dihydrouracil has been researched along with fluorouracil in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (5.41) | 18.7374 |
| 1990's | 3 (8.11) | 18.2507 |
| 2000's | 14 (37.84) | 29.6817 |
| 2010's | 14 (37.84) | 24.3611 |
| 2020's | 4 (10.81) | 2.80 |
| Authors | Studies |
|---|---|
| Cha, S; el Kouni, MH; Naguib, FN | 1 |
| Aubert, C; Cano, JP; Coassolo, P; Rigault, JP; Sommadossi, JP | 1 |
| Hamajima, N; Imaeda, M; Kidouchi, K; Kodama, K; Ohba, S; Sumi, S; Togari, H; Wada, Y | 1 |
| Hayashi, K; Kidouchi, K; Kumada, K; Mizokami, M; Orito, E; Sumi, S; Ueda, R; Wada, Y | 1 |
| Boisdron-Celle, M; Delva, R; Gamelin, E; Genevieve, F; Guérin-Meyer, V; Ifrah, N; Larra, F; Lortholary, A; Robert, J | 1 |
| Ackland, SP; Garg, MB; Sakoff, JA; Sevester, JC | 1 |
| Ji, J; Jiang, H; Lu, J | 1 |
| Kikuchi, K; Masuike, T; Nakamura, A; Ohishi, T | 1 |
| Blachon, MF; Ciccolini, J; Durand, A; Favre, R; Lacarelle, B; Mercier, C | 1 |
| Hu, P; Jiang, H; Jiang, J; Lu, J | 1 |
| Amadori, D; Amatori, F; Bocci, G; Ciofi, L; Danesi, R; Del Tacca, M; Di Paolo, A; Falcone, A; Ibrahim, T; Lastella, M; Martelloni, BM; Vannozzi, F | 1 |
| Boisdron-Celle, M; Gamelin, E; Hameline, C; Morel, A; Remaud, G | 1 |
| Beijnen, JH; Bosch, TM; Jörger, M; Schellens, JH; Sparidans, RW | 1 |
| Amiand, M; Campion, L; Charbonnel, C; Déporte, R; Moreau, A | 1 |
| Boisdron-Celle, M; Fey, L; Gamelin, E; Lainé-Cessac, P; Morel, A | 1 |
| Boisdron-Celle, M; Gamelin, E; Gamelin, L; Morel, A; Poirier, AL; Remaud, G; Traore, S | 1 |
| Chen, G; Chen, YB; Li, S; Lu, ZH; Pan, ZZ; Wan, de S; Wang, GQ; Zhou, ZW | 1 |
| Ben Ahmed, S; Ben Fredj, R; Gross, E; Hassine, H; Saguem, S | 1 |
| Hanauske, A; Hilger, RA; Krauss, J; Kredtke, S; Makris, L; Mende, B; Scheulen, ME; Scigalla, P; Strumberg, D; Thyssen, D; Urrea, PD | 1 |
| Boisdron-Celle, M; Cauchin, E; Galmiche, JP; Gamelin, E; Matysiak-Budnik, T; Morel, A; Mounier-Boutoille, H | 1 |
| Amidon, GL; Provoda, CJ; Tsume, Y | 1 |
| Ciccolini, J; Cordier, PY; Lacarelle, B; Mercier, C; Nau, A; Oliver, M; Peytel, E | 1 |
| Carlsson, G; Gustavsson, B; Odin, E; Wettergren, Y | 2 |
| César, IC; Cunha-Júnior, GF; Duarte Byrro, RM; Pianetti, GA; Vaz Coelho, LG | 1 |
| Imoto, K; Ito, Y; Kobuchi, S; Kuwano, S; Okada, K; Takada, K | 2 |
| Imoto, K; Ito, Y; Kobuchi, S; Kuwano, S; Nishimura, A; Okada, K; Shibata, N; Takada, K | 1 |
| Edwards, GL; Freeman, KG; Saba, CF; Schmiedt, CW | 1 |
| Büchel, B; Fontana, S; Froehlich, TK; Joerger, M; Kummer, D; Largiadèr, CR; Sistonen, J; van Kuilenburg, AB | 1 |
| Gelderblom, H; Guchelaar, HJ; Maring, JG; Opdam, F; van Kuilenburg, AB; van Staveren, MC | 1 |
| Bonadona, A; Chatelut, E; Delmas, C; Delord, JP; Dhelens, C; Garnier Tixidre, C; Goncalves, A; Hennebelle, I; Lochon, I; Penel, N; Thomas, F; Toulas, C | 1 |
| Aliev, A; Beijnen, JH; Cats, A; de Boer, A; de Vries, N; Deenen, MJ; Henricks, LM; Jacobs, BAW; Mandigers, CMPW; Meulendijks, D; Rosing, H; Schellens, JHM; Soesan, M; van Werkhoven, E | 1 |
| Ciccolini, J; De Victor, B; Hilaire, V; Krache, A; Lacarelle, B; Lucas, M; Marin, C; Palmaro, C; Quaranta, S; Solas, C; Ugdonne, R | 1 |
