diltiazem has been researched along with clentiazem in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (11.25) | 18.7374 |
| 1990's | 69 (86.25) | 18.2507 |
| 2000's | 1 (1.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (1.25) | 2.80 |
| Authors | Studies |
|---|---|
| Das, J; Duff, KJ; Floyd, DM; Kimball, SD; Krapcho, J; Lago, MW; Lee, VG; Moquin, RV; Turk, CF; White, RE | 1 |
| Das, J; Duff, KJ; Floyd, DM; Gougoutas, JZ; Kimball, SD; Lago, MW; Lee, VG; Malley, MF; Moquin, RV; Vu, TC | 1 |
| Fisher, M; Nunnari, JJ; White, SD | 1 |
| Kikkawa, K; Murata, S; Nagao, T | 2 |
| Banno, K; Iwasaki, H; Kikkawa, K; Murata, S; Nagao, T; Toriumi, W | 1 |
| Grupp, G; Grupp, I; Heikkila, J; Luomanmaki, K; Pesola, MK; Ramo, MP; Schroder, T | 1 |
| Baba, T; Chiyoda, K; Kikushima, S; Kobayashi, Y; Kurano, K; Miyata, A; Mukai, H; Nakagawa, H; Tanno, K; Yazawa, T | 1 |
| Cowley, AW; Lu, S; Mattson, DL; Roman, RJ | 1 |
| de Champlain, J; Garceau, D; Gaspo, R; Lamarche, L; Yamaguchi, N | 1 |
| Liang, D; Thurman, RG | 1 |
| Caillé, G; Cardinal, R; Croteau, D; Laflamme, AK; Lambert, C; Lamoureux, C | 1 |
| Ideka, M; Ito, Y; Koike, H; Miyake, S; Shiga, H; Yanagisawa, H | 1 |
| Fenoy, FJ; Mecca, TE; Milicic, I; Mistry, M; Roman, RJ | 1 |
| Kusano, S; Mori, M; Suzuki, S | 1 |
| Inoue, Y; Kitamura, K; Kuriyama, H; Sakai, T; Xiong, Z | 1 |
| Rampe, D; Triggle, DJ; Zheng, W | 1 |
| Dumont, L; Garceau, D; Garofalo, C; Levy, E; Seidman, E; Smith, L; Thibault, L | 1 |
| Frohlich, ED; Ketelhut, R; McLoughlin, M | 1 |
| Davies, NJ; Lopaschuk, GD; McVeigh, JJ | 1 |
| Bevan, JA; Bevan, RD; Vorkapic, P | 1 |
| Bendayan, M; Bouthillier, D; Garceau, D; Garofalo, C; Lavigne, F; Levy, E; Russo, P; St-Louis, J; Tardif, J; Thibault, L | 1 |
| Claude, C; Denis, G; Gilles, C; Louis, D; Marc, L; Valérie, V | 1 |
| Kwan-Yeung, L; Ng, D; Wong, K | 1 |
| Bleakman, D; Chard, PS; Foucart, S; Miller, RJ | 1 |
| Iqbal, A; Rubanyi, G; Schwartz, A; Vanhoutte, PM | 1 |
| Aoe, K; Date, T; Gaino, M; Hashiyama, T; Inoue, H; Konda, M; Murata, S; Otsuka, H; Takahashi, K; Takeda, M | 1 |
| Bevan, J; Kaminow, L | 1 |
| Hirota, Y; Ishikawa, H; Ishikawa, K; Kagoshima, T; Katori, R; Kawakita, S; Kinoshita, M | 1 |
| Archambeault, P; Caillé, G; Chartrand, C; Derouin, M; Dumont, L; Garceau, D | 1 |
| Kurosawa, H; Naito, K; Ohashi, M; Otsuka, M; Suzuki, T; Takaiti, O | 1 |
| Ginsburg, R; Narita, H | 1 |
| Ginsburg, R; Narita, H; Zera, PH | 1 |
| Fukuzaki, M; Haida, M; Kurita, D; Shinohara, Y; Taniguchi, R; Yamamoto, M; Yazaki, K | 1 |
| Brown, EM; Chen, CJ | 1 |
| Raij, L; Tolins, JP | 1 |
| Mecca, TE; Zobrist, RH | 1 |
