Page last updated: 2024-09-03

dihydroethidium and allopurinol

dihydroethidium has been researched along with allopurinol in 16 studies

Compound Research Comparison

Studies
(dihydroethidium)
Trials
(dihydroethidium)
Recent Studies (post-2010)
(dihydroethidium)
Studies
(allopurinol)
Trials
(allopurinol)
Recent Studies (post-2010) (allopurinol)
30839915,0967433,363

Protein Interaction Comparison

ProteinTaxonomydihydroethidium (IC50)allopurinol (IC50)
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase Rattus norvegicus (Norway rat)3.3765
Xanthine dehydrogenase/oxidaseHomo sapiens (human)3.1861
Xanthine dehydrogenase/oxidaseBos taurus (cattle)5.0758
Histamine H3 receptorCavia porcellus (domestic guinea pig)8.69

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (12.50)18.2507
2000's9 (56.25)29.6817
2010's5 (31.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carter, WO; Narayanan, PK; Robinson, JP1
Budd, SL; Castilho, RF; Nicholls, DG1
Ali, MH; Gewertz, BL; Hynes, KL; Mungai, PT; Pearlstein, DP; Schumacker, PT1
Faraci, FM; Gunnett, CA; Heistad, DD1
Joseph, J; Kalivendi, S; Kalyanaraman, B; Nithipatikom, K; Vásquez-Vivar, J; Zhang, H; Zhao, H1
Ball, BA; Burnaugh, L; Sabeur, K1
Dusting, GJ; Peshavariya, HM; Selemidis, S1
Bao, HF; Eaton, DC; Helms, MN; Self, JL; Yu, L1
Baudry, N; Laemmel, E; Vicaut, E1
Assimakopoulos, SF; Georgiou, CD; Gogos, C; Grintzalis, K; Papapostolou, I; Thomopoulos, KC; Vagianos, CE1
Fan, E; Huang, D; Ji, H; Kondo, M; Kou, Y; Ou, B; Zhang, L1
Chen, CC; Hsu, YJ; Lee, TM1
Curi, R; Hirabara, SM; Lambertucci, RH; Pithon-Curi, TC; Silveira, Ldos R; Sweeney, G1
Aliaga, ME; Bohle, P; Faúndez, M; Letelier, ME; Lissi, E; López-Alarcón, C; Reyes, C; Rojas, M; Speisky, H1
Chen, J; Kavdia, M; Rogers, SC1
Bikineyeva, A; Dikalov, SI; Nazarewicz, RR1

Other Studies

16 other study(ies) available for dihydroethidium and allopurinol

ArticleYear
Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells.
    Journal of leukocyte biology, 1994, Volume: 55, Issue:2

    Topics: Allopurinol; Animals; Cell Adhesion; Cell Communication; Cell-Free System; Cells, Cultured; Endothelium, Vascular; Ethidium; Fluoresceins; Fluorescent Dyes; Hydrogen Peroxide; Kinetics; Neutrophils; Phenanthridines; Pulmonary Artery; Rats; Spectrometry, Fluorescence; Superoxide Dismutase; Superoxides; Time Factors

1994
Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells.
    FEBS letters, 1997, Sep-22, Volume: 415, Issue:1

    Topics: Animals; Antimycin A; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cerebellum; Ethidium; Fluorescent Dyes; Hydrogen Peroxide; Membrane Potentials; Microscopy, Fluorescence; Mitochondria; Oligomycins; Oxidation-Reduction; Phenanthridines; Rats; Rats, Wistar; Rotenone; Superoxide Dismutase; Superoxides; Xanthine; Xanthine Oxidase

1997
Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia.
    Arteriosclerosis, thrombosis, and vascular biology, 2002, Apr-01, Volume: 22, Issue:4

    Topics: Acetophenones; Allopurinol; Analysis of Variance; Antioxidants; Capillary Permeability; Cell Hypoxia; Cells, Cultured; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Ethidium; Fluoresceins; Fluorescent Dyes; Humans; Interleukin-6; Mitochondria; NF-kappa B; Onium Compounds; Oxidation-Reduction; Reactive Oxygen Species; RNA, Messenger; Rotenone; Umbilical Veins

2002
Interleukin-10 protects nitric oxide-dependent relaxation during diabetes: role of superoxide.
    Diabetes, 2002, Volume: 51, Issue:6

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Allopurinol; Animals; Arteries; Blood Glucose; Citric Acid; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Female; Fluorescent Dyes; Interleukin-10; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Phenanthridines; Polyethylene Glycols; Superoxide Dismutase; Superoxides; Vasoconstrictor Agents; Xanthine Oxidase

2002
Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: potential implications in intracellular fluorescence detection of superoxide.
    Free radical biology & medicine, 2003, Jun-01, Volume: 34, Issue:11

    Topics: Chromatography, High Pressure Liquid; DNA; Ethidium; Fluorescence; Fluorescent Dyes; Hydrazines; Mass Spectrometry; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrogen Oxides; Oxidation-Reduction; Phenanthridines; Superoxide Dismutase; Superoxides; Xanthine; Xanthine Oxidase

