Compounds > dihydrokainate
Page last updated: 2024-09-02

dihydrokainate and glutamic acid

dihydrokainate has been researched along with glutamic acid in 106 studies

Compound Research Comparison

Studies
(dihydrokainate)		Trials
(dihydrokainate)		Recent Studies (post-2010)
(dihydrokainate)		Studies
(glutamic acid)		Trials
(glutamic acid)		Recent Studies (post-2010) (glutamic acid)
18004641,75745212,876

Protein Interaction Comparison

ProteinTaxonomydihydrokainate (IC50)glutamic acid (IC50)
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2Rattus norvegicus (Norway rat)0.821
Chain A, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Chain B, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Metabotropic glutamate receptor 8Homo sapiens (human)0.0057
Glutamate receptor ionotropic, NMDA 2DHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BHomo sapiens (human)0.07
Glutamate receptor 1Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 2Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 3Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 4Rattus norvegicus (Norway rat)0.5885
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)0.38
Glutamate receptor 1Homo sapiens (human)0.613
Glutamate receptor 2Homo sapiens (human)0.613
Glutamate receptor 3Homo sapiens (human)0.613
Glutamate receptor ionotropic, kainate 3Rattus norvegicus (Norway rat)0.38
Excitatory amino acid transporter 1Homo sapiens (human)207
Glutamate receptor 4Homo sapiens (human)0.613
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 4Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2CHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 5Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 3AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.1533

Research

Studies (106)

TimeframeStudies, this research(%)All Research%
pre-19905 (4.72)18.7374
1990's32 (30.19)18.2507
2000's45 (42.45)29.6817
2010's23 (21.70)24.3611
2020's1 (0.94)2.80

Authors

AuthorsStudies
Armstrong, N; Gouaux, E1
Bridges, R; Denton, T; Seib, T; Thompson, C1
Aboab, B; Assaf, Z; Bolte, J; Bunch, L; Gefflaut, T; Jensen, AA; Nielsen, B; Pickering, DS; Pu, X; Sagot, E; Stensbøl, TB; Umberti, M1
Bolte, J; Bunch, L; Chapelet, M; Gefflaut, T; Nielsen, B; Pickering, DS; Pu, X; Sagot, E; Stensbøl, TB; Umberti, M1
Amir, A; Brindisi, M; Butini, S; Campiani, G; Coccone, SS; Frydenvang, K; Gemma, S; Guarino, E; Kastrup, JS; Kumar, V; Maramai, S; Novellino, E; Pickering, DS; Valadés, EA; Valenti, S; Venskutonyte, R1
Wayman, CP; Wilson, JF1
Attwell, D; Barbour, B; Brew, H1
Hestrin, S; Nicoll, RA; Sah, P1
Bridges, RJ; Caiozzo, VJ; Gardner, VO; Munden, SK1
Higashima, M; Sawada, S; Yamamoto, C1
Hagberg, H; Hamberger, A; Lazarewicz, JW; Lehmann, A1
Choi, DW; Kriegstein, AR; Maulucci-Gedde, M1
Brodin, L; Grillner, S; Ohta, Y; Tossman, U; Ungerstedt, U1
Hamberger, A; Lehmann, A1
Larsson, HP; Lecar, H; Picaud, S; Wellis, DP; Werblin, F1
Hirota, H; Kano, T; Katayama, Y; Kawamata, T; Tsubokawa, T1
Grunewald, M; Kanner, B1
Davies, JA; Dickie, BG1
Massieu, L; Morales-Villagrán, A; Tapia, R1
Curtis, JT; Sved, AF1
Kondoh, T; Low, WC1
Andersson, K; Chen, Y; Espinoza, S; Godukhin, OV; Goiny, M; Herrera-Marschitz, M; Loidl, CF; Lubec, G; Meana, JJ; Nylander, I; Pettersson, E; Silveira, R; Terenius, L; Ungerstedt, U; You, ZB1
Massieu, L; Tapia, R; Velasco, I1
Fallgren, AB; Paulsen, RE1
Lewin, L; Mattsson, MO; Sellström, A1
Bezzi, P; Meldolesi, J; Rossi, D; Vesce, S; Volterra, A1
Massieu, L; Tapia, R1
Arias, C; Arrieta, I; Massieu, L; Tapia, R1
Gaal, L; Marc, R; Picaud, SA; Roska, B; Werblin, FS; Wu, SM1
Crosson, CE; Ganel, R1
Davis, RE1
Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA1
Aizenman, E; Chung, HJ; Lea, E; Potthoff, WK; Robinson, MB; Rosenberg, PA; Schnuer, J; Wang, GJ1
Gaal, L; Roska, B; Werblin, FS1
Attwell, D; Levy, LM; Warr, O1
Beal McIlvain, H; Dunlop, J; Franco, R; Lou, Z1
Feustel, PJ; Keller, RW; Kimelberg, HK; Seki, Y; Tranmer, BI1
Kanner, BI; Zhang, Y1
Baldwin, RA; Katsumori, H; Wasterlain, CG1
Bridges, RJ; Chamberlin, AR; Koch, HP1
Bacci, A; Coco, S; Fumagalli, G; Matteoli, M; Pravettoni, E; Verderio, C1
Dunlop, J; Lou, Z; McIlvain, HB; Zhang, Y1
Berger, SP; Fox, L; Ho, LB; Reid, MS1
Araque, A; Doyle, RT; Haydon, PG; Li, N1
Trussell, LO; Turecek, R1
Isaac, JT; Kidd, FL2
Kullmann, DM; Semyanov, A1
Diamond, JS; Jahr, CE1
Hughes, MG; McAdoo, DJ; Price, EM; Robak, G; Xu, G1
Dreyer, EB; Gochenauer, G; Mackler, SA; Naskar, R; Quinto, K; Robinson, MB; Schuettauf, F; Vorwerk, CK; Zurakowski, D1
Aoki, M; Berger, UV; Brown, RH; Danbolt, NC; Hediger, MA; Pasinelli, P; Trotti, D1
Bézine, MF; Gaillet, S; Malaval, F; Plachez, C; Récasens, M1
Dawson, LA; Djali, S; Gonzales, C; Vinegra, MA; Zaleska, MM1
Chatton, JY; Magistretti, PJ; Shimamoto, K1
Sadzuka, Y; Sonobe, T; Sugiyama, T; Tanaka, K1
Kimelberg, HK; Zhou, M1
Anderson, CM; Bridges, RJ; Chamberlin, AR; Shimamoto, K; Swanson, RA; Yasuda-Kamatani, Y1
Attwell, D; Hamann, M; Marie, H; Rossi, DJ1
Sadzuka, Y; Sonobe, T; Sugiyama, T; Yamashita, Y1
Jiang, XF; Kamichi, S; Maeno, H; Nagata, I; Namura, S; Takami, S; Wada, K1
Grunewald, M; Kanner, BI; Menaker, D1
Hosoya, R; Iwabuchi, S; Kawahara, K; Nakajima, T; Sato, H; Tanaka, M1
Bergles, DE; Jahr, CE; Tzingounis, AV1
Chen, Y; Swanson, RA1
Barabás, P; Kardos, J; Kovács, I; Schousboe, A1
Thoreson, WB; Tranchina, D; Witkovsky, P1
Fei, J; Guo, LH; Hu, JH; Jiang, J; Ma, YH; Yang, N; Zhang, JF1
Breitner, JC; Cook, DG; Kinney, GA; Spain, WJ; Yang, Y1
Feustel, PJ; Jin, Y; Kimelberg, HK1
Galluzzo, M; Grieco, R; Pèzzola, A; Pintor, A; Popoli, P; Reggio, R1
Arévalo, MA; Brera, B; de Ceballos, ML; Fernández-Tomé, P1
Grebenyuk, S; Kirichok, Y; Krishtal, O; Lozovaya, N; Melnik, S; Tsintsadze, T1
Kettenmann, H; Kresse, W; Rose, C1
Foster, AC; Naeve, GS; Poulsen, DJ; Selkirk, JV; Stiefel, TH; Stone, IM1
Begni, B; Bono, MS; D'Orlando, C; Ferrarese, C; Garofolo, R; Longoni, M; Tremolizzo, L1
Anand, A; Gaskins, D; Lee, Y; Shekhar, A1
Hassel, B; Henjum, S1
Bonanno, G; Fedele, E; Milanese, M; Raiteri, L; Raiteri, M; Zappettini, S1
Chen, JH; Nie, H; Pan, ZZ; Weng, HR1
Fumagalli, E; Funicello, M; Gobbi, M; Mennini, T; Rauen, T1
Hille, B; Kim, MH; Koh, DS; Moriyama, Y; Muroyama, A; Uehara, S1
DeSilva, TM; Goldhoff, PE; Kabakov, AY; Rosenberg, PA; Volpe, JJ1
Kardos, J; Lasztóczi, B; Nyitrai, G1
Bertsche, A; Bruehl, C; Draguhn, A; Pietz, J1
Mishra, V; Raghubir, R; Sasmal, D; Verma, R1
Adams, MA; Bechtholt-Gompf, AJ; Carlezon, WA; Cohen, BM; Ongür, D; Walther, HV1
Guan, X; Lu, W; Petralia, RS; Rothstein, JD; Tao, YX; Yaster, M1
Arnold, JC; Chotibut, T; Davis, RW; Salvatore, MF1
Bechtholt-Gompf, AJ; Carlezon, WA; Cohen, BM; Gompf, HS; John, CS; Öngür, D; Smith, KL; Van't Veer, A1
Owaisat, S; Raffa, RB; Rawls, SM1
Li, J; Lu, XQ; Su, RB; Wu, N; Yan, HT; Zheng, JQ1
Colbert, CM; Eskin, A; Pita-Almenar, JD; Zou, S1
Iwai, T; Kamanaka, G; Kobayashi, K; Oka, J; Sasaki-Hamada, S1
Dulla, C; Freeman, M; Higashimori, H; Huth, J; Lindemann, L; Morel, L; Taylor, A; Yang, Y1
An, C; Su, H; Sun, X; Wang, D; Xu, J; Yan, J; Zhong, J; Zhu, H1
Gong, J; Gong, S; Hu, Y; Li, W; Liu, Y; Zhang, L; Zhang, M1
Barry, SM; Bechtholt, AJ; Cohen, BM; John, CS; Ongür, D; Smith, KL; Sypek, EI1
Hu, YY; Li, L; Li, WB; Wang, D; Xu, J; Zhang, M1
Agostinho, P; Augusto, E; Boison, D; Chen, JF; Cunha, RA; Matos, M; Shen, HY; Wang, Y; Wang, YT; Wei, CJ1
Das, SC; Hristov, AM; Sari, Y; Yamamoto, BK1
Chen, YL; Li, D; Li, RP; Wang, ZZ; Xu, WG; Zhang, JD1
Artigas, F; Castañé, A; Gasull-Camós, J; Tarrés-Gatius, M1
Hasser, EM; Kline, DD; Matott, MP1
Artigas, F; Castañé, A; Gasull-Camós, J; Martínez-Torres, S; Ozaita, A; Tarrés-Gatius, M1
Bian, Q; Gao, Z; Li, Y; Liu, Z; Ma, D; Zhang, S; Zhang, Z1

