dihydrouracil has been researched along with uracil in 128 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (17.19) | 18.7374 |
| 1990's | 22 (17.19) | 18.2507 |
| 2000's | 34 (26.56) | 29.6817 |
| 2010's | 37 (28.91) | 24.3611 |
| 2020's | 13 (10.16) | 2.80 |
| Authors | Studies |
|---|---|
| Bergene, R; Egtvedt, I; Henriksen, T; Sagstuen, E | 1 |
| Abeling, NG; Driedijk, PC; Elzinga, A; van Gennip, AH | 1 |
| Berger, R; Beukenhorst, H; de Bree, PK; Dorland, L; Duran, M; Rovers, P; Schreuder, CH | 1 |
| Abeling, NG; Busch, S; Scholten, EG; Stroomer, LE; van Gennip, AH | 1 |
| Engelbrecht, C; Yngner, T | 1 |
| Chaix, C; Duplaa, AM; Molko, D; Téoule, R | 1 |
| Schuchmann, HP; von Sonntag, C | 1 |
| Kraal, I; Lankelma, J; Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Cha, S; el Kouni, MH; Naguib, FN | 1 |
| Allerhand, A; Komoroski, RA | 1 |
| Schuchmann, MN; Steenken, S; von Sonntag, C; Wroblewski, J | 1 |
| Aubert, C; Cano, JP; Coassolo, P; Rigault, JP; Sommadossi, JP | 1 |
| Davis, CH; Putnam, MD; Thwaites, WM | 1 |
| Cronan, JE | 1 |
| O'Donovan, GA; Shanley, MS; West, TP | 1 |
| Scholes, G | 1 |
| Juechter, KB; Ma, P; Stevens, AR; Willaert, E | 1 |
| Durham, DR; Weber, JE | 1 |
| Anderson, DC; Cretton, EM; el Kouni, MH; Kidd, LB; McClure, HM; Sommadossi, JP | 1 |
| Imaeda, M; Kidouchi, K; Kobayashi, M; Kodama, K; Ohba, S; Sumi, S; Takeda, N; Tatematsu, A; Yamanaka, K; Yoshizumi, H | 1 |
| Epp, JB; Groutas, WC; Huang, H; McClenahan, JJ; Tagusagawa, F; Venkataraman, R | 1 |
| Cook, PF; Jahnke, K; Kautz, J; Podschun, B; Schnackerz, KD | 1 |
| Doetsch, PW; Liu, J; Zhou, W | 1 |
| Kidouchi, K; Ohba, S; Sumi, S; Wada, Y | 1 |
| Cook, PF; Gonzalez, FJ; Hagen, WR; Jahnke, K; Rosenbaum, K; Schaffrath, B; Schnackerz, KD | 1 |
| Ogawa, J; Prana, T; Shimizu, S; Soong, CL; Sri Prana, M; Sukiman, H | 1 |
| Doetsch, PW; Liu, J | 1 |
| De Abreu, RA; Van Gennip, AH; Van Kuilenburg, AB; Vreken, P | 1 |
| Asai, M; Hayashi, K; Imaeda, M; Kidouchi, K; Sumi, S; Wada, Y | 1 |
| Hamajima, N; Imaeda, M; Kidouchi, K; Kodama, K; Ohba, S; Sumi, S; Togari, H; Wada, Y | 1 |
| Hayashi, K; Kidouchi, K; Kumada, K; Mizokami, M; Orito, E; Sumi, S; Ueda, R; Wada, Y | 1 |
| Curti, B; Hagen, WR; Jahnke, K; Rosenbaum, K; Schnackerz, KD; Vanoni, MA | 1 |
| Bolton, PH; Clarkson, SG; Constantinou, A; Doetsch, PW; Gunz, D; Höss, M; Klungland, A; Lindahl, T; Wood, RD | 1 |
| Van Gennip, AH; Van Kuilenburg, AB; Van Lenthe, H | 1 |
| Doetsch, PW; Liu, J; Viswanathan, A | 1 |
| Boisdron-Celle, M; Delva, R; Gamelin, E; Genevieve, F; Guérin-Meyer, V; Ifrah, N; Larra, F; Lortholary, A; Robert, J | 1 |
| Hagen, WR; Rosenbaum, K; Schnackerz, KD; Vanoni, MA | 1 |
| Ito, T; Sumi, S; Ueta, A | 1 |
| Doetsch, PW; Donald, CD; Kow, YW; Roy, R; Venkhataraman, R; You, HJ | 1 |
| Chen, DJ; Donald, CD; Hashimoto, M; Kow, YW; Roy, R; Yannone, SM | 1 |
| Allinson, SL; Dianov, GL; Dianova, II | 1 |
| Hu, P; Hu, Y; Jiang, H; Jiang, J | 1 |
| Ishii, R; Koda, K; Miyazaki, M; Oda, K; Ooshima, H; Suzuki, H; Takiguchi, N | 1 |
| Martzen, MR; Phizicky, EM; Xing, F | 1 |
| Ackland, SP; Garg, MB; Sakoff, JA; Sevester, JC | 1 |
| Dianov, GL; Elder, RH | 1 |
| Ali, MM; Hashimoto, M; Imhoff, B; Kow, YW | 1 |
| DRISCOLL, CA; MILLER, CS; WRIGHT, LD | 1 |
| COHEN, SS; GREEN, M | 1 |
| FRITZSON, P | 1 |
| FRITZSON, P; PIHL, A | 1 |
| SLOTNICK, IJ; WEINFELD, H | 1 |
| CAMPBELL, LL | 1 |
| FEIT, PW | 1 |
| CIER, A; NOFRE, C; VINCENDON, G | 1 |
| Choudhury, S; Chung, FL; Frenkel, K; Kawamori, T; Roy, R; Zhang, R | 1 |
| Allinson, SL; Dianov, GL; Matthewman, GE; Sleeth, KM | 1 |
| Kulik, W; van Cruchten, A; van Kuilenburg, AB; van Lenthe, H | 1 |
| Ji, J; Jiang, H; Lu, J | 1 |
| Kikuchi, K; Masuike, T; Nakamura, A; Ohishi, T | 1 |
| Blachon, MF; Ciccolini, J; Durand, A; Favre, R; Lacarelle, B; Mercier, C | 1 |
| Hu, P; Jiang, H; Jiang, J; Lu, J | 1 |
| Amadori, D; Amatori, F; Bocci, G; Ciofi, L; Danesi, R; Del Tacca, M; Di Paolo, A; Falcone, A; Ibrahim, T; Lastella, M; Martelloni, BM; Vannozzi, F | 1 |
| Ali, MM; Hazra, TK; Hong, D; Kow, YW | 1 |
| Boisdron-Celle, M; Gamelin, E; Hameline, C; Morel, A; Remaud, G | 1 |
| Chen, IW; Ellis, JD; Embrey, MW; Felock, PJ; Funk, TW; Gabryelski, LJ; Hazuda, DJ; Homnick, CF; Jin, L; Leonard, YM; Lin, JH; Moyer, G; Perlow, DS; Schleif, WA; Stillmock, KA; Tsou, NN; Vacca, JP; Wai, JS; Witmer, MV; Wong, BK; Young, SD; Zhuang, L | 1 |
| Beumer, JH; Covey, JM; Egorin, MJ; Eiseman, JL; Joseph, E | 1 |