| Caille, G; Garceau, D; Houle, JM; Lefebvre, M; Major, D; Spenard, J | 1 |
| Nakamura, S; Ohashi, M; Sugawara, Y; Suzuki, T; Takaiti, O; Usuki, S | 1 |
| Bevan, JA; Kaminow, L; Laher, I; Thompson, LP | 1 |
| Kitamura, K; Kuriyama, H; Nakao, K; Nishiye, E | 1 |
| Akimoto, Y; Kikkawa, K; Murata, S; Nagao, T; Narita, H; Sugawara, Y; Yabana, H | 1 |
| Frohlich, ED; Isshiki, T; Pegram, BL | 2 |
| Kikkawa, K; Murata, S; Nagao, T; Yabana, H | 1 |
| Nishi, H; Terabe, S | 1 |
| Iwasaki, H; Kikkawa, K; Kurosawa, H; Murata, S; Nagao, T; Toriumi, W | 1 |
| Dolphin, PJ; Graham, SE; Russell, JC; Stewart, B | 1 |
| Buluran, J; Cartier, R; Dagenais, F; Hollmann, C | 1 |
| Kinoshita, K; Matsuoka, Y; Yamamura, M | 1 |
| Latour, JG; Provost, P; Rousseau, G | 1 |
| Nakamura, S; Sugawara, Y | 1 |
| Blaise, G; Dumont, L; Garceau, D; Lepage, G; Tanguay, M | 1 |
| Bakris, G; Brown, S; Gaber, L; Walton, C | 1 |
| Karasawa, T; Katoh, M; Odawara, A; Sasaki, Y; Tamura, K | 1 |
| Gaino, M; Harada, T; Inoue, H; Matsuki, K; Nakamura, S; Otsuka, H; Takeda, M | 1 |
| Caillé, G; Latour, JG; Provost, P; Rousseau, G; Tran, D | 1 |
| Iwasaki, H; Morita, T; Saso, Y; Takashima, K; Yasoshima, A | 1 |
| Banno, K; Kikkawa, K; Murata, S; Nagao, T; Suzuki, T; Tetsuka, T; Yamauchi, R | 1 |
| Bhargava, VO; Giesing, DH; Nordbrock, EE; Shah, AK; Weir, SJ | 1 |
| Chen, H; Daloze, P; Dumont, L; Garceau, D; Xu, D | 1 |
| Iwasaki, H; Morita, T; Odawara, A; Ohtani, A; Saso, Y; Takashima, K | 1 |
| Barouki, F; el Fertak, L; Lévy, BI; Pieddeloup, C; Safar, ME | 1 |
| Bakris, GL; Brown, SA; Crawford, P; Walton, CL | 1 |
| Billingham, ME; Bristow, MR; Deisher, TA; Fowler, MB; Ginsburg, R; Hoffman, BB; Narita, H; Zera, P | 1 |
| Fukushima, T; Ito, Y; Nakamura, S; Ohashi, M; Sugawara, Y; Takaiti, O | 2 |
| Garceau, D; Waters, D | 1 |
| Bhargava, VO; Giesing, DH; Shah, AK; Weir, SJ | 1 |
| Sakaki, T; Sasaoka, Y; Shintomi, K; Tsujimoto, S; Tsunoda, S | 1 |
| Blaise, G; Dumont, L; Jasmin, G; Tanguay, M | 2 |
| Dumont, L; Garceau, D; Giasson, S; Homsy, W | 1 |
| Adaniya, H; Hiraoka, M; Miyazaki, K; Sawanobori, T | 1 |
| Alam, R; Alam, S; Kataoka, S; Yatsu, F | 1 |
| Alam, R; Dash, PK; Kataoka, S; Yatsu, FM | 1 |
| Corretti, MC; Koretsune, Y; Kusuoka, H; Marban, E | 1 |
| Chen, H; Daloze, P; Dumont, L; Lapointe, N; Qi, S; Xu, D | 1 |
| Fujisawa, R; Hanada, K; Kataoka, R; Nakamura, S; Ogata, H | 1 |
| Chen, F; Huang, Z; Li, Y; Liu, M; Sang, D; Yue, X | 1 |
1 review(s) available for diltiazem and clentiazem
| Article | Year |
|---|---|
Clentiazem and diltiazem preserve endothelium-dependent relaxation following global rat heart ischemia.