Other Studies

106 other study(ies) available for dihydrokainate and glutamic acid

ArticleYear
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
    Neuron, 2000, Volume: 28, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Quinoxalines; Receptors, AMPA; Structure-Activity Relationship; Zinc

2000
Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2002, Nov-04, Volume: 12, Issue:21

    Topics: Amino Acid Transport System X-AG; Amino Acid Transport System y+; Carrier Proteins; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamates; Humans; Indicators and Reagents; Membrane Transport Proteins; Models, Molecular; Molecular Conformation; Pyrrolidonecarboxylic Acid; Symporters; Vesicular Glutamate Transport Protein 1; Vesicular Transport Proteins

2002
Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Cell Line; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutarates; Humans; Magnetic Resonance Spectroscopy; Membrane Potentials; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism

2008
Chemo-enzymatic synthesis of a series of 2,4-syn-functionalized (S)-glutamate analogues: new insight into the structure-activity relation of ionotropic glutamate receptor subtypes 5, 6, and 7.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Amination; Animals; Glutamic Acid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Rats; Receptors, Glutamate; Spectrophotometry, Infrared; Structure-Activity Relationship; Synaptosomes

2008
Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.
    Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13

    Topics: Animals; Cell Line; Cricetinae; Crystallography, X-Ray; Female; Ligands; Models, Molecular; Oocytes; Patch-Clamp Techniques; Protein Conformation; Pyrimidines; Rats; Receptors, Kainic Acid; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Xenopus laevis

2011
Endogenous glutamate stimulates release of alpha-melanocyte-stimulating hormone from the rat hypothalamus.
    Neuropeptides, 1992, Volume: 23, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; alpha-MSH; Animals; Glutamates; Glutamic Acid; Hypothalamus; In Vitro Techniques; Kainic Acid; Male; Neurons; Osmolar Concentration; Pro-Opiomelanocortin; Rats; Rats, Wistar