| Desmond, RA; Diasio, RB; Fourie, J; Hirao, Y; King, JR; Koga, T; Mattison, LK; Shimizu, T | 1 |
| Beijnen, JH; Bosch, TM; Jörger, M; Schellens, JH; Sparidans, RW | 1 |
| Amiand, M; Campion, L; Charbonnel, C; Déporte, R; Moreau, A | 1 |
| Grollman, AP; Kropachev, KY; Zharkov, DO | 1 |
| Beumer, JH; Covey, JM; D'argenio, DZ; Egorin, MJ; Eiseman, JL; Joseph, E; Parker, RS | 1 |
| Boisdron-Celle, M; Fey, L; Gamelin, E; Lainé-Cessac, P; Morel, A | 1 |
| Boisdron-Celle, M; Gamelin, E; Gamelin, L; Morel, A; Poirier, AL; Remaud, G; Traore, S | 1 |
| Chen, G; Chen, YB; Li, S; Lu, ZH; Pan, ZZ; Wan, de S; Wang, GQ; Zhou, ZW | 1 |
| Abeling, NG; Bosch, AM; Dobritzsch, D; Duran, M; Lohkamp, B; Meijer, J; Meinsma, R; van Kuilenburg, AB; van Tinteren, HL; Zoetekouw, L | 1 |
| Ben Ahmed, S; Ben Fredj, R; Gross, E; Hassine, H; Saguem, S | 1 |
| Hanauske, A; Hilger, RA; Krauss, J; Kredtke, S; Makris, L; Mende, B; Scheulen, ME; Scigalla, P; Strumberg, D; Thyssen, D; Urrea, PD | 1 |
| Blanco-Ania, D; Hermkens, PH; Rutjes, FP; Scheeren, HW; Sliedregt, LA; Valderas-Cortina, C | 1 |
| Boisdron-Celle, M; Cauchin, E; Galmiche, JP; Gamelin, E; Matysiak-Budnik, T; Morel, A; Mounier-Boutoille, H | 1 |
| Esaki, N; Hidese, R; Kurihara, T; Mihara, H | 2 |
| Bertone, M; Goettig, P; Gross, E; Haas, D; Kiechle, M; Magdolen, V; Meindl, A; van Kuilenburg, AB; Weidensee, S | 1 |
| Amidon, GL; Provoda, CJ; Tsume, Y | 1 |
| Ciccolini, J; Cordier, PY; Lacarelle, B; Mercier, C; Nau, A; Oliver, M; Peytel, E | 1 |
| Caroti, C; Cassola, G; D'Amico, M; Di Maria, E; Faravelli, F; Forzano, F; Fucile, C; Giorgio, E; Marini, V; Martelli, A; Mattioli, F; Parodi, MI; Uliana, V | 1 |
| Carlsson, G; Gustavsson, B; Odin, E; Wettergren, Y | 2 |
| Hirano, N; Nakamura, A; Suzuki, T; Tanaka, I; Tanaka, Y; Yamashita, K; Yao, M; Yu, F | 1 |
| Edwards, GL; Freeman, KG; Saba, CF; Schmiedt, CW | 2 |
| César, IC; Cunha-Júnior, GF; Duarte Byrro, RM; Pianetti, GA; Vaz Coelho, LG | 1 |
| Flentge, CA; Hutchinson, DK; Jiang, WW; Kati, WM; Lim, BH; Liu, Y; Madigan, DL; Maring, CJ; Molla, A; Randolph, JT; Wagner, R | 1 |
| Imoto, K; Ito, Y; Kobuchi, S; Kuwano, S; Okada, K; Takada, K | 2 |
| Lam, CW; Ma, CK; Siu, TS; Tam, S; Yau, MM; Yeung, CW | 1 |
| Imoto, K; Ito, Y; Kobuchi, S; Kuwano, S; Nishimura, A; Okada, K; Shibata, N; Takada, K | 1 |
| Balbo, S; Bandyopadhyay, D; Cheng, G; Hecht, SS; Khariwala, SS; Villalta, PW; Wang, M | 1 |
| Francés-Monerris, A; Merchán, M; Roca-Sanjuán, D | 1 |
| Andújar-Sánchez, M; Clemente-Jiménez, JM; Las Heras-Vázquez, FJ; Martínez-Gómez, AI; Martínez-Rodríguez, S; Neira, JL; Rodríguez-Vico, F; Soriano-Maldonado, P | 1 |
| Büchel, B; Fontana, S; Froehlich, TK; Joerger, M; Kummer, D; Largiadèr, CR; Sistonen, J; van Kuilenburg, AB | 1 |
| Achrainer, F; Zipse, H | 1 |
| Iles, RK; Trivedi, DK | 1 |
| Antunes, MV; Galarza, AF; Hahn, RZ; Linden, R; Schneider, A; Schwartsmann, G | 1 |
| Gelderblom, H; Guchelaar, HJ; Maring, JG; Opdam, F; van Kuilenburg, AB; van Staveren, MC | 1 |
| Bonadona, A; Chatelut, E; Delmas, C; Delord, JP; Dhelens, C; Garnier Tixidre, C; Goncalves, A; Hennebelle, I; Lochon, I; Penel, N; Thomas, F; Toulas, C | 1 |
| de Jong, RS; Gelderblom, H; Guchelaar, HJ; Maring, JG; Meijer, J; Punt, CJ; van Kuilenburg, AB; van Staveren, MC | 1 |
| Beijnen, JH; Burylo, AM; Cats, A; de Vries, N; Deenen, MJ; Huitema, AD; Jacobs, BA; Krähenbühl, MD; Meulendijks, D; Pluim, D; Rosing, H; Schellens, JH; van Geel, RM; van Hasselt, JG | 1 |
| Beijnen, JH; de Vries, N; Henricks, LM; Jacobs, BA; Meulendijks, D; Rosing, H; Schellens, JH | 1 |
| Aliev, A; Beijnen, JH; Cats, A; de Boer, A; de Vries, N; Deenen, MJ; Henricks, LM; Jacobs, BAW; Mandigers, CMPW; Meulendijks, D; Rosing, H; Schellens, JHM; Soesan, M; van Werkhoven, E | 1 |
| Feng, Y; Li, Y; Liu, H; Pan, W; Yang, F | 1 |
| Dobritzsch, D; Ito, T; Meijer, J; Meinsma, R; Nakajima, Y; Roelofsen, J; Tashiro, K; van Kuilenburg, ABP; Wang, X; Watanabe, Y; Zhang, C; Zoetekouw, L | 1 |
| Beijnen, JH; de Vries, N; Deenen, MJ; Jacobs, BAW; Koopman, M; Rosing, H; Samim, M; Schellens, JHM; Snoeren, N; van Hillegersberg, R | 1 |
| Beijnen, JH; Cats, A; de Vries, N; Guchelaar, HJ; Henricks, LM; Huitema, ADR; Jacobs, BAW; Meulendijks, D; Pluim, D; Rosing, H; Schellens, JHM; van den Broek, D | 1 |
| Antunes, MV; Cezimbra da Silva, AC; Linden, R; Muller, VV; Raymundo, S; Schwartsmann, G; Vicente Neto, OJ | 1 |
| Iwai, S; Shiraishi, M | 1 |
| Endutkin, AV; Makasheva, KA; Zharkov, DO | 1 |
