dihydromorphine has been researched along with morphinone* in 2 studies
2 other study(ies) available for dihydromorphine and morphinone
| Article | Year |
|---|---|
Method for determination of morphinone in urine and bile of guinea pig by high-performance liquid chromatography.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Dihydromorphine; Guinea Pigs; Hydromorphone; Mercaptoethanol; Morphine; Morphine Derivatives | 1987 |
Effect of morphinone on opiate receptor binding and morphine-elicited analgesia.
Specific binding of 3H-naloxone to opiate receptors was found to be irreversibly inactivated by morphine. This inactivation exhibited pseudo-first-order kinetics. The presence of sulfhydryl compounds or morphine during incubation with morphinone proved good protection. Morphinone-pretreated mice blocked the analgesic effect of morphine. The possible mechanism for these observations is proposed as follows: morphinone binds covalently to sulfhydryl group of opiate receptors, and inactivates irreversibly opiate binding sites, thus blocking the analgesic effect of morphine. Topics: Analgesia; Animals; Cysteine; Dihydromorphine; Glutathione; Hydromorphone; Kinetics; Mice; Morphine; Naloxone; Receptors, Opioid | 1982 |