dihydroxyphenylalanine has been researched along with sapropterin in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (26.92) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 4 (15.38) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 1 (3.85) | 2.80 |
| Authors | Studies |
|---|---|
| Kaufman, S; Pigeon, D; Ribeiro, P | 1 |
| Ishii, A; Kaneda, N; Kohsaka, S; Nagatsu, T; Toya, S; Uchida, K | 1 |
| Hayaishi, O; Kagamiyama, H; Suzuki, S; Tsubokura, S; Watanabe, Y | 1 |
| Herken, H; Jung, W | 1 |
| Bräutigam, M; Herken, H; Kittner, B | 2 |
| Abou-Donia, MM; Iuvone, PM; Nichol, CA; Reinhard, JF; Viveros, OH | 1 |
| Mandell, AJ; Russo, PV | 1 |
| Bräutigam, M; Kittner, B; Laschinski, G | 1 |
| Koshimura, K; Miwa, S; Watanabe, Y | 1 |
| Kato, Y; Kido, T; Koshimura, K; Masaki, T; Miwa, S; Murakami, Y; Takagi, Y; Watanabe, Y | 1 |
| Bjurling, P; Hartvig, P; Kihlberg, T; Långström, B; Lindner, KJ; Tani, Y; Tsukada, H; Watanabe, Y; Westerberg, G | 1 |
| Kiuchi, K; Kobayashi, K; Mizuguchi, T; Morita, S; Nagatsu, T; Nakahara, D; Sawada, H | 1 |
| Anastasiadis, PZ; Kuhn, DM; Levine, RA; States, JC | 1 |
| Hidaka, H; Kaneda, N; Kiuchi, K; Nagatsu, T; Sasaoka, T | 1 |
| Koshimura, K; Miwa, S; Ohue, T; Watanabe, Y | 1 |
| Bjurling, P; Hartvig, P; Kihlberg, T; Långström, B; Lindner, KJ; Tani, Y; Tsukada, H; Valtysson, J; Watanabe, Y; Westerberg, G | 1 |
| Haavik, J | 1 |
| Kang, UJ; Leff, SE; Mandel, RJ; Rendahl, KG; Spratt, SK | 1 |
| Schallreuter, KU | 1 |
| Blau, N; Bonafé, L; Kierat, L; Leimbacher, W; Thöny, B | 1 |
| Choi, SW; Han, S; Jung, JH | 1 |
| Capistrano-Estrada, SB; Nyhan, WL | 1 |
| Björklund, T; Breysse, N; Carlsson, T; Carta, M; Hall, H; Kirik, D; Mandel, RJ; Soneson, C | 1 |
| Homma, D; Ichinose, H; Katoh, S; Tokuoka, H | 1 |
| Feist, AM; Herrgard, M; Kim, SH; Luo, H; Palsson, BØ; Wulff, T; Yang, L | 1 |
1 review(s) available for dihydroxyphenylalanine and sapropterin
| Article | Year |
|---|---|
A review of recent advances on the regulation of pigmentation in the human epidermis.
Topics: Albinism, Oculocutaneous; alpha-MSH; Biopterins; Dihydroxyphenylalanine; Enzyme Activation; Epidermis; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Intramolecular Oxidoreductases; Keratinocytes; Melanocytes; Melanosomes; Membrane Glycoproteins; Membrane Proteins; Monophenol Monooxygenase; Oxidative Stress; Oxidoreductases; Phenylalanine; Phenylalanine Hydroxylase; Pro-Opiomelanocortin; Proteins; Racial Groups; Recombinant Fusion Proteins; Skin Pigmentation; Transfection; Tyrosine; Tyrosine 3-Monooxygenase; Vitiligo | 1999 |
25 other study(ies) available for dihydroxyphenylalanine and sapropterin
| Article | Year |
|---|---|
The hydroxylation of phenylalanine and tyrosine by tyrosine hydroxylase from cultured pheochromocytoma cells.
Topics: Animals; Biopterins; Catalysis; Dihydroxyphenylalanine; Electrophoresis, Polyacrylamide Gel; Hydrogen Peroxide; Hydroxylation; Kinetics; Phenylalanine; Pheochromocytoma; Rats; Tumor Cells, Cultured; Tyrosine; Tyrosine 3-Monooxygenase | 1991 |
Tetrahydrobiopterin-dependent production of L-dopa in NRK fibroblasts transfected with tyrosine hydroxylase cDNA: future use for intracerebral grafting.
