Page last updated: 2024-08-23

diltiazem and acetaminophen

diltiazem has been researched along with acetaminophen in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	6 (17.14)	18.2507
2000's	18 (51.43)	29.6817
2010's	11 (31.43)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Akamatsu, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Deakin, CD; Fagan, EA; Gove, CD; Tredger, JM; Williams, R	1
du Souich, P; Kobusch, AB	1
Esteban, A; Graells, ML; Mayol, MJ; Pérez-Mateo, M; Satorres, J	1
Hamrick, ME; Harris, SR	1
Dimova, S; Koleva, M; Rangelova, D; Stoythchev, T	1
Dimova, S; Koleva, M	1
Cui, JB; Jiang, XG; Lu, X; Qiu, L; Xi, NZ	1
Kagayama, A; Naritomi, Y; Sugiyama, Y; Terashita, S	1
Generoso, M; Kanis, LA; Meier, MM; Pires, AT; Soldi, V	1
Rahman, NU; Woei, WJ; Yuen, KH	1
Choi, K; Jung, J; Kim, PG; Kim, Y; Park, J; Park, S	1
Dinarvand, R; Khorram, M; Vasheghani-Farahani, E	1
Carlin, B; Leclercq, B; Muschert, S; Siepmann, F; Siepmann, J	1
Cadet-Taïrou, A; Evrard, I; Legleye, S	1