Topics: Animals; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium; Male; Myocardial Ischemia; Myocardial Reperfusion; Nitric Oxide; Rats; Rats, Sprague-Dawley | 1995 |
5 trial(s) available for diltiazem and clentiazem
| Article | Year |
|---|---|
Analysis of the daily variation in blood pressure and pharmacokinetics after single or repeated administration of clentiazem to patients with essential hypertension.
Topics: Aged; Blood Pressure; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Female; Heart; Humans; Hypertension; Male; Middle Aged; Pulse | 1992 |
Efficacy and safety of clentiazem in patients with essential hypertension: results of an early pilot test.
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Diltiazem; Drug Administration Schedule; Drug Evaluation; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Pilot Projects | 1991 |
Single and multiple oral dose pharmacokinetics of clentiazem in normal volunteers.
Topics: Administration, Oral; Adult; Diltiazem; Drug Administration Schedule; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged | 1993 |
A dose-response study of clentiazem, a chloro-derivative of diltiazem, in patients with stable angina. CAMCAT Study Group.
Topics: Aged; Angina Pectoris; Asthenia; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Double-Blind Method; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Treatment Outcome | 1993 |
Pharmacokinetics of clentiazem after intravenous and oral administration in healthy subjects.
Topics: Administration, Oral; Adult; Diltiazem; Humans; Injections, Intravenous; Male; Middle Aged | 1993 |
74 other study(ies) available for diltiazem and clentiazem
| Article | Year |
|---|---|
Benzazepinone calcium channel blockers. 2. Structure-activity and drug metabolism studies leading to potent antihypertensive agents. Comparison with benzothiazepinones.
Topics: Acetylation; Animals; Antihypertensive Agents; Aorta; Benzazepines; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Hypertension; Male; Microsomes, Liver; Molecular Conformation; Molecular Structure; Pyrrolidines; Rabbits; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Vasodilation | 1992 |
Benzazepinone calcium channel blockers. 3. Synthesis and structure-activity studies of 3-alkylbenzazepinones.
Topics: Animals; Antihypertensive Agents; Aorta; Benzazepines; Calcium Channel Blockers; Guinea Pigs; Hypertension; Male; Molecular Conformation; Molecular Structure; Muscles; Rabbits; Rats; Rats, Inbred SHR; Structure-Activity Relationship; Vasodilation; X-Ray Diffraction | 1992 |
Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Calcium Channel Blockers; Cell Adhesion; Cell Count; Cholesterol; Cholic Acids; Diet, Atherogenic; Diltiazem; Heart Rate; Hypercholesterolemia; Lipid Metabolism; Lipids; Male; Models, Biological; Monocytes; Rats; Rats, Wistar; Thiouracil | 1992 |
Cerebral vasodilating and spasmolytic actions of a new Ca-antagonist, clentiazem (TA-3090), in anesthetized animals.
Topics: Animals; Basilar Artery; Blood Pressure; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Diltiazem; Dinoprost; Dogs; Female; Infusions, Intravenous; Injections, Intravenous; Intracranial Pressure; Macaca fascicularis; Male; Papaverine; Parasympatholytics; Serotonin; Vasoconstriction; Vasodilator Agents | 1992 |
Prophylactic effects of a new 1,5-benzothiazepine calcium antagonist on stroke in salt-loaded stroke-prone spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Calcium Channel Blockers; Cerebral Cortex; Cerebrovascular Disorders; Circadian Rhythm; Diltiazem; Eating; Hypertension; Kidney Cortex; Male; Rats; Rats, Inbred SHR; Sodium Chloride | 1992 |
Cardiac glycosides in the treatment of experimental overdose with calcium-blocking agents.
Topics: Animals; Atropine; Calcium; Calcium Channel Blockers; Calcium Gluconate; Depression, Chemical; Digoxin; Diltiazem; Dogs; Drug Overdose; Electrocardiography; Female; Hemodynamics; Humans; Male; Myocardium; Verapamil | 1992 |
[Electrophysiologic effect of a new Ca(2+)-antagonist, TA-3090 on supraventricular tachycardia and conduction system].
Topics: Adult; Aged; Blood Pressure; Calcium Channel Blockers; Depression, Chemical; Diltiazem; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Humans; Male; Middle Aged; Tachycardia, Atrioventricular Nodal Reentry; Tachycardia, Supraventricular | 1992 |
Renal medullary interstitial infusion of diltiazem alters sodium and water excretion in rats.
