Page last updated: 2024-08-23

diltiazem and aspirin

diltiazem has been researched along with aspirin in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (12.35)	18.7374
1990's	35 (43.21)	18.2507
2000's	21 (25.93)	29.6817
2010's	12 (14.81)	24.3611
2020's	3 (3.70)	2.80

Authors

Authors	Studies
Gubernator, K; Kansy, M; Senner, F	1
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Inamasu, M; Morita, T; Sasaki, Y; Shinjo, A	1
Andreotti, F; Davies, GJ; Hackett, DR; Kluft, C; Maseri, A; Prevost, R	1
Lydtin, H; Trenkwalder, P	1
Achmad, TH; Rao, GS	1
Braunwald, E; Hamm, P; Lamas, GA; Pfeffer, MA; Rouleau, JL; Wertheimer, J	1
Rao, GH; Smith, CM; White, JG	1
Waters, D	1
Gibson, RS	1
Therkelsen, K; Toft, E; Vyberg, M	1
Giorgi, LV; Good, TH; Hartzler, GO; Ligon, RW; McCallister, BD; O'Keefe, JH; Webb, DL	1
al-Humayyd, MS	1
Alfonso, F; Casado, J; Fernández-Ortiz, A; Ferrero, J; Hernández, RA; Herrero, C; Iñiguez, A; Macaya, C; Zarco, P	1
Feng, HF; Zhang, YH; Zhao, X	1
Furui, H; Furumichi, T; Hayashi, H; Saito, H; Suzuki, T; Yamada, Y; Yamauchi, K; Yokota, M	1
Brunelli, C; Caponnetto, S; Galassi, AR; Hackett, D; Ianetti, M; Lipkin, D; Maseri, A; Patrono, C; Spallarossa, P; Vejar, M	1
Kienast, J; Verstraete, M	1
Dusleag, J; Eber, B; Fluch, N; Gasser, R; Klein, W; Kronberger-Schaffer, E; Rotman, B; Weinrauch, V	1
Imura, Y; Iwasaki, K; Nishikawa, K; Shibouta, Y; Terashita, Z	1
Conti, CR	1
Nakamura, Y; Sakai, K; Sugimoto, T; Yamazaki, T	1
Altman, R; Dujovne, C; Scazziota, A	1
Corrigan, JJ; Fenster, PE; Ring, ME	1
Kambara, H; Kawai, C; Miwa, K	1
Morishima, Y; Shibano, T; Shibutani, T; Takahashi, M; Tanaka, T; Watanabe, K	1
Buja, LM; Casscells, SW; Goff, DC; Gould, KL	1
Nishiyama, A; Shiga, Y; Shimizu, S; Takatsu, F; Watarai, M	1
Kawashima, A; Koike, H; Nishio, S; Ueno, Y	1
Belgrave, G; Boden, WE; Coltart, DJ; Santoni, JP; Scheldewaert, R; Starkey, IR; Walters, EG; Whitehead, A	1
Karasawa, T; Katoh, M; Odawara, A; Sasaki, Y; Tamura, K	1
Cunningham, D; Fox, K; Hendry, G; Holdright, D; Hubbard, W; Patel, D; Sutton, G; Thomas, R	1
Ashraf, G; Javed, MH; Saeed, SA	1
Altman, R; Budd, SE; Chernoff, SB; Dollar, LE; Zucker, ML	1
Doi, H; Kaburaki, M; Murata, S; Narita, H; Yasoshima, A	1
Castro, P; Corbalán, R; Kunstmann, S; Vergara, I	1
Beaughard, M; Brasset, M; John, G; Massingham, R	1
Blackshear, JL; Hammill, SC; Kopecky, SL; Litin, SC; Safford, RE	1
Katoh, M; Kikkawa, K; Odawara, A; Sasaki, Y; Shimazaki, T; Toryu, H	1
Lim, YT; Ng, WL; Sim, EK; Yeo, TC	1
Gunnar, RM; Wilber, DJ	1
Gilani, AH; Rashid, F; Saeed, SA; Shah, BH	1
Bove, AA; Davis, MJ; Sorrell, VL	1
Evéquoz, D	1
Carrier, M; Daly, P; Davies, R; Gudas, V; Kostuk, W; Latter, D; Rivard, M; Sullivan, J; Teo, K; White, M	1
Ahn, YK; Bae, Y; Cho, JG; Cho, JH; Jeong, MH; Kang, JC; Kang, KT; Kim, KH; Kim, NH; Kim, SH; Lee, SH; Park, JC; Rhew, JY	1
Doi, H; Karasawa, T; Katoh, M; Odawara, A	1
Gadzhiev, AN	1
Cieśliński, A; Grajek, S; Grygier, M; Mularek-Kubzdela, T; Seniuk, W	1
Ashby, DT; Conditt, G; Dangas, G; Hirose, M	1
Chen, J; Dai, H; Qiu, Y; Tao, Q; Zhang, F; Zheng, L; Zhu, J	1
Frimerman, A; Lev-Ran, O; Locker, C; Mohr, R; Shaham, Y; Shapira, I; Uretzky, G	1
De Jonghe, B; Fangio, P; Lachérade, JC; Outin, H; Terville, JP	1
de Araújo, EC; de Sousa, LN; Santos, Lde M	1
Chi, J; Guo, H; Yang, B	1
Dobarro, D; Gómez-Rubín, MC; Moreno, R; Sánchez-Recalde, A	1
Chen, SJ; Hwang, BT; Lee, PC; Tsai, MC; Wang, AC	1
Tang, SW; Wang, HT; Wu, XL; Wu, YL; Zhang, HX; Zhang, YF; Zhu, HM	1
Dönmez, O; Durmaz, O	1
Eckel, RH	1
Lahmers, SM; Reina Doreste, Y; Stern, JA	1
Jain, A; Murthy, A; Murthy, AM; Tan, H	1
Huang, Q; Pei, A; Sui, XQ; Wang, SS; Wang, WT	1
Ge, T; Song, EJ; Tang, S; Wang, J; Zhou, W; Zhu, Z	1
Guo, Y; Huang, S; Liu, J; Shang, X; Wang, X; Yao, B; Zhang, Y	1

Reviews

