dihydrolipoic acid has been researched along with thioctic acid in 237 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (6.33) | 18.7374 |
| 1990's | 75 (31.65) | 18.2507 |
| 2000's | 70 (29.54) | 29.6817 |
| 2010's | 66 (27.85) | 24.3611 |
| 2020's | 11 (4.64) | 2.80 |
| Authors | Studies |
|---|---|
| Brownlee, JM; Carlson, E; Harrison, DH; Milne, AC; Pape, E | 1 |
| Killen, E; Richardson, SG | 1 |
| Burns, HD; Marzilli, LG; Worley, P | 1 |
| Forte, T; Kagan, VE; Packer, L; Scita, G; Serbinova, EA | 1 |
| Goldman, R; Kagan, V; Packer, L; Scita, G; Witt, E | 1 |
| Cross, CE; Packer, L; Suzuki, YJ; Thompson, DF; Tsuchiya, M | 1 |
| Karkoutly, C; Krieglstein, J; Nuglisch, J; Peruche, B; Prehn, JH | 1 |
| Burkart, V; Kallmann, B; Kolb, H; Kolb-Bachofen, V; Kröncke, KD | 1 |
| Kagan, VE; Khan, S; Packer, L; Powell, R; Serbinova, E; Shvedova, A; Swanson, C | 1 |
| Murphy, ME; Scholich, H; Sies, H | 2 |
| Preiss, R; Teichert, J | 2 |
| Packer, L; Suzuki, YJ; Tsuchiya, M | 3 |
| Forte, T; Freisleben, HJ; Kagan, VE; Packer, L; Tsuchiya, M | 1 |
| Krüger, E; Mainka, L; Zimmer, G | 1 |
| Buneeva, OA; Bunik, VI; Gomazkova, VS | 2 |
| Bast, A; De Rooij, BM; Haenen, GR; Vermeulen, NP | 1 |
| Menzel, H; Müller, L | 1 |
| Bonomi, F; Cerioli, A; Pagani, S | 1 |
| Frey, PA; Yang, YS | 1 |
| Basu, A; Das Gupta, SC; Gomes, A; Lahiri, SC | 1 |
| Bonomi, F; Pagani, S | 1 |
| Heine, HG; Richarme, G | 1 |
| Bourguignon, J; Douce, R; Neuburger, M | 1 |
| Bonomi, F; Cerletti, P; Pagani, S | 1 |
| Futaki, S | 1 |
| Chen, C; Loo, G | 1 |
| Mizuno, M; Packer, L | 2 |
| Aruoma, OI; Cross, CE; Evans, PJ; Halliwell, B; O'Neill, C; Scott, BC; Tritschler, H; Van der Vliet, A | 1 |
| Bustamante, J; Orrenius, S; Slater, AF | 1 |
| Gille, L; Nohl, H; Schönheit, K | 1 |
| Constantinescu, A; Han, D; Handelman, GJ; Haramaki, N; Packer, L; Pick, U; Podda, M; Tritschler, HJ | 1 |
| Cadenas, E | 1 |
| Bast, A; Biewenga, GP | 1 |
| Kawabata, T; Packer, L; Tritschler, HJ | 1 |
| Cross, CE; Halliwell, B; O'Neill, CA; van der Vliet, A | 1 |
| Mizuno, M; Packer, L; Suzuki, YJ; Tritschler, HJ | 1 |
| Bisswanger, H; Borbe, HO; Bunik, V; Follmann, H; Loeffelhardt, S; Shoubnikova, A | 1 |
| Jouenne, T; Junter, GA; Tresse, O | 1 |
| Darrow, RM; Goldman, R; Kagan, VE; Organisciak, DT; Stoyanovsky, DA | 1 |
| Han, D; Packer, L; Tritschler, HJ | 1 |
| Claycamp, HG; Goldman, R; Kagan, VE; Stoyanovsky, DA | 1 |
| Packer, L; Podda, M; Tritschler, HJ; Ulrich, H | 1 |
| Constantinescu, A; Packer, L; Tritschler, H | 1 |
| Freisleben, HJ; Fuchs, J; Groth, N; Herrling, T; Rudolph, P; Zimmer, G | 1 |
| Kawabata, T; Packer, L; Schepkin, V | 1 |
| Fuchs, J; Milbradt, R | 1 |
| Day, BW; Gantchev, TG; Goldman, R; Kagan, VE; Stoyanovsky, DA; Yalowich, JC | 1 |
| Cross, CE; Davis, PA; Halliwell, B; O'Neill, CA; Packer, L; Reznick, AZ; Rieland, T; Strohman, WJ; Tritschler, H; van der Vliet, A | 1 |
| Garcia-Osuna, M; Greenamyre, JT; Greene, JG | 1 |
| Kawabata, T; Packer, L; Yap, SC | 1 |
| Gantchev, T; Kagan, V; Stoyanovsky, D; Yalowich, J | 1 |
| Legastelois, S; Métais, MP; Monier, JC; Moreira, A; Quash, G; Tebib, J; Thomas, V | 1 |
| Han, D; Handelman, GJ; Packer, L; Tritschler, H | 1 |
| Aizenman, E; Tang, LH | 1 |
| Assadnazari, H; Haramaki, N; Packer, L; Zimmer, G | 1 |
| Scheer, B; Zimmer, G | 1 |
| Brenner, HH; Burkart, V; Imai, Y; Koike, T; Kolb, H | 1 |
| Colnaghi, R; Pagani, S; Sessa, F; Sessa, G | 1 |
| Assadnazari, H; Freisleben, HJ; Leibfritz, D; Werk, W; Zimmer, G | 1 |
| Halliwell, B; Tritschler, H; Whiteman, M | 1 |
| Assadnazari, H; Haramaki, N; Packer, L; Schepkin, V; Zimmer, G | 1 |
| Han, D; Matsugo, S; Packer, L; Tritschler, HJ; Yan, LJ | 1 |
| Bisby, RH; Johnson, SA; Parker, AW | 1 |
| Konishi, T; Matsugo, S; Matsuo, D; Packer, L; Tritschler, HJ | 1 |
| Kawabata, T; Packer, L; Schepkin, V; Tritschler, HJ | 1 |
| Han, D; Matsugo, S; Packer, L; Tritschler, HJ | 1 |
| Hoffmann, P; Labidalle, S; Nepveu, F; Petit, C; Souchard, JP | 1 |
| Gille, L; Nohl, H; Staniek, K | 1 |
| Flohé, L; Han, D; Handelman, G; Kobuchi, H; Marcocci, L; Packer, L; Roy, S; Sen, CK; Tritschler, HJ | 1 |
| Rüstow, B; Witt, W | 1 |
| Karjalainen, A; Lindros, KO; Saris, NE; Teplova, VV | 1 |
| Bisby, RH; Parker, AW | 1 |
| Bereiter-Hahn, J; Schneider, M; Thürich, T; Zimmer, G | 1 |
| Bast, A; Biewenga, GP; Haenen, GR; Nicastia, AJ; Veening-Griffioen, DH | 1 |
| Packer, L; Roy, S | 1 |
| Lodge, JK; Packer, L; Traber, MG | 1 |
| Khanna, S; Packer, L; Roy, S; Sen, CK | 1 |
| Gille, L; Kozlov, AV; Nohl, H; Staniek, K | 1 |
| Hong, YS; Jacobia, SJ; Packer, L; Patel, MS | 1 |
| Fischer, GM; Gallyas, F; Kispal, G; Sumegi, B; Szabados, E | 1 |
| Assaf, P; Haj-Yehia, AI; Katzhendler, J; Nassar, T | 1 |
| Biaglow, JE; Chrestensen, C; Donahue, J; Held, K; Mieyal, J; Tuttle, S | 1 |
| Morkunaite, S; Saris, NE; Teplova, VV | 1 |
| Freisleben, HJ | 2 |
| Berni, R; Cianci, M; Gliubich, F; Zanotti, G | 1 |
| Guo, Q; Packer, L | 1 |
| Self, WT; Stadtman, TC; Tsai, L | 1 |
| Haugaard, N; Levin, RM | 2 |
| Courteau, J; Kocsis-Bédard, S; Niyonsenga, T; Paquette, B; Thibodeau, PA | 1 |
| Grundmann-Kollmann, M; Kaufmann, R; Packer, L; Podda, M; Thiele, JJ; Zollner, TM | 1 |
| Borisenko, GG; Fabisiak, JP; Kagan, VE; Lazo, JS; Pearce, LL; Pitt, BR; Razzack, J; Tyhurina, YY; Tyurin, VA | 1 |
| Elstner, EF; Schneider, D | 1 |
| Mason, RP; Mottley, C | 1 |
| Buse, MG; Greene, EL; Nelson, BA; Robinson, KA | 1 |
| Carr, AC; Myzak, MC | 1 |
| Aposhian, HV; Radabaugh, TR; Sampayo-Reyes, A; Zakharyan, RA | 1 |
| Moini, H; Packer, L; Saris, NE | 1 |
| Chang, CM; Chen, HJ; Chen, YM | 2 |
| Choi, DW; Choi, EH; Dugan, LL; Kim-Han, JS; Sheline, CT | 1 |
| Sigalov, AB; Stern, LJ | 1 |
| Lockwood, TD | 2 |
| Bunik, VI; Sievers, C | 1 |
| Gille, L; Kruglov, AG; Morkunaite-Haimi, S; Nohl, H; Saris, NE; Stolze, K; Teplova, VV | 1 |
| Kagan, VE; Kisin, ER; Kuzmenko, AI; Li, R; Martin, I; Quinn, PJ; Shvedova, AA; Tyurin, VA; Tyurina, YY; Yalowich, JC | 1 |
| Coppey, LJ; Davidson, EP; Gellett, JS; Yorek, MA | 1 |
| Ito, S; Koda, N; Niwa, H; Ohkubo, H; Ohmiya, Y; Tanikawa, N; Watanabe, K | 1 |
| Koenig, ML; Meyerhoff, JL | 1 |
| Lang, U; Oetjen, U; Riedel, W; Schlapp, U; Shibata, M | 1 |
| WEBB, M | 1 |
| FUKUYAMA, T; HOKAMA, Z; KAWAMURA, Y; LIN, YH; MAKINO, M; MIYAZAKI, S; MUTO, S; SAWAI, Y; SHIMIZU, T | 1 |
| HILZ, H; KITTLER, M | 1 |
| ATHERTON, NM; MASSEY, V | 1 |
| Ciofani, G; Cuccurullo, F; Giamberardino, MA; Lapenna, D; Pierdomenico, SD | 1 |
| Bast, A; Haenen, GR; Rezk, BM; van der Vijgh, WJ | 1 |
| Bucher, G; Lu, C; Sander, W | 2 |
| deSzoeke, E; Frei, B; Hagen, TM; Suh, JH; Zhu, BZ | 1 |
| Christopher, MM; Hill, AS; O'Neill, SL; Rogers, QR; Werner, JA | 1 |
| Hagen, TM; Shenvi, SV; Smith, AR; Suh, JH; Widlansky, M | 1 |
| Lee, JK; Meyerhoff, JL; Rittase, BW; Tsang, AY; Yourick, DL | 1 |
| Bourdette, DN; Marquardt, WE; Marracci, GH; McKeon, GP; Riscoe, MK; Winter, RW | 1 |
| Christopher, MM; Hill, AS; O'Neill, SL; Rogers, QR | 1 |
| Jaiswal, JK; Mattoussi, H; Medintz, IL; Simon, SM; Uyeda, HT | 1 |
| Kruszyna, HG; Rich, AM; Spuches, AM; Wilcox, DE | 1 |
| Daniel, H; Nickel, A; Wenzel, U | 1 |
| Cantin, AM; Drouin, G; Martel, M; Paquette, B | 1 |
| Beck, CN; Fitzgibbon, WR; Gelasco, AK; Morinelli, TA; Ullian, ME | 1 |
| Bartesaghi, S; Folkes, L; Kalyanaraman, B; Radi, R; Trujillo, M; Wardman, P | 1 |
| Cakatay, U | 1 |
| Accurso, FJ; del Val, G; Lee, RL; Pack, K; Pardee, C; Rancourt, RC; White, CW | 1 |
| Anand, D; Billiar, TR; Gius, D; Ivanova, J; Kagan, VE; Mandavia, DN; Pitt, B; Stoyanovsky, DA; Tyurin, VA; Tyurina, YY | 1 |
| Hirohata, M; Ono, K; Yamada, M | 1 |
| Bawendi, MG; Frangioni, JV; Kim, SW; Ohnishi, S; Tanaka, E; Zimmer, JP | 1 |
| Hatani, T; Okada, T; Tehara, T; Tsuji-Naito, K | 1 |
| Coleman, MD; Haenen, GR; Williams, C | 1 |
| Jameel, NM; Shekhar, MA; Vishwanath, BS | 1 |
| Coleman, MD; Haenen, GR; Rimmer, GS | 1 |
| Aerry, R; Coleman, MD; Khan, NB; Lambert, PA; Rathbone, DL; Wanogho, E | 1 |
| Ho, SY; Ho, YS; Lai, CS; Liu, HI; Pan, MH; Tai, C; Wang, YJ | 1 |
| Delehanty, JB; Mattoussi, H; Medintz, IL; Pons, T; Susumu, K; Uyeda, HT | 1 |
| Chompoosor, A; Han, G; Rotello, VM | 1 |
| Csokai, V; Dranchak, PK; Hacia, JG; Hu, W; Lecane, P; Lynch, V; Ma, X; Magda, D; Sessler, JL; Thiemann, P; Wang, X; Wang, Z; Wei, W | 1 |
| Clayton, AH; Gunzburg, MJ; Howlett, GJ; Lees, EE; Mulvaney, P; Nguyen, TL; Nice, EC; Rothacker, J | 1 |
| Amoureux, S; Delemasure, S; Ghibu, S; Lauzier, B; Mogosan, C; Muresan, A; Rochette, L; Sicard, P; Vergely, C | 1 |
| Pan, MH; Wang, YJ; Yang, MC | 1 |
| Mattoussi, H; Medintz, IL; Mei, BC; Susumu, K | 1 |
| Mattoussi, H; Mei, BC; Susumu, K | 1 |
| Himabindhu, G; Thaakur, S | 1 |
| Atkins, JL; Billiar, TR; Kagan, VE; Sengupta, R; Stoyanovsky, DA | 1 |
