dihydrotetrabenazine has been researched along with tetrabenazine in 225 studies
| Studies (dihydrotetrabenazine) | Trials (dihydrotetrabenazine) | Recent Studies (post-2010) (dihydrotetrabenazine) | Studies (tetrabenazine) | Trials (tetrabenazine) | Recent Studies (post-2010) (tetrabenazine) |
|---|---|---|---|---|---|
| 234 | 4 | 60 | 1,360 | 71 | 372 |
| Protein | Taxonomy | dihydrotetrabenazine (IC50) | tetrabenazine (IC50) |
|---|---|---|---|
| Synaptic vesicular amine transporter | Rattus norvegicus (Norway rat) | 0.0114 | |
| Synaptic vesicular amine transporter | Homo sapiens (human) | 0.0198 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (12.00) | 18.7374 |
| 1990's | 45 (20.00) | 18.2507 |
| 2000's | 83 (36.89) | 29.6817 |
| 2010's | 64 (28.44) | 24.3611 |
| 2020's | 6 (2.67) | 2.80 |
| Authors | Studies |
|---|---|
| Desnos, C; Laran, MP; Scherman, D | 1 |
| Costentin, J; Leroux-Nicollet, I; Naudon, L | 2 |
| Boja, JW; Carroll, FI; Kuhar, MJ; Rostène, W; Scherman, D | 1 |
| Alouf, JE; Buckle, M; Cesura, A; Da Prada, M; Geoffroy, C; Launay, JM; Mutel, V | 1 |
| Near, JA; Vincent, MS | 3 |
| Masuo, Y; Pélaprat, D; Rostène, W; Scherman, D | 1 |
| Bertocci, B; Cesura, AM; Da Prada, M | 1 |
| Masuo, Y; Montagne, MN; Pélaprat, D; Rostène, W; Scherman, D | 1 |
| Costentin, J; Darchen, F; Leroux-Nicollet, I; Scherman, D | 1 |
| Laduron, PM; Levy, C; Scherman, D | 1 |
| Desnos, C; Raynaud, B; Scherman, D; Vidal, S; Weber, MJ | 1 |
| Boschi, G; Henry, JP; Rips, R; Scherman, D | 1 |
| Janssen, PF; Laduron, PM; Scherman, D | 1 |
| Darchen, F; Masuo, Y; Rostene, W; Scherman, D; Vial, M | 1 |
| Agid, Y; Darchen, F; Desnos, C; Javoy-Agid, F; Pollak, P; Scherman, D | 1 |
| Gasnier, B; Henry, JP; Scherman, D | 1 |
| Agid, Y; Blin, J; Desnos, C; Javoy-Agid, F; Pierot, L; Raisman, R; Ruberg, M; Scherman, D | 1 |
| Gasnier, B; Henry, JP; Isambert, MF; Roisin, MP; Scherman, D | 2 |
| Chang, W; Cugier, DL; Meshgin-Azarian, S; Near, JA; Vincent, MS | 1 |
| Boschi, G; Scherman, D | 1 |
| Darchen, F; Desnos, C; Henry, JP; Scherman, D | 1 |
| Agid, Y; Ploska, A; Raisman, R; Scherman, D | 1 |
| Ellory, JC; Gasnier, B; Henry, JP | 1 |
| Jamali, F; Mehvar, R | 1 |
| Galloway, HM; McLean, S; Millingen, KS; Roberts, MS | 1 |
| Scherman, D | 1 |
| Near, JA | 1 |
| Scherman, D; Weber, MJ | 1 |
| Coornaert, S; Desplanches, G; Gasnier, B; Henry, JP; Roisin, MP; Scherman, D | 1 |
| Guillot, M; Henry, JP; Isambert, MF; Lenoir, G; Roisin, MP | 1 |
| Henry, JP; Jaudon, P; Scherman, D | 2 |
| Henry, JP; Scherman, D | 4 |
| Frey, K; Jewett, D; Kilbourn, M; Lee, L; Vander Borght, T | 1 |
| Aunis, D; Desnos, C; Henry, JP; Langley, K; Laran, MP | 1 |
| Denis, P; Nordmann, JP; Rostène, W; Saraux, H; Scherman, D | 1 |
| Agid, Y; Anglade, P; Brandel, JP; Duyckaerts, C; Hirsch, EC; Javoy-Agid, F; Lehéricy, S; Scherman, D; Villares, J | 1 |
| Agid, Y; Javoy-Agid, F; Ruberg, M; Scherman, D | 1 |
| Costentin, J; Leroux-Nicollet, I | 2 |
| Kish, SJ; Wilson, JM | 1 |
| Frey, K; Kilbourn, M | 1 |
| Frey, KA; Kilbourn, MR; Sherman, PS; Vander Borght, T | 1 |
| Frey, KA; Jewett, DM; Karlamangla, A; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Lee, LC; Vander Borght, TM | 1 |
| Albin, RL; Frey, KA; Gilman, S; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Vander Borght, TM | 1 |
| Frey, KA; Gilman, S; Jewett, DM; Junck, L; Kilbourn, MR; Koeppe, RA; Lee, LC; Little, R; Lohman, M; Martorello, S; Vander Borght, TM | 1 |
| Kilbourn, MR | 3 |
| Costentin, J; Edwards, RH; Leroux-Nicollet, I; Liu, Y; Naudon, L; Peter, D; Raisman-Vozari, R | 1 |
| Jewett, DM; Kilbourn, MR; Lee, LC | 1 |
| Heeg, MJ; Jewett, DM; Kilbourn, MR; Lee, LC | 1 |
| Chang, LJ; el-Awar, M; Guttman, M; Kish, SJ; Levey, AI; Robitaille, Y | 1 |
| Kilbourn, M; Sherman, P | 1 |
| Albin, R; Frey, KA; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Kume, A | 1 |
| Frey, KA; Kilbourn, MR; Wieland, DM | 1 |
| Frey, K; Kilbourn, M; Robinson, T | 1 |
| Edwards, RH; Ruoho, AE; Sievert, MK; Thiriot, DS | 1 |
| Goldin, M; Rehavi, M; Roz, N; Weizman, A | 1 |
| Crooks, PA; Dwoskin, LP; Teng, L | 1 |
| Adams, KM; Bandekar, R; Gilman, S; Heumann, M; Johnson-Greene, D; Junck, L; Kluin, KJ; Koeppe, RA; Martorello, S | 1 |
| Chan, GL; Oakes, TR; Ruth, TJ; Schulzer, M; Sossi, V | 1 |
| Agid, Y; Duyckaerts, C; Faucheux, B; Hauw, JJ; Herrero, MT; Hirsch, EC; Obeso, JA; Villares, J | 1 |
| Adam, M; Calne, DB; Chan, GL; Dobko, T; Doudet, DJ; Holden, JE; Morrison, KS; Ruth, TJ; Samii, A; Schulzer, M; Stoessl, AJ | 1 |
| Albin, RL; Bohnen, NI; Fink, JK; Frey, KA | 1 |
| Gilman, S; Heumann, M; Johanns, J; Junck, L; Kluin, KJ; Koeppe, RA; Little, R; Martorello, S | 1 |
| Frey, KA; Kilbourn, MR; Koeppe, RA; Kuhl, DE | 1 |
| Kilbourn, MR; Kuszpit, K; Sherman, P | 1 |
| Costentin, J; Leroux-Nicollet, I; Naudon, L; Raisman-Vozari, R; Vilpoux, C | 1 |
| Calne, DB; de la Fuente-Fernandez, R; Holden, JE; Lee, CS; Pal, PK; Ruth, TJ; Samii, A; Schulzer, M; Sossi, V; Stoessl, AJ; Wudel, J | 1 |
| Chan, G; Holden, JE; Krzywinski, M; Ruth, TJ; Sossi, V; Stoessl, AJ | 1 |
| Hogan, KA; Sonsalla, PK; Staal, RG | 1 |
| Brown, JM; Fleckenstein, AE; Hanson, GR | 2 |
| Albin, RL; Bohnen, NI; Ficaro, E; Frey, KA; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Meyer, P; Wernette, K | 1 |
| Carr, JM; Frey, KA; Giordani, BJ; Huguelet, P; Kilbourn, MR; Koeppe, RA; Ohl, LE; Zubieta, JK | 1 |
| Dannals, RF; Hilton, J; Ravert, HT; Szabo, Z; Wong, DF; Yokoi, F | 1 |
| Frey, KA; Koeppe, RA; Tandon, R; Taylor, SF; Zubieta, JK | 1 |
| Boulay, D; Costentin, J; Leroux-Nicollet, I; Naudon, L | 1 |
| Rehavi, M; Weizman, A; Zucker, M | 1 |
| Ficaro, EP; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Raffel, DM; Snyder, SE | 1 |
| Stoessl, AJ | 1 |
| Kilbourn, MR; Kuszpit, K; Sherman, PS | 1 |
| Brown, JM; Fleckenstein, AE; Gibb, JW; Hansen, JP; Hanson, GR; Riddle, EL; Sandoval, V | 1 |
| Crosby, MJ; Fleckenstein, AE; Hanson, GR; Hanson, JE | 1 |
| Rehavi, M; Roz, N; Weizman, A | 1 |
| Rehavi, M; Valevski, A; Weizman, A; Zucker, M | 1 |
| Boulanger, JF; Di Paolo, T; Ekue, A; Morissette, M | 1 |
| Fleckenstein, AE; Hanson, GR; Riddle, EL; Sandoval, V | 1 |
| Aviv, A; Rehavi, M; Shelef, A; Weizman, A; Zucker, M | 1 |
| Rehavi, M; Schwartz, K; Weizman, A; Yadid, G | 1 |
| Calne, DB; De La Fuente-Fernández, R; Furtado, S; Furukawa, Y; Guttman, M; Lee, CS; Ruth, TJ; Stoessl, AJ | 1 |
| An, H; Chervin, RD; Consens, FB; Gilman, S; Heumann, M; Junck, L; Koeppe, RA; Little, R | 2 |
| Cho, AK; Kuczenski, R; Melega, WP; O'Neil, ML; Segal, DS | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Kilbourn, MR; Koeppe, RA; Meyer, P; Minoshima, S; Nichols, TE; Wernette, K | 1 |
| Kumar, A; Lee, CS; Mann, S; Ruth, TJ; Schulzer, M; Sossi, V; Stoessl, AJ | 1 |
| Albers, DS; Augood, SJ; Breakefield, XO; Hollingsworth, Z; Leung, J; Standaert, DG; Yang, L | 1 |
| Cleren, C; Costentin, J; Naudin, B | 1 |
| Brooks, DJ; Frey, KA; Marek, KL; Oakes, D; Paty, D; Prentice, R; Shults, CW; Stoessl, AJ | 1 |
| Doudet, DJ; Holden, JE | 1 |
| Edwards, RH; Freeman, J; Liu, Y; Near, JA; Parsons, J; Whitley, J | 1 |
| Fantegrossi, WE; Hatzidimitriou, G; Kilbourn, M; Ricaurte, GA; Sherman, P; Winger, G; Woods, JH; Woolverton, WL; Yuan, J | 1 |
| An, H; Gilman, S; Giordani, B; Heumann, M; Junck, L; Koeppe, RA; Little, R; Persad, C; Wernette, K | 1 |
| Del Pozzo, G; Hardy, MA; Harris, PE; Herold, K; Liu, E; Liu, Z; Maffei, A; Moschella, F; Winchester, RJ; Witkowski, P | 1 |
| Desmond, TJ; Frey, KA; Kemmerer, ES; Kilbourn, MR; Sherman, PS | 1 |
| Calne, DB; de la Fuente-Fernández, R; Kuramoto, L; Lee, CS; Mak, E; Ruth, TJ; Schulzer, M; Sossi, V; Stoessl, AJ | 1 |
| Ahlskog, JE; Albin, RL; Brooks, DJ; Carbon, M; Dhawan, V; Eidelberg, D; Fahn, S; Feigin, A; Guttman, M; Gwinn-Hardy, K; Holloway, R; Innis, R; Katz, RG; Kieburtz, K; Kish, SJ; Lange, N; Langston, JW; Marek, K; McFarland, H; Morin, L; Moy, C; Murphy, D; Oertel, WH; Oliver, G; Palesch, Y; Powers, W; Ravina, B; Seibyl, J; Sethi, KD; Sheehy, P; Shults, CW; Stoessl, AJ | 1 |
| Laor, N; Lask, M; Luski, A; Rehavi, M; Roz, N; Toren, P; Weizman, A | 1 |
| Rehavi, M; Schwartz, K; Weizman, A | 1 |
| Camborde, ML; Doudet, DJ; Newport, D; Rahmim, A; Ruth, TJ; Sossi, V; Tropini, G | 1 |
| Albin, RL; Frey, KA; Gilman, S; Heumann, M; Joshi, A; Junck, L; Koeppe, RA; Little, R; Liu, S | 1 |
| Adams, JR; Calne, DB; Farrer, M; Gasser, T; Lee, CS; Mak, E; Mckenzie, J; Ruth, TJ; Schulzer, M; Sossi, V; Stoessl, AJ; Strongosky, A; Uitti, RJ; van Netten, H; Wszolek, ZK | 1 |
| Gilad, R; Hermesh, H; Laufer, N; Marom, S; Nir, V; Rehavi, M; Weizman, A; Zucker, M | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Kilbourn, MR; Koeppe, RA; Minoshima, S; Wernette, KA | 1 |
| Goland, R; Hardy, M; Harris, PE; Kilbourn, M; Leibel, R; Maffei, A; Mann, JJ; Raffo, A; Saxena, C; Simpson, N; Souza, F; Van Heertum, R | 1 |
| Baumann, MH; Blough, BE; Dempsey, AG; Nagpal, AS; Partilla, JS; Rothman, RB | 1 |
| Goswami, R; Hou, C; Kilbourn, MR; Kung, HF; Kung, MP; Ponde, DE | 2 |
| Hardy, MA; Harris, PE; Herold, K; Herron, A; Jurewicz, A; Kilbourn, M; Liu, E; Maffei, A; Raffo, A; Simpson, NR; Souza, F; Van Heertum, R; Witkowski, P | 1 |
| Camborde, ML; Doudet, DJ; Greene, J; Holden, JE; Kornelsen, RA; McCormick, SE; Ruth, TJ; Sossi, V; Studenov, AR; Topping, GJ | 1 |
| Apter, A; Ben-Dor, DH; Rehavi, M; Roz, N; Sever, J; Weizman, A; Zimmerman, S | 1 |
| Goswami, R; Hockley, B; Hou, C; Kilbourn, MR; Kung, HF; Kung, MP; Lee, L; Ponde, DE | 1 |