7 review(s) available for diltiazem and aspirin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Management of acute non-Q-wave myocardial infarction. The role of prophylactic diltiazem therapy and indications for predischarge coronary arteriography. Drugs, 1991, Volume: 42 Suppl 2 Topics: Adrenergic beta-Antagonists; Aspirin; Calcium Channel Blockers; Coronary Angiography; Diltiazem; Electrocardiography; Humans; Myocardial Infarction; Recurrence	1991
Pharmacology of the interaction between platelets and vessel wall. Clinics in haematology, 1986, Volume: 15, Issue:2 Topics: Animals; Aspirin; Blood Platelets; Blood Vessels; Dextrans; Diltiazem; Dipyridamole; Epoprostenol; Humans; Imidazoles; Ketanserin; Piperidines; Pyrazoles; Pyrazolones; Sulfinpyrazone; Sulfonamides; Thiophenes; Ticlopidine	1986
Large vessel coronary vasospasm: diagnosis, natural history and treatment. The American journal of cardiology, 1985, Jan-25, Volume: 55, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aspirin; Coronary Artery Bypass; Coronary Disease; Coronary Vasospasm; Diltiazem; Electrocardiography; Epoprostenol; Female; Fibrinolytic Agents; Humans; Isosorbide Dinitrate; Male; Nifedipine; Nitrates; Prazosin; Verapamil	1985
Management of atrial fibrillation in adults: prevention of thromboembolism and symptomatic treatment. Mayo Clinic proceedings, 1996, Volume: 71, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Age Factors; Aged; Anti-Arrhythmia Agents; Aspirin; Atrial Fibrillation; Catheter Ablation; Cerebrovascular Disorders; Diabetes Complications; Digoxin; Diltiazem; Embolism; Humans; Hypertension; Thromboembolism; Verapamil; Warfarin	1996
Current knowledge and significance of coronary artery ectasia: a chronologic review of the literature, recommendations for treatment, possible etiologies, and future considerations. Clinical cardiology, 1998, Volume: 21, Issue:3 Topics: Anticoagulants; Aspirin; Calcium Channel Blockers; Coronary Disease; Coronary Vessels; Dilatation, Pathologic; Diltiazem; Humans; Incidence; Nitric Oxide; Platelet Aggregation Inhibitors; Warfarin	1998
Comparison of bilateral thoracic artery grafting with percutaneous coronary interventions in diabetic patients. The Annals of thoracic surgery, 2004, Volume: 78, Issue:2 Topics: Abciximab; Aged; Angioplasty, Balloon; Angioplasty, Balloon, Coronary; Antibodies, Monoclonal; Aspirin; Combined Modality Therapy; Coronary Artery Bypass; Coronary Disease; Diabetes Complications; Diltiazem; Eptifibatide; Female; Humans; Immunoglobulin Fab Fragments; Isosorbide Dinitrate; Life Tables; Male; Middle Aged; Peptides; Platelet Aggregation Inhibitors; Recurrence; Retrospective Studies; Stents; Survival Analysis; Thoracic Arteries; Ticlopidine; Treatment Outcome; Vascular Patency	2004

Trials

15 trial(s) available for diltiazem and aspirin

Article	Year
Prolonged coagulation instability is associated with a higher-dose regimen of tissue-type plasminogen activator in patients with acute myocardial infarction. Annals of the New York Academy of Sciences, 1992, Dec-04, Volume: 667 Topics: Antithrombin III; Aspirin; Biomarkers; Diltiazem; Drug Administration Schedule; Drug Monitoring; Female; Fibrinolysis; Heparin; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Peptide Hydrolases; Recombinant Proteins; Tissue Plasminogen Activator	1992
Do the results of randomized clinical trials of cardiovascular drugs influence medical practice? The SAVE Investigators. The New England journal of medicine, 1992, Jul-23, Volume: 327, Issue:4 Topics: Adult; Aged; Aspirin; Calcium Channel Blockers; Captopril; Cardiomegaly; Cardiovascular Agents; Diltiazem; Drug Utilization; Female; Humans; Male; Middle Aged; Myocardial Infarction; Practice Patterns, Physicians'; Randomized Controlled Trials as Topic; Survival Rate; Time Factors; United States	1992