| Konishi, T; Matsugo, S; Wada, N; Wakami, H | 1 |
| Blanco-Canosa, JB; Boeneman, K; Dawson, PE; Deschamps, JR; Medintz, IL; Prasuhn, DE; Stewart, MH; Susumu, K | 1 |
| Dubertret, B; Fragola, A; Lenkei, Z; Lequeux, N; Muro, E; Pons, T; Sanson, N | 1 |
| Bigioni, M; Carbonelli, MG; De Lorenzo, A; Di Daniele, N; Di Renzo, L; Fusco, MA | 1 |
| Chung, FL; Emami, A; Nath, RG; Wu, MY | 1 |
| Leblanc, RM; Vannoy, CH | 1 |
| Seybolt, SE | 1 |
| Bourdette, DN; Carr, DW; Regan, JW; Salinthone, S; Schillace, RV; Tsang, C | 1 |
| Liu, D; Snee, PT | 1 |
| Foo, NP; Lee, YH; Lin, SH; Wang, YJ; Wu, MJ | 1 |
| Chan, WH; Chang, WH; Houng, WL; Hsieh, JT; Lee, CH; Li, PW; Lin, CA; Shen, JL; Yeh, HI | 1 |
| Aldeek, F; Balan, L; Fontaine-Aupart, MP; Mustin, C; Roques-Carmes, T; Schneider, R | 1 |
| Iqbal, N; Iqbal, Z; Kashif, M; Khan, A; Khan, I; Muhammad, N; Muhammad, S; Nasib, HA; Watson, DG | 1 |
| Algar, WR; Blanco-Canosa, JB; Boeneman, K; Dawson, PE; Delehanty, JB; Hervey, WJ; Jain, V; Johnson, BJ; Medintz, IL; Oh, E; Susumu, K | 1 |
| Berti, L; English, DS; Farrell, D; Grimes, AF; Mattoussi, H; Medintz, IL; Pons, T; Wang, X | 1 |
| Kimura, H; Kimura, Y; Mikami, Y; Nagahara, N; Ogasawara, Y; Shibuya, N | 1 |
| Kikkeri, R; Laurino, P; Seeberger, PH | 1 |
| Ciejka, E; Gorąca, A; Huk-Kolega, H; Kleniewska, P; Piechota, A; Skibska, B | 1 |
| Mikulski, D; Molski, M; Szeląg, M | 1 |
| Mattoussi, H; Na, HB; Palui, G | 1 |
| Gao, J; Huang, X; Liu, H; Ren, J; Zan, F | 1 |
| Bai, WJ; Gao, M; Long, YJ; Wang, QL; Xiao, GF; Zhang, HJ; Zhang, LY; Zheng, HZ | 1 |
| Dubertret, B; Fragola, A; Ioannou, A; Lequeux, N; Muro, E; Pons, T; Skourides, P | 1 |
| Avellini, T; Ji, X; Knappenberger, KL; Mattoussi, H; Na, HB; Palui, G; Yi, C | 1 |
| Bruns, M; Gerthsen, D; Nienhaus, GU; Popescu, R; Shang, L; Stockmar, F; Trouillet, V; Yang, L | 1 |
| Chan, WH; Chang, WH; Houng, WL; Lin, CJ; Shen, JL; Wang, HH; Yeh, HI | 1 |
| Asard, H; Bérczi, A; Zimányi, L | 1 |
| Dong, H; Liu, J; Liu, L; Ma, X; Song, E; Song, Y; Tian, X | 1 |
| Huang, X; Long, Y; Wang, Q; Zhang, H; Zheng, H; Zhu, R | 1 |
| Bartosz, G; Boudier, A; Eidi, H; Joubert, O; Leroy, P; Maincent, P; Sapin-Minet, A; Tournebize, J | 1 |
| Boudier, A; Leroy, P; Maincent, P; Sapin-Minet, A; Schneider, R; Tournebize, J | 1 |
| Eisenberg, R; Han, Z; Holland, PL; Krauss, TD; Qiu, F | 1 |
| Bravo, L; d'Ischia, M; Goya, L; Martín, MA; Napolitano, A; Panzella, L; Ramos, S; Verotta, L | 1 |
| Cottin, Y; Ghibu, S; Richard, C; Rochette, L; Vergely, C; Zeller, M | 1 |
| Aradhyam, GK; Nair, SP; Singh, V | 1 |
| Hisamori, M; Koizumi, R; Kumagai, Y; Taguchi, K | 1 |
| Deeth, HC; Oh, HE; Sharma, R; Wijayanti, HB | 1 |
| Bergamini, C; Bolognesi, ML; Fato, R; Oiry, J; Smietana, M; Vasseur, JJ | 1 |
| Compton, DL; Evans, KO; Laszlo, JA | 1 |
| Alvarez-Idaboy, JR; Castañeda-Arriaga, R | 1 |
| Algar, WR; Medintz, IL; Petryayeva, E; Wu, M | 1 |
| Amin, MA; Balogh, B; Fox, DA; Khanna, D; Koch, AE; Lozier, A; Pinney, AJ; Schiopu, E; Stinson, WA; Tsou, PS; Zakhem, G | 1 |
| Iqbal, Z; Khan, A; Khan, MI | 1 |
| Gamaleĭ, IA; Kirpichnikova, KM; Liublinskaia, OG | 1 |
| Bayer, SB; Hampton, MB; Winterbourn, CC | 1 |
| Bozhokina, E; Gamaley, I; Khaitlina, S | 1 |
| Brandt, YI; Hartley, RS; Mitchell, T; Osiński, M; Smolyakov, GA | 1 |
| Dörsam, B; Fahrer, J; Göder, A; Kaina, B; Kraus, A; Nagel, G; Seiwert, N | 1 |
| Ghibu, S; Muresan, A; Rochette, L; Vergely, C | 1 |
| Guo, B; Hou, Y; Ke, C; Li, H; Li, K; Li, Y; Wang, J; Yang, K; Zhang, F; Zhang, H; Zhou, X | 1 |
| Erickson, A; Moreau, R; Xia, M; Yi, X | 1 |
| Das, T; Poria, DK; Purkayastha, P | 1 |
| Cilaker Micili, S; De Grazia, S; Goker, A; Monastra, G; Unfer, V | 1 |
| Liang, J; Wang, S; Wang, W; Wen, W; Xiong, H; Zhang, X; Zheng, H | 1 |
| Bilska-Wilkosz, A; Górny, M; Iciek, M; Kowalczyk-Pachel, D; Sokołowska-Jeżewicz, M; Włodek, L | 1 |
| Bai, SL; Chen, YE; Du, JB; Feng, LY; He, YK; Hu, Y; Kong, DD; Liu, WJ; Luo, S; Wang, CQ; Xu, XC; Yuan, M; Yuan, S; Zhang, GC; Zhang, ZW; Zheng, C; Zhou, YH | 1 |
| Bouzas-Ramos, D; Costa-Fernández, JM; Encinar, JR; García-Cortes, M; Sanz-Medel, A | 1 |
| Costa-Fernández, JM; Fernández-Argüelles, MT; García-Cortés, M; Sanz-Medel, A | 1 |
| Colannino, G; Monastra, G; Parente, E; Picconi, O | 1 |
| Chen, S; Enkhjargal, B; Malaguit, J; Sun, C; Tang, J; Wu, L; Xie, Z; Zhang, J; Zhang, JH; Zhou, K | 1 |
| Bednarski, M; Bilska-Wilkosz, A; Dudek, M; Filipek, B; Gorny, M; Iciek, M; Kowalczyk-Pachel, D; Nowinski, L; Sokolowska-Jezewicz, M; Wlodek, L | 1 |
| García-Borrón, JC; Micillo, R; Napolitano, A; Olivares, C; Panzella, L; Sirés-Campos, J | 1 |
| Bashllari, R; Cimino, F; Fratantonio, D; Molonia, MS; Monastra, G; Palumbo, M; Saija, A; Speciale, A; Virgili, F | 1 |
| Du, Y; He, W; Ismail, M; Li, X; Ling, L; Xia, Q; Yao, C | 1 |
| Aaseth, J; Bjørklund, G; Chirumbolo, S; Crisponi, G; Rahman, MM | 1 |
| Bilska-Wilkosz, A; Górny, M; Iciek, M | 1 |
| Mattoussi, H; Palui, G; Perng, W; Wang, W | 1 |
| Anderson, GJ; Frazer, DM; Lim, YC; Liu, T; Wei, F; Xiao, L; Xiao, Y; Zhou, Y | 1 |
| Binte Hossain, KF; Hosokawa, T; Kurasaki, M; Rahman, MM; Saito, T; Sikder, MT | 1 |
| Akshath, US; Guo, Y; Hondow, N; Jiang, J; Kong, Y; Li, S; Tian, X; Tiede, C; Wang, W; Yu, A; Zhou, D | 1 |
| Bian, H; Huang, J; Liang, L; Wang, G; Wang, H; Wei, Y; Xiao, L; Zheng, Y | 1 |
| Chen, WQ; He, XH; Jiang, FL; Liu, Y; Song, PJ; Yin, MM | 1 |
| Chang, WH; Hou, TY; Lin, CJ; Shao, FY; Sun, YT; Yang, KS | 1 |
| Biernat-Sudolska, M; Bilska-Wilkosz, A; Rojek-Zakrzewska, D | 1 |
| Akter, M; Hossain, KFB; Kimura, G; Kurasaki, M; Rahaman, MS; Rahman, MM; Saito, T; Sikder, MT; Tomihara, T; Yamasaki, S | 1 |
| Enkhjargal, B; Mo, J; Reis, C; Tang, J; Wu, P; Zhang, J; Zhang, JH; Zhang, T; Zhou, K; Zhu, Q | 1 |
| Lee, HI; Lee, YN; Lin, CJ; Peng, HY; Tseng, YM; Wang, HH; Wu, YJ; Yang, PS; Yeh, HI | 1 |
| Li, D; Lin, S; Mei, X; Tian, H; Xu, C; Zhou, Z | 1 |
10 review(s) available for dihydrolipoic acid and thioctic acid
| Article | Year |
|---|---|
[Effects of some antidotes on injuries induced by arsenic in rat mucous membrane (author's transl)].
Topics: Animals; Antidotes; Arsenic; Arsenic Trioxide; Arsenicals; Glutathione; Mouth Mucosa; Oxides; Rats; Thioctic Acid | 1982 |
High-performance liquid chromatography methods for determination of lipoic and dihydrolipoic acid in human plasma.
Topics: Biological Assay; Chromatography, High Pressure Liquid; Humans; Thioctic Acid | 1997 |
Redox regulation of cell functions by alpha-lipoate: biochemical and molecular aspects.
Topics: Animals; Antioxidants; Apoptosis; Cell Physiological Phenomena; Gene Expression; Glutamic Acid; Glutathione; Humans; Oxidation-Reduction; Thioctic Acid | 1998 |
Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid.
Topics: Animals; Antioxidants; Free Radical Scavengers; Humans; Mice; Nitric Oxide; Oxidation-Reduction; Rats; Reactive Oxygen Species; Thioctic Acid | 2002 |
Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.
Topics: Animals; Antioxidants; Chelation Therapy; Chronic Disease; Coenzymes; Diabetic Neuropathies; Free Radical Scavengers; Heavy Metal Poisoning, Nervous System; Humans; Metals, Heavy; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Signal Transduction; Thioctic Acid | 2004 |
Lipoic acid - biological activity and therapeutic potential.
Topics: Animals; Antioxidants; Cattle; Cytokines; Dietary Supplements; Free Radicals; Humans; Thioctic Acid | 2011 |
Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential.
Topics: Animals; Antioxidants; Cardiovascular Diseases; Chelating Agents; Diabetes Mellitus; Dietary Supplements; Endothelial Cells; Humans; Hyperglycemia; Inflammation; Mitochondria; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Thioctic Acid | 2013 |
Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus; Humans; Mitochondria; Oxidative Stress; Reactive Nitrogen Species; Reactive Oxygen Species; Thioctic Acid | 2015 |
Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriage.
Topics: Abortion, Spontaneous; Anti-Inflammatory Agents; Antioxidants; Female; Humans; Mitochondria; Oxidation-Reduction; Pregnancy; Thioctic Acid | 2016 |
Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology.
Topics: Animals; Chelating Agents; Free Radical Scavengers; Humans; Methylmercury Compounds; Oxidative Stress; Thioctic Acid | 2019 |
227 other study(ies) available for dihydrolipoic acid and thioctic acid
| Article | Year |
|---|---|
Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Topics: Aldehyde Reductase; Carboxylic Acids; Enzyme Inhibitors; Humans; Mutation, Missense; Protein Conformation; Substrate Specificity; Thermodynamics | 2006 |
Metabolism of oestradiol by human mammary tumour 800 x g supernatants pretreated with dihydrolipoic acid.