Topics: Animals; Diltiazem; Diuresis; Dose-Response Relationship, Drug; Extracellular Space; Glomerular Filtration Rate; Hemodynamics; Injections; Injections, Intravenous; Kidney; Kidney Medulla; Male; Natriuresis; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Renal Circulation | 1992 |
Effects of clentiazem (TA-3090) and nifedipine on basal circulating catecholamine levels and on stimulation-evoked adrenal catecholamine secretion in anesthetized dogs.
Topics: Adrenal Glands; Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Catecholamines; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Male; Nifedipine; Pressoreceptors; Reflex; Regional Blood Flow; Splanchnic Nerves | 1992 |
Protective effects of the calcium antagonists diltiazem and TA3090 against hepatic injury due to hypoxia.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Female; Hypoxia; Ischemia; L-Lactate Dehydrogenase; Liver; Liver Diseases; Oxygen; Rats; Rats, Sprague-Dawley; Trypan Blue | 1992 |
Effect of congestive heart failure on clentiazem pharmacokinetics in a dog model.
Topics: Animals; Body Fluid Compartments; Calcium Channel Blockers; Diltiazem; Disease Models, Animal; Dogs; Heart Failure; Models, Biological | 1992 |
Pharmacological profile of a novel 1,5-benzothiazepine calcium antagonist.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Papillary Muscles; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Thiazepines | 1992 |
Effect of clentiazem on arterial pressure and renal function in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Infusions, Intravenous; Kidney; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium; Species Specificity | 1992 |
Inhibitory actions of diltiazem and its derivative, TA3090 on the Ba-current recorded from smooth muscle cells of the rabbit mesenteric artery.
Topics: Animals; Antihypertensive Agents; Barium; Diltiazem; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Channels; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Rabbits; Thiazepines | 1990 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
The effect of a new calcium channel blocker (TA-3090) on lipoprotein profile and intestinal lipid handling in rodents.
Topics: Animals; Calcium Channel Blockers; Cholesterol; Diltiazem; Drug Administration Schedule; Intestinal Absorption; Jejunum; Lipid Metabolism; Lipoproteins; Lymph; Male; Organ Culture Techniques; Rats; Rats, Inbred Strains; Triglycerides | 1992 |
Hemodynamic and metabolic effects of intravenous clentiazem in hypertensive patients.
Topics: Aged; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diltiazem; Female; Hemodynamics; Humans; Hypertension; Injections, Intravenous; Male; Middle Aged; Vascular Resistance | 1992 |
Effects of TA-3090, a new calcium channel blocker, on myocardial substrate utilization in ischemic and nonischemic isolated working fatty acid-perfused rat hearts.
Topics: Aerobiosis; Animals; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Fatty Acids; Glucose; Glycolysis; Heart; In Vitro Techniques; Male; Myocardium; Oxidation-Reduction; Palmitates; Rats; Reference Values | 1991 |
Clentiazem protects against chronic cerebral vasospasm in rabbit basilar artery.
Topics: Acetylcholine; Animals; Basilar Artery; Calcium Channel Blockers; Cerebral Angiography; Chronic Disease; Diltiazem; Dose-Response Relationship, Drug; Electric Stimulation; Ischemic Attack, Transient; Male; Rabbits; Sympathetic Nervous System | 1991 |
Effect of clentiazem on lipid profile, lipoprotein composition and aortic fatty streaks in cholesterol-fed rabbits.
Topics: Animals; Antihypertensive Agents; Aorta; Aortic Diseases; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Diltiazem; Lipid Metabolism; Lipids; Lipoproteins; Male; Rabbits; Triglycerides | 1991 |
Relationship between the cardiovascular effects and both plasma and myocardial levels of clentiazem, a new benzothiazepine calcium antagonist, in anesthetized dogs.
Topics: Animals; Calcium Channel Blockers; Cardiovascular System; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Male; Myocardium | 1991 |
Differential effect of diltiazem and TA-3090 on calcium homeostasis of neutrophils.
Topics: Calcium; Calcium Channel Blockers; Cytochalasin B; Diltiazem; Homeostasis; Humans; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Second Messenger Systems; Superoxides; Thiazepines | 1991 |
Block of neuronal Ca++ influx by the anti-ischemic agent TA3090.
