diltiazem has been researched along with clonidine in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (24.44) | 18.7374 |
| 1990's | 13 (28.89) | 18.2507 |
| 2000's | 16 (35.56) | 29.6817 |
| 2010's | 5 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Blayney, LM; Gapper, PW; Newby, AC | 1 |
| Chiba, S; Skrbic, R | 1 |
| Mustafa, AA | 1 |
| Butler, BT; Kusiak, JW; Piascik, MT; Pruitt, TA | 1 |
| Alfaro, MJ; Colado, MI; López, F; Martín, MI | 1 |
| Cerný, J; Dostál, M; Gregor, Z; Guba, P; Rebícek, J; Sotolová, O; Urbánek, P; Vasků, A; Vasků, J | 1 |
| Chiba, S; Ito, T | 1 |
| Cusolito, S; Donowitz, M; el Sabban, ME; Homaidan, FR; Sharp, WG; Weiland, GA; Wicks, J | 1 |
| Bou, J; Massingham, R | 1 |
| Auclair, MC; Schmitt, H | 1 |
| Toda, N | 1 |
| Starke, K; Wichmann, T; Zelis, R | 1 |
| Galzin, AM; Langer, SZ | 1 |
| Izumi, F; Kobayashi, H; Sakurai, S; Wada, A; Yanagihara, N | 1 |
| Jarrott, B; Nayler, WG; Thompson, JE | 1 |
| Brandt, D | 1 |
| Baeyens, JM; Barrios, M; Robles, I | 1 |
| Hellman, B; Saha, S | 1 |
| Alfaro, MJ; Colado, MI; Del Val, V; Lopez, F; Martin, MI | 1 |
| Cushman, WC; Freis, ED; Fye, C; Gottdiener, J; Hamburger, RJ; Kochar, MS; Lakshman, R; Massie, BM; Materson, BJ; Reda, DJ | 1 |
| Carrón, R; Montero, MJ; Morán, A; Prieto, P; Román, LS | 1 |
| Bakris, GL; Smith, A | 1 |
| Anderson, RJ; Gottdiener, JS; Massie, BM; Materson, BJ; Reda, DJ; Williams, DW | 1 |
| Cushman, WC; Freis, ED; Lakshman, MR; Materson, BJ; Reda, DJ | 1 |
| Kishioka, S; Ko, MC; Woods, JH | 1 |
| Nath, C; Srivastava, SK | 1 |
| Cushman, WC; Materson, BJ; Reda, DJ; Williams, DW | 1 |
| David, RB; De Luca, LA; Menani, JV; Pereira, DT; Sugawara, AM | 1 |
| Akritidis, N; Katsanou, A; Koutsouka, F; Pappas, G; Petrakis, D; Raptis, L | 1 |
1 review(s) available for diltiazem and clonidine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
5 trial(s) available for diltiazem and clonidine
| Article | Year |
|---|---|
Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Age Factors; Aged; Antihypertensive Agents; Atenolol; Black People; Blood Pressure; Captopril; Clonidine; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin | 1993 |
Effects of sodium intake on albumin excretion in patients with diabetic nephropathy treated with long-acting calcium antagonists.
Topics: Aged; Albuminuria; Antihypertensive Agents; Calcium Channel Blockers; Clonidine; Cross-Over Studies; Diabetic Nephropathies; Diltiazem; Female; Humans; Male; Middle Aged; Nifedipine; Prospective Studies; Sodium, Dietary | 1996 |
Effect of single-drug therapy on reduction of left ventricular mass in mild to moderate hypertension: comparison of six antihypertensive agents. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Captopril; Clonidine; Cohort Studies; Diltiazem; Diuretics; Double-Blind Method; Echocardiography; Follow-Up Studies; Humans; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Myocardium; Organ Size; Prazosin; Prevalence; Risk Factors; Sodium Chloride Symporter Inhibitors; Treatment Outcome; United States; United States Department of Veterans Affairs | 1997 |
Diuretics and beta-blockers do not have adverse effects at 1 year on plasma lipid and lipoprotein profiles in men with hypertension. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Blood Glucose; Captopril; Clonidine; Diltiazem; Diuretics; Double-Blind Method; Hospitals, Veterans; Humans; Hydrochlorothiazide; Hypertension; Lipids; Lipoproteins; Male; Middle Aged; Potassium; Prazosin; Time Factors; Treatment Outcome; United States | 1999 |
Pulse pressure changes with six classes of antihypertensive agents in a randomized, controlled trial.