Topics: Breast Neoplasms; Estradiol; Humans; Thioctic Acid; Tritium | 1977 |
A new electrophoretic method for determining ligand: technetium stoichiometry in carrier free 99mTc-radiopharmaceuticals.
Topics: Chemical Phenomena; Chemistry; Dimercaprol; Electrophoresis; Ligands; Technetium; Thioctic Acid | 1979 |
Recycling of vitamin E in human low density lipoproteins.
Topics: Ascorbic Acid; beta Carotene; Carotenoids; Chromans; Drug Synergism; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Humans; Linolenic Acids; Lipid Peroxidation; Lipoproteins, LDL; Lipoxygenase; Thioctic Acid; Ultraviolet Rays; Vitamin E | 1992 |
Ultraviolet light-induced generation of vitamin E radicals and their recycling. A possible photosensitizing effect of vitamin E in skin.
Topics: Animals; Antioxidants; Ascorbic Acid; beta Carotene; Carotenoids; Electron Spin Resonance Spectroscopy; Free Radicals; Liposomes; Methanol; Mice; Mice, Hairless; Models, Biological; Neoplasms, Radiation-Induced; Oxygen; Phosphatidylcholines; Radiation Tolerance; Skin; Skin Neoplasms; Suspensions; Thioctic Acid; Ultraviolet Rays; Vitamin E; Water | 1992 |
Superoxide formed from cigarette smoke impairs polymorphonuclear leukocyte active oxygen generation activity.
Topics: Animals; Antioxidants; beta Carotene; Carotenoids; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Kinetics; Luminescent Measurements; Male; Neutrophils; Nicotiana; Plants, Toxic; Rats; Rats, Wistar; Smoke; Spin Labels; Superoxides; Tetradecanoylphorbol Acetate; Thioctic Acid; Vitamin E | 1992 |
Dihydrolipoate reduces neuronal injury after cerebral ischemia.
Topics: Animals; Blood Glucose; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Glutamates; Glutamic Acid; Mice; Nervous System; Neurons; Rats; Rats, Inbred F344; Rectum; Thioctic Acid; Thiourea | 1992 |
Toxicity of chemically generated nitric oxide towards pancreatic islet cells can be prevented by nicotinamide.
Topics: Acetylcysteine; Animals; Benzamides; Cell Survival; Cells, Cultured; Free Radical Scavengers; In Vitro Techniques; Islets of Langerhans; Kinetics; Niacinamide; Nitric Oxide; Nitroprusside; Penicillamine; Poly(ADP-ribose) Polymerase Inhibitors; Rats; Rats, Inbred Strains; S-Nitroso-N-Acetylpenicillamine; Sodium Cyanide; Thioctic Acid; Thiosulfate Sulfurtransferase; Vasodilator Agents | 1992 |
Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals.
Topics: Animals; Antioxidants; Ascorbic Acid; Azo Compounds; Chromans; Female; Free Radicals; Intracellular Membranes; Lipid Peroxidation; Liposomes; Microsomes, Liver; NAD; NADP; Nitriles; Oxidation-Reduction; Peroxides; Rats; Rats, Sprague-Dawley; Thioctic Acid | 1992 |
Protection by glutathione and other thiol compounds against the loss of protein thiols and tocopherol homologs during microsomal lipid peroxidation.
Topics: Adenosine Diphosphate; Animals; Ascorbic Acid; Cysteine; Dithioerythritol; Glutathione; Iron; Lipid Peroxidation; Luminescent Measurements; Microsomes, Liver; NADP; Rats; Sulfhydryl Compounds; Thioctic Acid; Vitamin E | 1992 |
HPLC-methods for determination of lipoic acid and its reduced form in human plasma.
Topics: Chromatography, High Pressure Liquid; Electrochemistry; Humans; Hydrolysis; Male; Oxidation-Reduction; Thioctic Acid | 1992 |
Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species.
Topics: Antioxidants; Binding, Competitive; Electron Spin Resonance Spectroscopy; Epinephrine; Free Radicals; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Kinetics; Oxygen; Superoxides; Thioctic Acid | 1991 |
Generation of probucol radicals and their reduction by ascorbate and dihydrolipoic acid in human low density lipoproteins.
Topics: Antioxidants; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen Peroxide; Lipoproteins, LDL; Luminescent Measurements; Oxidation-Reduction; Phenols; Spectrometry, Fluorescence; Thioctic Acid; Vitamin E | 1991 |
Dihydrolipoic acid activates oligomycin-sensitive thiol groups and increases ATP synthesis in mitochondria.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Atractyloside; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Female; Kinetics; Mitochondria, Heart; Oleic Acid; Oleic Acids; Oligomycins; Oxidative Phosphorylation; Palmitic Acid; Palmitic Acids; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Thioctic Acid | 1991 |
[Regulation of cooperative properties of alpha-ketoglutarate dehydrogenase by means of thiol-disulfide metabolism].
Topics: Animals; Columbidae; Disulfides; Ketoglutarate Dehydrogenase Complex; Muscles; Oxidation-Reduction; Substrate Specificity; Sulfhydryl Compounds; Thioctic Acid | 1991 |
Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen.
Topics: Azoles; Chemical Phenomena; Chemistry; Glutathione; Hydrogen Peroxide; In Vitro Techniques; Isoindoles; Kinetics; Mass Spectrometry; Organoselenium Compounds; Peroxidases; Selenium; Spectrum Analysis; Sulfhydryl Compounds; Thioctic Acid | 1990 |
Studies on the efficacy of lipoate and dihydrolipoate in the alteration of cadmium2+ toxicity in isolated hepatocytes.
Topics: Animals; Cadmium; Cadmium Poisoning; In Vitro Techniques; Kinetics; Lipid Peroxidation; Liver; Oxidation-Reduction; Rats; Thioctic Acid | 1990 |
Change in alpha-ketoglutarate dehydrogenase cooperative properties due to dihydrolipoate and NADH.
Topics: Allosteric Regulation; Animals; Columbidae; Diethyl Pyrocarbonate; Ketoglutarate Dehydrogenase Complex; Ketone Oxidoreductases; Macromolecular Substances; Muscles; NAD; Oxidation-Reduction; Protein Conformation; Sulfhydryl Compounds; Thioctic Acid | 1990 |
Molecular aspects of the removal of ferritin-bound iron by DL-dihydrolipoate.
Topics: Chemical Phenomena; Chemistry, Physical; Chlorides; Ferric Compounds; Ferritins; Hydrogen-Ion Concentration; In Vitro Techniques; Iron; Kinetics; Oxidation-Reduction; Phenanthrolines; Spectrum Analysis; Sulfhydryl Compounds; Thioctic Acid; Time Factors | 1989 |
2-ketoacid dehydrogenase complexes of Escherichia coli: stereospecificities of the three components for (R)-lipoate.
Topics: Acetylation; Escherichia coli; Ketoglutarate Dehydrogenase Complex; Ketone Oxidoreductases; Oxidation-Reduction; Pyruvate Dehydrogenase Complex; Stereoisomerism; Substrate Specificity; Thioctic Acid | 1989 |
Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol.
Topics: Animals; Lipid Peroxides; Luminescent Measurements; Microsomes; Rats; Thiobarbiturates; Thioctic Acid; Time Factors; Vitamin E | 1989 |
Comparative detoxification and protection of scorpion (Heterometrus bengalensis) venom by toxoid antiserum.
Topics: Animals; Antivenins; Formaldehyde; Guinea Pigs; Mice; Muscle Contraction; Myocardial Contraction; Rats; Scorpion Venoms; Scorpions; Swine; Thioctic Acid; Toxoids | 1989 |
Removal of ferritin-bound iron by DL-dihydrolipoate and DL-dihydrolipoamide.
Topics: Chromatography, Gel; Dithionite; Ferritins; Hydrogen-Ion Concentration; Iron; Thioctic Acid | 1986 |
Galactose- and maltose-stimulated lipoamide dehydrogenase activities related to the binding-protein-dependent transport of galactose and maltose in toluenized cells of Escherichia coli.
Topics: ATP-Binding Cassette Transporters; Biological Transport; Calcium-Binding Proteins; Carrier Proteins; Dihydrolipoamide Dehydrogenase; Edetic Acid; Enzyme Activation; Escherichia coli; Escherichia coli Proteins; Galactose; Genes, Bacterial; Maltose; Maltose-Binding Proteins; Monosaccharide Transport Proteins; Mutation; NAD; Operon; Periplasmic Binding Proteins; Thioctic Acid; Toluene | 1986 |
Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase.
Topics: Amino Acid Oxidoreductases; Aminomethyltransferase; Carrier Proteins; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Glycine; Glycine Decarboxylase Complex H-Protein; Glycine Dehydrogenase (Decarboxylating); Glycine Hydroxymethyltransferase; Hydroxymethyl and Formyl Transferases; Mitochondria; Multienzyme Complexes; NAD; Oxidation-Reduction; Plant Proteins; Plants; Pyruvate Dehydrogenase Complex; Tetrahydrofolates; Thioctic Acid; Transferases | 1988 |
The inhibition of rhodanese by lipoate and iron-sulfur proteins.
Topics: Animals; Cattle; Iron-Sulfur Proteins; Kinetics; Liver; Metalloproteins; Sulfurtransferases; Thioctic Acid; Thiosulfate Sulfurtransferase | 1983 |
Inhibition of lecithin: cholesterol acyltransferase activity in human blood plasma by cigarette smoke extract and reactive aldehydes.
Topics: Adult; Aldehydes; Arteriosclerosis; Glutathione; Humans; Male; Nicotiana; Phosphatidylcholine-Sterol O-Acyltransferase; Plants, Toxic; Smoke; Thioctic Acid; Time Factors | 1995 |
Suppression of protooncogene c-fos expression by antioxidant dihydrolipoic acid.
Topics: Antioxidants; Gene Expression Regulation, Leukemic; Humans; Leukemia, T-Cell; Proto-Oncogene Proteins c-fos; Thioctic Acid; Tumor Cells, Cultured | 1995 |
Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation.
Topics: alpha 1-Antitrypsin; Animals; Antioxidants; Arachidonic Acid; Ascorbic Acid; Bleomycin; Brain; Cattle; Deoxyribose; DNA Damage; Free Radical Scavengers; Hydrogen Peroxide; Hypochlorous Acid; Lipid Peroxidation; Liposomes; Myoglobin; Superoxides; Thioctic Acid | 1994 |
Antioxidant inhibition of thymocyte apoptosis by dihydrolipoic acid.
Topics: Animals; Antioxidants; Apoptosis; Cell Survival; Cells, Cultured; Chromatin; Etoposide; Glutathione; Glutathione Disulfide; Male; Methylprednisolone; Microscopy, Confocal; Rats; Rats, Sprague-Dawley; Thioctic Acid; Thymus Gland | 1995 |
Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria.
Topics: Animals; Hemodynamics; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidative Stress; Perfusion; Rats; Rats, Sprague-Dawley; Thioctic Acid | 1995 |
Reduction and transport of lipoic acid by human erythrocytes.
Topics: Biological Transport; Chromatography, High Pressure Liquid; Dihydrolipoamide Dehydrogenase; Erythrocyte Membrane; Erythrocytes; Glutathione Reductase; Humans; In Vitro Techniques; Liposomes; NADP; Oxidation-Reduction; Thioctic Acid | 1995 |
Thiyl radical formation during thiol oxidation by ferrylmyoglobin.
Topics: Animals; Electron Spin Resonance Spectroscopy; Free Radicals; Metmyoglobin; Oxidation-Reduction; Recombinant Proteins; Spin Labels; Structure-Activity Relationship; Sulfhydryl Compounds; Thioctic Acid; Whales | 1995 |
Reaction of lipoic acid with ebselen and hypochlorous acid.
Topics: Antioxidants; Azoles; Catalysis; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Hypochlorous Acid; Isoindoles; Kinetics; Molecular Structure; Organoselenium Compounds; Spectrophotometry; Thioctic Acid | 1995 |
Reaction of (R,S)-dihydrolipoic acid and homologs with iron.
Topics: Disulfides; Indicators and Reagents; Iron; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Spectrophotometry; Structure-Activity Relationship; Sulfhydryl Compounds; Thioctic Acid | 1995 |
Plasma protein sulfhydryl oxidation: effect of low molecular weight thiols.
Topics: Acrolein; Aldehydes; Blood Proteins; Humans; Kinetics; Nitrogen Oxides; Oxidation-Reduction; Ozone; Smoking; Sulfhydryl Compounds; Sulfites; Thioctic Acid | 1995 |
Redox regulation of NF-kappa B DNA binding activity by dihydrolipoate.
Topics: Base Sequence; Cell Nucleus; Diamide; Dithiothreitol; DNA; DNA Probes; Ethers, Cyclic; Humans; Molecular Sequence Data; NF-kappa B; Okadaic Acid; Oxidation-Reduction; Thioctic Acid; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Using lipoate enantiomers and thioredoxin to study the mechanism of the 2-oxoacid-dependent dihydrolipoate production by the 2-oxoacid dehydrogenase complexes.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Biphenyl Compounds; Chemical Precipitation; Escherichia coli; Flavin-Adenine Dinucleotide; Insulin; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ketone Oxidoreductases; Multienzyme Complexes; NAD; Onium Compounds; Pyruvate Dehydrogenase Complex; Stereoisomerism; Thioctic Acid; Thioredoxins | 1995 |
Susceptibility of agar-entrapped Escherichia coli cultures to cefotaxime as assessed by the potentiometric measurement of lipoic acid reduction.