| Adams, RJ; Alexander, M; Brasić, JR; Burton, NC; Chen, MK; Guilarte, TR; Kumar, A; Kuwabara, H; McGlothan, JL; Verina, T; Wong, DF; Zhou, Y | 1 |
| Harris, P; Leibel, R; Mann, JJ; Murthy, R; Parsey, R; Simpson, N; Van Heertum, R | 1 |
| Martin, WR; Schulzer, M; Stoessl, AJ; Wieler, M | 1 |
| Häkkinen, M; Storvik, M; Tiihonen, J; Tupala, E | 1 |
| Blankemeyer, E; Hou, C; Kilbourn, MR; Kung, HF; Kung, MP; Lieberman, BP; Oya, S; Ponde, DE; Skovronsky, D | 1 |
| Frey, KA; Gilman, S; Junck, L; Koeppe, RA; Wernette, K | 1 |
| Boileau, I; Houle, S; Kish, SJ; Tong, J; Wilson, AA | 1 |
| Deng, S; Harris, PE; Ichise, M; Landry, DW; Raffo, A; Xie, Y | 1 |
| Hasegawa, K; Kowa, H; Stoessl, AJ; Wszolek, ZK; Yagishita, S; Yokoyama, T | 1 |
| Alexander, M; Burton, NC; Griswold, M; Guilarte, TR; McGlothan, JL; Pham, L; Schneider, JS; Syversen, T; Verina, T; Wong, DF; Zhou, Y | 1 |
| Boileau, I; Guttman, M; Houle, S; Kish, SJ; Rusjan, P; Saint-Cyr, JA; Selby, P; Tong, J; Wilkins, D; Wilson, AA | 1 |
| de la Fuente-Fernandez, R; Mak, E; Ruth, TJ; Schulzer, M; Sossi, V; Stoessl, AJ; Troiano, AR | 1 |
| Albin, RL; Fink, JK; Koeppe, RA; Rainier, S | 1 |
| Fagan, SP; Fischman, AJ | 1 |
| Butler, PC; Freeby, M; Goland, R; Harris, PE; Hirsch, J; Ichise, M; Kumar, D; Leibel, RL; Maffei, A; Mann, JJ; Parsey, R; Prince, M; Saisho, Y; Simpson, N; Van Heertum, R | 1 |
| Vingerhoets, FJ | 1 |
| Amarasinghe, KK; Dinn, SR; Johnson, BF; Rishel, MJ | 1 |
| Albin, RL; Frey, KA; Kilbourn, MR; Koeppe, RA; Nichols, T; Wernette, K; Zhuang, W | 1 |
| de la Fuente-Fernández, R; McCormick, S; Ruth, TJ; Schulzer, M; Sossi, V; Stoessl, AJ | 1 |
| Fessler, JA; Joshi, AD; Kilbourn, MR; Koeppe, RA | 1 |
| Arbizu, J; Blesa, J; Collantes, M; Juri, C; Luquin, MR; Martí-Climent, JM; Obeso, JA; Peñuelas, I; Prieto, E; Quincoces, G; Richter, JA; Riverol, M; Rodriguez-Oroz, MC; Zubieta, JL | 1 |
| Farnsworth, SJ; Fleckenstein, AE; Hanson, GR; Volz, TJ | 1 |
| Louchami, K; Malaisse, WJ; Sener, A | 1 |
| Kung, HF; Liu, J; Zhu, L | 1 |
| Chagkutip, J; Crooks, PA; Dwoskin, LP; Nickell, JR; Vartak, AP | 1 |
| Anderson, LL; Cozzi, NV; Daley, PF; Feih, JT; Gopalakrishnan, A; Ruoho, AE; Shulgin, AT | 1 |
| Ahmed, L; Bessler, M; Durak, E; Freeby, MJ; Harris, P; Inabnet, WB; Korner, J; Lifante, JC; Milone, L; Sebastian, M | 1 |
| de la Fuente-Fernandez, R; Mak, E; McCormick, S; McKenzie, J; Ruth, TJ; Schulzer, M; Sossi, V; Stoessl, AJ; Troiano, AR | 1 |
| Butch, ER; Desmond, T; Frey, KA; Harris, PE; Kilbourn, MR; Sherman, P | 1 |
| Boileau, I; Furukawa, Y; Houle, S; Kish, SJ; Rusjan, PM; Selby, P; Tong, J; Wilkins, D; Wilson, AA | 1 |
| Chang, DJ; Jung, JK; Jung, JW; Kim, NJ; Moon, H; Paek, SM; Shin, D; Suh, YG | 1 |
| Arbizu, J; Blesa, J; Cavada, C; Collantes, M; García-García, D; Iglesias, E; Juri, C; Martí-Climent, J; Obeso, JA; Peñuelas, I; Prieto, E; Richter, JA; Rodríguez-Oroz, MC; Zubieta, JL | 1 |
| Albin, RL; Burke, JF; Frey, KA; Gilman, S; Giordani, B; Kilbourn, MR; Koeppe, RA | 2 |
| Rehavi, M; Simchon, Y; Weizman, A | 1 |
| Bormans, GM | 1 |
| Arponen, E; Fagerholm, V; Haaparanta, M; Ishizu, T; Kauhanen, S; Mikkola, KK; Någren, K; Nuutila, P; Solin, O | 1 |
| Au, WL; Calne, DB; Cragg, J; de la Fuente-Fernández, R; Kuramoto, L; Lee, CS; Mak, E; McCormick, S; McKenzie, J; Ramachandiran, N; Ruth, TJ; Schulzer, M; Sossi, V; Stoessl, AJ | 1 |
| Greig, NH; Katz, JL; Kopajtic, T; Sun, H; Wei, X; Wu, X; Yao, Z | 1 |
| Laor, N; Rehavi, M; Roz, N; Toren, P; Weizman, A; Zalsman, G | 1 |
| Choi, SR; Kung, HF; Lieberman, BP; Plöessl, K; Zheng, P | 1 |
| Albin, RL; Bogan, CW; Bohnen, NI; Frey, KA; Kilbourn, MR; Koeppe, RA; Müller, ML; Zarzhevsky, N | 1 |
| Aslanov-Farbstein, D; Laor, N; Rehavi, M; Roz, N; Toren, P; Vermeiren, R; Weizman, A; Zalsman, G | 1 |
| Kung, MP; Lin, KJ; Skovronsky, DM; Tsao, HH; Wey, SP; Yen, TC | 1 |
| Aasly, JO; Armaly, J; Furay, AR; Hasegawa, K; Leverenz, JB; Shi, M; Sossi, V; Stoessl, AJ; Uitti, RJ; Wang, Y; Wszolek, ZK; Yokoyama, T; Zabetian, CP; Zhang, J | 1 |
| Cho, YS; Kwon, TH; Lee, JK; Lee, JY; Min, SJ; Pae, AN; Son, YW | 1 |
| Daley, DC; Frankle, WG; Himes, M; Lopresti, BJ; Martinez, D; Mason, NS; Mathis, CA; May, MA; Narendran, R; Price, JC | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Gilman, S; Kilbourn, MR; Koeppe, RA; Kotagal, V; Müller, ML | 1 |
| Altmann, KH; Johannes, M | 1 |
| Alavi, A; Blomberg, BA; Eriksson, O; Saboury, B | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Koeppe, RA; Kotagal, V; Müller, ML; Petrou, M | 1 |
| Brown, CA; Flores, HP; Karimi, M; Loftin, SK; Moerlein, SM; Perlmutter, JS; Tian, L; Videen, TO | 1 |
| Dinelle, K; Doudet, DJ; Flores, J; Jing, Y; Mackey, S | 1 |
| Albin, RL; Burke, JF; Frey, KA; Gilman, S; Giordani, B; Koeppe, RA | 1 |
| Crooks, PA; Deaciuc, AG; Dwoskin, LP; Nickell, JR; Penthala, NR; Ponugoti, PR | 1 |
| Brown, CA; Flores, H; Karimi, MK; Loftin, SK; Moerlein, SM; Perlmutter, JS; Su, Y; Tabbal, SD; Tian, L | 1 |
| Bohnen, NI; Dayalu, P; Kwak, Y; Miller, NS; Müller, ML; Seidler, RD | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Koeppe, RA; Kotagal, V; Müller, ML; Scott, PJ; Studenski, S | 1 |
| Chen, Z; Huang, H; Li, X; Liu, C; Tan, C; Tang, J; Yu, H; Zou, P | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Koeppe, RA; Kotagal, V; Müller, ML | 1 |
| Hsiao, IT; Hsieh, CJ; Kung, MP; Lin, KJ; Lin, WY; Lu, CS; Weng, YH; Wey, SP; Yen, TC | 1 |
| Agarwal, PA; Appel-Cresswell, S; Dinelle, K; Farrer, MJ; Felicio, AC; Heffernan, N; McKenzie, J; Road, JD; Schulzer, M; Sossi, V; Stoessl, AJ; Wszolek, ZK | 1 |
| Albin, RL; Bohnen, NI; Constantine, GM; Frey, KA; Koeppe, RA; Kotagal, V; Müller, ML; Scott, PJ; Studenski, S | 1 |
| Blesa, J; Cavada, C; Hornykiewicz, O; Obeso, JA; Pifl, C; Rajput, A; Rajput, AH; Reither, H | 1 |
| Bradberry, CW; Himes, ML; Jedema, HP; Lopresti, BJ; Mason, NS; Narendran, R | 1 |
| Bohnen, NI; Chou, KL; Koeppe, RA; Lenhart, A | 1 |
| Aoki, N; Baker, M; Boeve, BF; Dickson, DW; Fujioka, S; Parisi, JE; Rademakers, R; Ross, OA; Sanchez-Contreras, M; Sossi, V; Stoessl, AJ; Strongosky, AJ; Tacik, P; Wszolek, ZK | 1 |
| Appel-Cresswell, S; Dickson, DW; Dinelle, K; Farrer, MJ; McCormick, SE; McKenzie, J; Rajput, A; Rajput, AH; Robinson, CA; Silva, V; Sossi, V; Stoessl, AJ; Thompson, C; Vilariño-Güell, C | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Koeppe, RA; Kotagal, V; Müller, ML; Petrou, M; Scott, PJ | 1 |
| Kumar, A; Lo, ST; Öz, OK; Sun, X | 1 |
| Collantes, M; Delgado, M; Ecay, M; Gago, B; Iglesias, E; Juri, C; Marín, C; Molinet-Dronda, F; Obeso, JA; Peñuelas, I; Prieto, E; Quiroga-Varela, A | 1 |
| Barajas, M; Collantes, M; Ecay, M; Escalada, J; Martí-Climent, JM; Peñuelas, I; Quincoces, G; Ramos-Membrive, R; Rodríguez, S | 1 |
| Crooks, PA; Ding, D; Dwoskin, LP; Nickell, JR | 1 |
| Boileau, I; Furukawa, Y; Houle, S; Kish, SJ; McCluskey, T; Tong, J | 1 |
| Albin, RL; Bohnen, NI; Frey, KA; Koeppe, RA; Kotagal, V; Müller, ML; Petrou, M; Scott, PJ; Shah, N | 1 |
| Albin, RL; Bohnen, NI; Davatzikos, C; Foerster, BR; Frey, KA; Herman, WH; Hsieh, M; Koeppe, RA; Kotagal, V; Müller, ML; Petrou, M | 1 |
| Hao, X; Jin, Q; Laffitte, B; Li, C; Shen, W; Va, P; Wu, TY | 1 |
| Bocato, MZ; de Albuquerque, NCP; de Gaitani, CM; de Lima Moreira, F; de Oliveira, ARM | 1 |
| Hsin, LW; Huang, YY; Huang, ZR; Shiue, CY; Tsai, CL; Tzen, KY; Yen, RF | 1 |
| Arponen, E; Asser, A; Bergquist, J; Eltermaa, M; Grönroos, T; Haaparanta-Solin, M; Kõks, S; Lindmäe, H; Nairismägi, J; Piip, P; Rinne, JO; Sauk, M; Snellman, A; Soomets, U; Taba, P | 1 |
| Bassett, AS; Boot, E; Butcher, NJ; Chow, EWC; Christopher, L; Fritsch, R; Lang, AE; Marras, C; Masellis, M; Pondal, M; Repetto, GM; Rusjan, P; Strafella, AP | 1 |
| Bohnen, JLB; Bohnen, NI; Haugen, J; Müller, MLTM | 1 |
| Gjedde, A; Jakobsen, S; Landau, AM; Phan, JA; Romero-Ramos, M; Stokholm, K; Vang, K; Zareba-Paslawska, J | 1 |
| Bozigian, H; Grigoriadis, DE; Loewen, G; O'Brien, CF; Skor, H; Smith, EB | 1 |
| Avendaño-Estrada, A; Ávila-Rodríguez, MA | 1 |
| Barrett, MJ; Bassett, AS; Berman, BD; Booij, J; Boot, E; Borg, M; Bourdain, F; Butcher, NJ; Charles, P; Clerinx, K; Colin, O; Danaila, T; Drapier, S; Dufournet, B; Fiksinski, AM; Gasser, T; Jacquette, A; Kaneko, S; Lang, AE; Marras, C; Masellis, M; Mills, K; Mok, KY; Mutez, E; Nguyen, K; Perandones, C; Plate, A; Prontera, P; Swillen, A; Udow, S; Vergaelen, E; Vogels, A; Williams, NM; Wood, NW | 1 |
| Hsiao, IT; Jung Lung, H; Lin, KJ; Wen, MC; Weng, YH | 1 |
| Cervantes-Arriaga, A; Díaz-Meneses, IE; Kerik, NE; Pérez-Lohman, C; Rodríguez-Violante, M | 1 |
| Albin, RL; Archer, DB; Bohnen, NI; Burciu, RG; Müller, MLTM; Ofori, E; Roy, A; Vaillancourt, DE; Yang, J | 1 |
| Calabro, F; Campbell, E; Larsen, B; Laymon, C; Luna, B; Minhas, D; Montez, D; Olafsson, V; Price, J; Tervo-Clemmens, B | 1 |
| Checkoway, H; Criswell, SR; Lenox-Krug, J; Moerlein, SM; Nielsen, SS; Perlmutter, JS; Racette, BA; Sheppard, L; Warden, MN | 1 |
| Bohnen, NI; D'Cruz, N; Kanel, P; Müller, MLTM; Sanchez-Catasus, CA; Yeh, FC | 1 |
| Du, G; Tian, J; Wang, H; Wang, W; Yang, Y; Ye, L; Yu, D; Zhang, R; Zhu, X; Zou, F | 1 |
| Bai, X; Du, G; Lin, S; Lu, J; Tian, J; Wang, H; Wang, W; Ye, L; Zhang, R | 1 |
| Brar, S; Grigoriadis, DE; Jimenez, R; Loewen, G; Scott, FL; Vijan, A; Zhang, H | 1 |
6 review(s) available for dihydrotetrabenazine and tetrabenazine
| Article | Year |
|---|---|
[Molecular pharmacology of the catecholamine transporter of chromaffin granules from the bovine adrenal medulla].