| Aze, A; Basbous, J; Chaloin, L; Constantinou, A; Hodroj, D; Kim, B; Larroque, M; Lebdy, R; Maiorano, D; Mechali, M; Moreaux, J; Pruvost, A; Ribeyre, C; Shepard, C | 1 |
| Ciccolini, J; De Victor, B; Hilaire, V; Krache, A; Lacarelle, B; Lucas, M; Marin, C; Palmaro, C; Quaranta, S; Solas, C; Ugdonne, R | 1 |
| Abarca-Zabalía, J; García-Alfonso, P; García-González, X; Kaczmarczyk, B; López-Fernández, LA; Pachón, V; Robles, L; Salvador-Martín, S; Sanjurjo-Sáez, M; Thomas, F; Vaz, Á | 1 |
| Ishida, T; Mihara, H; Yoshioka, H | 1 |
| Capiau, S; Reyns, T; Stepman, H; Van Landschoot, A | 1 |
| Bukhari, SNA; Ejaz, H; Elsherif, MA; Janković, N | 1 |
| Benedetti, E; Bramanti, E; Campanella, B; Cremolini, C; Lomonaco, T; Marmorino, F; Nieri, R; Onor, M | 1 |
| Broeren, MAC; Brunsveld, L; Deenen, MJ; Hanrath, MA; Lapré, C; Scharnhorst, V; Streng, AS; van de Kerkhof, D; van den Broek, R; van den Wildenberg, SAH; van Dongen, JLJ | 1 |
| Bouwknegt, J; Luttik, MAH; Ortiz Merino, RA; Pronk, JT; van Cuylenburg, DC; Vos, AM | 1 |
| Aaron, R; Chacko, RT; Eriyat, V; Joel, A; Mathew, BS; Mathew, SK; Prabha, R; Singh, A; Sivamani, P | 1 |
| Beijnen, JH; Cats, A; Guchelaar, HJ; Knikman, JE; Rosing, H | 1 |
2 review(s) available for dihydrouracil and uracil
| Article | Year |
|---|---|
The radiolysis of pyrimidines in aqueous solutions: an updating review.
Topics: Cytosine; DNA; Free Radicals; Gamma Rays; Hydroxides; Hydroxyl Radical; Nucleosides; Nucleotides; Oxygen; Pyrimidines; Radiation-Sensitizing Agents; Solutions; Thymine; Uracil; Water | 1986 |
[Inborn errors of pyrimidine metabolism].
Topics: Diagnosis, Differential; Dihydrouracil Dehydrogenase (NADP); Humans; Intellectual Disability; Oxidoreductases; Purine-Pyrimidine Metabolism, Inborn Errors; Seizures; Uracil | 2000 |
8 trial(s) available for dihydrouracil and uracil
| Article | Year |
|---|---|
Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: A potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Chi-Square Distribution; Chromatography, Liquid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Uracil | 1999 |
Dihydropyrimidine dehydrogenase-related enzymes predict efficacy and adverse reactions of UFT1+cisplatin neoadjuvant chemotherapy for gastric cancer.
Topics: Amidohydrolases; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Dihydrouracil Dehydrogenase (NADP); Gastrectomy; Humans; Oxidoreductases; Predictive Value of Tests; Stomach Neoplasms; Tegafur; Uracil | 2002 |
Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: a potential biomarker for dihydropyrimidine dehydrogenase levels.
Topics: Adult; Animals; Biomarkers; Circadian Rhythm; Dihydrouracil Dehydrogenase (NADP); Enzyme-Linked Immunosorbent Assay; Female; Fluorouracil; Humans; Infusions, Intravenous; Liver; Male; Monocytes; Rats; Rats, Sprague-Dawley; Uracil | 2004 |
Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Antimetabolites, Antineoplastic; Chorionic Gonadotropin; Female; Floxuridine; Fluorouracil; Gestational Trophoblastic Disease; Humans; Leukocyte Count; Metabolic Clearance Rate; Neutrophils; Prodrugs; Prospective Studies; Uracil | 2004 |
The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Uracil; Vitamin B Complex | 2007 |
Evaluation of an oral uracil loading test to identify DPD-deficient patients using a limited sampling strategy.
Topics: Administration, Oral; Case-Control Studies; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Predictive Value of Tests; Sensitivity and Specificity; Uracil | 2016 |
The impact of liver resection on the dihydrouracil:uracil plasma ratio in patients with colorectal liver metastases.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Female; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Uracil | 2018 |
Food-effect study on uracil and dihydrouracil plasma levels as marker for dihydropyrimidine dehydrogenase activity in human volunteers.
Topics: Adult; Biomarkers; Cross-Over Studies; Dihydrouracil Dehydrogenase (NADP); Fasting; Female; Food; Healthy Volunteers; Humans; Male; Middle Aged; Uracil; Uridine | 2018 |
118 other study(ies) available for dihydrouracil and uracil
| Article | Year |
|---|---|
Radiation damage to dihydrouracil.
Topics: Electron Spin Resonance Spectroscopy; Molecular Conformation; RNA; Uracil; X-Ray Diffraction | 1978 |
Screening for defects of dihydropyrimidine degradation by analysis of amino acids in urine before and after acid hydrolysis.