Management of acute non-Q-wave myocardial infarction. The role of prophylactic diltiazem therapy and indications for predischarge coronary arteriography. Drugs, 1991, Volume: 42 Suppl 2 Topics: Adrenergic beta-Antagonists; Aspirin; Calcium Channel Blockers; Coronary Angiography; Diltiazem; Electrocardiography; Humans; Myocardial Infarction; Recurrence	1991
Effects of diltiazem on complications and restenosis after coronary angioplasty. The American journal of cardiology, 1991, Feb-15, Volume: 67, Issue:5 Topics: Angioplasty, Balloon, Coronary; Aspirin; Constriction, Pathologic; Coronary Angiography; Coronary Disease; Diltiazem; Dipyridamole; Double-Blind Method; Female; Follow-Up Studies; Humans; Incidence; Male; Recurrence	1991
[Drug modulation of thromboxane A2/prostacyclin balance and lipid peroxidation in patients with coronary artery disease]. Zhonghua nei ke za zhi, 1990, Volume: 29, Issue:8 Topics: Aged; Aspirin; Coronary Disease; Diltiazem; Epoprostenol; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Superoxide Dismutase; Thromboxane A2	1990
Comparison of low-dose aspirin and coronary vasodilators in acute unstable angina. Circulation, 1990, Volume: 81, Issue:1 Suppl Topics: Angina Pectoris; Angina, Unstable; Aspirin; Diltiazem; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Isosorbide Dinitrate; Male; Middle Aged; Platelet Aggregation; Randomized Controlled Trials as Topic; Thromboxane A2; Thromboxane B2	1990
[Do thrombocyte aggregation inhibitors modify silent episodes of unstable angina pectoris in combined anti-angina therapy?]. Zeitschrift fur Kardiologie, 1989, Volume: 78 Suppl 2 Topics: Aged; Angina Pectoris; Angina, Unstable; Aspirin; Coronary Circulation; Diltiazem; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Humans; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Platelet Aggregation Inhibitors; Randomized Controlled Trials as Topic	1989
Design of a placebo-controlled clinical trial of long-acting diltiazem and aspirin versus aspirin alone in patients receiving thrombolysis with a first acute myocardial infarction. Incomplete Infarction Trial of European Research Collaborators Evaluating The American journal of cardiology, 1995, Jun-01, Volume: 75, Issue:16 Topics: Adolescent; Adult; Aged; Aspirin; Delayed-Action Preparations; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Europe; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prognosis; Prospective Studies; Research Design; Thrombolytic Therapy	1995
Comparison of the effect of heparin and aspirin versus aspirin alone on transient myocardial ischemia and in-hospital prognosis in patients with unstable angina. Journal of the American College of Cardiology, 1994, Volume: 24, Issue:1 Topics: Adult; Aged; Angina, Unstable; Aspirin; Chi-Square Distribution; Diltiazem; Drug Therapy, Combination; Electrocardiography; Female; Heparin; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Nitrates; Prognosis; Single-Blind Method; United Kingdom	1994
Effect of diltiazem and low-dose aspirin on platelet aggregation and ATP release induced by paired agonists. Thrombosis and haemostasis, 1993, Aug-02, Volume: 70, Issue:2 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adult; Arachidonic Acid; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Drug Synergism; Epinephrine; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors	1993
[Diltiazem versus intravenous nitroglycerin in the treatment of unstable angina pectoris. A randomized study]. Revista medica de Chile, 1995, Volume: 123, Issue:7 Topics: Aged; Analysis of Variance; Angina, Unstable; Anticoagulants; Aspirin; Blood Pressure; Cardiovascular Agents; Diltiazem; Female; Heparin; Humans; Injections, Intravenous; Male; Middle Aged; Nitroglycerin; Platelet Aggregation Inhibitors; Prospective Studies; Vasodilator Agents	1995
