Compounds > dihydrotetrabenazine
Page last updated: 2024-09-03

dihydrotetrabenazine and lobeline

dihydrotetrabenazine has been researched along with lobeline in 5 studies

Compound Research Comparison

Studies
(dihydrotetrabenazine)		Trials
(dihydrotetrabenazine)		Recent Studies (post-2010)
(dihydrotetrabenazine)		Studies
(lobeline)		Trials
(lobeline)		Recent Studies (post-2010) (lobeline)
23446024016
2344604952068

Protein Interaction Comparison

ProteinTaxonomydihydrotetrabenazine (IC50)lobeline (IC50)
Synaptic vesicular amine transporterHomo sapiens (human)4.2

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Eshleman, AJ; Gonzalez, M; Janowsky, A; Johnson, RA; Kryatova, O; Meltzer, PC; Nelson, J; Provencher, BA; Shi, X; Tian, J1
Crooks, PA; Dwoskin, LP; Teng, L1
Chagkutip, J; Crooks, PA; Dwoskin, LP; Nickell, JR; Vartak, AP1
Crooks, PA; Deaciuc, AG; Dwoskin, LP; Nickell, JR; Penthala, NR; Ponugoti, PR1
Crooks, PA; Ding, D; Dwoskin, LP; Nickell, JR1

Other Studies

5 other study(ies) available for dihydrotetrabenazine and lobeline

ArticleYear
Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter.
    Journal of medicinal chemistry, 2018, 10-25, Volume: 61, Issue:20

    Topics: Animals; Chemistry Techniques, Synthetic; Drug Design; HEK293 Cells; Humans; Ligands; Mice; Quinazolines; Vesicular Monoamine Transport Proteins

2018
Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: Animals; Binding, Competitive; Biological Transport; Corpus Striatum; Dextroamphetamine; Dopamine; Dopamine Agents; Lobeline; Male; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Neurotransmitter Agents; Nicotinic Agonists; Rats; Rats, Sprague-Dawley; Synaptic Vesicles; Tetrabenazine; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins

1998
Pyrrolidine analogues of lobelane: relationship of affinity for the dihydrotetrabenazine binding site with function of the vesicular monoamine transporter 2 (VMAT2).
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: Binding Sites; Lobeline; Protein Binding; Pyrrolidines; Structure-Activity Relationship; Tetrabenazine; Vesicular Monoamine Transport Proteins

2009
Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).
    Bioorganic & medicinal chemistry letters, 2013, Jun-01, Volume: 23, Issue:11

    Topics: Animals; Binding Sites; Dopamine; Lobeline; Protein Binding; Pyrrolidines; Rats; Synaptic Vesicles; Tetrabenazine; Vesicular Monoamine Transport Proteins

2013
Quinolyl analogues of norlobelane: novel potent inhibitors of [(3)H]dihydrotetrabenazine binding and [(3)H]dopamine uptake at the vesicular monoamine transporter-2.
    Bioorganic & medicinal chemistry letters, 2015, Jul-01, Volume: 25, Issue:13

    Topics: Amphetamine-Related Disorders; Animals; Binding Sites; Dopamine; Humans; In Vitro Techniques; Kinetics; Lobeline; Methamphetamine; Rats; Structure-Activity Relationship; Synaptic Vesicles; Tetrabenazine; Vesicular Monoamine Transport Proteins

2015