Topics: Amidohydrolases; Amino Acids; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Hydrogen-Ion Concentration; Hydrolysis; Male; Oxidoreductases; Pyrimidines; Thymine; Uracil | 1992 |
Dihydropyrimidinuria: a new inborn error of pyrimidine metabolism.
Topics: Alanine; Amidohydrolases; Chromatography, High Pressure Liquid; Fibroblasts; Humans; Infant; Liver; Male; Neutrophils; Purine-Pyrimidine Metabolism, Inborn Errors; Spectrophotometry, Ultraviolet; Uracil | 1991 |
Simple method for the quantitative analysis of dihydropyrimidines and N-carbamyl-beta-amino acids in urine.
Topics: Amidohydrolases; Amino Acids; beta-Alanine; Chromatography, Ion Exchange; Humans; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1991 |
Metabolism of uridine and determination of liver ribonucleic acid synthesis in developing and adult mice.
Topics: Aging; Alanine; Animals; beta-Alanine; Liver; Male; Mice; Orotic Acid; RNA; Tritium; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate | 1985 |
Solid phase synthesis of the 5'-half of the initiator t-RNA from B. subtilis.
Topics: Bacillus subtilis; Base Sequence; Molecular Sequence Data; Oligonucleotides; RNA, Transfer, Amino Acid-Specific; RNA, Transfer, Met; Uracil | 1989 |
Effect of pyrimidine nucleosides on body temperatures of man and rabbit in relation to pharmacokinetic data.
Topics: Animals; beta-Alanine; Body Temperature Regulation; Cytidine; Dose-Response Relationship, Drug; Fever; Humans; Pyrimidine Nucleotides; Rabbits; Uracil; Uridine; Uridine Phosphorylase | 1987 |
Enzymes of uracil catabolism in normal and neoplastic human tissues.
Topics: Amidohydrolases; beta-Alanine; Dihydrouracil Dehydrogenase (NAD+); Fluorouracil; Humans; Kinetics; Neoplasms; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Uracil | 1985 |
Observation of resonances from some minor bases in the natural-abundance carbon-13 nuclear magnetic resonance spectrum of unfractionated yeast transfer ribonucleic acid. Evidence for fast internal motion of the dihydrouracil rings.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Fourier Analysis; Inosine; Magnesium; Magnetic Resonance Spectroscopy; Nucleotides; Pseudouridine; Ribose; RNA, Transfer; Saccharomyces cerevisiae; Thymine; Uracil; Uridine | 1974 |
Site of OH radical attack on dihydrouracil and some of its methyl derivatives.
Topics: Ferricyanides; Hydroxides; Hydroxyl Radical; Indicators and Reagents; Pentoxyl; Pulse Radiolysis; Radiochemistry; Tetramethylphenylenediamine; Tetranitromethane; Thymine; Uracil | 1984 |
Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Time Factors; Uracil | 1982 |
Metabolism of dihydrouracil in Rhodosporidium toruloides.
Topics: Basidiomycota; Carbon Dioxide; Mutation; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Uracil; Uridine Monophosphate; Ustilaginales | 1984 |
Beta-alanine synthesis in Escherichia coli.
Topics: Alanine; Aspartic Acid; beta-Alanine; Carboxy-Lyases; Chromosome Mapping; Escherichia coli; Genes; Glutamate Decarboxylase; Kinetics; Pantothenic Acid; Substrate Specificity; Uracil | 1980 |
Improved colorimetric procedure for quantitating N-carbamoyl-beta-alanine with minimum dihydrouracil interference.
Topics: Alanine; beta-Alanine; Colorimetry; Spectrophotometry; Uracil | 1982 |
Radiation effects on DNA. The Silvanus Thompson Memorial Lecture, April 1982.
Topics: Carbohydrates; DNA; Free Radicals; Oxygen; Purines; Pyrimidines; Radiochemistry; Solutions; Uracil; Water | 1983 |
A case of keratitis due to Acanthamoeba in New York, New York, and features of 10 cases.
Topics: Adult; Aged; Amoeba; Animals; Atropine; Dexamethasone; Female; Humans; Keratitis; Male; Mice; Microbial Sensitivity Tests; Middle Aged; Natamycin; Neomycin; New York City; Rifampin; Uracil | 1981 |
Properties of D-hydantoinase from Agrobacterium tumefaciens and its use for the preparation of N-carbamyl D-amino acids.
Topics: Agrobacterium tumefaciens; Amidohydrolases; Hydantoins; Hydrogen-Ion Concentration; Metals; Phenylacetates; Stereoisomerism; Substrate Specificity; Temperature; Uracil; Urea | 1995 |
Effects of 5-benzylacyclouridine, an inhibitor of uridine phosphorylase, on the pharmacokinetics of uridine in rhesus monkeys: implications for chemotherapy.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Macaca mulatta; Uracil; Uridine; Uridine Phosphorylase | 1995 |
Dihydropyrimidinuria: the first case in Japan.
Topics: Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Infant; Japan; Male; Mass Screening; Pilot Projects; Purine-Pyrimidine Metabolism, Inborn Errors; Pyrimidines; Thymine; Uracil | 1994 |
Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils.
Topics: Cathepsin G; Cathepsins; Drug Design; Humans; Leukocyte Elastase; Leukocytes; Magnetic Resonance Spectroscopy; Models, Molecular; Pancreatic Elastase; Serine Endopeptidases; Structure-Activity Relationship; Uracil | 1994 |
Acid-base catalytic mechanism of dihydropyrimidinase from pH studies.
Topics: Amidohydrolases; Animals; Binding Sites; Binding, Competitive; Catalysis; Cattle; Deuterium; Hydrogen-Ion Concentration; Kinetics; Liver; Piperidones; Swine; Uracil; Zinc | 1993 |
RNA polymerase bypass at sites of dihydrouracil: implications for transcriptional mutagenesis.
Topics: Adenine; Base Sequence; DNA Damage; DNA Repair; DNA-Directed RNA Polymerases; Escherichia coli; Guanine; Kinetics; Molecular Sequence Data; Mutagenesis; Mutagenesis, Insertional; Oligodeoxyribonucleotides; Point Mutation; RNA; Substrate Specificity; Templates, Genetic; Transcription, Genetic; Uracil; Viral Proteins | 1995 |
Automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography.
Topics: Adenine; Adenosine; Autoanalysis; Chromatography, High Pressure Liquid; Humans; Orotic Acid; Pseudouridine; Purine-Pyrimidine Metabolism, Inborn Errors; Uracil; Xanthine; Xanthines | 1995 |
Purification, characterization, and kinetics of porcine recombinant dihydropyrimidine dehydrogenase.
