Page last updated: 2024-08-23

diltiazem and caffeine

diltiazem has been researched along with caffeine in 68 studies

Research

Studies (68)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (26.47)	18.7374
1990's	15 (22.06)	18.2507
2000's	23 (33.82)	29.6817
2010's	11 (16.18)	24.3611
2020's	1 (1.47)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Coassolo, P; Lavé, T; Schneider, G	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Abdel-Maksoud, MS; Ali, EMH; Ammar, UM; Choi, HS; El-Gamal, MI; Gamal El-Din, MM; Han, DK; Jeon, HR; Kim, G; Kwon, D; Kwon, YJ; Lee, BS; Lee, JK; Lee, KH; Lee, KT; Mersal, KI; Oh, CH; Yoo, KH	1
Hu, Q; Kunda, K; Sturek, M	1
Asayama, J; Inoue, D; Inoue, M; Matsumoto, T; Miyazaki, H; Nakagawa, M; Omori, I; Tatsumi, T; Yamahara, Y	1
Sturek, M; Wagner-Mann, C	1
Fabrègues, E; John, GW; Kamal, M; Massingham, R	1
Higham, S; Kraus-Friedmann, N; Pressley, TA; Shoshan-Barmatz, V	1
Asayama, J; Inoue, D; Miyazaki, H; Nakagawa, M; Omori, I; Shirayama, T; Tatsumi, T	1
Hilton, PJ; Poston, L; Woolfson, RG	1
Auclair, MC; Lechat, P; Vernimmen, C	1
Denborough, MA; Foster, PS; Hopkinson, KC	1
Kai, H; Kanaide, H; Nakamura, M	1
Røed, A	1
Denborough, MA; Foster, PS	2
Dacquet, C; Mironneau, C; Mironneau, J	1
Hester, RK; Satake, N; Shibata, S; Tomiyama, A; Ueda, S; Wakabayashi, S	1
Hasegawa, M; Kanaide, H; Kobayashi, S; Matsumoto, T; Nakamura, M; Nishimura, J; Shogakiuchi, Y	1
Uski, TK	1
Dozier, SE; Fulfer, RT; Ilias, WK; Williams, CH	1
Hirata, M; Inamitsu, T	1
Endo, M; Ishizuka, T	1
Auclair, MC; Vernimmen, C	1
Ishide, N; Takishima, T; Watanabe, H	1
Aoyama, T; Ono, H; Sato, T	1
Fujiwara, S; Kuriyama, H	1
Itoh, T; Kuriyama, H; Nanjo, T	1
Hirano, K; Kanaide, H; Watanabe, C	1
Hiroishi, G; Inomata, H; Kanaide, H; Kobayashi, S; Nishimura, J	1
Kwan, CY; Wang, HX; Wong, TM	1
Dohi, T; Kitayama, S; Morita, K	1
Hensel, M; Kox, WJ; Mäding, K; Volk, T	1
Knot, HJ; Nelson, MT; Standen, NB	1
Aaronson, PI; Hague, D; Robertson, TP; Ward, JP	1
Anselmi, E; Bermejo, A; Cabedo, N; Catret, M; Cortes, D; D'Ocon, P; Elorriaga, M; Ivorra, MD; Magraner, J; Tur, R	1
Ferreyra, C; Ortiz, C	1
Asbun, J; Castillo, EF; Ceballos, G; del Carmen Castillo, M; Henkel, CC	1
Ochs, RS; Wingertzahn, MA	1
Barclay, JK; Murrant, CL; Reading, SA	1
Cheranov, SY; Jaggar, JH	1
Dierkes, PW; Hochstrate, P; Schlue, WR; Wende, V	1
Balasubramaniam, R; Chawla, S; Grace, AA; Huang, CL	1
Adebiyi, A; Jaggar, JH; Leffler, CW; Li, A	1
Du, L; Shen, J; Wang, W; Wang, Z; Xing, D; Yip, S	1
Benotti, MJ; Brownawell, BJ	1
Aragon, CM; Baliño, P; Pastor, R	1
Cadet-Taïrou, A; Evrard, I; Legleye, S	1

Reviews

1 review(s) available for diltiazem and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

67 other study(ies) available for diltiazem and caffeine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Discovery of New Imidazo[2,1- Journal of medicinal chemistry, 2021, 05-27, Volume: 64, Issue:10 Topics: Animals; Binding Sites; Cell Line, Tumor; Cell Proliferation; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Drug Stability; Half-Life; Humans; Imidazoles; Melanoma; Mice; Mitogen-Activated Protein Kinase Kinases; Molecular Docking Simulation; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Structure-Activity Relationship; Sulfonamides; Thiazoles; Transplantation, Heterologous	2021
Sarcoplasmic reticulum buffering of myoplasmic calcium in bovine coronary artery smooth muscle. The Journal of physiology, 1992, Volume: 451 Topics: Animals; Buffers; Caffeine; Calcium; Cattle; Coronary Vessels; Diltiazem; Extracellular Space; Fura-2; In Vitro Techniques; Ion Transport; Muscle, Smooth, Vascular; Myofibrils; Potassium; Sarcoplasmic Reticulum	1992
