dihydroergotoxine has been researched along with 4-hydroxyestradiol* in 1 studies
1 other study(ies) available for dihydroergotoxine and 4-hydroxyestradiol
| Article | Year |
|---|---|
Do catecholestrogens interact with the in vitro binding of radioligands to catecholamine receptors?
Using a competitive binding assay the effects of 2-hydroxyestradiol-17 beta, 4-hydroxyestradiol-17 beta, estradiol-17 beta and progesterone on the binding of tritiated catecholaminergic ligands to membrane preparations from rat brain and pituitary gland were studied. Up to a concentration of 10(-5) M none of the steroids tested was able to displace [3H]spiroperidol, [3H]dihydroergocryptine or [3H]dihydroalprenolol. The data suggest that the catecholestrogens do not interfere directly with the binding of catecholaminergic ligands to dopaminergic, alpha-adrenergic or beta-adrenergic receptors in the central nervous system. The view that a catechol structure is not essential for the interaction with dopaminergic receptors was further supported by the results obtained from additional studies on the competition of O-methylated and deaminated dopamine metabolites with [3H]spiroperidol binding. Topics: Animals; Binding, Competitive; Brain; Dihydroalprenolol; Dihydroergotoxine; Estradiol; Estrogens, Catechol; Female; Humans; In Vitro Techniques; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Catecholamine; Spiperone; Structure-Activity Relationship | 1983 |