Topics: 3-Iodobenzylguanidine; Adenosine Triphosphate; Adrenal Medulla; Amines; Animals; Binding Sites; Binding, Competitive; Biological Transport; Carrier Proteins; Catecholamine Plasma Membrane Transport Proteins; Cattle; Chromaffin Granules; Chromaffin System; Dicyclohexylcarbodiimide; Electrochemistry; Intracellular Membranes; Iodobenzenes; Kinetics; Membrane Transport Proteins; Norepinephrine; Protons; Reserpine; Tetrabenazine | 1986 |
Molecular pharmacology of the monoamine transporter of the chromaffin granule membrane.
Topics: Amines; Animals; Binding Sites; Catecholamines; Chromaffin Granules; Chromaffin System; Intracellular Membranes; Reserpine; Tetrabenazine | 1987 |
Assessing the integrity of the dopamine system in Parkinson's disease: how best to do it?
Topics: Brain; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Fluorine Radioisotopes; Humans; Neural Pathways; Parkinson Disease; Severity of Illness Index; Substantia Nigra; Tetrabenazine; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 2001 |
Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease.
Topics: Animals; Basal Ganglia; Biomarkers; Cocaine; Diagnostic Imaging; Dihydroxyphenylalanine; Disease Progression; Dopamine Plasma Membrane Transport Proteins; Humans; Levodopa; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuropeptides; Parkinson Disease; Radiopharmaceuticals; Technology Assessment, Biomedical; Tetrabenazine; Tomography, Emission-Computed, Single-Photon; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
The role of radiotracer imaging in Parkinson disease.
Topics: Biomarkers; Biotransformation; Blood-Brain Barrier; Carbon Radioisotopes; Clinical Trials as Topic; Cocaine; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Forecasting; Humans; Iodine Radioisotopes; Neurons; Parkinson Disease; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Receptors, Dopamine; Substantia Nigra; Tetrabenazine; Tomography, Emission-Computed, Single-Photon | 2005 |
Noninvasive imaging of pancreatic beta cells.
Topics: Diagnostic Imaging; Humans; Insulin-Secreting Cells; Staining and Labeling; Tetrabenazine | 2009 |
4 trial(s) available for dihydrotetrabenazine and tetrabenazine
| Article | Year |
|---|---|
Dual-[11C]tracer single-acquisition positron emission tomography studies.
Topics: Brain; Carbon Radioisotopes; Central Nervous System Diseases; Computer Simulation; Flumazenil; GABA Modulators; Humans; Models, Biological; Propionates; Tetrabenazine; Tomography, Emission-Computed | 2001 |
REM sleep behavior disorder is related to striatal monoaminergic deficit in MSA.
Topics: Adult; Age Distribution; Aged; Binding, Competitive; Biogenic Monoamines; Carbon Radioisotopes; Corpus Striatum; Electromyography; Female; Humans; Iodine Radioisotopes; Male; Middle Aged; Multiple System Atrophy; Piperidines; Polysomnography; Predictive Value of Tests; Reference Values; REM Sleep Behavior Disorder; Sex Distribution; Tetrabenazine; Tetrahydronaphthalenes; Thalamus; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon | 2003 |
Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA.
Topics: Adult; Age Distribution; Aged; Binding, Competitive; Carrier Proteins; Corpus Striatum; Female; Humans; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Multiple System Atrophy; Neuropeptides; Pilot Projects; Piperidines; Pons; Receptors, Cholinergic; Reference Values; Regression Analysis; Sex Distribution; Sleep Apnea, Obstructive; Tetrabenazine; Tetrahydronaphthalenes; Thalamus; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Vesicular Acetylcholine Transport Proteins; Vesicular Biogenic Amine Transport Proteins; Vesicular Transport Proteins | 2003 |
Altered affinity of the platelet vesicular monoamine transporter 2 to dihydrotetrabenazine in children with major depression.
Topics: Adolescent; Blood Platelets; Child; Depressive Disorder, Major; Female; Humans; Male; Pilot Projects; Protein Binding; Radioligand Assay; Tetrabenazine; Tritium; Vesicular Monoamine Transport Proteins | 2011 |
215 other study(ies) available for dihydrotetrabenazine and tetrabenazine
| Article | Year |
|---|---|
Regulation of the chromaffin granule catecholamine transporter in cultured bovine adrenal medullary cells: stimulus-biosynthesis coupling.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholinesterase; Adrenal Medulla; Animals; Biological Transport; Carbachol; Carrier Proteins; Catecholamine Plasma Membrane Transport Proteins; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromogranin A; Chromogranins; Colforsin; Cyclic AMP; Cycloheximide; Dactinomycin; Dopamine beta-Hydroxylase; Membrane Proteins; Membrane Transport Proteins; Nifedipine; Potassium; Protein Kinase C; Tetrabenazine; Time Factors; Tritium; Tyrosine 3-Monooxygenase | 1992 |
Consequences of an intrastriatal injection of kainic acid on the dopaminergic neuronal and vesicular uptake systems.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Autoradiography; Binding Sites; Biological Transport; Choline; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Homovanillic Acid; Kainic Acid; Male; Membrane Proteins; Microinjections; Nerve Tissue Proteins; Neurons; Piperazines; Rats; Rats, Sprague-Dawley; Synaptosomes; Tetrabenazine; Tritium | 1992 |
Dopamine transport: pharmacological distinction between the synaptic membrane and the vesicular transporter in rat striatum.
Topics: Animals; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; In Vitro Techniques; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Synaptic Membranes; Synaptic Vesicles; Tetrabenazine | 1992 |
One-step purification of the serotonin transporter located at the human platelet plasma membrane.
Topics: Biological Transport; Blood Platelets; Blood Proteins; Carrier Proteins; Cell Membrane; Chromatography, Affinity; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Humans; Ouabain; Paroxetine; Piperidines; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Tetrabenazine | 1992 |
Purification of a [3H]dihydrotetrabenazine-binding protein from bovine adrenal medulla.
Topics: Adrenal Medulla; Animals; Anion Exchange Resins; Binding Sites; Carrier Proteins; Cattle; Chromatography, Liquid; Durapatite; Electrophoresis, Polyacrylamide Gel; Hydroxyapatites; Kinetics; Protein Binding; Resins, Synthetic; Sepharose; Sodium Dodecyl Sulfate; Tetrabenazine; Tritium; Wheat Germ Agglutinins | 1991 |
[3H]Dihydrotetrabenazine, a new marker for the visualization of dopaminergic denervation in the rat striatum.
Topics: Animals; Autoradiography; Corpus Striatum; Denervation; Dopamine; Hydroxydopamines; Kinetics; Male; Oxidopamine; Rats; Rats, Inbred Strains; Reference Values; Substantia Nigra; Tetrabenazine; Tritium; Tyrosine 3-Monooxygenase | 1990 |
Binding of [3H]dihydrotetrabenazine and [125I]azidoiodoketanserin photoaffinity labeling of the monoamine transporter of platelet 5-HT organelles.
Topics: Affinity Labels; Animals; Azides; Biogenic Monoamines; Blood Platelets; Blood Proteins; Cell Membrane; Guinea Pigs; Humans; In Vitro Techniques; Iodine Radioisotopes; Ketanserin; Paroxetine; Photochemistry; Piperidines; Rabbits; Rats; Receptors, Serotonin; Subcellular Fractions; Tetrabenazine | 1990 |
Regulation of neurotensin-containing neurons in the rat striatum. Effects of unilateral striatal lesions with quinolinic acid and ibotenic acid on neurotensin content and its binding site density.
Topics: Animals; Binding Sites; Biogenic Amines; Corpus Striatum; Functional Laterality; gamma-Aminobutyric Acid; Ibotenic Acid; Male; Neurons; Neurotensin; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Neurotensin; Receptors, Neurotransmitter; Reference Values; Stereotaxic Techniques; Sulpiride; Tetrabenazine | 1990 |
Postnatal development of the monoamine vesicular transporter in mesencephalic and telencephalic regions of the rat brain: a quantitative autoradiographic study with [3H]dihydrotetrabenazine.
Topics: Aging; Amines; Animals; Autoradiography; Binding Sites; Brain; Female; Male; Mesencephalon; Rats; Rats, Inbred Strains; Synaptic Vesicles; Telencephalon; Tetrabenazine; Tritium | 1990 |
Axonal transport of synaptic vesicles and muscarinic receptors: effect of protein synthesis inhibitors.
Topics: Animals; Anisomycin; Axons; Binding Sites; Biological Transport; Cycloheximide; Ligation; Male; Nerve Tissue Proteins; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Reserpine; Synaptic Vesicles; Tetrabenazine; Time Factors | 1990 |
Induction of the vesicular monoamine transporter by elevated potassium concentration in cultures of rat sympathetic neurons.
Topics: Animals; Biogenic Monoamines; Carrier Proteins; Cells, Cultured; Dopamine; Dopamine beta-Hydroxylase; Ganglia, Sympathetic; Potassium; Rats; Synaptic Vesicles; Tetrabenazine | 1990 |
Partial purification of dihydrotetrabenazine binding activity from bovine adrenal.
Topics: Adrenal Medulla; Animals; Cattle; Chromaffin Granules; Chromatography, Affinity; Solubility; Tetrabenazine | 1990 |
The regionalization of [3H]dihydrotetrabenazine binding sites in the mouse brain and its relationship to the distribution of monoamines and their metabolites.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Binding Sites; Biogenic Amines; Brain; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Mice; Nerve Tissue Proteins; Serotonin; Synaptic Vesicles; Tetrabenazine | 1986 |
Axonal transport of the synaptic vesicle monoamine carrier identified by [3H]dihydrotetrabenazine binding in rat sciatic nerve.
Topics: Animals; Axonal Transport; Binding Sites; Biological Transport, Active; Lipid Bilayers; Rats; Sciatic Nerve; Synaptic Vesicles; Tetrabenazine | 1987 |
Quantitative autoradiography of the rat brain vesicular monoamine transporter using the binding of [3H]dihydrotetrabenazine and 7-amino-8-[125I]iodoketanserin.
Topics: Animals; Biogenic Monoamines; Brain; In Vitro Techniques; Ketanserin; Male; Rats; Rats, Inbred Strains; Tetrabenazine | 1989 |
Interaction of dihydrotetrabenazine binding activity with immobilized lectins.