1992
Electrogenic uptake of glutamate and aspartate into glial cells isolated from the salamander (Ambystoma) retina.
    The Journal of physiology, 1991, Volume: 436

    Topics: Ambystoma; Animals; Aspartic Acid; Calcium; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Magnesium; Membrane Potentials; Neuroglia; Potassium; Retina; Sodium

1991
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices.
    Neuron, 1990, Volume: 5, Issue:3

    Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Temperature; Time Factors

1990
Excitotoxins can produce protein degradation in the spinal cord.
    Spine, 1990, Volume: 15, Issue:9

    Topics: Animals; Calcium; Female; Glutamates; Glutamic Acid; Intermediate Filament Proteins; Kainic Acid; N-Methylaspartate; Neurofilament Proteins; Neurotoxins; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spinal Cord

1990
Inhibitors of high-affinity uptake augment depolarizations of hippocampal neurons induced by glutamate, kainate and related compounds.
    Experimental brain research, 1985, Volume: 60, Issue:2

    Topics: Animals; Aspartic Acid; Drug Synergism; Glutamates; Glutamic Acid; Guinea Pigs; Hippocampus; Homocysteine; In Vitro Techniques; Kainic Acid; Oxadiazoles; Quisqualic Acid; Synaptic Transmission

1985
Effects of kainic acid on brain calcium fluxes studied in vivo and in vitro.
    Journal of neurochemistry, 1986, Volume: 46, Issue:2

    Topics: Animals; Astrocytes; Brain; Calcium; Drug Synergism; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Potassium; Rabbits; Synaptosomes; Tetrodotoxin; Veratridine

1986
Glutamate neurotoxicity in cortical cell culture.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:2

    Topics: Animals; Cell Count; Cells, Cultured; Cerebral Cortex; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Histocytochemistry; Immunoenzyme Techniques; Kainic Acid; Membrane Potentials; Mice; Nerve Degeneration

1987
The effect of an uptake inhibitor (dihydrokainate) on endogenous excitatory amino acids in the lamprey spinal cord as revealed by microdialysis.
    Brain research, 1988, Aug-16, Volume: 458, Issue:1

    Topics: Animals; Aspartic Acid; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kainic Acid; Lampreys; Neurotransmitter Agents; Reference Values; Spinal Cord

1988
Dihydrokainic acid affects extracellular taurine and phosphoethanolamine levels in the hippocampus.
    Neuroscience letters, 1983, Jul-15, Volume: 38, Issue:1

    Topics: Animals; Drug Synergism; Ethanolamines; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Potassium; Pyrrolidines; Rabbits; Taurine

1983
Cone photoreceptors respond to their own glutamate release in the tiger salamander.
    Proceedings of the National Academy of Sciences of the United States of America, 1995, Sep-26, Volume: 92, Issue:20

    Topics: Ambystoma; Animals; Aspartic Acid; Calcium; Chloride Channels; Exocytosis; Fluorescent Dyes; Fura-2; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Membrane Potentials; Patch-Clamp Techniques; Picrotoxin; Retinal Cone Photoreceptor Cells; Synapses; Synaptic Transmission; Time Factors

1995
Inhibition of the high-affinity glutamate uptake system facilitates the massive potassium flux during cerebral ischaemia in vivo.
    Neurological research, 1995, Volume: 17, Issue:2

    Topics: Animals; Brain Ischemia; Female; Glutamic Acid; Ion Channel Gating; Kainic Acid; Microdialysis; Potassium; Rats; Rats, Sprague-Dawley

1995
Conformational changes monitored on the glutamate transporter GLT-1 indicate the existence of two neurotransmitter-bound states.
    The Journal of biological chemistry, 1995, Jul-14, Volume: 270, Issue:28

    Topics: Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Glutamic Acid; Kainic Acid; Lithium; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Rats

1995
Modulation of calcium-dependent and -independent components of veratridine-evoked release of glutamate from rat cerebellum.
    Brain research, 1993, Aug-13, Volume: 619, Issue:1-2

    Topics: Amiloride; Animals; Apamin; Aspartic Acid; Calcium; Calcium Channel Blockers; Cerebellum; Cobalt; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Kinetics; omega-Conotoxins; Peptides; Perfusion; Rats; Rats, Wistar; Ruthenium Red; Tetrodotoxin; Verapamil; Veratridine

1993
Accumulation of extracellular glutamate by inhibition of its uptake is not sufficient for inducing neuronal damage: an in vivo microdialysis study.
    Journal of neurochemistry, 1995, Volume: 64, Issue:5

    Topics: Animals; Cell Death; Choline; Choline O-Acetyltransferase; Corpus Striatum; Dicarboxylic Acids; Dizocilpine Maleate; Extracellular Space; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Kainic Acid; Male; Microdialysis; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar

1995
Amino acid neurotransmitters in nucleus tractus solitarius: an in vivo microdialysis study.
    Journal of neurochemistry, 1993, Volume: 61, Issue:6

    Topics: Afferent Pathways; Amino Acids; Animals; Aspartic Acid; Chromatography, High Pressure Liquid; Electric Stimulation; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Male; Membrane Potentials; Microdialysis; Nerve Endings; Neurotransmitter Agents; Nodose Ganglion; Potassium; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Time Factors; Vagus Nerve

1993
Glutamate uptake blockade induces striatal dopamine release in 6-hydroxydopamine rats with intrastriatal grafts: evidence for host modulation of transplanted dopamine neurons.
    Experimental neurology, 1994, Volume: 127, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Male; Mesencephalon; N-Methylaspartate; Neurons; Oxidopamine; Rats; Tyrosine 3-Monooxygenase

1994
On the origin of extracellular glutamate levels monitored in the basal ganglia of the rat by in vivo microdialysis.
    Journal of neurochemistry, 1996, Volume: 66, Issue:4

    Topics: Amino Acids; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Aspartic Acid; Basal Ganglia; Calcium; Cerebral Cortex; Dicarboxylic Acids; Glutamic Acid; Halothane; Kainic Acid; Male; Membrane Potentials; Microdialysis; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Potassium; Presynaptic Terminals; Pyrrolidines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Spider Venoms; Substantia Nigra; Tetrodotoxin; Urethane

1996
Inhibition of glutamate uptake induces progressive accumulation of extracellular glutamate and neuronal damage in rat cortical cultures.
    Journal of neuroscience research, 1996, Jun-15, Volume: 44, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Aspartic Acid; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Kainic Acid; L-Lactate Dehydrogenase; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