[Effects of ouabain, caffeine, and diltiazem, on spontaneous cyclic Ca2+ release from sarcoplasmic reticulum in the skinned papillary muscles of guinea pigs]. Kokyu to junkan. Respiration & circulation, 1991, Volume: 39, Issue:11 Topics: Animals; Caffeine; Calcium; Diltiazem; Guinea Pigs; In Vitro Techniques; Myocardial Contraction; Ouabain; Papillary Muscles; Sarcoplasmic Reticulum	1991
Endothelin mediates Ca influx and release in porcine coronary smooth muscle cells. The American journal of physiology, 1991, Volume: 260, Issue:4 Pt 1 Topics: Animals; Caffeine; Calcium; Calcium Channels; Coronary Vessels; Diltiazem; Endothelins; In Vitro Techniques; Kinetics; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Potassium; Sarcoplasmic Reticulum; Swine	1991
Caffeine-induced contractions in rabbit isolated renal artery are differentially inhibited by calcium antagonists. European journal of pharmacology, 1991, Apr-24, Volume: 196, Issue:3 Topics: Animals; Bepridil; Caffeine; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Fendiline; Flunarizine; Kinetics; Lidoflazine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Rabbits; Renal Artery; Verapamil	1991
Characterization of high-affinity ryanodine-binding sites of rat liver endoplasmic reticulum. Differences between liver and skeletal muscle. The Biochemical journal, 1991, May-15, Volume: 276 ( Pt 1) Topics: Animals; Base Sequence; Caffeine; Cells, Cultured; Dantrolene; Diltiazem; Endoplasmic Reticulum; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Microsomes, Liver; Molecular Sequence Data; Muscles; Oligonucleotide Probes; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sodium Chloride	1991
Effect of diltiazem on spontaneous cyclic Ca2+ release from sarcoplasmic reticulum. European journal of pharmacology, 1990, Jan-17, Volume: 175, Issue:3 Topics: Animals; Caffeine; Calcium; Diltiazem; Egtazic Acid; Guinea Pigs; Heart; In Vitro Techniques; Myocardial Contraction; Myocardium; Sarcoplasmic Reticulum	1990
Effects of ouabain and low sodium on contractility of human resistance arteries. Hypertension (Dallas, Tex. : 1979), 1990, Volume: 15, Issue:6 Pt 1 Topics: Arteries; Caffeine; Calcium; Diltiazem; Dose-Response Relationship, Drug; Humans; Muscle Contraction; Muscle Tonus; Muscle, Smooth, Vascular; Ouabain; Phentolamine; Sodium; Sodium-Potassium-Exchanging ATPase; Vascular Resistance	1990
[Effect of substances modifying calcium movement on the contractility of cultured cardiac cells]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1985, Volume: 179, Issue:1 Topics: Animals; Caffeine; Calcium Channel Blockers; Cells, Cultured; Diltiazem; Histamine; Imipramine; Ion Channels; Isoproterenol; Myocardial Contraction; Nifedipine; Phenylephrine; Rats; Verapamil	1985
Effect of diltiazem, verapamil and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible human skeletal muscle. Clinical and experimental pharmacology & physiology, 1989, Volume: 16, Issue:10 Topics: Caffeine; Dantrolene; Diltiazem; Disease Susceptibility; Halothane; Humans; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Verapamil	1989
Endothelin-sensitive intracellular Ca2+ store overlaps with caffeine-sensitive one in rat aortic smooth muscle cells in primary cultures. Biochemical and biophysical research communications, 1989, Jan-16, Volume: 158, Issue:1 Topics: Aminoquinolines; Animals; Aorta; Caffeine; Calcium; Cells, Cultured; Diltiazem; Endothelins; Endothelium, Vascular; Fluorescent Dyes; Kinetics; Muscle, Smooth, Vascular; Peptides; Rats	1989
Ca antagonistic and non-specific effects of diltiazem on the rat phrenic nerve diaphragm preparation. European journal of pharmacology, 1989, Jan-02, Volume: 159, Issue:1 Topics: Action Potentials; Animals; Caffeine; Calcium Channel Blockers; Calcium Chloride; Diltiazem; Electromyography; Female; In Vitro Techniques; Male; Muscle Contraction; Phrenic Nerve; Potassium Chloride; Rats; Rats, Inbred Strains; Respiratory Muscles; Sarcolemma	1989