Topics: Animals; Binding, Competitive; Dihydrouracil Dehydrogenase (NADP); Electron Spin Resonance Spectroscopy; Flavins; Hydrogen-Ion Concentration; Iron; Kinetics; Oxidoreductases; Recombinant Proteins; Sulfides; Swine; Uracil | 1997 |
Distribution of cyclic imide-transforming activity in microorganisms.
Topics: Amidohydrolases; Bacteria; Hydantoins; Imides; Succinimides; Uracil; Yeasts | 1998 |
Escherichia coli RNA and DNA polymerase bypass of dihydrouracil: mutagenic potential via transcription and replication.
Topics: Base Sequence; DNA Replication; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; DNA, Bacterial; Escherichia coli; Kinetics; Molecular Sequence Data; Oligodeoxyribonucleotides; RNA, Bacterial; Templates, Genetic; Transcription, Genetic; Uracil | 1998 |
Clinical and biochemical aspects of dihydropyrimidinase deficiency.
Topics: Amidohydrolases; Biomarkers; Humans; Purine-Pyrimidine Metabolism, Inborn Errors; Reference Values; Thymine; Uracil | 1998 |
Urinary screening for pyrimidine metabolism disorders. Reference ranges for dihydrouracil, uracil, and dihydrouracil/uracil ratio.
Topics: Adult; Cerebral Infarction; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Hypertension; Liver Diseases; Male; Mass Screening; Middle Aged; Neoplasms; Oxidoreductases; Purine-Pyrimidine Metabolism, Inborn Errors; Reference Values; Uracil | 1998 |
Population and family studies of dihydropyrimidinuria: prevalence, inheritance mode, and risk of fluorouracil toxicity.
Topics: Adult; Amidohydrolases; Child; Child, Preschool; Female; Fluorouracil; Genes, Recessive; Homozygote; Humans; Infant; Japan; Male; Metabolism, Inborn Errors; Nuclear Family; Prevalence; Pyrimidines; Risk; Thymine; Uracil | 1998 |
Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Female; Fluorouracil; Humans; Male; Middle Aged; Uracil | 1996 |
Porcine recombinant dihydropyrimidine dehydrogenase: comparison of the spectroscopic and catalytic properties of the wild-type and C671A mutant enzymes.
Topics: Amino Acid Sequence; Animals; Catalysis; Cattle; Dihydrouracil Dehydrogenase (NADP); Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Oxidation-Reduction; Oxidoreductases; Photochemistry; Pyrimidine Nucleotides; Recombinant Proteins; Sequence Analysis; Spectrum Analysis; Sulfites; Swine; Uracil | 1998 |
Base excision repair of oxidative DNA damage activated by XPG protein.
Topics: Base Sequence; Binding Sites; Cockayne Syndrome; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Endonucleases; Enzyme Activation; Escherichia coli Proteins; Humans; Molecular Sequence Data; Mutation; Nuclear Proteins; Oxidative Stress; Pyrimidines; Recombinant Proteins; Transcription Factors; Uracil | 1999 |
A radiochemical assay for beta-ureidopropionase using radiolabeled N-carbamyl-beta-alanine obtained via hydrolysis of [2-(14)C]5, 6-dihydrouracil.
Topics: Amidohydrolases; beta-Alanine; Carbon Dioxide; Carbon Radioisotopes; Humans; Hydrolysis; Kinetics; Liver; Radioisotope Dilution Technique; Reproducibility of Results; Scintillation Counting; Sensitivity and Specificity; Uracil | 1999 |
E. coli RNA polymerase bypass of DNA base damage. Mutagenesis at the level of transcription.
Topics: Base Pairing; DNA Damage; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; Escherichia coli; Mutagenesis; Promoter Regions, Genetic; Templates, Genetic; Transcription, Genetic; Uracil | 1999 |
On the iron-sulfur clusters in the complex redox enzyme dihydropyrimidine dehydrogenase.
Topics: Amino Acid Sequence; Dihydrouracil Dehydrogenase (NADP); Dithionite; Electron Spin Resonance Spectroscopy; Iron-Sulfur Proteins; Molecular Sequence Data; NADP; Oxidation-Reduction; Oxidoreductases; Photochemistry; Titrimetry; Uracil | 2000 |
Enzymatic processing of DNA containing tandem dihydrouracil by endonucleases III and VIII.
Topics: Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; DNA, Bacterial; DNA, Fungal; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Oligonucleotides; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Substrate Specificity; Uracil | 2001 |
A possible role of Ku in mediating sequential repair of closely opposed lesions.
Topics: Antigens, Nuclear; Base Sequence; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Helicases; DNA Repair; DNA-Binding Proteins; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Humans; Kinetics; Ku Autoantigen; Models, Chemical; Molecular Sequence Data; Nuclear Proteins; Oligodeoxyribonucleotides; Substrate Specificity; Uracil | 2001 |
DNA polymerase beta is the major dRP lyase involved in repair of oxidative base lesions in DNA by mammalian cell extracts.
Topics: Animals; Base Sequence; Carbon-Oxygen Lyases; Cell Line; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA Damage; DNA Polymerase beta; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Fibroblasts; Guanine; Humans; Lyases; Mice; Mice, Knockout; Models, Genetic; Molecular Sequence Data; Mutation; Oxygen; Recombinant Proteins; Time Factors; Uracil | 2001 |
Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography-tandem mass spectrometry.
Topics: Calibration; Chromatography, High Pressure Liquid; Humans; Mass Spectrometry; Reference Values; Sensitivity and Specificity; Uracil | 2002 |
A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; DNA Primers; Escherichia coli; Fungal Proteins; Glutathione Transferase; Histidine; Molecular Sequence Data; Nucleic Acid Conformation; Open Reading Frames; Plasmids; Recombinant Fusion Proteins; RNA, Fungal; RNA, Transfer; RNA, Transfer, Leu; RNA, Transfer, Phe; RNA, Transfer, Tyr; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Templates, Genetic; Transcription, Genetic; Uracil | 2002 |
Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Uracil | 2002 |
Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.
Topics: Animals; Base Sequence; Cell-Free System; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Glycosylases; DNA Repair; Endodeoxyribonucleases; Escherichia coli Proteins; Mice; Mice, Knockout; Molecular Sequence Data; Mutation; N-Glycosyl Hydrolases; Oligodeoxyribonucleotides; Recombinant Proteins; Uracil | 2002 |
HU protein of Escherichia coli has a role in the repair of closely opposed lesions in DNA.