Topics: Animals; Antihypertensive Agents; Calcium; Cells, Cultured; Diltiazem; Electric Stimulation; Ganglia, Spinal; Membrane Potentials; Neurons; Rats; Rats, Inbred Strains | 1991 |
Vascular actions of TA 3090, a novel analog of diltiazem: interaction with endothelium-dependent relaxation in canine femoral and coronary arteries.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dogs; Endothelium, Vascular; Female; Femoral Artery; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide | 1991 |
Synthesis of halogen-substituted 1,5-benzothiazepine derivatives and their vasodilating and hypotensive activities.
Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Chemical Phenomena; Chemistry; Coronary Circulation; Diltiazem; Dogs; Guinea Pigs; Male; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship; Thiazepines | 1991 |
Clentiazem reduces infarct size in rabbit middle cerebral artery occlusion.
Topics: Acetylcholine; Animals; Arterial Occlusive Diseases; Brain; Cerebral Arteries; Cerebral Infarction; Diltiazem; Dose-Response Relationship, Drug; Female; Histamine; Male; Norepinephrine; Rabbits; Thiazepines; Vasoconstriction; Vasodilation | 1991 |
Peripheral vasodilator and cardiac properties of the 1,5-benzothiazepine calcium antagonist analog, TA-3090, in dogs.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Diltiazem; Dogs; Dose-Response Relationship, Drug; Heart; Hemodynamics; Vasodilator Agents | 1991 |
Binding characteristics of a new 1,5-benzothiazepine, clentiazem, to rat cerebral cortex and skeletal muscle membranes.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Cerebral Cortex; Diltiazem; Male; Membranes; Muscles; Nitrendipine; Radioligand Assay; Rats; Rats, Inbred Strains; Stereoisomerism; Tritium | 1991 |
In-vitro study of the effect of clentiazem on rabbit aorta and on myocardium.
Topics: Animals; Aorta; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Female; Heart; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardium; Potassium Chloride; Rabbits; Thiazepines; Time Factors | 1990 |
Mechanism of action of clentiazem on human coronary artery and myocardium.
Topics: Adolescent; Adult; Antihypertensive Agents; Calcium Channel Blockers; Child; Coronary Vessels; Depression, Chemical; Diltiazem; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Middle Aged; Myocardial Contraction; Thiazepines; Vasodilation | 1990 |
Suppression of water shift into intracellular space by TA-3090 (calcium entry blocker) measured with NMR.
Topics: Animals; Body Water; Calcium Channel Blockers; Diltiazem; Intracellular Fluid; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Inbred Strains | 1990 |
The diltiazem analog TA-3090 mimics the actions of high extracellular Ca2+ on parathyroid function in dispersed bovine parathyroid cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cattle; Cells, Cultured; Cyclic AMP; Cytosol; Diltiazem; Dopamine; Magnesium; Parathyroid Glands; Parathyroid Hormone; Thiazepines; Virulence Factors, Bordetella | 1990 |
Comparison of converting enzyme inhibitor and calcium channel blocker in hypertensive glomerular injury.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Captopril; Diltiazem; Glomerular Filtration Rate; Hypertension; Kidney Failure, Chronic; Kidney Glomerulus; Male; Nephrectomy; Proteinuria; Rats; Rats, Inbred Strains; Thiazepines; Triglycerides | 1990 |
[3H]TA-3090, a selective benzothiazepine-type calcium channel receptor antagonist: in vitro characterization.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Culture Techniques; Diltiazem; Heart; Male; Myocardium; Rats; Rats, Inbred Strains; Thiazepines; Tritium | 1990 |
High-performance liquid chromatographic method for the assay of TA-3090 and its pharmacokinetic parameters in healthy volunteers.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Half-Life; Humans; Spectrophotometry, Ultraviolet | 1989 |
Metabolic fate of the new Ca++-channel blocking agent (+)-(2S,3S)-3-acetoxy-8-chloro-(2-(dimethylamino)ethyl)-2,3-dihydro- 2-(4-methoxyphenyl)-2,5-benzothiazepin-4-(5H)-one maleate. Distribution, excretion and protein binding in rats and dogs.
Topics: Animals; Autoradiography; Bile; Biotransformation; Calcium Channel Blockers; Diltiazem; Dogs; Enterohepatic Circulation; Feces; Gas Chromatography-Mass Spectrometry; Male; Protein Binding; Rats; Rats, Inbred Strains; Thiazepines; Tissue Distribution | 1989 |
Pharmacology of TA-3090 (8-chloro diltiazem) related to its cerebrovascular protective properties.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Cerebral Arteries; Cerebrovascular Circulation; Diltiazem; Dose-Response Relationship, Drug; Female; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Rabbits; Renal Artery; Thiazepines; Thrombin | 1989 |
Inhibitory actions of a novel benzothiazepine derivative, TA3090, on the electrical and mechanical responses of the rabbit mesenteric artery.