Topics: Agar; Biofilms; Cefotaxime; Culture Media; Escherichia coli; Microbial Sensitivity Tests; Oxidation-Reduction; Potentiometry; Thioctic Acid | 1994 |
Endogenous ascorbate regenerates vitamin E in the retina directly and in combination with exogenous dihydrolipoic acid.
Topics: Animals; Ascorbic Acid; Chromatography, High Pressure Liquid; Dehydroascorbic Acid; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Male; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Retina; Thioctic Acid; Ultraviolet Rays; Vitamin E | 1995 |
Determination of structure-antioxidant activity relationships of dihydrolipoic acid.
Topics: Animals; Antioxidants; Borohydrides; Dihydrolipoamide Dehydrogenase; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Myocardium; Structure-Activity Relationship; Swine; Thioctic Acid | 1994 |
Alpha-lipoic acid increases intracellular glutathione in a human T-lymphocyte Jurkat cell line.
Topics: Cell Line; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Glutathione; Humans; Kinetics; T-Lymphocytes; Thioctic Acid; Time Factors; Tumor Cells, Cultured | 1995 |
Phenoxyl radical-induced thiol-dependent generation of reactive oxygen species: implications for benzene toxicity.
Topics: Acridines; Benzene; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Deoxyguanosine; DNA; Electron Spin Resonance Spectroscopy; Glutathione; Horseradish Peroxidase; Hydrogen Peroxide; Luminescent Measurements; Monophenol Monooxygenase; Oxidation-Reduction; Peroxidase; Phenol; Phenols; Reactive Oxygen Species; Spin Labels; Sulfhydryl Compounds; Superoxides; Thioctic Acid | 1995 |
Alpha-lipoic acid supplementation prevents symptoms of vitamin E deficiency.
Topics: Animals; Body Weight; Diet; Kidney; Liver; Mice; Mice, Hairless; Myocardium; Skin; Thioctic Acid; Tissue Distribution; Vitamin E; Vitamin E Deficiency | 1994 |
alpha-Lipoic acid protects against hemolysis of human erythrocytes induced by peroxyl radicals.
Topics: Amidines; Ascorbic Acid; Cyclic N-Oxides; Drug Synergism; Electron Spin Resonance Spectroscopy; Erythrocytes; Free Radicals; Glutathione; Hemolysis; Humans; Methemoglobin; Oxidation-Reduction; Stereoisomerism; Structure-Activity Relationship; Thioctic Acid | 1994 |
Penetration of spin-labeled dihydrolipoate into the skin of hairless mice. Modification of epidermal and dermal polarity.
Topics: Animals; Dithionitrobenzoic Acid; Electron Spin Resonance Spectroscopy; Epidermis; Female; Image Processing, Computer-Assisted; Mice; Mice, Hairless; Skin Absorption; Spin Labels; Thioctic Acid | 1994 |
NMR study of lipoic acid binding to bovine serum albumin.
Topics: Animals; Caprylates; Cattle; Deuterium Oxide; Humans; Lipoproteins, LDL; Magnetic Resonance Spectroscopy; Protein Binding; Serum Albumin, Bovine; Thioctic Acid; Water | 1994 |
Antioxidant inhibition of skin inflammation induced by reactive oxidants: evaluation of the redox couple dihydrolipoate/lipoate.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Chromans; Dermatitis, Contact; Female; Mice; Mice, Hairless; Oxidation-Reduction; Random Allocation; Stereoisomerism; Superoxide Dismutase; Thioctic Acid | 1994 |
Ascorbate is the primary reductant of the phenoxyl radical of etoposide in the presence of thiols both in cell homogenates and in model systems.
Topics: Animals; Ascorbic Acid; Electron Spin Resonance Spectroscopy; Etoposide; Free Radicals; Liver; Male; Monophenol Monooxygenase; Oxidation-Reduction; Phenols; Rats; Rats, Sprague-Dawley; Retina; Subcellular Fractions; Sulfhydryl Compounds; Thioctic Acid | 1994 |
Aldehyde-induced protein modifications in human plasma: protection by glutathione and dihydrolipoic acid.
Topics: Adult; Aldehydes; Antioxidants; Ascorbic Acid; Glutathione; Humans; Lipid Peroxidation; Male; Middle Aged; Smoking; Sulfhydryl Compounds; Thioctic Acid; Vitamin E | 1994 |
The endogenous cofactors, thioctic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum.
Topics: Animals; Injections, Intraperitoneal; Male; Malonates; Mitochondria; N-Methylaspartate; Neostriatum; Rats; Rats, Sprague-Dawley; Thioctic Acid | 1994 |
The short-chain homologue of dihydrolipoic acid, tetranordihydrolipoate, protects against iron-induced lipid peroxidation in the aqueous phase.
Topics: In Vitro Techniques; Iron; Lipid Peroxides; Liposomes; Models, Chemical; Oxidation-Reduction; Oxygen Consumption; Thioctic Acid | 1994 |
Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates.
Topics: Ascorbic Acid; Cell Nucleus; Chromatography, High Pressure Liquid; Deferoxamine; Electron Spin Resonance Spectroscopy; Etoposide; Free Radicals; Glutathione; Humans; Leukemia; Monophenol Monooxygenase; Oxidation-Reduction; Phenols; Thioctic Acid; Tumor Cells, Cultured | 1993 |
Naturally occurring antibodies reacting with lipoic acid: screening method, characterization and biochemical interest.
Topics: Animals; Antibodies; Antibodies, Monoclonal; Antibody Specificity; Binding, Competitive; Blood Proteins; Cross Reactions; Disulfides; Enzyme-Linked Immunosorbent Assay; Female; Mice; Mice, Inbred BALB C; Microchemistry; Protein Binding; Serum Albumin, Bovine; Thioctic Acid | 1994 |
Effects of alpha-lipoic acid and dihydrolipoic acid on expression of proto-oncogene c-fos.
Topics: Base Sequence; Cell Line; Consensus Sequence; DNA; Gene Expression Regulation; Genes, fos; Humans; Kinetics; Protein Kinase C; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Reactive Oxygen Species; RNA, Messenger; T-Lymphocytes; Tetradecanoylphorbol Acetate; Thioctic Acid | 1994 |
Alpha-lipoic acid reduction by mammalian cells to the dithiol form, and release into the culture medium.
Topics: Chromatography, High Pressure Liquid; Culture Media; Electrodes; Humans; Oxidation-Reduction; Sulfhydryl Compounds; Thioctic Acid; Tumor Cells, Cultured | 1994 |
Allosteric modulation of the NMDA receptor by dihydrolipoic and lipoic acid in rat cortical neurons in vitro.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dithionitrobenzoic Acid; N-Methylaspartate; Neurons; Oxidation-Reduction; Rats; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Thioctic Acid | 1993 |
Cardiac recovery during post-ischemic reperfusion is improved by combination of vitamin E with dihydrolipoic acid.
Topics: Analysis of Variance; Animals; Biomarkers; Coronary Circulation; Food, Fortified; Hypoxia; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Myocardial Ischemia; Myocardium; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Thioctic Acid; Time Factors; Vitamin E | 1993 |
Antioxidant activities of dihydrolipoic acid and its structural homologues.
Topics: Animals; Antioxidants; Deferoxamine; Free Radical Scavengers; Free Radicals; Kinetics; Lipid Peroxidation; Microsomes, Liver; Molecular Structure; Rats; Solutions; Structure-Activity Relationship; Superoxides; Thioctic Acid | 1993 |
Dihydrolipoic acid prevents hypoxic/reoxygenation and peroxidative damage in rat heart mitochondria.
Topics: Animals; Cyclic N-Oxides; Diphenylhexatriene; Disulfides; Dithiothreitol; Electron Spin Resonance Spectroscopy; Fluorescence Polarization; Hydrogen Peroxide; Intracellular Membranes; Lipid Peroxidation; Male; Malondialdehyde; Membrane Fluidity; Mitochondria, Heart; Oxygen; Pyrrolidines; Rats; Rats, Inbred Strains; Rats, Wistar; Spin Labels; Thioctic Acid; Tiopronin | 1993 |
Dihydrolipoic acid protects pancreatic islet cells from inflammatory attack.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Free Radicals; Hypoxanthine; Hypoxanthines; Islets of Langerhans; Luminescent Measurements; Macrophage Activation; Macrophages; Nitric Oxide; Nitrites; Peritoneal Cavity; Rats; Rats, Wistar; Thioctic Acid; Xanthine Oxidase | 1993 |
Properties of Azotobacter vinelandii rhodanese.
Topics: Amino Acids; Azotobacter vinelandii; Chromatography, High Pressure Liquid; Cyanides; Electrophoresis, Polyacrylamide Gel; Kinetics; Molecular Weight; Thioctic Acid; Thiosulfate Sulfurtransferase; Thiosulfates | 1993 |
Cardioprotective efficiency of dihydrolipoic acid in working rat hearts during hypoxia and reoxygenation. 31P nuclear magnetic resonance investigations.
Topics: Adenosine Triphosphate; Animals; Creatine Kinase; Heart; Heart Diseases; Hypoxia; In Vitro Techniques; Indicators and Reagents; Magnetic Resonance Spectroscopy; Male; Mitochondria, Heart; Oxygen; Perfusion; Phosphates; Phosphocreatine; Rats; Rats, Wistar; Thioctic Acid | 1993 |
Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by oxidized and reduced lipoic acid.
Topics: alpha 1-Antitrypsin; Antioxidants; Free Radical Scavengers; Humans; In Vitro Techniques; Nitrates; Nitric Oxide; Oxidation-Reduction; Reactive Oxygen Species; Thioctic Acid; Tyrosine | 1996 |
The influence of vitamin E and dihydrolipoic acid on cardiac energy and glutathione status under hypoxia-reoxygenation.
Topics: Animals; Antioxidants; Energy Metabolism; Glutathione; Glutathione Disulfide; Heart; Hypoxia; Male; Myocardial Reperfusion; Myocardium; Oxidative Stress; Oxygen; Perfusion; Rats; Rats, Sprague-Dawley; Thioctic Acid; Vitamin E | 1995 |
Elucidation of antioxidant activity of dihydrolipoic acid toward hydroxyl radical using a novel hydroxyl radical generator NP-III.
Topics: Antioxidants; Apolipoproteins B; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Oxidation-Reduction; Serum Albumin, Bovine; Spin Trapping; Thioctic Acid; Ultraviolet Rays | 1995 |
Quenching of reactive oxidative species by probucol and comparison with other antioxidants.
Topics: Acetylcysteine; Antimutagenic Agents; Antioxidants; Ascorbic Acid; Benzophenones; Benzoquinones; Free Radicals; Oxidation-Reduction; Photolysis; Probucol; Reactive Oxygen Species; Spectrophotometry; Spectrum Analysis, Raman; Thioctic Acid; Vitamin E | 1996 |
Reevaluation of superoxide scavenging activity of dihydrolipoic acid and its analogues by chemiluminescent method using 2-methyl-6-[p-methoxyphenyl]-3,7-dihydroimidazo-[1,2-a]pyrazine-3-one (MCLA) as a superoxide probe.
Topics: Cysteine; Free Radical Scavengers; Imidazoles; Luminescent Measurements; Molecular Probes; Pyrazines; Superoxides; Thioctic Acid | 1996 |
2D NMR of the metabolic antioxidant dihydrolipoic acid and its derivatives.
Topics: Antioxidants; Cadmium Chloride; Carbon; Deuterium Oxide; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Protons; Solutions; Structure-Activity Relationship; Thioctic Acid | 1996 |
Decomposition of alpha-lipoic acid derivatives by photoirradiation-formation of dihydrolipoic acid from alpha-lipoic acid-.
Topics: Antioxidants; Ascorbic Acid; Disulfides; Free Radicals; Models, Chemical; Molecular Structure; Photochemistry; Photolysis; Reactive Oxygen Species; Serum Albumin; Spectrophotometry, Ultraviolet; Sulfhydryl Compounds; Thioctic Acid; Ultraviolet Rays | 1996 |
[Thionitrites as potent donors of nitric oxide: example of S-nitroso- and S,S'-dinitroso-dihydrolipoic acids].
Topics: Antioxidants; Drug Stability; Electron Spin Resonance Spectroscopy; Nitric Oxide; Nitroso Compounds; Thioctic Acid | 1996 |
Endogenous and exogenous regulation of redox-properties of coenzyme Q.
Topics: Antioxidants; Electron Spin Resonance Spectroscopy; Lipid Peroxidation; Lipoproteins, LDL; Liposomes; Oxidation-Reduction; Oxidative Stress; Peroxides; Photolysis; Thioctic Acid; Ubiquinone | 1997 |
Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization.
Topics: Animals; Cystine; Erythrocytes; Flow Cytometry; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Humans; Kinetics; Leukemia-Lymphoma, Adult T-Cell; Mice; Neuroblastoma; Neuroglia; Oxidation-Reduction; Rats; Thioctic Acid; Tumor Cells, Cultured | 1997 |
Determination of lipoic acid by precolumn derivatization with monobromobimane and reversed-phase high-performance liquid chromatography.
Topics: Animals; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Fluorescent Dyes; Humans; Myocardium; Rats; Sensitivity and Specificity; Spectrometry, Fluorescence; Thioctic Acid | 1998 |
The stimulation of the mitochondrial permeability transition by dihydrolipoate and alpha-lipoate.