1996
A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor.
    Neurochemical research, 1996, Volume: 21, Issue:1

    Topics: Animals; Calcium; Drug Evaluation, Preclinical; Glutamic Acid; Kainic Acid; Male; Membrane Potentials; Microdialysis; Neostriatum; Potassium; Rats; Rats, Wistar; Stimulation, Chemical

1996
Differences in the release of L-glutamate and D-aspartate from primary neuronal chick cultures.
    Neurochemical research, 1996, Volume: 21, Issue:1

    Topics: Animals; Aspartic Acid; Biological Transport; Cells, Cultured; Chick Embryo; Drug Evaluation, Preclinical; Exocytosis; Glutamates; Glutamic Acid; Kainic Acid; Neurons

1996
HIV-1 gp120 glycoprotein affects the astrocyte control of extracellular glutamate by both inhibiting the uptake and stimulating the release of the amino acid.
    FEBS letters, 1997, Jul-07, Volume: 411, Issue:1

    Topics: Animals; Astrocytes; Cells, Cultured; Glutamic Acid; HIV Envelope Protein gp120; Kainic Acid; Rats

1997
Glutamate uptake impairment and neuronal damage in young and aged rats in vivo.
    Journal of neurochemistry, 1997, Volume: 69, Issue:3

    Topics: Aging; Amino Acids; Animals; Aspartic Acid; Corpus Striatum; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Kainic Acid; Kinetics; Male; Microdialysis; Nerve Degeneration; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar

1997
Neuronal damage and MAP2 changes induced by the glutamate transport inhibitor dihydrokainate and by kainate in rat hippocampus in vivo.
    Experimental brain research, 1997, Volume: 116, Issue:3

    Topics: Animals; Biological Transport; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Immunohistochemistry; Kainic Acid; Male; Microtubule-Associated Proteins; Neurons; Quinoxalines; Rats; Rats, Wistar

1997
Postsynaptic response kinetics are controlled by a glutamate transporter at cone photoreceptors.
    Journal of neurophysiology, 1998, Volume: 79, Issue:1

    Topics: Ambystoma; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Calcium; Darkness; Glutamic Acid; Kainic Acid; Kinetics; Light; Magnesium; Membrane Potentials; Patch-Clamp Techniques; Retina; Retinal Cone Photoreceptor Cells; Synapses; Synaptic Transmission

1998
Modulation of human glutamate transporter activity by phorbol ester.
    Journal of neurochemistry, 1998, Volume: 70, Issue:3

    Topics: Amino Acid Transport System X-AG; Anti-Bacterial Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamates; Glutamic Acid; Humans; Kainic Acid; Kinetics; Phorbol Esters; Protein Kinase C; Retinoblastoma; Staurosporine; Tumor Cells, Cultured

1998
Action of excitatory amino acids on hypodermis and the motornervous system of Ascaris suum: pharmacological evidence for a glutamate transporter.
    Parasitology, 1998, Volume: 116 ( Pt 5)

    Topics: Amino Acid Transport System X-AG; Animals; Ascaris suum; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport, Active; Calcium; Dose-Response Relationship, Drug; Electric Conductivity; Epithelium; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Kainic Acid; Membrane Potentials; Microelectrodes; Motor Neurons; Quinoxalines; Sodium

1998
Peroxynitrite causes aspartate release from dissociated rat cerebellar granule neurones.
    Free radical research, 1998, Volume: 28, Issue:2

    Topics: Animals; Aspartic Acid; Brain Ischemia; Calcium; Cerebellar Cortex; Dithiothreitol; Egtazic Acid; Glutamic Acid; Ion Transport; Kainic Acid; Membrane Proteins; Nerve Tissue Proteins; Neurons; Nitrates; Nitric Oxide; Oxidants; Oxidation-Reduction; Rats; Rats, Wistar; Sodium; Sulfhydryl Compounds; Superoxides; Tetrodotoxin

1998
Dihydrokainate-sensitive neuronal glutamate transport is required for protection of rat cortical neurons in culture against synaptically released glutamate.
    The European journal of neuroscience, 1998, Volume: 10, Issue:8

    Topics: Animals; Biological Transport; Calcium; Calcium Radioisotopes; Cell Survival; Cells, Cultured; Cerebral Cortex; Dicarboxylic Acids; Extracellular Space; Fetus; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin

1998
Voltage-dependent uptake is a major determinant of glutamate concentration at the cone synapse: an analytical study.
    Journal of neurophysiology, 1998, Volume: 80, Issue:4

    Topics: Ambystoma; Animals; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Kainic Acid; Light; Magnesium; Models, Neurological; Osmolar Concentration; Reference Values; Retinal Cone Photoreceptor Cells; Synapses

1998
Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1998, Dec-01, Volume: 18, Issue:23

    Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; CHO Cells; COS Cells; Cricetinae; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Potassium; Protons; Sodium

1998
The pharmacological profile of L-glutamate transport in human NT2 neurones is consistent with excitatory amino acid transporter 2.
    European journal of pharmacology, 1998, Nov-06, Volume: 360, Issue:2-3

    Topics: Animals; Biological Transport; Dogs; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Kainic Acid; Neurons; Receptors, Neurotransmitter; Reverse Transcriptase Polymerase Chain Reaction; Stereoisomerism; Tumor Cells, Cultured

1998
Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker.
    Stroke, 1999, Volume: 30, Issue:2

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Blood Flow Velocity; Brain Ischemia; Cerebrovascular Circulation; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Therapy, Combination; Glutamic Acid; Ion Pumps; Kainic Acid; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Stilbenes

1999
Two serine residues of the glutamate transporter GLT-1 are crucial for coupling the fluxes of sodium and the neurotransmitter.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Feb-16, Volume: 96, Issue:4

    Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Aspartic Acid; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport; Glutamic Acid; Glycine; HeLa Cells; Humans; Kainic Acid; Kinetics; Mutagenesis, Site-Directed; Neurotransmitter Agents; Recombinant Proteins; Serine; Sodium

1999
Reverse transport of glutamate during depolarization in immature hippocampal slices.
    Brain research, 1999, Feb-20, Volume: 819, Issue:1-2

    Topics: Aging; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Biological Transport; Calcium; Dicarboxylic Acids; Extracellular Space; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Neurotransmitter Uptake Inhibitors; Potassium; Pyrrolidines; Rats; Rats, Wistar; Sodium

1999
Nontransportable inhibitors attenuate reversal of glutamate uptake in synaptosomes following a metabolic insult.
    Molecular pharmacology, 1999, Volume: 55, Issue:6

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Pyrrolidines; Rats; Synaptosomes; Tritium

1999
Astrocytes are required for the oscillatory activity in cultured hippocampal neurons.
    The European journal of neuroscience, 1999, Volume: 11, Issue:8

    Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette Transporters; Calcium; Cells, Cultured; Dicarboxylic Acids; Glutamic Acid; Hippocampus; Intracellular Membranes; Kainic Acid; Membrane Potentials; Neurons; Oscillometry; Osmolar Concentration; Pyrrolidines; Rats; Synapses

1999
Inducible expression and pharmacology of the human excitatory amino acid transporter 2 subtype of L-glutamate transporter.
    British journal of pharmacology, 1999, Volume: 128, Issue:7

    Topics: Amino Acid Transport System X-AG; Arachidonic Acid; ATP-Binding Cassette Transporters; Cell Line; Cloning, Molecular; DNA, Complementary; Ecdysone; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Kainic Acid; Kinetics; Receptors, Neurotransmitter; Transfection

1999
Nicotine stimulation of extracellular glutamate levels in the nucleus accumbens: neuropharmacological characterization.
    Synapse (New York, N.Y.), 2000, Volume: 35, Issue:2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Denervation; Dicarboxylic Acids; Dopamine; Extracellular Space; Glutamic Acid; Haloperidol; Kainic Acid; Kinetics; Male; Mecamylamine; Microdialysis; Neurotransmitter Uptake Inhibitors; Nicotine; Nucleus Accumbens; Oxidopamine; Pyrrolidines; Rats; Rats, Sprague-Dawley

2000
SNARE protein-dependent glutamate release from astrocytes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Jan-15, Volume: 20, Issue:2

    Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Anti-Bacterial Agents; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Botulinum Toxins; Botulinum Toxins, Type A; Calcium; Cells, Cultured; Coculture Techniques; Dicarboxylic Acids; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Kainic Acid; Macrolides; Membrane Potentials; Membrane Proteins; Nerve Tissue Proteins; Neurons; Proton-Translocating ATPases; Pyrrolidines; Rats; SNARE Proteins; Vesicular Transport Proteins

2000
Control of synaptic depression by glutamate transporters.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Mar-01, Volume: 20, Issue:5

    Topics: Action Potentials; Alanine Transaminase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Anti-Bacterial Agents; Antihypertensive Agents; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Chick Embryo; Cochlear Nucleus; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neural Inhibition; Neuronal Plasticity; Receptors, AMPA; Synaptic Transmission

2000
Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex.
    Neuropharmacology, 2000, Mar-03, Volume: 39, Issue:5

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Benzothiadiazines; Biological Transport; Dicarboxylic Acids; Diuretics; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Neurotransmitter Uptake Inhibitors; Picrotoxin; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium Chloride Symporter Inhibitors; Somatosensory Cortex; Synaptic Transmission; Thalamus

2000
Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors.
    Neuron, 2000, Volume: 25, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Neural Inhibition; Propionates; Quinoxalines; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission

2000
Synaptically released glutamate does not overwhelm transporters on hippocampal astrocytes during high-frequency stimulation.
    Journal of neurophysiology, 2000, Volume: 83, Issue:5

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Drug Synergism; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Patch-Clamp Techniques; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synapses; Synaptic Transmission; Theophylline

2000
Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord.
    Brain research, 2000, May-26, Volume: 865, Issue:2

    Topics: Animals; Glutamic Acid; Kainic Acid; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries

2000
Depression of retinal glutamate transporter function leads to elevated intravitreal glutamate levels and ganglion cell death.
    Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:11

    Topics: Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Blotting, Western; Cell Death; Chromatography, High Pressure Liquid; Dicarboxylic Acids; DNA Primers; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Neurotransmitter Uptake Inhibitors; Oligonucleotides, Antisense; Pyrrolidines; Rats; Rats, Long-Evans; Receptors, Neurotransmitter; Retinal Ganglion Cells; Vitreous Body

2000
Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity.
    The Journal of biological chemistry, 2001, Jan-05, Volume: 276, Issue:1

    Topics: Amino Acid Substitution; Amino Acid Transport System X-AG; Amyotrophic Lateral Sclerosis; Animals; ATP-Binding Cassette Transporters; Biological Transport; Cell Membrane; COS Cells; Cytoplasm; Electric Conductivity; Fluorescent Antibody Technique; Genes, Dominant; Glutamic Acid; Glycosylation; Humans; Kainic Acid; Microinjections; Mutation; Oocytes; RNA, Complementary; Sodium Glutamate; Transfection; Xenopus laevis

2001
Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture.
    Neurochemistry international, 2001, Volume: 38, Issue:4

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cell Differentiation; Cells, Cultured; Culture Media, Serum-Free; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hippocampus; Kainic Acid; Neuroglia; Neurons; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Symporters; Time Factors; Tritium

2001
Characterization of transient focal ischemia-induced increases in extracellular glutamate and aspartate in spontaneously hypertensive rats.
    Brain research bulletin, 2000, Volume: 53, Issue:6

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Brain; Brain Ischemia; Extracellular Space; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Rats; Rats, Inbred SHR; Reperfusion Injury; Tetrodotoxin; Time Factors

2000
Effects of glial glutamate transporter inhibitors on intracellular Na+ in mouse astrocytes.
    Brain research, 2001, Mar-02, Volume: 893, Issue:1-2

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Benzofurans; Binding, Competitive; Cells, Cultured; Dicarboxylic Acids; Dose-Response Relationship, Drug; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; Intracellular Fluid; Kainic Acid; Mice; Neurotransmitter Uptake Inhibitors; Protein Isoforms; Pyrrolidines; Sodium; Stereoisomerism

2001
Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin.
    Toxicology letters, 2001, Apr-30, Volume: 121, Issue:2

    Topics: 2-Aminoadipic Acid; Amino Acid Transport System X-AG; Antineoplastic Agents; ATP-Binding Cassette Transporters; Carbon Radioisotopes; Cell Membrane; Doxorubicin; Drug Synergism; Enzyme Inhibitors; Glutamates; Glutamic Acid; Humans; Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

2001
Kinetics and activation of postsynaptic kainate receptors at thalamocortical synapses: role of glutamate clearance.
    Journal of neurophysiology, 2001, Volume: 86, Issue:3

    Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Central Nervous System Stimulants; Cerebral Cortex; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Kainic Acid; Kinetics; Organ Culture Techniques; Picrotoxin; Rats; Rats, Wistar; Receptors, Kainic Acid; Synapses; Synaptic Transmission; Temperature; Thalamus

2001
Freshly isolated hippocampal CA1 astrocytes comprise two populations differing in glutamate transporter and AMPA receptor expression.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Oct-15, Volume: 21, Issue:20