Topics: Animals; Biopterins; Cells, Cultured; Dihydroxyphenylalanine; DNA; Fibroblasts; Kidney; Rats; Transfection; Tyrosine 3-Monooxygenase | 1990 |
Decrease in tetrahydrobiopterin content and neurotransmitter amine biosynthesis in rat brain by an inhibitor of guanosine triphosphate cyclohydrolase.
Topics: 5-Hydroxytryptophan; Adrenal Glands; Aminohydrolases; Animals; Biogenic Amines; Biopterins; Brain; Dihydroxyphenylalanine; Dopamine; GTP Cyclohydrolase; Hydrazines; Hydroxyindoleacetic Acid; Hypoxanthines; Liver; Male; Neurotransmitter Agents; Norepinephrine; Organ Specificity; Rats; Rats, Inbred Strains; Serotonin | 1988 |
Inhibition of biopterin synthesis and DOPA production in PC-12 pheochromocytoma cells induced by 6-aminonicotinamide.
Topics: 6-Aminonicotinamide; Alcohol Oxidoreductases; Animals; Biopterins; Chromatography, High Pressure Liquid; Dihydropteridine Reductase; Dihydroxyphenylalanine; Gluconates; Niacinamide; Pheochromocytoma; Rats; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1989 |
Evaluation of neurotropic drug actions on tyrosine hydroxylase activity and dopamine metabolism in clonal cell lines.
Topics: Animals; Biopterins; Catechols; Cell Line; Clone Cells; Dihydroxyphenylalanine; Dopamine; Glioma; Mice; Neuroblastoma; Neurons; Tyrosine 3-Monooxygenase | 1985 |
Stimulation of retinal dopamine biosynthesis in vivo by exogenous tetrahydrobiopterin: relationship to tyrosine hydroxylase activation.
Topics: Animals; Biopterins; Dark Adaptation; Dihydroxyphenylalanine; Dopamine; Enzyme Activation; Light; Male; Pteridines; Rats; Rats, Inbred Strains; Retina; Tyrosine 3-Monooxygenase | 1985 |
Apomorphine does not decrease tissue levels of tetrahydrobiopterin in vivo.
Topics: Animals; Apomorphine; Biopterins; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; Liver; Male; Methotrexate; Rats; Rats, Inbred Strains | 1986 |
Metrics from nonlinear dynamics adapted for characterizing the behavior of nonequilibrium enzymatic rate functions.
Topics: Animals; Biopterins; Brain; Computers; Dihydroxyphenylalanine; Enzyme Activation; Enzymes; Kinetics; Models, Biological; Rats; Statistics as Topic; Tyrosine; Tyrosine 3-Monooxygenase | 1984 |
Inhibition of striatal tyrosine hydroxylase by low concentrations of apomorphine.
Topics: Animals; Apomorphine; Biopterins; Cells, Cultured; Corpus Striatum; Dihydroxyphenylalanine; In Vitro Techniques; Kinetics; Male; Neuroblastoma; Pheochromocytoma; Rats; Rats, Inbred Strains; Tyrosine 3-Monooxygenase | 1984 |
Dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: analysis of its action site using sepiapterin.
Topics: alpha-Methyltyrosine; Amino Acid Oxidoreductases; Analysis of Variance; Animals; Biopterins; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Isomerism; Kinetics; Male; Methyltyrosines; Microdialysis; Nitric Oxide Synthase; Pteridines; Pterins; Rats; Rats, Wistar; Time Factors; Tyrosine 3-Monooxygenase | 1994 |
Characterization of a dopamine-releasing action of 6R-L-erythro-tetrahydrobiopterin: comparison with a 6S-form.
Topics: Animals; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Male; Microdialysis; Rats; Rats, Wistar; Stereoisomerism; Tyrosine 3-Monooxygenase | 1995 |
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on in vivo L-[beta-11C]dopa turnover in the rat striatum with infusion of L-tyrosine.