Topics: Bacterial Proteins; DNA; DNA Ligase ATP; DNA Ligases; DNA Polymerase I; DNA Repair; DNA-Binding Proteins; Escherichia coli; Exodeoxyribonucleases; Humans; Poly-ADP-Ribose Binding Proteins; Uracil; Xenopus Proteins | 2003 |
Inactivity of dihydrouracil and ureidopropionic acid as pyrimidine precursors for lactic acid bacteria.
Topics: Lactic Acid; Lactobacillus; Lipid Metabolism; Propionates; Pyrimidines; Uracil | 1954 |
Studies on the biosynthesis of bacterial and viral pyrimidines. II. Dihydrouracil and dihydrothymine nucleosides.
Topics: Nucleosides; Nucleotides; Pyrimidines; Thymine; Uracil | 1957 |
The catabolism of C14-labeled uracil, dihydrouracil, and beta-ureidopropionic acid in rat liver slices.
Topics: Alanine; Animals; beta-Alanine; Liver; Rats; Uracil; Urea | 1957 |
The catabolism of C14-labeled uracil, dihydrouracil, and beta-ureidopropionic acid in the intact rat.
Topics: Alanine; Animals; beta-Alanine; Rats; Uracil; Urea | 1957 |
Dihydrouracil as a growth factor for mutant strains of Escherichia coli.
Topics: Escherichia coli; Humans; Intercellular Signaling Peptides and Proteins; Pituitary Gland; Uracil | 1957 |
Reductive degradation of pyrimidines. IV. Purification and properties of dihydrouracil hydrase.
Topics: Clostridium; Hydro-Lyases; Pyrimidines; Uracil | 1958 |
[5-Trifluoromethyl-5-hydroxy-5, 6-dihydrouracil].
Topics: Uracil | 1962 |
[EFFECT OF GAMMA RAYS ON DIHYDROURACIL IN AQUEOUS SOLUTION].
Topics: Barbiturates; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography; Cobalt Isotopes; Gamma Rays; Radiation Effects; Research; Solutions; Uracil | 1965 |
Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats.
Topics: Animals; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; Hepatitis, Animal; Liver; Liver Neoplasms, Experimental; Male; Oxidative Stress; Rats; Rats, Inbred LEC; Rats, Long-Evans; RNA, Messenger; Uracil | 2003 |
Orchestration of base excision repair by controlling the rates of enzymatic activities.
Topics: Apurinic Acid; Cell-Free System; Cells, Cultured; DNA Glycosylases; DNA Repair; Guanine; Humans; Hypoxanthine; Lymphocytes; Poly(ADP-ribose) Polymerases; Polynucleotides; Uracil | 2004 |
Quantification of 5,6-dihydrouracil by HPLC-electrospray tandem mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Humans; Infant, Newborn; Spectrometry, Mass, Electrospray Ionization; Uracil; Uridine | 2004 |
[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].
Topics: Animals; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Liver; Male; Rats; Uracil | 2004 |
A simple and rapid high-performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Middle Aged; Polymorphism, Genetic; Uracil | 2004 |
Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling.
Topics: Aged; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Drug Monitoring; Female; Fluorouracil; Humans; Male; Middle Aged; Uracil | 2005 |
Action of human endonucleases III and VIII upon DNA-containing tandem dihydrouracil.
Topics: Bacteriophage T4; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endonucleases; Humans; Models, Biological; Polynucleotide 5'-Hydroxyl-Kinase; Substrate Specificity; Uracil | 2005 |
An accurate dihydrouracil/uracil determination using improved high performance liquid chromatography method for preventing fluoropyrimidines-related toxicity in clinical practice.
Topics: Chromatography, High Pressure Liquid; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Reproducibility of Results; Temperature; Time Factors; Uracil | 2005 |
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Topics: Animals; Benzyl Compounds; Biological Availability; Crystallography, X-Ray; HIV Integrase Inhibitors; HIV-1; Naphthyridines; Rats; Uracil; Virus Replication | 2005 |
Quantitative determination of zebularine (NSC 309132), a DNA methyltransferase inhibitor, and three metabolites in murine plasma by high-performance liquid chromatography coupled with on-line radioactivity detection.
Topics: Animals; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cytidine; DNA Modification Methylases; Drug Stability; Male; Mice; Mice, Inbred Strains; Online Systems; Reproducibility of Results; Sensitivity and Specificity; Specific Pathogen-Free Organisms; Spectrophotometry, Ultraviolet; Uracil; Uridine | 2006 |
The uracil breath test in the assessment of dihydropyrimidine dehydrogenase activity: pharmacokinetic relationship between expired 13CO2 and plasma [2-13C]dihydrouracil.
Topics: Administration, Oral; Adult; Aged; Breath Tests; Carbon Dioxide; Carbon Isotopes; Chromatography, High Pressure Liquid; Diagnostic Tests, Routine; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Male; Middle Aged; Neoplasms; Phenotype; Sensitivity and Specificity; Spectrophotometry, Infrared; Uracil | 2006 |
Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.
Topics: beta-Alanine; Biological Assay; Calibration; Capecitabine; Case-Control Studies; Child; Child, Preschool; Chromatography, Liquid; Deoxycytidine; Enzymes; Female; Fluorouracil; Humans; Infant, Newborn; Male; Pyrimidines; Spectrometry, Mass, Electrospray Ionization; Uracil | 2006 |
High-performance liquid chromatographic assay with UV detection for measurement of dihydrouracil/uracil ratio in plasma.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Uracil | 2006 |
Catalytic mechanism of Escherichia coli endonuclease VIII: roles of the intercalation loop and the zinc finger.
Topics: Amino Acid Substitution; Catalysis; Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Repair; DNA-Formamidopyrimidine Glycosylase; Escherichia coli; Escherichia coli Proteins; Mutation, Missense; Structural Homology, Protein; Substrate Specificity; Uracil; Zinc Fingers | 2006 |
A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice.
Topics: Animals; Chromatography, High Pressure Liquid; Cytidine; DNA Modification Methylases; Male; Mice; Uracil; Uridine | 2006 |
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
Topics: Adenine; Aged; Alleles; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; DNA, Complementary; Exons; Fatal Outcome; Female; Fluorouracil; Gene Frequency; Humans; Introns; Mutation; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thymine; Uracil | 2007 |
5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genetic Testing; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; RNA, Messenger; Uracil | 2007 |
Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency.