    Topics: Age Factors; Amino Acid Transport System X-AG; Animals; Astrocytes; ATP-Binding Cassette Transporters; Cell Separation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Ion Channels; Kainic Acid; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA-A

2001
Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal.
    Journal of neurochemistry, 2001, Volume: 79, Issue:6

    Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; ATP-Binding Cassette Transporters; Biological Transport; Carrier Proteins; Cells, Cultured; Dicarboxylic Acids; Glutamic Acid; Kainic Acid; Mice; Nerve Tissue Proteins; Neurons; Prosencephalon; Pyrrolidines; Substrate Specificity

2001
Knocking out the glial glutamate transporter GLT-1 reduces glutamate uptake but does not affect hippocampal glutamate dynamics in early simulated ischaemia.
    The European journal of neuroscience, 2002, Volume: 15, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Hypoxia-Ischemia, Brain; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2002
Effect of dihydrokainate on the antitumor activity of doxorubicin.
    Cancer letters, 2002, May-28, Volume: 179, Issue:2

    Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Drug Synergism; Glutamic Acid; Kainic Acid; Male; Mice; Neoplasms, Experimental; Tumor Cells, Cultured

2002
Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice.
    Neuroscience letters, 2002, May-17, Volume: 324, Issue:2

    Topics: Animals; Brain; Brain Edema; Brain Ischemia; Excitatory Amino Acid Transporter 2; Extracellular Space; Female; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Neurotoxins; Neurotransmitter Uptake Inhibitors; Reperfusion Injury; Water-Electrolyte Balance

2002
Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1.
    The Journal of biological chemistry, 2002, Jul-19, Volume: 277, Issue:29

    Topics: Amino Acid Substitution; Biotin; Cysteine; Excitatory Amino Acid Transporter 2; Glutamic Acid; HeLa Cells; Humans; Indicators and Reagents; Kainic Acid; Models, Molecular; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Secondary; Sodium; Structure-Activity Relationship

2002
Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures.
    Glia, 2002, Volume: 40, Issue:3

    Topics: Animals; Astrocytes; Cell Communication; Cell Death; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Extracellular Space; Fetus; Glutamic Acid; Kainic Acid; Neurons; Neurotoxins; Ouabain; Rats; Receptors, N-Methyl-D-Aspartate

2002
Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Dec-01, Volume: 22, Issue:23

    Topics: Biological Transport; Cell Line; Cesium; Computer Simulation; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Kainic Acid; Kidney; Kinetics; Models, Biological; Patch-Clamp Techniques; Potassium; Sodium; Transfection

2002
The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures.
    Journal of neurochemistry, 2003, Volume: 84, Issue:6

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Binding, Competitive; Biological Transport; Cells, Cultured; Cerebral Cortex; Cysteine; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutathione; Kainic Acid; Mice; Neurons; Sodium; Symporters

2003
Exogenous glutamate and taurine exert differential actions on light-induced release of two endogenous amino acids in isolated rat retina.
    Journal of neuroscience research, 2003, Sep-01, Volume: 73, Issue:5

    Topics: Animals; Dark Adaptation; Dicarboxylic Acids; Glutamic Acid; Kainic Acid; Male; Neurotransmitter Uptake Inhibitors; Organ Culture Techniques; Photic Stimulation; Pyrrolidines; Rats; Rats, Long-Evans; Retina; Taurine

2003
Kinetics of synaptic transfer from rods and cones to horizontal cells in the salamander retina.
    Neuroscience, 2003, Volume: 122, Issue:3

    Topics: Animals; Calcium; Dopamine Antagonists; Dose-Response Relationship, Radiation; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Kinetics; Light; Membrane Potentials; Models, Biological; Neural Conduction; Neurons; Patch-Clamp Techniques; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Spiperone; Synapses; Time Factors; Urodela

2003
Identification of glutamate transporters and receptors in mouse testis.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:3

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Brain; Cells, Cultured; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; GluK2 Kainate Receptor; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Symporters; Synaptosomes; Testis

2004
Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake.
    Journal of neurochemistry, 2004, Volume: 88, Issue:6

    Topics: Amino Acid Transport System X-AG; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biological Transport; Caffeine; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endopeptidases; Enzyme Activators; Enzyme Inhibitors; Excitatory Amino Acid Transporter 3; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Imidazoles; Intracellular Fluid; Kainic Acid; Membrane Proteins; Mice; Mice, Knockout; Neurons; Presenilin-1; Protein Kinase C; Symporters; Thapsigargin

2004
Volume-regulated anion channels are the predominant contributors to release of excitatory amino acids in the ischemic cortical penumbra.
    Stroke, 2004, Volume: 35, Issue:5

    Topics: Amino Acid Transport System X-AG; Animals; Anion Transport Proteins; Aspartic Acid; Astrocytes; Brain Ischemia; Cerebral Cortex; Excitatory Amino Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Kainic Acid; Microdialysis; Neurons; Rats; Receptors, Glutamate; Tamoxifen; Taurine

2004
Adenosine A 2A receptor antagonists prevent the increase in striatal glutamate levels induced by glutamate uptake inhibitors.
    Journal of neurochemistry, 2004, Volume: 89, Issue:1

    Topics: Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Male; Microdialysis; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Pyrimidines; Pyrrolidines; Rats; Rats, Wistar; Receptor, Adenosine A2A; Triazines; Triazoles

2004
Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism.
    Neurobiology of disease, 2004, Volume: 15, Issue:3

    Topics: Amino Acid Transport System X-AG; Amyloid beta-Peptides; Animals; Animals, Newborn; Astrocytes; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Immunohistochemistry; Kainic Acid; Neurons; Peptide Fragments; Peptides; Rats

2004
Protective cap over CA1 synapses: extrasynaptic glutamate does not reach the postsynaptic density.
    Brain research, 2004, Jun-18, Volume: 1011, Issue:2

    Topics: 4-Aminopyridine; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Dizocilpine Maleate; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Models, Neurological; N-Methylaspartate; Neural Inhibition; Neurons; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Synapses

2004
Acute insult of ammonia leads to calcium-dependent glutamate release from cultured astrocytes, an effect of pH.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Adenosine Triphosphate; Amino Acid Transport System X-AG; Ammonia; Animals; Aspartic Acid; Astrocytes; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Egtazic Acid; Endoplasmic Reticulum; Fluoresceins; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Methylamines; Mice; Microscopy, Fluorescence; Spectrometry, Fluorescence; Thapsigargin; Ultraviolet Rays

2005
Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells.
    The European journal of neuroscience, 2005, Volume: 21, Issue:8