Topics: Animals; Biological Transport; Cyclosporine; Intracellular Membranes; Liver; Male; Membrane Potentials; Mitochondria, Liver; Permeability; Rats; Rats, Wistar; Thioctic Acid | 1998 |
Antioxidant reactions of dihydrolipoic acid and lipoamide with triplet duroquinone.
Topics: Antioxidants; Benzoquinones; Free Radicals; Kinetics; Lasers; Photolysis; Spectrum Analysis, Raman; Thioctic Acid | 1998 |
Cardioprotective effects of dihydrolipoic acid and tocopherol in right heart hypertrophy during oxidative stress.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Calcium; Cardiomegaly; Coronary Circulation; Creatine Kinase; Free Radical Scavengers; Glutathione; Heart Function Tests; Male; Membrane Potentials; Mitochondria, Heart; Mitochondrial Swelling; Oxidative Stress; Perfusion; Rats; Rats, Wistar; Thioctic Acid; Vitamin E | 1998 |
Effects of dihydrolipoic acid on peptide methionine sulfoxide reductase. Implications for antioxidant drugs.
Topics: alpha 1-Antitrypsin; Animals; Antioxidants; Chromatography, Liquid; In Vitro Techniques; Lung; Male; Methionine Sulfoxide Reductases; Oxidoreductases; Rats; Rats, Wistar; Reducing Agents; Thioctic Acid | 1998 |
Thiol chelation of Cu2+ by dihydrolipoic acid prevents human low density lipoprotein peroxidation.
Topics: Chelating Agents; Copper; Electron Spin Resonance Spectroscopy; Free Radicals; Humans; Hydrogen-Ion Concentration; Kinetics; Lipid Peroxidation; Lipoproteins, LDL; Oxidation-Reduction; Sulfhydryl Compounds; Thioctic Acid | 1998 |
Determination of oxidized and reduced lipoic acid using high-performance liquid chromatography and coulometric detection.
Topics: Animals; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Jurkat Cells; Lymphocytes; Muscle, Skeletal; Oxidation-Reduction; Rats; Sulfhydryl Compounds; Thioctic Acid | 1999 |
Dihydrolipoic acid maintains ubiquinone in the antioxidant active form by two-electron reduction of ubiquinone and one-electron reduction of ubisemiquinone.
Topics: Animals; Antioxidants; Coenzymes; Cold Temperature; Cytoprotection; Electron Spin Resonance Spectroscopy; Electrons; Hydrogen-Ion Concentration; Mitochondria, Liver; Oxidation-Reduction; Rats; Spectrophotometry, Ultraviolet; Spectrum Analysis; Thioctic Acid; Ubiquinone | 1999 |
The inhibitory effects of lipoic compounds on mammalian pyruvate dehydrogenase complex and its catalytic components.
Topics: Acetyltransferases; Animals; Antioxidants; Dihydrolipoamide Dehydrogenase; Dihydrolipoyllysine-Residue Acetyltransferase; Humans; Kinetics; Mammals; Myocardium; Organoselenium Compounds; Pentanoic Acids; Pyruvate Dehydrogenase Complex; Recombinant Proteins; Stereoisomerism; Swine; Thioctic Acid; Tumor Cells, Cultured | 1999 |
Enhanced ADP-ribosylation and its diminution by lipoamide after ischemia-reperfusion in perfused rat heart.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Animals; Antioxidants; DNA Damage; Enzyme Activation; In Vitro Techniques; Lipid Peroxidation; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; NAD; Perfusion; Poly(ADP-ribose) Polymerases; Proteins; Rats; Rats, Wistar; Reactive Oxygen Species; Thioctic Acid | 1999 |
Determination of lipoic acid and dihydrolipoic acid in human plasma and urine by high-performance liquid chromatography with fluorimetric detection.
Topics: Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence; Thioctic Acid | 2000 |
A method for measuring disulfide reduction by cultured mammalian cells: relative contributions of glutathione-dependent and glutathione-independent mechanisms.
Topics: Animals; Arsenicals; Arsenites; Carmustine; CHO Cells; Cricetinae; Cystine; Diamide; Disulfides; Dithionitrobenzoic Acid; Glutathione; Humans; Oxidation-Reduction; Rats; Selenium Compounds; Selenium Oxides; Sulfhydryl Compounds; Thioctic Acid; Tumor Cells, Cultured | 2000 |
Mechanism of dihydrolipoate stimulation of the mitochondrial permeability transition: effect of different respiratory substrates.
Topics: Animals; Antioxidants; Calcium; Dose-Response Relationship, Drug; Glutathione; Ketoglutaric Acids; Mitochondria, Liver; Oxidation-Reduction; Oxygen Consumption; Pyridines; Pyruvic Acid; Rats; Reactive Oxygen Species; Spectrometry, Fluorescence; Thioctic Acid; Time Factors | 2000 |
Lipoic acid reduces ischemia-reperfusion injury in animal models.
Topics: Adenosine Triphosphatases; Animals; Creatine Kinase; Disease Models, Animal; Heart; Hindlimb; In Vitro Techniques; Male; Muscle Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Phosphocreatine; Rats; Rats, Sprague-Dawley; Thioctic Acid | 2000 |
Specific interaction of lipoate at the active site of rhodanese.
Topics: Binding Sites; Crystallography; Fluorescence; Models, Chemical; Models, Molecular; Oxidation-Reduction; Substrate Specificity; Sulfur; Thioctic Acid; Thiosulfate Sulfurtransferase | 2000 |
Ascorbate-dependent recycling of the vitamin E homologue Trolox by dihydrolipoate and glutathione in murine skin homogenates.
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Extracts; Chromans; Electron Spin Resonance Spectroscopy; Free Radicals; Glutathione; Hydrogen Peroxide; Kinetics; Mice; Peroxidase; Phenols; Skin; Thioctic Acid; Vitamin E | 2000 |
Synthesis and characterization of selenotrisulfide-derivatives of lipoic acid and lipoamide.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Dihydrolipoamide Dehydrogenase; Humans; Hydrogen-Ion Concentration; Molecular Structure; Oxidation-Reduction; Rats; Recombinant Proteins; Selenium Compounds; Sodium Selenite; Sulfides; Thioctic Acid; Thioredoxin-Disulfide Reductase | 2000 |
Regulation of the activity of choline acetyl transferase by lipoic acid.
Topics: Antioxidants; Choline O-Acetyltransferase; Enzyme Activation; Oxidation-Reduction; Thioctic Acid | 2000 |
Thiols can either enhance or suppress DNA damage induction by catecholestrogens.
Topics: Acetylcysteine; Antioxidants; Copper; Dithiothreitol; DNA Damage; Drug Resistance, Neoplasm; Estradiol; Estrogens, Catechol; Glutathione; Hydrogen Peroxide; Kinetics; Methotrexate; NAD; Oxidation-Reduction; Reactive Oxygen Species; Sulfhydryl Compounds; Thioctic Acid | 2001 |
Activity of alpha-lipoic acid in the protection against oxidative stress in skin.
Topics: Antioxidants; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Humans; Keratinocytes; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Solubility; Thioctic Acid; Ubiquinone; Ultraviolet Rays; Vitamin E | 2001 |
Bifunctional anti/prooxidant potential of metallothionenin: redox signaling of copper binding and release.
Topics: Animals; Antioxidants; Cadmium; Cell Survival; Copper; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; HL-60 Cells; Humans; Hydrogen Peroxide; Lipid Peroxidation; Liver; Luminol; Metallothionein; Oxidants; Oxidation-Reduction; Oxidative Stress; Protein Binding; Rabbits; Sulfhydryl Compounds; Thioctic Acid; Transfection | 1999 |
Coenzyme Q10, vitamin E, and dihydrothioctic acid cooperatively prevent diene conjugation in isolated low-density lipoprotein.
Topics: Antioxidants; Ascorbic Acid; Coenzymes; Copper; Humans; Ions; Lipoproteins, LDL; Male; Middle Aged; Models, Biological; Molsidomine; Nitric Oxide Donors; Oxygen; Protein Binding; Thioctic Acid; Time Factors; Ubiquinone; Vitamin E | 2000 |
Lipoate ameliorates ischemia-reperfusion in animal models.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Aorta, Thoracic; Cell Hypoxia; Constriction; Creatine Kinase; Drug Evaluation, Preclinical; Free Radical Scavengers; Hindlimb; Iliac Artery; Ischemia; Isoenzymes; Magnetic Resonance Spectroscopy; Male; Mitochondria, Heart; Muscle Contraction; Muscle Proteins; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidative Stress; Phosphocreatine; Rats; Rats, Wistar; Reperfusion Injury; Swine; Thioctic Acid | 2000 |
Sulfur-centered radical formation from the antioxidant dihydrolipoic acid.
Topics: Antioxidants; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Oxygen; Phenol; Spectrophotometry; Sulfhydryl Compounds; Sulfur; Superoxide Dismutase; Thioctic Acid | 2001 |
alpha-Lipoic acid prevents the development of glucose-induced insulin resistance in 3T3-L1 adipocytes and accelerates the decline in immunoreactive insulin during cell incubation.
Topics: 3T3 Cells; Acetylcysteine; Adipocytes; Animals; Antioxidants; Biological Transport; Culture Media, Conditioned; Dose-Response Relationship, Drug; Drug Synergism; Glucose; Insulin; Insulin Resistance; Mice; Oxidative Stress; Thioctic Acid | 2001 |
Activation of choline acetyl transferase by dihydrolipoic acid.
Topics: Animals; Brain; Choline O-Acetyltransferase; Enzyme Activation; Myocardium; Rabbits; Rats; Thioctic Acid; Urinary Bladder | 2002 |
Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid.
Topics: Antioxidants; Apoptosis; Ascorbic Acid; Caspase 3; Caspases; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; HL-60 Cells; Humans; Hydrogen Peroxide; Oxygen; Peroxidase; Thioctic Acid | 2002 |
Arsenate reductase II. Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems.
Topics: Animals; Antioxidants; Arsenite Transporting ATPases; Cattle; Chromatography; Drug Interactions; Electrophoresis; Humans; Ion Pumps; Liver; Male; Mass Spectrometry; Multienzyme Complexes; Purine-Nucleoside Phosphorylase; Thioctic Acid | 2002 |
Lipoyl dehydrogenase catalyzes reduction of nitrated DNA and protein adducts using dihydrolipoic acid or ubiquinol as the cofactor.
Topics: Dihydrolipoamide Dehydrogenase; Guanine; NADP; Nitrogen Oxides; Oxidation-Reduction; Reactive Nitrogen Species; Thioctic Acid; Tyrosine; Ubiquinone; Xanthines | 2002 |
Cofactors of mitochondrial enzymes attenuate copper-induced death in vitro and in vivo.
Topics: Animals; Apoptosis; Cell Death; Cells, Cultured; Cerebral Cortex; Copper; Embryo, Mammalian; Free Radical Scavengers; Hydroxyl Radical; Longevity; Mice; Neurons; Neuroprotective Agents; Rats; Rats, Long-Evans; Thiamine; Thioctic Acid | 2002 |
Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I.
Topics: Apolipoprotein A-I; Circular Dichroism; Dimyristoylphosphatidylcholine; Indicators and Reagents; Lipoproteins, HDL; Methionine Sulfoxide Reductases; Oxidation-Reduction; Oxidoreductases; Protein Binding; Protein Denaturation; Thioctic Acid | 2002 |
Cathepsin B responsiveness to glutathione and lipoic acid redox.
Topics: Animals; Antioxidants; Cathepsin B; Cattle; Cysteine Endopeptidases; Dinitrochlorobenzene; Dithiothreitol; Enzyme Activation; Glutathione; Heart; In Vitro Techniques; Molecular Structure; Myocardium; Oxidation-Reduction; Rats; Thioctic Acid | 2002 |
Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Catalysis; Coenzyme A; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Enzyme Activation; Flavin-Adenine Dinucleotide; Free Radicals; Ketone Oxidoreductases; Multienzyme Complexes; NAD; Nitrogen Oxides; Spin Labels; Superoxides; Thioctic Acid; Thioredoxins | 2002 |
Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate.
Topics: Animals; Antioxidants; Cattle; Drug Interactions; Free Radical Scavengers; Mitochondria, Heart; Mitochondria, Liver; Permeability; Rats; Reactive Oxygen Species; Thioctic Acid | 2003 |
Hemoprotein-mediated reduction of nitrated DNA bases in the presence of reducing agents.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Cytochromes c; Dithiothreitol; DNA; DNA Adducts; Glutathione; Hemoglobins; Humans; Nitrates; Oxidation-Reduction; Reducing Agents; Thioctic Acid; Time Factors | 2003 |
Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.
Topics: Antioxidants; Ascorbic Acid; Cell Survival; Chromans; Chromatography, High Pressure Liquid; Electron Spin Resonance Spectroscopy; Free Radicals; HL-60 Cells; Humans; Hydrogen Peroxide; Oxidation-Reduction; Peroxidase; Phenols; Spectrophotometry; Substrate Cycling; Thioctic Acid | 2003 |
Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation.
Topics: Animals; Arginine; Arterioles; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Maleimides; NADH, NADPH Oxidoreductases; NADPH Oxidases; Oxidative Stress; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spin Labels; Superoxides; Thioctic Acid; Vasodilation | 2003 |
Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2.
Topics: Amino Acid Sequence; Binding Sites; Catalytic Domain; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Glutaredoxins; Humans; Intramolecular Oxidoreductases; Kinetics; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oxidation-Reduction; Oxidative Stress; Oxidoreductases; Prostaglandin-E Synthases; Protein Binding; Protein Structure, Tertiary; Proteins; Serine; Thioctic Acid; Thioredoxins | 2003 |
In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones.