Topics: Amidohydrolases; Amino Acid Sequence; Animals; Brain; Child, Preschool; Crystallography, X-Ray; Dictyostelium; Enzyme Stability; Escherichia coli; Humans; Language Development Disorders; Magnetic Resonance Imaging; Male; Models, Molecular; Molecular Sequence Data; Mutation, Missense; Protein Conformation; Saccharomyces; Siblings; Thymine; Uracil | 2007 |
The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA; Female; Fluorouracil; Genetic Testing; Half-Life; Homozygote; Humans; Male; Middle Aged; Spectrophotometry, Ultraviolet; Uracil | 2009 |
Pharmacokinetic study of S-1.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Area Under Curve; beta-Alanine; Biological Availability; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fasting; Fluorouracil; Food; Gastric Acidity Determination; Half-Life; Humans; Hydrogen-Ion Concentration; Oxonic Acid; Pantoprazole; Pyridines; Tegafur; Triazines; Uracil | 2009 |
Synthesis of dihydrouracils spiro-fused to pyrrolidines: druglike molecules based on the 2-arylethyl amine scaffold.
Topics: Combinatorial Chemistry Techniques; Pyrrolidines; Small Molecule Libraries; Spiro Compounds; Uracil | 2010 |
Lethal outcome of 5-fluorouracil infusion in a patient with a total DPD deficiency and a double DPYD and UTG1A1 gene mutation.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fatal Outcome; Fluorouracil; Humans; Infusion Pumps; Liver Neoplasms; Male; Mutation; Phenotype; Uracil | 2010 |
Escherichia coli dihydropyrimidine dehydrogenase is a novel NAD-dependent heterotetramer essential for the production of 5,6-dihydrouracil.
Topics: Dihydrouracil Dehydrogenase (NADP); Dimerization; Escherichia coli; Escherichia coli Proteins; Kinetics; Molecular Sequence Data; NAD; Phylogeny; Uracil | 2011 |
A mild phenotype of dihydropyrimidine dehydrogenase deficiency and developmental retardation associated with a missense mutation affecting cofactor binding.
Topics: Amino Acid Sequence; Child; Creatinine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Flavin-Adenine Dinucleotide; Genotype; Humans; Male; Molecular Sequence Data; Mutation, Missense; Protein Binding; Sequence Homology, Amino Acid; Thymine; Uracil | 2011 |
The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; beta-Alanine; Cell Extracts; Cell Line, Tumor; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Linear Models; Mass Spectrometry; Reproducibility of Results; Uracil; Urea | 2011 |
5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases.
Topics: Aged; Antimetabolites, Antineoplastic; Brain; Dihydropyrimidine Dehydrogenase Deficiency; Electroencephalography; Epilepsy, Frontal Lobe; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Recovery of Function; Sigmoid Neoplasms; Tomography, X-Ray Computed; Uracil | 2011 |
Severe fluoropyrimidine-related toxicity: clinical implications of DPYD analysis and UH2/U ratio evaluation.
Topics: Antineoplastic Agents; Dihydrouracil Dehydrogenase (NADP); Female; Humans; Middle Aged; Pyrimidines; Uracil | 2011 |
Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-fluorouracil-based chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diarrhea; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Sex Characteristics; Thrombocytopenia; Uracil | 2012 |
Molecular basis of dihydrouridine formation on tRNA.
Topics: Amino Acid Sequence; Bacterial Proteins; Base Sequence; Binding Sites; Biocatalysis; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Flavin Mononucleotide; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Oxidation-Reduction; Oxidoreductases; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; RNA, Transfer; Sequence Homology, Amino Acid; Thermus thermophilus; Uracil; Uridine | 2011 |
Assessment of plasma uracil-to-dihydrouracil concentration ratio as an indicator of dihydropyrimidine dehydrogenase activity in clinically normal dogs and dogs with neoplasia or renal insufficiency.
Topics: Animals; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Dog Diseases; Dogs; Female; Male; Neoplasms; Renal Insufficiency; Uracil | 2012 |
A rapid HPLC-ESI-MS/MS method for determination of dihydrouracil/uracil ratio in plasma: evaluation of toxicity to 5-flurouracil in patients with gastrointestinal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uracil | 2012 |
Identification of aryl dihydrouracil derivatives as palm initiation site inhibitors of HCV NS5B polymerase.
Topics: Amino Acid Substitution; Genotype; Hepacivirus; Kinetics; Protease Inhibitors; Structure-Activity Relationship; Transcription Initiation Site; Uracil; Viral Nonstructural Proteins | 2012 |
Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Liver; Male; Rats; Rats, Wistar; Tumor Burden; Uracil | 2013 |
Pharmacokinetic/pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colon; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Male; Models, Biological; Rats; Rats, Wistar; Rectum; Uracil | 2013 |
Diagnosis of dihydropyrimidinase deficiency in a Chinese boy with dihydropyrimidinuria.
Topics: Child, Preschool; China; Dihydropyrimidine Dehydrogenase Deficiency; Hong Kong; Humans; Male; Metabolism, Inborn Errors; Mutation, Missense; Uracil | 2013 |
A predictive biomarker for altered 5-fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Liver; Male; Rats; Rats, Wistar; Uracil | 2013 |
Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation.
Topics: Animals; DNA; DNA Adducts; Guanine; Humans; Leukocytes; Liver; Male; Molecular Structure; Nitroso Compounds; Rats; Rats, Inbred F344; Sodium Nitrite; Uracil | 2013 |
Communication: Electronic UV-Vis transient spectra of the ∙OH reaction products of uracil, thymine, cytosine, and 5,6-dihydrouracil by using the complete active space self-consistent field second-order perturbation (CASPT2//CASSCF) theory.
Topics: Cytosine; Electrons; Hydroxyl Radical; Molecular Structure; Quantum Theory; Spectrophotometry, Ultraviolet; Thymine; Uracil | 2013 |
Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.
Topics: Aging; Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Male; Uracil | 2013 |
Biochemical and mutational studies of allantoinase from Bacillus licheniformis CECT 20T.
Topics: Allantoin; Allosteric Regulation; Amidohydrolases; Amino Acid Substitution; Bacillus; Bacterial Proteins; Catalytic Domain; Cobalt; Cysteine; Enzyme Inhibitors; Hydantoins; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Manganese; Molecular Weight; Mutagenesis, Site-Directed; Protein Binding; Stereoisomerism; Substrate Specificity; Transition Temperature; Uracil | 2014 |
Global identification of genes affecting iron-sulfur cluster biogenesis and iron homeostasis.
Topics: Escherichia coli; Escherichia coli Proteins; Gene Knockout Techniques; Homeostasis; Iron; Isotope Labeling; Metabolic Networks and Pathways; Sulfur; Uracil | 2014 |
Pretherapeutic uracil and dihydrouracil levels in saliva of colorectal cancer patients are associated with toxicity during adjuvant 5-fluorouracil-based chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Saliva; Sex Factors; Uracil | 2014 |
Predicting 5-fluorouracil toxicity: DPD genotype and 5,6-dihydrouracil:uracil ratio.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genotype; Humans; Male; Middle Aged; Uracil | 2014 |
Transfer hydrogenation in open-shell nucleotides - a theoretical survey.