    Topics: Amino Acid Transport System X-AG; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Blotting, Western; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Gene Expression; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Humans; Kainic Acid; Mice; Neuroglia; Organ Culture Techniques; Phosphopyruvate Hydratase; Pyramidal Cells; Symporters; Time Factors; Transduction, Genetic; Tritium

2005
Substrate-induced modulation of glutamate uptake in human platelets.
    British journal of pharmacology, 2005, Volume: 145, Issue:6

    Topics: Amino Acid Transport System X-AG; Blood Platelets; Cycloheximide; D-Aspartic Acid; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glycine; Humans; Kainic Acid; Symporters

2005
Glia mechanisms in mood regulation: a novel model of mood disorders.
    Psychopharmacology, 2007, Volume: 191, Issue:1

    Topics: Affect; Amino Acid Transport System X-AG; Amygdala; Animals; Astrocytes; Behavior, Animal; Circadian Rhythm; Dicarboxylic Acids; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Exploratory Behavior; Glutamic Acid; Kainic Acid; Male; Mood Disorders; Neuroglia; Neurotransmitter Uptake Inhibitors; Pyrrolidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Social Behavior

2007
High-affinity glycine and glutamate transport in pig forebrain white and gray matter: a quantitative study.
    Neurochemistry international, 2007, Volume: 50, Issue:5

    Topics: Animals; Biological Transport; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Glutathione; Glycine; Glycine Hydroxymethyltransferase; Glycine Plasma Membrane Transport Proteins; Kainic Acid; Prosencephalon; Sarcosine; Serine; Swine

2007
Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations.
    Journal of neurochemistry, 2007, Volume: 103, Issue:3

    Topics: Animals; Aspartic Acid; Calcium Channels; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Exocytosis; Extracellular Fluid; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hyperkalemia; Kainic Acid; Macrolides; Male; Potassium; Presynaptic Terminals; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Synaptosomes

2007
Glial glutamate transporter 1 regulates the spatial and temporal coding of glutamatergic synaptic transmission in spinal lamina II neurons.
    Neuroscience, 2007, Nov-23, Volume: 149, Issue:4

    Topics: Animals; Benzothiadiazines; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Neurons; Oligopeptides; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission

2007
Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.
    European journal of pharmacology, 2008, Jan-14, Volume: 578, Issue:2-3

    Topics: Amino Acid Transport System X-AG; Animals; Cell Line; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamic Acid; Humans; Kainic Acid; Kinetics; Male; Neuroprotective Agents; Rats; Riluzole; Serine; Synaptosomes; Transfection

2008
Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Oct-22, Volume: 28, Issue:43

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Calcium; Cells, Cultured; Cesium; Chlorides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exocytosis; Glutamic Acid; In Vitro Techniques; Kainic Acid; Macrolides; Magnesium; Male; Melatonin; Membrane Potentials; Pineal Gland; Potassium Chloride; Rats; Rats, Sprague-Dawley

2008
Regulation of glutamate transport in developing rat oligodendrocytes.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jun-17, Volume: 29, Issue:24

    Topics: Animals; Animals, Newborn; Aspartic Acid; Benzodiazepines; Bicuculline; Brain; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Female; Fibroblast Growth Factors; GABA Antagonists; Gangliosides; Gene Expression Regulation, Developmental; Glutamic Acid; Kainic Acid; Membrane Potentials; Neurons; O Antigens; Oligodendroglia; Patch-Clamp Techniques; Platelet-Derived Growth Factor; Pregnancy; Quinoxalines; Rats; Rats, Long-Evans; Sodium Channel Blockers; Tetrodotoxin; Tritium

2009
Glutamate uptake shapes low-[Mg2+] induced epileptiform activity in juvenile rat hippocampal slices.
    Brain research, 2010, Jan-14, Volume: 1309

    Topics: Aging; Animals; Aspartic Acid; CA3 Region, Hippocampal; Dicarboxylic Acids; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epilepsy; Glutamic Acid; Hippocampus; Kainic Acid; Magnesium; Magnesium Deficiency; Male; Neurons; Neurotransmitter Transport Proteins; Organ Culture Techniques; Patch-Clamp Techniques; Pyramidal Cells; Pyrrolidines; Rats; Rats, Wistar; Synaptic Transmission

2010
Region- and pattern-specific effects of glutamate uptake blockers on epileptiform activity in rat brain slices.
    Epilepsy research, 2010, Volume: 88, Issue:2-3

    Topics: 4-Aminopyridine; Animals; Anticonvulsants; Aspartic Acid; Electrophysiology; Entorhinal Cortex; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Kainic Acid; Male; Neurons; Neurotransmitter Uptake Inhibitors; Rats; Rats, Wistar; Synaptic Transmission

2010
Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury.
    European journal of pharmacology, 2010, Jul-25, Volume: 638, Issue:1-3

    Topics: Animals; Brain; Brain Ischemia; Ceftriaxone; Cerebral Infarction; Disease Models, Animal; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Kainic Acid; Male; Neuroglia; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Up-Regulation

2010
Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010, Volume: 35, Issue:10

    Topics: Animals; Astrocytes; Brain; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Kainic Acid; Male; Maze Learning; Memory Disorders; Mood Disorders; Motor Activity; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Self Administration

2010
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
    Anesthesiology, 2011, Volume: 114, Issue:2

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Inflammation; Kainic Acid; Male; Nicotinic Acids; Pain; Phosphoserine; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Spinal Cord

2011
Transient striatal GLT-1 blockade increases EAAC1 expression, glutamate reuptake, and decreases tyrosine hydroxylase phosphorylation at ser(19).
    Experimental neurology, 2012, Volume: 234, Issue:2

    Topics: Animals; Astrocytes; Calcium; Corpus Striatum; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Glutamic Acid; Kainic Acid; Male; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; Synaptosomes; Tyrosine 3-Monooxygenase

2012
Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012, Volume: 37, Issue:11

    Topics: Analysis of Variance; Anhedonia; Animals; Astrocytes; Brain Waves; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Electromyography; Excitatory Amino Acid Agonists; Food Preferences; Glutamic Acid; Kainic Acid; Male; Prefrontal Cortex; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Self Stimulation; Sucrose

2012
In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism.
    Neuroscience letters, 2012, Sep-06, Volume: 525, Issue:1

    Topics: Amphetamines; Animals; Cocaine; Excitatory Amino Acid Antagonists; Glutamic Acid; Harmine; Inhibition, Psychological; Kainic Acid; Nicotine; Nicotinic Antagonists; Planarians; Psychotropic Drugs

2012
Aquaporin-4 deficiency attenuates opioid dependence through suppressing glutamate transporter-1 down-regulation and maintaining glutamate homeostasis.
    CNS neuroscience & therapeutics, 2013, Volume: 19, Issue:1