Topics: Adsorption; Animals; Cattle; Concanavalin A; Corpus Striatum; In Vitro Techniques; Lectins; Synaptosomes; Tetrabenazine; Wheat Germ Agglutinins | 1989 |
Striatal dopamine deficiency in Parkinson's disease: role of aging.
Topics: Aged; Aging; Corpus Striatum; Dopamine; Humans; Parkinson Disease, Secondary; Tetrabenazine | 1989 |
Dicyclohexylcarbodiimide inhibits the monoamine carrier of bovine chromaffin granule membrane.
Topics: Adenosine Triphosphatases; Amines; Binding, Competitive; Carbodiimides; Chromaffin Granules; Chromaffin System; Dicyclohexylcarbodiimide; Hydrogen-Ion Concentration; Intracellular Membranes; Kinetics; Reserpine; Serotonin; Tetrabenazine; Tyramine | 1985 |
D1 and D2-type dopamine receptors in patients with Parkinson's disease and progressive supranuclear palsy.
Topics: Adenylyl Cyclases; Adult; Aged; Benzazepines; Caudate Nucleus; Dopamine Antagonists; Humans; Middle Aged; Parkinson Disease; Putamen; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Reference Values; Spiperone; Supranuclear Palsy, Progressive; Tetrabenazine | 1988 |
Distribution of [3H]dihydrotetrabenazine binding in bovine striatal subsynaptic fractions: enrichment of higher affinity binding in a synaptic vesicle fraction.
Topics: Animals; Binding Sites; Cattle; Cell Membrane; Corpus Striatum; Ligands; Membrane Proteins; Subcellular Fractions; Synapses; Synaptic Vesicles; Synaptophysin; Tetrabenazine; Tissue Distribution; Tritium | 1988 |
Time required for transmitter accumulation inside monoaminergic storage vesicles differs in peripheral and in central systems.
Topics: Animals; Biogenic Monoamines; Brain; Carrier Proteins; Chromaffin Granules; Chromaffin System; Male; Peripheral Nerves; Rats; Rats, Inbred Strains; Reserpine; Subcellular Fractions; Synaptic Vesicles; Tetrabenazine | 1988 |
Characteristics of the transport of the quaternary ammonium 1-methyl-4-phenylpyridinium by chromaffin granules.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Binding Sites; Biological Transport, Active; Cattle; Chromaffin Granules; Chromaffin System; Hydrogen-Ion Concentration; Pyridinium Compounds; Reserpine; Serotonin; Tetrabenazine | 1988 |
[3H]dihydrotetrabenazine, a new in vitro monoaminergic probe for human brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Amines; Animals; Binding Sites; Brain; Corpus Striatum; Dopamine; Homovanillic Acid; Humans; Kinetics; Male; Postmortem Changes; Rats; Reserpine; Tetrabenazine; Tissue Distribution | 1988 |
Functional molecular mass of binding sites for [3H]dihydrotetrabenazine and [3H]reserpine and of dopamine beta-hydroxylase and cytochrome b561 from chromaffin granule membrane as determined by radiation inactivation.
Topics: Acetylcholinesterase; Animals; Binding Sites; Carrier Proteins; Cattle; Chromaffin Granules; Chromaffin System; Cytochrome b Group; Dopamine beta-Hydroxylase; Intracellular Membranes; Kinetics; Membrane Proteins; Reserpine; Tetrabenazine | 1987 |
Concentration-effect relationships of tetrabenazine and dihydrotetrabenazine in the rat.
Topics: Animals; Biogenic Amines; Brain; Brain Chemistry; Catecholamines; Dose-Response Relationship, Drug; Male; Rats; Rats, Inbred Strains; Receptors, Dopamine; Regression Analysis; Tetrabenazine | 1987 |
The pharmacokinetics of tetrabenazine and its hydroxy metabolite in patients treated for involuntary movement disorders.
Topics: Blood Proteins; Humans; Injections, Intravenous; Kinetics; Movement Disorders; Protein Binding; Tetrabenazine | 1986 |
Dihydrotetrabenazine binding and monoamine uptake in mouse brain regions.
Topics: Animals; Brain; Dopamine; Kinetics; Male; Mice; Norepinephrine; Serotonin; Subcellular Fractions; Synaptic Vesicles; Tetrabenazine; Tissue Distribution | 1986 |
[3H]Dihydrotetrabenazine binding to bovine striatal synaptic vesicles.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Biological Transport; Cattle; Corpus Striatum; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Reserpine; Synaptic Vesicles; Tetrabenazine; Tritium | 1986 |
Characterization of the vesicular monoamine transporter in cultured rat sympathetic neurons: persistence upon induction of cholinergic phenotypic traits.
Topics: Amines; Animals; Animals, Newborn; Carrier Proteins; Cells, Cultured; Cerebral Cortex; Chick Embryo; Choline O-Acetyltransferase; Chromaffin Granules; Electric Organ; Ganglia, Sympathetic; Kinetics; Neurons; Rats; Synaptic Vesicles; Tetrabenazine; Torpedo | 1987 |
Uptake of meta-iodobenzylguanidine by bovine chromaffin granule membranes.
Topics: 3-Iodobenzylguanidine; Adenosine Triphosphate; Adrenal Glands; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cattle; Cell Membrane; Chromaffin Granules; Chromaffin System; Hydrogen-Ion Concentration; In Vitro Techniques; Iodine Radioisotopes; Iodobenzenes; Kinetics; Norepinephrine; Radionuclide Imaging; Reserpine; Tetrabenazine | 1986 |
Characterization of the monoamine uptake system in catecholamine storage vesicles isolated from a pheochromocytoma taken from a child.
Topics: Adenosine Triphosphate; Adolescent; Adrenal Gland Neoplasms; Biogenic Amines; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Catecholamines; Chromaffin Granules; Chromaffin System; Female; Humans; In Vitro Techniques; Norepinephrine; Pheochromocytoma; Reserpine; Serotonin; Tetrabenazine | 1984 |
Characterization of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine.
Topics: Adrenal Medulla; Amines; Animals; Binding, Competitive; Cattle; Chromaffin Granules; Chromaffin System; Intracellular Membranes; Kinetics; Receptors, Serotonin; Tetrabenazine | 1983 |
Reserpine binding to bovine chromaffin granule membranes. Characterization and comparison with dihydrotetrabenazine binding.
Topics: Adrenal Medulla; Animals; Binding Sites; Cattle; Chromaffin Granules; Chromaffin System; Hydrogen-Ion Concentration; Intracellular Membranes; Kinetics; Reserpine; Tetrabenazine | 1984 |
[Binding of a tetrabenazine derivative to the monoamine transporter of the chromaffin granule membrane].
Topics: Adenosine Triphosphate; Binding Sites; Biogenic Amines; Biological Transport, Active; Chromaffin Granules; Chromaffin System; In Vitro Techniques; Membranes; Norepinephrine; Tetrabenazine | 1981 |
Acido-basic properties of the catecholamine uptake inhibitors tetrabenazine and dihydrotetrabenazine.
Topics: Catecholamines; Chromaffin System; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Norepinephrine; Solubility; Tetrabenazine | 1982 |
The catecholamine carrier of bovine chromaffin granules. Form of the bound amine.
Topics: Animals; Binding Sites; Carrier Proteins; Catecholamine Plasma Membrane Transport Proteins; Cattle; Chromaffin Granules; Chromaffin System; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Norepinephrine; Tetrabenazine | 1983 |
Solubilization of the catecholamine carrier of chromaffin granule membranes in a form that binds substrates and inhibitors of uptake.
Topics: Adrenal Medulla; Animals; Carrier Proteins; Catecholamine Plasma Membrane Transport Proteins; Catecholamines; Cattle; Chromaffin Granules; Chromaffin System; Detergents; Intracellular Membranes; Kinetics; Membrane Transport Proteins; Solubility; Tetrabenazine | 1983 |
Short-term treatments with haloperidol or bromocriptine do not alter the density of the monoamine vesicular transporter in the substantia nigra.
Topics: Animals; Autoradiography; Axonal Transport; Bromocriptine; Colchicine; Dopamine; Glycoproteins; Haloperidol; Male; Medial Forebrain Bundle; Membrane Glycoproteins; Membrane Transport Proteins; Microinjections; Neuropeptides; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Substantia Nigra; Synaptic Vesicles; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins | 1994 |
Binding of alpha-dihydrotetrabenazine to the vesicular monoamine transporter is stereospecific.
Topics: Animals; Brain; Carbon Radioisotopes; Drug Evaluation, Preclinical; Female; Glycoproteins; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Neuropeptides; Neurotransmitter Agents; Stereoisomerism; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1995 |
Long term stimulation changes the vesicular monoamine transporter content of chromaffin granules.
Topics: Animals; Biological Transport; Catecholamines; Cattle; Cell Fractionation; Cell Membrane Permeability; Cells, Cultured; Chromaffin Granules; Chromaffin System; Chromogranin A; Chromogranins; Cytochrome b Group; Exocytosis; Fluorescent Antibody Technique; Glycoproteins; Intracellular Membranes; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Norepinephrine; Potassium; Stimulation, Chemical; Tetrabenazine; Tyrosine 3-Monooxygenase; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1995 |
Autoradiographic distribution of the eye monoaminergic synaptic vesicles.
Topics: Aged; Animals; Autoradiography; Binding Sites; Biogenic Monoamines; Biological Transport; Eye; Glycoproteins; Humans; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Neurotransmitter Agents; Rabbits; Rats; Rats, Wistar; Synaptic Vesicles; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins | 1994 |
Monoamine vesicular uptake sites in patients with Parkinson's disease and Alzheimer's disease, as measured by tritiated dihydrotetrabenazine autoradiography.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autoradiography; Binding Sites; Biogenic Monoamines; Corpus Striatum; Female; Humans; Male; Middle Aged; Parkinson Disease; Reference Values; Tetrabenazine; Tritium | 1994 |
Dopamine denervation, age of onset, and Parkinson's disease.
Topics: Age of Onset; Aged; Caudate Nucleus; Denervation; Dopamine; Humans; Middle Aged; Parkinson Disease; Tetrabenazine; Tritium | 1995 |
Comparison of the subregional distributions of the monoamine vesicular transporter and dopamine uptake complex in the rat striatum and changes during aging.
Topics: Aging; Animals; Autoradiography; Citalopram; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Glycoproteins; Male; Membrane Glycoproteins; Membrane Proteins; Membrane Transport Proteins; Neostriatum; Nerve Tissue Proteins; Neuropeptides; Neurotransmitter Agents; Piperazines; Protein Binding; Rats; Rats, Wistar; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1994 |
The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat.
Topics: Animals; Binding, Competitive; Brain; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Rats; Self Administration; Tetrabenazine | 1996 |
Striatal concentrations of vesicular monoamine transporters are identical in MPTP-sensitive (C57BL/6) and -insensitive (CD-1) mouse strains.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Autoradiography; Binding Sites; Carbon Radioisotopes; Corpus Striatum; Female; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neuropeptides; Neurotransmitter Agents; Protein Binding; Radioactive Tracers; Radioligand Assay; Tetrabenazine; Tissue Distribution; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1996 |
Effects of dopaminergic drug treatments on in vivo radioligand binding to brain vesicular monoamine transporters.
Topics: Animals; Biological Transport; Brain; Carbon Radioisotopes; COS Cells; Dopamine Agents; Drug Interactions; Female; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Neuropeptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1996 |
Kinetic evaluation of [11C]dihydrotetrabenazine by dynamic PET: measurement of vesicular monoamine transporter.
Topics: Adult; Binding Sites; Biological Transport; Humans; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Models, Theoretical; Neuropeptides; Radioligand Assay; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1996 |
Presynaptic monoaminergic vesicles in Parkinson's disease and normal aging.
Topics: Adult; Aged; Aging; Animals; Biological Transport; Biomarkers; Blood-Brain Barrier; Cerebral Cortex; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Parkinson Disease; Presynaptic Terminals; Rats; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1996 |
Decreased striatal monoaminergic terminals in olivopontocerebellar atrophy and multiple system atrophy demonstrated with positron emission tomography.
Topics: Adult; Aged; Autonomic Nervous System Diseases; Basal Ganglia Diseases; Biological Transport; Cerebellar Diseases; Corpus Striatum; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Olivopontocerebellar Atrophies; Presynaptic Terminals; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1996 |
Time-dependent recovery of in vivo binding sites after drug dosing: a method for radiotracer evaluation.
Topics: Adrenergic Uptake Inhibitors; Animals; Binding Sites; Brain; Female; Injections, Intravenous; Mice; Radioligand Assay; Tetrabenazine; Time Factors | 1997 |
Reserpine affects differentially the density of the vesicular monoamine transporter and dihydrotetrabenazine binding sites.
Topics: Animals; Autoradiography; Binding Sites; Corpus Striatum; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Rats; Rats, Sprague-Dawley; Reserpine; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1996 |
A simple synthesis of [11C]dihydrotetrabenazine (DTBZ).
Topics: Carbon Radioisotopes; Hydrocarbons, Iodinated; Indicators and Reagents; Isotope Labeling; Molecular Structure; Tetrabenazine | 1997 |
Absolute configuration of (+)-alpha-dihydrotetrabenazine, an active metabolite of tetrabenazine.
Topics: Anti-Dyskinesia Agents; Chromatography, Liquid; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Molecular Structure; Stereoisomerism; Tetrabenazine | 1997 |
Striatal dopamine nerve terminal markers but not nigral cellularity are reduced in spinocerebellar ataxia type 1.