Topics: Action Potentials; Animals; Calcium; Diltiazem; Electric Stimulation; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Norepinephrine; Potassium; Rabbits; Thiazepines; Vasodilation; Vasomotor System | 1989 |
Long-lasting hypotensive and antihypertensive effects of a new 1,5-benzothiazepine calcium antagonist in hypertensive rats and renal hypertensive dogs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Desoxycorticosterone; Diltiazem; Dogs; Electrocardiography; Electrolytes; Heart Rate; Hypertension; Hypertension, Renal; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Thiazepines | 1988 |
Immediate and prolonged hemodynamic effects of TA-3090 on spontaneously hypertensive (SHR) and normal Wistar-Kyoto (WKY) rats.
Topics: Animals; Antihypertensive Agents; Diltiazem; Hemodynamics; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thiazepines | 1988 |
Calcium antagonistic and spasmolytic activities of a new 1,5-benzothiazepine derivative in isolated canine and monkey arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Dinoprost; Dogs; Female; In Vitro Techniques; Macaca fascicularis; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxyhemoglobins; Parasympatholytics; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; Serotonin; Thiazepines | 1988 |
Hemodynamic comparison of diltiazem and TA-3090 in spontaneously hypertensive and normal Wistar-Kyoto rats.
Topics: Animals; Cerebrovascular Circulation; Coronary Circulation; Diltiazem; Hemodynamics; Hypertension; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Thiazepines; Vascular Resistance | 1988 |
Cardiovascular effects of a new 1,5-benzothiazepine calcium antagonist in anesthetized dogs.
Topics: Animals; Calcium Channel Blockers; Cardiac Output; Coronary Circulation; Diltiazem; Dogs; Female; Hemodynamics; Injections, Intra-Arterial; Injections, Intravenous; Male; Myocardial Contraction; Regional Blood Flow; Splanchnic Circulation; Thiazepines | 1988 |
Enantiomeric separation of diltiazem, clentiazem, and its related compounds by capillary electrophoresis using polysaccharides.
Topics: beta-Cyclodextrins; Calcium Channel Blockers; Chondroitin Sulfates; Chromatography, Affinity; Cyclodextrins; Dextran Sulfate; Diltiazem; Electrochemistry; Electrophoresis, Capillary; Heparin; Polysaccharides; Stereoisomerism | 1995 |
Effect of clentiazem (TA-3090) with posttreatment on neurologic and histologic disorders of stroke-prone spontaneously hypertensive rats with history of stroke.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Brain; Cerebrovascular Disorders; Diltiazem; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Kidney; Nervous System; Rats; Rats, Inbred SHR; Sodium, Dietary | 1994 |
Sexual dimorphism in the metabolic response to the calcium channel antagonists, diltiazem and clentiazem, by hyperlipidemic JCR:LA-cp rats.
Topics: Animals; Body Weight; Calcium Channel Blockers; Diltiazem; Female; Glucose; Hyperlipidemias; Insulin; Lipids; Lipoproteins; Male; Rats; Rats, Mutant Strains; Sex Factors | 1995 |
Ameliorating effect of clentiazem (TA-3090), a new Ca antagonist, on the impaired learning ability of poststroke SHRSP.
Topics: Amnesia; Animals; Avoidance Learning; Calcium Channel Blockers; Cerebrovascular Disorders; Diltiazem; Disease Susceptibility; Learning Disabilities; Male; Rats; Rats, Inbred SHR | 1995 |
Sustained myocardial protection by clentiazem (TA-3090) after a 90-minute coronary occlusion and 72 hours of reperfusion in dogs with collateral flow.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Collateral Circulation; Coronary Vessels; Diltiazem; Dogs; Evans Blue; Female; Male; Microspheres; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium | 1993 |
Positive ion EI mass spectra of 2,3,5-trisubstituted-1,5-benzothiazepines, diltiazem, clentiazem and their fat-soluble metabolites.