| Abarca-Zabalía, J; García-Alfonso, P; García-González, X; Kaczmarczyk, B; López-Fernández, LA; Pachón, V; Robles, L; Salvador-Martín, S; Sanjurjo-Sáez, M; Thomas, F; Vaz, Á | 1 |
| Capiau, S; Reyns, T; Stepman, H; Van Landschoot, A | 1 |
| Broeren, MAC; Brunsveld, L; Deenen, MJ; Hanrath, MA; Lapré, C; Scharnhorst, V; Streng, AS; van de Kerkhof, D; van den Broek, R; van den Wildenberg, SAH; van Dongen, JLJ | 1 |
4 trial(s) available for dihydrouracil and fluorouracil
| Article | Year |
|---|---|
Correlation between uracil and dihydrouracil plasma ratio, fluorouracil (5-FU) pharmacokinetic parameters, and tolerance in patients with advanced colorectal cancer: A potential interest for predicting 5-FU toxicity and determining optimal 5-FU dosage.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Chi-Square Distribution; Chromatography, Liquid; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Linear Models; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Uracil | 1999 |
Circadian rhythm of dihydrouracil/uracil ratios in biological fluids: a potential biomarker for dihydropyrimidine dehydrogenase levels.
Topics: Adult; Animals; Biomarkers; Circadian Rhythm; Dihydrouracil Dehydrogenase (NADP); Enzyme-Linked Immunosorbent Assay; Female; Fluorouracil; Humans; Infusions, Intravenous; Liver; Male; Monocytes; Rats; Rats, Sprague-Dawley; Uracil | 2004 |
Important role of the dihydrouracil/uracil ratio in marked interpatient variations of fluoropyrimidine pharmacokinetics and pharmacodynamics.
Topics: Adult; Antimetabolites, Antineoplastic; Chorionic Gonadotropin; Female; Floxuridine; Fluorouracil; Gestational Trophoblastic Disease; Humans; Leukocyte Count; Metabolic Clearance Rate; Neutrophils; Prodrugs; Prospective Studies; Uracil | 2004 |
The dihydrouracil/uracil ratios in plasma and toxicities of 5-fluorouracil-based adjuvant chemotherapy in colorectal cancer patients.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Uracil; Vitamin B Complex | 2007 |
33 other study(ies) available for dihydrouracil and fluorouracil
| Article | Year |
|---|---|
Enzymes of uracil catabolism in normal and neoplastic human tissues.
Topics: Amidohydrolases; beta-Alanine; Dihydrouracil Dehydrogenase (NAD+); Fluorouracil; Humans; Kinetics; Neoplasms; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Uracil | 1985 |
Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Time Factors; Uracil | 1982 |
Population and family studies of dihydropyrimidinuria: prevalence, inheritance mode, and risk of fluorouracil toxicity.
Topics: Adult; Amidohydrolases; Child; Child, Preschool; Female; Fluorouracil; Genes, Recessive; Homozygote; Humans; Infant; Japan; Male; Metabolism, Inborn Errors; Nuclear Family; Prevalence; Pyrimidines; Risk; Thymine; Uracil | 1998 |
Possible prediction of adverse reactions to pyrimidine chemotherapy from urinary pyrimidine levels and a case of asymptomatic adult dihydropyrimidinuria.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Female; Fluorouracil; Humans; Male; Middle Aged; Uracil | 1996 |
Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity.
Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Uracil | 2002 |
[Assay method for uracil, dihydrouracil, 5-fluorouracil and 5-fluoro-5, 6-dihydrouracil by high-performance liquid chromatography].
Topics: Animals; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Liver; Male; Rats; Uracil | 2004 |
A simple and rapid high-performance liquid chromatographic (HPLC) method for 5-fluorouracil (5-FU) assay in plasma and possible detection of patients with impaired dihydropyrimidine dehydrogenase (DPD) activity.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Middle Aged; Polymorphism, Genetic; Uracil | 2004 |
Improved analysis of 5-Fluorouracil and 5,6-dihydro-5-Fluorouracil by HPLC with diode array detection for determination of cellular dihydropyrimidine dehydrogenase activity and pharmacokinetic profiling.
Topics: Aged; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Dihydrouracil Dehydrogenase (NADP); Drug Monitoring; Female; Fluorouracil; Humans; Male; Middle Aged; Uracil | 2005 |
An accurate dihydrouracil/uracil determination using improved high performance liquid chromatography method for preventing fluoropyrimidines-related toxicity in clinical practice.
Topics: Chromatography, High Pressure Liquid; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Humans; Reproducibility of Results; Temperature; Time Factors; Uracil | 2005 |
Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.
Topics: beta-Alanine; Biological Assay; Calibration; Capecitabine; Case-Control Studies; Child; Child, Preschool; Chromatography, Liquid; Deoxycytidine; Enzymes; Female; Fluorouracil; Humans; Infant, Newborn; Male; Pyrimidines; Spectrometry, Mass, Electrospray Ionization; Uracil | 2006 |
High-performance liquid chromatographic assay with UV detection for measurement of dihydrouracil/uracil ratio in plasma.
Topics: Chromatography, High Pressure Liquid; Fluorouracil; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Uracil | 2006 |
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
Topics: Adenine; Aged; Alleles; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); DNA Mutational Analysis; DNA, Complementary; Exons; Fatal Outcome; Female; Fluorouracil; Gene Frequency; Humans; Introns; Mutation; Pedigree; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Thymine; Uracil | 2007 |
5-Fluorouracil-related severe toxicity: a comparison of different methods for the pretherapeutic detection of dihydropyrimidine dehydrogenase deficiency.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genetic Testing; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; RNA, Messenger; Uracil | 2007 |
The dihydrouracil/uracil ratio in plasma, clinical and genetic analysis for screening of dihydropyrimidine dehydrogenase deficiency in colorectal cancer patients treated with 5-fluorouracil.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA; Female; Fluorouracil; Genetic Testing; Half-Life; Homozygote; Humans; Male; Middle Aged; Spectrophotometry, Ultraviolet; Uracil | 2009 |
Pharmacokinetic study of S-1.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Anti-Ulcer Agents; Antimetabolites, Antineoplastic; Area Under Curve; beta-Alanine; Biological Availability; Clinical Trials as Topic; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Fasting; Fluorouracil; Food; Gastric Acidity Determination; Half-Life; Humans; Hydrogen-Ion Concentration; Oxonic Acid; Pantoprazole; Pyridines; Tegafur; Triazines; Uracil | 2009 |
Lethal outcome of 5-fluorouracil infusion in a patient with a total DPD deficiency and a double DPYD and UTG1A1 gene mutation.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fatal Outcome; Fluorouracil; Humans; Infusion Pumps; Liver Neoplasms; Male; Mutation; Phenotype; Uracil | 2010 |
The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS.
Topics: Analysis of Variance; Antimetabolites, Antineoplastic; beta-Alanine; Cell Extracts; Cell Line, Tumor; Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Linear Models; Mass Spectrometry; Reproducibility of Results; Uracil; Urea | 2011 |
5-FU-induced neurotoxicity in cancer patients with profound DPD deficiency syndrome: a report of two cases.