Topics: Animals; Antioxidants; Benzenesulfonates; Cell Survival; Cells, Cultured; Cyclic N-Oxides; Drug Synergism; Hydrogen Peroxide; In Vitro Techniques; Neurons; Neuroprotective Agents; Nitrogen Oxides; Oxidants; Oxidative Stress; Prosencephalon; Rats; Reactive Oxygen Species; Thioctic Acid | 2003 |
Inhibition of oxygen radical formation by methylene blue, aspirin, or alpha-lipoic acid, prevents bacterial-lipopolysaccharide-induced fever.
Topics: Animals; Antioxidants; Aspirin; Bacterial Infections; Brain; Catalase; Endotoxins; Female; Fever; Formazans; Hydrogen Peroxide; Injections, Intravenous; Lipopolysaccharides; Methylene Blue; Perfusion; Rabbits; Reactive Oxygen Species; Subarachnoid Space; Thioctic Acid; Tumor Necrosis Factor-alpha | 2003 |
The biological action of cobalt and other metals. III. Chelation of cations by dihydrolipoic acid.
Topics: Cadmium; Cations; Chelating Agents; Cobalt; Copper; Metals; Nickel; Thioctic Acid; Zinc | 1962 |
[STUDIES ON THE IMMUNIZATION OF HORSES BY HABU SNAKE VENOM TREATED BY FREUND'S ADJUVANT OR DIHYDROTHIOCTIC ACID].
Topics: Animals; Antivenins; Crotalid Venoms; Freund's Adjuvant; Horses; Immunization; Research; Snake Venoms; Sulfhydryl Compounds; Thioctic Acid; Trimeresurus; Vaccination; Venoms | 1965 |
Reduction of active sulfate (PAPS) by dihydrolipoic acid as substrate.
Topics: Ions; Sulfates; Thioctic Acid | 1960 |
On the reaction between dihydrolipoic acid and flavins: spectral changes induced by flavin-peroxide interaction.
Topics: Dinitrocresols; Flavins; Organic Chemicals; Peroxides; Thioctic Acid | 1962 |
Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation.
Topics: Acetylcysteine; Animals; Antioxidants; Arachidonate 15-Lipoxygenase; Dithionite; Free Radical Scavengers; Free Radicals; Glycine max; Humans; Linoleic Acid; Lipid Peroxidation; Lipoxygenase Inhibitors; Masoprocol; Rabbits; Reticulocytes; Thioctic Acid | 2003 |
Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.
Topics: Antioxidants; Dose-Response Relationship, Drug; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Hypochlorous Acid; Inhibitory Concentration 50; Isoenzymes; Models, Biological; Models, Chemical; Nitric Oxide; Oxygen; Peroxynitrous Acid; Potassium; Protein Binding; Rhodamines; Sulfur; Thioctic Acid; Tyrosine | 2004 |
Photoinduced interactions between oxidized and reduced lipoic acid and riboflavin (vitamin B2).
Topics: Antioxidants; Benzoquinones; Deuterium Oxide; Drug Interactions; Light; Oxidation-Reduction; Photochemistry; Photolysis; Reactive Nitrogen Species; Reactive Oxygen Species; Riboflavin; Spectrometry, Fluorescence; Thioctic Acid; Time Factors | 2004 |
Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes.
Topics: Aconitate Hydratase; Animals; Binding Sites; Cattle; Chelating Agents; Ditiocarb; Ferric Compounds; Histidine; Organometallic Compounds; Oxidation-Reduction; Protein Binding; Superoxide Dismutase; Thioctic Acid; Transition Elements | 2004 |
Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats.
Topics: Administration, Oral; Alanine Transaminase; Amino Acids; Ammonia; Animals; Antioxidants; Aspartate Aminotransferases; Bile Acids and Salts; Cats; Dogs; Dose-Response Relationship, Drug; Humans; Liver; Male; Maximum Tolerated Dose; Microscopy, Electron; Rats; Thioctic Acid; Tissue Distribution | 2004 |
Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat.
Topics: Animals; Antioxidants; Chlorides; Disease Models, Animal; Electroencephalography; Ferric Compounds; Male; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Thioctic Acid | 2004 |
Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis.
Topics: Antioxidants; Cell Count; Cell Line; Cell Movement; Dipeptides; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Developmental; Humans; Matrix Metalloproteinase 9; Protease Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Thioctic Acid | 2004 |
Effects of dietary antioxidant supplementation before and after oral acetaminophen challenge in cats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Biomarkers; Cats; Chromatography, High Pressure Liquid; Cysteine; Dietary Supplements; Drug Therapy, Combination; Female; Glutathione; Guanine; Lymphocyte Activation; Lymphocytes; Male; Methemoglobin; Thioctic Acid; Vitamin E | 2005 |
Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores.
Topics: Biotechnology; Cadmium Compounds; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; HeLa Cells; Humans; Hydrogen-Ion Concentration; Ligands; Nuclear Magnetic Resonance, Biomolecular; Organophosphorus Compounds; Polyethylene Glycols; Quantum Dots; Selenium Compounds; Sulfides; Thioctic Acid; Zinc Compounds | 2005 |
Thermodynamics of the As(III)-thiol interaction: arsenite and monomethylarsenite complexes with glutathione, dihydrolipoic acid, and other thiol ligands.
Topics: Arsenates; Arsenic; Arsenic Poisoning; Arsenites; Calorimetry; Cations; Dithiothreitol; Glutathione; Ligands; Organometallic Compounds; Succimer; Sulfhydryl Compounds; Thermodynamics; Thioctic Acid | 2005 |
alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation.
Topics: Angiogenesis Inhibitors; Apoptosis; Cell Line, Tumor; Cell Nucleus; Colonic Neoplasms; Cytosol; DNA Fragmentation; Humans; Immunoblotting; Lactates; Lactic Acid; Mitochondria; Nitrobenzoates; Oxidative Stress; Oxygen; Pyruvic Acid; Reactive Oxygen Species; Superoxides; Thioctic Acid; Time Factors | 2005 |
Inhibition of gelatinase B (matrix metalloproteinase-9) by dihydrolipoic acid.
Topics: Animals; Bronchoalveolar Lavage Fluid; Enzyme Inhibitors; Enzyme Precursors; Gelatinases; Humans; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Mice; Neutrophils; Pulmonary Fibrosis; Thioctic Acid | 2005 |
N-acetylcysteine decreases angiotensin II receptor binding in vascular smooth muscle cells.
Topics: Acetylcysteine; Animals; Antioxidants; Cell Membrane; Disulfides; Dose-Response Relationship, Drug; Green Fluorescent Proteins; Immunoblotting; Inositol Phosphates; Kinetics; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxygen; Phosphates; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Signal Transduction; Temperature; Thioctic Acid; Time Factors; Vitamin E | 2005 |
Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid.
Topics: Antioxidants; Carbonates; Chromatography, High Pressure Liquid; Computer Simulation; Dimerization; Dose-Response Relationship, Drug; Free Radicals; Kinetics; Liposomes; Nitric Oxide; Nitrogen Dioxide; Oxygen; Peroxynitrous Acid; Sulfhydryl Compounds; Temperature; Thioctic Acid; Tyrosine | 2005 |
Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid.
Topics: Biological Availability; Glucose; Humans; Lysosomes; Mitochondria; Proteins; Reactive Oxygen Species; Thioctic Acid | 2006 |
Thioredoxin and dihydrolipoic acid inhibit elastase activity in cystic fibrosis sputum.
Topics: Adult; Animals; Child; Cystic Fibrosis; Enzyme Inhibitors; Escherichia coli Proteins; Humans; In Vitro Techniques; Leukocyte Elastase; Rats; Recombinant Proteins; Sputum; Thioctic Acid; Thioredoxins | 2005 |
Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols.
Topics: Caspase 3; Caspases; Catalysis; Electron Spin Resonance Spectroscopy; HeLa Cells; Humans; Hydroxylamine; Molecular Weight; Mutation; Nitric Oxide; Nitrogen Oxides; Nitrosation; Nitroso Compounds; Potentiometry; Proteins; S-Nitrosoglutathione; S-Nitrosothiols; Serum Albumin, Bovine; Sodium Nitrite; Thioctic Acid; Thioredoxin-Disulfide Reductase; Thioredoxins | 2005 |
The photochemistry of lipoic acid: photoionization and observation of a triplet excited state of a disulfide.
Topics: Acetone; Antioxidants; Cyclization; Disulfides; Free Radicals; Lasers; Molecular Structure; Oxidation-Reduction; Photolysis; Thioctic Acid; Time Factors; Ultraviolet Rays | 2005 |
Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro.
Topics: Amyloid; Amyloid beta-Peptides; Benzothiazoles; Masoprocol; Microscopy, Electron; Rifampin; Spectrometry, Fluorescence; Tetracycline; Thiazoles; Thioctic Acid | 2006 |
Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging.
Topics: Animals; Arsenicals; Blood Proteins; Cadmium; Diagnostic Imaging; Fluorescent Dyes; Indium; Microscopy, Electron, Transmission; Nanostructures; Polyethylene Glycols; Protein Binding; Quantum Dots; Rats; Selenium Compounds; Semiconductors; Sentinel Lymph Node Biopsy; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared; Thioctic Acid; Zinc Compounds | 2006 |
Evidence for covalent lipoyl adduction with dopaquinone following tyrosinase-catalyzed oxidation.
Topics: Benzoquinones; Catalysis; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Monophenol Monooxygenase; Oxidation-Reduction; Thioctic Acid | 2006 |
Effects of lipoic acid and dihydrolipoic acid on 4-aminophenol-mediated erythrocytic toxicity in vitro.
Topics: Adult; Aminophenols; Diazonium Compounds; Drug Antagonism; Erythrocytes; Humans; Maleates; Thioctic Acid; Time Factors | 2006 |
Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Fluids; Circular Dichroism; Edema; Enzyme Inhibitors; Hindlimb; Humans; In Vitro Techniques; Mice; Phospholipases A; Phospholipases A2; Protein Structure, Secondary; Snake Venoms; Thioctic Acid | 2006 |
Effects of lipoic acid and dihydrolipoic acid on total erythrocytic thiols under conditions of restricted glucose in vitro.
Topics: Adult; Cells, Cultured; Diabetes Mellitus; Erythrocytes; Humans; Hypoglycemia; Methemoglobin; Sulfhydryl Compounds; Thioctic Acid | 2007 |
Effects of glutathione and N-acetyl cysteine on the antimycobacterial efficacy of isoniazid on Mycobacterium fortuitum in vitro.
Topics: Acetylcysteine; Antioxidants; Drug Interactions; Glutathione; Isoniazid; Microbial Sensitivity Tests; Mycobacterium fortuitum; Sulfhydryl Compounds; Thioctic Acid | 2006 |
Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drug Interactions; Female; Inflammation; Lipopolysaccharides; Mice; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Skin Neoplasms; Tetradecanoylphorbol Acetate; Thioctic Acid | 2007 |
Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands.
Topics: Amines; Biotin; Ligands; Molecular Structure; Optics and Photonics; Polyethylene Glycols; Quantum Dots; Solubility; Surface Properties; Thioctic Acid; Water | 2007 |
Is dihydrolipoic acid among the reductive activators of parasite CysHis proteases?
Topics: Animals; Antioxidants; Cathepsin B; Cysteine; Cysteine Endopeptidases; Dithiothreitol; Enzyme Activation; Enzyme Reactivators; Glutathione; Histidine; Iron; Mammals; Oxidation-Reduction; Plasmodium falciparum; Protozoan Proteins; Thioctic Acid; Trypanosoma cruzi | 2008 |
Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols.
Topics: Cysteine; Drug Carriers; Fluoroscopy; Glutathione; Gold; Intracellular Space; Ligands; Metal Nanoparticles; Sulfhydryl Compounds; Surface Properties; Thioctic Acid | 2008 |
Synthesis and anticancer properties of water-soluble zinc ionophores.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Ionophores; Mice; Models, Biological; Models, Molecular; Neoplasms; Oligonucleotide Array Sequence Analysis; Pyridines; Solubility; Thioctic Acid; Thiones; Tumor Cells, Cultured; Water; Xenograft Model Antitumor Assays; Zinc | 2008 |
Experimental determination of quantum dot size distributions, ligand packing densities, and bioconjugation using analytical ultracentrifugation.
Topics: Ligands; Microscopy, Electron, Transmission; Polyethylene Glycols; Quantum Dots; Spectrophotometry, Ultraviolet; Spectroscopy, Near-Infrared; Thioctic Acid; Ultracentrifugation | 2008 |
Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia.
Topics: Adaptation, Physiological; Animals; Antioxidants; Cell Membrane Permeability; Chromans; Erythrocytes; Heart; Humans; Male; Myocardial Reperfusion Injury; Myocardium; Potassium; Rats; Rats, Wistar; Superoxides; Thioctic Acid | 2009 |
Dihydrolipoic acid inhibits tetrachlorohydroquinone-induced tumor promotion through prevention of oxidative damage.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Apoptosis; Blotting, Western; Carcinogens; Caspases; Cell Survival; Comet Assay; Epididymis; Flow Cytometry; Hydroquinones; Immunohistochemistry; Male; Mice; Mitogen-Activated Protein Kinases; NIH 3T3 Cells; Oxidative Stress; Proliferating Cell Nuclear Antigen; Reactive Oxygen Species; Signal Transduction; Skin Neoplasms; Thioctic Acid | 2008 |
Polyethylene glycol-based bidentate ligands to enhance quantum dot and gold nanoparticle stability in biological media.