Topics: Animals; Biopterins; Carbon Radioisotopes; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Extracellular Space; Homovanillic Acid; Male; Microdialysis; Molecular Structure; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed; Tyrosine | 1994 |
Peripherally administered (6R)-tetrahydrobiopterin increases in vivo tyrosine hydroxylase activity in the striatum measured by microdialysis both in normal mice and in transgenic mice carrying human tyrosine hydroxylase.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Humans; Hydrazines; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microdialysis; Reference Values; Tyrosine 3-Monooxygenase | 1994 |
Co-induction of tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adrenal Gland Neoplasms; Analysis of Variance; Animals; Biopterins; Dihydroxyphenylalanine; Dopamine; Enzyme Induction; Epinephrine; Homovanillic Acid; Kinetics; Norepinephrine; PC12 Cells; Pheochromocytoma; Rats; Serotonin; Tyrosine 3-Monooxygenase | 1993 |
Regulatory mechanism of dopamine biosynthesis in the striatum of transgenic mice carrying human tyrosine hydroxylase gene.
Topics: Animals; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Humans; Kinetics; Mice; Mice, Transgenic; Phosphorylation; Tyrosine 3-Monooxygenase | 1993 |
6R-L-erythro-5,6,7,8-tetrahydrobiopterin: a regulator of neurotransmitter release.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Hippocampus; Infusions, Parenteral; Kinetics; Male; Methyltyrosines; Microdialysis; Pteridines; Pterins; Rats; Rats, Wistar; Reserpine; Stereoisomerism | 1993 |
Effect of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin and infusion of L-tyrosine on the in vivo L-[beta-11C] DOPA disposition in the monkey brain.
Topics: Animals; Antioxidants; Biopterins; Brain; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Female; Macaca mulatta; Time Factors; Tyrosine | 1996 |
L-DOPA is a substrate for tyrosine hydroxylase.
Topics: Antioxidants; Basidiomycota; Biopterins; Dihydroxyphenylalanine; Humans; Kinetics; Levodopa; Monophenol Monooxygenase; Recombinant Proteins; Substrate Specificity; Tyrosine 3-Monooxygenase | 1997 |
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase.
Topics: 3T3 Cells; Animals; Antioxidants; Antiparkinson Agents; Apomorphine; Behavior, Animal; Biopterins; Corpus Striatum; Dihydroxyphenylalanine; Disease Models, Animal; Fibroblasts; Gene Expression Regulation, Enzymologic; Genetic Therapy; Gliosarcoma; GTP Cyclohydrolase; Humans; Levodopa; Male; Mice; Microdialysis; Parkinson Disease, Secondary; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; Retroviridae; Transformation, Genetic; Transgenes; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1998 |
Diagnosis of dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts.
Topics: Alcohol Oxidoreductases; Biopterins; Cell Extracts; Cells, Cultured; Cytokines; Dihydropteridine Reductase; Dihydroxyphenylalanine; Dopamine Agents; Dystonia; Female; Fibroblasts; GTP Cyclohydrolase; Humans; Male; Metabolism, Inborn Errors; Neopterin; Phosphorus-Oxygen Lyases; Reference Values; Skin | 2001 |
Indirect oxidation of 6-tetrahydrobiopterin by tyrosinase.
Topics: Biopterins; Dihydroxyphenylalanine; Monophenol Monooxygenase; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Substrate Specificity | 2004 |
6-pyruvoyl tetrahydropterin synthase deficiency: a case report.
Topics: 5-Hydroxytryptophan; Biopterins; Dihydroxyphenylalanine; Female; Humans; Infant, Newborn; Neonatal Screening; Neopterin; Phenylketonurias; Phosphorus-Oxygen Lyases | 2003 |
Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats.
Topics: Animals; Biopterins; Corpus Striatum; Dependovirus; Dihydroxyphenylalanine; Dopamine; Female; Genetic Therapy; GTP Cyclohydrolase; Immunohistochemistry; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Sympatholytics; Tyrosine 3-Monooxygenase | 2009 |
The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain.
Topics: Alcohol Oxidoreductases; Animals; Animals, Newborn; Biopterins; Blotting, Western; Brain; Catecholamines; Dihydroxyphenylalanine; Dopamine; Dopamine Agents; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Tyrosine 3-Monooxygenase | 2013 |
Directed Metabolic Pathway Evolution Enables Functional Pterin-Dependent Aromatic-Amino-Acid Hydroxylation in
Topics: 5-Hydroxytryptophan; Amino Acids, Aromatic; Biopterins; Dihydroxyphenylalanine; Directed Molecular Evolution; Escherichia coli; GTP Cyclohydrolase; Hydroxylation; Metabolic Networks and Pathways; Mutation; Phenylalanine Hydroxylase; Pterins; Tryptophan | 2020 |