Effect of diltiazem and dantrolene on the contractility of isolated malignant hyperpyrexia-susceptible porcine skeletal muscle. British journal of anaesthesia, 1989, Volume: 62, Issue:5 Topics: Animals; Caffeine; Dantrolene; Diltiazem; Dose-Response Relationship, Drug; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Potassium Chloride; Swine	1989
Effects of calcium entry blockers on calcium-dependent contractions of rat portal vein. British journal of pharmacology, 1987, Volume: 92, Issue:1 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; In Vitro Techniques; Isradipine; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Portal Vein; Potassium; Rats; Rats, Inbred Strains	1987
Mode of vasorelaxing action of 5-[3-[[2-(3,4-dimethoxyphenyl)-ethyl]amino]-1-oxopropyl]-2,3,4,5- tetrahydro-1,5-benzothiazepine fumarate (KT-362), a new intracellular calcium antagonist. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1 Topics: Animals; Caffeine; Calcium Channel Blockers; Diltiazem; Egtazic Acid; Gallopamil; Lanthanum; Male; Methoxamine; Muscle Contraction; Nifedipine; Nitroglycerin; Norepinephrine; Rabbits; Thiazepines; Vasodilation; Verapamil	1987
Quin2 microfluorometry and effects of verapamil and diltiazem on calcium release from rat aorta smooth muscle cells in primary culture. Circulation research, 1988, Volume: 63, Issue:1 Topics: Aminoquinolines; Animals; Aorta; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytosol; Diltiazem; Male; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Norepinephrine; Rats; Verapamil	1988
Cellular calcium and the contraction induced by prostaglandin F2 alpha in feline cerebral arteries. Acta pharmacologica et toxicologica, 1985, Volume: 56, Issue:2 Topics: Animals; Buffers; Caffeine; Calcium; Calcium Channel Blockers; Cats; Cerebral Arteries; Diltiazem; Dinoprost; Egtazic Acid; In Vitro Techniques; Manganese; Neuraminidase; Prostaglandins F; Vasoconstriction	1985
Diltiazem inhibits halothane-induced contractions in malignant hyperthermia-susceptible muscles in vitro. British journal of anaesthesia, 1985, Volume: 57, Issue:10 Topics: Animals; Benzazepines; Caffeine; Depression, Chemical; Diltiazem; Disease Susceptibility; Halothane; In Vitro Techniques; Malignant Hyperthermia; Muscle Contraction; Swine; Time Factors	1985
Effect of diltiazem on the release of calcium from the canine fragmented cardiac sarcoplasmic reticulum. Japanese journal of pharmacology, 1983, Volume: 33, Issue:5 Topics: Animals; Benzazepines; Caffeine; Calcium; Calcium-Transporting ATPases; Diltiazem; Dogs; Female; In Vitro Techniques; Male; Myocardium; Sarcoplasmic Reticulum	1983
Effects of diltiazem on skinned skeletal muscle fibers of the African clawed toad. Circulation research, 1983, Volume: 52, Issue:2 Pt 2 Topics: Animals; Benzazepines; Caffeine; Calcium; Diltiazem; Egtazic Acid; In Vitro Techniques; Muscle Contraction; Muscles; Sarcoplasmic Reticulum; Xenopus laevis	1983
Influence of rat serum on cultured newborn rat heart cell inotropism. Developmental pharmacology and therapeutics, 1984, Volume: 7 Suppl 1 Topics: Animals; Animals, Newborn; Blood; Caffeine; Calcium; Cells, Cultured; Diltiazem; Myocardial Contraction; Myocardium; Nifedipine; Rats	1984
Effects of high-K low-Na, diltiazem, caffeine and Ba on spontaneous fluctuating contractile activities in rat cardiac muscle. The Tohoku journal of experimental medicine, 1984, Volume: 144, Issue:4 Topics: Animals; Barium; Benzazepines; Caffeine; Calcium; Diltiazem; In Vitro Techniques; Male; Myocardial Contraction; Potassium; Rats; Rats, Inbred Strains; Sarcoplasmic Reticulum; Sodium	1984