[Comparison of invasive and drug therapy approaches in non-transmural acute infarct]. Praxis, 1999, Jan-14, Volume: 88, Issue:3 Topics: Angioplasty, Balloon, Coronary; Aspirin; Coronary Artery Bypass; Diltiazem; Humans; Myocardial Infarction; Prospective Studies; Survival Rate; Treatment Outcome	1999
[Dilzem-retard efficiency in patients with ischemic heart disease and heart failure]. Klinicheskaia meditsina, 2002, Volume: 80, Issue:6 Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium Channel Blockers; Delayed-Action Preparations; Diltiazem; Drug Therapy, Combination; Female; Heart Failure; Humans; Hypertension; Male; Myocardial Ischemia; Treatment Outcome	2002
Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty. Postgraduate medical journal, 2003, Volume: 79, Issue:935 Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Calcium; Calcium Channel Blockers; Coronary Thrombosis; Cytosol; Diltiazem; Drug Therapy, Combination; Female; Humans; Male; P-Selectin; Platelet Activation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thromboxane B2; Ticlopidine	2003
Cardiovascular magnetic resonance image analysis and mechanism study for the changes after treatments for primary microvascular angina pectoris. Medicine, 2021, May-28, Volume: 100, Issue:21 Topics: Adolescent; Adult; Aged; Aspirin; Cardiovascular System; Coronary Angiography; Diltiazem; Drug Therapy, Combination; Electrocardiography; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Magnetic Resonance Imaging; Male; Microvascular Angina; Middle Aged; Nicorandil; Nitroglycerin; Randomized Controlled Trials as Topic; Treatment Outcome; Vasodilator Agents; Young Adult	2021

Other Studies

60 other study(ies) available for diltiazem and aspirin

Article	Year
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. Journal of medicinal chemistry, 1998, Mar-26, Volume: 41, Issue:7 Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet	1998
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
In vitro effect of the coronary vasodilator diltiazem on human and rabbit platelets. Thrombosis research, 1978, Volume: 13, Issue:6 Topics: Adenosine Diphosphate; Animals; Arachidonic Acids; Aspirin; Benzazepines; Blood Platelets; Calcium; Collagen; Diltiazem; Egtazic Acid; Humans; Indomethacin; Male; Platelet Aggregation; Rabbits; Vasodilator Agents	1978
[Therapy of coronary disease]. Deutsche medizinische Wochenschrift (1946), 1992, Jan-03, Volume: 117, Issue:1 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dipyridamole; Drug Therapy, Combination; Humans; Isosorbide Dinitrate; Metoprolol; Nitrates; Smoking; Verapamil	1992
Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers. Biochemical and biophysical research communications, 1992, Dec-15, Volume: 189, Issue:2 Topics: Aspirin; Calcium Channel Blockers; Chemotaxis, Leukocyte; Diltiazem; Dose-Response Relationship, Drug; Endothelins; Humans; In Vitro Techniques; Indomethacin; Kinetics; Monocytes; Neomycin; Nifedipine; Probucol; Thioctic Acid; Verapamil	1992
Influence of calcium antagonists on thrombin-induced calcium mobilization and platelet-vessel wall interactions. Biochemical medicine and metabolic biology, 1992, Volume: 47, Issue:3 Topics: Aspirin; Blood Platelets; Calcium; Calcium Channel Blockers; Cytosol; Diltiazem; Endothelium, Vascular; Humans; In Vitro Techniques; Nifedipine; Thrombin; Verapamil	1992
Myocardial infarction in patients with previous bypass surgery. Cardiovascular clinics, 1991, Volume: 21, Issue:2 Topics: Adrenergic beta-Antagonists; Aspirin; Coronary Angiography; Coronary Disease; Diltiazem; Electrocardiography; Follow-Up Studies; Graft Occlusion, Vascular; Humans; Myocardial Infarction; Platelet Aggregation Inhibitors; Postoperative Complications; Risk Factors; Survival Rate	1991