Topics: Adult; Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Captopril; Clonidine; Diastole; Diltiazem; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Prazosin; Pressure; Pulse; Randomized Controlled Trials as Topic; Systole; Time Factors; Treatment Outcome | 2001 |
39 other study(ies) available for diltiazem and clonidine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.
Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Vasoconstrictor agonists activate G-protein-dependent receptor-operated calcium channels in pig aortic microsomes.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Aorta; Calcium; Calcium Channels; Cell Membrane; Clonidine; Diltiazem; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Imidazoles; Microsomes; Muscle, Smooth, Vascular; Norepinephrine; Receptors, Adrenergic, alpha; Swine; Vasoconstrictor Agents | 1992 |
Pharmacological properties of alpha 1-adrenoceptor-mediated vasoconstrictions in dog and monkey lingual arteries: evidence for subtypes of alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channels; Clonidine; Diltiazem; Dioxanes; Dogs; Dose-Response Relationship, Drug; Macaca; Muscle, Smooth, Vascular; Norepinephrine; Receptors, Adrenergic; Signal Transduction; Species Specificity; Tongue; Vasoconstriction | 1992 |
Rapid desensitization of central beta-adrenoceptors in rat after subacute treatment with imipramine and calcium entry blockers.
Topics: 1-Propanol; Animals; Calcium Channel Blockers; Clonidine; Diltiazem; DOM 2,5-Dimethoxy-4-Methylamphetamine; Drinking Behavior; Fenclonine; Imipramine; Isoproterenol; Ketanserin; Nicardipine; Nifedipine; Oxidopamine; Rats; Receptors, Adrenergic, beta; Verapamil | 1991 |
Agonist interaction with alkylation-sensitive and -resistant alpha-1 adrenoceptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Clonidine; Diltiazem; Dioxanes; Drug Interactions; Heart; Inositol Phosphates; Male; Muscle, Smooth, Vascular; Myocardium; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
Effect of clonidine, nimodipine and diltiazem on the in vitro opioid withdrawal response in the guinea-pig ileum.
Topics: Animals; Clonidine; Diltiazem; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Nimodipine; Substance Withdrawal Syndrome | 1990 |
[Therapy of venous hypertension in animals with an artificial heart and long-term survival].
Topics: Animals; Antihypertensive Agents; Captopril; Cattle; Clonidine; Diltiazem; Heart, Artificial; Methyldopa; Nifedipine; Prazosin; Venous Pressure | 1989 |
Effects of calcium antagonists on alpha-adrenoceptor mediated vasoconstrictions of the canine intermediate auricular artery.
Topics: Animals; Arteries; Clonidine; Diltiazem; Dogs; Female; In Vitro Techniques; Male; Norepinephrine; Phenylephrine; Potassium Chloride; Receptors, Adrenergic, alpha; Skin; Vasoconstriction; Verapamil | 1987 |
Ca2+ channel blockers interact with alpha 2-adrenergic receptors in rabbit ileum.
Topics: Animals; Calcium Channel Blockers; Clonidine; Diltiazem; Egtazic Acid; Electrolytes; Ileum; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Membrane Potentials; Nifedipine; Rabbits; Receptors, Adrenergic, alpha; Verapamil; Yohimbine | 1988 |
Effect of diltiazem upon contractile responses to phenylephrine, cirazoline, Sgd 101/75, St 587 and B-HT 920 in rabbit aorta and dog saphenous vein preparations.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Azepines; Benzazepines; Clonidine; Diltiazem; Dogs; Drug Interactions; Female; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rabbits; Saphenous Vein | 1986 |
Antagonism by E. coli endotoxin of some cardiovascular effects induced in the rat by two alpha 2-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Diltiazem; Endotoxins; Escherichia coli; Heart Rate; Male; Rats; Rats, Inbred Strains | 1987 |
Responsiveness of isolated monkey coronary arteries contracted with alpha 1- and alpha 2-adrenoceptor agonists to diltiazem.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Coronary Vessels; Diltiazem; Dinoprost; Female; In Vitro Techniques; Macaca; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Prostaglandins F; Receptors, Prostaglandin | 1988 |
Inhibition by diltiazem of norepinephrine release from sympathetic nerves in the rabbit pulmonary artery.