2003
Generation of superoxide anion by equine spermatozoa as detected by dihydroethidium.
    Theriogenology, 2007, Volume: 67, Issue:3

    Topics: Animals; Calcimycin; Clinical Laboratory Techniques; Ethidium; Flow Cytometry; Fluorescence; Horses; Ionophores; Male; NADP; Spermatozoa; Superoxides; Xanthine Oxidase

2007
Analysis of dihydroethidium fluorescence for the detection of intracellular and extracellular superoxide produced by NADPH oxidase.
    Free radical research, 2007, Volume: 41, Issue:6

    Topics: Acridines; Cells, Cultured; Endothelium, Vascular; Ethidium; Fluorescence; HL-60 Cells; Humans; Luminescence; Luminescent Agents; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; RNA, Small Interfering; Superoxide Dismutase; Superoxides; Xanthine; Xanthine Oxidase

2007
Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:5

    Topics: Aldosterone; Animals; Antioxidants; Cell Line; Cyclic GMP; Cyclic N-Oxides; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Ethidium; Fluorescent Dyes; Hypoxanthine; Nephrons; Nitric Oxide; Reactive Nitrogen Species; Superoxide Dismutase; Superoxides; Xanthine Oxidase; Xenopus laevis

2007
In vivo reactive oxygen species production induced by ischemia in muscle arterioles of mice: involvement of xanthine oxidase and mitochondria.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:2

    Topics: Animals; Arterioles; Blood Pressure; Ethidium; Fluorescent Dyes; Ischemia; Mice; Mice, Inbred BALB C; Microcirculation; Mitochondria, Muscle; Muscle, Skeletal; Reactive Oxygen Species; Regional Blood Flow; Reperfusion Injury; Superoxide Dismutase; Xanthine Oxidase

2008
Plasma superoxide radical in jaundiced patients and role of xanthine oxidase.
    The American journal of the medical sciences, 2008, Volume: 336, Issue:3

    Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Allopurinol; Bilirubin; Female; Free Radical Scavengers; gamma-Glutamyltransferase; Humans; Jaundice, Obstructive; Lipid Peroxidation; Male; Middle Aged; Phenanthridines; Plasma; Superoxides; Thiobarbituric Acid Reactive Substances; Xanthine Oxidase

2008
Novel high-throughput assay for antioxidant capacity against superoxide anion.
    Journal of agricultural and food chemistry, 2009, Apr-08, Volume: 57, Issue:7

    Topics: Antioxidants; Fluorescent Dyes; Fruit; Oxidation-Reduction; Phenanthridines; Phenols; Plant Extracts; Sensitivity and Specificity; Superoxide Dismutase; Superoxides; Xanthine; Xanthine Oxidase

2009
Differential effects of NADPH oxidase and xanthine oxidase inhibition on sympathetic reinnervation in postinfarct rat hearts.
    Free radical biology & medicine, 2011, Jun-01, Volume: 50, Issue:11

    Topics: Acetophenones; Allopurinol; Animals; Arrhythmias, Cardiac; Coronary Vessels; Ethidium; Male; Molsidomine; Myocardial Infarction; Myocardium; NADPH Oxidases; Nerve Growth Factor; Oxidative Stress; Peroxynitrous Acid; Rats; Rats, Wistar; Superoxides; Sympathetic Nervous System; Tyrosine; Xanthine Oxidase

2011
Effects of moderate electrical stimulation on reactive species production by primary rat skeletal muscle cells: cross talk between superoxide and nitric oxide production.
    Journal of cellular physiology, 2012, Volume: 227, Issue:6

    Topics: Animals; Cells, Cultured; Cytochromes c; Electric Stimulation; Enzyme Inhibitors; Ethidium; Fluorescein; Free Radical Scavengers; Mitochondria, Muscle; Muscle Contraction; Muscle Fibers, Skeletal; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Oxidative Stress; Primary Cell Culture; Rats; Rats, Wistar; Signal Transduction; Superoxides; Time Factors; Xanthine; Xanthine Oxidase

2012
Pyrogallol red oxidation induced by superoxide radicals: application to evaluate redox cycling of nitro compounds.
    Analytical biochemistry, 2011, Dec-15, Volume: 419, Issue:2

    Topics: Animals; Cytochromes c; Ethidium; Hydrogen Peroxide; Male; Microsomes, Liver; Nitro Compounds; Oxidation-Reduction; Pyrogallol; Rats; Rats, Sprague-Dawley; Superoxides; Xanthine; Xanthine Oxidase

2011
Analysis of kinetics of dihydroethidium fluorescence with superoxide using xanthine oxidase and hypoxanthine assay.
    Annals of biomedical engineering, 2013, Volume: 41, Issue:2

    Topics: Ethidium; Fluorescence; Fluorescent Dyes; Hypoxanthine; Kinetics; Superoxides; Xanthine Oxidase

2013
Rapid and specific measurements of superoxide using fluorescence spectroscopy.
    Journal of biomolecular screening, 2013, Volume: 18, Issue:4

    Topics: Cells, Cultured; Endothelial Cells; Ethidium; Humans; Spectrometry, Fluorescence; Superoxides; Xanthine Oxidase

2013