dihydroartemisinin has been researched along with artemisinin* in 2 studies
2 other study(ies) available for dihydroartemisinin and artemisinin
| Article | Year |
|---|---|
In vitro efficacy of synthesized artemisinin derivatives against Leishmania promastigotes.
Leishmaniasis is a neglected tropical disease affecting thousands worldwide, especially in developing countries where it co-exists with malaria. Only a handful of drugs are clinically available to treat the disease, but significant limitations threaten their very use. New, safe and effective drugs, including those against malaria-leishmaniasis co-infections, are thus imperative. We assessed the in vitro anti-infective potential of previously synthesized, potent antimalarial artemisinin derivatives. Analogue esters featuring 1,1'-biphenyl and thiophenyl moieties were as much as 30-fold more potent than clinical artemisinins against L. donovani parasites, qualifying them as antipromastigote hits for further investigation in the search for malaria-leishmaniasis co-infection therapies. Topics: Antimalarials; Artemisinins; Dose-Response Relationship, Drug; Leishmania; Molecular Structure; Parasitic Sensitivity Tests; Structure-Activity Relationship | 2020 |
Synthesis and biological activities of artemisinin-piperazine-dithiocarbamate derivatives.
Twelve derivatives of artemisinin-piperazine-dithiocarbamate have been synthesised, and some of them showing good in vitro cytotoxic activity. Compound 3g exhibits the best inhibitory activity against SMMC-7721 cell lines with an IC Topics: Antineoplastic Agents; Apoptosis; Artemisinins; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Piperazine; Structure-Activity Relationship; Thiocarbamates; Tumor Cells, Cultured | 2019 |