dihydroxyphenylalanine has been researched along with tolcapone in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (69.23) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bjurling, P; Hartvig, P; Hörnfelt, K; Långström, B; Lindner, KJ; Tedroff, J | 1 |
| Lang, A; Männistö, PT; Rauhala, P; Vasar, E | 1 |
| Gordin, A; Kaakkola, S; Männistö, PT | 1 |
| Kaakkola, S; Wurtman, RJ | 1 |
| Friedgen, B; Graefe, KH; Halbrügge, T | 1 |
| Antonini, A; Beer, HF; Günther, I; Nickles, RJ; Psylla, M; Reddy, GN; Reist, HW; Schubiger, PA; Vontobel, P; Zollinger, A | 1 |
| Ishii, S; Ishiwata, K; Nozaki, T; Senda, M; Shinoda, M | 1 |
| Buckley, KR; Chan, GL; Doudet, D; Endres, CJ; Holden, JE; Morrison, KS; Pate, BD; Ruth, TJ; Snow, BJ; Sossi, V; Vingerhoets, FJ | 1 |
| Fasth, KJ; Hartvig, P; Långström, B; Tedroff, J; Torstenson, R | 1 |
| Buhmann, C; Oechsner, M; Strauss, J; Stuerenburg, HJ | 1 |
| Bailey, DL; Brooks, DJ; Bryson, H; Ceravolo, R; Jorga, KM; Piccini, P | 1 |
| Cardoso, MA; de Carvalho, KA; de Francisco, TM; de Oliveira Vilhena, R; Gasparetto, JC; Guimarães de Francisco, TM; Martins, CA; Pontarolo, R; Ribeiro, RP | 1 |
| Cao, L; Hao, H; Hao, K; Li, F; Liu, H; Qi, Q; Wang, H | 1 |
1 review(s) available for dihydroxyphenylalanine and tolcapone
| Article | Year |
|---|---|
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase.
Topics: Animals; Behavior, Animal; Benzophenones; Catechol O-Methyltransferase Inhibitors; Catecholamines; Catechols; Dihydroxyphenylalanine; Humans; Levodopa; Microdialysis; Nitriles; Nitrophenols; Pentanones; Tolcapone; Tomography, Emission-Computed | 1994 |
1 trial(s) available for dihydroxyphenylalanine and tolcapone
| Article | Year |
|---|---|
18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease.
Topics: Aged; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Caudate Nucleus; Cross-Over Studies; Dihydroxyphenylalanine; Dopamine; Enzyme Inhibitors; Humans; Middle Aged; Neostriatum; Neurons; Nitrophenols; Parkinson Disease; Putamen; Tolcapone; Tomography, Emission-Computed | 2002 |
11 other study(ies) available for dihydroxyphenylalanine and tolcapone
| Article | Year |
|---|---|
Regional brain kinetics of 6-fluoro-(beta-11C)-L-dopa and (beta-11C)-L-dopa following COMT inhibition. A study in vivo using positron emission tomography.
Topics: Animals; Benzophenones; Brain; Carbon Radioisotopes; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dihydroxyphenylalanine; Female; Half-Life; Macaca mulatta; Methyldopa; Nitrophenols; Tolcapone; Tomography, Emission-Computed | 1992 |
Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression.
Topics: Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Depression; Desipramine; Dihydroxyphenylalanine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Levodopa; Male; Motor Activity; Nitriles; Nitrophenols; Rats; Rats, Wistar; Swimming; Tolcapone | 1995 |
Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum.
Topics: Animals; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Male; Nitriles; Nitrophenols; Rats; Rats, Sprague-Dawley; Tolcapone; Tyrosine | 1993 |
The part played by catechol-O-methyltransferase in the plasma kinetics of 3,4-dihydroxyphenylglycol and 3,4-dihydroxyphenylalanine in the anaesthetized rabbit.
Topics: Animals; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Female; Half-Life; Hemodynamics; Infusions, Intravenous; Male; Methoxyhydroxyphenylglycol; Nitrophenols; Norepinephrine; Rabbits; Tolcapone | 1993 |
Positron emission tomography in drug evaluation: influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-L-dopa in rhesus monkey.
Topics: Amidines; Animals; Benzophenones; Biological Availability; Brain; Catechol O-Methyltransferase Inhibitors; Catechols; Dihydroxyphenylalanine; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Fluorine Radioisotopes; Macaca mulatta; Nitriles; Nitrophenols; Pyridones; Tolcapone; Tomography, Emission-Computed | 1995 |
Synthesis and evaluation of an 18F-labeled dopa prodrug as a PET tracer for studying brain dopamine metabolism.
Topics: Animals; Benzophenones; Biotransformation; Brain; Carbidopa; Catechol O-Methyltransferase Inhibitors; Cerebral Cortex; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Enzyme Inhibitors; Fluorine Radioisotopes; Injections, Intravenous; Mice; Nitrophenols; Prodrugs; Time Factors; Tissue Distribution; Tolcapone; Tomography, Emission-Computed | 1996 |
Graphical analysis of 6-fluoro-L-dopa trapping: effect of inhibition of catechol-O-methyltransferase.
Topics: Animals; Benzophenones; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Enzyme Inhibitors; Fluorine Radioisotopes; Macaca fascicularis; Male; Nitrophenols; Pentanones; Tolcapone; Tomography, Emission-Computed | 1997 |
A comparison of 11C-labeled L-DOPA and L-fluorodopa as positron emission tomography tracers for the presynaptic dopaminergic system.
Topics: Animals; Antiparkinson Agents; Benzophenones; Carbon Radioisotopes; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Female; Fluorine Radioisotopes; Levodopa; Macaca mulatta; Nitrophenols; Presynaptic Terminals; Tolcapone; Tomography, Emission-Computed | 1999 |
COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Aged, 80 and over; Antiparkinson Agents; Benzophenones; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Disease Progression; Dose-Response Relationship, Drug; Female; Homovanillic Acid; Humans; Levodopa; Male; Middle Aged; Nitrophenols; Parkinson Disease; Tolcapone; Tyrosine | 2002 |
Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method.
Topics: Benzophenones; Blood Chemical Analysis; Carbidopa; Catechols; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Dopamine; Humans; Levodopa; Nitriles; Nitrophenols; Quality Control; Reproducibility of Results; Tandem Mass Spectrometry; Tolcapone; Tyrosine | 2015 |
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
Topics: Animals; Benzofurans; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Kinetics; Levodopa; Male; Metabolome; Methylation; Nitrophenols; Organ Specificity; Rats, Sprague-Dawley; Reproducibility of Results; Substrate Specificity; Tolcapone; Tyrosine | 2015 |