Topics: Animals; Diltiazem; Dogs; Fats; Gas Chromatography-Mass Spectrometry; Molecular Structure; Rats; Solubility | 1994 |
Clentiazem, diltiazem, and cold cardioplegia in isolated ischemic rabbit hearts: relation between additive cardioprotection, physicochemical properties, and preservation of myocardial lipid components.
Topics: Animals; Antihypertensive Agents; Cardioplegic Solutions; Cold Temperature; Coronary Circulation; Diltiazem; Lipid Metabolism; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rabbits | 1994 |
Effects of different antihypertensive treatments on morphologic progression of diabetic nephropathy in uninephrectomized dogs.
Topics: Animals; Antihypertensive Agents; Diabetic Nephropathies; Diltiazem; Dogs; Drug Therapy, Combination; Fibrosis; Glomerular Mesangium; Glomerulosclerosis, Focal Segmental; Lisinopril; Nephrectomy; Nephritis, Interstitial | 1994 |
Inhibitory effect of clentiazem (TA-3090) on platelet aggregation--alone and in combination with aspirin or ticlopidine.
Topics: Animals; Aspirin; Calcium Channel Blockers; Diltiazem; Drug Synergism; Drug Therapy, Combination; Humans; Male; Molecular Structure; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Ticlopidine | 1994 |
Synthesis of the metabolites of clentiazem.
Topics: Animals; Biotransformation; Calcium Channel Blockers; Diltiazem; Dogs; Magnetic Resonance Spectroscopy; Rats | 1994 |
Clentiazem given at reperfusion improves subendocardial reflow and reduces myocardial infarct size in the dog.
Topics: Animals; Calcium Channel Blockers; Collateral Circulation; Coronary Circulation; Diltiazem; Dogs; Female; Hemodynamics; Leukocyte Count; Male; Myocardial Infarction; Myocardial Reperfusion; Neutrophils | 1994 |
Comparison of atherogenicity of soybean oil and peanut oil, and effect of clentiazem on diet-induced atherosclerosis in rabbits.
Topics: Analysis of Variance; Animals; Aorta, Abdominal; Aorta, Thoracic; Arachis; Arteriosclerosis; Cholesterol; Collagen; Diet, Atherogenic; Diltiazem; Male; Peanut Oil; Phospholipids; Plant Oils; Platelet Aggregation Inhibitors; Rabbits; Soybean Oil; Triglycerides | 1994 |
Effects of clentiazem on cerebral ischemia induced by carotid artery occlusion in stroke-prone spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Antihypertensive Agents; Arterial Occlusive Diseases; Blood Pressure; Brain; Brain Ischemia; Carbon Dioxide; Carotid Artery Diseases; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cerebrovascular Disorders; Diltiazem; Disease Susceptibility; Electroencephalography; Energy Metabolism; Heart Rate; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Oxygen; Partial Pressure; Phosphocreatine; Rats; Rats, Inbred SHR; Regional Blood Flow; Time Factors; Tissue Distribution | 1994 |
Immunosuppressive properties of the benzothiazepine calcium antagonists diltiazem and clentiazem, with and without cyclosporine, in heterotopic rat heart transplantation.
Topics: Animals; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Therapy, Combination; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Rats; Rats, Inbred Lew; Rats, Inbred WF; Time Factors; Transplantation, Heterotopic; Transplantation, Homologous; Transplantation, Isogeneic | 1993 |
Inhibitory effect of clentiazem (TA-3090), a new calcium antagonist, on balloon catheter-induced intimal thickening of rabbit aorta.
Topics: Animals; Aortic Diseases; Arteriosclerosis; Calcium Channel Blockers; Catheterization; Cell Division; Cells, Cultured; Collagen; Diet, Atherogenic; Diltiazem; Disease Models, Animal; Lipids; Male; Muscle, Smooth, Vascular; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits | 1993 |
Role of endothelium in the mechanical response of the carotid arterial wall to calcium blockade in spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Animals; Arteries; Calcium Channel Blockers; Carotid Arteries; Compliance; Diltiazem; Endothelium, Vascular; Hypertension; In Vitro Techniques; Muscle, Smooth, Vascular; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1993 |
Long-term effects of antihypertensive regimens on renal hemodynamics and proteinuria.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Diltiazem; Dipeptides; Dogs; Drug Therapy, Combination; Female; Glomerular Filtration Rate; Hemodynamics; Homeostasis; Kidney; Lisinopril; Male; Proteinuria; Renal Circulation | 1993 |
Protective effect of clentiazem against epinephrine-induced cardiac injury in rats.
