digoxin has been researched along with periplocin* in 1 studies
1 other study(ies) available for digoxin and periplocin
| Article | Year |
|---|---|
Determination and pharmacokinetics of periplocin in rat plasma by LC-MS.
A simple and sensitive LC-MS method for the determination of periplocin in rat plasma was developed and validated. The chromatographic separation was carried out using a reverse-phase Kromasil C(18) column(150 × 4.6 mm, i.d., 5 µm) with a mobile phase composed of methanol-water (76:24, v/v). The flow rate of mobile phase was 0.8 mL/min. The calibration curve was linear within the concentration range 1-1000 ng/mL. The intra- and inter-day precisions across three validation days over the entire concentration range was lower than 9.2% in terms of relative standard deviation. Accuracy determined at three quality control concentrations ranged from -2.0 to 6.0% in terms of relative error. The validated method was applied to the pharmacokinetic study of periplocin in rat plasma after intravenous and intramuscular administration. Topics: Analysis of Variance; Animals; Area Under Curve; Chromatography, Liquid; Digoxin; Drug Stability; Linear Models; Male; Methanol; Rats; Rats, Wistar; Reproducibility of Results; Saponins; Spectrometry, Mass, Electrospray Ionization | 2010 |