dihydroagarofuran has been researched along with celastrol* in 1 studies
1 other study(ies) available for dihydroagarofuran and celastrol
| Article | Year |
|---|---|
Dihydro-β-agarofurans from the roots of the Australian endemic rainforest tree Maytenus bilocularis act as leucine transport inhibitors.
Phytochemical studies of the roots of the Australian plant, Maytenus bilocularis, resulted in the identification of six previously undescribed dihydro-β-agarofuran sesquiterpenoids, bilocularins D-I, along with three known natural products, namely 1α,2α,6β,15-tetraacetoxy-9β-benzoyloxydihydro-β-agarofuran, pristimerin, and celastrol. The structures of all compounds were characterized via analysis of 1D/2D NMR and MS data. The absolute configuration of bilocularin D was defined by X-ray crystallography analysis. Bilocularins D and G, 1α,2α,6β,15-tetraacetoxy-9β-benzoyloxydihydro-β-agarofuran, and celastrol inhibited leucine transport in the human prostate cancer cell line LNCaP with IC Topics: Australia; Celastraceae; Crystallography, X-Ray; Humans; Leucine; Maytenus; Molecular Structure; Pentacyclic Triterpenes; Plant Roots; Rainforest; Sesquiterpenes; Trees; Triterpenes | 2018 |