Topics: Animals; Benzazepines; Clonidine; Depression, Chemical; Diltiazem; Drug Interactions; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Neurons; Norepinephrine; Potassium Chloride; Pulmonary Artery; Rabbits; Sympathetic Nervous System; Time Factors | 1985 |
Presynaptic alpha 2-adrenoceptor antagonism by verapamil but not by diltiazem in rabbit hypothalamic slices.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Calcium Channel Blockers; Clonidine; Cocaine; Diltiazem; Epinephrine; Hypothalamus; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Verapamil | 1983 |
Inhibition by alpha 2-adrenoceptor agonists of the secretion of catecholamines from isolated adrenal medullary cells.
Topics: Adrenal Medulla; Adrenergic alpha-Agonists; Animals; Calcium; Catecholamines; Cattle; Clonidine; Diltiazem; In Vitro Techniques; Tubocurarine; Yohimbine | 1983 |
The interaction of calcium antagonists (slow channel blockers) with myocardial alpha adrenoceptors.
Topics: Animals; Brain; Calcium Channel Blockers; Clonidine; Diltiazem; Gallopamil; In Vitro Techniques; Male; Myocardium; Nifedipine; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Verapamil | 1982 |
[The hypertensive crisis].
Topics: Acute Disease; Calcium Channel Blockers; Clonidine; Coronary Disease; Diazoxide; Dihydralazine; Diltiazem; Heart Failure; Humans; Hypertension; Nifedipine; Nitroprusside; Sympatholytics; Verapamil | 1984 |
Role of L-type calcium channels on yohimbine-precipitated clonidine withdrawal in vivo and in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Behavior, Animal; Calcium Channels; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Implants; Female; Ileum; In Vitro Techniques; Isomerism; Mice; Muscle Contraction; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Verapamil; Yohimbine | 1993 |
Alpha 2-adrenergic stimulation counteracts glucose-induced rise of sodium in pancreatic islets exposed to ouabain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bucladesine; Calcium Channel Blockers; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Gallopamil; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Mice; Mice, Obese; Sodium; Tolbutamide; Yohimbine | 1995 |
Effect of nimodipine, diltiazem and BAY K 8644 on the behavioural and neurochemical changes associated with naloxone-precipitated withdrawal in the rat. A comparison with clonidine.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Behavior, Animal; Brain Chemistry; Clonidine; Diltiazem; Hydroxyindoleacetic Acid; Male; Morphine Dependence; Naloxone; Nimodipine; Rats; Rats, Sprague-Dawley; Serotonin; Spinal Cord; Substance Withdrawal Syndrome | 1993 |
MR-14134, a new benzothiazepine with central hypotensive action.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Binding, Competitive; Blood Pressure; Clonidine; Decerebrate State; Diltiazem; Dose-Response Relationship, Drug; Heart Rate; Injections, Intraventricular; Male; Rats; Rats, Wistar; Yohimbine | 1995 |
Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzimidazoles; Calcium Channel Blockers; Clonidine; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Female; Fentanyl; Heroin; Macaca mulatta; Male; Morphine; Nalbuphine; Pain Measurement; Receptors, Opioid; Respiration; Time Factors | 2000 |
The differential effects of calcium channel blockers in the behavioural despair test in mice.
Topics: Animals; Antidepressive Agents; Calcium Channel Blockers; Clomipramine; Clonidine; Cyproheptadine; Depression; Desipramine; Diltiazem; Drug Interactions; Female; Male; Mianserin; Mice; Motor Activity; Nifedipine; Tranylcypromine; Verapamil | 2000 |
Interaction between brain L-type calcium channels and alpha2-adrenoceptors in the inhibition of sodium appetite.
Topics: Adrenergic alpha-Agonists; Animals; Appetite; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Clonidine; Diltiazem; Feeding Behavior; Injections, Intraventricular; Male; Norepinephrine; Rats; Receptors, Adrenergic, alpha-2; Sodium; Sodium, Dietary | 2002 |
Diltiazem-induced eosinophilic pleural effusion.
Topics: Administration, Oral; Aged; Antihypertensive Agents; Clonidine; Diltiazem; Eosinophilia; Female; Humans; Hypertension; Pleural Effusion | 2007 |