Reviews

1 review(s) available for diltiazem and acetaminophen

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

34 other study(ies) available for diltiazem and acetaminophen

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
QSAR study on permeability of hydrophobic compounds with artificial membranes. Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11 Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship	2007
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Importance of physicochemical properties for the design of new pesticides. Journal of agricultural and food chemistry, 2011, Apr-13, Volume: 59, Issue:7 Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Delayed calcium channel blockade with diltiazem reduces paracetamol hepatotoxicity in mice. Human & experimental toxicology, 1991, Volume: 10, Issue:2 Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Diltiazem; Drug Administration Schedule; Liver Diseases; Liver Regeneration; Male; Mice; Nifedipine	1991
Effect of diltiazem on acetaminophen and phalloidine hepatotoxicity. Research communications in chemical pathology and pharmacology, 1990, Volume: 68, Issue:2 Topics: Acetaminophen; Alanine Transaminase; Analysis of Variance; Animals; Calcium; Cell Survival; Diltiazem; Liver; Male; Mice; Oligopeptides; Phalloidine; Time Factors	1990
Protective effect of diltiazem against acetaminophen hepatotoxicity in mice. Liver, 1995, Volume: 15, Issue:1 Topics: Acetaminophen; Acetylcysteine; Animals; Calcium; Cell Survival; Chemical and Drug Induced Liver Injury; Diltiazem; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Liver; Mice	1995
Antagonism of acetaminophen hepatotoxicity by phospholipase A2 inhibitors. Research communications in chemical pathology and pharmacology, 1993, Volume: 79, Issue:1 Topics: Acetaminophen; Animals; Calcium; Cell Nucleus; Chemical and Drug Induced Liver Injury; Chlorpromazine; Diltiazem; DNA; Homeostasis; Male; Mice; Mitochondria, Liver; NADP; Oxidation-Reduction; Phospholipases A; Phospholipases A2	1993
Effect of nifedipine, verapamil, diltiazem and trifluoperazine on acetaminophen toxicity in mice. Archives of toxicology, 1995, Volume: 70, Issue:2 Topics: Acetaminophen; Animals; Aspartate Aminotransferases; Calcium Channel Blockers; Calmodulin; Cytochrome P-450 Enzyme System; Diltiazem; Glutathione; Lipid Peroxidation; Male; Mice; Microsomes, Liver; Nifedipine; Survival Rate; Trifluoperazine; Verapamil	1995
Effects of nifedipine, verapamil, diltiazem and trifluoperazine on the antinociceptive activity of acetaminophen. Methods and findings in experimental and clinical pharmacology, 2000, Volume: 22, Issue:10 Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Calcium Channel Blockers; Cell Fractionation; Diltiazem; Dopamine Antagonists; Drug Synergism; Liver; Male; Mice; Nifedipine; Pain Measurement; Trifluoperazine; Verapamil	2000
[Studies on octanol-water partition coefficient and nasal drug absorption]. Yao xue xue bao = Acta pharmaceutica Sinica, 1997, Volume: 32, Issue:6 Topics: Absorption; Acetaminophen; Animals; Diltiazem; Hydrogen-Ion Concentration; Male; Nasal Mucosa; Rats; Rats, Sprague-Dawley	1997
Utility of hepatocytes in predicting drug metabolism: comparison of hepatic intrinsic clearance in rats and humans in vivo and in vitro. Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:5 Topics: Acetaminophen; Animals; Benzodiazepinones; Chromans; Cryopreservation; Diazepam; Diltiazem; Hepatocytes; Humans; Imidazoles; In Vitro Techniques; Indoles; Metabolic Clearance Rate; Predictive Value of Tests; Quinolizines; Rats; Reproducibility of Results; Species Specificity; Tetrazoles; Thiazolidinediones; Time Factors; Troglitazone; Zidovudine	2003
Poly(ethylene-co-methyl acrylate) membranes as rate-controlling barriers for drug delivery systems: characterization, mechanical properties and permeability. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2005, Volume: 60, Issue:3 Topics: Acetaminophen; Acrylic Resins; Calorimetry, Differential Scanning; Delayed-Action Preparations; Diltiazem; Elasticity; Ibuprofen; Kinetics; Membranes, Artificial; Permeability; Solubility; Solutions; Solvents; Tensile Strength; Wettability	2005
Gastrointestinal transit monitoring and absorption of controlled-release pellets of diltiazem. Pharmaceutical development and technology, 2005, Volume: 10, Issue:3 Topics: Acetaminophen; Adult; Cecum; Delayed-Action Preparations; Diltiazem; Gastric Emptying; Gastrointestinal Transit; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Male; Solubility; Sulfasalazine	2005
Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environment international, 2007, Volume: 33, Issue:3 Topics: Acetaminophen; Aliivibrio fischeri; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticonvulsants; Antihypertensive Agents; Carbamazepine; Cimetidine; Daphnia; Diltiazem; Environmental Monitoring; Histamine H2 Antagonists; Korea; Lethal Dose 50; Oryzias; Quantitative Structure-Activity Relationship; Risk Assessment; Sulfonamides; Water Pollutants, Chemical	2007
Preparation of poly(-isopropylacrylamide) hollow beads as reservoir drug delivery systems. Journal of controlled release : official journal of the Controlled Release Society, 2006, Nov-28, Volume: 116, Issue:2 Topics: Acetaminophen; Acrylamides; Acrylic Resins; Alginates; Delayed-Action Preparations; Diltiazem; Drug Delivery Systems; Ethylenediamines; Glucuronic Acid; Hexuronic Acids; Kinetics; Polymers	2006
Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2009, Volume: 72, Issue:1 Topics: Acetaminophen; Cellulose; Chemistry, Pharmaceutical; Diltiazem; Drug Carriers; Drug Delivery Systems; Metoprolol; Polyethylene Glycols; Polymers; Polyvinyl Alcohol; Tablets, Enteric-Coated; Technology, Pharmaceutical; Temperature; Theophylline	2009
Composition, purity and perceived quality of street cocaine in France. The International journal on drug policy, 2010, Volume: 21, Issue:5 Topics: Acetaminophen; Adolescent; Adult; Caffeine; Central Nervous System Stimulants; Cocaine; Cocaine-Related Disorders; Data Collection; Diltiazem; Drug Contamination; Drug Users; Female; France; Humans; Illicit Drugs; Lidocaine; Male; Middle Aged; Smoking; Young Adult	2010