Topics: Adult; Biomarkers; Cadaver; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Endings; Nerve Tissue Proteins; Putamen; Spinocerebellar Degenerations; Substantia Nigra; Tetrabenazine | 1997 |
In vivo binding of (+)-alpha-[3H]dihydrotetrabenazine to the vesicular monoamine transporter of rat brain: bolus vs. equilibrium studies.
Topics: Animals; Brain Chemistry; Female; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1997 |
Equilibrium versus compartmental analysis for assessment of the vesicular monoamine transporter using (+)-alpha-[11C]dihydrotetrabenazine (DTBZ) and positron emission tomography.
Topics: Adult; Biological Transport; Brain; Humans; Injections, Intravenous; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1997 |
Imaging of monoaminergic and cholinergic vesicular transporters in the brain.
Topics: Acetylcholine; Alzheimer Disease; Brain; Carbon Radioisotopes; Carrier Proteins; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Neuromuscular Depolarizing Agents; Neurons; Neuropeptides; Neurotransmitter Agents; Parkinson Disease; Piperidines; Tetrabenazine; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Tritium; Vesicular Acetylcholine Transport Proteins; Vesicular Biogenic Amine Transport Proteins; Vesicular Transport Proteins | 1998 |
Reduced striatal vesicular monoamine transporters after neurotoxic but not after behaviorally-sensitizing doses of methamphetamine.
Topics: Animals; Autoradiography; Carrier Proteins; Central Nervous System Stimulants; Corpus Striatum; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Nerve Tissue Proteins; Neuropeptides; Protein Binding; Rats; Rats, Sprague-Dawley; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1997 |
High-efficiency expression and characterization of the synaptic-vesicle monoamine transporter from baculovirus-infected insect cells.
Topics: Animals; Baculoviridae; Biological Transport; Cattle; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Photochemistry; Rats; Spodoptera; Synaptic Vesicles; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1998 |
Regulation of rat brain vesicular monoamine transporter by chronic treatment with ovarian hormones.
Topics: Animals; Autoradiography; Dopamine; Estradiol; Female; Gene Expression; In Situ Hybridization; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Neurotransmitter Agents; Progesterone; Radioligand Assay; Rats; Rats, Inbred Strains; RNA, Messenger; Serotonin; Synaptophysin; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1998 |
Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine.
Topics: Animals; Binding, Competitive; Biological Transport; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Agents; Lobeline; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Neurotransmitter Agents; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1998 |
Transient expression of the vesicular monoamine transporter during development in the rat thalamus and cortex.
Topics: Animals; Animals, Newborn; Female; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Neurotransmitter Agents; Radiography; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tetrabenazine; Thalamus; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins; Visual Cortex | 1998 |
Decreased striatal monoaminergic terminals in severe chronic alcoholism demonstrated with (+)[11C]dihydrotetrabenazine and positron emission tomography.
Topics: Adult; Aged; Alcoholism; Biogenic Monoamines; Cohort Studies; Corpus Striatum; Humans; Injections, Intravenous; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Endings; Neuropeptides; Neurotransmitter Agents; Smoking; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1998 |
Quantitative comparison of three- and two-dimensional PET with human brain studies.
Topics: Adult; Aged; Benzazepines; Brain; Carbon Radioisotopes; Case-Control Studies; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Middle Aged; Radiopharmaceuticals; Tetrabenazine; Tomography, Emission-Computed | 1998 |
[125I]EGF binding in basal ganglia of patients with Parkinson's disease and progressive supranuclear palsy and in MPTP-treated monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Animals; Basal Ganglia; Brain Diseases; Dopamine Agents; Epidermal Growth Factor; ErbB Receptors; Female; Humans; Immunohistochemistry; Iodine Radioisotopes; Macaca fascicularis; Male; Parkinson Disease; Supranuclear Palsy, Progressive; Tetrabenazine | 1998 |
Reproducibility studies with 11C-DTBZ, a monoamine vesicular transporter inhibitor in healthy human subjects.
Topics: Adult; Aged; Brain; Carbon Radioisotopes; Cerebellum; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Neurotransmitter Agents; Occipital Lobe; Radiopharmaceuticals; Reproducibility of Results; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1999 |
(+)-alpha-[11C]Dihydrotetrabenazine PET imaging in familial paroxysmal dystonic choreoathetosis.
Topics: Adult; Aged; Athetosis; Binding Sites; Carbon Radioisotopes; Chorea; Dystonia; Humans; Kinetics; Male; Middle Aged; Tetrabenazine; Tomography, Emission-Computed | 1999 |
Decreased striatal monoaminergic terminals in multiple system atrophy detected with positron emission tomography.
Topics: Adult; Aged; Aged, 80 and over; Brain; Corpus Striatum; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multiple System Atrophy; Tetrabenazine; Tomography, Emission-Computed | 1999 |
Assessment of extrastriatal vesicular monoamine transporter binding site density using stereoisomers of [11C]dihydrotetrabenazine.
Topics: Adult; Binding Sites; Brain; Carbon Radioisotopes; Humans; Kinetics; Least-Squares Analysis; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Neurotransmitter Agents; Organ Specificity; Stereoisomerism; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 1999 |
Rapid and differential losses of in vivo dopamine transporter (DAT) and vesicular monoamine transporter (VMAT2) radioligand binding in MPTP-treated mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Carbon Radioisotopes; Carrier Proteins; Cerebellum; Cerebral Cortex; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Hippocampus; Hypothalamus; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuropeptides; Neurotransmitter Agents; Radioligand Assay; Tetrabenazine; Tissue Distribution; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
Reserpine or chronic paroxetine treatments do not modify the vesicular monoamine transporter 2 expression in serotonin-containing regions of the rat brain.
Topics: Animals; Autoradiography; Binding Sites; Biological Transport; Brain; Citalopram; Dopamine; Immunohistochemistry; In Situ Hybridization; In Vitro Techniques; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Norepinephrine; Paroxetine; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Reserpine; Selective Serotonin Reuptake Inhibitors; Serotonin; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease.
Topics: Aged; Carbon Radioisotopes; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Down-Regulation; Fluorine Radioisotopes; Homovanillic Acid; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Presynaptic Terminals; Tetrabenazine; Tomography, Emission-Computed | 2000 |
Analysis of four dopaminergic tracers kinetics using two different tissue input function methods.
Topics: Adult; Aged; Benzazepines; Carrier Proteins; Dopamine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Middle Aged; Models, Biological; Nerve Tissue Proteins; Neuropeptides; Raclopride; Receptors, Dopamine D1; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins | 2000 |
Analysis of VMAT2 binding after methamphetamine or MPTP treatment: disparity between homogenates and vesicle preparations.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dopamine Agents; Histological Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Mice; Neuropeptides; Synaptic Vesicles; Synaptosomes; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
Methamphetamine rapidly decreases vesicular dopamine uptake.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; Neurons; Neuropeptides; p-Chloroamphetamine; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Synaptic Vesicles; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
Decreased striatal monoaminergic terminals in Huntington disease.
Topics: Adult; Aged; Brain Mapping; Corpus Striatum; Female; Humans; Huntington Disease; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Neurotransmitter Agents; Predictive Value of Tests; Substantia Nigra; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
High vesicular monoamine transporter binding in asymptomatic bipolar I disorder: sex differences and cognitive correlates.
Topics: Adult; Biomarkers; Bipolar Disorder; Brain Stem; Cognition Disorders; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Presynaptic Terminals; Sex Factors; Tetrabenazine; Thalamus; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
Column-switching HPLC for the analysis of plasma in PET imaging studies.
Topics: Chromatography, High Pressure Liquid; Cocaine; Dopamine Agents; Imidazoles; Isoquinolines; Ligands; Pyridines; Raclopride; Sensitivity and Specificity; Solvents; Tetrabenazine; Time Factors; Tomography, Emission-Computed; Urea | 2000 |
In vivo measurement of the vesicular monoamine transporter in schizophrenia.
Topics: Adolescent; Adult; Binding Sites; Carbon Radioisotopes; Disease Progression; Dopamine; Female; Humans; Image Processing, Computer-Assisted; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neostriatum; Neuropeptides; Presynaptic Terminals; Radioligand Assay; Schizophrenia; Synaptic Vesicles; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2000 |
Decreased densities of dopamine and serotonin transporters and of vesicular monoamine transporter 2 in severely kainic acid lesioned subregions of the striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Carrier Proteins; Chromatography, High Pressure Liquid; Citalopram; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Excitatory Amino Acid Agonists; Homovanillic Acid; Hydroxyindoleacetic Acid; Kainic Acid; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neuropeptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
Cocaine-induced increases in vesicular dopamine uptake: role of dopamine receptors.
Topics: Animals; Benzazepines; Cocaine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neostriatum; Neuropeptides; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Synaptic Vesicles; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
Characterization of high-affinity [3H]TBZOH binding to the human platelet vesicular monoamine transporter.
Topics: Animals; Biological Transport; Blood Platelets; Cattle; Cell Membrane; Humans; Kinetics; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Protein Binding; Rats; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2001 |
In vivo measures of dopaminergic radioligands in the rat brain: equilibrium infusion studies.
Topics: Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Infusion Pumps; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Neurons; Neuropeptides; Radioligand Assay; Rats; Rats, Sprague-Dawley; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Methylenedioxymethamphetamine decreases plasmalemmal and vesicular dopamine transport: mechanisms and implications for neurotoxicity.
Topics: Animals; Biological Transport; Body Temperature; Cell Membrane; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Hallucinogens; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neuropeptides; Neurotoxins; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Phencyclidine increases vesicular dopamine uptake.
Topics: Animals; Binding, Competitive; Dizocilpine Maleate; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Salicylamides; Synaptic Vesicles; Tetrabenazine; Tritium | 2002 |
Chronic clozapine, but not haloperidol, treatment affects rat brain vesicular monoamine transporter 2.
Topics: Animals; Antipsychotic Agents; Binding Sites; Biological Transport; Brain; Brain Chemistry; Clozapine; Drug Administration Schedule; Fluoxetine; Haloperidol; In Situ Hybridization; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Paroxetine; Piperazines; Rats; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Increased platelet vesicular monoamine transporter density in adult schizophrenia patients.
Topics: Adult; Binding, Competitive; Blood Platelets; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Protein Binding; Schizophrenia; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Lack of effect of testosterone and dihydrotestosterone compared to 17beta-oestradiol in 1-methyl-4-phenyl-1,2,3,6, tetrahydropyridine-mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Autoradiography; Cocaine; Dihydrotestosterone; Dopamine; Dopamine Plasma Membrane Transport Proteins; Estradiol; Gonadal Steroid Hormones; Homovanillic Acid; In Situ Hybridization; Iodine Radioisotopes; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Tissue Proteins; Neuropeptides; RNA, Messenger; Testosterone; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Methylphenidate redistributes vesicular monoamine transporter-2: role of dopamine receptors.
Topics: Animals; Binding, Competitive; Blotting, Western; Corpus Striatum; Dopamine; Dopamine Agents; Dopamine Antagonists; Dose-Response Relationship, Drug; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Neuropeptides; Protein Transport; Rats; Receptors, Dopamine; Subcellular Fractions; Synaptosomes; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Elevated platelet vesicular monoamine transporter density in untreated patients diagnosed with major depression.
Topics: Adult; Aged; Blood Platelets; Brain; Depressive Disorder, Major; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Neuropeptides; Radioligand Assay; Recurrence; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2002 |
Decreased limbic vesicular monoamine transporter 2 in a genetic rat model of depression.
Topics: Animals; Depression; Disease Models, Animal; Limbic System; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
VMAT2 binding is elevated in dopa-responsive dystonia: visualizing empty vesicles by PET.
Topics: Adolescent; Adult; Carbon Radioisotopes; Corpus Striatum; Cytoplasmic Vesicles; Dopamine; Dopamine Agents; Dystonic Disorders; Female; Fluorine Radioisotopes; Humans; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Middle Aged; Neuropeptides; Parkinson Disease; Raclopride; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high-dose methamphetamine binge.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Binding Sites; Body Temperature; Brain Chemistry; Central Nervous System Stimulants; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Administration Schedule; Homovanillic Acid; Male; Methamphetamine; Motor Activity; Neostriatum; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Tetrabenazine; Time Factors; Tritium | 2003 |
Increased ventral striatal monoaminergic innervation in Tourette syndrome.
Topics: Adolescent; Adult; Binding, Competitive; Biogenic Monoamines; Body Fluid Compartments; Carbon Radioisotopes; Corpus Striatum; Female; Humans; Image Processing, Computer-Assisted; Ligands; Magnetic Resonance Imaging; Male; Membrane Glycoproteins; Membrane Transport Proteins; Middle Aged; Models, Biological; Neurons; Neuropeptides; Presynaptic Terminals; Reference Values; Tetrabenazine; Tomography, Emission-Computed; Tourette Syndrome; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
[11C]DTBZ-PET correlates of levodopa responses in asymmetric Parkinson's disease.
