dihydroeponemycin has been researched along with eponemycin* in 1 studies
1 other study(ies) available for dihydroeponemycin and eponemycin
| Article | Year |
|---|---|
Eponemycin analogues: syntheses and use as probes of angiogenesis.
Derivatives of the epoxy-beta-aminoketone containing natural product eponemycin have been prepared in order to study the molecular mode of action of this anti-angiogenic compound. Synthesis and use of a biotinylated dihydroeponemycin analogue demonstrated that dihydroeponemycin forms a covalent adduct with at least two intracellular proteins in human endothelial cells. Pretreatment of cells with a five equivalent excess of dihydroeponemycin precluded biotin-dihydroeponemycin binding indicating a specific interaction between natural product and the target proteins. This biotin-dihydroeponemycin derivative will prove useful in the purification and identification of eponemycin receptors. Topics: Amides; Animals; Antibiotics, Antineoplastic; Biotin; Cattle; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Humans; Ligands; Neovascularization, Physiologic; Receptors, Drug; Serine | 1998 |