diltiazem has been researched along with cocaine in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (16.13) | 18.7374 |
| 1990's | 6 (19.35) | 18.2507 |
| 2000's | 14 (45.16) | 29.6817 |
| 2010's | 6 (19.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Keserü, GM | 1 |
| Li, J; Rajamani, R; Reynolds, CH; Tounge, BA | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Hitner, HW; Mahalik, MP | 1 |
| Masukawa, Y; Misawa, M; Shiozaki, Y; Suzuki, T | 1 |
| Rogério, R; Takahashi, RN | 1 |
| Chiba, S; Ohkubo, H | 1 |
| Albertson, TE; Derlet, RW | 1 |
| Hooker, WD; Jones, RT; Mendelson, J; Rowbotham, MC | 1 |
| Galzin, AM; Langer, SZ | 1 |
| Goldberg, SR; Prada, J; Schindler, CW; Tella, SR | 1 |
| Arnaoudov, PI; Latour, C; Nahas, GG; Trouvé, R | 1 |
| Bedingfield, JB; Calder, LD; Karler, R | 1 |
| Baker, DA; Kalivas, PW; Shen, H | 1 |
| Carlezon, WA; Chartoff, EH; Pliakas, AM | 1 |
| Ali, SF; Ansah, TA; Mills, K; Mukherjee, S; Shockley, DC | 1 |
| Anderson, SM; Bass, CE; Cha, JH; Famous, KR; Kumaresan, V; Pierce, RC; Sadri-Vakili, G; Schmidt, HD; Terwilliger, EF | 1 |
| Aragon, CM; Baliño, P; Pastor, R | 1 |
| Cadet-Taïrou, A; Evrard, I; Legleye, S | 1 |
| Daldrup, T; Hartung, B; Mahler, H; Pawlik, E; Plässer, G | 1 |
| Daldrup, T; Knuth, M; Pawlik, E; Temme, O | 1 |
1 trial(s) available for diltiazem and cocaine
| Article | Year |
|---|---|
Cocaine-calcium channel antagonist interactions.
Topics: Adult; Affect; Blood Pressure; Cocaine; Diltiazem; Double-Blind Method; Heart Rate; Humans; Male; Pupil; Skin Temperature | 1987 |
30 other study(ies) available for diltiazem and cocaine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
A two-state homology model of the hERG K+ channel: application to ligand binding.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation | 2005 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Antagonism of cocaine-induced fetal anomalies by prazosin and diltiazem in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cocaine; Diltiazem; Dose-Response Relationship, Drug; Female; Fetal Resorption; Male; Mice; Organ Size; Prazosin; Pregnancy; Teratogens; Vasoconstriction | 1992 |
Effects of calcium antagonists on the cocaine- and methamphetamine-induced conditioned place preference.
Topics: Animals; Calcium Channel Blockers; Cocaine; Conditioning, Psychological; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Methamphetamine; Nifedipine; Rats; Rats, Inbred Strains | 1992 |
Some calcium channel antagonists have no effect on the open-field behavior of rats nor do they interact with cocaine.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cocaine; Diltiazem; Drug Interactions; Male; Motor Activity; Nifedipine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Vascular responses of ophthalmic arteries to exogenous and endogenous norepinephrine.
Topics: Animals; Calcium; Cocaine; Diltiazem; Dogs; Egtazic Acid; Electric Stimulation; Hydrocortisone; Imipramine; In Vitro Techniques; Norepinephrine; Ophthalmic Artery; Perfusion; Potassium Chloride; Tyramine; Vasoconstriction | 1989 |
Potentiation of cocaine toxicity with calcium channel blockers.
Topics: Animals; Cocaine; Diltiazem; Drug Synergism; Injections, Intraperitoneal; Male; Nifedipine; Rats; Rats, Inbred Strains; Seizures; Verapamil | 1989 |
Presynaptic alpha 2-adrenoceptor antagonism by verapamil but not by diltiazem in rabbit hypothalamic slices.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Calcium Channel Blockers; Clonidine; Cocaine; Diltiazem; Epinephrine; Hypothalamus; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Verapamil | 1983 |
Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cocaine; Conditioning, Psychological; Diltiazem; Heart Rate; Male; Nimodipine; Saimiri; Self Administration; Verapamil | 1995 |
Effects of antidotes to cocaine on the deregulation of the baroreflex by the alkaloid.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Antidotes; Baroreflex; Blood Pressure; Cocaine; Diltiazem; Enalaprilat; Nicardipine; Rats; Rats, Sprague-Dawley | 1996 |
Comparative behavioral sensitization to stereotypy by direct and indirect dopamine agonists in CF-1 mice.
Topics: Amphetamine; Animals; Apomorphine; Cocaine; Diltiazem; Dopamine Agonists; Drug Interactions; Fluoresceins; Male; Mice; Quinoxalines; Stereotyped Behavior | 1996 |
Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Cocaine; Cystine; Diltiazem; Dopamine Uptake Inhibitors; Glutamic Acid; Microdialysis; Nucleus Accumbens; omega-Conotoxins; Rats; Tetrodotoxin | 2002 |
Microinjection of the L-type calcium channel antagonist diltiazem into the ventral nucleus accumbens shell facilitates cocaine-induced conditioned place preferences.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Choice Behavior; Cocaine; Conditioning, Operant; Diltiazem; Dose-Response Relationship, Drug; Male; Microinjections; Nucleus Accumbens; Rats; Rats, Sprague-Dawley | 2006 |
Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Biological Transport, Active; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Radioisotopes; Caudate Nucleus; Cocaine; Diltiazem; Flunarizine; Male; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Synaptosomes | 2007 |
CaMKII: a biochemical bridge linking accumbens dopamine and glutamate systems in cocaine seeking.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cocaine; Cocaine-Related Disorders; Diltiazem; Dopamine; Dopamine Agonists; Dopamine Uptake Inhibitors; Glutamic Acid; Male; Nucleus Accumbens; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Synaptic Transmission; Threonine | 2008 |
Participation of L-type calcium channels in ethanol-induced behavioral stimulation and motor incoordination: effects of diltiazem and verapamil.
Topics: Analysis of Variance; Animals; Ataxia; Behavior, Animal; Caffeine; Calcium Channel Blockers; Calcium Channels, L-Type; Central Nervous System Stimulants; Cocaine; Diltiazem; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Motor Activity; Rotarod Performance Test; Verapamil | 2010 |
Composition, purity and perceived quality of street cocaine in France.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Data Collection; Diltiazem; Drug Contamination; Drug Users; Female; France; Humans; Illicit Drugs; Lidocaine; Male; Middle Aged; Smoking; Young Adult | 2010 |
Drug-related death: adulterants from cocaine preparations in lung tissue and blood.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Cocaine; Cocaine-Related Disorders; Diltiazem; Drug Contamination; Forensic Toxicology; Humans; Hydroxyzine; Illicit Drugs; Levamisole; Lidocaine; Liquid-Liquid Extraction; Lung; Mass Spectrometry; Narcotics; Phenacetin; Solid Phase Extraction | 2015 |
Analysis of cocaine adulterants in human brain in cases of drug-related death.
Topics: Brain Chemistry; Cetirizine; Cocaine; Cocaine-Related Disorders; Diltiazem; Drug Contamination; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyzine; Levamisole; Lidocaine; Narcotics; Phenacetin; Reproducibility of Results; Solid Phase Extraction | 2018 |