Topics: Aged; Antiparkinson Agents; Dopamine; Fingers; Humans; Image Processing, Computer-Assisted; Levodopa; Middle Aged; Movement; Parkinson Disease; Reaction Time; Synaptic Vesicles; Tetrabenazine; Tomography, Emission-Computed | 2003 |
Dopamine transmission in DYT1 dystonia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Autoradiography; Basal Ganglia; Benzamides; Benzazepines; Binding Sites; Carrier Proteins; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dystonia; Family Health; Homovanillic Acid; Humans; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Chaperones; Neuropeptides; Synaptic Transmission; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins | 2004 |
Apparent opposite effects of tetrabenazine and reserpine on the toxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine on nigro-striatal dopaminergic neurons.
Topics: 1-Methyl-4-phenylpyridinium; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Binding Sites; Body Temperature; Dopamine; Drug Administration Routes; Drug Interactions; Hypothalamus; Hypothermia; Male; Mazindol; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Neostriatum; Neurons; Neuropeptides; Neurotoxins; Oxidopamine; Reserpine; Substantia Nigra; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
Raclopride studies of dopamine release: dependence on presynaptic integrity.
Topics: Animals; Binding Sites; Brain; Carbon Radioisotopes; Dihydroxyphenylalanine; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Fluorine Radioisotopes; Macaca mulatta; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Raclopride; Radioligand Assay; Receptors, Dopamine D2; Tetrabenazine; Tomography, Emission-Computed; Vesicular Biogenic Amine Transport Proteins | 2003 |
Electrochemical monitoring of transport by a vesicular monoamine transporter expressed in Xenopus oocytes.
Topics: Animals; Binding Sites; Biological Transport; Dopamine; Electrochemistry; Environmental Monitoring; Enzyme Inhibitors; Gene Expression; Hydrogen-Ion Concentration; Membrane Glycoproteins; Membrane Transport Proteins; Microinjections; Mutation; Neuropeptides; Oocytes; Rats; RNA, Messenger; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins; Xenopus laevis | 2004 |
Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Brain; Brain Chemistry; Brain Mapping; Central Nervous System Stimulants; Chromatography, High Pressure Liquid; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Electrochemistry; Infusions, Intravenous; Macaca mulatta; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Radioligand Assay; ROC Curve; Self Administration; Serotonin Agents; Stereoisomerism; Tetrabenazine; Tissue Distribution; Tomography, Emission-Computed; Tritium | 2004 |
Striatal monoamine terminals in Lewy body dementia and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Binding Sites; Biogenic Monoamines; Carbon Isotopes; Corpus Striatum; Female; Humans; Lewy Body Disease; Male; Middle Aged; Neuropsychological Tests; Presynaptic Terminals; Tetrabenazine; Tomography, Emission-Computed | 2004 |
Long-term reproducibility of in vivo measures of specific binding of radioligands in rat brain.
Topics: Aging; Animals; Brain; Carbon Radioisotopes; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Female; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Sex Factors; Tetrabenazine; Time Factors; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2004 |
Identification of tissue-restricted transcripts in human islets.
Topics: Culture Techniques; Down-Regulation; Gene Expression Profiling; Humans; Interferon alpha-2; Interferon-alpha; Islets of Langerhans; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Oligonucleotide Array Sequence Analysis; Recombinant Proteins; RNA, Messenger; Tetrabenazine; Up-Regulation; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2004 |
Differential effects of scopolamine on in vivo binding of dopamine transporter and vesicular monoamine transporter radioligands in rat brain.
Topics: Animals; Binding, Competitive; Brain; Brain Chemistry; Dopamine Plasma Membrane Transport Proteins; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Muscarinic Antagonists; Nerve Tissue Proteins; Neuropeptides; Radioligand Assay; Rats; Scopolamine; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2004 |
Lack of regional selectivity during the progression of Parkinson disease: implications for pathogenesis.
Topics: Aged; Brain; Disease Progression; Dopamine; Female; Humans; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Protein Binding; Regression Analysis; Tetrabenazine | 2004 |
Decreased platelet vesicular monoamine transporter density in children and adolescents with attention deficit/hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Blood Platelets; Child; Gene Expression Regulation; Humans; Male; Membrane Glycoproteins; Membrane Transport Proteins; Protein Binding; Severity of Illness Index; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2005 |
Decreased platelet vesicular monoamine transporter density in habitual smokers.
Topics: Adult; Blood Platelets; Female; Humans; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Middle Aged; Protein Binding; Smoking; Tetrabenazine; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2005 |
The influence of measurement uncertainties on the evaluation of the distribution volume ratio and binding potential in rat studies on a microPET R4: a phantom study.
Topics: Affinity Labels; Animals; Carbon Isotopes; Corpus Striatum; Models, Animal; Phantoms, Imaging; Positron-Emission Tomography; Rats; Tetrabenazine; Tissue Distribution | 2005 |
11C-DTBZ and 18F-FDG PET measures in differentiating dementias.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbon Radioisotopes; Cerebral Cortex; Dementia; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Humans; Lewy Body Disease; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Regional Blood Flow; Regression Analysis; Tetrabenazine | 2005 |
PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.
Topics: Adult; Age Factors; Aged; Brain; Carbon Radioisotopes; Carboxy-Lyases; Case-Control Studies; Dopamine Plasma Membrane Transport Proteins; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Levodopa; Methylphenidate; Middle Aged; Mutation; Parkinson Disease; Phenotype; Positron-Emission Tomography; Protein Serine-Threonine Kinases; Radiopharmaceuticals; Receptors, Dopamine D2; Regression Analysis; Tetrabenazine | 2005 |
Platelet vesicular monoamine transporter density in untreated patients diagnosed with social phobia.
Topics: Adult; Blood Platelets; Cell Count; Female; Humans; Male; Phobic Disorders; Surveys and Questionnaires; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2005 |
Positron emission tomography of monoaminergic vesicular binding in aging and Parkinson disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Biogenic Monoamines; Female; Humans; Male; Middle Aged; Neostriatum; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Synaptic Vesicles; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2006 |
Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.
Topics: Animals; Blood Glucose; Carbon Radioisotopes; Diabetes Mellitus, Type 1; Disease Models, Animal; Humans; Insulin; Insulin-Secreting Cells; Male; Papio; Positron-Emission Tomography; Radioligand Assay; Rats; Rats, Inbred BB; Rats, Sprague-Dawley; Tetrabenazine; Tissue Distribution; Vesicular Monoamine Transport Proteins | 2006 |
Interaction of amphetamines and related compounds at the vesicular monoamine transporter.
Topics: Amphetamines; Animals; Caudate Nucleus; Dopamine; N-Methyl-3,4-methylenedioxyamphetamine; Piperazines; Rats; Tetrabenazine; Tyramine; Vesicular Monoamine Transport Proteins | 2006 |
Fluoroalkyl derivatives of dihydrotetrabenazine as positron emission tomography imaging agents targeting vesicular monoamine transporters.
Topics: Animals; Binding Sites; Fluorine Radioisotopes; Male; Mice; Mice, Inbred ICR; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2006 |
Visualizing pancreatic beta-cell mass with [11C]DTBZ.
Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Diabetes Mellitus, Experimental; Insulin-Secreting Cells; Pancreas; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Inbred Lew; Reproducibility of Results; Sensitivity and Specificity; Tetrabenazine | 2006 |
In vivo measurement of density and affinity of the monoamine vesicular transporter in a unilateral 6-hydroxydopamine rat model of PD.
Topics: Adrenergic Agents; Animals; Brain; Carbon Radioisotopes; Image Processing, Computer-Assisted; Male; Oxidopamine; Parkinsonian Disorders; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2007 |
Reduced platelet vesicular monoamine transporter density in Tourette's syndrome pediatric male patients.
Topics: Adolescent; Blood Platelets; Cell Membrane; Child; Humans; Ligands; Male; Radiopharmaceuticals; Tetrabenazine; Tourette Syndrome; Vesicular Monoamine Transport Proteins | 2007 |
Pharmacokinetics of [(18)F]fluoroalkyl derivatives of dihydrotetrabenazine in rat and monkey brain.
Topics: Animals; Brain; Fluorine Radioisotopes; Haplorhini; Metabolic Clearance Rate; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tetrabenazine; Tissue Distribution; Vesicular Monoamine Transport Proteins | 2007 |
Characterization of optically resolved 9-fluoropropyl-dihydrotetrabenazine as a potential PET imaging agent targeting vesicular monoamine transporters.
Topics: Animals; Brain; Feasibility Studies; Fluorine Radioisotopes; Male; Metabolic Clearance Rate; Mice; Mice, Inbred ICR; Organ Specificity; Positron-Emission Tomography; Radiopharmaceuticals; Stereoisomerism; Tetrabenazine; Tissue Distribution; Vesicular Monoamine Transport Proteins | 2007 |
VMAT2 and dopamine neuron loss in a primate model of Parkinson's disease.
Topics: Animals; Autoradiography; Brain; Carbon Isotopes; Carrier Proteins; Cocaine; Disease Models, Animal; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Glial Fibrillary Acidic Protein; Isoquinolines; Male; Neurons; Papio anubis; Parkinsonian Disorders; Positron-Emission Tomography; Raclopride; Tetrabenazine; Tyrosine 3-Monooxygenase; Vesicular Monoamine Transport Proteins | 2008 |
Whole body [11C]-dihydrotetrabenazine imaging of baboons: biodistribution and human radiation dosimetry estimates.
Topics: Animals; Calibration; Carbon Radioisotopes; Male; Models, Animal; Papio; Positron-Emission Tomography; Radiation Dosage; Tetrabenazine; Tissue Distribution; Whole-Body Irradiation | 2008 |
Dihydrotetrabenazine positron emission tomography imaging in early, untreated Parkinson's disease.
Topics: Adult; Aged; Corpus Striatum; Cross-Sectional Studies; Early Diagnosis; Female; Humans; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Protein Binding; Tetrabenazine | 2008 |
Striatal dopaminergic terminals in type 1 and type 2 alcoholics measured with [3H]dihydrotetrabenazine and human whole hemisphere autoradiography.
Topics: Adult; Alcoholism; Autoradiography; Caudate Nucleus; Corpus Striatum; Dominance, Cerebral; Female; Humans; Male; Middle Aged; Nucleus Accumbens; Putamen; Receptors, Dopamine D1; Receptors, Dopamine D2; Reference Values; Tetrabenazine; Tritium; Vesicular Monoamine Transport Proteins | 2008 |
In vivo imaging of beta-cell mass in rats using 18F-FP-(+)-DTBZ: a potential PET ligand for studying diabetes mellitus.
Topics: Animals; Diabetes Mellitus; Fluorine Radioisotopes; Insulin-Secreting Cells; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tetrabenazine; Tissue Distribution; Vesicular Monoamine Transport Proteins | 2008 |
Differentiating Alzheimer's disease from dementia with Lewy bodies and Parkinson's disease with (+)-[11C]dihydrotetrabenazine positron emission tomography.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Carbon Radioisotopes; Cerebrovascular Circulation; Diagnosis, Differential; Female; Humans; Lewy Body Disease; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Tetrabenazine | 2008 |
Dopamine modulating drugs influence striatal (+)-[11C]DTBZ binding in rats: VMAT2 binding is sensitive to changes in vesicular dopamine concentration.
Topics: Animals; Carbon Radioisotopes; Corpus Striatum; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Male; Protein Binding; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2008 |
Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists.
Topics: Alkylation; Animals; Diabetes Mellitus; Hypoglycemic Agents; Male; Molecular Structure; Pyridones; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2008 |
Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes.
Topics: 3-Iodobenzylguanidine; Adult; Aged; Aged, 80 and over; DNA Mutational Analysis; Family Health; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Isoleucine; Japan; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Male; Middle Aged; Mutation; Parkinsonian Disorders; Positron-Emission Tomography; Protein Serine-Threonine Kinases; Radiopharmaceuticals; Tetrabenazine; Tyrosine | 2009 |
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism.
Topics: Amphetamine; Animals; Cocaine; Corpus Striatum; Cyclohexanols; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Image Processing, Computer-Assisted; Macaca fascicularis; Male; Manganese; Parkinsonian Disorders; Positron-Emission Tomography; Substantia Nigra; Synaptic Transmission; Tetrabenazine; Tyrosine 3-Monooxygenase | 2008 |
Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?
Topics: Adult; Analysis of Variance; Brain Mapping; Central Nervous System Stimulants; Corpus Striatum; Female; Humans; Magnetic Resonance Imaging; Male; Methamphetamine; Middle Aged; Neurologic Examination; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Substance Withdrawal Syndrome; Tetrabenazine; Time Factors; Vesicular Monoamine Transport Proteins | 2008 |
PET demonstrates reduced dopamine transporter expression in PD with dyskinesias.
Topics: Caudate Nucleus; Dopamine Plasma Membrane Transport Proteins; Dyskinesias; Female; Humans; Logistic Models; Male; Methylphenidate; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Putamen; Radiopharmaceuticals; Tetrabenazine | 2009 |
Normal dopaminergic nigrostriatal innervation in SPG3A hereditary spastic paraplegia.
Topics: Adult; Biomarkers; Carbon Radioisotopes; Case-Control Studies; Dopamine; Female; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Membrane Proteins; Mutation; Positron-Emission Tomography; Radiopharmaceuticals; Spastic Paraplegia, Hereditary; Substantia Nigra; Tetrabenazine | 2008 |
Pancreatic imaging with 11C-dihydrotetrabenazine PET: a perspective.
Topics: Carbon Radioisotopes; Diabetes Mellitus, Type 1; Humans; Pancreas; Positron-Emission Tomography; Radiopharmaceuticals; Tetrabenazine | 2009 |
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls.