Diltiazem-induced granulomatous hepatitis. Histopathology, 1991, Volume: 18, Issue:5 Topics: Aged; Aspirin; Atenolol; Chemical and Drug Induced Liver Injury; Diltiazem; Female; Granuloma; Humans; Liver; Liver Function Tests; Myocardial Infarction	1991
Effect of diltiazem, nifedipine and verapamil on the antinociceptive action of acetylsalicylic acid in mice. General pharmacology, 1991, Volume: 22, Issue:1 Topics: Analgesics; Animals; Aspirin; Benzoquinones; Diltiazem; Drug Interactions; Male; Mice; Nifedipine; Pain; Reaction Time; Verapamil	1991
[The results of percutaneous transluminal coronary angioplasty in lesions with thrombi]. Revista espanola de cardiologia, 1991, Volume: 44, Issue:4 Topics: Angioplasty, Balloon, Coronary; Aspirin; Chi-Square Distribution; Combined Modality Therapy; Coronary Angiography; Coronary Thrombosis; Diltiazem; Evaluation Studies as Topic; Humans; Myocardial Infarction; Prospective Studies	1991
Inhibitory effects of endothelial cells and calcium channel blockers on platelet aggregation. Japanese heart journal, 1990, Volume: 31, Issue:2 Topics: 6-Ketoprostaglandin F1 alpha; Adenosine Diphosphate; Aspirin; Blood Platelets; Bone Marrow Cells; Calcium Channel Blockers; Collagen; Diltiazem; Endothelium, Vascular; Epoprostenol; Fibroblasts; Humans; Nicardipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombin; Thromboxane A2; Verapamil	1990
Non-Q-wave myocardial infarction. Lancet (London, England), 1989, Oct-14, Volume: 2, Issue:8668 Topics: Aspirin; Diltiazem; Electrocardiography; Humans; Myocardial Infarction; Prognosis; Thrombolytic Therapy	1989
Endothelin-induced sudden death and the possible involvement of platelet activating factor (PAF). Life sciences, 1989, Volume: 45, Issue:20 Topics: Animals; Aspirin; Azepines; Blood Pressure; Death, Sudden; Dexamethasone; Diltiazem; Electrocardiography; Endothelins; Guinea Pigs; Hypertension; Hypotension; Male; Mice; Mice, Inbred ICR; Peptides; Platelet Activating Factor; Pyridinium Compounds; Rats; Rats, Inbred Strains; Triazines; Triazoles	1989
Protective effects of the antianginal agent nicorandil on arachidonate-induced sudden death in rats: comparison with several antianginal agents and cyclooxygenase inhibitors. Japanese journal of pharmacology, 1985, Volume: 37, Issue:1 Topics: Angina Pectoris; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Cyclooxygenase Inhibitors; Death, Sudden; Diltiazem; Indomethacin; Male; Mice; Niacinamide; Nicorandil; Nitroglycerin; Rats; Rats, Inbred Strains; Vasodilator Agents	1985
Diltiazem potentiates the inhibitory effect of aspirin on platelet aggregation. Clinical pharmacology and therapeutics, 1988, Volume: 44, Issue:3 Topics: Arachidonic Acids; Aspirin; Diltiazem; Drug Synergism; Female; Humans; Male; Platelet Activating Factor; Platelet Aggregation; Time Factors	1988
Effects of oral diltiazem on platelet function: alone and in combination with "low dose" aspirin. Thrombosis research, 1986, Nov-01, Volume: 44, Issue:3 Topics: Adenosine Diphosphate; Adenosine Triphosphate; Administration, Oral; Aspirin; Bleeding Time; Blood Platelets; Diltiazem; Epinephrine; Humans; Male; Platelet Aggregation; Thromboxane A2	1986
Effect of aspirin in large doses on attacks of variant angina. American heart journal, 1983, Volume: 105, Issue:2 Topics: Adult; Aged; Angina Pectoris, Variant; Aspirin; Coronary Vasospasm; Diltiazem; Electrocardiography; Humans; Male; Middle Aged	1983
Failure of aspirin and diltiazem to prevent the formation of acute coronary thrombi in dogs. Methods and findings in experimental and clinical pharmacology, 1995, Volume: 17, Issue:4 Topics: Animals; Aspirin; Blood Pressure; Cardiovascular Agents; Coronary Circulation; Coronary Thrombosis; Diltiazem; Dogs; Female; Heart Rate; Male; Platelet Aggregation Inhibitors	1995
