Page last updated: 2024-08-23

diltiazem and antipyrine

diltiazem has been researched along with antipyrine in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (18.52)	18.7374
1990's	4 (14.81)	18.2507
2000's	11 (40.74)	29.6817
2010's	6 (22.22)	24.3611
2020's	1 (3.70)	2.80

Authors

Authors	Studies
Coassolo, P; Lavé, T; Schneider, G	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Caron, G; Ermondi, G	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Ebihara, A; Fujimura, A; Harada, K; Ohashi, K; Sakamoto, K; Sudo, T; Tanaka, E; Tateishi, T	1
Akita, H; Hamada, K; Iida, S; Kobayashi, S; Sakai, H; Tanaka, E; Uchida, E; Yasuhara, H	1
Klockowski, PM; Lener, ME; Rocci, ML; Sirgo, MA	1
Bottorff, MB; Hoon, TJ; Kazierad, DJ; Lalonde, RL; Mirvis, DM; Tsiu, SJ	1
Fruncillo, RA; Lener, ME; Rocci, ML; Sirgo, MA; Vlasses, PH	1
Abernethy, DR; Carrum, G; Dickinson, TH; Egan, JM	1
Abernethy, DR; Carrum, G; Egan, JM	1
Bauer, LA; Davis, R; Greene, L; Horn, JR; Opheim, K; Stenwall, M	1
Benotti, MJ; Brownawell, BJ	1
Chang, H; Chen, C; Du, H; Guan, C; Li, C; Qiu, L; Wang, S; Wang, T; Wu, Y; Zhang, L; Zhang, S; Zhou, H	1

Trials

4 trial(s) available for diltiazem and antipyrine

Article	Year
Comparative evaluation of the effects of isradipine and diltiazem on antipyrine and indocyanine green clearances in elderly volunteers. Clinical pharmacology and therapeutics, 1990, Volume: 48, Issue:4 Topics: Aged; Aged, 80 and over; Antipyrine; Biomarkers; Calcium Channel Blockers; Diltiazem; Humans; Indocyanine Green; Isradipine; Liver; Liver Circulation; Oxidation-Reduction; Pyridines	1990
The effects of encainide versus diltiazem on the oxidative metabolic pathways of antipyrine. Pharmacotherapy, 1989, Volume: 9, Issue:5 Topics: Adult; Anilides; Anti-Arrhythmia Agents; Antipyrine; Diltiazem; Drug Interactions; Encainide; Humans; Male; Metabolic Clearance Rate; Oxidation-Reduction; Random Allocation	1989
Comparative evaluation of the effects of labetalol, verapamil and diltiazem on antipyrine and indocyanine green clearances. Journal of clinical pharmacology, 1989, Volume: 29, Issue:10 Topics: Adult; Antipyrine; Diltiazem; Half-Life; Humans; Indocyanine Green; Labetalol; Male; Random Allocation; Verapamil	1989
Changes in antipyrine and indocyanine green kinetics during nifedipine, verapamil, and diltiazem therapy. Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:2 Topics: Adult; Antipyrine; Benzazepines; Biological Availability; Diltiazem; Drug Interactions; Female; Humans; Indocyanine Green; Kinetics; Liver; Male; Metabolic Clearance Rate; Nifedipine; Random Allocation; Verapamil	1986

Other Studies

23 other study(ies) available for diltiazem and antipyrine

Article	Year
Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques. Journal of medicinal chemistry, 1999, Dec-16, Volume: 42, Issue:25 Topics: Animals; Biological Availability; Dogs; Humans; Least-Squares Analysis; Liver; Multivariate Analysis; Neural Networks, Computer; Pharmacokinetics; Rats	1999
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The effect of diltiazem on hepatic drug oxidation assessed by antipyrine and trimethadione. Journal of clinical pharmacology, 1991, Volume: 31, Issue:12 Topics: Adult; Antipyrine; Diltiazem; Half-Life; Humans; Liver; Male; Metabolic Clearance Rate; Premedication; Trimethadione	1991
The effects of diltiazem on hepatic drug metabolizing enzymes in man using antipyrine, trimethadione and debrisoquine as model substrates. British journal of clinical pharmacology, 1991, Volume: 31, Issue:3 Topics: Adult; Antipyrine; Debrisoquin; Diltiazem; Dimethadione; Drug Interactions; Half-Life; Humans; Liver; Male; Mixed Function Oxygenases; Trimethadione	1991
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:3 Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline; Verapamil	1988
Diltiazem treatment impairs hepatic drug oxidation: studies of antipyrine. Clinical pharmacology and therapeutics, 1986, Volume: 40, Issue:2 Topics: Administration, Oral; Adult; Antipyrine; Benzazepines; Diltiazem; Drug Interactions; Female; Humans; Kinetics; Liver; Male; Middle Aged	1986
Microbial degradation of pharmaceuticals in estuarine and coastal seawater. Environmental pollution (Barking, Essex : 1987), 2009, Volume: 157, Issue:3 Topics: Absorption; Antipyrine; Bacteria; Biodegradation, Environmental; Caffeine; Carbamazepine; Cotinine; Diltiazem; Ecology; Endocrine Disruptors; Half-Life; New York; Nifedipine; Pharmaceutical Preparations; Seawater; Solubility; Sulfamethoxazole; Trimethoprim; Waste Disposal, Fluid; Water Microbiology; Water Pollutants, Chemical	2009
Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats. Pharmacology research & perspectives, 2021, Volume: 9, Issue:5 Topics: Animals; Antipyrine; Atenolol; Carbamazepine; Cell Membrane; Digoxin; Diltiazem; Diphenhydramine; Drug Elimination Routes; Gabapentin; Lamotrigine; Liver; Memantine; Membrane Transport Proteins; Microdialysis; Muscle, Skeletal; Ofloxacin; Pharmaceutical Preparations; Propranolol; Pyrilamine; Quinidine; Rats; Terfenadine	2021