    Topics: Animals; Aquaporin 4; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Homeostasis; Kainic Acid; Mice; Mice, Knockout; Microdialysis; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Tritium

2013
Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP.
    Learning & memory (Cold Spring Harbor, N.Y.), 2012, Nov-19, Volume: 19, Issue:12

    Topics: Alanine Transaminase; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biophysics; Biotinylation; Cells, Cultured; Colforsin; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Flow Cytometry; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Indoles; Kainic Acid; Long-Term Potentiation; Male; Neurons; Protein Transport; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Valine

2012
Exendin (5-39), an antagonist of GLP-1 receptor, modulates synaptic transmission via glutamate uptake in the dentate gyrus.
    Brain research, 2013, Apr-10, Volume: 1505

    Topics: Analysis of Variance; Animals; Biophysics; Cells, Cultured; Dentate Gyrus; Electric Stimulation; Embryo, Mammalian; Excitatory Amino Acid Agonists; Female; Gene Expression Regulation; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; In Vitro Techniques; Kainic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; Neuroglia; Patch-Clamp Techniques; Peptide Fragments; Pregnancy; Rats; Rats, Wistar; Receptors, Glucagon; RNA, Messenger; Synaptic Transmission

2013
Astroglial FMRP-dependent translational down-regulation of mGluR5 underlies glutamate transporter GLT1 dysregulation in the fragile X mouse.
    Human molecular genetics, 2013, May-15, Volume: 22, Issue:10

    Topics: Animals; Astrocytes; Cerebral Cortex; Down-Regulation; Excitatory Amino Acid Transporter 2; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Knockdown Techniques; Glutamic Acid; Humans; Kainic Acid; Mice; Neurons; Protein Biosynthesis; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2013
Increasing glutamate promotes ischemia-reperfusion-induced ventricular arrhythmias in rats in vivo.
    Pharmacology, 2014, Volume: 93, Issue:1-2

    Topics: Amines; Animals; Arrhythmias, Cardiac; Calcium; Cells, Cultured; Cyclohexanecarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Heart Ventricles; Kainic Acid; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases

2014
Cerebral ischemic preconditioning reduces glutamate excitotoxicity by up-regulating the uptake activity of GLT-1 in rats.
    Amino acids, 2014, Volume: 46, Issue:6

    Topics: Animals; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hippocampus; Ischemic Preconditioning; Kainic Acid; Male; Microdialysis; Rats, Wistar; Up-Regulation

2014
Exploring the role of central astrocytic glutamate uptake in ethanol reward in mice.
    Alcoholism, clinical and experimental research, 2014, Volume: 38, Issue:5

    Topics: Alcohol Drinking; Amino Acid Transport System X-AG; Animals; Astrocytes; Ethanol; Glutamic Acid; Infusions, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Reward

2014
Ceftriaxone modulates uptake activity of glial glutamate transporter-1 against global brain ischemia in rats.
    Journal of neurochemistry, 2015, Volume: 132, Issue:2

    Topics: Animals; Biological Transport; Brain Ischemia; CA1 Region, Hippocampal; Ceftriaxone; Drug Evaluation, Preclinical; Excitatory Amino Acid Transporter 2; Gene Knockdown Techniques; Glutamic Acid; Kainic Acid; Male; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Pyramidal Cells; Random Allocation; Rats; Rats, Wistar; Up-Regulation

2015
Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.
    Biological psychiatry, 2015, Dec-01, Volume: 78, Issue:11

    Topics: Animals; Astrocytes; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Homeostasis; Kainic Acid; Locomotion; Mice; Mice, Inbred C57BL; Mice, Transgenic; Psychomotor Disorders; Pyrimidines; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptosomes; Time Factors; Triazoles

2015
Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats.
    Neuropharmacology, 2015, Volume: 97

    Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Animals; Ceftriaxone; Central Nervous System Depressants; Disease Models, Animal; Ethanol; Excitatory Amino Acid Transporter 2; Extracellular Space; Glutamate-Ammonia Ligase; Glutamic Acid; Kainic Acid; Male; Microdialysis; Nucleus Accumbens; Rats

2015
Glutamate metabolism of astrocytes during hyperbaric oxygen exposure and its effects on central nervous system oxygen toxicity.
    Neuroreport, 2016, Jan-20, Volume: 27, Issue:2

    Topics: Air Pressure; Animals; Astrocytes; Brain; Ceftriaxone; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Kainic Acid; Male; Oxygen; Rats; Rats, Sprague-Dawley

2016
Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats.
    Translational psychiatry, 2017, 02-21, Volume: 7, Issue:2

    Topics: Affect; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Citalopram; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Limbic Lobe; Male; Neuroglia; Prefrontal Cortex; Proto-Oncogene Proteins c-fos; Quinoxalines; Raphe Nuclei; Rats; Selective Serotonin Reuptake Inhibitors; Serotonin; Veratridine

2017
Glial EAAT2 regulation of extracellular nTS glutamate critically controls neuronal activity and cardiorespiratory reflexes.
    The Journal of physiology, 2017, 09-01, Volume: 595, Issue:17

    Topics: Action Potentials; Animals; Excitatory Amino Acid Transporter 2; Glutamic Acid; Kainic Acid; Male; Neuroglia; Neurons; Rats, Sprague-Dawley; Receptors, AMPA; Reflex; Respiration; Solitary Nucleus

2017
Serotonergic mechanisms involved in antidepressant-like responses evoked by GLT-1 blockade in rat infralimbic cortex.
    Neuropharmacology, 2018, 09-01, Volume: 139

    Topics: Animals; Antidepressive Agents; Cerebral Cortex; Citalopram; Depressive Disorder; Dorsal Raphe Nucleus; GABAergic Neurons; Glucose Transporter Type 1; Glutamic Acid; Kainic Acid; Male; Motor Activity; Piperazines; Proto-Oncogene Proteins c-fos; Pyridines; Random Allocation; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonergic Neurons; Serotonin; Serotonin Agents; Synaptic Transmission

2018
Mild hypothermia protects rat cortical neurons against oxygen-glucose deprivation/reoxygenation injury via the PI3K/Akt pathway.
    Neuroreport, 2021, 03-03, Volume: 32, Issue:4

    Topics: Animals; Cell Survival; Cerebral Cortex; Chromones; Excitatory Amino Acid Transporter 2; Glutamic Acid; Hypothermia, Induced; In Vitro Techniques; Ischemic Stroke; Kainic Acid; Morpholines; Neurons; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Reperfusion Injury

2021