digoxin and neriifolin

digoxin has been researched along with neriifolin* in 1 studies

Other Studies

1 other study(ies) available for digoxin and neriifolin

ArticleYear
[Inhibitory action of peruvoside and neriifolin on Na+, K(+)-ATPase].
    Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:6

    Effects of peruvoside and neriifolin, main components of neriperside, a tevetoside extracted from Thevitia neriifolia Juss, on Na+, K(+)-ATPase activities and on [3H] ouabain binding to the Na+, K(+)-ATPase isolated from hearts of guinea pigs, dogs and cats and kidneys of guinea pigs and cats were compared with digoxin and ouabain. It was found that peruvoside and neriifolin inhibited Na+, K(+)-ATPase activities and they showed a strong competitive inhibition on [3H] ouabain binding to the enzymes isolated from various tissues. A marked species difference existed as great as that of digitalis. The mechanism of action of these 2 drugs may be similar to that of digitalis. Their inhibitory effects on the enzyme activity were stronger than their positive inotropic effects, while both actions of digitalis were parallel quantitatively. There may be some differences in the modulation of the intracellular Ca2+ between neripersides and digitalis.

    Topics: Animals; Binding, Competitive; Cardenolides; Cardiotonic Agents; Cats; Digoxin; Dogs; Guinea Pigs; Kidney; Myocardium; Ouabain; Sodium-Potassium-Exchanging ATPase; Species Specificity

1990