Topics: Cytosine; Free Radicals; Hydrogenation; Models, Chemical; Nucleotides; Oxidation-Reduction; Thermodynamics; Uracil | 2014 |
Shotgun metabolomic profiles in maternal urine identify potential mass spectral markers of abnormal fetal biochemistry - dihydrouracil and progesterone in the metabolism of Down syndrome.
Topics: Adult; Biomarkers; Chromatography, Reverse-Phase; Down Syndrome; Female; Fetus; Humans; Hydrophobic and Hydrophilic Interactions; Metabolome; Metabolomics; Pregnancy; Prenatal Diagnosis; Progesterone; Tandem Mass Spectrometry; Uracil | 2015 |
Improved determination of uracil and dihydrouracil in plasma after a loading oral dose of uracil using high-performance liquid chromatography with photodiode array detection and porous graphitic carbon stationary phase.
Topics: Administration, Oral; Calibration; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Graphite; Humans; Porosity; Reproducibility of Results; Uracil | 2015 |
Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Uracil | 2015 |
Genotyping of a family with a novel deleterious DPYD mutation supports the pretherapeutic screening of DPD deficiency with dihydrouracil/uracil ratio.
Topics: Adult; Antimetabolites, Antineoplastic; Biotransformation; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA; Family; Fatal Outcome; Female; Fluorouracil; Gene Duplication; Genetic Variation; Genotype; Heterozygote; Humans; Male; Middle Aged; Mutation; Phenotype; Retrospective Studies; Uracil | 2016 |
Pronounced between-subject and circadian variability in thymidylate synthase and dihydropyrimidine dehydrogenase enzyme activity in human volunteers.
Topics: Adult; Circadian Rhythm; Dihydrouracil Dehydrogenase (NADP); Female; Gene Expression; Healthy Volunteers; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Plasma; Polymorphism, Genetic; Thymidylate Synthase; Uracil; Young Adult | 2016 |
Development and validation of a rapid and sensitive UPLC-MS/MS method for determination of uracil and dihydrouracil in human plasma.
Topics: Chromatography, High Pressure Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Humans; Tandem Mass Spectrometry; Temperature; Time Factors; Uracil | 2016 |
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Genotype; Hospitalization; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasms; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Predictive Value of Tests; Prospective Studies; Thymidylate Synthase; Uracil; Young Adult | 2017 |
A new sample preparation and separation combination for the precise, accurate, and simultaneous determination of uracil and dihydrouracil in human plasma by reversed-phase HPLC.
Topics: Calibration; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Humans; Reproducibility of Results; Sensitivity and Specificity; Specimen Handling; Uracil | 2017 |
Dihydropyrimidinase deficiency in four East Asian patients due to novel and rare DPYS mutations affecting protein structural integrity and catalytic activity.
Topics: Amidohydrolases; Asian People; Brain; Catalytic Domain; Child; Child, Preschool; Crystallization; Female; Gene Frequency; Genetic Variation; Humans; Infant; Japan; Male; Metabolism, Inborn Errors; Models, Molecular; Mutation, Missense; Point Mutation; Uracil | 2017 |
Determination of Endogenous Concentrations of Uracil and Dihydrouracil in Dried Saliva Spots by LC-MS/MS: Method Development, Validation, and Clinical Application.
Topics: Antimetabolites, Antineoplastic; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Humans; Saliva; Tandem Mass Spectrometry; Uracil | 2019 |
Molecular Basis of Substrate Recognition of Endonuclease Q from the Euryarchaeon Pyrococcus furiosus.
Topics: Archaeal Proteins; DNA Repair; Endonucleases; Pyrococcus furiosus; Substrate Specificity; Uracil | 2020 |
Requirements for DNA bubble structure for efficient cleavage by helix-two-turn-helix DNA glycosylases.
Topics: Deoxyribonuclease (Pyrimidine Dimer); DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; DNA-Formamidopyrimidine Glycosylase; DNA, Single-Stranded; Escherichia coli; Escherichia coli Proteins; Guanine; Humans; Nucleic Acid Conformation; Oxidative Stress; Transcription, Genetic; Uracil | 2020 |
Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; DNA Replication; Humans; Neoplasms; Transcription, Genetic; Uracil; Xenopus laevis | 2020 |
A Simple and Rapid UPLC-UV Method for Detecting DPD Deficiency in Patients With Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; Chromatography, High Pressure Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Spectrophotometry, Ultraviolet; Uracil | 2020 |
New DPYD variants causing DPD deficiency in patients treated with fluoropyrimidine.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Computer Simulation; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Retrospective Studies; Uracil | 2020 |
Overexpression and characterization of Escherichia coli dihydropyrimidine dehydrogenase: a four iron-sulphur cluster containing flavoprotein.
Topics: Animals; Catalysis; Dihydrouracil Dehydrogenase (NADP); Escherichia coli; Escherichia coli Proteins; Flavins; Flavoproteins; Histidine; Iron; Iron-Sulfur Proteins; Kinetics; Oligopeptides; Sulfur; Swine; Thymine; Uracil | 2021 |
Pre-analytical considerations for the analysis of uracil and 5,6-dihydrouracil in heparin plasma.
Topics: Fluorouracil; Heparin; Humans; Plasma; Uracil | 2022 |
Synthesis and Characterization of Dihydrouracil Analogs Utilizing Biginelli Hybrids.
Topics: Uracil; Uridine | 2022 |
Fast, Direct Dihydrouracil Quantitation in Human Saliva: Method Development, Validation, and Application.
Topics: Chromatography, Liquid; Humans; Saliva; Tandem Mass Spectrometry; Uracil | 2022 |
Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions.
Topics: Biomarkers; Capecitabine; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Tandem Mass Spectrometry; Thymine; Uracil | 2022 |
Identification of fungal dihydrouracil-oxidase genes by expression in Saccharomyces cerevisiae.
Topics: Cell Extracts; Genes, Fungal; Hydrogen; Hydrogen Peroxide; NAD; Proteome; Saccharomyces cerevisiae; Thymine; Uracil | 2022 |
Identification of
Topics: Dihydrouracil Dehydrogenase (NADP); Genotype; Humans; Phenotype; Uracil | 2023 |
Assay performance and stability of uracil and dihydrouracil in clinical practice.
Topics: Antimetabolites; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Humans; Tandem Mass Spectrometry; Uracil | 2023 |