Mechanisms of slow contracture induced by potassium and caffeine in skeletal muscle of the dog. Japanese journal of pharmacology, 1984, Volume: 34, Issue:2 Topics: Animals; Caffeine; Calcium Chloride; Chlorides; Diltiazem; Dogs; Kinetics; Manganese; Manganese Compounds; Muscle Contraction; Potassium; Potassium Chloride; Tetracaine; Verapamil	1984
Effects of agents that modulate potassium permeability on smooth muscle cells of the guinea-pig basilar artery. British journal of pharmacology, 1983, Volume: 79, Issue:1 Topics: 4-Aminopyridine; Acetylcholine; Aminopyridines; Animals; Basilar Artery; Caffeine; Diltiazem; Female; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Muscle, Smooth, Vascular; Permeability; Potassium; Procaine; Tetraethylammonium; Tetraethylammonium Compounds	1983
Effects of calcium and manganese ions on mechanical properties of intact and skinned muscles from the guinea-pig stomach. The Journal of physiology, 1982, Volume: 333 Topics: Acetylcholine; Action Potentials; Animals; Caffeine; Calcium; Diltiazem; Female; Guinea Pigs; In Vitro Techniques; Male; Manganese; Muscle Contraction; Muscle, Smooth; Procaine; Stomach	1982
The effect of calcium channel antagonists and BAY K 8644 on calcium fluxes of malignant hyperpyrexia-susceptible muscle. The International journal of biochemistry, 1993, Volume: 25, Issue:4 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Diltiazem; Halothane; Malignant Hyperthermia; Muscle Contraction; Muscles; Nifedipine; Potassium Chloride; Sarcoplasmic Reticulum; Swine; Verapamil	1993
Role of extracellular and intracellular sources of Ca2+ in sarafotoxin S6b-induced contraction of strips of the rat aorta. British journal of pharmacology, 1993, Volume: 108, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta, Thoracic; Caffeine; Calcium; Cytosol; Diltiazem; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Rats; Rats, Wistar; Spectrometry, Fluorescence; Vasoconstrictor Agents; Viper Venoms	1993
Differential effects of diltiazem and nitroglycerin on cytosolic Ca2+ concentration and on force in the bovine ophthalmic artery. Investigative ophthalmology & visual science, 1996, Volume: 37, Issue:13 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Cattle; Cytosol; Diltiazem; Female; Fura-2; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Ophthalmic Artery; Phosphodiesterase Inhibitors; Serotonin; Vasodilator Agents	1996
Tetrandrine inhibits electrically induced [Ca2+]i transient in the isolated single rat cardiomyocyte. European journal of pharmacology, 1997, Jan-14, Volume: 319, Issue:1 Topics: Alkaloids; Animals; Benzylisoquinolines; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; Electric Stimulation; Heart; In Vitro Techniques; Potassium Chloride; Rats; Rats, Sprague-Dawley; Ryanodine; Sodium; Thapsigargin; Verapamil	1997
Stimulation of cyclic ADP-ribose synthesis by acetylcholine and its role in catecholamine release in bovine adrenal chromaffin cells. The Journal of biological chemistry, 1997, Aug-22, Volume: 272, Issue:34 Topics: Acetylcholine; Adenosine Diphosphate Ribose; ADP-ribosyl Cyclase; ADP-ribosyl Cyclase 1; Animals; Antigens, CD; Antigens, Differentiation; Caffeine; Calcium; Calcium Channel Blockers; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Cyclic ADP-Ribose; Diltiazem; Enzyme Activation; Inositol 1,4,5-Trisphosphate; N-Glycosyl Hydrolases; Ryanodine; Scorpion Venoms; Thapsigargin	1997
Nitric oxide induces transient Ca2+ changes in endothelial cells independent of cGMP. Journal of cellular physiology, 1997, Volume: 172, Issue:3 Topics: Adenosine Triphosphate; Caffeine; Calcium; Cell Line; Cyclic GMP; Dantrolene; Diltiazem; Endothelium, Vascular; Enzyme Activation; Guanylate Cyclase; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Nitric Oxide; Nitroprusside; Penicillamine; Procaine; Ryanodine; S-Nitroso-N-Acetylpenicillamine; Thapsigargin	1997