Non-invasive management of coronary artery disease. Report of a meeting at the University of Texas Medical School at Houston. Lancet (London, England), 1995, Sep-16, Volume: 346, Issue:8977 Topics: Aged; Anticholesteremic Agents; Aspirin; beta Carotene; Carotenoids; Cholesterol, Dietary; Coronary Disease; Diet, Fat-Restricted; Diltiazem; Drug Therapy, Combination; Enalapril; Humans; Lovastatin; Male; Simvastatin; Tomography, Emission-Computed; Vitamins	1995
Long-term follow-up of coronary narrowing with spasm. International journal of cardiology, 1994, Volume: 47, Issue:1 Suppl Topics: Angina Pectoris, Variant; Aspirin; Coronary Angiography; Coronary Artery Disease; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Electrocardiography; Ergonovine; Follow-Up Studies; Humans; Isosorbide Dinitrate; Male; Middle Aged; Nifedipine	1994
Effect of beraprost sodium, a stable prostacyclin analogue, on pulmonary thromboembolism in mice. Thrombosis research, 1995, Jan-15, Volume: 77, Issue:2 Topics: Administration, Oral; Alprostadil; Animals; Aspirin; Bridged Bicyclo Compounds; Collagen; Diltiazem; Drug Evaluation, Preclinical; Epinephrine; Epoprostenol; Fatty Acids, Monounsaturated; Fibrinolytic Agents; Heparin; Hydralazine; Injections, Intravenous; Isosorbide Dinitrate; Male; Mice; Nifedipine; Nitroprusside; Platelet Aggregation Inhibitors; Pulmonary Embolism; Superoxide Dismutase; Vasodilator Agents	1995
Inhibitory effect of clentiazem (TA-3090) on platelet aggregation--alone and in combination with aspirin or ticlopidine. Thrombosis research, 1994, Jul-15, Volume: 75, Issue:2 Topics: Animals; Aspirin; Calcium Channel Blockers; Diltiazem; Drug Synergism; Drug Therapy, Combination; Humans; Male; Molecular Structure; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Ticlopidine	1994
Modulation of cyclic AMP-dependent protein kinase activity by drugs affecting human platelet aggregation. Biochemical Society transactions, 1993, Volume: 21, Issue:4 Topics: Aspirin; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Diltiazem; Humans; Kinetics; Masoprocol; Platelet Aggregation; Theophylline; Verapamil	1993
Antithrombotic effect of TA-993, a novel 1,5-benzothiazepine derivative, in conscious rats. Japanese journal of pharmacology, 1995, Volume: 68, Issue:4 Topics: Administration, Oral; Animals; Antithrombins; Aspirin; Diltiazem; Dose-Response Relationship, Drug; Embolism; Male; Microscopy, Electron; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Thrombosis; Ticlopidine; Time Factors	1995
Failure of calcium channel blockade to reduce platelet-mediated cyclic flow variations in dogs with coronary stenosis and endothelial injury. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:4 Topics: Animals; Aspirin; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Disease Models, Animal; Dogs; Endothelium, Vascular; Female; Heart Block; Infusions, Intravenous; Ketanserin; Male; Nifedipine; Platelet Aggregation; Platelet Aggregation Inhibitors; Thrombosis; Vasodilator Agents; Verapamil	1995
Inhibitory effects of TA-993, a new 1,5-benzothiazepine derivative, on platelet aggregation. Circulation research, 1996, Volume: 78, Issue:4 Topics: Animals; Aspirin; Basilar Artery; Calcium; Diltiazem; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Fibrinolytic Agents; Humans; Male; Mice; Platelet Aggregation; Platelet Aggregation Inhibitors; Rats; Rats, Sprague-Dawley; Ticlopidine; Vasoconstriction	1996
Surgery for left main spasm. Is it indicated? International journal of cardiology, 1996, Volume: 54, Issue:3 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiac Surgical Procedures; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Felodipine; Humans; Isosorbide Dinitrate; Male; Nitroglycerin; Vasodilator Agents	1996
Therapeutic options in atrial flutter and fibrillation. Hospital practice (1995), 1997, May-15, Volume: 32, Issue:5 Topics: Aged; Algorithms; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Diagnosis, Differential; Diltiazem; Electric Countershock; Electrocardiography; Humans; Male; Recurrence	1997