Topics: Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Gold; Ligands; Metal Nanoparticles; Nanotechnology; Polyethylene Glycols; Quantum Dots; Thioctic Acid | 2009 |
Multifunctional ligands based on dihydrolipoic acid and polyethylene glycol to promote biocompatibility of quantum dots.
Topics: Azides; Biocompatible Materials; Biotin; Fluorescent Dyes; Ligands; Nanotechnology; Polyethylene Glycols; Quantum Dots; Thioctic Acid | 2009 |
Effect of alpha lipoic acid on the tardive dyskinesia and oxidative stress induced by haloperidol in rats.
Topics: Animals; Antioxidants; Antipsychotic Agents; Brain; Catalepsy; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Free Radicals; Haloperidol; Lipid Peroxidation; Male; Oxidative Stress; Rats; Rats, Wistar; Reactive Nitrogen Species; Reactive Oxygen Species; Thioctic Acid; Treatment Outcome | 2009 |
Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells.
Topics: Caspase 3; Cell Line, Tumor; Enzyme Activation; Humans; Nitric Oxide; Thioctic Acid; Thioredoxin-Disulfide Reductase | 2009 |
The effect of biothiol on UV irradiated alpha-lipoic acid.
Topics: Antioxidants; Homocysteine; Thioctic Acid; Ultraviolet Rays | 2008 |
Polyvalent display and packing of peptides and proteins on semiconductor quantum dots: predicted versus experimental results.
Topics: Electrophoresis, Agar Gel; Models, Molecular; Peptides; Proteins; Quantum Dots; Semiconductors; Thioctic Acid | 2010 |
Small and stable sulfobetaine zwitterionic quantum dots for functional live-cell imaging.
Topics: Betaine; Cell Line; Cell Survival; Humans; Ligands; Microscopy, Fluorescence; Molecular Imaging; Particle Size; Quantum Dots; Receptor, Cannabinoid, CB1; Surface Properties; Thioctic Acid | 2010 |
Alpha-lipoic acid supplementation: a tool for obesity therapy?
Topics: Adolescent; Adult; Antioxidants; Blood Pressure; Body Mass Index; Body Weight; Dietary Supplements; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Obesity; Oxidation-Reduction; Reactive Oxygen Species; Thioctic Acid; Young Adult | 2010 |
Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acrolein; alpha-Tocopherol; Antioxidants; Ascorbic Acid; Catechin; Deoxyguanosine; DNA Damage; Docosahexaenoic Acids; Lipid Peroxidation; Thioctic Acid | 2010 |
Effects of DHLA-capped CdSe/ZnS quantum dots on the fibrillation of human serum albumin.
Topics: 8,11,14-Eicosatrienoic Acid; Cadmium Compounds; Humans; Kinetics; Models, Molecular; Particle Size; Protein Multimerization; Protein Structure, Quaternary; Protein Structure, Tertiary; Quantum Dots; Selenium Compounds; Semiconductors; Serum Albumin; Spectrum Analysis; Sulfides; Thioctic Acid; Zinc Compounds | 2010 |
Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia?
Topics: Antioxidants; Dopamine; Glutathione; Glutathione Disulfide; Humans; Mitochondria; Mitochondrial Membranes; Niacinamide; Schizophrenia; Thioctic Acid | 2010 |
Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Calcium Signaling; Cyclic AMP; Dinoprostone; Egtazic Acid; HEK293 Cells; Humans; Killer Cells, Natural; Leukocytes, Mononuclear; Receptors, G-Protein-Coupled; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Thioctic Acid | 2011 |
Water-soluble semiconductor nanocrystals cap exchanged with metalated ligands.
Topics: Cadmium Compounds; Chemical Precipitation; Hydrophobic and Hydrophilic Interactions; Ligands; Methanol; Models, Molecular; Molecular Conformation; Nanoparticles; Organophosphonates; Selenium Compounds; Semiconductors; Solubility; Sulfhydryl Compounds; Sulfides; Thioctic Acid; Water; Zinc; Zinc Compounds | 2011 |
α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β.
Topics: Animals; Antioxidants; Becaplermin; Biomarkers; Cell Line; Cell Proliferation; Cytokines; Gene Expression Regulation; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Male; MAP Kinase Signaling System; Oxidative Stress; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Wistar; Reactive Oxygen Species; Recombinant Proteins; RNA, Messenger; Thioctic Acid; Transforming Growth Factor beta | 2011 |
Impact of dihydrolipoic acid on mouse embryonic stem cells and related regulatory mechanisms.
Topics: Animals; Antioxidants; Apoptosis; Calcium; Caspase 3; Caspase 9; Embryonic Stem Cells; Membrane Potential, Mitochondrial; Mice; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species; Thioctic Acid | 2013 |
Surface-engineered quantum dots for the labeling of hydrophobic microdomains in bacterial biofilms.
Topics: 3-Mercaptopropionic Acid; Bacterial Physiological Phenomena; Biofilms; Cadmium Compounds; Diffusion; Hydrophobic and Hydrophilic Interactions; Leucine; Light; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Molecular Structure; Particle Size; Phenylalanine; Photoelectron Spectroscopy; Polytetrafluoroethylene; Quantum Dots; Scattering, Radiation; Selenium Compounds; Shewanella; Spectrometry, Fluorescence; Staining and Labeling; Static Electricity; Sulfides; Surface Tension; Thioctic Acid; Zinc Compounds | 2011 |
Simultaneous determination of lipoic acid (LA) and dihydrolipoic acid (DHLA) in human plasma using high-performance liquid chromatography coupled with electrochemical detection.
Topics: Adult; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Stability; Electrochemical Techniques; Humans; Methylene Chloride; Oxidative Stress; Reproducibility of Results; Sensitivity and Specificity; Thioctic Acid | 2011 |
Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles.
Topics: Animals; Biological Transport; Cell-Penetrating Peptides; Chlorocebus aethiops; Coated Materials, Biocompatible; COS Cells; Drug Design; Gold; Histidine; Hydrodynamics; Hydrogen-Ion Concentration; Ligands; Luminescent Agents; Metal Nanoparticles; Polyethylene Glycols; Quantum Dots; Recombinant Proteins; Salts; Semiconductors; Thioctic Acid; Wettability | 2011 |
Single-molecule colocalization studies shed light on the idea of fully emitting versus dark single quantum dots.
Topics: Cadmium Compounds; Darkness; Fluorescein-5-isothiocyanate; Fluorescence; Luminescent Measurements; Maltose-Binding Proteins; Peptides; Quantum Dots; Selenium Compounds; Streptavidin; Sulfides; Thioctic Acid; Zinc Compounds | 2011 |
Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide.
Topics: Animals; Brain; Cell Line, Tumor; HEK293 Cells; Humans; Hydrogen Sulfide; Mice; Mice, Inbred C57BL; Mitochondria; Sulfurtransferases; Thioctic Acid; Thioredoxins | 2011 |
Continuous-flow reactor-based synthesis of carbohydrate and dihydrolipoic acid-capped quantum dots.
Topics: Acetylation; Carbohydrates; Mannose; Nanotechnology; Quantum Dots; Sulfides; Temperature; Thioctic Acid; Zinc Compounds | 2011 |
Quantum-chemical investigation of the structure and the antioxidant properties of α-lipoic acid and its metabolites.
Topics: Antioxidants; Computer Simulation; Models, Chemical; Quantum Theory; Thioctic Acid | 2012 |
Poly(ethylene glycol)-based multidentate oligomers for biocompatible semiconductor and gold nanocrystals.
Topics: Biocompatible Materials; Gold; Ligands; Metal Nanoparticles; Polyethylene Glycols; Quantum Dots; Semiconductors; Solubility; Sulfides; Thioctic Acid; Zinc Compounds | 2012 |
Colloidal stability of gold nanoparticles modified with thiol compounds: bioconjugation and application in cancer cell imaging.
Topics: Colloids; Cystamine; Cysteine; Diagnostic Imaging; Glutathione; Gold; Humans; Metal Nanoparticles; Nanotechnology; Thioctic Acid | 2012 |
Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein.
Topics: Animals; Biosensing Techniques; Cattle; Color; Escherichia coli; Gold; Humans; Limit of Detection; Metal Nanoparticles; Prions; Sodium Chloride; Spectrophotometry; Thioctic Acid | 2012 |
Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells.
Topics: Animals; Betaine; Cytoplasm; Electroporation; Embryo, Nonmammalian; HeLa Cells; Humans; Microinjections; Quantum Dots; Thioctic Acid; Xenopus laevis | 2012 |
On the pH-dependent quenching of quantum dot photoluminescence by redox active dopamine.
Topics: Dopamine; Electrochemistry; Hydrogen-Ion Concentration; Luminescent Measurements; Optical Phenomena; Oxidation-Reduction; Oxygen; Polyethylene Glycols; Quantum Dots; Thioctic Acid | 2012 |
Microwave-assisted rapid synthesis of luminescent gold nanoclusters for sensing Hg2+ in living cells using fluorescence imaging.
Topics: Apoptosis; Fluorescent Dyes; Gold; HeLa Cells; Humans; Ions; Mercury; Metal Nanoparticles; Microscopy, Confocal; Microwaves; Thioctic Acid | 2012 |
Dihydrolipoic acid induces cytotoxicity in mouse blastocysts through apoptosis processes.
Topics: Animals; Apoptosis; Blastocyst; Cell Proliferation; Embryo Implantation; Embryo Transfer; Embryonic Development; Female; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Pregnancy; Thioctic Acid | 2012 |
Dihydrolipoic acid reduces cytochrome b561 proteins.
Topics: Amino Acid Sequence; Animals; Antioxidants; Arabidopsis; Ascorbic Acid; Cattle; Cytochrome b Group; Mice; Molecular Sequence Data; Oxidation-Reduction; Thioctic Acid | 2013 |
Polychlorinated biphenyl quinone metabolites lead to oxidative stress in HepG2 cells and the protective role of dihydrolipoic acid.
Topics: Antioxidants; Catalase; Cell Survival; Environmental Pollutants; Glutathione; Halogenation; Hep G2 Cells; Humans; Oxidative Stress; Polychlorinated Biphenyls; Quinones; Reactive Oxygen Species; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Thioctic Acid | 2012 |
Gold nanoparticles as a probe for prion determination via resonance light scattering method.
Topics: Gold; Light; Metal Nanoparticles; Particle Size; Prions; Scattering, Radiation; Surface Properties; Thioctic Acid | 2012 |
Impact of gold nanoparticle coating on redox homeostasis.
Topics: Animals; Apoptosis; Cell Line; Citric Acid; Glutathione; Gold; Homeostasis; Macrophages; Metal Nanoparticles; Oxidation-Reduction; Oxidative Stress; Rats; Reactive Oxygen Species; S-Nitrosoglutathione; Serum Albumin, Bovine; Surface Properties; Thioctic Acid | 2012 |
Role of gold nanoparticles capping density on stability and surface reactivity to design drug delivery platforms.
Topics: Diffusion; Drug Design; Drug Stability; Gold; Metal Nanoparticles; Nanocapsules; Surface Properties; Thioctic Acid | 2012 |
Robust photogeneration of H2 in water using semiconductor nanocrystals and a nickel catalyst.
Topics: Cadmium Compounds; Catalysis; Hydrogen; Nickel; Photochemical Processes; Quantum Dots; Selenium Compounds; Thioctic Acid; Water | 2012 |
Synthesis and bioactivity profile of 5-s-lipoylhydroxytyrosol-based multidefense antioxidants with a sizeable (poly)sulfide chain.
Topics: Antioxidants; Cell Survival; Hep G2 Cells; Humans; Molecular Structure; Oxidation-Reduction; Phenylethyl Alcohol; Thioctic Acid | 2013 |
Chemistry of conjugation to gold nanoparticles affects G-protein activity differently.
Topics: Animals; Circular Dichroism; Gold; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Kinetics; Metal Nanoparticles; Nucleotides; Protein Conformation; Rats; Spectrometry, Fluorescence; Thioctic Acid | 2013 |
Interaction of 9,10-phenanthraquinone with dithiol causes oxidative modification of Cu,Zn-superoxide dismutase (SOD) through redox cycling.
Topics: Catalytic Domain; Cells, Cultured; Copper; Dose-Response Relationship, Drug; Free Radicals; Humans; Hydrogen Peroxide; Isoenzymes; Oxidation-Reduction; Phenanthrenes; Protein Carbonylation; Superoxide Dismutase; Thioctic Acid; Toluene; Vehicle Emissions | 2013 |
Reduction of aggregation of β-lactoglobulin during heating by dihydrolipoic acid.
Topics: Animals; Cattle; Dithionitrobenzoic Acid; Ethylmaleimide; Heating; Lactoglobulins; Milk; Milk Proteins; Protein Denaturation; Thioctic Acid; Whey Proteins | 2013 |
Synthesis of new lipoic acid conjugates and evaluation of their free radical scavenging and neuroprotective activities.
Topics: Cell Line, Tumor; Cell Survival; Free Radical Scavengers; Humans; Molecular Structure; Neuroprotective Agents; Thioctic Acid | 2014 |
Stability of a liposomal formulation containing lipoyl or dihydrolipoyl acylglycerides.