Topics: Aged; Antimetabolites, Antineoplastic; Brain; Dihydropyrimidine Dehydrogenase Deficiency; Electroencephalography; Epilepsy, Frontal Lobe; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasms; Neurotoxicity Syndromes; Recovery of Function; Sigmoid Neoplasms; Tomography, X-Ray Computed; Uracil | 2011 |
Pretherapeutic uracil and dihydrouracil levels of colorectal cancer patients are associated with sex and toxic side effects during adjuvant 5-fluorouracil-based chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diarrhea; Dihydropyrimidine Dehydrogenase Deficiency; Female; Fluorouracil; Humans; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Sex Characteristics; Thrombocytopenia; Uracil | 2012 |
A rapid HPLC-ESI-MS/MS method for determination of dihydrouracil/uracil ratio in plasma: evaluation of toxicity to 5-flurouracil in patients with gastrointestinal cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Female; Fluorouracil; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Molecular Structure; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uracil | 2012 |
Pre-therapeutic assessment of plasma dihydrouracil/uracil ratio for predicting the pharmacokinetic parameters of 5-fluorouracil and tumor growth in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Liver; Male; Rats; Rats, Wistar; Tumor Burden; Uracil | 2013 |
Pharmacokinetic/pharmacodynamic modeling of 5-fluorouracil by using a biomarker to predict tumor growth in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colon; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Male; Models, Biological; Rats; Rats, Wistar; Rectum; Uracil | 2013 |
A predictive biomarker for altered 5-fluorouracil pharmacokinetics following repeated administration in a rat model of colorectal cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Liver; Male; Rats; Rats, Wistar; Uracil | 2013 |
Indirect assessment of dihydropyrimidine dehydrogenase activity in cats.
Topics: Aging; Animals; Antimetabolites, Antineoplastic; Cat Diseases; Cats; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Gene Expression Regulation, Enzymologic; Male; Uracil | 2013 |
Pretherapeutic uracil and dihydrouracil levels in saliva of colorectal cancer patients are associated with toxicity during adjuvant 5-fluorouracil-based chemotherapy.
Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Saliva; Sex Factors; Uracil | 2014 |
Predicting 5-fluorouracil toxicity: DPD genotype and 5,6-dihydrouracil:uracil ratio.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Genotype; Humans; Male; Middle Aged; Uracil | 2014 |
Influence of metastatic disease on the usefulness of uracil pharmacokinetics as a screening tool for DPD activity in colorectal cancer patients.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Neoplasm Metastasis; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Uracil | 2015 |
Genotyping of a family with a novel deleterious DPYD mutation supports the pretherapeutic screening of DPD deficiency with dihydrouracil/uracil ratio.
Topics: Adult; Antimetabolites, Antineoplastic; Biotransformation; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); DNA; Family; Fatal Outcome; Female; Fluorouracil; Gene Duplication; Genetic Variation; Genotype; Heterozygote; Humans; Male; Middle Aged; Mutation; Phenotype; Retrospective Studies; Uracil | 2016 |
Pretreatment serum uracil concentration as a predictor of severe and fatal fluoropyrimidine-associated toxicity.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Drug-Related Side Effects and Adverse Reactions; Female; Fluorouracil; Genotype; Hospitalization; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasms; Pharmacogenomic Testing; Pharmacogenomic Variants; Phenotype; Predictive Value of Tests; Prospective Studies; Thymidylate Synthase; Uracil; Young Adult | 2017 |
A Simple and Rapid UPLC-UV Method for Detecting DPD Deficiency in Patients With Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Biomarkers; Capecitabine; Chromatography, High Pressure Liquid; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasms; Spectrophotometry, Ultraviolet; Uracil | 2020 |
New DPYD variants causing DPD deficiency in patients treated with fluoropyrimidine.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Computer Simulation; Dihydropyrimidine Dehydrogenase Deficiency; Dihydrouracil Dehydrogenase (NADP); Female; Fluorouracil; Humans; Male; Middle Aged; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Retrospective Studies; Uracil | 2020 |
Pre-analytical considerations for the analysis of uracil and 5,6-dihydrouracil in heparin plasma.
Topics: Fluorouracil; Heparin; Humans; Plasma; Uracil | 2022 |
Quantification of uracil, dihydrouracil, thymine and dihydrothymine for reliable dihydropyrimidine dehydrogenase (DPD) phenotyping critically depend on blood and plasma storage conditions.
Topics: Biomarkers; Capecitabine; Chromatography, Liquid; Dihydrouracil Dehydrogenase (NADP); Fluorouracil; Humans; Tandem Mass Spectrometry; Thymine; Uracil | 2022 |