Dopamine potentiation of calcium ionophore, A-23187-induced platelet aggregation. Advances in experimental medicine and biology, 1997, Volume: 407 Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaloids; Androstadienes; Aspirin; Benzophenanthridines; Calcimycin; Calcium; Chlorpromazine; Diltiazem; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; GTP-Binding Proteins; Haloperidol; Homovanillic Acid; Humans; Indomethacin; Ion Transport; Ionophores; Phenanthridines; Phentolamine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Dopamine; Serotonin; Signal Transduction; Verapamil; Wortmannin	1997
The Canadian Study of Cardiac Transplantation. Atherosclerosis. Investigators of the CASCADE Study. The Canadian journal of cardiology, 1999, Volume: 15, Issue:12 Topics: Adult; Antihypertensive Agents; Arteriosclerosis; Aspirin; Cardiovascular Agents; Cyclosporine; Cytomegalovirus Infections; Diltiazem; Female; Follow-Up Studies; Heart Transplantation; Humans; Male; Middle Aged; Myocardial Ischemia; Postoperative Care; Postoperative Complications	1999
Successful management of intractable coronary spasm with a coronary stent. Japanese circulation journal, 2000, Volume: 64, Issue:11 Topics: Adult; Amlodipine; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; Coronary Artery Disease; Coronary Vasospasm; Diltiazem; Doxazosin; Drug Resistance; Drug Therapy, Combination; Ergonovine; Humans; Isosorbide Dinitrate; Male; Myocardial Infarction; Nicorandil; Nitrates; Pyridines; Stents; Ticlopidine; Ventricular Fibrillation	2000
Effects of the antiplatelet agent TA-993 and its metabolite MB3 on the hemorheological properties of rat and human erythrocytes. Thrombosis research, 2001, Oct-15, Volume: 104, Issue:2 Topics: Animals; Aspirin; Blood Viscosity; Diltiazem; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Hemorheology; Humans; Phospholipids; Platelet Aggregation Inhibitors; Rats; Ticlopidine	2001
Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study. Journal of internal medicine, 2002, Volume: 252, Issue:4 Topics: Amiodarone; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; Diltiazem; Electrocardiography; Female; Follow-Up Studies; Heart Arrest; Heart Block; Humans; Male; Middle Aged; Nitrates; Nitroglycerin; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Spasm; Time Factors; Vasodilator Agents; Ventricular Fibrillation	2002
Coronary artery spasm associated with a moderately severe atherosclerotic stenosis in the proximal LAD. The Journal of invasive cardiology, 2002, Volume: 14, Issue:12 Topics: Adult; Aspirin; Atorvastatin; Cardiac Catheterization; Coronary Angiography; Coronary Artery Disease; Coronary Stenosis; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heptanoic Acids; Humans; Isosorbide; Pyrroles; Sensitivity and Specificity; Severity of Illness Index; Treatment Outcome; Ultrasonography, Interventional	2002
Coronary spasm in a 59-yr-old woman with hyperventilation. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2004, Volume: 51, Issue:8 Topics: Alkalosis, Respiratory; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antihypertensive Agents; Aspirin; Cardiac Catheterization; Clopidogrel; Coronary Artery Disease; Coronary Vasospasm; Diagnosis, Differential; Diltiazem; Electrocardiography; Female; Heparin; Humans; Hyperventilation; Hyponatremia; Middle Aged; Platelet Aggregation Inhibitors; Schizophrenia; Ticlopidine; Water Intoxication	2004
Multi-arterial myocardial bridge: uncommon clinical and anatomical presentations. Arquivos brasileiros de cardiologia, 2007, Volume: 88, Issue:4 Topics: Adrenergic beta-Antagonists; Adult; Aspirin; Calcium Channel Blockers; Coronary Angiography; Coronary Vessel Anomalies; Diltiazem; Electrocardiography; Humans; Male; Metoprolol	2007