Topics: Acylation; Administration, Cutaneous; Antioxidants; Delayed-Action Preparations; Dermatologic Agents; Drug Carriers; Drug Compounding; Drug Stability; Drug Storage; Glycerides; Liposomes; Phosphatidylcholines; Thioctic Acid | 2014 |
Lipoic acid and dihydrolipoic acid. A comprehensive theoretical study of their antioxidant activity supported by available experimental kinetic data.
Topics: Free Radical Scavengers; Free Radicals; Hydrogen Bonding; Kinetics; Models, Molecular; Protons; Thioctic Acid; Water | 2014 |
Quantitative measurement of proteolytic rates with quantum dot-peptide substrate conjugates and Förster resonance energy transfer.
Topics: Amino Acid Sequence; Animals; Calibration; Cattle; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Glutathione; Kinetics; Molecular Sequence Data; Peptide Hydrolases; Peptides; Proteolysis; Quantum Dots; Thioctic Acid | 2014 |
Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts.
Topics: Adult; Blotting, Western; Cells, Cultured; Collagen Type I; Dermis; Female; Fibroblasts; Gene Expression; Humans; Male; Matrix Metalloproteinases; Middle Aged; Oxidative Stress; Phosphorylation; Plasminogen Activator Inhibitor 1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Receptors, Platelet-Derived Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Scleroderma, Diffuse; Sulfurtransferases; Thioctic Acid; Tissue Inhibitor of Metalloproteinases | 2014 |
Simultaneous determination of the endogenous free α-lipoic acid and dihydrolipoic acid in human plasma and erythrocytes by RP-HPLC coupled with electrochemical detector.
Topics: Calibration; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Electrochemical Techniques; Erythrocytes; Humans; Hydrodynamics; Reference Standards; Reproducibility of Results; Solutions; Solvents; Specimen Handling; Thioctic Acid | 2015 |
[Comparative antioxidant action on the level of reactive oxygen species in normal and transformed fibroblasts].
Topics: Acetylcysteine; Animals; Antioxidants; Cell Line, Transformed; Fluoresceins; Fluorescent Dyes; Hydrogen Peroxide; Mice; NIH 3T3 Cells; Reactive Oxygen Species; Thioctic Acid | 2013 |
Accumulation of oxidized peroxiredoxin 2 in red blood cells and its prevention.
Topics: Acetylcysteine; Adenine; Adolescent; Adult; Aged; Antioxidants; Blood Preservation; Buffers; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Female; Glucose; Glutathione; Humans; Hydrogen Peroxide; Inosine; Male; Middle Aged; Oxidation-Reduction; Peroxiredoxins; Phosphates; Pyruvic Acid; Solutions; Sulfhydryl Compounds; Thioctic Acid; Young Adult | 2015 |
Dihydrolipoic but not alpha-lipoic acid affects susceptibility of eukaryotic cells to bacterial invasion.
Topics: Base Sequence; beta Catenin; Cadherins; Cell Line, Tumor; DNA Primers; Escherichia coli; Eukaryotic Cells; Humans; Real-Time Polymerase Chain Reaction; Serratia; Thioctic Acid | 2015 |
Quantum dot assisted tracking of the intracellular protein Cyclin E in Xenopus laevis embryos.
Topics: Animals; Cyclin E; Embryo, Nonmammalian; Green Fluorescent Proteins; Histidine; Microscopy, Electron, Transmission; Molecular Imaging; Quantum Dots; Recombinant Proteins; Sulfides; Thioctic Acid; Xenopus laevis; Zinc Compounds | 2015 |
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction.
Topics: Animals; Antineoplastic Agents, Alkylating; Autophagy; Colorectal Neoplasms; Cysteine; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Female; Glutathione; Guanine; HCT116 Cells; Humans; Male; Mice, Inbred BALB C; Molecular Targeted Therapy; Temozolomide; Thioctic Acid; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Plasma Metabolic Profiles in Women are Menopause Dependent.
Topics: Adult; Aged; Carnitine; Chromatography, High Pressure Liquid; Dehydroepiandrosterone Sulfate; Discriminant Analysis; Fatty Acids; Female; Humans; Lipid Metabolism; Lysophosphatidylcholines; Lysophospholipids; Menopause; Metabolome; Metabolomics; Middle Aged; Phenylacetates; Postmenopause; Pregnanediol; Premenopause; Thioctic Acid | 2015 |
Mapping the response of human fibroblast growth factor 21 (FGF21) promoter to serum availability and lipoic acid in HepG2 hepatoma cells.
Topics: Fibroblast Growth Factors; Hep G2 Cells; Histones; Humans; Promoter Regions, Genetic; Serum; Thioctic Acid | 2016 |
NIR-emitting chiral gold nanoclusters coated with γ-cyclodextrin are pH sensitive: Application as biomarker.
Topics: Biomarkers, Tumor; Cell Tracking; Cellular Microenvironment; Early Detection of Cancer; gamma-Cyclodextrins; Gold; Humans; Hydrogen-Ion Concentration; Metal Nanoparticles; Neoplasms; Thioctic Acid | 2016 |
A convenient purification method for silver nanoclusters and its applications in fluorescent pH sensors for bacterial monitoring.
Topics: Bacterial Typing Techniques; Colorimetry; Equipment Design; Equipment Failure Analysis; Escherichia coli K12; Fluorescent Dyes; Fractional Precipitation; Hydrogen-Ion Concentration; Luminescent Measurements; Metal Nanoparticles; Reproducibility of Results; Sensitivity and Specificity; Silver; Spectrometry, Fluorescence; Thioctic Acid | 2016 |
Lipoic Acid as a Possible Pharmacological Source of Hydrogen Sulfide/Sulfane Sulfur.
Topics: Animals; Catalysis; Edetic Acid; Hydrogen Sulfide; Hydrogen-Ion Concentration; Kidney; Liver; Male; Rats; Sulfur Compounds; Thioctic Acid; Time Factors | 2017 |
Nitric oxide induces monosaccharide accumulation through enzyme S-nitrosylation.
Topics: Adenosine Diphosphate Glucose; Adenosine Triphosphate; Arabidopsis; ATP Synthetase Complexes; Glycolysis; Monosaccharides; Mutation; Nitric Oxide; Nitrosation; Oxidation-Reduction; Phenotype; Plant Development; Plant Roots; Plant Shoots; Pyruvate Dehydrogenase Complex; Solubility; Starch; Sucrose; Thioctic Acid; Uridine Diphosphate Glucose | 2017 |
Assessment of the removal of side nanoparticulated populations generated during one-pot synthesis by asymmetric flow field-flow fractionation coupled to elemental mass spectrometry.
Topics: Antibodies; Chemistry Techniques, Analytical; Fractionation, Field Flow; Hydrophobic and Hydrophilic Interactions; Ligands; Mass Spectrometry; Nanoparticles; Quantum Dots; Thioctic Acid | 2017 |
Sensitive prostate specific antigen quantification using dihydrolipoic acid surface-functionalized phosphorescent quantum dots.
Topics: Cell Line, Tumor; Culture Media; Humans; Immunoassay; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Quantum Dots; Sulfides; Thioctic Acid; Zinc Compounds | 2017 |
Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational study.
Topics: Abortion, Spontaneous; Administration, Oral; Adolescent; Adult; Antioxidants; Apgar Score; Birth Weight; Dietary Supplements; Female; Gestational Age; Humans; Infant, Newborn; Pregnancy; Premature Birth; Retrospective Studies; Thioctic Acid; Young Adult | 2017 |
Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Lysosomal Membrane Proteins; Lysosomes; Male; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Thioctic Acid | 2018 |
INACTIVATION OF ALDEHYDE DEHYDROGENASE BY NITROGLYCERIN IN THE PRESENCE AND ABSENCE OF LIPOIC ACID AND DIHYDROLIPOIC ACID. IMPLICATIONS FOR THE PROBLEM OF DIFFERENTIAL EFFECTS OF LIPOIC ACID IN VITRO AND IN VIVO.
Topics: Aldehyde Dehydrogenase; Animals; Liver; Male; Nitroglycerin; Rats; Rats, Wistar; Thioctic Acid; Vasodilator Agents | 2016 |
Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase.
Topics: Agaricales; Caffeic Acids; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Melanins; Melanoma; Monophenol Monooxygenase; Pyrones; Skin Lightening Preparations; Thioctic Acid; Tyrosine 3-Monooxygenase | 2018 |
Alpha-lipoic acid, but not di-hydrolipoic acid, activates Nrf2 response in primary human umbilical-vein endothelial cells and protects against TNF-α induced endothelium dysfunction.
Topics: Antioxidants; Caspase 3; Human Umbilical Vein Endothelial Cells; Humans; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; NF-kappa B p50 Subunit; Signal Transduction; Thioctic Acid; Tumor Necrosis Factor-alpha | 2018 |
High Drug Loading, Reversible Disulfide Core-Cross-Linked Multifunctional Micelles for Triggered Release of Camptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cross-Linking Reagents; Drug Carriers; Drug Compounding; Drug Liberation; Drug Screening Assays, Antitumor; Drug Stability; Glutathione; Hep G2 Cells; Humans; MCF-7 Cells; Micelles; Nanoparticles; Neoplasms; Particle Size; Polyethylene Glycols; Thioctic Acid | 2018 |
Inactivation of Aldehyde Dehydrogenase by Disulfiram in the Presence and Absence of Lipoic Acid or Dihydrolipoic Acid: An in Vitro Study.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Aldehyde Dehydrogenase; Animals; Disulfiram; Liver; Male; Molecular Structure; Rats; Rats, Wistar; Saccharomyces cerevisiae; Thioctic Acid | 2019 |
Elucidating the Role of Surface Coating in the Promotion or Prevention of Protein Corona around Quantum Dots.
Topics: Hydrophobic and Hydrophilic Interactions; Protein Corona; Quantum Dots; Serum Albumin, Bovine; Surface Properties; Thioctic Acid | 2019 |
Dihydrolipoic Acid-Gold Nanoclusters Regulate Microglial Polarization and Have the Potential To Alter Neurogenesis.
Topics: Animals; Cell Line, Tumor; Cell Polarity; Gold; Metal Nanoparticles; Mice; Microglia; Neurogenesis; Neurons; Thioctic Acid | 2020 |
Regulatory effects of dihydrolipoic acid against inorganic mercury-mediated cytotoxicity and intrinsic apoptosis in PC12 cells.
Topics: Animals; Antioxidants; Apoptosis; Cell Survival; DNA Damage; Environmental Pollutants; Glutathione; Mercury; PC12 Cells; Rats; Signal Transduction; Thioctic Acid | 2020 |
Photon induced quantum yield regeneration of cap-exchanged CdSe/CdS quantum rods for ratiometric biosensing and cellular imaging.
Topics: Biosensing Techniques; Biotin; Cadmium Compounds; Cell Line, Tumor; Fluorescence Resonance Energy Transfer; Humans; Ligands; Light; Microscopy, Fluorescence; Photons; Quantum Dots; Selenium Compounds; Small Ubiquitin-Related Modifier Proteins; Sulfides; Thioctic Acid; Ultraviolet Rays | 2020 |
Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Heme Oxygenase (Decyclizing); Illness Behavior; Inflammation; Lipopolysaccharides; Male; NF-E2-Related Factor 2; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Signal Transduction; Thioctic Acid | 2020 |
Thermodynamics, Kinetics and Mechanisms of Noncompetitive Allosteric Inhibition of Chymotrypsin by Dihydrolipoic Acid-Coated Gold Nanoclusters.
Topics: Chymotrypsin; Gold; Kinetics; Metal Nanoparticles; Thermodynamics; Thioctic Acid | 2020 |
From mono-PEGylation towards anti-nonspecific protein interaction: comparison of dihydrolipoic acid versus glutathione-capped fluorescent gold nanoclusters using gel electrophoresis.
Topics: Electrophoresis; Glutathione; Gold; Metal Nanoparticles; Thioctic Acid | 2020 |
In-vitro activity of lipoic acid against Ureaplasma urealyticum and Ureaplasma parvum isolated from women with infections of the urogenital tract. A pilot study.
Topics: Adult; Anti-Bacterial Agents; Female; Humans; Microbial Sensitivity Tests; Pregnancy; Thioctic Acid; Ureaplasma; Ureaplasma Infections; Ureaplasma urealyticum; Urinary Tract Infections; Urogenital System | 2020 |
Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells.
Topics: Animals; Antioxidants; Caco-2 Cells; Humans; Oxidative Stress; PC12 Cells; Rats; Thioctic Acid | 2021 |
Dihydrolipoic acid enhances autophagy and alleviates neurological deficits after subarachnoid hemorrhage in rats.
Topics: Animals; Antioxidants; Autophagy; Male; Nervous System Diseases; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Thioctic Acid | 2021 |
Dihydrolipoic acid-coated gold nanocluster bioactivity against senescence and inflammation through the mitochondria-mediated JNK/AP-1 pathway.
Topics: Anti-Inflammatory Agents; Cells, Cultured; Cellular Senescence; Coated Materials, Biocompatible; Gold; Humans; Inflammation; MAP Kinase Kinase 4; Metal Nanoparticles; Mitochondria; Thioctic Acid; Transcription Factor AP-1 | 2021 |
Therapy of spinal cord injury by zinc modified gold nanoclusters via immune-suppressing strategies.
Topics: Animals; Cell Survival; Gold; Humans; Lymphocytes; Macrophages; Male; Metal Nanoparticles; Mice; Monocytes; Neuroprotective Agents; Prognosis; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Reactive Oxygen Species; Spinal Cord Injuries; Stereoisomerism; Thioctic Acid; Zinc | 2021 |