Topics: Adult; Carbon Radioisotopes; Diabetes Mellitus, Type 1; Female; Humans; Insulin-Secreting Cells; Kidney Cortex; Male; Pancreas; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Reference Values; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2009 |
Dyskinesia in Parkinson disease: back for the future?
Topics: Antiparkinson Agents; Dopamine Agents; Dyskinesias; Humans; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Synapses; Tetrabenazine | 2009 |
Asymmetric synthesis of tetrabenazine and dihydrotetrabenazine.
Topics: Catalysis; Palladium; Stereoisomerism; Substrate Specificity; Tetrabenazine | 2009 |
Striatal [11C]dihydrotetrabenazine and [11C]methylphenidate binding in Tourette syndrome.
Topics: Adolescent; Adult; Binding, Competitive; Carbon Radioisotopes; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Female; Humans; Male; Methylphenidate; Middle Aged; Positron-Emission Tomography; Presynaptic Terminals; Substantia Nigra; Tetrabenazine; Tourette Syndrome; Vesicular Monoamine Transport Proteins; Young Adult | 2009 |
Visualizing vesicular dopamine dynamics in Parkinson's disease.
Topics: Antiparkinson Agents; Brain Mapping; Carbon Radioisotopes; Dopamine; Female; Humans; Levodopa; Male; Middle Aged; Nonlinear Dynamics; Parkinson Disease; Positron-Emission Tomography; Tetrabenazine | 2009 |
Signal separation and parameter estimation in noninvasive dual-tracer PET scans using reference-region approaches.
Topics: Carbon Radioisotopes; Flumazenil; Humans; Methods; Positron-Emission Tomography; Tetrabenazine | 2009 |
New MRI, 18F-DOPA and 11C-(+)-alpha-dihydrotetrabenazine templates for Macaca fascicularis neuroimaging: advantages to improve PET quantification.
Topics: Animals; Brain; Carbon Radioisotopes; Dihydroxyphenylalanine; Image Enhancement; Macaca fascicularis; Magnetic Resonance Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Reference Values; Subtraction Technique; Tetrabenazine | 2009 |
Measurement of plasmalemmal dopamine transport, vesicular dopamine transport, and K(+)-stimulated dopamine release in frozen rat brain tissue.
Topics: Animals; Body Temperature; Brain; Cell Membrane; Cryopreservation; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electrochemical Techniques; Male; Neurochemistry; Postmortem Changes; Potassium Compounds; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Tetrabenazine; Transport Vesicles; Vesicular Monoamine Transport Proteins | 2009 |
Synthesis and evaluation of 2-amino-dihydrotetrabenzine derivatives as probes for imaging vesicular monoamine transporter-2.
Topics: Animals; Iodine Radioisotopes; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Structure-Activity Relationship; Tetrabenazine; Tritium; Vesicular Monoamine Transport Proteins | 2009 |
Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
Topics: Binding Sites; Lobeline; Protein Binding; Pyrrolidines; Structure-Activity Relationship; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2009 |
Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter.
Topics: Animals; Blood Platelets; Cell Line; Hallucinogens; Humans; N,N-Dimethyltryptamine; Paroxetine; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Spodoptera; Tetrabenazine; Tritium; Tryptamines; Vesicular Monoamine Transport Proteins | 2009 |
The utility of [(11)C] dihydrotetrabenazine positron emission tomography scanning in assessing beta-cell performance after sleeve gastrectomy and duodenal-jejunal bypass.
Topics: Animals; Bariatric Surgery; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Duodenum; Gastrectomy; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Insulin-Secreting Cells; Jejunum; Positron-Emission Tomography; Rats; Rats, Inbred Strains; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2010 |
Dopamine transporter PET in normal aging: dopamine transporter decline and its possible role in preservation of motor function.
Topics: Adult; Aged; Aging; Brain; Carbon Radioisotopes; Caudate Nucleus; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Male; Methylphenidate; Middle Aged; Motor Activity; Neuropsychological Tests; Positron-Emission Tomography; Putamen; Tetrabenazine | 2010 |
In vivo [11C]dihydrotetrabenazine binding in rat striatum: sensitivity to dopamine concentrations.
Topics: alpha-Methyltyrosine; Animals; Carbon Radioisotopes; Dopamine; Male; Neostriatum; Protein Binding; Rats; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2010 |
Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans.
Topics: Administration, Oral; Adult; Amphetamine; Amphetamine-Related Disorders; Binding, Competitive; Central Nervous System Stimulants; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Female; Humans; Male; Positron-Emission Tomography; Prospective Studies; Tetrabenazine; Vesicular Monoamine Transport Proteins; Young Adult | 2010 |
A concise total synthesis of (+)-tetrabenazine and (+)-α-dihydrotetrabenazine.
Topics: Cholera; Huntington Disease; Molecular Structure; Stereoisomerism; Tetrabenazine | 2010 |
Progression of dopaminergic depletion in a model of MPTP-induced Parkinsonism in non-human primates. An (18)F-DOPA and (11)C-DTBZ PET study.
Topics: Animals; Brain Mapping; Carbon Radioisotopes; Caudate Nucleus; Corpus Striatum; Disease Models, Animal; Disease Progression; Dopamine; Dyskinesias; Female; Macaca fascicularis; Male; Parkinsonian Disorders; Positron-Emission Tomography; Putamen; Severity of Illness Index; Signal Processing, Computer-Assisted; Tetrabenazine | 2010 |
Comparing fludeoxyglucose F18-PET assessment of regional cerebral glucose metabolism and [11C]dihydrotetrabenazine-PET in evaluation of early dementia and mild cognitive impairment.
Topics: Age of Onset; Aged; Aged, 80 and over; Binding, Competitive; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Circulation; Cognition Disorders; Dementia; Early Diagnosis; Energy Metabolism; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Sensitivity and Specificity; Tetrabenazine | 2010 |
The effect of chronic methylphenidate administration on presynaptic dopaminergic parameters in a rat model for ADHD.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Binding Sites; Brain; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Male; Methylphenidate; Piperazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Dopamine; Synaptosomes; Tetrabenazine; Time Factors; Vesicular Monoamine Transport Proteins | 2010 |
11C-dihydrotetrabenazine beta-cell imaging.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Humans; Insulin-Secreting Cells; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2010 |
Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas.
Topics: Animals; Autoradiography; Binding, Competitive; Cattle; Diabetes Mellitus; Female; Humans; Islets of Langerhans; Male; Middle Aged; Organ Specificity; Protein Binding; Radioactive Tracers; Rats; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2010 |
Rat pancreas uptake of [11C]dihydrotetrabenazine stereoisomers.
Topics: Animals; Carbon Radioisotopes; Male; Pancreas; Rats; Stereoisomerism; Substrate Specificity; Tetrabenazine | 2010 |
Age-specific progression of nigrostriatal dysfunction in Parkinson's disease.
Topics: Adult; Aged; Aging; Carbon Isotopes; Corpus Striatum; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Longitudinal Studies; Male; Methylphenidate; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Protein Binding; Substantia Nigra; Tetrabenazine; Tritium; Young Adult | 2011 |
Preparation and evaluation of tetrabenazine enantiomers and all eight stereoisomers of dihydrotetrabenazine as VMAT2 inhibitors.
Topics: Animals; Male; Molecular Conformation; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2011 |
Synthesis and biological evaluation of 3-alkyl-dihydrotetrabenazine derivatives as vesicular monoamine transporter-2 (VMAT2) ligands.
Topics: Animals; Corpus Striatum; Crystallography, X-Ray; Diagnostic Imaging; Fluorine Radioisotopes; Ligands; Molecular Structure; Positron-Emission Tomography; Rats; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2011 |
Assessment of mild dementia with amyloid and dopamine terminal positron emission tomography.
Topics: Amyloid; Analysis of Variance; Aniline Compounds; Benzothiazoles; Brain Mapping; Carbon Isotopes; Dementia; Dopamine; Humans; Neurologic Examination; Positron-Emission Tomography; Psychiatric Status Rating Scales; Tetrabenazine; Thiazoles | 2011 |
Leucoaraiosis, nigrostriatal denervation and motor symptoms in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Carbon Isotopes; Corpus Striatum; Denervation; Female; Humans; Leukoaraiosis; Male; Middle Aged; Motor Activity; Parkinson Disease; Positron-Emission Tomography; Regression Analysis; Substantia Nigra; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2011 |
Platelet vesicular monoamine transporter 2 density in the disruptive behavior disorders.
Topics: Adolescent; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; Blood Platelets; Child; Comorbidity; Female; Humans; Male; Psychiatric Status Rating Scales; Radioligand Assay; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2011 |
Sigma receptor binding of tetrabenazine series tracers targeting VMAT2 in rat pancreas.
Topics: Animals; Binding, Competitive; Fluorine Radioisotopes; Guanidines; Male; Neostriatum; Pancrelipase; Protein Binding; Radioactive Tracers; Rats; Rats, Sprague-Dawley; Receptors, sigma; Substrate Specificity; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2011 |
DJ-1 and αSYN in LRRK2 CSF do not correlate with striatal dopaminergic function.
Topics: alpha-Synuclein; Biomarkers; Carbon Isotopes; Corpus Striatum; Dopamine; Female; Fluorodeoxyglucose F18; Humans; Intracellular Signaling Peptides and Proteins; Japan; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Luria-Nebraska Neuropsychological Battery; Male; Methylphenidate; Norway; Oncogene Proteins; Parkinson Disease; Positron-Emission Tomography; Protein Deglycase DJ-1; Protein Serine-Threonine Kinases; Statistics as Topic; Tetrabenazine; United States | 2012 |
A concise synthesis of tetrabenazine: an intramolecular aza-Prins-type cyclization via oxidative C-H activation.
Topics: Cyclization; Molecular Structure; Oxidation-Reduction; Silanes; Tetrabenazine | 2011 |
In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers.
Topics: Adult; Case-Control Studies; Cocaine-Related Disorders; Corpus Striatum; Female; Humans; Male; Positron-Emission Tomography; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2012 |
Heterogeneity of cholinergic denervation in Parkinson's disease without dementia.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Carbon Radioisotopes; Cognition; Corpus Striatum; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Motor Activity; Neocortex; Parkinson Disease; Positron-Emission Tomography; Propionates; Tetrabenazine; Thalamus | 2012 |
A ring-closing metathesis-based approach to the synthesis of (+)-tetrabenazine.
Topics: Amines; Cyclization; Lactams, Macrocyclic; Molecular Structure; Stereoisomerism; Tetrabenazine | 2012 |
β-Cell mass imaging with DTBZ positron emission tomography: is it possible?
Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Insulin-Secreting Cells; Molecular Imaging; Pancreas; Positron-Emission Tomography; Rats; Tetrabenazine | 2013 |
β-Amyloid and postural instability and gait difficulty in Parkinson's disease at risk for dementia.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Aniline Compounds; Carbon Isotopes; Cross-Sectional Studies; Dementia; Female; Gait Disorders, Neurologic; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Postural Balance; Psychiatric Status Rating Scales; Sensation Disorders; Severity of Illness Index; Tetrabenazine; Thiazoles | 2013 |
Validation of nigrostriatal positron emission tomography measures: critical limits.
Topics: Animals; Cocaine; Corpus Striatum; Disease Models, Animal; Fluorodeoxyglucose F18; Macaca mulatta; Magnetic Resonance Imaging; Male; MPTP Poisoning; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Reproducibility of Results; Substantia Nigra; Tetrabenazine | 2013 |
Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry.
Topics: Acetylcysteine; Analysis of Variance; Animals; Carbon Isotopes; Cell Count; Corpus Striatum; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Hindlimb; Locomotion; Movement Disorders; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tetrabenazine; Time Factors; Tyrosine 3-Monooxygenase | 2013 |
Assessing mild cognitive impairment with amyloid and dopamine terminal molecular imaging.
Topics: Aged; Amyloid; Aniline Compounds; Benzothiazoles; Cognitive Dysfunction; Cohort Studies; Dopamine; Female; Follow-Up Studies; Humans; Male; Positron-Emission Tomography; Prognosis; Tetrabenazine; Thiazoles | 2013 |
Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).
Topics: Animals; Binding Sites; Dopamine; Lobeline; Protein Binding; Pyrrolidines; Rats; Synaptic Vesicles; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2013 |
Validation of midbrain positron emission tomography measures for nigrostriatal neurons in macaques.
Topics: Animals; Carbon Isotopes; Disease Models, Animal; Fluorodeoxyglucose F18; Macaca mulatta; Magnetic Resonance Imaging; Male; Mesencephalon; MPTP Poisoning; Neurons; Positron-Emission Tomography; Substantia Nigra; Tetrabenazine | 2013 |
The pattern of striatal dopaminergic denervation explains sensorimotor synchronization accuracy in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Carbon Isotopes; Cluster Analysis; Corpus Striatum; Dopamine; Female; Humans; Levodopa; Male; Middle Aged; Motor Activity; Parkinson Disease; Positron-Emission Tomography; Psychomotor Performance; Tetrabenazine; Time Factors; Time Perception | 2013 |
Gait speed in Parkinson disease correlates with cholinergic degeneration.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Analysis of Variance; Carbon Isotopes; Cerebral Cortex; Cognition Disorders; Cross-Sectional Studies; Dioxolanes; Female; Gait Disorders, Neurologic; Humans; Male; Middle Aged; Nerve Degeneration; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2013 |
Synthesis and biological evaluation of 10-(11) C-dihydrotetrabenazine as a vesicular monoamine transporter 2 radioligand.