Acute myocardial infarction associated with myocardial bridging: a case report. Acta cardiologica, 2007, Volume: 62, Issue:5 Topics: Acute Disease; Adrenergic beta-Antagonists; Adult; Aspirin; Coronary Angiography; Coronary Thrombosis; Diltiazem; Female; Humans; Myocardial Bridging; Myocardial Infarction; Risk Factors; Tomography, Spiral Computed	2007
[Severe vasoespasm during coronary angiograms in a patient with Prinzmetal syndrome]. Medicina clinica, 2008, Mar-08, Volume: 130, Issue:8 Topics: Administration, Cutaneous; Administration, Oral; Angina Pectoris, Variant; Aspirin; Cardiovascular Agents; Chest Pain; Coronary Angiography; Coronary Vasospasm; Diltiazem; Drug Therapy, Combination; Electrocardiography; Follow-Up Studies; Humans; Male; Middle Aged; Nitrates; Platelet Aggregation Inhibitors; Time Factors	2008
Variant angina in an adolescent coexisting with intermittent Wolff-Parkinson-White syndrome. The American journal of emergency medicine, 2008, Volume: 26, Issue:8 Topics: Adolescent; Angina Pectoris, Variant; Aspirin; Calcium Channel Blockers; Coronary Angiography; Diltiazem; Electrocardiography; Humans; Male; Platelet Aggregation Inhibitors; Wolff-Parkinson-White Syndrome	2008
[Protective effect of Tongxinluo Ultramicro-pulverization on experimental myocardial infarction of rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2008, Volume: 33, Issue:15 Topics: Adenosine Diphosphate; Animals; Aspirin; Diltiazem; Drugs, Chinese Herbal; Female; Male; Medicine, Chinese Traditional; Myocardial Infarction; Platelet Aggregation; Random Allocation; Rats; Rats, Sprague-Dawley; Tetrazolium Salts	2008
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. Pediatric nephrology (Berlin, Germany), 2010, Volume: 25, Issue:7 Topics: Administration, Oral; Antiphospholipid Syndrome; Aspirin; Calcinosis; Child; Cyclosporine; Dermatologic Agents; Diltiazem; Drug Therapy, Combination; Enoxaparin; Fibrinolytic Agents; Glomerulonephritis, Membranoproliferative; Glucocorticoids; Humans; Lupus Erythematosus, Systemic; Male; Skin Ulcer; Treatment Outcome	2010
Approach to the patient who is intolerant of statin therapy. The Journal of clinical endocrinology and metabolism, 2010, Volume: 95, Issue:5 Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aspirin; Atorvastatin; Coronary Disease; Diltiazem; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Middle Aged; Pyrroles; Simvastatin	2010
ECG of the month. Multiple episodes of collapse in a cat. Journal of the American Veterinary Medical Association, 2013, Apr-01, Volume: 242, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Aspirin; Atenolol; Calcium Channel Blockers; Cat Diseases; Cats; Diltiazem; Electrocardiography; Male; Platelet Aggregation Inhibitors	2013
A not so benign atrial flutter: spontaneous 1:1 conduction of atrial flutter. BMJ case reports, 2013, Apr-22, Volume: 2013 Topics: Adrenergic beta-Antagonists; Aspirin; Atrial Flutter; Calcium Channel Blockers; Catheter Ablation; Diagnosis, Differential; Diltiazem; Drug Therapy, Combination; Echocardiography; Electrocardiography; Humans; Male; Middle Aged	2013
A rare cause of abdominal pain managed unconventionally: acute renal infarction caused by atrial fibrillation: a case report. Journal of medical case reports, 2022, Oct-19, Volume: 16, Issue:1 Topics: Abdominal Pain; Aged; Anticoagulants; Aspirin; Atrial Fibrillation; Clopidogrel; Diltiazem; Humans; Infarction; Male; Nitroglycerin; Platelet Aggregation Inhibitors; Thromboembolism; Thrombosis; Warfarin	2022
Design and Construction of Carboxylesterase 2c Gene Knockout Rats by CRISPR/Cas9. Current drug metabolism, 2023, Volume: 24, Issue:3 Topics: Animals; Aspirin; CRISPR-Cas Systems; Diltiazem; Gene Knockout Techniques; Humans; Liver; Rats	2023