; Young Adult	2009
Modulation of human peripheral blood mononuclear cell proliferative response by diltiazem : in vitro comparison in younger versus older subjects. Drugs & aging, 2009, Volume: 26, Issue:1 Topics: Adult; Age Factors; Aged; Aging; Antibodies, Monoclonal; Antihypertensive Agents; CD3 Complex; Cell Proliferation; Cyclosporine; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; Immunosuppressive Agents; Interleukin-2; Leukocytes, Mononuclear; Male; Middle Aged; Pokeweed Mitogens; Tuberculin; Young Adult	2009
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. Pediatric nephrology (Berlin, Germany), 2010, Volume: 25, Issue:7 Topics: Administration, Oral; Antiphospholipid Syndrome; Aspirin; Calcinosis; Child; Cyclosporine; Dermatologic Agents; Diltiazem; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Glomerulonephritis, Membranoproliferative; Glucocorticoids; Humans; Lupus Erythematosus, Systemic; Male; Skin Ulcer; Treatment Outcome	2010
Long-term follow-up of co-administration of diltiazem and cyclosporine in Chinese kidney transplant recipients. Renal failure, 2010, Volume: 32, Issue:3 Topics: Administration, Oral; Adult; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Therapy, Combination; Female; Graft Survival; Humans; Immunosuppressive Agents; Kidney Transplantation; Male; Survival Rate	2010
The potential role of bone scintigraphy in the detection of deep muscular fascia involvement and calcinosis cutis in anti-synthetase syndrome. International journal of rheumatic diseases, 2013, Volume: 16, Issue:4 Topics: Adult; Back Muscles; Calcinosis; Comorbidity; Cyclosporine; Diltiazem; Drug Therapy, Combination; Female; Humans; Myositis; Prednisolone; Radionuclide Imaging; Skin Diseases; Technetium; Treatment Outcome	2013
Diltiazem augments the influence of MDR1 genotype status on cyclosporine concentration in Chinese patients with renal transplantation. Acta pharmacologica Sinica, 2015, Volume: 36, Issue:7 Topics: Adolescent; Adult; Aged; Asian People; ATP Binding Cassette Transporter, Subfamily B; Calcineurin Inhibitors; Cyclosporine; Diltiazem; Drug Synergism; Drug Therapy, Combination; Female; Genotype; Humans; Kidney Transplantation; Male; Middle Aged; Polymorphism, Single Nucleotide; Young Adult	2015
Diltiazem aggravates testicular function impairment induced by cyclosporine A or tacrolimus in unilateral nephrectomised rats. Andrologia, 2019, Volume: 51, Issue:5 Topics: Animals; Calcineurin Inhibitors; Calcium Channel Blockers; Cyclosporine; Diltiazem; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Gonadal Steroid Hormones; Graft Rejection; Humans; Immunosuppressive Agents; Kidney; Kidney Transplantation; Male; Microscopy, Electron, Transmission; Nephrectomy; Rats; Rats, Sprague-Dawley; Semen Analysis; Sperm Motility; Tacrolimus; Testis	2019
Takayasu arteritis in a rural hospital in Indonesia. BMJ case reports, 2020, Jan-08, Volume: 13, Issue:1 Topics: Adolescent; Angiography; Antihypertensive Agents; Cyclosporine; Diagnosis, Differential; Diltiazem; Drug Therapy, Combination; Electrocardiography; Female; Fever; Glucocorticoids; Hospitals, Rural; Humans; Immunosuppressive Agents; Indonesia; Methylprednisolone; Takayasu Arteritis	2020
Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care. Journal of medical Internet research, 2020, 10-16, Volume: 22, Issue:10 Topics: Cohort Studies; Cyclosporine; Diltiazem; Electronic Health Records; England; Female; Humans; Inappropriate Prescribing; Male; Primary Health Care; Retrospective Studies; Tacrolimus	2020
Diltiazem as a cyclosporine A-sparing agent in heart transplantation: Benefits beyond dose reduction. Medicine, 2022, Oct-14, Volume: 101, Issue:41 Topics: Adult; Calcineurin Inhibitors; Cyclosporine; Diltiazem; Drug Tapering; Graft Rejection; Heart Transplantation; Humans; Immunosuppressive Agents; Mycophenolic Acid; Retrospective Studies	2022