Topics: Animals; Brain Diseases; Carbon Radioisotopes; Cerebellum; Corpus Striatum; Molecular Structure; Oxidopamine; Positron-Emission Tomography; Protein Binding; Radioligand Assay; Radiopharmaceuticals; Rats; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2014 |
Modifiable cardiovascular risk factors and axial motor impairments in Parkinson disease.
Topics: Aged; Body Mass Index; Carbon Radioisotopes; Cardiovascular Diseases; Cross-Sectional Studies; Disability Evaluation; Female; Humans; Imaging, Three-Dimensional; Leukoaraiosis; Male; Middle Aged; Movement; Neuropsychological Tests; Parkinson Disease; Radionuclide Imaging; Reference Values; Rhombencephalon; Risk Factors; Severity of Illness Index; Tetrabenazine | 2014 |
Correlation of Parkinson disease severity and 18F-DTBZ positron emission tomography.
Topics: Adult; Aged; Female; Fluorine Radioisotopes; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Muscle Rigidity; Parkinson Disease; Positron-Emission Tomography; Tetrabenazine; Tremor | 2014 |
In vivo dopaminergic and serotonergic dysfunction in DCTN1 gene mutation carriers.
Topics: Adult; Aniline Compounds; Corpus Striatum; Depression; Dopamine; Dynactin Complex; Fluorine Radioisotopes; Humans; Hypoventilation; Microtubule-Associated Proteins; Middle Aged; Mutation; Parkinsonian Disorders; Positron-Emission Tomography; Raclopride; Serotonin; Sulfides; Tetrabenazine; Tomography, Emission-Computed | 2014 |
Extra-nigral pathological conditions are common in Parkinson's disease with freezing of gait: an in vivo positron emission tomography study.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Carbon Isotopes; Cross-Sectional Studies; Female; Freezing Reaction, Cataleptic; Gait Disorders, Neurologic; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Substantia Nigra; Tetrabenazine; Thiazoles; Vesicular Monoamine Transport Proteins | 2014 |
Is Parkinson's disease a vesicular dopamine storage disorder? Evidence from a study in isolated synaptic vesicles of human and nonhuman primate striatum.
Topics: Aged; Aged, 80 and over; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Uptake Inhibitors; Female; Homovanillic Acid; Humans; Macaca fascicularis; Male; MPTP Poisoning; Parkinson Disease; Synaptic Vesicles; Tetrabenazine; Tritium; Vesicular Monoamine Transport Proteins | 2014 |
Decreased vesicular monoamine transporter type 2 availability in the striatum following chronic cocaine self-administration in nonhuman primates.
Topics: Aging; Animals; Brain; Carbon Isotopes; Cocaine; Cocaine-Related Disorders; Corpus Striatum; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Positron-Emission Tomography; Radiopharmaceuticals; Self Administration; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2015 |
Abnormal MoCA and normal range MMSE scores in Parkinson disease without dementia: cognitive and neurochemical correlates.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Brain; Cognition Disorders; Female; Guanidines; Humans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2014 |
A familial form of parkinsonism, dementia, and motor neuron disease: a longitudinal study.
Topics: Aged; Aged, 80 and over; C9orf72 Protein; Dementia; Family Health; Female; Humans; Intercellular Signaling Peptides and Proteins; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Longitudinal Studies; Male; Middle Aged; Motor Neuron Disease; Mutation; Parkinsonian Disorders; Positron-Emission Tomography; Progranulins; Protein Serine-Threonine Kinases; Proteins; Psychiatric Status Rating Scales; Severity of Illness Index; tau Proteins; Technetium Tc 99m Exametazime; Tetrabenazine; Tomography, Emission-Computed, Single-Photon | 2014 |
Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism.
Topics: Aged; Aged, 80 and over; Brain; Carbon Isotopes; Dopamine Agents; Family Health; Fluorodeoxyglucose F18; Humans; Levodopa; Middle Aged; Molecular Chaperones; Mutation; Parkinsonian Disorders; Positron-Emission Tomography; Tetrabenazine | 2014 |
Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease.
Topics: Aged; Butyrates; Carbon Isotopes; Cognition Disorders; Cross-Sectional Studies; Diabetes Complications; Diabetes Mellitus; Female; Humans; Male; Middle Aged; Neuroimaging; Neuropsychological Tests; Parkinson Disease; Piperidines; Positron-Emission Tomography; Severity of Illness Index; Tetrabenazine | 2014 |
Derivatization of (±) dihydrotetrabenazine for copper-64 labeling towards long-lived radiotracers for PET imaging of the vesicular monoamine transporter 2.
Topics: Animals; Brain; Copper Radioisotopes; Diagnostic Imaging; Insulin-Secreting Cells; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Swine; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2014 |
Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study.
Topics: Adrenergic Agents; Animals; Apomorphine; Brain; Carbon Radioisotopes; Disease Models, Animal; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Functional Laterality; Longitudinal Studies; Magnetic Resonance Imaging; Oxidopamine; Parkinson Disease; Positron-Emission Tomography; Protein Binding; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Tetrabenazine | 2015 |
Lessons from 11C-dihydrotetrabenazine imaging in a xenograft mouse model of rat insulinoma: is PET imaging of pancreatic beta cell mass feasible?
Topics: Animals; Carbon Radioisotopes; Cell Line, Tumor; Fluorodeoxyglucose F18; Heterografts; Insulinoma; Male; Mice; Mice, Inbred BALB C; Pancreatic Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Wistar; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2017 |
Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
Topics: Amphetamine-Related Disorders; Animals; Binding Sites; Dopamine; Humans; In Vitro Techniques; Kinetics; Lobeline; Methamphetamine; Rats; Structure-Activity Relationship; Synaptic Vesicles; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2015 |
Rapid Recovery of Vesicular Dopamine Levels in Methamphetamine Users in Early Abstinence.
Topics: Adult; Amphetamine-Related Disorders; Carbon Radioisotopes; Cocaine; Cognition Disorders; Corpus Striatum; Dopamine; Female; Humans; Male; Methamphetamine; Positron-Emission Tomography; Synaptic Vesicles; Tetrabenazine; Young Adult | 2016 |
Striatal and Cortical β-Amyloidopathy and Cognition in Parkinson's Disease.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Carbon Isotopes; Cerebral Cortex; Cognition Disorders; Corpus Striatum; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Tetrabenazine; Thiazoles | 2016 |
Diabetes, Gray Matter Loss, and Cognition in the Setting of Parkinson Disease.
Topics: Aged; Atrophy; Attention; Basal Ganglia; Brain Diseases; Carbon Radioisotopes; Case-Control Studies; Cognition; Cross-Sectional Studies; Diabetes Complications; Dopaminergic Neurons; Executive Function; Female; Frontal Lobe; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neurodegenerative Diseases; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Tetrabenazine | 2016 |
Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules.
Topics: Animals; Cell Line; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Carriers; Insulin-Secreting Cells; Kidney; Liver; Mice; Mice, Inbred BALB C; Pancreas; Pyridazines; Rabbits; Tandem Mass Spectrometry; Tetrabenazine; Tissue Distribution; Vesicular Monoamine Transport Proteins | 2016 |
In vitro enantioselective human liver microsomal metabolism and prediction of in vivo pharmacokinetic parameters of tetrabenazine by DLLME-CE.
Topics: Cytochrome P-450 CYP2C19; Drug Stability; Electrophoresis, Capillary; Humans; In Vitro Techniques; Liquid Phase Microextraction; Microsomes, Liver; Reproducibility of Results; Stereoisomerism; Tetrabenazine | 2016 |
A Novel Potential Positron Emission Tomography Imaging Agent for Vesicular Monoamine Transporter Type 2.
Topics: Animals; Brain; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Male; Molecular Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2016 |
Increased striatal VMAT2 binding in mice after chronic administration of methcathinone and manganese.
Topics: Animals; Autoradiography; Biomechanical Phenomena; Carbon Radioisotopes; Central Nervous System Stimulants; Corpus Striatum; Disease Models, Animal; Gait; Illicit Drugs; Injections, Intraperitoneal; Male; Manganese; Mice, Inbred C57BL; Motor Activity; Positron-Emission Tomography; Propiophenones; Psychotropic Drugs; Radiopharmaceuticals; Random Allocation; Substance-Related Disorders; Tetrabenazine; Time Factors; Vesicular Monoamine Transport Proteins | 2016 |
Neuroimaging and clinical features in adults with a 22q11.2 deletion at risk of Parkinson's disease.
Topics: Adult; Carbon Radioisotopes; Case-Control Studies; Corpus Striatum; DiGeorge Syndrome; Female; Functional Neuroimaging; Humans; Hypertrophy; Male; Parkinson Disease, Secondary; Positron-Emission Tomography; Substantia Nigra; Tetrabenazine; Ultrasonography, Doppler, Transcranial | 2017 |
Mentally stimulating activities associate with better cognitive performance in Parkinson disease.
Topics: Aged; Aged, 80 and over; Carbon Isotopes; Cognition Disorders; Cognitive Behavioral Therapy; Female; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Parkinson Disease; Phosphinic Acids; Piperidines; Positron-Emission Tomography; Regression Analysis; Tetrabenazine | 2017 |
Early synaptic dysfunction induced by α-synuclein in a rat model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Carbon Radioisotopes; Corpus Striatum; Disease Models, Animal; Dopaminergic Neurons; Humans; Parkinson Disease; Positron-Emission Tomography; Presynaptic Terminals; Rats; Rats, Transgenic; Substantia Nigra; Synapses; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2017 |
Differences in Dihydrotetrabenazine Isomer Concentrations Following Administration of Tetrabenazine and Valbenazine.
Topics: Adrenergic Uptake Inhibitors; Adult; Chromatography, Liquid; Female; Humans; Huntington Disease; Isomerism; Male; Middle Aged; Tandem Mass Spectrometry; Tardive Dyskinesia; Tetrabenazine; Valine | 2017 |
Reference tissue models in the assessment of
Topics: Adrenergic Uptake Inhibitors; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Female; Linear Models; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Rats, Wistar; Reproducibility of Results; Tetrabenazine; Tissue Distribution; Vesicular Monoamine Transport Proteins | 2018 |
Typical features of Parkinson disease and diagnostic challenges with microdeletion 22q11.2.
Topics: Adult; Antiparkinson Agents; Databases, Bibliographic; Deep Brain Stimulation; DiGeorge Syndrome; Female; Humans; International Cooperation; Male; Middle Aged; Parkinson Disease; Severity of Illness Index; Sex Distribution; Statistics, Nonparametric; Tetrabenazine; Tomography, Emission-Computed, Single-Photon | 2018 |
Quantitative study of
Topics: Aged; Brain; Case-Control Studies; Female; Fluorine Radioisotopes; Functional Neuroimaging; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Tetrabenazine | 2018 |
Diagnostic Utility of [11C]DTBZ Positron Emission Tomography In Clinically Uncertain Parkinsonism: Experience of a Single Tertiary Center.
Topics: Adult; Aged; Brain; Carbon Radioisotopes; Female; Humans; Male; Mexico; Middle Aged; Parkinson Disease; Parkinsonian Disorders; Predictive Value of Tests; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Tetrabenazine; Tomography, Emission-Computed, Single-Photon | 2018 |
Multimodal dopaminergic and free-water imaging in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Brain; Dopamine; Female; Humans; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Tetrabenazine; Tremor; Water | 2019 |
Maturation of the human striatal dopamine system revealed by PET and quantitative MRI.
Topics: Adolescent; Adult; Age Factors; Child; Cognitive Neuroscience; Corpus Striatum; Dopamine; Female; Humans; Kinetics; Magnetic Resonance Imaging; Male; Models, Biological; Neuroimaging; Positron-Emission Tomography; Raclopride; Receptors, Dopamine D2; Receptors, Dopamine D3; Tetrabenazine; Young Adult | 2020 |
[11C]dihydrotetrabenazine Positron Emission Tomography in Manganese-Exposed Workers.
Topics: Adult; Aged; Carbon Radioisotopes; Female; Humans; Male; Manganese; Middle Aged; Occupational Diseases; Occupational Exposure; Parkinsonian Disorders; Positron-Emission Tomography; Tetrabenazine; Young Adult | 2020 |
Dopaminergic Nigrostriatal Connectivity in Early Parkinson Disease: In Vivo Neuroimaging Study of
Topics: Carbon Radioisotopes; Diffusion Tensor Imaging; Dopamine; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Multimodal Imaging; Neostriatum; Parkinson Disease; Positron-Emission Tomography; Tetrabenazine | 2021 |
Synthesis and analysis of dihydrotetrabenazine derivatives as novel vesicular monoamine transporter 2 inhibitors.
Topics: Animals; Humans; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2021 |
9-Cyclopropylmethoxy-dihydrotetrabenazine and its stereoisomers as vesicular monoamine transporter-2 inhibitors.
Topics: Animals; Membrane Transport Modulators; Molecular Docking Simulation; Rats; Stereoisomerism; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2022 |
Pharmacokinetic and Pharmacologic Characterization of the Dihydrotetrabenazine Isomers of Deutetrabenazine and Valbenazine.
Topics: Cross-Over Studies; Dopamine; Humans; Serotonin; Tetrabenazine; Vesicular Monoamine Transport Proteins | 2023 |