Topics: Animals; Body Weight; Calcium Channel Blockers; Calcium Channels; Cardiomyopathies; Diltiazem; Endomyocardial Fibrosis; Epinephrine; Heart; Heart Ventricles; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1993 |
Metabolism of clentiazem in rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Bile; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Gas Chromatography-Mass Spectrometry; Male; Rats; Rats, Sprague-Dawley | 1993 |
Disposition and metabolic fate of clentiazem in rats and dogs.
Topics: Animals; Biotransformation; Diltiazem; Dogs; Feces; Female; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sex Characteristics | 1993 |
The effect of a new calcium antagonist, TA3090 (clentiazem), on experimental transient focal cerebral ischemia in cats.
Topics: Animals; Brain; Calcium; Cats; Cerebral Infarction; Diltiazem; Disease Models, Animal; Female; Ischemic Attack, Transient; Male; Pia Mater; Regional Blood Flow | 1993 |
Resistance of the failing dystrophic hamster heart to the cardioprotective effects of diltiazem and clentiazem: evidence of coronary vascular dysfunctions.
Topics: Animals; Calcium Channel Blockers; Coronary Vessels; Cricetinae; Diltiazem; Heart; Heart Failure | 1995 |
Pharmacodynamics and pharmacokinetics of clentiazem and diltiazem in closed-chest anesthetized dogs.
Topics: Analysis of Variance; Anesthesia, General; Animals; Baroreflex; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Chromatography, High Pressure Liquid; Diltiazem; Dogs; Female; Half-Life; Heart Rate; Injections, Intravenous; Male; Myocardium; Stroke Volume; Tissue Distribution; Vascular Resistance | 1995 |
Electrophysiological effects of clentiazem, a new Ca2+ antagonist, on rabbit hearts.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Diltiazem; Heart Conduction System; In Vitro Techniques; Rabbits | 1996 |
Inhibition of vascular smooth muscle cell proliferation by the calcium antagonist clentiazem: role of protein kinase C.
Topics: Adenosine Monophosphate; Animals; Aorta; Calcium Channel Blockers; Cell Division; Cell Line; Cholesterol Esters; Diltiazem; DNA; In Vitro Techniques; Isoenzymes; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Phosphorylation; Protein Kinase C; Rats | 1996 |
Inhibition of PDGF-mediated proliferation of vascular smooth muscle cells by calcium antagonists.
Topics: Animals; Calcium Channel Blockers; Cell Division; Cells, Cultured; Diltiazem; DNA Replication; Growth Inhibitors; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Muscle, Smooth, Vascular; Myristoylated Alanine-Rich C Kinase Substrate; Nifedipine; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Protein Processing, Post-Translational; Proteins; Rats; Transcription Factor AP-1; Verapamil | 1997 |
Coronary and cardiac sensitivity to the vasoselective benzothiazepine-like calcium antagonist, clentiazem, in experimental heart failure.
Topics: Animals; Body Weight; Calcium Channel Blockers; Chronic Disease; Coronary Vessels; Cricetinae; Cyclooxygenase Inhibitors; Diltiazem; Enzyme Inhibitors; Heart; Heart Failure; In Vitro Techniques; Indomethacin; Mesocricetus; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase | 1997 |
Mechanism for the cardioprotective effects of the calcium channel blocker clentiazem during ischemia and reperfusion.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Ferrets; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury | 1998 |
Immunomodulating effects of second-generation calcium channel blockers on experimental heart transplantation.
Topics: Adjuvants, Immunologic; Amlodipine; Animals; Benzimidazoles; Calcium Channel Blockers; Cyclosporine; Diltiazem; Drug Therapy, Combination; Felodipine; Graft Survival; Heart Transplantation; Immunosuppressive Agents; Male; Mibefradil; Rats; Rats, Inbred Lew; Tetrahydronaphthalenes; Time Factors | 1999 |
Sex-related differences in the renal disposition of the acidic metabolite of clentiazem in rat.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diltiazem; Female; Folic Acid Antagonists; Kidney; Male; Methotrexate; Probenecid; Protein Binding; Rats; Rats, Sprague-Dawley; Renal Agents; Sex Characteristics | 2001 |
Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem.
Topics: Diltiazem; Esters; Stereoisomerism | 2022 |