Ryanodine receptors regulate arterial diameter and wall [Ca2+] in cerebral arteries of rat via Ca2+-dependent K+ channels. The Journal of physiology, 1998, Apr-01, Volume: 508 ( Pt 1) Topics: Animals; Caffeine; Calcium Channel Blockers; Cerebral Arteries; Diltiazem; Endothelium, Vascular; Female; In Vitro Techniques; Kinetics; Membrane Potentials; Microscopy, Video; Models, Cardiovascular; Muscle, Smooth, Vascular; Nimodipine; Peptides; Potassium Channels; Potassium Channels, Tandem Pore Domain; Rats; Rats, Sprague-Dawley; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Time Factors; Vasoconstriction	1998
Voltage-independent calcium entry in hypoxic pulmonary vasoconstriction of intrapulmonary arteries of the rat. The Journal of physiology, 2000, Jun-15, Volume: 525 Pt 3 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Chelating Agents; Diltiazem; Dinucleoside Phosphates; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Hypoxia; Imidazoles; In Vitro Techniques; Ion Channel Gating; Lanthanum; Male; Membrane Potentials; Nifedipine; Phosphodiesterase Inhibitors; Pulmonary Artery; Pulmonary Circulation; Rats; Rats, Wistar; Ryanodine; Thapsigargin; Vasoconstriction; Verapamil	2000
Mechanism of vascular relaxation by thaligrisine: functional and binding assays. Life sciences, 2000, Aug-18, Volume: 67, Issue:13 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; Aorta, Thoracic; Arteries; Binding Sites; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Diltiazem; Female; In Vitro Techniques; Membranes; Muscle Relaxation; Muscle, Smooth, Vascular; Nitrendipine; Norepinephrine; Potassium Chloride; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Tail; Trees; Tritium; Vasoconstrictor Agents	2000
Analysis of multicomponent formulations containing phenylpropanolamine hydrochloride, caffeine and diazepam by using LC. Journal of pharmaceutical and biomedical analysis, 2001, Volume: 25, Issue:3-4 Topics: Caffeine; Chromatography, High Pressure Liquid; Diltiazem; Phenylpropanolamine; Tablets	2001
Relationship between extra and intracellular sources of calcium and the contractile effect of thiopental in rat aorta. Canadian journal of physiology and pharmacology, 2001, Volume: 79, Issue:5 Topics: Animals; Aorta; Caffeine; Calcium; Calcium Channel Blockers; Diltiazem; Endothelium, Vascular; Hypnotics and Sedatives; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Rats; Rats, Wistar; Thiopental; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Verapamil	2001
Changes in ryanodine receptor-mediated calcium release during skeletal muscle differentiation. II. Resolution of a caffeine-ryanodine paradox. Experimental biology and medicine (Maywood, N.J.), 2001, Volume: 226, Issue:2 Topics: Animals; Biological Transport; Caffeine; Calcium; Calcium Channel Blockers; Cell Differentiation; Cell Line; Cell Membrane; Diltiazem; Electric Conductivity; Flunarizine; Inositol 1,4,5-Trisphosphate; Ion Channels; Muscle, Skeletal; Rats; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum	2001
Increased cAMP as a positive inotropic factor for mammalian skeletal muscle in vitro. Canadian journal of physiology and pharmacology, 2003, Volume: 81, Issue:10 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic beta-Agonists; Animals; Bucladesine; Caffeine; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Cyclic AMP; Dantrolene; Diltiazem; In Vitro Techniques; Isometric Contraction; Isoproterenol; Male; Mice; Muscle Relaxants, Central; Muscle, Skeletal; Sarcolemma; Sarcoplasmic Reticulum; Time Factors	2003
Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries. The Journal of physiology, 2004, May-01, Volume: 556, Issue:Pt 3 Topics: Animals; Bongkrekic Acid; Caffeine; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Calcium-Binding Proteins; Calcium-Transporting ATPases; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Arteries; Clonazepam; Cyclosporine; Diltiazem; Female; Hydrogen Peroxide; Indazoles; Ion Channels; Male; Membrane Potentials; Microscopy, Confocal; Mitochondria, Muscle; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Smooth Muscle; Oligomycins; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Rhodamines; Rotenone; Ruthenium Compounds; Sarcoplasmic Reticulum; Sodium-Calcium Exchanger; Thapsigargin; Thiazepines	2004
L-type Ca2+ channel antagonists block voltage-dependent Ca2+ channels in identified leech neurons. Brain research, 2004, Jul-09, Volume: 1013, Issue:2 Topics: Animals; Caffeine; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Gallopamil; Leeches; Membrane Potentials; Neurons; Nifedipine; Phosphodiesterase Inhibitors; Verapamil	2004
Caffeine-induced arrhythmias in murine hearts parallel changes in cellular Ca(2+) homeostasis. American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:4 Topics: Animals; Caffeine; Calcium; Calcium Channel Blockers; Cytosol; Diltiazem; Electric Stimulation; Homeostasis; Immunosuppressive Agents; In Vitro Techniques; Mice; Mice, Inbred Strains; Myocytes, Cardiac; Nifedipine; Perfusion; Phosphodiesterase Inhibitors; Ryanodine Receptor Calcium Release Channel; Tachycardia, Ventricular; Tacrolimus	2005
KCa channel insensitivity to Ca2+ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells. American journal of physiology. Heart and circulatory physiology, 2006, Volume: 291, Issue:3 Topics: Animals; Animals, Newborn; Caffeine; Calcium; Calcium Channel Blockers; Cell Communication; Cell Membrane; Cerebral Arteries; Diltiazem; Electrophysiology; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels, Calcium-Activated; Ryanodine Receptor Calcium Release Channel; Swine	2006
Brazilein-induced contraction of rat arterial smooth muscle involves activation of Ca2+ entry and ROK, ERK pathways. European journal of pharmacology, 2008, Feb-12, Volume: 580, Issue:3 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Aorta, Thoracic; Benzopyrans; Caesalpinia; Caffeine; Calcium; Diltiazem; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; In Vitro Techniques; Indenes; Male; Molecular Structure; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nimodipine; Nitric Oxide Synthase; Phenylephrine; Pinacidil; Potassium Chloride; Rats; Rats, Wistar; rho-Associated Kinases; Signal Transduction; Vasoconstriction	2008
Microbial degradation of pharmaceuticals in estuarine and coastal seawater. Environmental pollution (Barking, Essex : 1987), 2009, Volume: 157, Issue:3 Topics: Absorption; Antipyrine; Bacteria; Biodegradation, Environmental; Caffeine; Carbamazepine; Cotinine; Diltiazem; Ecology; Endocrine Disruptors; Half-Life; New York; Nifedipine; Pharmaceutical Preparations; Seawater; Solubility; Sulfamethoxazole; Trimethoprim; Waste Disposal, Fluid; Water Microbiology; Water Pollutants, Chemical	2009
Participation of L-type calcium channels in ethanol-induced behavioral stimulation and motor incoordination: effects of diltiazem and verapamil. Behavioural brain research, 2010, Jun-19, Volume: 209, Issue:2 Topics: Analysis of Variance; Animals; Ataxia; Behavior, Animal; Caffeine; Calcium Channel Blockers; Calcium Channels, L-Type; Central Nervous System Stimulants; Cocaine; Diltiazem; Dose-Response Relationship, Drug; Ethanol; Male; Mice; Motor Activity; Rotarod Performance Test; Verapamil	2010
Composition, purity and perceived quality of street cocaine in France. The International journal on drug policy, 2010, Volume: 21, Issue:5 Topics: Acetaminophen; Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Data Collection; Diltiazem; Drug Contamination; Drug Users; Female; France; Humans; Illicit Drugs; Lidocaine; Male; Middle Aged; Smoking; Young Adult	2010